Bed Bug Monitor Device for Vertical Surfaces

A bed bug monitor and/or capture device includes a housing defining a substantially enclosed interior space and a deadfall trap; a harborage element mounted adjacent the deadfall trap that defines at least one pathway through which bed bugs can travel; at least one bed bug attractant element positioned within the interior space of the housing; and at least one opening defined in at least one wall of the housing at a location either on or adjacent the deadfall trap and/or the harborage element, wherein fumes emanating from the bed bug attractant element can escape through the at least one opening to a location outside of the device in order to lure bed bugs toward the deadfall trap and the harborage element.

EFFERVESCENT COMPOSITION FOR IMPROVED CARBON DIOXIDE GENERATION IN INSECT MONITOR DEVICES

The present invention relates to a chemical composition and method of generating carbon dioxide for use with an insect monitor and/or capture device comprising: 1. A chemical composition for generating carbon dioxide for use with an insect monitor and/or capture device comprising:i) an effervescent agent,ii) a solid acid;iii) a deliquescent agent, and optionallyiv) an anti-clumping agent.2. The composition of claim 1 , wherein the effervescent agent comprises sodium bicarbonate.3. The composition of claim 1 , wherein the solid acid comprises citric acid monohydrate.4. The composition of claim 1 , wherein the anti-clumping agent comprises a material selected from the group consisting of fumed silica claim 1 , amorphous silica claim 1 , kaolin clay and mixtures thereof.5. The composition of claim 1 , wherein the deliquescent agent comprises magnesium chloride hexahydrate.6. The composition of claim 1 , wherein the molar ratio of the effervescent agent to solid acid to deliquescent agent is from 159:52:1 to 10:3:1.7. The composition of claim 1 , wherein the molar ratio of the effervescent agent to solid acid to deliquescent agent is from 40:13:1 to 20:6.5:1.8. A chemical composition for generating carbon dioxide for use with an insect monitor and/or capture device comprising:i) sodium bicarbonate,ii) citric acid monohydrate;iii) magnesium chloride hexahydrate, and optionallyiii) an anti-clumping agent.9. The composition of claim 9 , wherein the molar ratio of sodium bicarbonate to citric acid monohydrate to magnesium chloride hexahydrate is from 40:13:1 to 20:6.5:1.10. A method of generating carbon dioxide for use with an insect monitor and/or capture device comprising the steps of combining:i) an effervescent agent;ii) a solid acid;iii) a deliquescent agent; and optionally iv) an anti-clumping agent;in the presence of at least 11% relative humidity.11. The method of claim 10 , wherein the effervescent agent comprises sodium bicarbonate.12. The method of claim 10 , ...

Processes relating to the alkylation of pyrazoles

The present invention relates to processes for the preparation of a compound of formula (I) comprising reacting a compound of formula (IV) with a compound of formula III or (IIIA) in the presence of an acid; wherein R 1 is C 1 -C 4 haloalkyl; R 2 is optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R 3 is methyl or ethyl; R 4 is hydrogen, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; and n is 0 or 1.

MODEL-DRIVEN EVENT DETECTION, IMPLICATION, AND REPORTING SYSTEM

An event analysis system monitors information available from both publicly and privately distributed networks of information for events that are relevant to the user's particular business concerns. Those concerns are defined in a customized model of the user's organization and external business environment. The system receives the information, detects events in the information, interprets the events, and determines implications of these events. The detection and implication proceeds with regard to specific entities, relationships between entities, and definitions of the types of events which may occur in the environment in which the entities exist. Accordingly, the analysis system intelligently adapts its processing to recognize and report events which may be of interest for any particular entity. 1. An event analysis system comprising:an information database; an event model comprising an event type and event attributes of the event type;', 'an event detection engine;', 'an event implication engine;', 'an environment model comprising a first model entity and a focus entity, and a focus relationship from the focus entity to the first model entity; and, 'a memory comprising initiate execution of the event detection engine on articles to detect an event involving the first model entity represented in the articles and apply the event model to generate an event object according to a common event structure;', recognize that the focus relationship exists between the focus entity and the first model entity;', 'determine an inferred event on behalf of the focus entity in view of the focus relationship responsive to the detection of the event involving the first model entity; and, 'initiate execution of the event implication engine on the event object to], 'a processor coupled to the memory which is operable tocreate a new event object from the inferred event.2. The event analysis system of claim 1 ,the environment model further comprising fill entities and a fill ...

BLENDS OF POLYETHERIMIDE SULFONE AND POLY(ARYLENE SULFIDE)

Disclosed herein is a composition comprising a compatible blend of i) 60 to 85 weight percent of a linear poly(arylene sulfide), ii) 15 to 40 weight percent of a polyetherimide sulfone; and iii) 1 to 3 weight percent of a novolac resin having an average of 2 or more epoxy groups per molecule. Weight percent is based on the total weight of the composition. An article made from the composition has a tensile strength greater than or equal to 70 megaPascals (MPa), as determined by ASTM D638, an impact strength of greater than or equal to 3 kiloJoules per square meter (kJ/m), as determined by ASTM D256, and an elongation at break greater than or equal to 3% as determined by ASTM D638. Methods of making the composition are also disclosed. 1. A composition comprising a compatible blend of i) 60 to 85 weight percent of a linear poly (arylene sulfide) , ii) 15 to 40 weight percent of a polyetherimide sulfone; and iii) 1 to 3 weight percent of a novolac resin having an average of 2 or more epoxy groups per molecule , wherein weight percent is based on the total weight of the composition , and an article made from the composition has a tensile strength greater than or equal to 70 megaPascals (MPa) , as determined by ASTM D638 , an impact strength of greater than or equal to 3 kiloJoules per square meter (kJ/m) , as determined by ASTM D256 , and an elongation at break greater than or equal to 3% as determined by ASTM D638.2. The composition of claim 1 , wherein the poly(arylene sulfide) is poly(phenylene sulfide).4. The composition of claim 1 , wherein the novolac resin has an average of 6 or more epoxy groups per molecule.5. The composition of claim 1 , wherein the novolac resin has an average of 20 or more epoxy groups per molecule.6. The composition of claim 1 , further comprising a reinforcing filler.7. The composition of wherein the reinforcing filler comprises glass beads claim 6 , glass flake claim 6 , milled glass claim 6 , glass fibers claim 6 , and combinations ...

BLENDS OF POLYETHERIMIDE SULFONE AND POLY(ARYLENE SULFIDE) AND METHODS OF MAKING

A composition comprising a compatible blend of i) 15 to 45 wt % of a linear poly (arylene sulfide), ii) 50 to 85 wt % of a polyetherimide sulfone; and iii) 1 to 3 wt % of a novolac resin having an average of 2 or more epoxy groups per molecule. The composition can comprise a polyetherimide. An article made from the composition has a property selected from the group of (i) tensile strength greater than or equal to 90 megaPascals (MPa), as determined by ASTM D638, (ii) an impact strength of greater than or equal to 3 kiloJoules per square meter (kJ/m), as determined by ASTM D256, (iii) an elongation at break greater than or equal to 3% as determined by ASTM D638, (iv) a heat distortion temperature greater than or equal to 160° C. as determined by ASTM D648, and combinations of two or more of the foregoing properties. 1. A composition comprising a compatible blend of i) 15 to 45 weight percent of a linear poly (arylene sulfide) , ii) 50 to 85 weight percent of a polyetherimide sulfone and (iii) 1 to 3 weight percent of a novolac resin having an average of 2 or more epoxy groups per molecule ,{'sup': '2', 'wherein weight percent is based on the total weight of the composition, and an article made from the composition has a property selected from the group of (i) a tensile strength greater than or equal to 90 megaPascals (MPa), as determined by ASTM D638, (ii) an impact strength of greater than or equal to 3 kiloJoules per square meter (kJ/m), as determined by ASTM D256, (iii) an elongation at break greater than or equal to 3% as determined by ASTM D638, (iv) a heat deflection temperature that is greater than 160 C as determined by ASTM D648, and combinations of two or more of the foregoing properties.'}2. The composition of claim 1 , wherein the poly(arylene sulfide) is poly(phenylene sulfide).4. The composition of claim 1 , wherein the novolac resin has an average of 6 or more epoxy groups per molecule.5. The composition of claim 1 , wherein the novolac resin has an ...

Bed Bug Monitoring Device

The invention is directed to a bed bug monitoring device comprising a bed bug attractant element and a harborage section comprising a support member having a traversable surface and one or more protuberances depending therefrom. The harborage defines at least one entrance through which bed bugs attracted to the device can enter. The device can further include a base section placed over at least a portion of the traversable surface and adapted to by placed flush with the surface against which the device is to be placed. 137-. (canceled)38. A bed bug monitoring device comprising: (a) a bed bug attractant element; and (b) a harborage comprising a support member having a traversable surface and one or more protuberances thereon , the harborage being adapted to be placed flush with the surface where the device will be placed.39. The device of claim 38 , wherein the one or more protuberances define one or more channels.40. The device of claim 38 , wherein the traversable surface has an average surface roughness of at least 2.5 micrometers.41. The device of claim 38 , wherein the harborage further comprises a base section claim 38 , at least a portion of the base section comprising a transparent material and being adapted to be placed flush with the surface where the device will be placed.42. The device of claim 41 , wherein the base section comprises polycarbonate.43. The device of claim 39 , wherein the one or more protuberances are spaced to form channel widths of between 2 mm and 10 mm.44. The device of claim 39 , wherein the one or more channels have a top surface that is concave in cross section.45. The device of claim 40 , wherein the exposed area of the traversable surface possesses an average surface roughness of at least 3.0 micrometers.46. The device of claim 38 , wherein the support member comprises a material selected from the group consisting of acrylonitrile butadiene styrene and high impact polyethylene.47. The device of claim 38 , wherein at least a ...

Polymer blend compositions

Thermoplastic compositions having miscible and compatible immiscible polymer blends are disclosed. The miscible polymer blends have a single glass transition temperature. The compatible polymer blends have two glass transition temperatures.

