System and method for maintaining cache coherency across a serial interface bus using a snoop request and complete message

Techniques are disclosed for maintaining cache coherency across a serial interface bus such as a Peripheral Component Interconnect Express (PCIe) bus. The techniques include generating a snoop request (SNP) to determine whether first data stored in a local memory is coherent relative to second data stored in a data cache, the snoop request including destination information that identifies the data cache on the serial interface bus and causing the snoop request to be transmitted over the serial interface bus to a second processor. The techniques further include extracting a cache line address from the snoop request, determining whether the second data is coherent, generating a complete message (CPL) indicating that the first data is coherent with the second data, and causing the complete message to be transmitted over the bus to the first processor. The snoop request and complete messages may be vendor defined messages.

Pyrrolotriazine kinase inhibitors

The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

4-oxo-3,4-dihydroquinazoline compounds as inhibitors of human immunodeficiency virus replication

Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:

Mobility Device

A powered balancing mobility device that can provide the user the ability to safely navigate expected environments of daily living including the ability to maneuver in confined spaces and to climb curbs, stairs, and other obstacles, and to travel safely and comfortably in vehicles. The mobility device can provide elevated, balanced travel.

Medical treatment system and methods using a plurality of fluid lines

Improvements in fluid volume measurement systems are disclosed for a pneumatically actuated diaphragm pump in general, and a peritoneal dialysis cycler using a pump cassette in particular. Pump fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections of the apparatus being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a pump chamber of a diaphragm pump are also disclosed, in this case using a one-chamber ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the pump chamber. Improved heater control circuitry is also disclosed, to provide added or redundant safety measures, or to reduce current leakage from a heater element during pulse width modulation control of the heater. Improvements are also disclosed in the application of negative pressure during a drain phase in peritoneal dialysis therapy, and to control the amount of intraperitoneal fluid accumulation during a therapy. Improvements in efficiency are also disclosed in the movement of fluid into and out of a two-pump cassette and heater bag of a peritoneal dialysis cycler, and in the synchronization of the operation of two or more pumps in a peritoneal dialysis cycler or other fluid handling devices using a multi-pump arrangement.

Portable hair styling device with massaging bristles and formulation dispenser

A hair and scalp treatment device that comprises a dispenser connected to a cartridge, wherein the cartridge comprises a formulation; a plurality of tips on the device, wherein the tips have at least one opening to dispense the formulation; and a controller configured to control the dispensing of the formulation through one or more tips individually.

Medical Treatment System and Methods Using a Plurality of Fluid Lines

Improvements in fluid volume measurement systems are disclosed for a pneumatically actuated diaphragm pump in general, and a peritoneal dialysis cycler using a pump cassette in particular. Pump fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections of the apparatus being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a pump chamber of a diaphragm pump are also disclosed, in this case using a one-chamber ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the pump chamber. Improved heater control circuitry is also disclosed, to provide added or redundant safety measures, or to reduce current leakage from a heater element during pulse width modulation control of the heater. Improvements are also disclosed in the application of negative pressure during a drain phase in peritoneal dialysis therapy, and to control the amount of intraperitoneal fluid accumulation during a therapy. Improvements in efficiency are also disclosed in the movement of fluid into and out of a two-pump cassette and heater bag of a peritoneal dialysis cycler, and in the synchronization of the operation of two or more pumps in a peritoneal dialysis cycler or other fluid handling devices using a multi-pump arrangement.

Sequential multi-layer cognitive network optimization

System and methods for providing a cognitive network ( 300 ). The methods involve generating Initialization Parameters (“IPs”) for a first Multi-Objective Optimization (“MOO”) algorithm based on project requirements; determining a first Pareto Front (“PF”) for a first Protocol Stack Layer (“PSL”) of a protocol stack by solving the first MOO algorithm using IPS ( 450, 550 ); initialize or constrain a second MOO algorithm using the first PF ( 100 ); determining a second PF for a second PSL succeeding the first PSL using the second MOO algorithm; analyzing the first and second PFs to develop Best Overall Network Solutions (“BONSs”); ranking the BONSs according to a pre-defined criteria; identifying a top ranked solution for BONSs that complies with current regulatory and project policies; computing configuration parameters for protocols of PSLs that enable implementation of the top ranked solution within the cognitive network; and dynamically re-configuring network resources of PSLs using the configuration parameters.

