LOCK WITH EMERGENCY DICKEY

Device for locking and unlocking door for emergency evacuation in building, has bolts actuated by key and handle such that bolts moved from locking position to unlocking position when handle is moved from rest position to actuated position

Dispositif (1) de verrouillage pour le verrouillage et le déverrouillage d'une porte permettant une évacuation d'urgence, comprenant - un boitier (111) ; et - une poignée d'urgence (12) ; dans lequel un pêne (14) à actionnement par clef et un pêne (13) à actionnement par poignée sont agencés à l'intérieur du boitier (111), caractérisé en ce que la poigné d'urgence (12) est couplée au pêne (14) à actionnement par clef et au pêne (13) à actionnement par poignée de manière à ce que : le pêne (14) à actionnement par clef et le pêne (13) à actionnement par poignée sont déplacés d'une position de verrouillage vers une position de déverrouillage lorsque la poignée d'urgence (12) est déplacée de sa position de repos vers sa position actionnée suite à une pression sur la poignée d'urgence suivant une direction (12D) de poussée sensiblement normale à la porte (21) lorsque le dispositif (1) est monté sur la porte (21).

FAST DEVICE OF COUPLING WITH DOUBLE ELEMENTS OF HOOKS

ELECTROMECHANICAL LOCK

PROCESS AND ELEVATOR OPERATING SYSTEM ACCOMODATING OF the VISUALLY HANDICAPPED PERSONS AT THE TIME DECANALISATION OF ASCENDING TRAFFIC IN PEAK PERIOD

GAS TURBINE AND A METHOD FOR MAKING FUNCTION THIS ONE

Procédé pour faire fonctionner une turbine à gaz (10) comprenant un ensemble haute pression (40), un ensemble de soufflante (16) pour mettre de l'air sous pression, un conduit (46) de courant d'ensemble haute pression, un conduit intérieur de dérivation (60) et un conduit extérieur de dérivation (58). Le procédé comprend des étapes consistant à canaliser une première partie de l'air refoulée depuis l'ensemble de soufflante via la turbine à gaz d'ensemble haute pression, canaliser une deuxième partie de l'air refoulée depuis l'ensemble de soufflante via le conduit intérieur de dérivation de telle sorte que la deuxième partie de l'air contourne la turbine à gaz d'ensemble haute pression, mélanger l'air d'échappement de la turbine à gaz d'ensemble haute pression et la deuxième partie de l'air, canaliser l'air mélangé via un distributeur (110) d'ensemble haute pression, et canaliser une troisième partie de l'air refoulée depuis l'ensemble de soufflante via un distributeur de dilution (112).

AMPLIFIER OF POWER FOR SYSTEMS OF TRANSMISSION RADIO FREQUENCIES

BROAD BAND AMPLIFIER HF COMPRISING A SYSTEM OF REDUCTION OF DISTORTION AND PROCESS OF REDUCTION OF DISTORTION ASSOCIATES

ELECTROMECHANICAL BOLT

L'invention porte sur un système de verrou comprenant une tige amovible (200) destinée à être insérée dans un dispositif d'ancrage (100), dans lequel le dispositif d'ancrage (100) comprend une came de positionnement (130) sur laquelle un pêne (120) monté en translation est destiné à venir en appui, ce pêne (120) étant destiné à coopérer avec la tige amovible pour un verrouillage du système, la came de positionnement (130) étant montée dans le boitier (110) en rotation selon un axe de rotation parallèle à l'axe d'insertion de sorte que la rotation de la came de positionnement définit : - une position de verrouillage dans laquelle la came de positionnement (130) empêche une translation du pêne (120) dans un sens opposé au sens de déploiement du pêne dans une gorge ménagé dans la tige amovible ; et - une position de libération dans laquelle la came de positionnement (130) ne s'oppose pas à la translation du pêne (120) dans le sens opposé au sens de déploiement.

TURBOPROPELLER DOUBLES FLOW

TURBOPROPELLER DOUBLES FLOW

Un moteur à turbopropulseur à cycle variable (10) comporte une première et une seconde soufflante (14, 16) reliées indépendamment à des turbines respectives (26, 24). Un premier conduit secondaire (46) entoure un générateur de gaz disposé en communication par écoulement avec la seconde soufflante (16). Un second conduit secondaire (48) entoure le premier conduit secondaire (46) en communication par écoulement avec la première soufflante (14). Une première tuyère d'éjection (66) est reliée à la fois au générateur de gaz et au premier conduit secondaire (46). D'autre part, une seconde tuyère d'éjection (68) est reliée au second conduit secondaire (48).

POLYMERISIERBARE BIOLOGISCH ABBAUBARE POLYMERE MIT CARBONAT-ODER DIOXANONBINDUNGEN

RAUCHMELDER

用于治疗IgE相关性疾病的组合物

The present invention provides methods of treating IgE-associated disorbers and products for use therein. The methods comprise administering to a subject an amount of a first composition comprising an immunogenie antigen and an amount of a second composition that inhibits the activity of IgE. The methods are particularly useful in treatment of allergies such as allergic rhinitis. These combination methods offer significant advantages, such as improving the efficacy of therapy while showing a good safety profile.

Method of process controller optimization in multivariable predictive controller

METHOD AND SYSTEM FOR IMPLEMENTING WORKFLOWS AND MANAGNG STAFF AND ENGAGEMENTS

The present invention relates to software and a method of use for implementing workflows and managing engagements and staff. More particularly, the present invention relates to a software module tracking data of staff, engagements and workflows and a method of using such data in the management of staff and assignment of tasks. Information concerning employees is input into a database by the manager and the employees, and is tracked therein. The information concerning an employee includes an employee's availability, ability and experience. Workflow/Task information is input into the database when either a client makes a request for service of the business, or a workflow/task internal to the business is needed to be performed. Task information includes the nature of the work and deadlines. Task information is compared to the employee information. A list is automatically generated naming the employees best suited to the mandate of the task. The manager then chooses a name from the top of the list and assigns the task to that employee. 1. A method for determining staffing decisions in providing professional services , the method comprising:a. storing at a database a set of work related data, the set of work related data including skill data, availability data, and client data;b. automatically tracking work related data, other than availability data, for a plurality of individuals;c. based at least in part on work related data other than availability data, assigning a task to a set of individuals, the task associated with delivery of professional services.2. The method of claim 1 , wherein work related data includes work schedule data claim 1 , and the method further comprising automatically updating an individual's work schedule data to reflect a task assigned in the assigning step.3. The method of claim 1 , wherein work related data includes time and billing data claim 1 , and the method further comprising receiving an input related to entry of time and billing data ...

PICOLINAMIDO-PROPANOIC ACID DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS

The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity. 2. A compound as in claim 1 , wherein{'sup': '1', 'sub': 2', '3, 'Lis selected from the group consisting of —CH—, —CH(CH)— and —C(O)—;'}a is an integer from 0 to 2;{'sup': '1', 'sub': 1-4', '1-4', '1-4', '1-2', '2', '1-2', '3-6', '5-6, 'each Ris independently selected from the group consisting of halogen, hydroxy, cyano, Calkyl, fluorinated Calkyl, Calkoxy, fluorinated Calkoxy, —SO—Calkyl, phenyl, Ccycloalkyl and Ccycloalkenyl;'}b is an integer from 0 to 2;{'sup': '2', 'sub': 1-4', '1-2', '1-2', '1-2, 'each Ris independently selected from the group consisting of halogen, cyano, Calkyl, fluorinated Calkyl, Calkoxy and fluorinated Calkoxy;'}c is an integer from 0 to 3;{'sup': '3', 'sub': 1-4', '1-2', '1-4', '1-2', '1-2, 'each Ris independently selected from the group consisting of halogen, Calkyl, fluorinated Calkyl, Calkoxy, fluorinated Calkoxy and —C(O)—Calkyl;'}or a pharmaceutically acceptable salt thereof.3. A compound as in claim 2 , wherein{'sup': '1', 'sub': 2', '3, 'Lis selected from the group consisting of —CH—, —CH(CH)— and —C(O)—;'}a is an integer from 0 to 2;{'sup': '1', 'sub': 1-4', '1-2', '1-2', '2', '1-2', '3-6, 'each Ris independently selected from the group consisting of halogen, hydroxy, cyano, Calkyl, fluorinated Calkyl, Calkoxy, —SO—Calkyl, phenyl, Ccycloalkyl and cyclohexenyl;'}b is an integer from 0 to 2;{'sup': '2', 'sub': 1-2', '1-2', '1-2, 'each Ris independently selected from the group consisting of halogen, cyano, Calkyl, fluorinated Calkyl and Calkoxy;'}c is an integer from 0 to 2;{'sup': '3', 'sub': 1-2', '1-2', '1-2', '1-2', '1-2, 'each Ris independently selected from the group consisting of halogen ...