EMOTION IDENTIFICATION SYSTEM AND METHOD

A system and method for identifying emotion in text that connotes authentic human expression, and training an engine that produces emotional analysis at various levels of granularity and numerical distribution across a set of emotions at each level of granularity. The method may include classifying textual data as emotional textual data or non-emotional textual data, and determining duration of an emotional state. 1. A method of classifying textual data as emotional textual data or non-emotional textual data comprising:providing, with a processor, a database of data indicators that each define emotional content of textual data;receiving, at a processor, first textual data authored by an individual;processing, with a processor, the first textual data to produce a first data indicator defining emotional content of the first textual data;inputting, with a processor, the first data indicator into an emotion similarity model and the data indicators of the database into the emotion similarity model to determine at least one similarity between the first data indicator and the data indicators of the database; andclassifying, with a processor, the first textual data as emotional textual data or non-emotional textual data based on the at least one similarity.2. The method of claim 1 , wherein the textual data of the database has been authored by at least one individual on a webpage of an online forum system.3. The method of claim 2 , wherein the textual data of the database has been tagged with at least one tag by an author of the textual data claim 2 , the at least one tag being associated with at least one emotion and associating at least a portion of the textual data of the database with the at least one emotion.4. The method of claim 1 , wherein the first data indicator is produced using textual analysis selected from a group consisting of latent semantic analysis claim 1 , and positive pointwise mutual information.5. The method of claim 1 , wherein the emotion similarity ...

EMOTION IDENTIFICATION SYSTEM AND METHOD

A system and method for identifying emotion in text that connotes authentic human expression, and training an engine that produces emotional analysis at various levels of granularity and numerical distribution across a set of emotions at each level of granularity. The method may include producing a chart of data transmissions referenced against time, comparing filtered data transmissions to a database, and selecting a database based on a demographic class of an author. 1. A method of producing a chart of data transmissions referenced against time comprising:providing, with a processor, a database of data indicators that each define emotional content of textual data;receiving, at a processor, a plurality of textual data transmissions sent by at least one individual during a span of time;processing, with a processor, the plurality of textual data transmissions to produce at least one data indicator defining emotional content of the plurality of textual data transmissions;inputting, with a processor, the at least one data indicator of the plurality of textual data transmissions into an emotion similarity model and the data indicators of the database into the emotion similarity model to determine at least one similarity between the at least one data indicator of the plurality of textual data transmissions and the data indicators of the database; andproducing, with a processor, a chart displaying at least one value corresponding to the at least one similarity referenced against at least a portion of the span of time.2. The method of claim 1 , wherein the textual data of the database has been authored by at least one individual on a webpage of an online forum system.3. The method of claim 2 , wherein the textual data of the database has been tagged with at least one tag by an author of the textual data claim 2 , the at least one tag being associated with at least one emotion and associating at least a portion of the textual data of the database with the at least one ...

UV-STABILIZED POLYSULFONES-V4

Compositions including a polysulfone and a UVA stabilizer. The polysulfone may be polysulfone (PSU), polyethersulfone (PES), polyphenylsulfone (PPSU) and mixtures thereof. The UVA stabilizer may include a benzotriazole moiety, a 1,3,5-triazine moiety, and/or a benzoxazinone moiety. 2. The composition according to claim 1 , wherein the UVA stabilizer present after processing the composition by at least one of blending claim 1 , extrusion claim 1 , molding and combinations thereof claim 1 , is at least 20% by weight of an initial loading of the UVA stabilizer.3. The composition according to claim 1 , wherein the UVA stabilizer is selected from the group consisting of 2-(2′Hydroxy-5-T-Octylphenyl)-Benzotriazole claim 1 , (2-(4 claim 1 ,6-Diphenyl-1 claim 1 ,3 claim 1 ,5-triazin-2-yl)-5-hexyloxyphenol) claim 1 , (2 claim 1 ,2′-Methylene bis[4-(1 claim 1 ,1 claim 1 ,3 claim 1 ,3-tetramethylbutyl)-6-(2H-benzotriazole-2-yl)phenol]) claim 1 , 2 claim 1 ,2′-(1 claim 1 ,4-Phenylene)bis(4H-3 claim 1 ,1-benzoxazin-4-one claim 1 , (Phenol claim 1 , 2-(2H-benzotriazol-2-yl)-4 claim 1 ,6-bis(1-methyl-1-phenylethyl) claim 1 , Tinuvin 1600 claim 1 , and mixtures thereof.4. The composition according to claim 1 , further comprising a filler.5. The composition of claim 4 , wherein the filler comprises glass fiber.6. The composition of claim 4 , wherein the filler comprises a carbon material.7. The composition according to claim 1 , further comprising a white pigment.8. The composition according to claim 4 , further comprising a pigment.9. The composition according to claim 7 , wherein the pigment is one selected from the group of pigment imparting a light color and pigments imparting a dark color.10. The composition according to claim 7 , wherein the pigment is one selected from the group consisting of TiO claim 7 , ZnS claim 7 , ZnO claim 7 , BaSO claim 7 , CaCl claim 7 , CaCOand mixtures thereof.11. The composition according to claim 7 , wherein the pigment is present in an amount ...

Thermal management system for an energy storage container

A thermal management system for an energy storage container includes an enclosed compartment containing an energy storage unit, an air temperature control unit configured to cool an interior of the enclosed compartment, and at least one inverter connected to a coolant circuit, which is separate from the air temperature control unit, and configured to be cooled by a coolant in the coolant circuit. The thermal management system also includes a radiator located outside of the enclosed compartment, the radiator being connected to the coolant circuit, wherein the coolant in the coolant circuit flows through the radiator, and at least one fan located alongside the radiator, outside of the enclosed compartment, the at least one fan being configured to blow air across the radiator to cool the coolant flowing through the radiator.

Insect Repellent

In one aspect, this invention relates to pest repellent composition comprising a fatty acid and an anthranilate ester. In another aspect, this invention relates to a method of repelling pests employing such composition. 1. A composition comprising an insect or acarid repellant amount of a composition comprising: (a) an anthranilate ester; and (b) a fatty acid.2. The composition of wherein said anthralinate ester is selected from the group consisting of dimethyl anthranilate claim 1 , methyl anthranilate claim 1 , ethyl anthranilate claim 1 , phenylethyl anthranilate and menthyl anthranilate.3. The composition of wherein said anthranilate ester is methyl anthranilate or dimethyl anthranilate.4. The composition of wherein said fatty acid is selected from the group consisting of saturated and unsaturated fatty acids containing from 8 to 24 carbon atoms.5. The composition of wherein said fatty acid contains from 13 to 21 carbon atoms.6. The composition of wherein said fatty acid is selected from the group consisting of oleic acid claim 1 , ricinoleic acid claim 1 , linoleic acid palmitic acid and stearic acid.7. The composition of wherein the fatty acid is oleic acid.8. The composition of wherein the weight ratio of fatty acid to anthranilate ester is from 1:10 to 20:1.9. The composition of wherein the weight ratio of fatty acid to anthranilate ester is from 1:5 to 10:1.10. The composition of wherein the weight ratio of fatty acid to anthranilate ester is from 1:1 to 5:1.11. The composition of wherein the composition further comprises a solvent.12. The composition of claim 11 , wherein the solvent is selected from a C-Calcohol claim 11 , an ester claim 11 , a ketone claim 11 , a petroleum distillate or a glycol.13. The composition of claim 1 , wherein the composition further comprises an antioxidant preservative agent.14. A method of repelling an insect or acarid pest comprising applying the composition of to a locus where such repelling is desired.15. The method of ...

ELECTRICAL TRACKING RESISTANCE COMPOSITIONS, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE THEREOF

A composition comprises, based on the total weight of the composition, 40 to 80 wt % of a polyetherimide; 10 to 50 wt % of talc; and 1 to 15 wt % of a polymer additive comprising a polyphthalamide, a poly(siloxane-etherimide) copolymer, aliphatic polyamide, or a combination comprising at least one of the foregoing; wherein the composition has a number of drops to tracking at 250 volts of greater than or equal to 50 drops determined according to ASTM D-3638-85. 1. A composition comprising , based on the total weight of the composition ,40 to 80 wt % of a polyetherimide;10 to 50 wt % of talc; and1 to 15 wt % of a polymer additive comprising a polyphthalamide, a poly(siloxane-etherimide) copolymer, aliphatic polyamide, or a combination comprising at least one of the foregoing;wherein the composition has a number of drops to tracking at 250 volts of greater than or equal to 50 drops determined according to ASTM D-3638-85.2. The composition of claim 1 , wherein the composition has a tensile strength greater than or equal to 65 MPa determined according to ASTM D638 and a tensile modulus greater than equal to 10 claim 1 ,000 GPa determined according to ASTM D638.5. The composition of claim 3 , wherein R is m-phenylene and Q is isopropylidene.7. The composition of claim 6 , wherein in the polysiloxane diamine claim 6 , R′ is methyl claim 6 , Ris 1 claim 6 ,3-propylene claim 6 , and E is 5 to 100; and wherein in the etherimide units claim 6 , R is phenylene and Z is a residue of bisphenol A.9. The composition of claim 8 , wherein each Gis a 1 claim 8 ,6-hexyl group.11. The composition of claim 1 , wherein talc has a D95 of 2 to 6 micrometers.12. The composition of comprising claim 1 , based on the total weight of the composition claim 1 ,40 to 70 wt % of a polyetherimide; and30 to 50 wt % of talc; and1 to 15 wt % of a polymer additive comprising a polyphthalamide, a poly(siloxane-etherimide) copolymer, aliphatic polyamide, or a combination comprising at least one of the ...

