VERFAHREN UND VORRICHTUNG FÜR FLUGZEUGSENSOREN- UND BETÄTIGUNGSFEHLERSCHUTZ MITTELS REKONFIGURIERBARER FLUGSTEUERUNGSRICHTLINIEN

Ein rekonfigurierbares Flugkontrollsystem zum Rekonfigurieren der Flugkontrolle eines Luftfahrzeugs während eines Ausfalls, wobei das Luftfahrzeug Flugkontrollaktuatoren und -sensoren umfasst und das rekonfigurierbare Flugkontrollsystem Folgendes umfasst: ein software-implementiertes Kontrollgesetz ausgebildet zum automatischen Senden von Flugkontrolldaten zu einer Mischungs/Zuordnungsmatrix; ein Rekonfigurationsverwaltungswerkzeug, ausgebildet zum Kommunizieren mit der Mischungs/Zuordnungsmatrix zum sicheren Überfragen der Zuständigkeit eines ausgefallenen Aktuators an einen Ersatzaktuator; und ein Sensorverwaltungswerkzeug zum Bereitstellen einer Eingabe für das Rekonfigurationsverwaltungswerkzeug, um jegliche Übergangsbedingungen zu glätten, welche während der Rekonfiguration auftreten.

Compound differential thread systems

A compound differentially threaded element engages two or more longitudinally severed segments of a mating threaded element to provide differential linear motion. Different thread types may include pitch, thread starts, handedness or thread-form. Combinations of differential threads may be selected to enable fine or coarse linear motion without correspondingly fine or coarse thread pitches.

Battery comprising electrode with laser-sintered material and shingle face-to-face overlaps within end plate

Instant invention comprises in a preferred embodiment, a set of electrode extensions within an end plate of a cylindrical battery, said set comprising a plurality of groups, each group comprising compactly assembled electrode extensions comprising face-to-face shingle overlaps within each group, said overlaps comprising in said each group a central extension of said each group, said central extension having a first face and an opposite face, said first face comprising face-to-face shingle overlap with one face each of two adjacent extensions of said group, and said opposite face of the central extension having at least one of a face-to-face shingle overlap comprising one face of one other adjacent extension and face-to-face shingle overlap comprising one face each of two other adjacent extensions.

Method and system for preserving cognitive capacity during aging

The present invention comprises compositions having a.) at least one acetyltransferase EP300 inhibitor-substance, such as chemically pure spermidine or spermidine-rich wheat germ extract, and optionally b.) at least one nrf2 activator-substance, such as cocoa flavonoids. In use, a user typically adds said compositions to food during the day, and then consumes compositions with food. Typically, such additions are scheduled to occur regularly on consecutive days, for months and over years, such as edible bits of sprinkles-configuration added to meals and snacks, or other configurations as herein disclosed. Such compositions are typically consumed by user in divided doses each day, as disclosed herein.

Flexible Armature Plate for an Electro-Magnetic Overrunning Clutch

An electro-magnetic coil assembly mounted to a clutch assembly, the electro-magnetic coil assembly including a coil mounted within an annular coil housing and a flexible armature plate. The coil assembly adapted to generate an electromagnetic field between the coil and the armature plate for attracting the armature plate to the coil assembly. The flexible armature plate includes an annular plate with an outer edge and an inner edge, the outer edge defining an outer periphery, the inner edge defining an inner periphery. Tangs spaced about the inner periphery extending radially inward from the inner edge. Inner notches spaced about the inner periphery of the annular plate and extending radially outward to a point at least halfway in the radial direction between the inner edge and the outer edge. Outer notches spaced about the outer periphery between and extending radially inward to a point at least halfway in the radial direction between the outer edge and the inner edge.

Methods for chromium catalyst activation using oxygen-enriched fluidization gas

Processes for producing an activated chromium catalyst are disclosed, and these processes comprise contacting a supported chromium catalyst with a gas stream containing from 25-60 vol % oxygen at a peak activation temperature of 550-900° C. to produce the activated chromium catalyst. The linear velocity of the gas stream is 0.18-0.4 ft/sec, and the oxygen linear velocity of the gas stream is 0.05-0.15 ft/sec. The resultant activated chromium catalyst and an optional co-catalyst can be contacted with an olefin monomer and an optional olefin comonomer in a polymerization reactor system under polymerization conditions to produce an olefin polymer.

Method and apparatus to collect cores from golf green

A method to collect soil cores from a green comprises the steps of providing a soil core collector, extracting soil cores from a green, allowing the cores to dry for at least fifteen minutes, and utilizing the core collector to gather the cores from the green.

Energy efficient polyolefin process

A manufacturing system for producing polyolefin includes a polymerization reactor, a flash chamber, and a purge column. In certain embodiments, the purge column may receive a solids stream directly from the flash chamber. Further, the purge column may function as a feed tank for an extruder within an extrusion/loadout system. According to certain embodiments, the manufacturing system may be configured to consume less than 445 kilowatt-hours of energy per metric ton of polyolefin produced based on consumption of electricity, steam, and fuel gas.