Flexible mask attachment for a patient interface device

A patient interface device ( 10 ) that includes a mask ( 12 ) and a headgear component ( 18 ) for attaching the patient interface device to the head of a patient. The headgear component includes a strap ( 20 ) and an attachment element ( 22, 40, 60, 80 ) provided between the mask and the strap. The attachment element has a mask attachment portion ( 24, 42, 62, 82 ) coupled to the mask, a strap attachment portion ( 26, 44, 64, 84 ) coupled to the strap, and a flexible linkage portion ( 28, 46, 66, 86 ) provided between the mask attachment portion and the strap attachment portion. The flexible linkage portion is more flexible than both the mask attachment portion and the strap attachment portion to enable the mask attachment element to flex, bend, and/or twist along multiple axes to conform to particular facial contours of the patient.

NOVEL METHOD OF COMBINED MOLECULAR CLAMPING AND ALLELE SPECIFIC qPCR TECHNOLOGY FOR KRAS G12C MUTATION DETECTION

The invention provides a method for detecting KRAS mutations at one or more of codons, said method comprising the steps of: (a) extracting DNA from a biological sample; (b) assaying the DNA via PCR for KRAS mutations at one or more of codons with at least one set of oligonucleotides, wherein the at least one set of oligonucleotides comprises an allele specific forward primer, a reverse primer, a probe and a xenonucleic acid clamp to block amplification of wild type DNA. The xenonucleic acid clamps have aza-aza, thio-aza and oxy-aza chemical functionality. 1. A method of detecting KRAS mutations at one or more of codons; said method comprising: (a) providing a biological sample; (b) isolating DNA from said biological sample; said DNA including said KRAS mutations; (c) providing a first primer primer probe which is allele specific and a second primer probe; wherein said first and second primer probes are targeted to said KRAS mutations and wherein said primer probes allow formation of a PCR process product; (d) providing a target specific xenonucleic acid clamp oligomer probe specific for a wildtype polynucleotide sequence; so that during the qPCR process only mutant templates are amplified; (e) admixing the primer probes and the xenonucleic acid clamping probe with the target nucleic acid sample; (f) performing a PCR amplification process in a reaction solution under hybridization conditions thereby generating multiple amplicons; and (g) detecting said amplicons.2. The method of claim 1 , wherein the biological sample is obtained from a human or animal subject diagnosed with cancer.3. The method of claim 1 , wherein the biological sample is selected from the group consisting of formalin-fixed paraffin embedded (FFPE) tissue claim 1 , fresh frozen tumor specific tissue claim 1 , circulating tumor cells claim 1 , circulating cell-associated DNA from plasma claim 1 , and circulating non-cell associated DNA from plasma.4. The method of claim 1 , wherein the biological ...

SPECIFIC SYNTHETIC CHIMERIC XENONUCLEIC ACID GUIDE RNA; s(XNA-gRNA) FOR ENHANCING CRISPR MEDIATED GENOME EDITING EFFICIENCY

The invention provides specific synthetic chimeric xenonucleic acid guide RNA; s(XNA-gRNA) for enhancing crispr mediated genome editing efficiency. The invention also provides methods and compositions for inducing CRISPR/Cas-based gene editing/regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using single guide RNAs (sgRNAs) that have been chemically modified with xeno nucleic acids which enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a sgRNA that has been chemically modified with xeno nucleic acids to correct a mutation in a target gene associated with the genetic disease. 1. RNA modified with a linker and a xenonucleic acid wherein said xenonucleic acid has functionality selected from the group consisting of azide , oxaaza and aza.2. The modified RNA of claim 1 , wherein said RNA is sgRNA.3. The modified RNA of claim 1 , wherein said RNA is crRNA.4. The modified RNA of claim 1 , wherein said RNA is tracrRNA.5. The modified RNA of claim 1 , having the formula:6. The modified RNA of claim 1 , wherein said RNA is chimeric.7. A method for inducing gene regulation of a target nucleic acid in a primary cell claim 1 , the method comprising: introducing into the primary cell:(a) a xenonucleic acid modified single guide RNA (sgRNA) comprising a first nucleotide sequence that is complementary to the target nucleic acid and a second nucleotide sequence that interacts with a CRISPR-associated protein (Cas) polypeptide, wherein one or more of the nucleotides in the first nucleotide sequence and/or the second nucleotide sequence are nucleotides which have been chemically modified with xenonucleic acids; and(b) a Cas polypeptide, an mRNA encoding a ...

AUTOMATED EVALUATION OF TEST LOGS

An automated evaluation of test logs for the testing of telecommunications equipment includes a probabilistic model that links possible events in a test log with possible causes for the event. Probability values for possible causes are calculated from the probabilistic model and a search result, and a reference to a possible cause is provided in an output based upon the calculated probability values. 1. A method for the automated evaluation of a test log for testing telecommunications equipment , the method comprising steps:providing a probabilistic model, which links a plurality of possible events in the test log with a plurality of possible causes;searching the test log for the occurrence of at least one of the possible events;calculating probability values for the plurality of possible causes with the probabilistic model and a search result; andproviding an indication of at least one possible cause for the at least one of the possible events in the test log based on the calculated probability values.2. The method according to claim 1 , further comprising assigning a predefined probability value to at least one link in the probabilistic model claim 1 , which is used for the calculation of the probability values for the plurality of possible causes.3. The method according to claim 1 , wherein each link associates one event with one possible cause claim 1 , and precisely one probability value is allocated to each link.4. The method according to claim 1 , wherein each event is linked to all possible causes that are represented in the probabilistic model.5. The method according to claim 1 , wherein the probabilistic model comprises a Bayesian network claim 1 , a neural network claim 1 , and/or a decision tree.6. The method according to claim 1 , wherein the plurality of events relate to the occurrence or nonoccurrence of at least one message claim 1 , the occurrence or non-occurrence of a parameter in a message claim 1 , and/or the occurrence or non-occurrence of a ...

TEST UNIT AND TEST METHOD FOR EFFICIENT TESTING DURING LONG IDLE PERIODS

A test unit for testing a plurality of communications devices is provided. The test unit comprises a test case database, which stores a first test case (including a first test case idle time) and a second test case. The second test case is shorter than the first test case idle time. The test unit comprises a signaling unit. The test unit comprises a test case execution manager, which reads from the test case database the first and second test case and controls the signaling unit to perform measurements according to the first test case on the first device under test until a beginning of the first test case idle time, and controls the signaling unit to perform measurements according to the second test case on the second device under test during the first test case idle time. 1. A test unit for testing at least a first communication device and a second communication device , comprising:a test case database, configured to store at least a first test case, comprising a first test case idle time, and a second test case, wherein the duration of the second test case is shorter than the first test case idle time,a signaling unit, connected to at least the first device under test and the second device under test.2. The test unit according to claim 1 , further comprising:a test case execution manager configured to read, from the test case database, at least the first test case and the second test case, to control the signaling unit to perform measurements according to the first test case on the first device under test, until a beginning of the first test case idle time, and to control the signaling unit to perform measurements according to the second test case on the second device under test during the first test case idle time.3. The test unit according to claim 2 , wherein:the test unit is configured for testing a third device under test;the test case database is configured to store a third test case;the duration of the second test case in addition to the third test case is ...