ELECTRICAL TRACKING RESISTANCE COMPOSITIONS, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE THEREOF

A composition comprises, based on the total weight of the composition, 45 wt % to 75 wt % of a polyetherimide; and 20 wt % to 45 wt % of talc; and 5 wt % to 15 wt % of a fluorinated polymer; wherein the composition has a number of drops to tracking at 250 volts of greater than or equal to 50 drops according to ASTM D-3638-85. 4. The composition of claim 3 , wherein R is m-phenylene and Q is isopropylidene.5. The composition of claim 3 , whereinat least 50 mole percent (mol %) of the R groups are bis(3,4′-phenylene)sulfone, bis(3,3′-phenylene)sulfone, or a combination comprising at least one of the foregoing and the remaining R groups are p-phenylene, m-phenylene or a combination comprising at least one of the foregoing; and Z is 2,2-(4-phenylene)isopropylidene.6. The composition of claim 1 , wherein the fluorinated polymer comprises polytetrafluoroethylene.8. The composition of claim 7 , wherein the composition has:a tensile strength greater than or equal to 70 MPa determined according to ASTM D638;a tensile modulus of greater than or equal to 6500 GPa determined according to ASTM method D638, anda heat deflection temperature of greater than or equal to 200° C. measured on 3.2 millimeter injection molded bar at 1.82 MPa stress according to ASTM D648.10. The composition of claim 9 , wherein the composition has:a tensile strength greater than or equal to 40 MPa determined according to ASTM D638;a tensile modulus of greater than or equal to 11,000 GPa determined according to ASTM method D638, anda heat deflection temperature of greater than or equal to 210° C. measured on 3.2 millimeter injection molded bar at 1.82 MPa stress according to ASTM D648.11. The composition of claim 1 , further comprising an additive selected from a processing aid claim 1 , a heat stabilizer claim 1 , a dye claim 1 , a flame retardant claim 1 , or a combination comprising at least one of the foregoing.12. An insulating material comprising the composition of .13. An article selected from a ...

ELECTRICAL TRACKING RESISTANCE COMPOSITIONS, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE THEREOF

A poly(siloxane-etherimide) composition comprising, based on the total weight of the composition, 70 to 90 wt % of a poly(siloxane-etherimide); and an additive comprising a polyester, a filler, or a combination thereof; wherein the filler comprises talc, calcium carbonate, or a combination comprising at least one of the foregoing; and wherein the composition has a number of drops to tracking at 250 volts of greater than or equal to 50 drops determined according to ASTM D-3638-85. 1. A composition comprising , based on the total weight of the composition ,70 to 90 wt % of a poly(siloxane-etherimide); andan additive comprising a polyester, a filler, or a combination thereof;wherein the filler comprises talc, calcium carbonate, or a combination comprising at least one of the foregoing; andwherein the composition has a number of drops to tracking at 250 volts of greater than or equal to 50 drops determined according to ASTM D-3638-85.2. The composition of comprising claim 1 , based on the total weight of the composition:75 to 90 wt % of a poly(siloxane-etherimide);5 to 18 wt % of the filler; and5 to 25 wt % of the polyester.3. The composition of claim 1 , wherein the composition has:a tensile strength greater than or equal to 20 MPa determined according to ASTM D638;a tensile modulus of greater than or equal to 600 GPa determined according to ASTM method D638;an unnotched Izod impact of greater than or equal to 400 J/m, determined at room temperature on 3.2 millimeter thick bars as per ASTM D256; anda melt flow rate of greater than or equal to 35 g/10 min, measured in accordance with ASTM D1238 at 337° C., using a 6.7 kilogram (kg) weight.4. The composition of comprising claim 1 , based on the total weight of the composition:75 to 80 wt % of a poly(siloxane-etherimide); and20 to 25 wt % of a polyester.5. The composition of claim 4 , wherein the composition has:a tensile strength greater than or equal to 25 MPa determined according to ASTM D638;a tensile modulus of ...

SUSTAINED RELEASE DOSAGE FORMS FOR A JAK1 INHIBITOR

This invention relates to sustained release dosage forms comprising {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, or a pharmaceutically acceptable salt thereof, and doses and methods related thereto. 1. A method of treating an autoimmune disease , a cancer , a myeloproliferative disorder , an inflammatory disease , a bone resorption disease , or organ transplant rejection in a patient in need thereof , comprising orally administering to said patient a once-daily dose of about 400 mg to about 600 mg on a free base basis of {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2 ,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile , or a pharmaceutically acceptable salt thereof , wherein the dose comprises one or more sustained release dosage forms each comprising {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2 ,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile , or a pharmaceutically acceptable salt thereof.2. A method according to claim 1 , wherein the method comprises administering to said patient the one or more sustained release dosage forms as a once-daily dosage of about 600 mg on a free base basis of {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2 claim 1 ,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile claim 1 , or a pharmaceutically acceptable salt thereof.3. A method according to claim 1 , wherein the one or more sustained release dosage forms are six dosage forms of about 100 mg on a free base basis of {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2 claim 1 ,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile claim 1 , or a pharmaceutically acceptable salt thereof.4. A method according to claim 1 , wherein the one or more sustained release dosage forms are three dosage ...

HARDWARE IMPLEMENTATION OF WINDOWED OPERATIONS IN THREE OR MORE DIMENSIONS

A data processing system and method are disclosed, for implementing a windowed operation in at least three traversed dimensions. The data processing system maps the windowed operation in at least three traversed dimensions to a plurality of constituent windowed operations in two traversed dimensions. This plurality of 2-D windowed operations is implemented as such in at least one hardware accelerator. The data processing system assembles the results of the constituent 2-D windowed operations to produce the result of the windowed operation in at least three traversed dimensions. 1. A method of implementing a windowed operation in at least three traversed dimensions , the windowed operation comprising applying a window having at least three dimensions to data having at least three traversed dimensions , with shifts of the window in all three traversed dimensions , the method comprising:mapping the windowed operation to a plurality of constituent 2-D windowed operations, each 2-D windowed operation comprising applying a slice of the window to a slice of the data, with shifts of the slice of the window in only two dimensions;implementing each of the plurality of 2-D windowed operations by at least one hardware accelerator, each 2-D windowed operation producing a respective partial result; andassembling the partial results to produce the result of the windowed operation.2. The method of claim 1 , comprising selecting two dimensions of the at least three traversed dimensions and mapping the windowed operation to a plurality of constituent 2-D windowed operations in the selected two dimensions.3. The method of claim 1 , wherein the data comprises zero-padded data claim 1 , and wherein mapping the windowed operation to the plurality of constituent 2-D windowed operations comprises:excluding from the plurality of constituent 2-D windowed operations a 2-D windowed operation that would be applied to a slice of the zero-padded data that consists solely of zeros.4. The method of ...

LASER-INDUCED GRAPHENE FORMATION IN POLYMER COMPOSITIONS

A method for forming a polymer/graphene nanocomposite includes providing a polymer matrix comprising a clear polymer and an additive effective to induce graphitization of the polymer at a wavelength in a range of 8.3 to 11 μm, and irradiating the polymer matrix with radiation comprising a wavelength in a range of 8.3 to 11 μm to provide the polymer/graphene nanocomposite. 1. A method for forming a polymer/graphene nanocomposite , the method comprising:providing a polymer matrix comprising a clear polymer and an additive effective to induce graphitization of the polymer at a wavelength in a range of 8.3 to 11 μm; andirradiating the polymer matrix with radiation comprising a wavelength in a range of 8.3 to 11 μm to provide the polymer/graphene nanocomposite.2. The method according to claim 1 , wherein the clear polymer comprises a cyclic olefin polymer claim 1 , fluoropolymer claim 1 , polyacetal claim 1 , poly(C1-6 alkyl)acrylate claim 1 , polyacrylamide claim 1 , polyacrylonitrile claim 1 , polyamide claim 1 , polyamideimide claim 1 , polyanhydride claim 1 , polyarylene ether claim 1 , polyarylene ether ketone claim 1 , polyarylene ketone claim 1 , polyarylene sulfide claim 1 , polyarylene sulfone claim 1 , polybenzothiazole claim 1 , polybenzoxazole claim 1 , polybenzimidazole claim 1 , polycarbonate claim 1 , polyester claim 1 , polyetherimide claim 1 , polyimide claim 1 , poly(C1-6 alkyl)methacrylate claim 1 , polymethacrylamide claim 1 , polyolefin claim 1 , polyoxadiazole claim 1 , polyoxymethylene claim 1 , polyphthalide claim 1 , polysilazane claim 1 , polysiloxane claim 1 , polystyrene claim 1 , polysulfide claim 1 , polysulfonamide claim 1 , polysulfonate claim 1 , polythioester claim 1 , polytriazine claim 1 , polyurea claim 1 , polyurethane claim 1 , vinyl polymer claim 1 , a thermosetting alkyd claim 1 , bismaleimide polymer claim 1 , bismaleimide triazine polymer claim 1 , cyanate ester polymer claim 1 , benzocyclobutene polymer claim 1 , diallyl ...

LASER-INDUCED GRAPHENE FORMATION IN POLYMER BLENDS

A method for forming a polymer/graphene nanocomposite includes providing a polymer blend comprising a polyetherimide and a polycarbonate; and irradiating the polymer blend with radiation comprising a wavelength in a range of 8.3 to 11 μm to provide the polymer/graphene nanocomposite. The polymer blend has a melt volume rate of 1 to 100 cm/10 min, preferably 5 to 75 cm/10 min, more preferably 10 to 50 cm/10 min, as determined at 360° C./5.0 kg in accordance with ISO 1133. 1. A method for forming a polymer/graphene nanocomposite , the method comprising:providing a polymer blend comprising a polyetherimide and a polycarbonate; andirradiating the polymer blend with radiation comprising a wavelength in a range of 8.3 to 11 μm to provide the polymer/graphene nanocomposite,{'sup': '3', 'wherein the polymer blend has a melt volume rate of 1 to 100 cm/10 min, as determined at 360° C./5.0 kg in accordance with ISO 1133.'}2. The method according to claim 1 , wherein:irradiating the polymer blend comprises using a laser, and{'sup': '−1', 'operating conditions of the laser comprise power in a range of 0.1 to 0.6 W, laser speed in a range of 1.7 to 2.5 cm s, pulse duration in a range of 10 to 30 μs, and resolution in a range of 500 to 1,000 ppi.'}3. The method according to claim 2 , further comprising adjusting one or more of the operating conditions of the laser.4. The method according to claim 1 , wherein the polycarbonate is a polycarbonate homopolymer claim 1 , a copolycarbonate claim 1 , a poly(carbonate-ester) claim 1 , a poly(carbonate-siloxane) claim 1 , a poly(carbonate-ester-siloxane) claim 1 , or a combination thereof.5. The method according to claim 1 , wherein the polycarbonate comprises a poly(carbonate-ester).6. The method according to claim 1 , wherein the polycarbonate comprises an isophthaloyl/terephthaloyl resorcinol poly(carbonate-ester).7. The method according to claim 1 , wherein the polycarbonate comprises a homopolycarbonate.8. The method according to ...