Rapid deploy method and system for protecting a building against damage by an approaching wildfire

A rapid deploy method and system fir protecting a building against damage by an approaching wildfire includes rapidly deploying a durable ember-resistant cover over at least a portion of the building as wildfire approaches, and optionally deploying a temporary fire-suppression wall, configured to stop or deflect or slow winds, and reduce heat and repel embers of an approaching wildlife. Advantageously, the durable fire-suppression wall, optionally built with a number of mobile wall sub-units, is designed to be transported by a single user. Each mobile wall sub-unit optionally includes a vertical wall section and a flared base section designed to provide a solid base and hold an internal tank configured to store a fire-suppression substance. A spray assembly positioned on each sub-unit is designed to spray the fire-suppression substance. The over-the-building cover, optionally comprised of stainless-steel wire mesh fabric, may be placed over the building without contemporaneous wall deployment if exigent circumstances.

Low-lectin diet system and method for improving health

A low-lectin diet system comprising a terminology-marked food package configured for enabling coordinated efficiency in healthful food selection during shopping enabling a shopper to quickly identify said package as containing low lectin-antigenicity food contents, and wherein said food package is visibly marked externally with coordinated terminology validly designating food contents as of relatively low lectin-antigenicity.

Methods for chromium catalyst activation using oxygen-enriched fluidization gas

Processes for producing an activated chromium catalyst are disclosed, and these processes comprise contacting a supported chromium catalyst with a gas stream containing from 25-60 vol % oxygen at a peak activation temperature of 550-900 °C to produce the activated chromium catalyst. The linear velocity of the gas stream is 0.18-0.4 ft/sec, and the oxygen linear velocity of the gas stream is 0.05-0.15 ft/sec. The resultant activated chromium catalyst and an optional co-catalyst can be contacted with an olefin monomer and an optional olefin comonomer in a polymerization reactor system under polymerization conditions to produce an olefin polymer.

Energy efficient polyolefin process

A manufacturing system for producing polyolefin includes a polymerization reactor, a flash chamber, and a purge column. In certain embodiments, the purge column may receive a solids stream directly from the flash chamber. Further, the purge column may function as a feed tank for an extruder within an extrusion/loadout system. According to certain embodiments, the manufacturing system may be configured to consume less than 445 kilowatt-hours of energy per metric ton of polyolefin produced based on consumption of electricity, steam, and fuel gas.

Energy efficient polyolefin process

A manufacturing system for producing polyolefin includes a polymerization reactor, a flash chamber, and a purge column. In certain embodiments, the purge column may receive a solids stream directly from the flash chamber. Further, the purge column may function as a feed tank for an extruder within an extrusion/loadout system. According to certain embodiments, the manufacturing system may be configured to consume less than 445 kilowatt-hours of energy per metric ton of polyolefin produced based on consumption of electricity, steam, and fuel gas.

Energy efficient polyolefin process

A manufacturing system for producing polyolefin includes a polymerization reactor, a flash chamber, and a purge column. In certain embodiments, the purge column may receive a solids stream directly from the flash chamber. Further, the purge column may function as a feed tank for an extruder within an extrusion/loadout system. According to certain embodiments, the manufacturing system may be configured to consume less than 445 kilowatt-hours of energy per metric ton of polyolefin produced based on consumption of electricity, steam, and fuel gas.

Energy efficient polyolefin process

A manufacturing system for producing polyolefin includes a polymerization reactor, a flash chamber, and a purge column. In certain embodiments, the purge column may receive a solids stream directly from the flash chamber. Further, the purge column may function as a feed tank for an extruder within an extrusion/loadout system. According to certain embodiments, the manufacturing system may be configured to consume less than 445 kilowatt-hours of energy per metric ton of polyolefin produced based on consumption of electricity, steam, and fuel gas.

Energy efficient polyolefin process

A manufacturing process for producing polyolefin, having a feed system, a reactor system including at least one polymerization reactor, a diluent/monomer recovery system, a fractionation system, and an extrusion/loadout system having an extruder. The manufacturing process is configured to consume less than 325 kilowatt-hours of electricity per metric ton of polyolefin produced.

Energy efficient polyolefin process

A manufacturing system for producing polyolefin includes a polymerization reactor, a flash chamber, and a purge column. In certain embodiments, the purge column may receive a solids stream directly from the flash chamber. Further, the purge column may function as a feed tank for an extruder within an extrusion/loadout system. According to certain embodiments, the manufacturing system may be configured to consume less than 445 kilowatt-hours of energy per metric ton of polyolefin produced based on consumption of electricity, steam, and fuel gas.

Energy efficient polyolefin process

A manufacturing process for producing polyolefin, having a feed system, a reactor system including at least one polymerization reactor, a diluent/monomer recovery system, a fractionation system, and an extrusion/loadout system having an extruder. The manufacturing process is configured to consume less than 325 kilowatt-hours of electricity per metric ton of polyolefin produced.

Large catalyst activator

A catalyst activator vessel for heat conditioning a catalyst is disclosed. The activator vessel includes inner and outer vessels, a perforated, normally generally horizontal grid plate within the inner vessel, and a fluid path extending through the grid plate within the vessel. The inner vessel can have an inside diameter of at least 50 inches (1.27 m). The space between the inner and outer vessels defines a flue. The perforated grid plate within the inner vessel can have an upper surface perforated with a pattern of overlapping, generally conical depressions and a lower surface, optionally overlapping by at least 17%. The fluid path extends upwardly through the perforated grid plate and is a conduit along which a fluid flows through the grid plate. The fluid will fluidize a particulate material, such as a catalyst, disposed above the grid plate in the inner vessel.

