16-05-2013 дата публикации
Номер: US20130123249A1
Принадлежит:
Novel benzoxazine oxazolidinone compounds, preparation methods and uses thereof are disclosed, which belong to the field of pharmacy. More specifically, novel benzoxazine oxazolidinone compounds represented by the following general formula (I), preparation methods and uses thereof in preparing medicament for treating infectious diseases, especially infectious diseases caused by multi-drug resistant bacteria, are disclosed. 112-. (canceled)14. Benzoxazine oxazolidinone compounds represented by the general formula (I) claim 13 , optical isomers or pharmaceutically acceptable salts thereof according to claim 13 , wherein said five membered or six membered aromatic or non-aromatic heterocyclic group comprises 1 to 2 N atoms;{'sub': 2', '2', '3', '2', '3', '3', '3', '3', '4', '3', '3', '4', '1', '3, 'Said five membered or six membered aromatic or non-aromatic heterocyclic group may optionally be substituted by the following functional groups: F, Cl, Br, —OH, —NO, —CHO, —CN, —NH, —CF, —C≡CH, —C≡CCHOH, —COOH, —OR, —NHCOR, —COR; —CONRR, and —COOR, wherein each of Rand Rcan independently be C-Calkyl;'}{'sub': 1', '6', '3', '6', '1', '6', '3', '6', '2, 'or said five membered or six membered aromatic or non-aromatic heterocyclic group may optionally be substituted by C-Cstraight chain or branched chain alkyl group, or C-Ccycloalkyl group, and said C-Cstraight chain or branched chain alkyl group or C-Ccycloalkyl group may optionally be substituted by —OH, —CN, or —NH;'}{'sub': 1', '3, 'or said five membered or six membered aromatic or non-aromatic heterocyclic group may optionally be substituted by five membered or six membered aromatic or non-aromatic heterocyclic group, which contains at least one heteroatom selected from N and O and is either unsubstituted or substituted by C-Calkyl or oxygen.'}15. Benzoxazine oxazolidinone compounds represented by the general formula (I) claim 13 , optical isomers or pharmaceutically acceptable salts thereof according to claim 13 , wherein ...
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