Communication systems and methods for cognitive interference mitigation

Systems and methods for operating a receiver. The methods comprise: receiving, at the receiver, a combined waveform comprising a combination of a desired signal and an interference signal; and performing, by the receiver, demodulation operations to extract the desired signal from the combined waveform. The demodulation operations comprise: obtaining, by the receiver, machine learned models for recovering the desired signal from combined waveforms; comparing, by the receiver, at least one characteristic of the received combined waveform to at least one of the machine learned models; and determining a value for at least one symbol of the desired signal based on results of the comparing.

Cross-layer, cross-node cognitive network enhanced dynamic spectrum allocation

Systems ( 100 ) and methods ( 700 ) for dynamically managing Secondary User Node (“SUN”) access to a segment of a wireless spectrum licensed for use by Primary User Nodes (“PUNs”). The methods comprise: detecting physical data transfers by PUNs ( 110 - 122 ) at first licensed frequencies (f 1 , f 2 , f 3 , f 4 ) during slot sample times of a first epoch (t1-t15); generating a report comprising sensed spectral data indicating (a) during which of the slot sample times each physical data transfer was detected by a respective SUN ( 102 - 108 ) and (b) at which of the first licensed frequencies each physical data transfer occurred; receiving a report broadcasted from a remote SUN at a non-licensed frequency during a respective slot report times (t16-t19) of the first epoch; and analyzing the sensed spectral data of the reports to determine a time for using a first licensed frequency without interfering with or only minimally interfering with use thereof by PUNs.

Surgical staplers with independently actuatable closing and firing systems

A surgical instrument with separate actuatable closure and firing systems for closing a movable jaw and actuating a firing member. In one form, the surgical instrument comprises an elastic spine assembly that includes a proximal spine portion and a distal spine portion that is elastically coupled to the proximal spine portion for axial movement relative thereto between a neutral position and an elongated position such that during actuation of the firing system results in an increased application of closure motions to the movable jaw without actuating the closure system.

Methods of stereoselective synthesis of substituted nucleoside analogs

The present invention relates to the novel diastereoselective syntheses for generating phosphorothioate compounds. Examples include nucleoside phosphorothioate analogs that are useful in treating diseases and/or conditions such as viral infections.

Surgical stapling instrument with an articulatable end effector

In various embodiments, a surgical instrument can comprise an end effector including a staple cartridge and a datum portion positioned proximal to the staple cartridge. The surgical instrument can further comprise a shaft and an articulation joint configured to articulate the end effector relative to the shaft. In addition, the surgical instrument can further comprise a firing member configured to deploy a plurality of staples from the staple cartridge and a drive assembly including a drive member configured to move the firing member. The drive assembly may also include a stop configured to engage the datum portion to limit the movement of the drive member after the plurality of staples are fired.

Tap device with multi-tap feature for expanded character set

A method for processing user input entered via a data entry system includes the steps of receiving a signal representative of a contact of one or more fingers singly or in combination against an arbitrary surface; detecting a predetermined number of contacts within a time window; and mapping the predetermined number of contacts to a secondary character from a set of secondary characters.

Method of Calibrating a Blood Pressure Measurement Device

Systems, methods, and devices of the various embodiments enable calibration of continuous non-interfering blood pressure measurement devices. The measured quantity may be related to an arterial lumen or arterial cross sectional area. The arterial cross-sectional area may be related to transmural pressure, and thus the measured quantity may be related to transmural pressure by applying the first relationship to the second relationship. Sensor outputs may be obtained at a number of different heights, while the blood pressure measurement device is attached to the limb of a patient. The obtained sensor outputs may be used to determine a set of unknown parameters associated with the relationship of the transmural pressure to the sensor output. Upon determination of the parameters, the relationship of the transmural pressure to the sensor output may be used to obtain blood pressure measurements.

Capacitive liquid crystal biosensors

A capacitive liquid crystal (LC) biosensor for sensing a target biological agent includes a support board; a flow channel on the support board, the flow channel having an inlet port at a first end and an exit port at a second end; at least two electrodes, the at least two electrodes including a first electrode on a flow channel first surface and a second electrode on a flow channel second surface opposite the flow channel first surface; an electricity source connected to the first electrode and the second electrode; and an LC sensor array positioned within the flow channel. An LC sensor array includes a sensor support surface; wells positioned on the sensor support surface; an organic LC phase within each of the plurality of wells; and an aqueous phase having an analyte positioned above the organic LC phase within the wells.

