HOCHTEMPERATUR KRYOGENE KONSERVIERUNG VON BIOLOGISCH AKTIVEM MATERIAL

T-Cell Stimulating Protein B and Methods of Use

Polypeptides that can elicit antibodies that bind to T-cell stimulating protein B (TspB) of N. meningitidis , and methods of use, are provided.

Gasket with positioning feature for clamped monolithic showerhead electrode

An electrode assembly for a plasma reaction chamber used in semiconductor substrate processing. The assembly includes an upper showerhead electrode which is mechanically attached to a backing plate by a series of spaced apart cam locks. A thermally and electrically conductive gasket with projections thereon is compressed between the showerhead electrode and the backing plate at a location three to four inches from the center of the showerhead electrode. A guard ring surrounds the backing plate and is movable to positions at which openings in the guard ring align with openings in the backing plate so that the cam locks can be rotated with a tool to release locking pins extending from the upper face of the electrode.

Inter-axle differential assembly

An inter-axle differential (IAD) assembly including a unitary IAD case having one or more spaced-apart apertures extending therethrough, wherein each of the IAD case apertures defines a groove, and a spider having a plurality of radially, outwardly extending legs, wherein one or more of the legs include an opening at an outward end thereof, and wherein each IAD case apertures are aligned with each of the leg openings. The IAD assembly further includes a locking mechanism having one or more fastening elements, wherein the fastening elements are selectively inserted through the IAD case apertures and into the one or more leg openings and/or into the grooves of the IAD case apertures.

Effluent processing apparatus and method for a vehicle air brake charging system

An effluent processing apparatus is provided for a vehicle air brake charging system. The effluent processing apparatus comprises an inlet port through which effluent from a purge valve of an air dryer can be received and an outlet port. The effluent processing apparatus also comprises a spiral-shaped effluent channel having a portion of decreasing channel width disposed between the inlet port and the outlet port. The spiral-shaped effluent channel is provided for increasing velocity of an effluent stream as the effluent stream flows through the decreasing channel width portion of the spiral-shaped effluent channel.

Energy conservation in heavy-hydrocarbon distillation

An aromatics complex producing one or more xylene isomers offers a large number of opportunities to conserve energy by heat exchange within the complex. One previously unrecognized opportunity is through providing two parallel distillation columns operating at different pressures to separate C 8 aromatics from C 9 + aromatics. The parallel columns offer additional opportunities to conserve energy within the complex through heat exchange in associated xylene recovery facilities.

Effluent Processing Apparatus and Method for a Vehicle Air Brake Charging System

An effluent processing apparatus comprises a coalescing element arranged to separate oil and water from an effluent mixture containing air, oil, and water from a purge valve of an air dryer. The coalescing element includes a plurality of members which define a predefined pattern of paths along which the effluent mixture flows to separate oil and water therefrom.

Tip resistant optical testing instrument

Apparatuses and associated methods of manufacturing are described that provide a tip resistant optical testing instrument configured to rest on a surface. The optical testing instrument includes a shell defining a cavity for receiving a sample tube. The shell includes a bottom shell surface, wherein the bottom shell surface defines at least one support element, wherein the at least one support element is configured to engage the surface to support the optical testing instrument in a testing position, and a translational surface configured to engage the surface to support the optical testing instrument in an angled position. In an instance in which the optical testing instrument tilts from the testing position to the angled position, the translational surface is configured to engage the surface contacting the translational surface to prevent the optical testing instrument from tipping further and allow the optical testing instrument to return to the testing position.

Optical test platform

Provided herein are an optical test platform and corresponding method of manufacturing the same. The test platform may include a shell defining a cavity for receiving a sample tube, a first aperture, and a second aperture. The first aperture and the second aperture of the shell may each be configured to optically couple the cavity with an exterior of the shell. The test platform may further include a first window and a second window embedded in the shell. The first window may seal a first aperture and the second window may seal a second aperture. The first window and second window may each permit the optical coupling of the cavity with the exterior of the shell. The first window and the second window may be optically coupled via the cavity, and the shell may prohibit optical coupling between the first window and the second window through the shell.

Ligation clip with latching and retention features

A surgical ligation clip includes a first jaw, a second jaw, and a hinge portion that pivotably couples the first jaw to the second jaw. The first and second jaws define respective clamping surfaces and include spaced bosses. Each of the spaced bosses include a transverse portion and a head portion that is oversized and has a diameter that is larger than the diameter of the transverse portions. The oversized head portions allow for the ligation clips to be securely supported on a clip applicator.

Derivatives of piperlongumine and uses thereof

The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition and formulation containing a derivative of piperlongumine; and use of the derivatives and analogs for treating cancer, reducing inflammation and/or treating an autoimmune or inflammatory disease.

Therapeutic stimulatory massage device

A therapeutic stimulatory massage device for receipt therein of a body portion, such device containing a thixotropic fluid medium (16) subject to selective increase in viscosity and increase in pressure at such areas of increased viscosity. Also, other therapeutic modes can be incorporated into the device of this invention.

