Improved concentrated intravascular injection and infusion solutions

Use of amide complex compounds

Use of amide complex compounds

ABSTRACT OF THE DISCLOSURE ---------------Complex compounds of general Formula I (I) wherein n means the number 0, 1 or 2, R1 and R2 are independently hydrogen atoms, lower alkyl groups, phenyl groups, benzyl groups or, if n is the number 0, also jointly a trimethylene or a tetramethylene group, R3 is a saturated, unsaturated, straight-chain or branched-chain or cyclic aliphatic hydrocarbon residue of up to 16 carbon atoms or, if R4 is a hydrogen atom, a cycloalkyl group or an aryl or aralkyl group optionally substituted by one or several di-C1-C6-alkylamino groups or by one or several C1-C6-alkoxy groups, R4 is a hydrogen atom, a saturated, unsaturated, straight-chain or branched-chain or cyclic hydrocarbon residue of up to 16 carbon atoms, or R3 and R4 jointly mean a saturated or unsaturated 5- or 6-member ring which is optionally substituted by one or several C1-C6-alkyl, C1-C5-hydroxyalkyl residues, an optionally hydroxylated or Cl-C6-alkoxylated C2-C6-acyl residue, a hydroxy residue, a carbamoyl residue, a carbamoyl-substituted Cl-C6-alkyl residue, a carbamoyl residue substituted on the carbamoyl nitrogen by one or two Cl-C6-alkyl residue(s) -- which can also form a ring containing, if desired, an oxygen atom -- or a C1-C6-acylamino or C1-C6-alkylamino residue, this 5- or 6-membered ring optionally containing a further nitrogen, oxygen or sulfur atom, or a carbonyl group, X is a hydrogen atom and/or a metal ion equivalent of at least one element of atomic numbers 21-29, 42, 44 or 58-70, Y is a COOX- or group, with the proviso that at least two of the substitu-ents X stand for a metal ion equivalent, as well as their salts with organic and/or inorganic bases, are valuabe compounds for the organ-specific NMR diagnostics and in case of patients with renal insufficiency. .1.

Dtpa derivatives substituted in a novel way, their metal complexes, pharmaceutical agents that contain these complexes and their use in diagnosis and therapy

The invention concerns novel diethylenetriamine pentaacetic acid (DTPA) derivatives, their complexes and complex salts, containing an element of the atomic numbers 20 - 32, 39 - 51 or 57 - 83. The invention further concerns pharmaceutical compositions containing these compounds, their preparation and their use as contrast media and antidotes.

Cascade polymer bound complexing compounds their complexes and conjugates, processes for their production, and pharmaceutical agents containing them

Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.

Complexe builders bonded to sterwise prepared polymers, their complexes and conjugates, process for their preparation and pharmaceutical agents containing the same

Cascade polymers containing complexing ligands, if desired at least five ions of an element having an atomic number of from 21 to 29, 39, 42, 44 or 57 to 83, and if desired cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing agents and complexes for diagnostics and therapy.

1,4,7,10-TETRA-AZACYKLODODEKAN-BUTYLTRIOLER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA INNEHAOLLANDE PHARMACEUTICAL AEMNEN.

Use of amide complex compounds

Cascade polymers with iodine aromatic compounds

Iodine-containing dendrimeric polymers of general formula I A-(X)b ~~~(I), in which A stands for a nitrogen-containing nucleus of basic multiplicity b, whereby b stands for numbers 1 to 8 and X stands for a radical that consists of (see fig II) reproduction units S and at most 2" imaging radicals Z, in which n determines the number of generations and stands for numbers 1 to 10, S and Z have various meanings, are valuable x-ray diagnostic agents.