LASER-INDUCED GRAPHENE FORMATION IN POLYMERS

A method for forming a polymer/graphene nanocomposite includes irradiating a polymer comprising an aromatic poly(carbonate-ester), a poly(etherimide-sulfone), or a combination thereof with radiation comprising a wavelength in a range of 8.3 to 11 μm to provide the polymer/graphene nanocomposite. 1. A method for forming a polymer/graphene nanocomposite , the method comprising:irradiating a polymer comprising an aromatic poly(carbonate-ester), a poly(etherimide-sulfone), or a combination thereof with radiation comprising a wavelength in a range of 8.3 to 11 μm to provide the polymer/graphene nanocomposite.2. The method according to claim 1 , wherein:irradiating the polymer comprises using a laser, and{'sup': '−1', 'operating conditions of the laser comprise power in a range of 0.1 to 0.6 W, laser speed in a range of 1.7 to 2.5 cm s, pulse duration in a range of 10 to 30 μs, and resolution in a range of 500 to 1,000 ppi.'}3. The method according to claim 2 , further comprising adjusting one or more of the operating conditions of the laser to adjust a property of the polymer/graphene nanocomposite.4. The method according to claim 1 , wherein the polymer comprises an aromatic poly(carbonate-ester).5. The method according to claim 1 , wherein the polymer comprises a fully aromatic an aromatic poly(carbonate-ester).6. The method according to claim 1 , wherein the polymer comprises an isophthaloyl/terephthaloyl resorcinol poly(carbonate-ester).7. The method according to claim 1 , wherein the polymer comprises a poly(etherimide-sulfone).8. The method according to claim 1 , wherein the polymer/graphene nanocomposite has an electrical conductivity of 10 to 1 claim 1 ,000 S/m claim 1 , measured according to ASTM 257-75.9. The method according to claim 1 , wherein the polymer comprising the polymer/graphene nanocomposite has a degree of graphitization of 0.5 to 2 claim 1 , measured according to ISO TC 201 (Surface Chemical Analysis) and further according to the Versailles ...

Wax removal in a production line

In artificial lift production systems, a reduction in pressure and temperature as production fluids migrate to the surface can cause a buildup in the production tubing that reduces or stops production. To remove buildup, an ESP can be operated at low efficiency and low flow operating conditions to generate heat in the pump. The heat increases the temperature of the production fluid in the pump. When the heated production fluid is transported to the surface, the fluid increases the temperature of the production tubing resulting in a melting of the solidified wax blocking the production tubing. As the wax melts, the production fluid carries it toward the surface. Over time, the heated production fluid will melt enough solidified wax to open the production tubing to a full flow capacity, thus allowing standard production operation to continue.

Transcutaneous analyte sensor systems and methods

Sensor systems can be used to measure an analyte concentration. Sensor systems can include a base having a distal side configured to face towards a person's skin. An adhesive can couple the base to the skin. A transcutaneous analyte measurement sensor can be coupled to the base and can be located at least partially in the host. A transmitter can be coupled to the base and can transmit analyte measurement data to a remote device.

ELECTRICAL TRACKING RESISTANCE COMPOSITIONS, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE THEREOF

A composition comprises, based on the total weight of the composition, 50 wt % to 90 wt % of a polyetherimide; and 10 wt % to 50 wt % of a filler comprising talc, titanium dioxide, zirconium oxide, neutral aluminum oxide, or a combination comprising at least one of the foregoing; wherein the composition has a number of drops to tracking at 250 volts of greater than or equal to 50 drops determined according to ASTM D-3638-85. 1. A composition comprising , based on the total weight of the composition ,50 wt % to 90 wt % of a polyetherimide; and10 wt % to 50 wt % of a filler comprising talc, titanium dioxide, zirconium oxide, neutral aluminum oxide, or a combination comprising at least one of the foregoing;wherein the composition has a number of drops to tracking at 250 volts of greater than or equal to 50 drops determined according to ASTM D-3638-85.2. The composition of claim 1 , wherein the composition has a tensile strength greater than or equal to 30 MPa determined according to ASTM D638 and a tensile modulus greater than equal to 4 claim 1 ,000 GPa determined according to ASTM D638.3. The composition of claim 1 , wherein the degradation temperature difference between the polyetherimide and a blend of the polyetherimide and the filler is less than 10° C.6. The composition of claim 4 , whereinat least 50 mole percent (mol %) of the R groups are bis(3,4′-phenylene)sulfone, bis(3,3′-phenylene)sulfone, or a combination comprising at least one of the foregoing and the remaining R groups are p-phenylene, m-phenylene or a combination comprising at least one of the foregoing;and Z is 2,2-(4-phenylene)isopropylidene.7. The composition of claim 1 , wherein the filler comprises talc.8. The composition of claim 7 , wherein the talc has a D95 of 2 micrometers to 6 micrometers.9. The composition of claim 1 , comprising claim 1 , based on the total weight of the composition claim 1 ,50 wt % to 65 wt % of a polyetherimide; and35 wt % to 50 wt % of talc having a D95 of 3.5 ...

Systems and methods for evaluating the brain after onset of a stroke using computed tomography angiography

In one embodiment, a patient's brain is evaluated after onset of a stroke by capturing computed tomography angiography (CTA) images of the brain, analyzing the CTA images with a CTA image analysis program to evaluate the patient's brain, and generating results based upon the analysis that provide an assessment of the brain. In some cases, the CTA image analysis program comprises a machine-learning algorithm that has been trained on the results of perfusion imaging analysis.

Solid forms of ((s)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile

The present disclosure reports solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile.

Methods and systems for dynamic monitoring through graphical user interfaces

Methods and systems for monitoring through graphical user interfaces are disclosed. In one aspect, a system is disclosed that includes a processor and data storage including instructions that, when executed by the processor, cause the system to perform operations. The operations include maintaining an input file including predetermined criteria for a plurality of factors, receiving a model dataset generated using a model, based on the input file and the model dataset, generating a first graphical user interface that includes a graphical illustration of a subset of the plurality of factors, a model risk for the model, and a selectable feature associated with a selected factor in the subset and a selected time period. The operations further include receiving through the first graphical user interface a selection of the selectable feature, and, in response, generating a second graphical user interface that recolors a portion of the first graphical user interface.

Modulators of cystic fibrosis transmembrane conductance regulator

The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.

FOAMED THERMOPLASTIC MATERIAL, METHOD FOR THE MANUFACTURE THEREOF, ARTICLES PREPARED THEREFROM, AND ARTICLE-FORMING METHOD

A foamed thermoplastic material includes a thermoplastic material exhibiting, in its unfoamed state, a particular flammability index, flame growth rate, and specific extinction area. The foamed thermoplastic material further includes a plurality of cells having a number average mean diameter of 5 to 150 micrometers present in an amount effective to provide the foamed thermoplastic material with a density that is 10 to 90 percent of the density of the unfoamed thermoplastic material. The foamed thermoplastic material exhibits a desirable tensile elongation and dielectric constant. A process for forming the foamed thermoplastic material, articles including the foamed thermoplastic material, and an article-forming process are also described. 1. A foamed thermoplastic material comprising: [ a flammability index of 0.1 to 15, determined according to ASTM D7309 Method A at a heating rate of 1° C. per second under nitrogen from 25 to 750° C.;', {'sup': '2', 'a flame growth rate of 0.1 to 1.5 kW/ms, determined according to ASTM E1354 or ISO 5660 using an applied heat flux of 35 kilowatt per square meter;'}, 'a specific extinction area of 300 to 1200 square meters per kilogram, determined according to ASTM E1354 or ISO 5660 using an applied heat flux of 35 kilowatt per square meter;', 'a tensile elongation of greater than 100%, measured according to UL 1581 at a temperature of 23° C., using a coated wire test sample; and', 'a dielectric constant of 2 to 4, determined according to ASTM D150-11 at 1 MHz; and, 'in its unfoamed state,'}, a tensile elongation of 100 to 500%, measured according to UL 1581 at a temperature of 23° C., using a coated wire test sample; and', 'a dielectric constant of 1.4 to 4, determined according to ASTM D150-11 at 1 MHz; and, 'in its foamed state,'}], 'a thermoplastic material exhibiting,'}a plurality of cells having a number average mean diameter of 5 to 150 micrometers;wherein the cells are present in an amount effective to provide the foamed ...

Sensors for continuous analyte monitoring, and related methods

Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

ELECTRICAL TRACKING RESISTANCE COMPOSITIONS, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE THEREOF

A composition comprises, based on the total weight of the composition, 25 wt % to 50 wt % of a polyetherimide; and 50 wt % to 75 wt % of a polyphthalamide; wherein the composition has a number of drops to tracking at 250 volts of greater than or equal to 50 drops determined according to ASTM D-3638-85. 1. A composition comprising , based on the total weight of the composition ,25 wt % to 50 wt % of a polyetherimide; and50 wt % to 75 wt % of a polyphthalamide;wherein the composition has a number of drops to tracking at 250 volts of greater than or equal to 50 drops determined according to ASTM D-3638-85.3. The composition of claim 1 , wherein the composition has a tensile strength greater than or equal to 60 MPa determined according to ASTM D638 claim 1 , a tensile modulus greater than equal to 2500 GPa determined according to ASTM D638 claim 1 , and notched Izod impact strength greater than or equal to 45 J/m measured at room temperature on 3.2 millimeter thick bars as per ASTM D2564. The composition of claim 1 , wherein the composition has heat defection temperature of greater than or equal to 110° C. measured on 3.2 millimeter injection molded bar at 1.82 MPa stress according to ASTM D648.5. A composition comprising claim 1 , based on the total weight of the composition claim 1 ,25 wt % to 60 wt % of a polyetherimide; and40 wt % to 75 wt % of a polyester;wherein the composition has a number of drops to tracking at 250 volts of greater than or equal to 50 drops determined according to ASTM D-3638-85.6. The composition of claim 5 , wherein the polyester is a linear aliphatic polyester.7. The composition of claim 5 , wherein the polyester comprises poly(ethylene terephthalate) and poly(butylene terephthalate) claim 5 , or a combination comprising at least one of the foregoing.8. The composition of claim 5 , wherein the composition has a tensile strength greater than or equal to 40 MPa determined according to ASTM D638 claim 5 , a tensile modulus greater than equal to ...

