01-08-2013 дата публикации
Номер: US20130197662A1
The invention discloses a process for fabricating a biomaterial, comprising: a) joining a porous collagen based-material with a non-porous collagen based-material by applying a controlled amount of a bonding layer of a gel comprising collagen to a bonding surface of the non-porous collagen based-material, and contacting a surface of the porous collagen based-material with the gel applied to the bonding surface to partially hydrate a section of the porous material at the interface between the materials; b) drying the gel to dry to bond the materials together; and c) cross-linking the collagens in the bonding layer. Also disclosed are biomaterials and implants produced using the fabrication process. 1. A process for fabricating a biomaterial , comprisinga) joining a porous collagen based-material with a non-porous collagen based-material by applying a controlled amount of a bonding layer of a gel comprising collagen to a bonding surface of the non-porous collagen based-material, and contacting a surface of the porous collagen based-material with the gel applied to the bonding surface to partially hydrate a section of the porous material at the interface between the materials;b) drying the gel to dry to bond the materials together; andc) cross-linking the collagens in the bonding layer.2. The process of wherein in drying step (b) the structure/shape of the materials is substantially retained without distortion.3. The process as claimed in wherein step (b) comprises air drying.45-. (canceled)6. The process as claimed in characterised in that the gel is acidic or alkaline prior to being applied to the bonding surface.7. The process as claimed in wherein the gel gelates at neutral pH.89-. (canceled)10. The process as claimed in wherein the gel further comprises a glycosaminoglycan selected from the group consisting of: chondroitin 4-sulfate claim 1 , chondroitin 6-sulfate claim 1 , keratan sulfate claim 1 , dermatan sulfate claim 1 , heparan sulfate claim 1 , and ...
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