Gravity Fed Smoker

A gravity fed smoker includes a smoking enclosure and an external stack. The stack is double walled with an inner wall, and an outer wall. A vented cooling space exists between the inner wall and the outer wall. An inner chamber of the external stack includes a fire box with a fire grate and a feed hopper positioned above the fire box. A smoke tunnel with a series of openings for releasing smoke into the smoking enclosure extends along the bottom of the food smoking enclosure and is connected to the external fire box at one end. Fuel, including charcoal, lump coal, or wood pellets, is loaded into the feed hopper. As the fuel burns on the fire grate and turns to ashes, the fuel is fed from the hopper onto the fire grate by gravity. A fan and dampers controls air flow through the fire grate and into the smoke tunnel.

Providing external access to a processing platform

An apparatus, and a method, performed by one or more processors are disclosed. The method may comprise receiving a build request associated with performing an external data processing task on a first data set, the first data set being stored in memory associated with a data processing platform to be performed at a system external to the data processing platform. The method may also comprise generating a task identifier for the data processing task, and providing, in association with the task identifier, the first data set to an agent associated with the external system with an indication of the data processing task, the agent being arranged to cause performance of the task at the external system, to receive a second data set resulting from performance of the task, and to provide the second data set and associated metadata indicative of the transformation. The method may also comprise receiving the second data set and metadata from the agent associated with the external system and storing the second data set and associated metadata.

Systems and Methods for Resin Recovery in Additive Manufacturing

A method of producing multiple batches of objects by stereolithography, includes the steps of: (a) dispensing an initial or subsequent batch of dual cure resin into a stereolithography apparatus (11), the resin including a light polymerizable component and a heat polymerizable component; (b) producing an intermediate object by light polymerization of the resin in the apparatus (12), wherein the intermediate object retains excess resin on a surface thereof; then (c) separating excess resin from the intermediate object (13); (d) blending the excess resin with additional dual cure resin to produce a subsequent batch of dual cure resin (15); (e) repeating steps (a) through (c), and optionally repeating step (d), to produce additional object(s); and (f) baking the objects, together or separately, to produce multiple batches of objects (14).

DNA MUTATION DETECTION EMPLOYING ENRICHMENT OF MUTANT POLYNUCLEOTIDE SEQUENCES AND MINIMALLY INVASIVE SAMPLING

The invention relates to a method for enriching a target polynucleotide sequence containing a genetic variation said method comprising: (a) providing two primers targeted to said target polynucleotide sequence; (b) providing a target specific xenonucleic acid clamp oligomer specific for a wildtype polynucleotide sequence; (c) generating multiple amplicons using PCR under specific temperature cycling conditions; and (d) detecting said amplicons. 1. A method for enriching a target polynucleotide sequence containing a genetic variation said method comprising:(a) providing two primers targeted to said target polynucleotide sequence;(b) providing a target specific xenonucleic acid clamp oligomer specific for a wildtype polynucleotide sequence;(c) generating multiple amplicons using PCR under specific temperature cycling conditions; and(d) detecting said amplicons.2. The method of claim 1 , wherein said detection employs oligonucleotide probes specific for hybridization of variant polynucleotide amplicon sequences.3. The method of claim 1 , wherein the variant target sequence is in a gene selected from the group consisting of: KRAS claim 1 , BRAF claim 1 , EGFR claim 1 , TP53 claim 1 , JAK2 claim 1 , NPM1 claim 1 , and PCA3.4. A method for enriching multiple target polynucleotide sequences containing a genetic variation said method comprising:(a) providing a library of amplifying primers targeted to said multiple target polynucleotide sequence;(b) providing a library of target specific xenonucleic acid clamp oligomer specific for multiple wildtype polynucleotide sequences;(c) generating multiple amplicons using PCR under specific temperature cycling conditions; and(d) detecting said amplicons.5. The method of claim 3 , wherein said detection employs oligonucleotide probes specific for hybridization of variant polynucleotide amplicon sequences.6. A method for conducting a minimally invasive biopsy in a mammalian subject suspected of a having a neoplastic disease claim 3 , ...

DYNAMIC HARQ-ID RESERVATION

The method is used for detection and/or removal of errors in transmission systems which comprise a transmitter unit and at least one receiver unit. The transmitter unit transmits to the receiver unit on a semi-persistent transmission resource which provides an adjustable frequency range and an adjustable time period. Furthermore, the self-repeating, semi-persistent transmission resource repeating with the period Tis rigidly assigned to the receiver unit. Following this, at least one but not all of the HARQ process numbers available for the self-repeating, semi-persistent transmission resource are reserved for the latter. 112.-. (canceled)13. A method for detection and/or removal of errors in transmission systems , said method comprising:providing a transmitter unit and at least one receiver unit, wherein the transmitter unit transmits payload data to the at least one receiver unit on a semi-persistent transmission resource which provides an adjustable frequency range and an adjustable time period;providing a fixed assignment of a self-repeating, semi-persistent transmission resource repeating with a period TSPS to the at least one receiver unit; andproviding a reservation of at least one but not all of the HARQ process numbers available for the self-repeating, semi-persistent transmission resource.14. The method according to claim 13 , further comprising:providing a release of those HARQ process numbers which can be used for a transmission of payload data on the self-repeating, semi-persistent transmission resource but which are not reserved for the latter for at least one further transmission process from the transmitter unit to the at least one receiver unit.15. The method according to claim 13 , further comprising:providing a release of that HARQ process number for which a transmission of the payload data on the self-repeating, semi-persistent transmission resource has been successful, for at least one further transmission process from the transmitter unit to the ...

User interface for managing defects

User interfaces for managing defects are provided. A defect selection interface may include a set of defect items for selection by a user. The defect selection interface may include one or more first visuals indicating similarity of the set of defect items to other defect items. An issue selection interface may include a set of issue items for selection by the user. Individual issue items may include one or more defect items added to the individual issue items. A defect comparison interface may include a comparison of a defect item to an issue item. The defect comparison interface may include one or more second visuals indicating similarity of the defect item to the issue item. Based on the user's selection, the defect item may be added to the issue item

Oral quetiapine suspension formulations with extended shelf life and enhanced bioavailability

A quetiapine fumarate composition for oral administration is provided comprising a pharmaceutically acceptable salt or solvate of quetiapine existing as a suspension in an aqueous carrier agent. The inventive liquid formulation demonstrates high bioavailability consistent with approved dosage forms, low agglomeration, reduced content of excipients commonly used in solid oral dosage forms and extended shelf life stability. Also provided is a method of manufacturing a liquid quetiapine suspension composition for oral administration and methods of administering therapeutically effective dosages of an oral liquid quetiapine suspension composition to patients in need thereof.

Method and a test system for automatically configuring a tester

A method for automatically configuring a tester to perform functionality tests between a mobile station under test and a tester simulating a mobile communication system. The method includes receiving an identification information according to the type of the mobile station under test in the tester, retrieving characteristic parameters of the identified type of the mobile station under test from a device database by the tester, and selecting a subset of test cases which is applicable to the characteristic parameters of the identified mobile station under test from a test case database by the tester and offering the subset of test cases to generate a test program by applying one or more test cases of the selected subset. 1. A method of automatically configuring a tester to perform functionality tests between a mobile station as mobile station under test and a tester simulating a mobile communication system , the method comprising:receiving an identification information according to the type of the mobile station under test in the tester,retrieving characteristic parameters of the identified type of the mobile station under test from a device database by the tester, andselecting a subset of test cases which is applicable to the characteristic parameters of the identified mobile station under test from a test case database by the tester, and offering the subset of test cases to generate a test program by applying one or more test cases of the selected subset.2. The method according to claim 1 , further comprising configuring at least one operating parameter of the tester in accordance with the test cases of the test program and the characteristic parameters of the identified mobile station under test.3. The method according to claim 1 , further comprising evaluating a created log file of the performed test program and adapting the applied configuration of the tester and/or the selected subset of test cases according the results of the evaluation.4. The method according ...

