08-03-2012 дата публикации
Номер: US20120058989A1
Автор:
Aggen James B.,
Belliotti Thomas R.,
Gaston Ricky D.,
Goldblum Adam A.,
Griffin John H.,
Harris Christina R.,
Linsell Martin S.,
McEnroe Glenn A.,
Melnick Michael J.,
Moser Heinz E.,
Poel Toni-Jo,
Simons Lloyd J.,
Wagman Allan S.
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): 2. A compound of wherein A-B-D claim 1 , taken together claim 1 , are —CHCHCH— claim 1 , —CH(CH)CHCH— claim 1 , —C(CH)CHCH— claim 1 , —CHCH═CH— claim 1 , —CH═CHCH— claim 1 , CH(OR)CHCH— claim 1 , —C(CH)(OR)CHCH— claim 1 , —CH(N(R))CHCH— claim 1 , —C(CH)(N(R))CHCH— claim 1 , —C(═NOR)CHCH— claim 1 , —C(═O)N(R)CH— claim 1 , —CHCH(OR)CH— claim 1 , —CHC(CH)(OR)CH— claim 1 , —CHCH(N(R))CH— claim 1 , —CHC(═NOR)CH— claim 1 , —CHC(═O)CH— claim 1 , —CHC(CH)CH— claim 1 , —CHOCH— claim 1 , —CHSCH— claim 1 , —CHS(═O)CH— claim 1 , —CHSOCH— claim 1 , —CHN(R)CH— claim 1 , —CHCHCH(CH)— claim 1 , —CHCHC(CH)— claim 1 , —CHC(═O)N(R)— claim 1 , —CHN(R)C(═O)— claim 1 , —CHSON(R)— claim 1 , —CHN(R)SO— claim 1 , —CHCHO— claim 1 , —CHCHN(R)— claim 1 , —CHCHS(═O)— or —CHCHSO—.3. A compound of wherein A-B-D claim 1 , taken together claim 1 , are —C(R)C(R)C(R)— claim 1 , —C(R)C(R)═C(R)— or —C(R)═C(R)C(R)—.46-. (canceled)7. A compound of wherein each Ris hydrogen.8. A compound of wherein A is —CH—.9. A compound of wherein B-D claim 8 , taken together claim 8 , are —C(R)O— claim 8 , —OC(R)— claim 8 , —C(R)S— claim 8 , —SC(R)— claim 8 , —C(R)N(R)— claim 8 , —N(R)C(R)— claim 8 , —C(R)C(R)— claim 8 , —C(R)═C(R)— or —N═C(R)—.1013-. (canceled)14. A compound of wherein B is —O—.1532-. (canceled)33. A compound of wherein R claim 1 , R claim 1 , Rand Rare claim 1 , independently claim 1 , hydrogen claim 1 , amino claim 1 , optionally substituted alkyl claim 1 , optionally substituted cycloalkyl claim 1 , optionally substituted alkylamino or —N(R).34. (canceled)35. A compound of wherein R claim 33 , Rand Rare each hydrogen and Ris amino claim 33 , substituted alkyl claim 33 , substituted cycloalkyl claim 33 , alkylamino claim 33 , or —N(R) claim 33 , wherein substituted alkyl is —(C-Calkyl)N(R)and substituted cycloalkyl is —(C-Ccycloalkyl)N(R).36. (canceled)37. A compound of wherein Ris —NH claim 35 , — ...
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