Surgical staplers with independently actuatable closing and firing systems

A surgical instrument with separate actuatable closure and firing systems for closing a movable jaw and actuating a firing member. In one form, the surgical instrument comprises an elastic spine assembly that includes a proximal spine portion and a distal spine portion that is elastically coupled to the proximal spine portion for axial movement relative thereto between a neutral position and an elongated position such that during actuation of the firing system results in an increased application of closure motions to the movable jaw without actuating the closure system.

Surgical stapling instrument with an articulatable end effector

A surgical system comprising a housing assembly, a shaft extending from the housing assembly, a closure system, an end effector extending from the shaft, and a rotation system is disclosed. The housing assembly comprises a motor. The end effector is configurable in an unclamped configuration and a clamped configuration. The end effector is moved into the clamped configuration by the closure system. The end effector comprises a staple cartridge and a firing member. The staple cartridge comprises a plurality staples. The firing member is configured to move through the staple cartridge and deploy the plurality of staples. The rotation system is configured to rotate the end effector about a rotation axis when the end effector is in the unclamped configuration and prevent the end effector from rotating about the rotation axis when the end effector is in the clamped configuration.

Surgical end effectors and adaptable firing members therefor

Surgical end effectors are disclosed. The surgical end effectors can include a first jaw, a second jaw, and a firing member configured to translate relative to the first jaw and the second jaw during a firing stroke. The firing member can include at least one floating flange. The floating flange can be configured to shift or slide relative to a fixed portion of the firing member such as a fixed flange.

Firing member pin angle

A surgical instrument comprising a first jaw, a second jaw, and a firing member is disclosed. The firing member comprises one or more cams configured to position the first jaw relative to the second jaw. In various instances, one of the cams is oriented at a non-parallel angle relative to another cam in order to reduce strain within the cams. In certain instances, at least one of the cams comprises a leading projection and a trailing projection positioned behind the leading projection which are configured to engage the same jaw. The ends of the leading projection and the trailing projection are not attached to one another and can move relative to one another. In some instances, one or more of the cams has a plastically deformable or wearable feature configured to facilitate multiple uses of the surgical instrument.

Featureless coherent chaotic amplitude modulation

Systems ( 400, 500, 600 ) and methods ( 300 ) for generating a chaotic amplitude modulated signal absent of cyclostationary features by preserving a constant variance. The methods involve: generating a PAM signal including pulse amplitude modulation having a periodically changing amplitude; generating a first part of a constant power envelope signal (FPCPES) by dividing the PAM signal by a square root of a magnitude of the PAM signal; generating a second part of the constant power envelope signal (SPCPES) having a magnitude equal to a square root of one minus the magnitude of the PAM signal; and generating first and second spreading sequences (FSS and SSS). The methods also involve combining the FPCPES with the FSS to generate a first product signal (FPS) and combining the SPCPES with the SSS to generate a second product signal (SPS). A constant power envelope signal is generated using the FPS and SPS.

Featureless coherent chaotic amplitude modulation

Systems ( 400, 500, 600 ) and methods ( 300 ) for generating a chaotic amplitude modulated signal absent of cyclostationary features by preserving a constant variance. The methods involve: generating a PAM signal including pulse amplitude modulation having a periodically changing amplitude; generating a first part of a constant power envelope signal (FPCPES) by dividing the PAM signal by a square root of a magnitude of the PAM signal; generating a second part of the constant power envelope signal (SPCPES) having a magnitude equal to a square root of one minus the magnitude of the PAM signal; and generating first and second spreading sequences (FSS and SSS). The methods also involve combining the FPCPES with the FSS to generate a first product signal (FPS) and combining the SPCPES with the SSS to generate a second product signal (SPS). A constant power envelope signal is generated using the FPS and SPS.