DTPA MONOAMIDES, PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF

Compounds of the general formula I <IMAGE> in which Z<1> and Z<2> in each case represent a hydrogen atom or the radical -(CH2)m-(C6H4)q-(O)k-(CH2)n-(C6H4)<SB >l-(O)r-R, in which m and n denote the figures 0-20, k, l, q and r denote the figures 0 and 1 and R denotes a hydrogen atom, an optionally OR<1>-substituted C1-C6-alkyl radical or a CH2COOR<1> group where R<1> denotes a hydrogen atom, a C1-C6-alkyl radical or a benzyl group, R<2> represents a saturated, unsaturated, straight- or branched-chain or cyclic alkyl group having up to 20 C atoms, aryl group or aralkyl group substituted by a carboxyl group optionally esterified with a C1-C6-alkyl or benzyl radical, or by a sulphone group, R<3> represents a hydrogen atom or a saturated, unsaturated, straight- or branched-chain or cyclic alkyl group having up to 20 C atoms, aryl group or aralkyl group optionally substituted by a carboxyl group which is optionally esterified with a C1-C6-alkyl or benzyl radical, or by a sulphone group, X represents a hydrogen atom and/or a metal ion equivalent of an element of atomic number 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, with the proviso that at least one of the substituents Z<1> and Z<2> represents a hydrogen atom, that - when n and l each represent the figure 0 - k and r do not simultaneously each denote the figure 1 and that, if desired, the radical of the acid groups is present as an ester or amide, and their salts with inorganic and/or organic bases, amino acids or amino acid amides, are useful pharmaceutical agents.y

Application of metal complexes as diagnostic agents for x-raying liver and bile ducts in computer tomography

Use of metal complexes as liver and gall bladder radiodiagnosis agents in computer tomography

Cascade polymers with iodine aromatic compounds

DTPA-complexes derivatives, pharmaceutical compositions containing them, their use and process for their preparation

Compounds of the general formula <IMAGE> in which Z<1> and Z<2> each represent a hydrogen atom or the radical -(CH2)m-(C6H4)q-(O)k-(CH2)n(C6H4) l-(O)r-R, in which m and n denote the figures 0 - 20, k, l, q and r denote the figures 0 and 1 and R denotes a hydrogen atom, an unsubstituted or OR<1>-substituted C1-C6-alkyl radical or a CH2COOR<1> group where R<1> denotes a hydrogen atom, a C1-C6-alkyl radical or a benzyl group, X represents a hydrogen atom and/or a metal ion equivalent of an element of atomic number 21 - 29, 42, 44 or 57 - 83, with the proviso that at least two of the substituents X represent a metal ion equivalent in which one of the substituents Z<1> and Z<2> represents a hydrogen atom and the other does not represent a hydrogen atom, in which - if n and l each represent the figure 0 - k and r do not simultaneously each denote the figure 1, in which Z<1> or Z<2> do not represent -CH2-C6H4-O-CH2-COOCH2C6H5 or CH2-C6H4-O-(CH2)5-COOCH2C6H5 and in which -(O)r-R does not represent -OH, and their salts with inorganic and/or organic bases, amino acids or amino acid amides, are useful pharmaceutical agents.

Metal complexes, suitable for use in diagnosis and therapy

The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and antidotes and process for their production.

Novelly substituted dtpa derivatives, metal complexes thereof, pharmaceuticals containing these complexes, diagnostic and therapeutic uses thereof and methods for preparing the complexes and pharmaceuticals

DTPA monoamides, pharmaceutical compositions containing these compounds, their use and processes for their preparation.

Compounds of the general formula I <IMAGE> in which Z<1> and Z<2> in each case represent a hydrogen atom or the radical -(CH2)m-(C6H4)q-(O)k-(CH2)n-(C6H4)<SB >l-(O)r-R, in which m and n denote the figures 0-20, k, l, q and r denote the figures 0 and 1 and R denotes a hydrogen atom, an optionally OR<1>-substituted C1-C6-alkyl radical or a CH2COOR<1> group where R<1> denotes a hydrogen atom, a C1-C6-alkyl radical or a benzyl group, R<2> represents a saturated, unsaturated, straight- or branched-chain or cyclic alkyl group having up to 20 C atoms, aryl group or aralkyl group substituted by a carboxyl group optionally esterified with a C1-C6-alkyl or benzyl radical, or by a sulphone group, R<3> represents a hydrogen atom or a saturated, unsaturated, straight- or branched-chain or cyclic alkyl group having up to 20 C atoms, aryl group or aralkyl group optionally substituted by a carboxyl group which is optionally esterified with a C1-C6-alkyl or benzyl radical, or by a sulphone group, X represents a hydrogen atom and/or a metal ion equivalent of an element of atomic number 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, with the proviso that at least one of the substituents Z<1> and Z<2> represents a hydrogen atom, that - when n and l each represent the figure 0 - k and r do not simultaneously each denote the figure 1 and that, if desired, the radical of the acid groups is present as an ester or amide, and their salts with inorganic and/or organic bases, amino acids or amino acid amides, are useful pharmaceutical agents.y