Inverted diffuser for abrasive slurry flow with sensor for internal damages

The present disclosure is for an inverted diffuser usable in wellheads and other wellsite equipment. The inverted diffuser includes at least one first section having a first vertical inner surface, a first inclined inner surface relative to the first vertical inner surface, and one or more channels supporting one or more releasable fasteners between the at least one first section and a wall of a wellhead or of a wellsite equipment. At least one second section is press-fitted or fastened adjacent to the at least one first section. A method for application of the inverted diffuser in a wellhead and in other wellsite equipment is also disclosed, along with a method of manufacture of the inverted diffuser.

System and methods for data evaluation through network sensitivity analysis

A method for evaluating a relative contribution of a first group of J data sets in a collection of N data sets, wherein N>J, includes first applying the collection of N data sets and second applying the first group of J data sets to a model and generating one or more observations O on the collection of N data sets and the first group of J data sets, including generating a N NSA curve comprising computing, using the model, an observation O N on the collection of N data sets; and generating a N−J NSA curve for the first group of J data sets by removing the first group of J data sets from the collection of N data sets, and generating, using the model, an observation O N−J with the first group of J data sets removed. The method then includes generating a measure M J of contributions of the group of J data sets based on the N NSA curve and the N−J NSA curves.

MOBILE COMMUNICATION TEST DEVICE AND A CORRESPONDING METHOD

A mobile communication test device for testing a mobile user equipment comprises a number of transmit-receive units with a signal generator, wherein the signal generator of at least one transmit-receive unit generates test signals, which rep-resent at least two different communication partners of the mobile user equipment, a number of test interfaces, which connect the transmit-receive units with the mobile user equipment and transmit the test signals to the mobile user equipment, and a test processor, which analyses the reaction of the mobile user equipment to the transmitted test signals based on a predefined test specification. 1. A mobile communication test device for testing a mobile user equipment , the test device comprising:a number of transmit-receive units with a signal generator, wherein the signal generator of at least one transmit-receive unit generates test signals, which represent at least two different communication partners of the mobile user equipment,a number of test interfaces, which connect the transmit-receive units with the mobile user equipment and transmit the test signals to the mobile user equipment,a test processor, which analyses the reaction of the mobile user equipment to the transmitted test signals based on a predefined test specification.2. The mobile communication test device according to claim 1 , wherein the test interfaces comprise a configurable radio frequency claim 1 , RF claim 1 , unit claim 1 , which transforms the test signals generated by the signal generator into RF signals at a configurable frequency.3. The mobile communication test device according to claim 1 , wherein at least one of the test interfaces comprises a signal receiver claim 1 , which receives signals generated by the mobile user equipment and transmits the received signals to the respective transmit-receive unit.4. The mobile communication test device according to claim 3 , wherein the signal receiver is embodied in the radio frequency claim 3 , RF claim ...

PROTOCOL TEST DEVICE AND METHOD FOR OPERATING A PROTOCOL TEST DEVICE

A protocol test device for testing protocol compliance of a wireless device under test comprises a wireless interface for transmitting an outgoing RF signal to the wireless device under test and/or for receiving an incoming RF signal from the wireless device under test, a processing unit for generating messages for the outgoing RF signal based on a predefined protocol and for processing messages in the incoming RF signal based on the predefined protocol, a message log memory for storing the generated messages and the received messages, and a summary message generation unit that generates a summary log message and stores the summary log message in the message log memory, wherein the summary log message comprises information about at least one of the generated messages and/or the received messages and repetitions of the respective generated message and/or the respective received message. 1. A protocol test device for testing protocol compliance of a wireless device under test , the protocol test device comprising:a RF interface for transmitting an outgoing RF signal to the wireless device under test and/or for receiving an incoming RF signal from the wireless device under test,a processing unit for generating messages for the outgoing RF signal based on a predefined protocol and for processing messages in the incoming RF signal based on the predefined protocol,a message log memory for storing the generated messages and the received messages, anda summary message generation unit that generates a summary log message and stores the summary log message in the message log memory, wherein the summary log message comprises information about at least one of the generated messages and/or the received messages, and repetitions of the respective generated message and/or the respective received message.2. The protocol test device according to claim 1 , wherein the summary message generation unit comprises a message buffer for storing the information about predetermined types of ...

Determining maintenance for a machine

Systems, methods, non-transitory computer readable media can be configured to accessing a target sensor log corresponding to a first machine; accessing one or more prior sensor logs corresponding to the first machine and one or more prior sensor logs corresponding to a plurality of second machines which are of the same type as the first machine; accessing a plurality of computer readable logs corresponding to the first machine and the second machines, the computer readable logs for each second machine comprising a maintenance log comprising a plurality of maintenance task objects, each maintenance task object comprising a time and a maintenance task type; determining a set of statistical metrics characterising a difference between the target sensor log and each prior sensor log; selecting a sub-set of the prior sensor logs in dependence upon the statistical metrics; analysing the maintenance logs to correlate each prior sensor log included in the subset to one or more correlated maintenance tasks; selecting a priority maintenance task based on the sub-set of prior sensor logs, t and the correlated maintenance tasks; and outputting the priority maintenance task.

Security system and method

A method performed by one or more processors, and an apparatus is disclosed. The method may comprise identifying a request from a custom computer program within a sandbox to perform an operation not permitted within the sandbox, and receiving a first indication of security privileges associated with a provider of the custom computer program. The method may also comprise selectively causing the operation to be performed based on the first indication of security privileges.

Multiple Input Multiple Output, MIMO, baseband apparatus

A Multiple Input Multiple Output, MIMO, baseband apparatus comprising a baseband signal interface adapted to transmit or receive baseband signals comprising data mapped by a mapping unit of said baseband apparatus to a number, N, of MIMO layers which are coupled by a MIMO layer coupling unit of said baseband apparatus to different remote radio heads connected to said baseband apparatus. 1. A Multiple Input Multiple Output , MIMO , baseband apparatus comprising:a baseband signal interface adapted to transmit or receive baseband signals comprising data mapped by a mapping unit of said baseband apparatus to a number, N, of MIMO layers which are coupled by a MIMO layer coupling unit of said baseband apparatus to different remote radio heads connected to said baseband apparatus.2. The apparatus of claim 1 ,wherein each remote radio head comprises at least one antenna array with at least one antenna connected via a frontend transceiver to a digital processing unit of said remote radio head.3. The apparatus of claim 1 ,wherein the baseband apparatus comprises for each remote radio head connected to said baseband apparatus a CPRI interface connected via an optical link to a CPRI interface of said remote radio head.4. The apparatus of claim 1 , wherein the MIMO layer coupling unit is adapted to switch MIMO layers output by said mapping unit to said remote radio heads in response to a control signal output by a MIMO layer coupling control unit of said baseband apparatus.5. The apparatus of claim 1 , wherein said MIMO layer coupling control unit is adapted to generate the control signal applied to said MIMO layer coupling unit depending on downlink claim 1 , DL claim 1 , parameters and/or uplink claim 1 , UL claim 1 , parameters of at least one wireless link provided between the remote radio heads of said baseband apparatus and a mobile user equipment claim 1 , UE claim 1 , device.6. The apparatus of claim 1 , wherein the remote radio heads using a radio transmission ...