化學鏈接劑與可裂解基質以及其之綴合物

FARMACO-LIGANDO CONJUGATES AND PHARMACO-SCINDIBLE SUBSTRATES, COMPOSITIONS CONTAINING THEM; USEFUL IN TUMORS AND CANCER TREATMENT

Conjugados de fármaco-ligando y sustratos fármaco-escindibles que son citotoxinas potentes. Reivindicacion 1: Un compuesto de la formula (1) en donde L1 es un enlazador auto-inmolativo; m es un entero 0, 1, 2, 3, 4, 5 o 6; F es un enlazador que comprende la estructura (2) donde AA1 es uno o más miembros independientemente seleccionados del grupo que consiste de amino ácidos naturales y alfa-amino ácidos no naturales; c es un entero de 1 a 20; L2 es un enlazador auto-inmolativo y comprende la estructura (3) donde cada R17, R18, y R19 es seleccionado independientemente de H, alquilo sustituido, alquilo no sustituido, heteroalquilo sustituido, heteroalquilo no sustituido, arilo sustituido y arilo no sustituido, y w es un entero de 0 a 4; o es 1, L4 es un miembro enlazador, p es 0 o 1; X4 es un miembro seleccionado del grupo que consiste de grupos funcionales reactivos protegidos, grupos funcionales reactivos no protegidos, marcadores detectables, y agentes orientadores; y D comprende la estructura (4) donde el sistema de anillo A es un miembro seleccionado de un grupo arilo sustituido o no sustituido, heteroarilo sustituido o no sustituido y grupos heterocicloalquilo sustituidos o no sustituidos, E y G son miembros independientemente seleccionados de H, alquilo sustituido o no sustituido, heteroalquilo sustituido o no sustituido, un heteroátomo, un enlace simple, o E y G se juntan para formar un sistema de anillo seleccionado de arilo sustituido o arilo no sustituido, heteroarilo sustituido o heteroarilo no sustituido, heterocicloalquilo sustituido o heterocicloalquilo no sustituido; X es un miembro seleccionado de O, S y NR23; R23 es un miembro seleccionado de H, alquilo sustituido o alquilo no sustituido, heteroalquilo sustituido o heteroalquilo no sustituido, y acilo; R3 es OR11; en donde R11 es un miembro seleccionado del grupo que consiste de H, alquilo sustituido, alquilo no sustituido, heteroalquilo sustituido, heteroalquilo no sustituido, monofosfatos, ...

'' COMPOUND ''

Enlazadores quimicos y sustratos escindibles y conjugados de los mismos.

La presente invención proporciona conjugados de fármaco-ligando y sustratos fármaco-escindibles que son citotoxinas potentes. La divulgación también está dirigida a composiciones que contienen conjugados fármaco-ligando y métodos de tratamiento que los emplean.

Kjemiske bindingsgrupper og spaltbare substrater og konjugater derav

Foreliggende oppfinnelse tilveiebringer legemiddel-ligandkonjugater og legemiddel-spaltbare substratkonjugater som er potente cytotoksiner. Beskrivelsen angår også sammensetninger som inneholder legemiddel-ligandkonjugatene og fremgangsmåter for behandling ved anvendelse av dem.

Chemical linkers and cleavable substrates and conjugates thereof

Disclosed are compounds of formula (I) wherein the substituents are disclosed within the specification. The disclosed compounds involve linkers and cleavable substrates that attach to a drug and a ligand and are cleaved in vivo. The linkers and cleavable substrates are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties.

Chemical linkers and cleavable substrates and conjugates thereof

Abstract The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Chemical linkers and cleavable substrates and conjugates thereof

Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues

The invention pertains to anti-CD30 antibodies that lack fucosyl and xylosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to Iyse CD30-expressing cell lines that are not lysed by the fucosylated and xylosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl and xylosyl residues, wherein the host cells are deficient for a fucosyltransferase and a xylosyltransferase. Methods of using the antibodies to inhibit the growth of CD30+ cells, such as tumor cells, are also provided.

Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues

Human monoclonal antibodies to btla and methods of use

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to BTLA with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for detecting BTLA, as well as methods for treating various diseases, including cancer and infectious diseases, using anti- BTLA antibodies.

Cd19 antibodies and their uses

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD 19 with high affinity. Nucleic acid molecules encoding such CD 19 antibodies, expression vectors, host cells and methods for expressing the CD 19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD 19 antibodies are also provided. Methods for detecting CD 19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.