Catalyst pretreatment and feeding system for polypropylene production

A process and system for pre-polymerizing propylene are disclosed. A first catalyst suspension is formed by mixing catalyst particles with a hydrocarbon that is a saturated hydrocarbon or propylene. Various other catalyst components are added to the first catalyst suspension, and the first catalyst suspension is then pre-polymerized under pre-polymerization conditions to form a pre-polymerized catalyst suspension that is introduced to a polymerization reactor or a storage tank. The saturated hydrocarbon can be propane, mixed butanes, or mixture thereof.

System and method for rapid dump tank heating

A method of operating a dump tank of a polymer production process by transferring all or a portion of a content of a polymerization reactor into the dump tank, wherein the reactor contents comprise solid polymer, and liquid and gaseous non-product components, and removing at least a portion of the liquid and gaseous non-product components from the dump tank by: reducing a pressure of the dump tank, subjecting the solid polymer to a first cleaning stage comprising heating the solid polymer by introducing a first heated treatment gas into the dump tank, and subjecting the solid polymer to a second cleaning stage comprising purging the solid polymer by introducing a second heated treatment gas into the dump tank.

Dendritic molecular intracellular transporters and methods of making and using same

In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to compounds comprising the structure: and at least one guanidinium residue, wherein m is zero or a positive integer. Also disclosed are methods of preparing the disclosed compounds. Also disclosed are methods of intracellular delivery comprising administering the disclosed compounds and compositions to a subject. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of one or more compounds or compositions of the invention and a pharmaceutically acceptable carrier. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Continuous withdrawal from high solids slurry polymerization

An improved polymerization process includes withdrawing a portion of a fluid slurry through a plurality of active continuous take off mechanisms, monitoring the pressure of feed material fed to the reactor, and adjusting the continuous take off mechanisms in response to the monitored feed line pressure.

Outside frame for side-opening cabin-type tents

Process and apparatus for recovering diluent, monomer, and comonomer from a polymerization reactor effluent

A process and apparatus are provided for recovering diluent, unreacted monomer, and unreacted comonomer from a polymerization reactor effluent. The comonomer has a boiling point higher than the boiling point of the monomer and the diluent has a boiling point between the boiling points of the monomer and comonomer. The process and apparatus employ at least one flash tank, a first fractionation stage including a first column and operating at a first fractionation pressure, and a second fraction stage including a second column and operating at a higher second fractionation pressure. Comonomer is withdrawn from the first column as a fractionation product, and overhead vapor containing diluent and monomer is substantially condensed to yield a substantially condensed overhead stream. Liquid and vapor from the stream are separated in an accumulator. Vapor and liquid from the accumulator are compressed and pumped, respectively, for delivery to the second fractionation stage at approximately the second fractionation pressure. The pumped liquid is a major portion by weight of the total flow of pumped liquid and compressed vapor to the second fractionation stage. Diluent and monomer are withdrawn from the second column as fractionation products.

Energy efficient polyolefin process

A manufacturing process for producing polyolefin, having a feed system, a reactor system including a polymerization reactor, a diluent/monomer recovery system, a fractionation system, and an extrusion/loadout system having an extruder. The manufacturing process is configured to consume less than about 445 kilowatt-hours of electricity per metric ton of polyolefin produced.

Loop Slurry Reactor Cooling Processes and Systems

Disclosed are systems and processes for distributing reactor coolant flow to the cooling jackets of a loop slurry reactor, where the reactor coolant is used to control the temperature of the loop slurry reactor in olefin polymerization. Also disclosed are systems and processes for controlling the temperature of the reactor coolant that is used for cooling olefin polymerization reactors, which can be used in combination with traditional coolant distribution regimes and in combination with the coolant distribution systems and processes that are disclosed herein.

Continuous withdrawal from high solids slurry polymerization

An improved polymerization process includes withdrawing a portion of a fluid slurry through a plurality of active continuous take off mechanisms, monitoring the pressure of feed material fed to the reactor, and adjusting the continuous take off mechanisms in response to the monitored feed line pressure.

System and Method for Deinventory of Polymerization Reactor

A flash chamber sized to receive the effluent discharged from a polyolefin reactor during normal operation of the reactor and during a reactor dump, advantageously eliminating a reactor dump tank or alternate flash tank from the equipment outlay of a polyolefin manufacturing process. The flash chamber is sized to hold at least the polyolefin solids discharged from the reactor. A condenser fluidically coupled to an overhead portion of the flash chamber is sized to condense the flow rate of vaporized hydrocarbon (e.g., diluent, monomer, etc.) discharged overhead from the flash chamber during normal operation and during the reactor dump.

System and method for deinventory of polymerization reactor

A flash chamber sized to receive the effluent discharged from a polyolefin reactor during normal operation of the reactor and during a reactor dump, advantageously eliminating a reactor dump tank or alternate flash tank from the equipment outlay of a polyolefin manufacturing process. The flash chamber is sized to hold at least the polyolefin solids discharged from the reactor. A condenser fluidically coupled to an overhead portion of the flash chamber is sized to condense the flow rate of vaporized hydrocarbon (e.g., diluent, monomer, etc.) discharged overhead from the flash chamber during normal operation and during the reactor dump.

Continuous withdrawal from high solids slurry polymerization

An improved polymerization process includes withdrawing a portion of a fluid slurry through a plurality of active continuous take off mechanisms, monitoring the pressure of feed material fed to the reactor, and adjusting the continuous take off mechanisms in response to the monitored feed line pressure.