SPECIFIC SYNTHETIC CHIMERIC XENONUCLEIC ACID GUIDE RNA; s(XNA-gRNA) FOR ENHANCING CRISPR MEDIATED GENOME EDITING EFFICIENCY

The invention provides xenonucleic acids and synthetic chimeric xenonucleic acid guide RNA; s(XNA-gRNA) for enhancing crispr mediated genome editing efficiency. The invention also provides methods and compositions for inducing CRISPR/Cas-based gene editing/regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using single guide RNAs (sgRNAs) that have been chemically modified with xeno nucleic acids which enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a sgRNA that has been chemically modified with xeno nucleic acids to correct a mutation in a target gene associated with the genetic disease.

DNA MUTATION DETECTION EMPLOYING ENRICHMENT OF MUTANT POLYNUCLEOTIDE SEQUENCES AND MINIMALLY INVASIVE SAMPLING

The invention relates to a method for enriching a target polynucleotide sequence containing a genetic variation said method comprising: (a) providing two primers targeted to said target polynucleotide sequence; (b) providing a target specific xenonucleic acid clamp oligomer specific for a wildtype polynucleotide sequence; (c) generating multiple amplicons using PCR under specific temperature cycling conditions; and (d) detecting said amplicons. We introduce a novel molecule, Xenonucleic Acid (XNA) for the NGS library preparation. XNA is able to selectively suppress amplification of DNA with wild type alleles and amplify DNA containing mutant alleles. Mutants with low allelic frequency will be easily detectable without deep sequencing after enrichment by adding XNA in multiplex PCR. The 17 actionable mutants related to lung or colorectal cancer diseases at different variant allelic frequency (VAF)% were investigated. Clinical sensitivity is significantly improved with XNA in various types of samples.

Device for implanting compression plate within a body

A delivery device delivers a compression plate to a fracture line in a bone. The delivery device includes a body that retains the compression plate in a strained condition, the body including a proximal end, a distal end, and a first beam. The delivery device also includes a cover plate attached to and moveable relative to the body, the cover plate including a second beam. A space is defined between the first beam and the second beam that receives the compression plate. The delivery device also includes a compression clip that retains the compression plate in the space.

System and method for determining and indicating value of healthcare

A computer-implemented method analyzes a medical treatment plan for a patient having a medical condition and determines a value of health care of the plan. The method includes a processor executing instructions to enter the patient into an electronic medical records (EMR) system of a medical facility visited by the patient, assign the patient a diagnosis, recording the medical treatment plan, and generate a portal for accessing and displaying the medical treatment plan. The method further includes a health care value analytics (HVA) server accessing and using historical data, generating a value baseline for approved medical treatments of medical conditions addressed by the medical treatment plan, generating one or more HVA data objects that provide a running comparison of the medical treatment plan and the value baseline, and providing the HVA data objects for display through the portal onto an EMR/HVA access device.

Method and apparatus for dispersing a sample of particulate material

Knock-down vertical file

A knock-down file cabinet and in particular, a vertical file cabinet wherein both the cabinet housing and each of the drawers have a knock-down construction. The drawers use either separate components that are slidably fitted together, or a single sheet of material that defines the bottom, side and back walls. Each drawer construction is usable within the cabinet housing so as to define a complete knock-down vertical file cabinet which can be readily shipped in a relatively compact container or package and thereafter assembled together.

Knock-down vertical file

A knock-down file cabinet and in particular, a vertical file cabinet wherein both the cabinet housing and each of the drawers have a knock-down construction. The drawers use either separate components that are slidably fitted together, or a single sheet of material that defines the bottom, side and back walls. Each drawer construction is usable within the cabinet housing so as to define a complete knock-down vertical file cabinet which can be readily shipped in a relatively compact container or package and thereafter assembled together.

Soft prosthesis shell texturing method

A method of texturing a soft prosthetic implant shell, such as a silicone breast implant shell. A soft prosthetic implant with a textured external surface layer of silicone elastomer and having an open-cell structure is made by adhering and then dissolving round salt crystals. The resulting roughened surface has enhanced physical properties relative to surfaces formed with angular salt crystals. An implant having such a textured external surface layer is expected to help prevent capsular contraction, to help prevent scar formation, and to help in anchoring the implant within the body.

Multi-touch touchscreen incorporating pen tracking

The present invention relates to a multi-touch display system that supports both multi-touch human input as well as input from a digital pen. The display system has a display panel that is configured to allow human touches along a front surface to be detected and tracked. The display panel also includes a location pattern that preferably covers the viewable areas of the display panel. The location pattern is configured to allow any location within the location pattern to be detected by analyzing a portion of the display pattern that is associated with the particular location. The digital pen is used to “write” on the display panel, wherein such a writing function involves detecting the location where writing occurs and controlling display content that is displayed on the display panel to reflect what is being written.

Multi-touch touchscreen incorporating pen tracking

The present invention relates to a multi-touch display system that supports both multi-touch human input as well as input from a digital pen. The display system has a display panel that is configured to allow human touches along a front surface to be detected and tracked. The display panel also includes a location pattern that preferably covers the viewable areas of the display panel. The location pattern is configured to allow any location within the location pattern to be detected by analyzing a portion of the display pattern that is associated with the particular location. The digital pen is used to “write” on the display panel, wherein such a writing function involves detecting the location where writing occurs and controlling display content that is displayed on the display panel to reflect what is being written.

Multi-touch touchscreen incorporating pen tracking

The present invention relates to a multi-touch display system that supports both multi-touch human input as well as input from a digital pen. The display system has a display panel that is configured to allow human touches along a front surface to be detected and tracked. The display panel also includes a location pattern that preferably covers the viewable areas of the display panel. The location pattern is configured to allow any location within the location pattern to be detected by analyzing a portion of the display pattern that is associated with the particular location. The digital pen is used to “write” on the display panel, wherein such a writing function involves detecting the location where writing occurs and controlling display content that is displayed on the display panel to reflect what is being written.

Multi-touch tochscreen incorporating pen tracking

The present invention relates to a multi-touch display system that supports both multi-touch human input as well as input from a digital pen. The display system has a display panel that is configured to allow human touches along a front surface to be detected and tracked. The display panel also includes a location pattern that preferably covers the viewable areas of the display panel. The location pattern is configured to allow any location within the location pattern to be detected by analyzing a portion of the display pattern that is associated with the particular location. The digital pen is used to "write" on the display panel, wherein such a writing function involves detecting the location where writing occurs and controlling display content that is displayed on the display panel to reflect what is being written.

Multi-touch touchscreen incorporating pen tracking

Multi-touch touchscreen incorporating pen tracking

e The present invention relates to a multi-touch display system that supports both multi-touch human input as well as input from a digital pen. The display system has a display panel that is configured to allow human touches along a front surface to be detected and tracked. The display panel also includes a location pattern that preferably covers the viewable areas of the display panel. The location pattern is configured to allow any location within the location pattern to be detected by analyzing a portion of the display pattern that is associated with the particular location. The digital pen is used to "write" on the display panel, wherein such a writing function involves detecting the location where writing occurs and controlling display content that is displayed on the display panel to reflect what is being written.

Multi-touch touchscreen incorporating pen tracking

The present invention relates to a multi-touch display system that supports both multi-touch human input as well as input from a digital pen. The display system has a display panel that is configured to allow human touches along a front surface to be detected and tracked. The display panel also includes a location pattern that preferably covers the viewable areas of the display panel. The location pattern is configured to allow any location within the location pattern to be detected by analyzing a portion of the display pattern that is associated with the particular location. The digital pen is used to “write” on the display panel, wherein such a writing function involves detecting the location where writing occurs and controlling display content that is displayed on the display panel to reflect what is being written.

Multi-touch tochscreen incorporating pen tracking

Cushion inside a cushion patient interface

A patient interface device that includes a mask shell and a cushion assembly. The cushion assembly includes a seal cushion and a support cushion. The seal cushion contacts a first area of a patient's face to form a seal therewith. The support cushion defines a second area over a face of such a patient when the patient interface device is being worn. The second area overlaps at least a portion of the first area.