Multimodal Adaptive User Interface for a Portable Electronic Device

A multimodal electronic device ( 100 ) includes a shutter enabled dynamic keypad for presenting one of a plurality of keypad configurations to a user. Each keypad configuration, which is presented by an optical shutter ( 204 ) that opens or closes windows or shutters that are geometrically configured as alphanumeric or device keys or symbols. Each keypad configuration comprises a plurality of mode based actuators, wherein the plurality of mode based actuators comprises at least a ten-digit keypad actuator set ( 2000 ) and a curved scroll device ( 1903 ). The optical shutter ( 204 ) is a low-resolution display that presents user actuation targets to a user in a low-resolution key area. As each mode of the device changes, the corresponding keypad configuration presented changes accordingly.

Optical film, assembly and display device

Polymerizable compositions comprising nanoparticles

Polymerizable compositions comprising nanopartilces particularly useful for brightness enhancing films.

POLYMERIZABLE COMPOSITIONS FOR OPTICAL ARTICLES

Polymerisierbare Zusammensetzungen für optische Artikel

Polymerizable composition comprising low molecular weight organic component

Polymerizable compositions comprising particularly useful for brightness enhancing films.

Polymerizable compositions comprising nanoparticles

Presently described are microstructured articles such as a brightness enhancing film or optical turning film. The microstructured articles comprise a brightness enhancing polymerized structure comprising the reaction product of a composition comprising an organic component having at least one oligomeric urethane (meth)acrylate and surface modified silica nanoparticles.

System for calculating a change in fluid volume in a pumping chamber

Surgical stapling instrument with an articulatable end effector

A surgical instrument can comprise a channel configured to support a staple cartridge and, in addition, an anvil pivotable between open and closed positions relative to the channel. The surgical instrument can further comprise a cutting member configured to incise tissue positioned captured between the staple cartridge and the anvil and, in addition, means for stopping the cutting member prior to a distal end datum, wherein the distal end datum can be defined by the distal-most staple cavity in the staple cartridge. In such embodiments, the incision within the tissue may not extend beyond the portion of the tissue that has been stapled.

Demixing sidedraws for distillation columns

The present invention provides one or more sidedraws, from the stripping section of a column, of a heavy key component in the presence of a desirable heavier than heavy key component. In addition, the present invention provides one or more sidedraws, from the rectification section of a column, of a light key component in the presence of a desirable lighter than light key component. In prior art columns, an inherent remixing of the components to be separated in downstream columns occurs near the top or bottom of refluxed or reboiled columns respectively. In the prior art, a re-separation of the remixed components from an upstream column must be done in downstream columns. The present invention eliminates or reduces, according to desired optimization, the remixing by removal of the heavy or light key components in the sidedraw stream.

Method and apparatus for delivering data from an information provider using the public switched network

The customer performs a search or otherwise defines selected data maintained by the information provider. Once the selected data is identified, the information provider maintains the requested data, typically by maintaining pointers identiying the data, but delays delivery of the requested data until the scheduled delivery time, such as a particular day and time requested by the customer or a non-peak period as determined by the information provider. When the information provider determines that delivery is appropriate, it makes a request for a suppressed ringing connection to a switching system. The switching system responds to the request for connection by creating a suppressed ringing connection where a silent alert tone or digital alert signal is transmitted to the customer premise equipment. The customer premise equipment includes a receiving system that receives one or more tones from the switching system over the suppressed ringing connection and becomes active. Upon being activated, the receiving system causes the customer's computer or portions of the computer such as a particular memory to power-up such that the computer can receive the data from the information provider.

Stored-value vessel

A stored-value vessel includes an end wall, a side wall, and an account identifier. The side wall extends around and away from the end wall to define a chamber therebetween. The chamber is configured to repeatedly receive one or more products for consumption by a bearer of the stored-value vessel. The account identifier is machine readable by a point-of-sale terminal and immovably included on at least one of the end wall and the side wall. The account identifier links the stored-value vessel to an account or record such that the stored-value vessel is configured to facilitate use of the stored-value vessel as one of payment toward a purchase of one or more of goods and services and an inventory tracking mechanism. Related vessels, cups and associated methods are also disclosed and provide additional advantages.