Therapeutic stimulatory massage device

A therapeutic stimulatory massage device for receipt therein of a body portion, such device containing a thixotropic fluid medium subject to selective increase in viscosity and increase in pressure at such areas of increased viscosity. Also, other therapeutic modes can be incorporated into the device of this invention.

Method and apparatus for tuning a communication device for multiband operation

In one example, a wireless communication device adapted for multi-band operation includes a first antenna, a first diplexer configured to pass signals within first and second sets of frequency bands, first and second signal paths, wherein each signal path includes a set of notch filters tunable to attenuate a different frequency. The wireless communication device includes a second antenna, a second diplexer configured to pass the first and second frequency bands, third and fourth signal paths, wherein each of the third and fourth signal paths includes one or more notch filters tunable to attenuate a different frequency, and a transceiver coupled to each signal path.

Methods and apparatus for emphasizing frequency blocks containing priority data

PROMOTER MOLECULES FOR USE IN PLANTS

Wallboard joint compound

The present invention is an improved wallboard joint compound comprising an inorganic joint compound such as, for example, gypsum, mixed with water, plus one or more additives selected to reduce the moisture in the gypsum compound and improve the strength of the finished wallboard joint. The first additive is selected from a class of water soluble functional polymer with either nitrogen or sulfonate, such as, for example, polyvinyl pyrrolidone (PVP). A second additive is selected from a class of solid epoxy resins, preferably added together with the first additive. These two additives, when mixed with the joint compound alone or in combination, produced a more flexible, higher strength wallboard with a reduce moisture content and quicker drying time.

Polyester composition

Isotropic polyester compositions containing specified amounts of certain reinforcing fillers, a polymeric toughening agent, and a liquid crystalline polymer are especially useful for parts which have appearance surfaces and/or are painted. Such compositions are useful for items such as appliance parts, automotive body panels, power tool housing, and electronics housings. Processes for coating such compositions are also described.

Membrane compositions and methods for making and using them

Non-specific dna amplification

A method of non-specifically amplifying different-sequence fragments in a mixture of duplex DNA fragments is disclosed. The fragments are provided with end linkers, and the mixture is amplified by successive primer-initiated replication. Also disclosed is a method of cloning cDNA species which are homologous to a region of contiguous genomic DNA and are selected from a mixture of cDNA species.

Nucleotide and nucleoside compositions and uses related thereto

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

N4-hydroxycytidine and derivatives and anti-viral uses related thereto

This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds.

Nucleotide and nucleoside compositions and their uses

Knotless suture anchors

【課題】骨に組織を付着させるための改善された装置、システム、及び方法を提供すること。【解決手段】組織を骨に固定するための方法及びシステムが提供される。縫合糸アンカーシステムは、カニューレ状縫合糸アンカーであって、内腔内に配置された被駆動特徴部と、外面上に配置された少なくとも１つの骨係合特徴部とを有する、カニューレ状縫合糸アンカーを含むことができる。カニューレ状挿入部材は、内腔を備えた細長い部材を有することができ、アンカーの内腔内に配置することができる。細長い部材は、被駆動特徴部と係合することができる駆動特徴部を有することができる。内管は、挿入部材の内腔内に配置することができる。内管は、内管がアンカーを越えて遠位に延びるように、アンカーよりも大きい内腔及び長さを有することができる。遠位スイベル部材は、内腔と、縫合糸分離特徴部を有する遠位端とを有することができる。遠位スイベル部材は、アンカーに隣接して取り付けることができ、アンカーに対して回転可能であり得る。【選択図】図１

Invertebrate micrornas

Phosphoramidates for the treatment of hepatitis b virus

Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.

Phosphoramidates for the treatment of hepatitis B virus

Disclosed are compounds and compositions to the treatment of infectious diseases and methods of treating such diseases. The compounds and compositions include derivatives of clevudine. The compounds and compositions include derivatives of clevudine in combination with another antiviral agent. The compounds and compositions include derivatives of clevudine in combination with a phosphoramidate of lamivudine, adefovir, tenofovir, telbivudine, entecavir, or combinations thereof.

Substituted nucleotides and nucleosides for treating viral infections

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating viral infections, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether. The nucleotide or nucleoside is defined by Formula Ia below:

Nucleotide and nucleoside compositions and uses related thereto

Nucleotide and nucleoside compositions and uses related thereto

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

Nucleotide and nucleoside therapeutic compositions and uses related thereto

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

Devices for detection of an analyte based upon light interference

Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface in any amount selected from 0.1 nM, 0.1 ng/ml, 50 fg, and 2×10 3 organisms comprising the analyte.

Single suture structure

A suture for joining the first and second sides of a cut in body tissue, such suture having an elongated body member with a needle and thread member disposed at one end thereof and retention structure which can include adhesive to retain such body member when drawn into place in the body tissue.