Continuous withdrawal from high solids slurry polymerization

An improved polymerization process includes withdrawing a portion of a fluid slurry through a plurality of active continuous take off mechanisms, monitoring the pressure of feed material fed to the reactor, and adjusting the continuous take off mechanisms in response to the monitored feed line pressure.

Energy efficient polyolefin producction process

A manufacturing process and system for producing polyolefin, having a feed system, a reactor system including a polymerization reactor, a diluent/monomer recovery system, a fractionation system, and an extrusion/loadout system having an extruder. The manufacturing process is configured to consume less than 325 kilowatt-hours of electricity per metric ton of polyolefin produced.

Conjugated lipomers and uses thereof

The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as "conjugated lipomers" or "lipomers") containing one or more groups of the formula (iii): wherein R 3 and R 4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.

Temperature controlling system for olefin polymerization reactors

Methods for controlling the temperature of an olefin polymerization reactor (e.g., a polyethylene reactor) system are disclosed herein. The olefin polymerization reactor system includes a polymerization reactor and a cooling jacket in thermal contact with the reactor. An aqueous froth is present in the jacket, and the pressure therein is maintained below atmospheric pressure. Control of the pressure in the jacket controls the boiling temperature of the jacket fluid, and thus, controls the rate of heat transfer from the reactor to the fluid in the jacket. This provides an efficient and simple means for controlling the reactor temperature.

System and method for deinventory of polymerization reactor

A flash chamber sized to receive the effluent discharged from a polyolefin reactor during normal operation of the reactor and during a reactor dump, advantageously eliminating a reactor dump tank or alternate flash tank from the equipment outlay of a polyolefin manufacturing process. The flash chamber is sized to hold at least the polyolefin solids discharged from the reactor. A condenser fluidically coupled to an overhead portion of the flash chamber is sized to condense the flow rate of vaporized hydrocarbon (e.g., diluent, monomer, etc.) discharged overhead from the flash chamber during normal operation and during the reactor dump.

Method for deinventory of polymerization reactor

Guidewire with movable core and external tubular safety cover

A movable core guidewire assembly comprising a wire wound cylindrical casing having a distal closed end and a proximal open end, a resilient movable core wire extending inside the cylindrical casing between its proximal and distal ends, and a plastic safety cover coextensive with and surrounding the wire wound cylindrical casing. The plastic safety cover functions to retain fragments of a broken guidewire, replacing the interior safety wire used in prior art guidewire assemblies. Therefore, the movable core wire can utilize all the space inside the cylindrical casing to maximize the ability of medical personnel to manipulate the guidewire assembly inside the body. A specific procedure for forming a closed distal tip of the guidewire assembly from an initially open ended casing and safety cover is also disclosed.

Apparatus and method for determining refrigerant charge level

A method and apparatus for non-invasively determining a charge level of a refrigerant in a vapor-compression cycle system. The method and apparatus monitor the system while the system is operated to ascertain that the system is operating at approximately steady-state. The superheat and the subcooling of the system are then determined at the suction line and at the liquid line, respectively, and the refrigerant charge level is calculated based on the determined subcooling, the determined superheat, and rated operating conditions of the system, including rated refrigerant charge level, rated liquid line subcooling, and rated suction line superheat.

Energy efficient polyolefin process

A manufacturing process for producing polyolefin, having a feed system, a reactor system including a polymerization reactor, a diluent/monomer recovery system, a fractionation system, and an extrusion/loadout system having an extruder. The manufacturing process is configured to consume less than about 445 kilowatt-hours of electricity per metric ton of polyolefin produced.

Polyolefin production processes

Un sistema de fabricación para producir una poliolefina, que comprende: - un sistema de alimentación que comprende un caudalímetro de masa configurado para medir el caudal de una alimentación de monómero al reactor de polimerización, - un sistema de reactor de poliolefina que tiene un reactor de polimerización, en el que el reactor de polimerización comprende una salida continua, - un sistema de recuperación de diluyente/monómero configurado para procesar el efluente descargado del reactor de polimerización, en el que el efluente comprende partículas de poliolefina y diluyente y en el que el sistema de recuperación de diluyente/monómero está configurado para facilitar el reciclado directo de por lo menos el 80% en peso de diluyente recuperado en el sistema de recuperación de diluyente/monómero al reactor de polimerización sin fraccionamiento, - un sistema de fraccionamiento configurado para procesar una porción del diluyente, y - un sistema de extrusión/descarga que tiene una extrusora, en el que el sistema de fabricación que está configurado para consumir menos de 144 kilogramos de vapor de agua por tonelada métrica de poliolefina producida. A manufacturing system for producing a polyolefin, comprising: - a feed system comprising a mass flowmeter configured to measure the flow rate of a monomer feed to the polymerization reactor, - a polyolefin reactor system having a reactor polymerization, in which the polymerization reactor comprises a continuous outlet, - a diluent / monomer recovery system configured to process the effluent discharged from the polymerization reactor, in which the effluent comprises polyolefin particles and diluent and in which the diluent / monomer recovery system is configured to facilitate direct recycling of at least 80% by weight of diluent recovered in the diluent / monomer recovery system to the polymerization reactor without fractionation, - a fractionation system configured to process a portion of the diluent, and - an extrusion / ...