POLYIMIDE RESIN COMPOSITIONS

A thermoplastic composition comprises a polymer blend. The polymer blend comprises a first polyimide and a second polyimide. The first polyimide has repeating units derived from a first dianhydride and a first diamine. The second polyimide has repeating units derived from a second dianhydride and a second diamine. Either the first dianhydride and the second dianhydride are the same or the first diamine and the second diamine are the same. 1. A thermoplastic composition comprising a non-delaminated polymer blend wherein the polymer blend comprises:a first polyimide comprising structural units derived from a first dianhydride and a first diamine; anda second polyimide comprising structural units derived from a second dianhydride and a second diamine; andwherein the first dianhydride and the second dianhydride are different and the first diamine and the second diamine are the same.2. The thermoplastic composition of claim 1 , wherein the polymer blend is a miscible polymer blend.3. The thermoplastic composition of claim 1 , wherein the polymer blend is a compatible polymer blend.5. The thermoplastic composition of claim 1 , wherein the first dianhydride and the second dianhydride are selected from the group consisting of bisphenol A dianhydride claim 1 , oxydiphthalic anhydride (ODPA) and combinations thereof.6. The thermoplastic composition of claim 1 , wherein the first diamine and the second diamine are selected from the group consisting of m-phenylenediamine claim 1 , p-phenylenediamine claim 1 , diamino diaryl sulfones and combinations thereof.7. The thermoplastic composition of claim 1 , wherein first polyimide comprises structural units derived from oxydiphthalic anhydride (ODPA) and diamino diaryl sulfone (DAS) and the second polyimide comprises structural units derived from bisphenol-A dianhydride (BPADA) and diamino diarylsulfone (DAS).8. The thermoplastic composition of claim 1 , wherein claim 1 ,the first polyimide is present in an amount of 50 to 99 weight ...

SUSTAINED RELEASE DOSAGE FORMS FOR A JAK1 INHIBITOR

This invention relates to sustained release dosage forms comprising {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, or a pharmaceutically acceptable salt thereof, and doses and methods related thereto. 145-. (canceled)46. A method of treating a disease selected from psoriasis , rheumatoid arthritis , primary myelofibrosis (PMF) , post-polycythemia vera myelofibrosis , and post-essential thrombocythemia myelofibrosis in a patient in need thereof , comprising orally administering to said patient a once-daily dose of one or more sustained release tablets , each comprising:(i) {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, or a pharmaceutically acceptable salt thereof;(ii) a first hypromellose characterized by having an apparent viscosity at a concentration of 2% in water of 80 cP to 120 cP;(iii) a second hypromellose, characterized by having an apparent viscosity at a concentration of 2% in water of 3000 cP to 5600 cP,wherein the tablet comprises 8% to 20% of the first and second hypromelloses;(iv) 16% to 22% by weight of microcrystalline cellulose; and(v) 45% to 55% by weight of lactose monohydrate;{'sub': max', '12h, 'wherein oral administration of the one or more of the sustained release tablets to a fasted individual provides a ratio of mean peak plasma concentration (C) to mean 12-hour plasma concentration (C) of {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile of 9 to 40.'}47. The method of claim 46 , wherein oral administration of the one or more of the sustained release tablets to a fasted patient provides a ratio of mean peak plasma concentration (C) to mean 12-hour plasma concentration (C) of {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H- ...

Coating Compositions Having Improved Corrosion Resistance

The present invention is directed towards curable film-forming coating compositions comprising metal particles; an alkaline earth metal compound comprising an alkaline earth metal oxide, an alkaline earth metal carbonate, an alkaline earth metal hydroxide, an alkaline earth metal sulfate, an alkaline earth metal monocarboxylate, an alkaline earth metal phosphate, or combinations thereof; and an organic film-forming binder. Also disclosed are methods of making curable film-forming coating compositions, methods of coating substrates, and coated substrates resulting therefrom.

IMPROVED DIELECTRIC STRENGTH COMPOSITIONS

A molded article having improved dielectric strength is disclosed. The molded article is formed by (a) providing a thermoplastic resin composition including a base polymer resin and a mold release agent; and (b) molding the thermoplastic resin composition to form the molded article. The dielectric strength of the molded article formed is higher than a comparator molded article comprising the thermoplastic resin composition in the absence of the mold release agent. 1. A process for the production of a molded article , the process comprising:(a) providing a thermoplastic resin composition including a base polymer resin and a mold release agent; and(b) molding the thermoplastic resin composition to form the molded article, wherein the dielectric strength of the molded article is higher than a comparator molded article comprising the thermoplastic resin composition in the absence of the mold release agent.2. The process of claim 1 , wherein the molding includes at least one melt forming process selected from the group consisting of: injection molding claim 1 , blow molding claim 1 , sheet and film extrusion claim 1 , profile extrusion claim 1 , thermoforming claim 1 , additive manufacturing claim 1 , compression molding claim 1 , fiber extrusion claim 1 , and powder sintering.3. The process of claim 2 , wherein the melt forming process includes injection molding.4. The process of claim 1 , wherein the base polymer resin comprises polyetherimide and the polyetherimide has a weight average molecular weight of at least about 20 claim 1 ,000 to about 150 claim 1 ,000 grams per mole (g/mol).5. The process of claim 1 , wherein the mold release agent comprises high density polyethylene.6. The process of claim 1 , wherein the dielectric strength of the molded article is at least 10% higher than the dielectric strength of the comparator molded article.7. The process of claim 6 , wherein the dielectric strength of the molded article is at least 40% higher than the dielectric ...

COMPATIBILIZED COMPOSITIONS, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE THEREOF

A thermoplastic composition comprises, based on the total weight of the thermoplastic composition, 10 to 45 wt. % of a poly(etherimide); 35 to 90 wt. % of a polycarbonate component comprising a polycarbonate homopolymer, a poly(carbonate-siloxane), or a combination thereof; 0.5 to 20 wt. % of a compatibilizer polycarbonate component comprising a poly(carbonate-arylate ester), a phthalimidine copolycarbonate, or a combination thereof; up to 5 wt. % of an ultraviolet light stabilizer; and 0 to 20 wt. % of TiO, wherein a sample of the composition has a 50% higher notched Izod impact energy value compared to the composition without the compatibilizer component. 1. A thermoplastic composition comprising , based on the total weight of the thermoplastic composition ,10 to 45 wt. % of a poly(etherimide);35 to 90 wt. % of a polycarbonate component comprising a polycarbonate homopolymer, a poly(carbonate-siloxane), or a combination thereof;0.5 to 20 wt. % of a compatibilizer polycarbonate component comprising a poly(carbonate-arylate ester), a phthalimidine copolycarbonate, or a combination thereof;up to 5 wt. % of an ultraviolet light stabilizer; and{'sub': '2', '0 to 20 wt. % of TiO;'}wherein a sample of the composition hasa 50% higher notched Izod impact energy value compared to the composition without the compatibilizer component measured at 23° C. according to ISO 180/1A using a multipurpose test specimen in accordance with ISO 3167 TYPE A.2. The composition of comprising claim 1 , based on the weight of the composition:10 to 30 wt. % of a poly(etherimide);30 to 50 wt. % of a polycarbonate homopolymer;30 to 50 wt. % of a poly(carbonate-siloxane) copolymer; and0.5 to 15 wt. % of compatibilizer polycarbonate component comprising a poly(carbonate-arylate ester), a phthalimidine copolycarbonate, or a combination thereof;wherein a sample of the composition has{'sup': '2', 'a notched Izod impact value of greater than or equal to 30 kJ/m, measured at 23° C. according to ISO 180 ...

SUSTAINED RELEASE DOSAGE FORMS FOR A JAK1 INHIBITOR

This invention relates to sustained release dosage forms comprising {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, or a pharmaceutically acceptable salt thereof, and doses and methods related thereto. 145-. (canceled)46. A sustained release dosage form comprising(i) {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, or a pharmaceutically acceptable salt thereof;(ii) a first hypromellose; and(iii) a second hypromellose.47. The dosage form of claim 46 , wherein the first hypromellose is characterized by having an apparent viscosity at a concentration of 2% in water of about 80 cP to about 120 cP.48. The dosage form of claim 46 , wherein the second hypromellose is characterized by having an apparent viscosity at a concentration of 2% in water of about 3000 cP to about 5600 cP.49. The dosage form of claim 46 , wherein the first hypromellose is characterized by having an apparent viscosity at a concentration of 2% in water of about 80 cP to about 120 cP claim 46 , and wherein the second hypromellose is characterized by having an apparent viscosity at a concentration of 2% in water of about 3000 cP to about 5600 cP.50. The dosage form of claim 46 , wherein the dosage form comprises about 8% to about 20% of the first and second hypromelloses.51. The dosage form of claim 46 , wherein the dosage form comprises about 10% to about 15% of the first and second hypromelloses.52. The dosage form of claim 46 , further comprising one or more excipients independently selected from microcrystalline celluloses claim 46 , magnesium stearate claim 46 , lactose and lactose monohydrate.53. The dosage form of claim 46 , further comprises about 16% to about 22% by weight of microcrystalline cellulose.54. The dosage form of claim 46 , wherein the dosage form further comprises about 45% to about 55% ...