Enhanced concentrated injection and infusion solutions for intravasal application

Improved concentrated injection and infusion solutions for intravenous administration

Additives to concentrated injection and infusion solutions that avoid or mitigate acute or delayed hypersensitivity reactions as well as injection and infusion solutions that contain these additives are described.

Cascade polymers containing complex-forming ligands and their use as nmr and x-ray contrast agents

Derivatized DPTA complexes and their use in NMR and X-ray diagnostics

Use of metal complexes as liver and gall bladder x-ray diagnostic agentsin computer tomography

Metal complexes consisting of a metal of atomic number 39-42, 44-51 or 56-83, and a complexing agent are used to produce X-ray contrast media for use in enhanced-contrast computed tomography of the liver and the bile ducts.

Diagnostic 1,4,7,10-tetraazacyclododecane butyltriols, their use as diagnostic agents and process for their preparation

New multisubstituted DTPA derivatives and their metal complexes, pharmaceutical compositions containing such complexes, their use in diagnostics and therapy, presented primarily by the complexing agents and complexes, as well as by pharmaceutical compositions.

Dtpa monoamides, pharmaceutical agents containing these compounds, their use and process for their production

Abstract Compounds of general formula I (I) in which Z1 and Z2 each stand for a hydrogen atom or the radical

INNOVATIVELY SUBSTITUTED DTPA DERIVATIVES, THEIR METAL COMPLEXES, PHARMACEUTICAL AGENTS CONTAINING THESE COMPLEXES, THEIR USE IN DIAGNOSTICS AND THERAPY, AND METHOD FOR THE PRODUCTION OF THE COMPLEXES AND AGENTS

10-trihydroxybutyl-1,4,

1,4,7,10-Tetraazacyclododecane-butyltriols of the general formula IA <IMAGE> in which R<1> independently of one another denotes hydrogen or a metal ion equivalent and R<2> denotes a butyltriol radical, and their salts with organic or inorganic bases or amino acids are useful pharmaceutical agents.

ANVAENDNING AV AMIDKOMPLEXFOERENINGAR.

Dimer dtpa derivatives and their metal complexes, pharmaceuticals containing the same, their use in diagnosis and therapy and process for preparing said complexes and pharmaceuticals

Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production and pharmaceutical agents containing them

Cascade polymers containing complexing ligands, if desired at least five ions of an element having an atomic number of from 21 to 29, 39, 42, 44 or 57 to 83, and if desired cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing agents and complexes for diagnostics and therapy.

Haloaryl-substituted metal complexes pharmaceutical agents containing these complexes, their use in diagnosis, as well as process for the production of the complexes and agents

Dimeric DTPA derivatives, their metal complexes and pharmaceutical agents containing these complexes

The invention relates to new dimeric DTPA derivatives, their metal complexes, containing at least one ion of an element of atomic numbers 21-32, 37-39, 42-51 and 57-83, agents containing these complexes, their use in NMR diagnosis and/or diagnostic radiology, radiodiagnosis and radiotherapy, as well as process for their production.

Cascade polymer bound chelating compounds, their chelates and conjugates, processes for their production, and pharmaceutical agents containing them

Cascade polymers containing complexing ligands, if desired at least five ions of an element having an atomic number of from 21 to 29, 39, 42, 44 or 57 to 83, and if desired cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing agents and complexes for diagnostics and therapy.

KASKADPOLYMERBUNDNA KOMPLEXBILDARE, KOMPLEX OCH KJJJAT DAERAV, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH PHARMACEUTISKA PREPARAT INNEHAOLLANDE DEM.

Liposomes that contain contrast media for the visualization of intravascular space

The invention relates to liposomal contrast medium preparations for diagnostic visualization of intravascular space as well as their use in imaging diagnosis.