Surgical stapler with anvil sensor and lockout

A stapler is disclosed that includes a mechanism for sensing whether the stapler is loaded with replaceable anvil and for preventing the stapler from being closed or fired when the replaceable anvil is absent.

Ultrasound transesophageal probe for imaging and diagnosis by multiple area scanning

Wrapping materials for smoking articles

Smokable rods of cigarettes are manufactured using wrapping materials that incorporate at least one fibrous material (e.g., flax fibers, hardwood pulp fibers and/or softwood pulp fibers) at least one filler material (e.g., calcium carbonate in particulate form). The wrapping materials possess multi-layer coatings. The wrapping materials possess coatings in the form of series of spaced apart bands, each band possessing a series of layers. At least one of the coating layers can have a filler material dispersed or suspended within a film-forming material of that layer. For a representative wrapping material, a pattern of applied to the wire side major surface of the wrapping material substrate as a plurality of layers, and at least one of the layers includes ethylcellulose and calcium carbonate. For that layer, the calcium carbonate is present in an amount greater than the ethylcellulose, on a weight basis. The ethylcellulose and calcium carbonate typically are applied as part of a non-aqueous formulation incorporating iso-propyl acetate, triacetin and lecithin.

Operating turbine resonant blade monitor

An operating turbine monitor is described incorporating one or more acoustic sensors positioned next to a blade row of a rotor, an analog digital converter, a tachometer sensor at the rotor shaft, a memory, a synchronous averaging circuit, a subtractor circuit, and a comparator. The invention overcomes the problem of monitoring an operating tubine for order-related turbine blade vibration and for non order-related turbine blade vibration as well as for other turbine conditions.

Post-panel connector arrangement

An interior upright space-dividing wall system wherein portable upright panel assemblies are connected to one another through upright support posts, the latter having a foot for engagement with a floor. Each panel assembly includes a vertically elongate frame member which defines an upright end edge of the respective panel assembly and supports a panel connector member for joining the panel assembly to the support post. The panel connector members include upper and lower jaw members which engage in corresponding openings in a side wall of the support post. The support post includes a pair of connectors at a lower end thereof, each of which supports a lower end of one of the panel assemblies.

Carboxamide and sulfonamide derivatives useful as tead modulators

The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.

Compositions that include hemagglutinin, methods of making and methods of use thereof

Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the protein portion includes at least a portion of a globular head and at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and wherein the protein portion lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions can further include a Toll-like Receptor agonist and a carrier protein.

Heterobifunctional molecules as tead inhibitors

The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Electrode heating with remediation agent

A remediation method and system is disclosed. A plurality of conductors is installed into the subsurface to introduce electrical current to produce heat in the subsurface. One or more agents are released into the subsurface to cause or accelerate the decomposition of one or more pre-existing halogenated organic compounds and release halogen ions, improving electrode performance.

Seat

A seat which provides a seating position which is physiologically desirable and which has a seat member so arranged that a user is guided to sit with the thighs obtusely opened whereby the sacrum is caused to adopt a position such that it is properly wedged between the ilia and supported by the inward thrust of the ilia by the position of the legs.

Systems and methods for resin recovery in additive manufacturing

A method of producing multiple batches of objects by stereolithography, includes the steps of: (a) dispensing an initial or subsequent batch of dual cure resin into a stereolithography apparatus ( 11 ), the resin including a light polymerizable component and a heat polymerizable component; (b) producing an intermediate object by light polymerization of the resin in the apparatus ( 12 ), wherein the intermediate object retains excess resin on a surface thereof; then (c) separating excess resin from the intermediate object ( 13 ); (d) blending the excess resin with additional dual cure resin to produce a subsequent batch of dual cure resin ( 15 ); (e) repeating steps (a) through (c), and optionally repeating step (d), to produce additional object(s); and (f) baking the objects, together or separately, to produce multiple batches of objects ( 14 ).

Method and system for allocating specific appointment time windows in a service industry

The present invention provides a method for allocating appointment time windows. The steps of this method include creating a statistical estimate of a daily schedule comprising a series of estimated service orders. An actual service order is then received. This actual service order is inserted into the daily schedule by using a set of scheduling instructions for determining the least cost to employ the available service resources. At this point, this actual service order does not have a system imposed time window. The set of scheduling instructions is used to determine a time window surrounding this insertion point. If the customer accepts this time window, then the closest estimated service order is replaced by this actual service order, and the daily schedule is recomputed based upon the revised set of service orders to yield a revised daily schedule. This process may be repeated for any number of days or time periods from which the customer may choose the time window best meeting the customer's availability.

Systems and methods for managing notes

At least some aspects of the present disclosure feature systems and methods for managing notes. The note management system includes a note source, a note recognition module, a note extraction module, and a note labeling module. The note source is a visual representation of a scene having a note. The note recognition module is configured to receive the visual representation and determine a general boundary of the note from the visual representation. The note extraction module is configured to extract content of the note from the visual representation based on the determined general boundary. The note labeling module is configured to label the note with a category.

T cell regulation

Pressure sensitive recor system

Lock mechanism

A lock mechanism comprising a control element arranged for rotation about an axis between an active position and an inactive position, the control element including a control head having at least one axially extending projection, the lock mechanism further comprising a lock element that is axially aligned with the control element and includes a lock element head, the lock element head having at least one axially extending projection, the projection(s) of the control head and the projection(s) of the lock element head arranged such that in the active position, the lock element and control element ge held apart by the projections and in the inactive position, the projections can mesh together to permit axial movement of the lock element relative to the control element.

Processing sensor logs

A method of processing sensor logs is described. The method includes accessing a first sensor log and a corresponding first reference log. Each of the first sensor log and the first reference log includes a series of measured values of a parameter according to a first time series. The method also includes accessing a second sensor log and a corresponding second reference log. Each of the second sensor log and the second reference log includes a series of measured values of a parameter according to a second time series. The method also includes dynamically time warping the first reference log and/or and second reference log by a first transformation between the first time series and a common time-frame and/or a second transformation between the second time series and the common time-frame. The method also includes generating first and second warped sensor logs by applying the or each transformation to the corresponding ones of the first and second sensor logs.

Production of substrate for tensilely strained semiconductor

A process and method for producing strained and defect free semiconductor layers. In a preferred embodiment, silicon on insulator may be used as a substrate for the growth of fully relaxed SiGe buffer layers. A new strain relief mechanism operates, whereby the SiGe layer relaxes without the generation of threading dislocations within the SiGe layer. This is achieved by depositing SiGe on an SOI substrate with a superficial silicon thickness. Initially the strain in the SiGe layer becomes equalized with the thin Si layer by creating tensile strain in the Si layer. Then the strain created in the thin Si layer is relaxed by plastic deformation during an anneal. Since dislocations are formed, and glide in the thin Si layer, threading dislocations are not introduced into the upper SiGe material. A strained silicon layer for heterostructures may then be formed on the SiGe material.

Allergen absorbent and blocking gel

AN ALLERGEN ABSORBENT AND BLOCKING GEL ABSTRACT OF THE DISCLOSURE An allergen absorbent and blocking gel for topical application to the skin comprises an organophilic clay of the smectite type and a quaternary ammonium compound, having aryl or alkyl groups in the range of from 10 to 22 carbon atoms and a vehicle comprising long-chain hydrocarbon or volatile silicone. The material can be made in the form of a stick, a salve or an aerosol spray. It is essential that the organophilic clay gel be highly activated. This is accomplished by high-shear mixing and/or by the use of a low molecular weight polar organic dispersant, such as propylene carbonate. This can also be accomplished using self-activating and self-dispersing clays which do not require high shear or polar activators. Application of the resulting highly-activated gel to the skin results in a blocking effect by means of the clay platelets and an absorption and retention of the urushiol oil allergen in the active tallow tails of the alkyl groups of the quaternary ammonium compound which has been ion exchanged with the clay.