EXTRUSION PROCESS FOR COATING WIRE, AND WIRES MADE THEREFROM

A method of making a wire with multiple coating layers can comprise: preheating a wire to a temperature Tto form a pre-heated wire; using a first extruder to coat the pre-heated wire with the first coating material to form a first coated wire; passing the first coated wire to a second extruder without storing the first coated wire, coating the first coated wire with a second coating material to form a second coated wire; and cooling the second coated wire.

COMPATIBILIZED COMPOSITIONS, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE THEREOF

A thermoplastic composition comprises, based on the total weight of the thermoplastic composition, 10 to 45 wt. % of a poly(etherimide); 35 to 90 wt. % of a poly(carbonate-siloxane); 0.5 to 20 wt. % of compatibilizer polycarbonate component comprising a poly(carbonate-arylate ester); up to 15 wt. % of an ultraviolet light stabilizer; and 0 to 30 wt. % of TiO2; wherein a sample of the composition has a notched Izod impact energy of at least 200 J/m at 23° C. measured in accordance to ASTM D256; and an at least 50% higher notched Izod impact energy value compared to the composition without the compatibilizer component measured in accordance to ASTM D256. 1. A thermoplastic composition comprising , based on the total weight of the thermoplastic composition ,10 to 45 wt. % of a poly(etherimide);35 to 90 wt. % of a poly(carbonate-siloxane);0.5 to 20 wt. % of compatibilizer polycarbonate component comprising a poly(carbonate-arylate ester);up to 15 wt. % of an ultraviolet light stabilizer; and{'sub': '2', '0 to 30 wt. % of TiO;'}wherein a sample of the composition hasa notched Izod impact energy of at least 200 J/m at 23° C. measured in accordance to ASTM D256; andan at least 50% higher notched Izod impact energy value compared to the composition without the compatibilizer component measured in accordance to ASTM D256.2. A thermoplastic composition comprising , based on the weight of the composition:20 to 35 wt. % of a poly(etherimide);50 to 75 wt. % of a poly(carbonate-siloxane); and5 to 35 wt. % of compatibilizer polycarbonate component comprising a poly(carbonate-arylate ester); and0 to 15 wt. % of an ultraviolet light stabilizer; and0 to 30 wt. % of titanium dioxide; andwherein a sample of the composition has a notched Izod impact energy value greater than 300 J/m at room temperature compared to the composition without the compatibilizer component measured in accordance to ASTM D256; andwherein a sample of the composition has a poly(etherimide) domain size in at least ...

Sensors for continuous analyte monitoring, and related methods

Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Solid forms of ((s)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile

The present disclosure reports solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile.

Polymorphic forms of rad1901-2hcl

Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.

Local augmented reality persistent sticker objects

Systems and methods for local augmented reality (AR) tracking of an AR object are disclosed. In one example embodiment a device captures a series of video image frames. A user input is received at the device associating a first portion of a first image of the video image frames with an AR sticker object and a target. A first target template is generated to track the target across frames of the video image frames. In some embodiments, global tracking based on a determination that the target is outside a boundary area is used. The global tracking comprises using a global tracking template for tracking movement in the video image frames captured following the determination that the target is outside the boundary area. When the global tracking determines that the target is within the boundary area, local tracking is resumed along with presentation of the AR sticker object on an output display of the device.

Catalytic steam gasification process with recovery and recycle of alkali metal compounds

A high efficiency gasification process for converting carbonaceous solids to methane and apparatus for its practice are described. The process includes reacting steam and carbonaceous solids comprising ash in the presence of alkali metal catalyst in a gasification reactor to produce combustible gases and char particles comprising ash and alkali metal catalyst constituents, treating a stream of such char particles in an alkali metal catalyst recovery system to recover the catalyst constituents as alkali metal compounds, and recycling such recovered compounds. Within the alkali metal catalyst recovery system the process includes quenching the stream of char particles with water whereby such particles are cooled and fractured, dissolving soluble alkali metal catalyst constituents from the fractured solids to form a first alkali metal catalyst solution and washed solids, optionally reacting the washed solids in alkaline solution to form a second alkali metal catalyst solution, upgrading said first and optional second alkali solution to recover the alkali metal catalyst constituents as said alkali metal compounds.

Heterogeneous ziegler-natta catalyst system and a process for olefin polymerization using the same

Method and system for distributing security policies

A method and system for distributing and enforcing security policies is provided. A firewall agent executing at a host computer system that is to be protected receives security policies for the enforcement engines responsible for enforcing the security policies on the host computer system. A security policy has rules that each provide a condition and action to be performed when the condition is satisfied. A rule also has a rule type that is used by the distribution system to identify the security components that are responsible for enforcing the rules. To distribute the security policies that have been received at a host computer system, the firewall agent identifies to which enforcement engine a rule applies based in part on rule type. The firewall agent then distributes the rule to the identified enforcement engine, which then enforces the rule.

Heterogeneous ziegler-natta catalyst system and a process for olefin polymerization using the same

The present disclosure provides a heterogeneous Ziegler-Natta catalyst system to be used in the preparation of ultra-high molecular weight polymers (UHMWP). The system includes at least one procatalyst, at least one co-catalyst, at least one hydrocarbon medium and at least one external donor, wherein the ratio of elemental magnesium to elemental titanium to halide, in the procatalyst, is 1 : 1.3: 3.7; the ratio of elemental aluminum, present in the co-catalyst to elemental titanium, present in the procatalyst, ranges between 6:1 and 12: 1; and the ratio of elemental silicon, present in the external donor to elemental titanium, present in the procatalyst, ranges between 1 : 10 and 10: 1. The present disclosure also provides a process for preparation of UHMWPE using the heterogeneous Ziegler-Natta catalyst system of the present disclosure.

Heterogeneous ziegler-natta catalyst system and a process for olefin polymerization using the same

The present disclosure provides a heterogeneous Ziegler-Natta catalyst system to be used in the preparation of ultra-high molecular weight polymers (UHMWP). The system includes at least one procatalyst, at least one co-catalyst, at least one hydrocarbon medium and at least one external donor, wherein the ratio of elemental magnesium to elemental titanium to halide, in the procatalyst, is 1:1.3:3.7; the ratio of elemental aluminum, present in the co-catalyst to elemental titanium, present in the procatalyst, ranges between 6:1 and 12:1; and the ratio of elemental silicon, present in the external donor to elemental titanium, present in the procatalyst, ranges between 1:10 and 10:1. The present disclosure also provides a process for preparation of UHMWPE using the heterogeneous Ziegler-Natta catalyst system of the present disclosure.

Improved poly aryl ether ketone polymer blends

Phase separated blends of polyaryl ether ketones, polyaryl ketones, polyether ketones, polyether ether ketones and mixtures thereof with at least one polysulfone etherimide, wherein the polysulfone etherimide has greater than or equal to 50 mole% of the polymer linkages contain at least one aryl sulfone group are described. Such blends have improved load bearing capability at high temperature. In another aspect a high crystallization temperature, especially at fast cooling rates, is achieved.

Aromatic polyketone and polysiloxane/polyimide block copolymer composition

A composition comprises a blend of an aromatic polyketone and a polysiloxane/polyimide block copolymer. The composition can further comprise one or more additives.

Blends of poly aryl ether ketones and polyetherimide sulfones

Phase separated blends of polyaryl ether ketones, polyaryl ketones, polyether ketones, polyether ether ketones and mixtures thereof with at least one polysulfone etherimide, wherein the polysulfone etherimide has greater than or equal to 50 mole% of the polymer linkages contain at least one aryl sulfone group are described. Such blends have improved load bearing capability at high temperature. In another aspect a high crystallization temperature, especially at fast cooling rates, is achieved.

Aromatic polyketone and polysiloxane/polyimide block copolymer composition

A composition comprises a blend of an aromatic polyketone and a polysiloxane/polyimide block copolymer. The composition can further comprise one or more additives.

Poly aryl ether ketone polymer blends

Filled phase-separated blends of polyaryl ether ketones, polyaryl ketones, polyether ketones, polyether ether ketones and mixtures thereof with at least one polysulfone etherimide, wherein the polysulfone etherimide has greater than or equal to 50 mole % of the polymer linkages contain at least one aryl sulfone group are described. Such filled blends have improved load-bearing capability at high temperature. In another aspect the filled blends have a higher crystallization temperature, especially at fast cooling rates.

Annular or tubular shaped articles of novel polymer blends

The present invention is directed to a tubular article of manufacture in an annular or tubular shape having an outer diameter, an inner diameter and a length comprising one or more materials selected from the group consisting of: a) an immiscible blend of polymers comprising one or more polyetherimides, having more than one glass transition temperature wherein the polyetherimide has a glass transition temperature greater than 217° Celsius; b) a miscible blend of polymers, comprising one or more polyetherimides, having a single glass transition temperature greater than 180° Celsius; or, c) a single polyetherimide having a glass transition temperature of greater than 247° Celsius

heterogeneous ziegler-natta catalyst system and a process for olefin polymerization using the same

resumo “sistema de catalisador ziegler-natta heterogêneo e um processo para polimerização de olefina com uso do mesmo” a presente revelação refere-se a um sistema de catalisador ziegler-natta heterogêneo a ser usado na preparação de polímeros de altíssimo peso molecular (uhmwp). o sistema inclui pelo menos um pró-catalisador, pelo menos um cocatalisador, pelo menos um meio de hidrocarboneto e pelo menos um doador externo, em que a razão de magnésio elemental para titânio elemental para halogeneto, no pró-catalisador, é 1:1,3:3,7, a razão de alumínio elemental, presente no cocatalisador para titânio elemental, presente no pró-catalisador, está situada na faixa entre 6:1 e 12:1 e a razão de silício elemental, presente no doador externo para titânio elemental, presente no pró-catalisador, está situada na faixa entre 1:10 e 10:1. a presente revelação também se refere a um processo para preparação de uhmwpe com uso do sistema de catalisador ziegler-natta heterogêneo da presente revelação. abstract heterogeneous ziegler-natta catalyst system and a process for olefin polymerization using it the present disclosure refers to a heterogeneous ziegler-natta catalyst system to be used in the preparation of very high molecular weight (uhmwp) polymers . the system includes at least one procatalyst, at least one cocatalyst, at least one hydrocarbon medium, and at least one external donor, wherein the ratio of elemental magnesium to elemental titanium to halide in the procatalyst is 1:1 ,3:3,7, the ratio of elemental aluminum, present in the cocatalyst to elemental titanium, present in the pro-catalyst, is situated in the range between 6:1 and 12:1 and the ratio of elemental silicon, present in the external donor to Elemental titanium, present in the procatalyst, is situated in the range between 1:10 and 10:1. the present disclosure also relates to a process for preparing uhmwpe using the heterogeneous ziegler-natta catalyst system of the present disclosure.