Oligosialic acid derivatives, methods of manufacture, and immunological uses

The invention relates to methods of producing, and compositions comprising, an isolated alpha (2→8) or (2→9) oligosialic acid derivative bearing a non-reducing end enriched for one or more de-N-acetyl residues and resistant to degradation by exoneuraminidase. A representative production method involves: (i) treating an alpha (2→8) or (2→9) oligosialic acid precursor having a reducing end and a non-reducing end with sodium borohydride under conditions for de-N-acetylating the non-reducing end; and (ii) isolating alpha (2→8) or (2→9) oligosialic acid derivative having one or more de-N-acetylated residues and a non-reducing end that is resistant to degradation by exoneuraminidase. Isolated alpha (2→8) or (2→9) oligosialic acid derivatives that comprise a non-reducing end de-N-acetyl residue are provided, as well as antibodies specific for the derivatives, compositions comprising the derivatives, kits, and methods of use including protection against and detection of E. coli K1 and N. meningitidis bacterial infection, and in diagnosing and treating cancer.

Earth loop energy systems

Wellbore heat loop systems, fillers for bores in the systems, and methods of the use of such systems; the systems in certain aspects having a heat loop wellbore in the earth having heat loop pipe extending down to one side of a bottom member and up therefrom on another side thereof, the bottom member in certain aspects having a body with first and second bores therethrough, the second bore sized and configured for securement thereat of an end of coil tubing; and, in certain aspects, filler material around the heat loop in the wellbore with a gel material mixed with the water.

Ambient air cooled light emitting instrument

An ambient air cooled high intensity light emitting instrument in which the lamp is contained in a heat sink mounted within the housing. The housing contains a plurality of vent holes which circumscribe the heat sink. As heat from the light is conducted along the heat sink when the instrument is in use, the heat emanates into the chamber surrounding the heat sink, and rises through the vent holes to the surrounding atmosphere, generating a thermal current which replaces the departing hot air with cooler air from the atmosphere.

Endoscopic surgical clip applier

A surgical clip applier includes a handle assembly, an elongated shaft, a drive shaft, a cam pin, and an end effector. The cam pin is disposed in mechanical cooperation with the drive shaft. The end effector is disposed adjacent a distal end of the elongated shaft and includes a first jaw member and a second jaw member. The end effector is disposed in operative engagement with the drive shaft such that longitudinal translation of the drive shaft relative to the housing of the handle assembly causes the first jaw member to move toward the second jaw member. The first jaw member includes a first cam slot configured to slidingly receive the cam pin. The first cam slot defines a first portion having a first slope and a second portion having second slope.

Magnetic sensor

Apparatus and method for dividing direct current

La présente invention concerne un appareil pour diviser un courant de matériau en deux courants ou plus. L'appareil comprend un corps cylindrique (11) avec une entrée axiale et deux sorties radiales (20, 22) ou plus, espacées axialement l'une de l'autre. L'appareil comprend un rotor (12) muni d'un arbre central et comportant plusieurs pales (30) s'étendant radialement à partir de l'arbre et définissant au moins deux ensembles de chambres de réception de matériau. Chaque ensemble de chambres de réception de matériau comporte des moyens de guidage (38, 39) dirigeant tout matériau, qui entre dans les chambres dans cet ensemble particulier, vers l'extérieur, à travers une sortie spécifique (20 ou 22). Par suite de la rotation rapide du rotor, chaque ensemble de chambres de réception de matériau reçoit le matériau de l'entrée, selon un rapport de débits relatifs prédéterminé, et guide ce matériau vers l'extérieur à travers une sortie particulière. Application notamment aux raffineurs de pâte. The present invention relates to an apparatus for dividing a stream of material into two or more streams. The apparatus comprises a cylindrical body (11) with an axial inlet and two or more radial outlets (20, 22), axially spaced from each other. The apparatus includes a rotor (12) with a central shaft and having a plurality of blades (30) extending radially from the shaft and defining at least two sets of material receiving chambers. Each set of material receiving chambers has guide means (38, 39) directing any material, which enters the chambers in that particular set, outward, through a specific outlet (20 or 22). As a result of the rapid rotation of the rotor, each set of material receiving chambers receives material from the inlet, at a predetermined relative flow rate ratio, and guides that material outwardly through a particular outlet. Application in particular to pulp refiners.

Hepatitis e virus peptide antigens and antibodies

Immunogenic peptides derived from the ORF1, ORF2 and ORF3 regions of hepatitis E virus (HEV), diagnostic reagents containing the peptide antigens, vaccine compositions containing the antigens, and antibodies which are immunoreactive with the antigens are disclosed.

Molecular mimetics of meningococcal b epitopes

Molecular mimetics of unique epitopes of Neisseria meningitidis serogroup B ("MenB") are disclosed. Compositions containing such molecular mimetics can be used to prevent MenB or E. coli K1 disease without the risk of evoking autoantibody responses.

Method and apparatus for uprating and controlling a solid fuel pulverizer and exhauster system for a steam generator

A method for retrofitting a solid fuel pulverizer and exhauster system includes replacing the bowl drive motor 38 with a new drive motor which is operable to drivingly rotate the bowl 12 at the pre-retrofit speed but which provides relatively more horsepower than the replaced bowl drive motor 38 and replacing the original exhauster fan coupling with a new exhauster fan gear set 46, 48 which effects rotation of the exhauster fan 30 at a relatively higher rotational speed than the pre-retrofit speed. A solid fuel pulverizer and exhauster system of the present invention acting in cooperative association with a fuel-fired steam generating power plant includes an exhauster fan transmission assembly 50, 52 operable to translate the rotation of the drive shaft 54 of the exhauster fan drive motor 44 through ninety (90) degrees to thereby effect rotation of the fan by the exhauster fan drive motor 44.