Surgical stapling instrument with an articulatable end effector

In various embodiments, a surgical instrument can comprise an end effector including a staple cartridge and a datum portion positioned proximal to the staple cartridge. The surgical instrument can further comprise a shaft and an articulation joint configured to articulate the end effector relative to the shaft. In addition, the surgical instrument can further comprise a firing member configured to deploy a plurality of staples from the staple cartridge and a drive assembly including a drive member configured to move the firing member. The drive assembly may also include a stop configured to engage the datum portion to limit the movement of the drive member after the plurality of staples are fired.

Surgical stapling instrument with an articulatable end effector

In various embodiments, a surgical instrument can comprise an end effector including a staple cartridge and a datum portion positioned proximal to the staple cartridge. The surgical instrument can further comprise a shaft and an articulation joint configured to articulate the end effector relative to the shaft. In addition, the surgical instrument can further comprise a firing member configured to deploy a plurality of staples from the staple cartridge and a drive assembly including a drive member configured to move the firing member. The drive assembly may also include a stop configured to engage the datum portion to limit the movement of the drive member after the plurality of staples are fired.

Distal radius plate

A distal radius plate having a head with a complex palm shaped profile which flares from the sides of the plate to a leading edge that includes a central oblique linking area that helps to mark the placement of the plate relative to the radius. Further, the plate includes an oblique depression that extends from the rounded pinky side of the head and gradually morphs into the elevated styloid prominence in one diagonal direction, and rises less gradually upward into the lunate prominence on the other side of the head. A proximal plate portion mimics the spiral of the radial bone as it spirals along the longitudinal axis, and includes a tighter radial bend. The head includes holes or bores for pegs which extend into the distal portion of the radius to lock fragments into position. In the first embodiment, the angles of the pegs are fixed. In a second embodiment, one or more of the peg holes are provided with a variable axis locking mechanism assembly and the remaining holes are fixed.

Orthopedic plate

An orthopedic plate has a portion with a curved bottom surface that is designed to extend longitudinally along the bone and change the inferior curve as it advances proximally along the bone from a shallower to a sharper radius and further spirals downward as the plate advances. The plate includes a set of tabs, offset from the longitudinal axis of the plate to provide for better pullout values. The ears may be located at the terminal portion of the plate or somewhat more intermediate to the terminus of the plate, depending on the intended application. A point in the center of the central screw hole can be used to define the origin of the plate, and the angles of the screw and/or pegs holes can be referenced with Z, Y, and Z coordinates relative to this central hole.

Medical treatment system and methods using a plurality of fluid lines

Improvements in fluid volume measurement systems are disclosed for a pneumatically actuated diaphragm pump in general, and a peritoneal dialysis cycler using a pump cassette in particular. Pump fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections of the apparatus being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a pump chamber of a diaphragm pump are also disclosed, in this case using a one-chamber ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the pump chamber. Improved heater control circuitry is also disclosed, to provide added or redundant safety measures, or to reduce current leakage from a heater element during pulse width modulation control of the heater. Improvements are also disclosed in the application of negative pressure during a drain phase in peritoneal dialysis therapy, and to control the amount of intraperitoneal fluid accumulation during a therapy. Improvements in efficiency are also disclosed in the movement of fluid into and out of a two-pump cassette and heater bag of a peritoneal dialysis cycler, and in the synchronization of the operation of two or more pumps in a peritoneal dialysis cycler or other fluid handling devices using a multi-pump arrangement.

X-ray detection system using active pixel sensors

An x-ray detector includes a scintillator that converts an invisible-radiant-energy image into a visible-light image and a sensor array that converts the visible-light image into an electrical signal. The sensor array comprises a plurality of CMOS active pixel sensors.

Method for reading out data from an x-ray detector

An x-ray detector includes a scintillator that converts an invisible-radiant-energy image into a visible-light image and a sensor array that converts the visible-light image into an electrical signal. The sensor array comprises a plurality of CMOS active pixel sensors.