CASE POLYMER-BONDED COMPLEX FORMERS, COMPLEXES AND CONJUGATES THEREOF, PROCEDURE FOR THE PREPARATION OF THESE, SAME PHARMACEUTICAL AGENTS CONTAINING THESE.

Derivatized DTPA complexes, pharmaceutical compositions containing these compounds, their use and methods for their preparation

Compounds of the general formula <IMAGE> in which Z<1> and Z<2> each represent a hydrogen atom or the radical -(CH2)m-(C6H4)q-(O)k-(CH2)n(C6H4) l-(O)r-R, in which m and n denote the figures 0 - 20, k, l, q and r denote the figures 0 and 1 and R denotes a hydrogen atom, an unsubstituted or OR<1>-substituted C1-C6-alkyl radical or a CH2COOR<1> group where R<1> denotes a hydrogen atom, a C1-C6-alkyl radical or a benzyl group, X represents a hydrogen atom and/or a metal ion equivalent of an element of atomic number 21 - 29, 42, 44 or 57 - 83, with the proviso that at least two of the substituents X represent a metal ion equivalent in which one of the substituents Z<1> and Z<2> represents a hydrogen atom and the other does not represent a hydrogen atom, in which - if n and l each represent the figure 0 - k and r do not simultaneously each denote the figure 1, in which Z<1> or Z<2> do not represent -CH2-C6H4-O-CH2-COOCH2C6H5 or CH2-C6H4-O-(CH2)5-COOCH2C6H5 and in which -(O)r-R does not represent -OH, and their salts with inorganic and/or organic bases, amino acids or amino acid amides, are useful pharmaceutical agents.

Macrocyclic polymer complexing agents, their complexes, process for their production and pharmaceutical agents containing these compounds

Abstract of the Disclosure Polymeric compounds of general formula I . (M)nA (I), in which M stands for the radical of a macrocyclic complexing agent, A stands for a backbone molecule, which shows a deficit of n amino groups, n hydroxy groups or n carboxy groups, n stands for the numbers 1 to 400, characterized in that M, independent of one another, stands for complexing agents of general formula IA

Neuartig substituierte dtpa-derivate, deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel, deren verwendung in der diagnostik und therapie, sowie verfahren zur herstellung der komplexe und mittel

Verbesserte kontrastmittenlösungen für die intravasale anwendung

Novel, multiply, substituted dtpa derivatives and their metal complexes, pharmaceutical agents that contain these complexes, their use in diagnosis and therapy, as well as process for the production of pharmaceutical agents

Dtpa derivatives substituted in a novel way, their metal complexes, pharmaceutical agents that contain these complexes and their use in diagnosis and therapy

Kaskadenpolymere mit iodaromaten

Makrocykliske polymer-kompleksdannere, deres komplekser, fremgangsmaater for fremstilling av disse, og farmasoeytiskemidler inneholdende disse

Macrocyclic polymer complexing agents,their complexes,process for their production and pharmaceutical agents containing these compounds

Macrocyclic polymer complexing agents, their complexes,¹process for their production and pharmaceutical agents¹containing these compounds

Polymeric compounds of the general formula I (M)nA (I), in which M is the residue of a macrocyclic complexing agent, A is a backbone molecule which has a deficit of n amino, n hydroxyl or n carboxyl groups, n is the numbers 1 to 400, characterised in that M is, independently of one another, complexing agents of the general formula IA

Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Dimere dtpa-derivate und deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel, deren verwendung in der diagnostik und therapie sowie verfahren zur herstellung der komplexe und mittel

Use of metal complexes as x-ray diagnostic agents for the liver and gallbladder

1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel.

Macrocyclic polymer complexing agents, their complexes, process for their production and pharmaceutical agents containing these compounds

Polymeric compounds of the general formula I (M)nA (I), in which M is the residue of a macrocyclic complexing agent, A is a backbone molecule which has a deficit of n amino, n hydroxyl or n carboxyl groups, n is the numbers 1 to 400, characterised in that M is, independently of one another, complexing agents of the general formula IA <IMAGE>

Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel.

Kontrastmiddelholdige liposomer for avbildning av det intravaskulære rom

Liposomale kontrastmiddel- preparater for diagnostisk avbildning av intravasalrommet, så vel som deres anvendelse i den bildedannende diagno- stikk.