Phosphoramidates for the treatment of hepatitis b virus

Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.

Multilayer Coextruded Films Including Frangible Intralaminar Bonding Forces

Compound battery set

Integrated process for producing xylenes and high purity benzene

Processes and apparatus are provided that provide high yields of xylenes per unit of aromatic-containing feed while enabling a high purity benzene co-product to be obtained without the need for an extraction or distillation to remove C 6 naphthenes. The processes of this invention include a transalkylation section and a disproportionation section in the benzene and toluene-containing feed is directly provided to the transalkylation section and in which a benzene recycle loop in the transalkylation section isolates the disproportionation section from C 6 naphthenes.

Method and apparatus for uprating and controlling a solid fuel pulverized and exhauster system for a steam generator

A method for retrofitting a solid fuel pulverizer and exhauster system includes replacing the bowl drive motor 38 with a new drive motor which is operable to drivingly rotate the bowl 12 at the pre-retrofit speed but which provides relatively more horsepower than the replaced bowl drive motor 38 and replacing the original exhauster fan coupling with a new exhauster fan gear set 46, 48 which effects rotation of the exhauster fan 30 at a relatively higher rotational speed than the pre-retrofit speed. A solid fuel pulverizer and exhauster system of the present invention acting in cooperative association with a fuel-fired steam generating power plant includes an exhauster fan transmission assembly 50, 52 operable to translate the rotation of the drive shaft 54 of the exhauster fan drive motor 44 through ninety (90) degrees to thereby effect rotation of the fan by the exhauster fan drive motor 44.

Phosphoramidates for the treatment of hepatitis b virus

Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists

Flowcell systems for single molecule detection

The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.

Hot gas device

A closed-system hot gas device for flotation in the atmosphere having a rigid cap and flexible sides with an interior gas-heating element.

Phosphoramidates for the treatment of Hepatitis B virus

Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.

Devices and methods for detection of an analyte based upon light interference

N4-hydroxycytidine and derivatives and anti-viral uses related thereto

This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of human coronavirus 2019-nCoV.

Shelf stable, pref. flexible, electrochemical heating device - contg. metal anode chips coated with cathode metal in electrolyte

A shelf-stable electrochemical heating device consists of a container, pref. a flexible envelope, contg. 100 mol. pts. metal pieces acting as the anode, a water-soluble salt to provide a conductivity of >=0.05 mhos/cm when dissolved in 500 mol. pts. water and, as the cathode, electrically conductive metal coatings covering 15-85% of the surface area of the anode pieces and/or pref. >=0.25 mol. pts. of a plating salt which reacts with the anode pieces to form a metal coating on the pieces. At least 60% of the heat produced, after mixing the reactants and formation of the conductive soln., is produced by electrochemical reactions including redn. of water to OH- ions and hydrogen ions at the cathode and oxidn. of the anode metal pieces. Device produces a large amt. of heat rapidly and maintains the heat for >=1 hr.

Density phase separation device

Un dispositivo para separar una muestra de líquido fluido dentro de un recipiente de recogida, que comprende: un separador (540) que tiene una forma generalmente de esferoide, el separador (540) comprende: un flotador (542), que tiene una primera densidad; y un la (544) que tiene una segunda densidad mayor que la primera densidad, al menos una parte del flotador (542) se conecta a al menos una parte del lastre (544) en una interfaz, caracterizado porque el flotador (542) incluye una hendidura (548) o una pluralidad de hendiduras (548) adyacentes a la interfaz con el lastre (544), el separador (540) define un orificio pasante (546) que se extiende a través del separador (540) y que comprende una primera abertura y una segunda abertura, el orificio pasante adaptado para permitir que pase fluido a través del separador (540), el orificio pasante (546) se define a lo largo de un eje pasante y el flotador (542) se adapta para deformación en una dirección perpendicular al eje pasante al aplicar la fuerza de rotación al separador (540), el separador (540) se adapta para transitar desde una primera posición inicial en la que el orificio pasante (546) se orienta en una posición de apertura para permitir que pase fluido a través del mismo, a una segunda posición de sellado para evitar que se reciba fluido a través del mismo, al aplicar una fuerza de rotación, y la transición del orificio pasante (546) desde la posición de apertura a la posición de cierre coincide con la rotación del separador mecánico (540) desde la primera posición inicial a la segunda posición de sellado. A device for separating a fluid sample within a collection container, comprising: a separator (540) having a generally spheroid shape, the separator (540) comprising: a float (542), having a first density ; and a la (544) having a second density greater than the first density, at least a part of the float (542) is connected to at least a part of the ballast (544) at an interface, characterized in that the ...