Energy efficient polyolefin process

Energy efficient polyolefin process

A manufacturing process for producing polyolefin, having a feed system, a reactor system including at least one polymerization reactor, a diluent/monomer recovery system, a fractionation system, and an extrusion/loadout system having an extruder. The manufacturing process is configured to consume less than 325 kilowatt-hours of electricity per metric ton of polyolefin produced.

Energy efficient polyolefin process

A manufacturing process for producing polyolefin, having a feed system, a reactor system including a polymerization reactor, a diluent/monomer recovery system, a fractionation system, and an extrusion/loadout system having an extruder. The manufacturing process is configured to consume less than about 445 kilowatt-hours of electricity per metric ton of polyolefin produced.

Energy efficient polyolefin process

A manufacturing process for producing polyolefin, having a feed system, a reactor system including a polymerization reactor, a diluent/monomer recovery system, a fractionation system, and an extrusion/loadout system having an extruder. The manufacturing process is configured to consume less than about 445 kilowatt-hours of electricity per metric ton of polyolefin produced.

System and method for deinventory of polymerization reactor

A flash chamber sized to receive the effluent discharged from a polyolefin reactor during normal operation of the reactor and during a reactor dump, advantageously eliminating a reactor dump tank or alternate flash tank from the equipment outlay of a polyolefin manufacturing process. The flash chamber is sized to hold at least the polyolefin solids discharged from the reactor. A condenser fluidically coupled to an overhead portion of the flash chamber is sized to condense the flow rate of vaporized hydrocarbon (e.g., diluent, monomer, etc.) discharged overhead from the flash chamber during normal operation and during the reactor dump.

Continuous withdrawal from high solids slurry polymerization

An improved polymerization process includes withdrawing a portion of a fluid slurry through a plurality of active continuous take off mechanisms, monitoring the pressure of feed material fed to the reactor, and adjusting the continuous take off mechanisms in response to the monitored feed line pressure.

System and method for rapid dump tank heating

A method of operating a dump tank of a polymer production process by transferring all or a portion of a content of a polymerization reactor into the dump tank, wherein the reactor contents comprise solid polymer, and liquid and gaseous non-product components, and removing at least a portion of the liquid and gaseous non-product components from the dump tank by: reducing a pressure of the dump tank, subjecting the solid polymer to a first cleaning stage comprising heating the solid polymer by introducing a first heated treatment gas into the dump tank, and subjecting the solid polymer to a second cleaning stage comprising purging the solid polymer by introducing a second heated treatment gas into the dump tank.

Method, apparatus and system for verification of human medical data

A method and apparatus for collecting medical data from a test subject while optionally preserving anonymity for the test subject. The method includes steps of collecting a sample from the test subject and taking biometric data from the test subject. The biometric data permit a high order of probability of correlation of the test subject with the sample and with test results derived from the sample. The method optionally further includes a step of providing the test subject with a unique correlating code also for permitting unique correlation of the test subject with the sample and with test results derived from the sample, and further desirably includes a step of labeling the sample with information including the biometric data.

System including a biological sample treatment chamber

The present disclosure is directed to specimen processing assemblies including (a) a lower plate (10), (b) an upper plate (30) complementary to the lower plate, and (c) a chamber formed therefrom. In some embodiments, the formed chamber is adapted to perform an unmasking operation, e.g. antigen retrieval and/or target retrieval. In some embodiments, the specimen processing assemblies are configured to maintain a specimen-bearing substrate (15) horizontal during all processing steps. The present disclosure is also directed to systems including one or more independently operable specimen processing assemblies.

Cyanoperfluoroether acid fluorides and copolymers derived therefrom

Disclosed herein are cyanoperfluoro(vinyl ethers), intermediate acid fluorides; a process for preparing the acid fluorides, and a process for preparing the vinyl ethers from acid fluoride and an alkali-metal carbonate. Also disclosed are copolymers incorporating units derived from the vinyl ethers as crosslinking constituents therein.

Cyanoperfluoroether acid fluorides and their preparation

Disclosed herein are cyanoperfluoro(vinyl ethers), intermediate acid fluorides; a process for preparing the acid fluorides, and a process for preparing the vinyl ethers from acid fluoride and an alkali-metal carbonate. Also disclosed are copolymers incorporating units derived from the vinyl ethers as crosslinking constituents therein.

Method and apparatus for registering a pre-printed web on a printing press

A preprinted web having a plurality of first repeating images is reprinted with a plurality of second repeating images which are in register with the first images. A register mark is printed on the web for each of the first images. When the web is reprinted, the positions of the register marks are sensed and compared with the positions of the second images, and the unwind tension of the web is adjusted to maintain the relative positions substantially constant.

Protected guide RNAS (PGRNAS)

The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems, wherein the guide sequence is modified by secondary structure to increase the specificity of the CRISPR-Cas system and whereby the secondary structure can protect against exonuclease activity and allow for 5′ additions to the guide sequence.

Communicating in a network that includes a medium having varying transmission characteristics

A method and corresponding system for operating in a network in which stations communicate over a shared medium are presented. The shared medium has at least one varying channel characteristic that varies approximately periodically. The method includes providing repeated beacon transmissions from a coordinator station for coordinating transmissions among a plurality of the stations, wherein at least some beacon transmissions are synchronized to the varying channel characteristic; and transmitting from a first station to at least one receiving station during a time slot determined based on at least one of the beacon transmissions received by the first station from the coordinator station.