CATALYTIC ANTIBODY COMPONENT

Method for treating cancer with an antibody to CD223 protein

Mammals with cancer are treated with an antibody which specifically binds to CD223 protein and inhibits negative T cell regulatory function of CD223. The mammal may be a human. The antibody may be a monoclonal antibody. The amount of the antibody administered may be sufficient to enhance an immune T cell response to the cancer.

Direct to container system with on-line weight control and associated method

Carboxamide and sulfonamide derivatives useful as tead modulators

The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.

DEVICE FOR UNLOADING THRESHED MATERIALS DIRECTLY FROM THE ROTOR OF AN AXIAL FLOW COMBINE HARVESTER

Method for producing decorative sheet material

Control unit for use with a respiratory assist device

There is provided a control unit (100) for use with a respiratory assist device (102) that assists a subject (104) with respiration. The control unit (100) configured to detect a time at which delivery of an inhalable therapy to the subject (104) is manually triggered on an inhalable therapy device (106). The control unit (100) is also configured to detect whether the subject (104) has fallen asleep and, on detecting that the subject (104) has fallen asleep, control the inhalable therapy device (106) to automatically trigger delivery of the inhalable therapy to the subject (104) at least a predefined length of time following the detected time at which delivery of the inhalable therapy to the subject (104) is manually triggered.

Skin lightening composition

A topical composition comprising: (a) conjugated linoleic acid, and/or derivatives thereof comprising conjugated linoleic acid moieties, in which at least 1% by weight of the conjugated linoleic acid and/or moieties is present as the trans 10, cis 12 isomer, and (b) a dermatologically acceptable carrier. The product is particularly suitable for lightening human skin.

Lock mechanism

A lock mechanism comprising a control element arranged for rotation about an axis between an active position and an inactive position, the control element including a control head having at least one axially extending projection, the lock mechanism further comprising a lock element that is axially aligned with the control element and includes a lock element head, the lock element head having at least one axially extending projection, the projection(s) of the control head and the projection(s) of the lock element head arranged such that in the active position, the lock element and control element ge held apart by the projections and in the inactive position, the projections can mesh together to permit axial movement of the lock element relative to the control element.

Determining maintenance for a machine

Systems, methods, non-transitory computer readable media can be configured to accessing a target sensor log corresponding to a first machine; accessing one or more prior sensor logs corresponding to the first machine and one or more prior sensor logs corresponding to a plurality of second machines which are of the same type as the first machine; accessing a plurality of computer readable logs corresponding to the first machine and the second machines, the computer readable logs for each second machine comprising a maintenance log comprising a plurality of maintenance task objects, each maintenance task object comprising a time and a maintenance task type; determining a set of statistical metrics characterising a difference between the target sensor log and each prior sensor log; selecting a sub-set of the prior sensor logs in dependence upon the statistical metrics; analysing the maintenance logs to correlate each prior sensor log included in the subset to one or more correlated maintenance tasks; selecting a priority maintenance task based on the sub-set of prior sensor logs, t and the correlated maintenance tasks; and outputting the priority maintenance task.

Soft filled prosthesis shell with discrete fixation surfaces

Electrically controlled tripping mechanism

T cell regulation

Negative pressure wound dressing management system

A wound exudate management system includes a pump for generating negative pressure, a dressing for covering and protecting a wound of a user, a tube including an interior lumen, the tube disposed between the pump and the dressing such that the pump and the dressing are in fluid communication via the interior lumen. The dressing includes an adhesive layer for adhering the dressing adjacent the wound, a wound contact layer, a pressure dispersion layer, a plurality of layers of absorbent material disposed between the wound contact layer and the pressure dispersion layer, a backing layer having a first surface and a second surface, the first surface of the backing layer being adjacent, and in contact with, the pressure dispersion layer and the adhesive layer, and a flexible connector disposed on the second surface of the backing layer.

Therapeutic compounds

The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R 1 -R 3 have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.

Composite closure with enhanced sealing

A composite closure for a container having carbonated contents includes an outer closure cap having a top wall portion, and an annular depending skirt portion. A disc-shaped sealing liner is positioned within the closure cap adjacent the inside surface of the top wall portion. The liner includes an inwardly facing sealing portion at the periphery thereof, and further includes an annular seal bead which projects downwardly from the liner in a direction away from the top wall portion. The closure is configured for enhanced sealing with an associated container, with the top wall portion of the outer closure cap preferably including a relatively thick, peripheral reinforcing region which overlies the annular seal bead of the liner for further enhancing sealing.

Indexing system

Bottle holder

Asynchronous frac-to-frac operations for hydrocarbon recovery and valve systems

The present description relates to processes and systems for asynchronous frac-to-frac operations for recovering hydro-carbons. The processes can include the use of injection-only and production-only valves that include a housing and at least one sleeve as well as flow restriction components, check valves, or other features. The flow restriction component can be a tortuous path provided in the sleeve. The check valves can be integrated into the sleeve or into the housing of the valve. Various different types of valve assemblies can be used and integrated with flow restriction components and/or check valves.

Compositions and methods comprising dendrimers and therapeutic agents

Compositions of dendrimers conjugated with one or more therapeutic agents that decrease exosome secretion and methods of use thereof for treating, alleviating, and/or preventing one or more symptoms associated with one or more neurological disease or disorders, cancer, inflammatory diseases, bacterial and viral infections, and other disorders have been developed. Preferably, the therapeutic agents are one or more agents that inhibit or reduce activity and/or quantity of neutral sphingomyelinase 2 (nSMase2) such as small molecule inhibitors of nSMase2. Compositions are particularly suited for reducing Aβ plaque formation, reducing tau propagation, improving cognition, or combinations thereof in a subject with psychiatric and neurological disorders. Compositions are also suited for treating, alleviating, and/or preventing one or more symptoms associated with cancer, bacterial and viral infections, and inflammatory diseases. Methods of treating a human subject having one or more of the diseases and disorders are provided.

Control unit for use with a respiratory assist device

Data formats and usage for massive point to point route calculation

The invention is directed to a method by which optimal paths are found between one or more start destinations and one or more end destinations. First destination and travel data is converted into a node and edge data format, wherein the nodes represent start points and the edges have a weight related to a travel weight. These nodes and edges are subdivided into subsets. The paths between the start nodes and each of the end nodes are determined using the node and edge representations stored in the subsets. A selected union of subsets is determined that contains the start end destinations. The optimal paths are determined by using the travel values associated with the edges connecting the nodes. The union of subsets, which may comprise less than the full amount of subsets, is loaded for the path determination. Or, when the path determination perceives that a relevant boundary has been reached in a path determination, that next subset in the union of subsets is loaded. The newly loaded subset is “joined” to the already loaded subsets, thus allowing the completion of the path determination.

Rail-joint.

Adjustable headgear

An adjustable headgear assembly ( 10 ) for securing a respiratory interface device ( 26 ) to the head of a patient that includes a headgear member ( 12 ) that fits over the crown and back portion of a human head. The headgear member ( 12 ) has upper side portions ( 14 ) positionable above and forward of the ears of a human head and lower side portions ( 16 ) positionable below the ears and along the back portion of the head. A pair of upper retention members ( 20 ) are provided. Each pair of upper retention members ( 20 ) extends downwardly and forwardly from the upper side portions ( 14 ). A pair of lower retention members ( 30 ) extend forwardly and upwardly from each of the side portions. Each pair of upper ( 20 ) and lower ( 30 ) retention members are structured to engage a respiratory interface device ( 26 ).