Charge switch nucleotides

The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.

Optical test platform

Provided herein are an optical test platform and corresponding method of manufacturing the same. The test platform may include a shell defining a cavity for receiving a sample tube, a first aperture, and a second aperture. The first aperture and the second aperture of the shell may each be configured to optically couple the cavity with an exterior of the shell. The test platform may further include a first window and a second window embedded in the shell. The first window may seal a first aperture and the second window may seal a second aperture. The first window and second window may each permit the optical coupling of the cavity with the exterior of the shell. The first window and the second window may be optically coupled via the cavity, and the shell may prohibit optical coupling between the first window and the second window through the shell.

Phosphoramidates for the treatment of hepatitis b virus

Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.

Hepatitis E virus ORF Z peptides

An antigen composition hepatitis E virus (HEV) infection are disclosed. The antigen composition includes peptides corresponding to carboxyl terminal end regions of the second and third open reading frames of the HEV genome.

Purification process for aromatic dicarboxylic acids

Disclosed is a process for the purification of aromatic dicarboxylic acids in which the salt of an aliphatic diamine and an aromatic dicarboxylic acid is formed in an aqueous solvent, recrystallized, and contacted with an aliphatic dicarboxylic acid in an aqueous solvent such that the aromatic dicarboxylic acid is recoverable in the form of a purified precipitate. The remaining aqueous solute is a salt of the aliphatic diamine and aliphatic dicarboxylic acid and can be used as a starting material in the manufacture of certain polyamides (nylons). The invention is particularly applicable for purifying 2,6-naphthalene dicarboxylic acid, which is difficult otherwise to purify.

Electrically conductive thermoplastic compositions

Thermoplastic compositions containing reinforcing agents or fillers and carbon black, and made by a specific procedure are described. In certain instances when the reinforcing agents or fillers are more restricted, and other ingredients are present, electrically conductive compositions with very smooth surfaces, and suitable for auto panels and other uses wherein the part may be painted, are described. Also described are the processes of making such compositions, especially when a conductive filler is carbon black. Such compositions are useful for items such as appliance parts, automotive body panels, power tool housings, and electrical and electronic housings.

Superconductive geomagnetic craft

A craft (10) that includes superconductive materials (12) that are supported within the geomagnetic field of the earth by means of the Meissner effect. The craft (10) is propelled by means of directing a current from a point to another therein which creates a propelling force thereon within the geomagnetic filed as determined by the right-hand motor rule.

Hot edge ring with sloped upper surface

A hot edge ring with extended lifetime comprises an annular body having a sloped upper surface. The hot edge ring includes a step underlying an outer edge of a semiconductor substrate supported in a plasma processing chamber wherein plasma is used to process the substrate. The step includes a vertical surface which surrounds the outer edge of the substrate and the sloped upper surface extends upwardly and outwardly from the upper periphery of the vertical surface.

Two stage diafiltration method and apparatus

Electrical connector assembly incorporating printing circuit board

Phosphoramidates for the treatment of hepatitis b virus

Disclosed are compounds and compositions to the treatment of infectious diseases and methods of treating such diseases. The compounds and compositions include derivatives of clevudine. The compounds and compositions include derivatives of clevudine in combination with another antiviral agent. The compounds and compositions include derivatives of clevudine in combination with a phosphoramidate of lamivudine, adefovir, tenofovir, telbivudine, entecavir, or combinations thereof.

Rotating shaft support assembly for a bowl mill

A pulverizes shaft rotation support assembly (10) includes a rolling element sub-assembly (18) for rotationally supporting the shaft (12) of a pulverizes (14) of a bowl mill (16) of the type which is operative for pulverizing material such as coal into smaller particles, and includes a separator body (24) having a bore, a rotating shaft (12) supported within the bore, and a grinding table (26) supported on the shaft (12). The rolling element sub-assembly (18) includes an inner race (30) secured to the shaft (12) at a first shaft location (FL), an outer race (32) and a plurality of cylindrical bearings (34) for rolling movement along and intermediate the inner (30) and outer (32) races. The pulverizes shaft rotational support assembly (10) also includes an annular cutout (40) in a gearbox housing structure (36) for radially limiting the outer race (32) while permitting axial movement thereof. The annular cutout (40) limits the maximum radial displacement of the outer race (32) to thereby maintain an annular clearance between the shaft (12) and the bore (CB) while permitting axial following movement of the outer race (32) in correspondence with axial movement of the inner race (30), whereby the shaft (12) can freely rotate out of contact with the bore (CB) throughout the range of axial movement of the shaft (12) during axial loading thereof.

N4-hydroxycytidine and derivatives and anti-viral uses related thereto

This disclosure relates to N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment and prophylaxis of viral infections.

Hepatitis e virus peptide antigens and antibodies

Sont décrits des peptides immunogéniques dérivés des régions ORF1, ORF2 et ORF3 du virus de l'hépatite E (HEV), des réactifs diagnostiques contenant ces antigènes peptidiques, des compositions de vaccins renfermant ces antigènes, et des anticorps qui sont immunoréactifs avec lesdits antigènes. Described are immunogenic peptides derived from the hepatitis E virus (HEV) ORF1, ORF2 and ORF3 regions, diagnostic reagents containing these peptide antigens, vaccine compositions containing these antigens, and antibodies which are immunoreactive with said antigens.