Time synchronization in a network

A method and corresponding system for communicating between stations in a network is presented. The method includes providing repeated beacon transmissions from a coordinator station for coordinating transmissions among the stations; transmitting a signal from a first station and receiving the signal at a second station; and performing one or both of: generating the signal based on a local clock at the first station and time adjustment information in a beacon transmission received by the first station, and sampling the signal at sample times based on a local clock at the second station and time adjustment information in a beacon transmission received by the second station.

Compounds for inhibiting β-amyloid peptide release and/or its synthesis

Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis.

Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis

Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Implantable endocardial lead assembly having a stent

Various endocardial lead assemblies are disclosed that may be particularly useful for placement within the coronary sinus. The lead assemblies may have open ends or closed ends. Lead assemblies having closed ends may be implanted using conventional implantation procedures. Lead assemblies have open ends may be implanted by first locating a stylet within the patient's body and, then, inserting the lead into the patient's body along the stylet. Each disclosed lead assembly uses one or more stents which expand to contact the inner surface of a body vessel once the lead has been properly positioned. Thus, the stents fix the lead at the desired location. Additionally, the stents may be used as electrodes for pacing and/or sensing.

Cardiac lead with shape-memory structure

A cardiac stimulator lead is provided that includes a lead body that has a connector for coupling to a cardiac stimulator and a flexible insulating sleeve that has a first outer diameter. An electrode is coupled to the insulating sleeve. A conductor wire is coupled between the connector and the electrode. An annular seat is coupled to the lead body and is composed of a thermally-sensitive shape-memory polymeric material whereby the seal is deformable in situ from a temporary shape with a second outer diameter to a permanent shape with a third outer diameter that is greater than the second outer diameter. A shape-memory polymeric suture sleeve may be included that can tightly clamp the lead sleeve in situ.

Systems and methods for network channel allocation

Embodiments of the present invention comprise systems and methods for network connection setup and bandwidth allocation comprising negotiable and non-negotiable modulation allocation procedures.

Systems and methods for network channel characteristic measurement and network management

Embodiments of the present invention comprise systems and methods for detecting and applying network channel characteristic measurements.

Systems and methods for dynamic network channel modification

Embodiments of the present invention comprise methods and systems for establishment and modification of network allocation parameters.

Conjugated lipomers and uses thereof

The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R 3 and R 4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.

Conjugated lipomers and uses thereof

The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R 3 and R 4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.

Conjugated lipomers and uses thereof

The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R 3 and R 4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.

Surgical stapler

Methods and device for closing a puncture wound in a liquid carrying vessel are provided. In one exemplary embodiment, a surgical stapler is provided having a locator tube width an inflatable member formed thereon and adapted to be positioned within a liquid carrying vessel adjacent a puncture wound, and a staple applying apparatus that is slidably disposed on a portion of the locator tube and that is adapted to apply a surgical staple to seal a puncture wound in a liquid carrying vessel. <Figure 1>

N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for use

Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Escorted and functionalized guides for crispr-cas systems

The present invention generally relates to CRISPR systems or complexes, such as those with an escorted guide RNA.

Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Footwear and its method of construction

Footwear and a method for its construction including the following features is provided. An upper which defines a volume for receiving a wearer's foot. A midsole which has an inner surface, an outer surface opposite to the inner surface, and an upstanding sidewall around its periphery. Stitching, which attaches the upper to the midsole along a peripheral portion of the upper and the sidewall of the midsole. An outsole, which has a walking surface and an attachment surface opposite to the walking surface. The outer surface of the midsole adhered to the opposed surface of the outsole.

Electrodeless lamp with bulb rotation

An electrodeless lamp bulb (12) is rotated at sufficient rate to obviate isolated discharges. A coaxially excited electrodeless lamp bulb (12) is rotated in such manner that different regions of the bulb are near the high field region caused by the inner coaxial conductor, thus preventing arc attachment from occurring. An electrodeless lamp bulb (12) is rotated at a high speed sufficient to improve lamp efficiency and reduce cooling requirement. An electrodeless lamp bulb (12) is provided with wall of reduced thickness at the area of the bulb (12) where it is desired to condense the fill upon turning off the power, thus providing for quicker starting.

Process for the production of high purity magnesium alloys and alloy thus obtained.

Process for producing magnesium alloys of high purity and alloy thus obtained.

A method for producing a high purity magnesium alloy is disclosed in which the alloying components are introduced in the molten state into molten magnesium. In accordance with the process of the invention, a predetermined amount of primary magnesium is heated and melted in a crucible. Predetermined amounts of desired alloying metals are selected and heated to their melting temperature in a separate crucible. The molten alloying metals are then introduced into the molten magnesium to substantially instantaneously alloy with the molten magnesium in a reaction raising the temperature of the melt. Elemental manganese when first alloyed with other alloying metals prior to its addition to the molten magnesium is found to consistently be more effective in reducing the iron impurity level of the melt to a level below 50 ppm. The introduction of a molten alloy of manganese and one or more rare earth metals into the molten magnesium, reduces a settling out of the rare earth metal from the melt and increases the alloying efficiency for the rare earth metal to greater than 80 %. The efficiency of the process of the invention is substantially increased, the consumption of time and energy is decreased, and the production of magnesium chloride slag and gaseous HCl is avoided.