Heterogeneous ziegler-natta catalyst system and a process for olefin polymerization using the same

The present disclosure provides a heterogeneous Ziegler-Natta catalyst system to be used in the preparation of ultra-high molecular weight polymers (UHMWP). The system includes at least one procatalyst, at least one co-catalyst, at least one hydrocarbon medium and at least one external donor, wherein the ratio of elemental magnesium to elemental titanium to halide, in the procatalyst, is 1 : 1.3: 3.7; the ratio of elemental aluminum, present in the co-catalyst to elemental titanium, present in the procatalyst, ranges between 6:1 and 12: 1; and the ratio of elemental silicon, present in the external donor to elemental titanium, present in the procatalyst, ranges between 1 : 10 and 10: 1. The present disclosure also provides a process for preparation of UHMWPE using the heterogeneous Ziegler-Natta catalyst system of the present disclosure.

Cross-linked polyester toners and process of making such toners

Cross-linked toner resin having linear portions and cross-linked portions of high density microgel particles, where the toner resin is an unsaturated polyester resin, is prepared using a liquid chemical initiator such as 1,1-bis(t-butyl peroxy)-3,3,5-trimethylcyclohexane so that the cross-linked resin achieved contains less than 0.20 percent by weight of acids. In particular, the cross-linked toner resin is free of benzoic acid. The method of making the cross-linked toner resin includes (a) spraying the liquid chemical initiator onto the unsaturated polyester resin prior to, during or subsequent to melting of the unsaturated polyester resin to form a polymer melt; and (b) subsequently cross-linking the polymer melt under high shear to form the cross-linked toner resin.

Processes relating to the alkylation of pyrazoles

The present invention relates to processes for the preparation of a compound of formula (I) comprising reacting a compound of formula (IV) with a compound of formula III or (IIIA) in the presence of an acid; wherein R 1 is C 1 -C 4 haloalkyl; R 2 is optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R 3 is methyl or ethyl; R 4 is hydrogen, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; and n is 0 or 1.

Process for the preparation of 3-haloalkylpyrazoles

The present invention provides a process for the preparation of a compound of formula (I) wherein R 1 is C 1 -C 4 haloalkyl; R 2 is optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; and R 3 is methyl or ethyl; comprising reacting a compound of formula (IV) wherein R 1 , R 2 and R 3 are as defined for the compound of formula I; with an alkylating agent in the presence of an amide.

Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form

Polyetherimide composition, film, process, and article

A polymer composition comprising, by weight, from about 50% to about 95% polyetherimide resin and from about 5% to about 50% inorganic substance. The polymer composition when formed into a film has a coefficient of thermal expansion of less than about 50 ppm/°C.

Sensors for continuous analyte monitoring, and related methods

Sensor devices including dissolvable tissue-piercing tips can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Fault discrimination and responsive processing based on data and context

Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

Fault discrimination and responsive processing based on data and context

Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

Sensors for continuous analyte monitoring, and related methods

Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Fault discrimination and responsive processing based on data and context

Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

Sensors for continuous analyte monitoring, and related methods

Sensor devices including dissolvable tissue-piercing tips can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Systems, devices, and methods to compensate for temperature effects on sensors

This document discusses, among other things, systems and methods to compensate for the effects of temperature on sensors, such as analyte sensor. An example method may include determining a temperature-compensated glucose concentration level by receiving a temperature signal indicative of a temperature parameter of an external component, receiving a glucose signal indicative of an in vivo glucose concentration level, and determining a compensated glucose concentration level based on the glucose signal, the temperature signal, and a delay parameter.

Systems, devices, and methods to compensate for temperature effects on sensors

This document discusses, among other things, systems and methods to compensate for the effects of temperature on sensors, such as analyte sensor. An example method may include determining a temperature-compensated glucose concentration level by receiving a temperature signal indicative of a temperature parameter of an external component, receiving a glucose signal indicative of an in vivo glucose concentration level, and determining a compensated glucose concentration level based on the glucose signal, the temperature signal, and a delay parameter.

Catalytic steam gasification process with recovery and recycle of alkali metal compounds

A high efficiency gasification process for converting carbonaceous solids to methane and apparatus for its practice are described. The process includes reacting steam and carbonaceous solids comprising ash in the presence of alkali metal catalyst in a gasification reactor to produce combustible gases and char particles comprising ash and alkali metal catalyst constituents, treating a stream of such char particles in an alkali metal catalyst recovery system to recover the catalyst constituents as alkali metal compounds, and recycling such recovered compounds. Within the alkali metal catalyst recovery system the process includes quenching the stream of char particles with water whereby such particles are cooled and fractured, dissolving soluble alkali metal catalyst constituents from the fractured solids to form a first alkali metal catalyst solution and washed solids, optionally reacting the washed solids in alkaline solution to form a second alkali metal catalyst solution, upgrading said first and optional second alkali solution to recover the alkali metal catalyst constituents as said alkali metal compounds.

Mild catalytic steam gasification process

The present invention provides an improved alkali metal catalyzed steam gasification process that utilizes a CO2 trap material and/or a mineral binder material within the gasifier. The process optimally achieves over 90% carbon conversion with over 80% yield of methane. The raw gas product can be used directly as fuel. The catalyst can be recovered from the solid purge and recycled to the gasifier and/or the CO2 trap can be regenerated and recycled to the gasifier.

method for catalytic gasification of carbonaceous material in combustible gases

Mild catalytic steam gasification process

The present invention provides an improved alkali metal catalyzed steam gasification process that utilizes a CO2 trap material and/or a mineral binder material within the gasifier. The process optimally achieves over 90% carbon conversion with over 80% yield of methane. The raw gas product can be used directly as fuel. The catalyst can be recovered from the solid purge and recycled to the gasifier and/or the CO2 trap can be regenerated and recycled to the gasifier.

Mild catalytic steam gasification process

The present invention provides an improved alkali metal catalyzed steam gasification process that utilizes a CO2 trap material and/or a mineral binder material within the gasifier. The process optimally achieves over 90% carbon conversion with over 80% yield of methane. The raw gas product can be used directly as fuel. The catalyst can be recovered from the solid purge and recycled to the gasifier and/or the CO2 trap can be regenerated and recycled to the gasifier.

Recovery and regeneration of spent MHD seed material by the formate process

The specification discloses a spent seed recovery and regeneration process for an MHM power plant employing an alkali metal salt seed material such as potassium salt wherein the spent potassium seed in the form of potassium sulfate is collected from the flue gas and reacted with calcium hydroxide and carbon monoxide in an aqueous solution to cause the formation of calcium sulfate and potassium formate. The pH of the solution is adjusted to supress formation of formic acid and to promote precipitation of any dissolved calcium salts. The solution containing potassium formate is then employed to provide the potassium salt in the form of potassium formate or, optionally, by heating the potassium formate under oxidizing conditions to convert the potassium formate to potassium carbonate.

Mild catalytic steam gasification process

The present invention provides an improved alkali metal catalyzed steam gasification process that utilizes a CO2 trap material and/or a mineral binder material within the gasifier. The process optimally achieves over 90% carbon conversion with over 80% yield of methane. The raw gas product can be used directly as fuel. The catalyst can be recovered from the solid purge and recycled to the gasifier and/or the CO2 trap can be regenerated and recycled to the gasifier.

Desulfurization process

The specification discloses a desulfurization process for use in a fossel fuel combustion process involving the generation of a flue gas product containing sulfur oxides and halogen compounds wherein an alkali metal compound is contacted with the gas resulting in the removal of sulfur oxides from the gas and formation of a water-soluble residue comprising alkali metal sulfates and alkali metal halides, which residue is collected from the gas before the gas is released to the environment. The process is adapted to recover the alkali metal ions from the collected residue for use in supplying the alkali metal ions that are contacted with the gas and for limiting the presence co-collected halogen ions within the recovered alkali metal ions. The process comprises dissolving the collected residue in water to form an aqueous solution thereof having a pH of less than about 8 so that sulfate ions, halogen ions and alkali metal ions are present in the solution. Thereafter, the solution is contacted with a weak base anion-exchange resin having bicarbonate groups associated therewith that exchange with sulfate and halogen ions in the solution so that the sulfate and halogen ions become associated with the resin and the bicarbonate groups become associated with the alkali metal ions in the solution. As a result, the alkali metal ions are separated from the sulfate ions and halogen ions for use in supplying the alkali metal compound that is contacted with the gas.

Catalytic steam gasification process with recovery and recycle of alkali metal compounds

A high efficiency gasification process for converting carbonaceous solids to methane and apparatus for its practice are described. The process includes reacting steam and carbonaceous solids comprising ash in the presence of alkali metal catalyst in a gasification reactor to produce combustible gases and char particles comprising ash and alkali metal catalyst constituents, treating a stream of such char particles in an alkali metal catalyst recovery system to recover the catalyst constituents as alkali metal compounds, and recycling such recovered compounds. Within the alkali metal catalyst recovery system the process includes quenching the stream of char particles with water whereby such particles are cooled and fractured, dissolving soluble alkali metal catalyst constituents from the fractured solids to form a first alkali metal catalyst solution and washed solids, optionally reacting the washed solids in alkaline solution to form a second alkali metal catalyst solution, upgrading said first and optional second alkali solution to recover the alkali metal catalyst constituents as said alkali metal compounds.