Method for detecting truck dump occurrences

The present invention is adapted to provide a method for identifying a machine dump occurrence of an earthmoving machine. The method includes determining an initial elevation of a point on the machine. The elevation of the point is then monitored to determine when a dumping threshold is exceeded. The ground speed is also monitored to determine if the machine 102 is moving at a speed indicative of dumping. When the machine speed is below a dumping speed, and the receiver 116 has exceeded a dumping threshold the machine 102 may be determined to have dumped its load.

Heparan sulfate biosynthesis inhibitors for the treatment of diseases

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

Density phase separation device

A mechanical separator (40) for separating a fluid sample into first and second phases within a collection container (82) is disclosed. The mechanical separator (40) has a separator body with a through-hole (46) adapted for allowing fluid to pass through. The separator body includes a float (42), having a first density, and a ballast (44), having a second density greater than the first density. The body also includes a seal between the separator (40) and the container (82). In use the separator changes position in a centrifuge from a position in which fluid can flow (F) through the hole to a closed position.

Extruded plastics wall panel and door panel construction system

A modular construction system that utilizes an extruded wall panel formed from rigid PVC to form either a door system, a wall system, or a storage building. The construction system includes an extruded wall panel defined by planar front and back surfaces that define a hollow interior. The wall panel can be configured to act as a door panel for a modular door system. A plurality of wall panels can be joined by a panel adapter to define a wall having a user selected configuration. Further, the wall panels can be joined to define the sidewalls of a storage building. An eave connector formed from extruded plastic supports a series of wall panels on the sidewalls and cooperates with a roof connector to form the roof of the storage building from the extruded wall panels.

Compounds and methods of treating brain disorders

Nitrated and non-nitrated compounds capable of protecting brain tissue from injury and useful as therapeutic agents to treat neurodegenerative diseases and conditions are disclosed. Methods of using the compounds in therapeutic treatments, and methods of preparing the compounds, also are disclosed.

METHOD FOR GENETIC CONTROL OF INFESTATIONS BY INSECTS IN PLANTS, AND DERIVATIVE COMPOSITIONS

La presente invención se refiere al control de infestación por pestes mediante la inhibición de una o más funciones biológicas. La invención proporciona métodos y composiciones para tal control, mediante alimentación a la peste con una o más moléculas de ARN bicatenario recombinante provistas por la invención; una reducción en la infestación por peste se obtiene por la supresión del gen de expresión. La invención también se dirige a métodos para fabricar plantas transgénicas que expresan las moléculas de ARN bicatenaria, y a particulares combinaciones de agentes pesticidas transgénicos para uso en la protección de las plantas infestadas. The present invention relates to the control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control, by feeding the plague with one or more recombinant double stranded RNA molecules provided by the invention; A reduction in plague infestation is obtained by suppressing the expression gene. The invention is also directed to methods for manufacturing transgenic plants that express double-stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in the protection of infested plants.

Phosphoramidates for the treatment of hepatitis b virus

Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.

Rotating shaft support assembly for a bowl mill

A pulverizes shaft rotation support assembly (10) includes a rolling element sub-assembly (18) for rotationally supporting the shaft (12) of a pulverizes (14) of a bowl mill (16) of the type which is operative for pulverizing material such as coal into smaller particles, and includes a separator body (24) having a bore, a rotating shaft (12) supported within the bore, and a grinding table (26) supported on the shaft (12). The rolling element sub-assembly (18) includes an inner race (30) secured to the shaft (12) at a first shaft location (FL), an outer race (32) and a plurality of cylindrical bearings (34) for rolling movement along and intermediate the inner (30) and outer (32) races. The pulverizes shaft rotational support assembly (10) also includes an annular cutout (40) in a gearbox housing structure (36) for radially limiting the outer race (32) while permitting axial movement thereof. The annular cutout (40) limits the maximum radial displacement of the outer race (32) to thereby maintain an annular clearance between the shaft (12) and the bore (CB) while permitting axial following movement of the outer race (32) in correspondence with axial movement of the inner race (30), whereby the shaft (12) can freely rotate out of contact with the bore (CB) throughout the range of axial movement of the shaft (12) during axial loading thereof.

Removable instrument holder

A holder assembly for a medical instrument having two sections (14,16) releasably coupled together. One section (16) is mounted to a support (12) while the second section (14), which contains means (18) for holding a medical instrument, can be easily detached from the first section without the use of tools, such that the instrument holder may be sterilized along with the instrument.