SOLID STATE LASER ARMING / FIRED DEVICE

L'invention concerne un dispositif d'armement/de mise à feu à laser à l'état solide. Ce dispositif comprend un interrupteur électronique (34/36) pour déclencher l'amorçage d'une matière pyrotechnique (42) en réponse à un signal, des moyens laser (38) connectés électriquement à l'interrupteur électronique pour produire une impulsion laser et une fibre optique (40) dont une extrémité est couplée optiquement aux moyens laser et dont l'autre est insérée dans la matière pyrotechnique (42) de sorte que l'impulsion laser concentre de la chaleur sur l'extrémité insérée de la fibre optique pour amorcer la matière pyrotechnique. Application notamment aux dispositifs d'armement/de mise à feu pour l'activation de charges explosives. A solid state laser arming / firing device is disclosed. This device comprises an electronic switch (34/36) for triggering the ignition of a pyrotechnic material (42) in response to a signal, laser means (38) electrically connected to the electronic switch to produce a laser pulse and a optical fiber (40) one end of which is optically coupled to the laser means and the other of which is inserted into the pyrotechnic material (42) so that the laser pulse concentrates heat on the inserted end of the optical fiber to initiate pyrotechnic material. Application in particular to arming / firing devices for activating explosive charges.

Multi-speed planetary differential

MULTI-SPEED PLANETARY DIFFERENTIAL Abstract A compact planetary differential is provided including first and second planetary sets individually having ring, sun, and carrier elements, a rotary input member, first and second output members individually connected to a preselected first one of the elements of the respective planetary sets, and with preselected second ones of the elements of the respective planetary sets being connected for joint rotation. A multi-speed unit desirably always drives the output members at equal torque levels while imparting multi-speed capability thereto. The multi-speed unit is driven by the input member and drives the remaining third one of the elements of the second planetary set in at least one speed. The multi-speed unit preferably includes a third planetary set, one brake assembly and a clutch assembly, or two brake assemblies connected to pre-selected ones of the ring, sun, and/or carrier elements thereof.

Small cable endocardial lead with exposed guide tube

A lead assembly (10) adapted for endocardial fixation to a human heart is provided. The lead assembly includes a lead body (12) that has a proximal end provided with a connector (16) for electrical connection to a cardiac stimulator (18). The cardiac stimulator may be a pacemaker, a cardioverter/defibrillator, or a sensing instrument. The distal end of the lead body is connected to a tubular electrode housing (22). The lead body (12) consists of a noncoiled conductor cable (24) surrounded by a coextensive insulating sleeve (26). In contrast to conventional leads, the lead body of the present invention does not require coiled conductor wires or an internal lumen. Manipulation of the lead body is via an external guide tube. Lead body diameters of 0.25 mm or smaller are possible.

Mobile foldable bleacher

Two stroke engine braking via cylinder deactivation and late intake valve closing

A method for engine braking on a type III valvetrain diesel engine comprises, on a first downstroke of a reciprocating piston, deactivating a normal intake lift profile on a first intake valve to implement a deactivated intake profile. Before a first upstroke of the reciprocating piston completes, a late intake valve closing lift profile is actuating on a second intake valve and beginning an engine brake lift profile on a first exhaust valve. On a second downstroke of the reciprocating piston, the engine brake lift profile on the first exhaust valve is completing and a normal exhaust lift profile is deactivating on a second exhaust valve to implement a deactivated exhaust profile on the second exhaust valve. Before a second upstroke of the reciprocating piston completes, a second engine brake lift profile is beginning on the first exhaust valve.

Sterile barrier assembly, mounting system, and method for coupling surgical components

A sterile barrier assembly, mounting system, and method for kinematicaliy coupling first and second surgical components together through the sterile barrier assembly so that positioning is repeatable and deterministic.

Actuating mechanism for biopsy needle

A spring-powered actuating device for operating the obturator and the cannula of a biopsy needle, and a cocking device removably attachable to the actuating device. The actuating device has a manually-operated trigger slide which controls separately the release of spring-powered slides for moving the obturator and the cannula so the surgeon determines the time interval between the release of the obturator and the later release of the cannula. The extent to which the trigger slide can be displaced manually is controlled by a manually adjustable safety slide which may be set in a first position to permit the trigger slide to release the slide for the obturator only and in a second position to permit the trigger slide to release the slide for the cannula. The cocking device, when attached to the actuating device, is movable pivotally toward the actuating device by squeezing them together manually and when so moved it retracts the slides for the obturator and the cannula to stress their springs which power them.

Pesticidal compositions and processes related thereto

Continuous withdrawal from high solids slurry polymerization

An improved polymerization process includes withdrawing a portion of a fluid slurry through a plurality of active continuous take off mechanisms, monitoring the pressure of feed material fed to the reactor, and adjusting t he continuous take off mechanisms in response to the monitored feed line pressu re.

Biopsy device

A biopsy device utilizes three components: a housing having an attached cannula, a drill bit/plunger component which is mounted in the housing so that the drill bit portion, having a cutting tip, extends through the cannula, the plunger snugly fitting within the housing, and a rotational energy element which couples with the drill bit/plunger component to enable the impartation of rotational motion to the cutting tip. Both drilling and aspirating action are utilized to retrieve a biopsy sample. In operation, the tissue to be sampled is punctured by a biopsy needle, the cannula of which is connected to the biopsy device. Thereafter, rotational energy is imparted to the drill bit/plunger component, causing tissue to be accumulated on the cutting tip. Once a sufficient amount of tissue has been accumulated, the rotational energy element and plunger/drill bit component are displaced in a proximal direction from the housing to cause the sample to be aspirated into the cannula syringe. The biopsy device is withdrawn from the tissue, and the sample is retrieved by exerting longitudinal pressure in a distal direction on the rotational energy element and, in turn, the drill bit/plunger component.