Catalytic steam gasification process with recovery and recycle of alkali metal compounds

A high efficiency gasification process for converting carbonaceous solids to methane and apparatus for its practice are described. The process includes reacting steam and carbonaceous solids comprising ash in the presence of alkali metal catalyst in a gasification reactor to produce combustible gases and char particles comprising ash and alkali metal catalyst constituents, treating a stream of such char particles in an alkali metal catalyst recovery system to recover the catalyst constituents as alkali metal compounds, and recycling such recovered compounds. Within the alkali metal catalyst recovery system the process includes quenching the stream of char particles with water whereby such particles are cooled and fractured, dissolving soluble alkali metal catalyst constituents from the fractured solids to form a first alkali metal catalyst solution and washed solids, optionally reacting the washed solids in alkaline solution to form a second alkali metal catalyst solution, upgrading said first and optional second alkali solution to recover the alkali metal catalyst constituents as said alkali metal compounds.

Catalytic steam gasification process with recovery and recycle of alkali metal compounds

A high efficiency gasification process for converting carbonaceous solids to methane and apparatus for its practice are described. The process includes reacting steam and carbonaceous solids comprising ash in the presence of alkali metal catalyst in a gasification reactor to produce combustible gases and char particles comprising ash and alkali metal catalyst constituents, treating a stream of such char particles in an alkali metal catalyst recovery system to recover the catalyst constituents as alkali metal compounds, and recycling such recovered compounds. Within the alkali metal catalyst recovery system the process includes quenching the stream of char particles with water whereby such particles are cooled and fractured, dissolving soluble alkali metal catalyst constituents from the fractured solids to form a first alkali metal catalyst solution and washed solids, optionally reacting the washed solids in alkaline solution to form a second alkali metal catalyst solution, upgrading said first and optional second alkali solution to recover the alkali metal catalyst constituents as said alkali metal compounds.

Catalytic steam gasification process with recovery and recycle of alkali metal compounds

Catalytic steam gasification process with recovery and recycle of alkali metal compounds

Catalytic steam gasification process with recovery and recycle of alkali metal compounds

Catalytic steam gasification process with recovery and recycle of alkali metal compounds

A high efficiency gasification process for converting carbonaceous solids to methane and apparatus for its practice are described. The process includes reacting steam and carbonaceous solids comprising ash in the presence of alkali metal catalyst in a gasification reactor to produce combustible gases and char particles comprising ash and alkali metal catalyst constituents, treating a stream of such char particles in an alkali metal catalyst recovery system to recover the catalyst constituents as alkali metal compounds, and recycling such recovered compounds. Within the alkali metal catalyst recovery system the process includes quenching the stream of char particles with water whereby such particles are cooled and fractured, dissolving soluble alkali metal catalyst constituents from the fractured solids to form a first alkali metal catalyst solution and washed solids, optionally reacting the washed solids in alkaline solution to form a second alkali metal catalyst solution, upgrading said first and optional second alkali solution to recover the alkali metal catalyst constituents as said alkali metal compounds.

Sustained release dosage forms for a jak1 inhibitor.

La presente invención se refiere a formas de dosificación de liberación prolongada que comprenden {1-{1[3-fluoro-2-(trifluorome til)isonicotinoil]piperidin-4-il}-3-[4-(7H-pirrolo[2,3-d]pirimidi n-4-il)-1H-pirazol-1-il]azetidin-3-il}acetonitrilo o una sal farmacéuticamente aceptable de este y dosis y métodos relacionadas con estas.

Non-aqueous solution of plant growth regulator(s) and polar and/or semi-polar organic solvent(s)

The present invention generally relates to non-aqueous solutions of plant growth regulator(s) and polar and/or semi-polar organic solvent (s), methods for making said non-aqueous solution, and methods for improving the growth and crop productivity of plants using said non-aqueous solution. The present invention is directed to a non-aqueous solution of 1 ) at least one plant growth regulator and 2) at least one polar organic solvent and/or at least one semi-polar organic solvent. The present invention further includes methods for making said non-aqueous solution, and methods for improving the growth and crop productivity of plants using said non-aqueous solution.

Blends of poly aryl ether ketones and polyetherimide sulfones

Pulsatile once-a-day-delivery systems for minocycline

Pharmaceutical delivery systems containing 7-dimethyl 6-deoxy 6-demethyltetracycline or a non-toxic acid addition salt thereof comprising mixtures of a minor proportion of slow-release blended polymer coated spherical granules adapted to release part of the minocycline in a medium having a pH of below 3.9 and the rest in the range of from about 4.0 to about 7.5 and a major proportion of coated or uncoated quick-release granules adapted to release minocycline in a medium having a pH of lass than about 3.9 and oral dosage unit form capsules containing the above are provided. These systems and formulations provide enhanced therapeutic blood levels of minocycline for at least about 24 hours when administered to a subject only once-a-day, regardless of whether the patient is fed or fasted. Methods for the preparation of the systems and formulations are provided as well.

Process for the preparation of 3-haloalkylpyrazoles

A process for the preparation of a compound of formula I: (see formula I) wherein R1 is C1-C4 haloalkyl; R2 is C1-C6alkyl; and R3 is methyl or ethyl is provided. The process comprises reacting a compound of formula II: (see formula II) with a compound of formula III: (see formula III) in the presence of an amide.

Pharmaceutical preparations for inhibiting tumours associated with prostate adenocarcinoma, stomach and breast cancer

The present invention provides pharmaceutical preparations for inhibiting in vit ro and in vivo cancerous prostate, gastrointestinal and breast tumours. In one embodiment the pharmaceutical prepar ation includes prostatic inhibin peptide which may be administered in an appropriate dosage form, dosage quantity and dosage regimen t o a patient suffering from prostate cancer. In another embodiment the pharmaceutical preparation includes a mixture of prostati c inhibin peptide and a cancer drug which may be administered in an appropriate dosage form, dosage quantity and dosage re gimen to a patient suffering from, for example gastrointestinal cancer. The cancer drug of the latter mixture may be one select ed from the group of drugs including mitomycin, idalubicin, cisplatin, 5-fluorouracil, methotrexate, adriamycin and donomycin.

Pulsatile once-a-day delivery systems for minocycline

Pharmaceutical delivery systems containing 7-dimethyl-6-deoxy-6-demethyltetracycline or a non-toxic said addition salt thereof comprising mixtures or separate administration units of pH sensitive polymer coated spherical granules adapted to release the minocycline in a medium having a pH of in the range of from about 4.0 to about 7.5 and coated or uncoated quick release granules adapted to release minocycline in a medium having a pH of less than about 3.9 or minocycline powder, pH adapted multi-coated compositions and oral dosage unit forms liquids, capsules or tablets containing the above are provided. These systems and formulations provide at least minimum therapeutic blood levels of minocycline for at least about 24 hours when administered to a subject only once-a-day. Methods for the preparation of the systems and formulations are provided as well.

Improved pulsatile once-a-day delivery systems for minocycline

Trash separating apparatus

PROCESS FOR THE PRODUCTION OF COLUMBIO OXIFLUORIDE AND FOR THE PRODUCTION OF COLUMBIO OXIDE

Polyurea coatings containing silane

Una composición de recubrimiento que comprende: (a) un componente con funcionalidad amina que comprende: (i) una resina con funcionalidad amina a base de un éster aspártico; y (ii) una amina primaria bloqueada; y (b) un componente con funcionalidad isocianato que comprende: (i) un poliisocianato que tiene una funcionalidad mayor de 2,0 y un peso de equivalente de isocianato de más de 300; y (ii) un isocianatosilano o un metacriloxi silano. A coating composition comprising: (a) an amine functional component comprising: (i) an amine functional resin based on an aspartic ester; and (ii) a blocked primary amine; and (b) an isocyanate functional component comprising: (i) a polyisocyanate having a functionality greater than 2.0 and an isocyanate equivalent weight of more than 300; and (ii) an isocyanatosilane or a methacryloxy silane.

Motorized racking assembly

A racking assembly (30) for an electrical apparatus (10) is provided. The racking assembly (30) includes a movable carriage assembly (40) and a drive assembly (50). The movable carriage assembly (40) is sized to fit within a housing assembly (12) and is structured to be moved between a first position and a second position. The carriage assembly (40) is further structured to support at least one electrical component (20). The drive assembly (50) includes a motor assembly (60) and a positioning assembly (80). The motor assembly (60) is structured to impart movement to said positioning assembly (80). The motor assembly (60) is coupled to said positioning assembly (80). The positioning assembly (80) is structured to impart movement to said carriage assembly (40) and to move said carriage assembly (40) from said first position to said second position. The positioning assembly (80) is coupled to said carriage assembly (40). In this configuration, the racking assembly (30) is structured to move the carriage assembly (40), and therefore the electrical apparatus (10), between the first and second positions.

Improved pulsatile once-a-day delivery systems for minocycline

Security link management in dynamic networks

A method for setting up and managing secure data/audio/video links with secure key exchanges, authentication and authorization is described. An embodiment of the invention enables establishment of a secure link with limited privileges using the machine identifier of a trusted machine. This is particularly useful if the user of the machine does not have a user identifying information suitable for authentication. Furthermore, the presentation of a default user identifying information by a user advantageously initiates intervention by a system administrator instead of a blanket denial. This decentralized procedure allows new users access to the network without having to physically access a centralized facility to present their credentials. Another embodiment of the invention enables a remote user to connect to a secure network with limited privileges.

Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form

CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS FROM SPHERICAL GRANULES IN TABLETTED ORAL DOSAGE UNIT FORM ABSTRACT OF THE INVENTION A controlled release pharmaceutical composition in oral dosage unit form comprising a tablet comprising a therapeutically effective number of active spherical granules comprising an effective amount of active medicament, a pharmaceutically acceptable normally solid diluent adapted to form a diffusible matrix for the active medicament and an optional pharmaceutically acceptable excipient; and a number of compressible spherical granules comprising a mono- or disaccharide, an optional pharmaceutical acceptable normally solid diluent adapted to form a diffusible matrix, an optional active medicament and/or an optional pharmaceutically acceptable excipient wherein the average comprehensive yield of the compressible spherical granules is less than the average compressible yield of the active spherical granules is provided. A method for the preparation and for the administration of the above defined composition is provided as well.

Pharmaceutical compositions and administrations thereof

The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.(Formula I), (Formula II), (Formula III).