Hepatitis c virus immunodiagnostic antigens and antibodies

Edge connector for a printed circuit board

A push-pull edge card electrical connector is adapted for receiving an edge of a printed circuit board having contact pads on opposite sides of the board adjacent the edge. The connector includes an elongated dielectric housing having a board-receiving face. An elongated slot is disposed in the board-receiving face generally along a longitudinal axis of the housing for receiving the edge of the printed circuit board. A plurality of pairs of transversely spaced terminal-receiving cavities are disposed on opposite sides of the slot defining two rows of cavities lengthwise of the housing. The pairs of transversely spaced cavities are separated by transverse walls extending generally perpendicular to the longitudinal axis of the housing. The housing includes side walls at each pair of transversely spaced terminal-receiving cavities, with the side walls being of different thicknesses along the length thereof to accommodate different shapes of terminals in each pair thereof. A plurality of pairs of first and second shapes of terminals are received in the transversely spaced cavities with one terminal in each pair disposed in a respective one of the transversely spaced cavities. One of the first and second shapes of terminals includes a retention section press-fit between the transverse walls adjacent the thicker of the side walls of different thicknesses. Another feature is that different length preloading walls are provided in the housing for preloading spring contact portions of the terminals.

Composite battery pack of power tool

A composite battery set of a power tool, comprising a battery, a non-polarity ultracapacitor, a switch, a motor, etc. The ultracapacitor is a non-polarity ultracapacitor, and the power released by the fully charged battery at a high discharge rate is utilized to drive a motor. As such, a switch is used to switch and connect the non-polarity ultracapacitor to the different polarities of the motor, thus achieving the switching of the rotation directions of the motor.

High-density edge card connector

A connector for an edge card includes an elongated insulative housing with a central edge card-receiving slot formed in its top surfaces between two opposing sidewalls of the housing. The housing incudes two sets of terminal-receiving cavities disposed between the two side walls. The cavities are spaced apart from each other and separated by intervening cavity walls and the cavities are open to the exterior of the connector housing at the top and bottom of the housing. Conductive terminals are inserted into the cavities, preferably from the bottom and the terminals contain contact portions that are adapted to engage confronting contact pads on the edge card. The contact portions extend through additional openings of the cavities so that part of the contact portions extend into the card-receiving slot. The housing includes two preload walls that extend the length of the housing and separate the top openings from the slot openings of the cavities.

Method and apparatus for improving visualization of biopsy needle in ultrasound imaging

A method and an apparatus for improving visualization of a needle-like instrument (54), such as a biopsy needle, inserted in a human body as described. The instrument is visualized by transmitting an ultrasound beam (56) toward the instrument (54) and then detecting the echo signals (58) using a linear array (2) of transducer elements (2'). The problem of ultrasound being reflected from a biopsy needle in a direction away from the transducer array (2) is solved by steering the transmitted ultrasound beam (56) to increase the angle at which the beam impinges upon the biopsy needle. Ideally the ultrasound beam is perpendicular to the biopsy needle. This increases the system's sensitivity to the needle because the reflection from the needle is directed closer to the transducer array. This can be accomplished using either the B mode or the color flow mode of an ultrasound imaging system.

Post-transfusion, non-a, non-b hepatitis virus and antigens

An ussd transport method and device

An USSD transporting method (200) and mobile computing device (410) are described. The method (200) can include the steps of: providing a data pushing operation (210) over a universal supplementary services data (USSD) channel from the application server to the mobile device client; and initiating a data pulling operation (220) over an internet protocol (IP) channel by the mobile device client, in response to the pushing operation. Advantageously, for short data transfers, such as application server push notifications, USSD messages require lower power drain than packet data, due to the longer time to transition to an RRC idle state after the data transfer is completed. Also, push notifications can be sent over USSD without an open IP session, thereby saving the client from having to maintain a persistent IP session, while employing alternate pulling transport means such as wireless LAN which require lower power drain than a wide area network.

Carousel for incubation station

An incubation station has a carousel for receiving a plurality of test sample cards. An even temperature and air flow distribution inside the carousel and incubation of the cards over time at the proper temperature was found to be critically dependent upon air flow characteristics within the incubation station. To optimize air flow, the carousel was given an open rear side that is exposed to an air distribution table having a cover plate placed adjacent to the rear surface of the carousel. The cover plate has a plurality of elongate slots positioned in a symmetrical ring-shaped pattern in registry with the carousel. The elongate slots are positioned at an angle relative to the slots in the carousel such that each carousel slot receives air from more than one slot. An extra fan was also added to the system to increase the flow of air into the air table. Scallop features on the carousel walls also promote even distribution of air flow over the cards. The carousel may be divided into a plurality of carousel segments to increase ease of removal and insertion of the carousel into the incubation station and manufacturability of the carousel.

Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis

The present invention generally provides methods and vaccines for the prevention of diseases caused by Neisseria meningitidis bacteria, particularly serogroup B strains.

Extruded wall panel system and method of forming

A wall member useful in forming a wall panel system includes a pair of outer walls held spaced apart and fixed together at a pair of opposed side edges, one of the side edges being provided with a first connecting structure and the other of the side edges being provided with a second connecting structure. The first and second connecting structure includes a number of projections secured to and extending outwardly from the side edges and constructed with snap fit elements separately located from the outer walls. The wall member is adapted to be joined to an adjacently disposed wall member of similar structure by direct snap fit mating engagement between one of the first and second connecting structure at one of the second edges of the wall member and the other of the first and second connecting structure on a facing side edge of the adjacently disposed wall member.

Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis

The present invention generally provides methods and vaccines for the prevention of diseases caused by Neisseria meningitidis bacteria, particularly serogroup B strains.

Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions

The present invention provides compounds of the formula which are activators of glucokinase activity and, thus, may be employed as therapeutic agents for the treatment of glucokinase mediated conditions. Accordingly, the compounds of formula (I) may be employed for the prevention and the treatment of impaired glucose tolerance, Type 2 diabetes and obesity.

Hmg co-a reductase inhibitor enhancement of bone and cartilage

Multilayer Coextruded Films Including Frangible Intralaminar Bonding Forces

Energy conservation in heavy-hydrocarbon distillation

An aromatics complex producing one or more xylene isomers offers a large number of opportunities to conserve energy by heat exchange within the complex. One previously unrecognized opportunity is through providing two parallel distillation columns operating at different pressures to separate C 8 aromatics from C 9 + aromatics. The parallel columns offer additional opportunities to conserve energy within the complex through heat exchange in associated xylene recovery facilities.

Mixtures and Methods for Producing Pharmacologically Active Preparations and Uses thereof

' Det beskrives farmakologisk aktive forbindelser som er i stand til å binde til nukleærhormonreseptorer, og som er egnet til stimulering av osteoblastproliferasjon og i neste omgang til benvekst. Det beskrives også anvendelsen av slike forbindelser til behandling eller forhindring av sykdommer og/eller forstyrrelser assosiert med nukleærhormonreseptor-familier.

Egr valve position control system

An EGR valve position control system includes an EGR valve manager responsive to an EGR valve command to drive an EGR valve actuator. The EGR valve manager is operable ot schedule control gains as a function of valve actuation direction to provide for faster response during valve closing events. Valve closing events are also staged such that a large valve position step is followed by a steady ramp to the valve closed position to thereby prevent damage to the valve and/or valve seat. The EGR valve manager further includes a prioritized switching feature for strategically switching between closed and open loop control modes, and a forward gain adjustment feature responsive to battery voltage to maintain constant system DC gain under changing battery voltage conditions.

Fabrication of multi-segment spars

Systems and methods are provided for fabricating multiple segment spars for an aircraft. In one example the method includes fabricating preforms of fiber reinforced material for spar segments, hardening the preforms to form the spar segments, and bonding the spar segments together to form a completed spar detail. In addition to bonding, other examples include co-curing and fastening the spar segments. In additional examples, the spar segments include kinks or sub-kinks as described.

Method of art instruction

A system for teaching artistic methods and techniques by providing both images on a television screen and instructional data and providing means for copying the image on a sheet of clear or translucent material place on a portion of the television screen.

Accelerometer-based systems and methods and quantifying steps

Systems and methods detect steps from one or more sensed accelerometer signals. Systems comprise an accelerometer and a non-transitory computer readable medium, each of which communicates with a processor. The accelerometer is coupled to an individual and generates outputs received by the processor. The non-transitory computer readable medium stores instructions controlling the processor to perform steps of a method. The processor determines a minimum and a maximum reading for respective time periods. Counted peak heights are maxima that exceed a rest threshold. The rest threshold may be a function of the rest maximum. The processor determines a peak threshold for each time period having a counted peak height. A counted amplitude comprises the difference between the maximum reading and minimum readings of a time period in which the counted peak height exceeds the peak threshold. The processor increments a step counter when a counted amplitude exceeds an amplitude threshold.

Oil separator for vehicle air system

An oil separator for use in a vehicle air system includes a recycling valve for removing coalesced oil. The recycling valve may include a piston movable in a cylinder in response to a control air pressure to open the recycling valve and thus drain coalesced oil from a sump under the influence of residual air pressure in the sump. The separator may include a fixture for mounting the separator to a vehicle, including a plurality of ports extending from an inlet port for directing air into the cartridge with a combined flow area at least equal to the flow area of the inlet port. The plurality of ports preferably extend at a right angle to the direction of flow of air through the inlet port. A safety relief valve on the separator releases air when the pressure exceeds a predetermined pressure.

Indole-type inhibitors of p38 kinase

The invention is directed to inhibition of p38-.alpha. kinase using compounds of formula (I) and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein Ar is an aryl group substituted with 0-5 non-interfering substituents, wherein two adjacent noninterfering substituents can form a fused aromatic or nonaromatic ring; L1 and L2 are linkers; X is an aliphatic monocyclic or aliphatic polycyclic moiety optionally comprising one or more hetero ring atoms wherein the cyclic moiety may be optionally substituted with one or more noninterfering substituents and where said optional substituents may constitute a ring fused to X; n is 0-3; each R1 is hydrogen or a noninterfering substituent; (2) represents a single or double bond; one Z2 is CA or CR2A; the other Z2 is CR3, CR32, NR4 or N; and each R2, R3 and R4 is independently hydrogen or a noninterfering substituent; Z3 is NR5 or O; where R5 is hydrogen or a noninterfering substituent.