5HT1F agonists for the treatment of migraine

This invention provides novel 5-HT 1F agonists which are useful for the treatment of migraine and associated disorders.

Multifocal lens

HUMAN NEUTRALIZING MONOCLONAL ANTIBODIES FOR THE SYNCTIAL RESPIRATORY VIRUS.

SE DESCRIBEN ANTICUERPOS MONOCLONALES HUMANOS Y FRAGMENTOS DEL MISMO QUE ENLAZAN Y NEUTRALIZAN LOS SUBGRUPOS A Y B ANTIGENICOS DEL VIRUS SINCITIAL RESPIRATORIO. TAMBIEN SE DESCRIBEN METODOS DE DIAGNOSTICO E INMUNOTERAPEUTICOS DE UTILIZACION DE ANTICUERPOS MONOCLONALES ASI COMO LINEAS CELULARES QUE PRODUCEN LOS ANTICUERPOS MONOCLONALES. HUMAN MONOCLONAL ANTIBODIES AND FRAGMENTS OF THE SAME THAT LINK AND NEUTRALIZE THE ANTIGEN SUBGROUPS A AND B OF THE RESPIRATORY SYNCTIAL VIRUS ARE DESCRIBED. ALSO DESCRIBED METHODS OF DIAGNOSIS AND IMMUNOTHERAPEUTICS FOR THE USE OF MONOCLONAL ANTIBODIES AS WELL AS CELLULAR LINES THAT PRODUCE THE MONOCLONAL ANTIBODIES.

Polycyclic .alpha.-amino-e-caprolactams and related compounds

Disclosed are polycyclic .alpha.-amino--caprolactams and related compounds which are useful as synthetic intermediates in the preparation of inhibitors of .beta.-amyloid peptide release and/or its synthesis.

Human neutralizing monoclonal antibodies to respiratory syncytial virus.

Electrical plug and outlet protector

ABSTRACT OF THE DISCLOSURE An electrical plug and outlet protector that allows for disengagement between an electrical plug and outlet without damage, by application of a lateral force not generally perpendicular to the outlet face, is quickly and easily connectable to the plug and associated power cord, is adaptable to various shape plugs, is inexpensive to manufacture, and is durable.

SOLID STATE LASER FIRE / ARMING DEVICE

Flow-through rotary damper providing compartment selectivity for a multi-compartment refrigerator

A flow-through rotary damper assembly providing highly efficient, essentially laminar fluid flow therethrough is provided. The rotary damper assembly includes a cylindrical outer body and a cylindrical inner body that are rotatable in relation to one another. The outer body defines apertures in relation to one another to allow fluid flow without requiring fluid direction change. The inner body defines a flow passage having inlet and outlet apertures that may be aligned with the apertures of the outer body to allow fluid flow therethrough, or may be rotated out of alignment to block fluid flow. The outer body includes an aperture on one end to allow fluid flow to a third compartment. The inner body also includes an end aperture that may be aligned therewith. The damper provides selectable fluid flow between each of the compartments depending on the relative position of the cylindrical inner body member.

Method and apparatus for forming fluff pads for diapers and the like

Credit card carriers and methods of manufacture

Single-sheet, multi-panel carriers for receiving and retaining credit cards during credit card issue and mailing procedures. Cards may be inserted in the carriers manually or by machine. Plural carrier forms are preferably provided in a continuous fan-folded web, and individual carriers are separable therefrom at perforations between subsequent and/or adjacent carriers. The carriers have special slits or slots for retaining one to four cards singly, or double that in a piggy-back manner, in vertical or horizontal configurations. Carriers also have a plurality of panels which assist in retaining the cards by wedge trapping during manual or machine issue processing (inserting, collating, verification and stuffing) and mailing operations. Carriers also carry verification and/or identification information thereon relating to the account, e.g., name, number of cards, account(s) number(s), credit limit, address, debit usage criteria, and the like, in one or more forms which may be read visually, electro-optically, mechanically, optically, electromechanically, magnetically and/or electronically. Carriers are specially adapted for production by sheet-fed glued, or roll-to-fold, high-speed web printing procedures. Imprinting of verification and/or identification indicia may be done by any impact or non-impact procedures, e.g., by drum, line, or computer-controlled, non-impact, spray-type printers.

Addition and measurement of gases dissolved in molten metals

Method and apparatus for measuring gases dissolved in molten metal. Also disclosed are method and apparatus for dissolving gases in molten metal and a method of forming a gas permeable but molten metal impervious ceramic tube. A ceramic member is leached by an invention process so as to be selectively gas permeable. The member is inserted into molten metal to submerge the permeable portion. Then a vacuum is applied to the member and dissolved gases are measured by the change in pressure caused by gases entering from the molten metal. In another embodiment gas is applied to the submerged member to cause it to dissolve in the molten metal.

APPARATUS AND PROCESS FOR THE ACCUMULATION OF PRODUCTS IN BATTERIES