Health status system, platform, and method

A health status platform includes a receiving component that receives a test result a test of a biological sample collected from a human patient. The test result includes an indication of a presence of an infectious disease in the patient, and an identification and a verification of the patient. The platform includes a certificate component that issues a certificate of origin of the biological sample; and a data merging component that cooperates with a venue access manager that controls access to a venue. The data merging component implements a distributed ledger system that stores encrypted test results of the patient and the identification and verification of the patient, and an end-to-end encryption system that receives an encrypted venue access request from a venue access manager, decrypts the access request, determines if an access request is valid, and if valid, provides an encrypted certificate of origin to the venue access manager.

Detent mechanism

INHIBITORS OF CATALYTIC ANTIBODIES

Intravascular device and carrier tube with interference fit member

An intravascular device can have an elongate shaft and a proximal hub assembly. The proximal hub assembly can include an interference fit member (IFM) which forms an interference fit with a carrier tube to reduce the tendency of the device to fall out of the carrier tube during handling and to provide for easy removal of the device when ready for use.

Improvements in Pivoted Jaw Tools.

15,758. Powell, G. H. July 6. Nut-crackers.-In pivoted jaw tools, such as nut crackers, of the type having a fixed jaw and handle, a pivoted jaw with a rear extension, and a pivoted handle connected to the pivoted jaw by a link, the rearward extension 10 is located between the handles 6, 7. A spring 15 normally holds the jaws open.

Internal beam plates and associated instrumentation for performing surgical methods

Internal beam plates and associated instrumentation may be utilized for performing arthrodesis procedures, bone fracture procedures, osteotomy procedures, etc. Exemplary surgical methods that may be performed using the internal beam plates and associated instrumentation include, but are not limited to, lapidus bunionectomy procedures, metatarsophalangeal (MTP) procedures, chevron procedures, fracture repair procedures, etc. The exemplary internal beam plates incorporate an integral beam that is configured to increase strength and stiffness across a fusion site. The exemplary cutting/prep guides are configured to allow surgeons to reduce, prepare, and cut bones for receiving the beam of the internal beam plate using one or more guides.

Electrically controllable valve

Anti-cancer vaccine composition comprising an anti-CD223 antibody and kit comprising an anti-cancer vaccine and an anti-CD223 antibody

Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.

Devices for bleeding reduction and methods of making and using the same

In some embodiments, a system includes an applicator pad, an application device (e.g., a grip), and a reservoir. The grip can be releasably couplable to the applicator pad and configured to dispose the applicator pad against a wound of a subject such that pressure can be transferred to the wound via the applicator pad to enhance hemostasis. The reservoir can be configured to contain medication to be released to the wound via the applicator pad.

In situ injection or production via a well using dart-actuated valve assemblies and related system and method

An actuation dart for deployment down a tubing string installed within a wellbore and provided with one or more valve assemblies is provided. The actuation dart includes a dart body adapted to be carried down the tubing string to the valve assembly via fluid flow. The dart body has a shifting head provided at a first end of the dart body, the shifting head being configured to engage and shift the valve assembly in the open configuration to enable fluid injection in a reservoir surrounding the wellbore. A method for hydrocarbon recovery from a wellbore using the actuation dart is also provided, along with a wellbore system adapted to receive the actuation dart.

SWING FINGER ACTUATOR AND METHOD FOR ACTIVE FLOW CONTROL.

Un actuador para desplazar un fluido para alterar características del flujo cerca de una superficie aerodinámica (24), que comprende: medios para desplazar (16) el fluido; medios para envolver al menos parcialmente (18) los medios para desplazar (16), comprendiendo los medios envolventes (18) una cámara que tiene un segundo lado y un primer lado; estando los medios para desplazar dispuestos para desplazarse en vaivén dentro de la cámara; y primeros medios para acceder (20) al primer lado de los medios envolventes, en los que los primeros medios para acceder están adaptados a estar situados en la superficie aerodinámica y a estar en comunicación fluida con una corriente de fluido (32) que pasa sobre la superficie aerodinámica, en los que el fluido es expelido desde los primeros medios para acceder (20) cuando los medios para desplazar (16) se desplazan hacia el primer lado de los medios envolventes, y el fluido es impulsado hacia dentro de los primeros medios para acceder cuando los medios para desplazar se desplazan hacia el segundo lado de los medios envolventes. An actuator for displacing a fluid to alter flow characteristics near an aerodynamic surface (24), comprising: means for displacing (16) the fluid; means for at least partially wrapping (18) the means for moving (16), the enveloping means (18) comprising a chamber having a second side and a first side; the means for moving being arranged to move in a reciprocating manner within the chamber; and first means for accessing (20) the first side of the enveloping means, in which the first means for accessing are adapted to be located on the aerodynamic surface and to be in fluid communication with a fluid stream (32) passing over the aerodynamic surface, in which the fluid is expelled from the first means to access (20) when the means for moving (16) are moved towards the first side of the enveloping means, and the fluid is propelled into the first means for access when the means to move move to the second side ...

Low component count release mechanism

An electrically controlled actuator comprises at least two co-planar blades formed by a U-shaped pressing from a sheet of material. The end of one blade ( 60 ) is used as a mounting for the actuator and the end of the other blade ( 85 ) is used as an actuation surface. Piezo ceramic material is fixed to opposite surface of the two blades in order to flex the actuation surface with respect to the fixed surface. An electrically relay or residual current device incorporating such an actuator is disclosed.

Adjustable headgear

An adjustable headgear assembly (10) for securing a respiratory interface device (26) to the head of a patient that includes a headgear member (12) that fits over the crown and back portion of a human head. The headgear member (12) has upper side portions (14) positionable above and forward of the ears of a human head and lower side portions (16) positionable below the ears and along the back portion of the head. A pair of upper retention members (20) are provided. Each pair of upper retention members (20) extends downwardly and forwardly from the upper side portions (14). A pair of lower retention members (30) extend forwardly and upwardly from each of the side portions. Each pair of upper (20) and lower (30) retention members are structured to engage a respiratory interface device (26).

Wrapping materials for smoking articles

A wrapping material for a smoking article is proposed, the wrapping material comprising a base sheet having a major surface, and a plurality of bands applied to the major surface in the form of a pattern, each band comprising a plurality of layers applied one over the other, wherein at least one of the plurality of layers incorporates as an additive at least one flavoring agent, and at least one of the plurality of layers incorporates as an additive a hydrate material.

Implosion-resistant cathode-ray tube

Exhaust arrangement for patient interface device and patient interface including same

An arrangement (26) for exhausting gases from a cavity (20) of a patient interface (12) to an ambient environment, and a patient interface for use in providing a flow of treatment gas to the airway of a patient comprising such arrangement. The arrangement includes a body member (28) that forms a portion of the patient interface between the cavity and the ambient environment. The body member includes: - a number of inlets (30) defined in a first side of the body member for receiving gases from the cavity; - a number of outlets (32) defined in a second side of the body member opposite the first side for provide for the exit of gases from the patient interface to the surrounding environment; and - a number of high-drag passages (34) defined in the body member extending laterally between an inlet of the number of inlets and an outlet of the number of outlets.

Compositions that include hemagglutinin, methods of making and methods of use thereof

Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the portion includes at least a portion of a globular head, includes at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions comprise a flagellin component or a Toll-like Receptor agonist component that is at least a portion of a flagellin or a Toll-like Receptor agonist, wherein the flagellin component or Toll-like Receptor agonist component includes at least one cysteine residue and whereby the flagellin component or Toll-like Receptor agonist component activates a Toll-like Receptor 5 or Toll-like Receptor. Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein at least one lysine of the flagellin component has been substituted with at least one arginine, serine and histidine, whereby the flagellin component activates Toll-like Receptor 5. Compositions can further include an antigen, such as an influenza antigen, a flavivirus antigen, a pathogen-related antigen, a bacterial capsular antigen and a carrier protein. The compositions are used to stimulate an immune response and a protective immune response in a subject.