Macrocycles and macrocycle stabilized peptides

The invention provides methods of preparing macrocycles including macrocycle stabilized peptides (MSPs). Macrocycles and MSPs are prepared according to nucleophilic capture of an iminoquinomethide type intermediate generated from a suitably substituted 2-amino-thiazol-5-yl carbinol. The preferred nucleophile may be selected from an electron rich aromatic moiety in the case of macrocycles and, in the case of MSPs, at least one amino acid comprises an electron rich aromatic moiety. In addition, the concept can be extended to other related 5-membered heterocyclic systems in place of the thiazole, such as imidazole or oxazole. The conditions for the generation of the corresponding iminoquinomethide type intermediates may be similar or different than the conditions used for the 2-amino-thiazol-5-yl carbinol.

Combinations comprising biphenyl derivatives for use in the treatment of HCV

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Hepatitis C virus inhibitors

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Hepatitis c virus inhibitors

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Polycyclic heterocycle derivatives and methods of use thereof for the treatment of viral diseases

Feed-through capacitors

Method for correcting optical path length in image photographing device

(57)【要約】 【課題】 光ファイバセンサシステムの製造コストの低 減が困難であった。 【解決手段】 光信号は、干渉計の第１及び第２の光枝 にそれぞれ案内される第１及び第２のビームに分割され る。固定ミラーは、第１の光枝の端部で受けた第１のビ ームを反射する。光ピックオフは、第２の光枝の端部か ら受けた第２のビームを反射するように配置された可動 ミラーを含む。可動ミラーは、測定されるべきパラメー タの値の変化に応じて移動可能になっている。光カップ ラは、第１及び第２のビームが反射されてそれぞれの光 枝内へ戻った後それらを合成し、光検出器で検出される 干渉信号を発生させる。検出器は、干渉信号の値を表わ す値を有する電子信号を発生する。電子信号は分析さ れ、その値と、測定されるべき環境パラメータの値の変 化の相関が取られる。

Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues

The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.

Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase

Methods of inhibiting orthopoxvirus replication with nucleoside compounds

Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase

The present invention provides nucleoside derivatives (principally uracil, cytosine and uridine derivatives) which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.

Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase

Methods of inhibiting orthopoxvirus replication with nucleoside compounds

Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase

compound, pharmaceutical composition and compound use

Minimization of systemic inflammation

The present invention relates to a water-insoluble controlled-release pattern recognition receptor agonist ("PRRA") for use in the treatment of a cell-proliferation disorder, wherein the water-insoluble controlled-release PRRA is administered by intra-tissue administration, and wherein the protein levels of at least one cytokine selected from the group consisting of IL-6, CCL2 and IL-10 in plasma has a more than 10-fold lower maximum protein level within 24 hours compared to an equivalent molar dose of the corresponding free PRRA upon intra/tissue administration; and to related aspects.

Anti-ctla4 compounds with localized pk properties

The present invention relates to a water-insoluble controlled-release anti-CTLA4 compound for use in the treatment of a cell-proliferation disorder, wherein said water-insoluble controlled-release anti-CTLA4 compound releases one or more anti-CTLA4 drugs, and wherein intra-tissue administration of a therapeutic dose results in a maximum systemic concentration of anti-CTLA4 drug within 48 hours after said intra-tissue administration that is at least 2-fold lower compared to the maximum systemic concentration of the corresponding anti-CTLA4 drug within 48 hours after systemic administration of a dose of said anti-CTLA4 drug that provides essentially the same anti-tumor activity; and related aspects.

Anti-ctla4 compounds with localized pd properties

The present invention relates to a water-insoluble controlled-release anti-CTLA4 compound for use in the treatment of a cell-proliferation disorder, wherein the compound is administered by intra-tissue administration and wherein such intra-tissue administration induces local anti-CTLA4-induced T cell activation; and related aspects.

Method of treating cancer using kinase inhibitors

Described herein are methods for treating cancer and other disease conditions in individuals who have either developed a resistance to conventional tyrosine kinase inhibitor (TKI) therapy or who are non-responsive ab initio to conventional TKI therapy. In various embodiments, the methods include administering to a patient a resistance-surmounting quantity of a TKI on a weekly or semi-weekly basis. Alternate embodiments of the present invention include a diagnostic method for assessing an individual's probability of being resistant to TKI therapy, based upon an expression level of epithelial membrane protein-1 (EMP-1); one of the genes believed to be responsible for TKI resistance. The methods of the present invention may be particularly useful in the treatment of lung, breast, prostate, ovarian, brain and colon cancers. The methods of the present invention may be effective in blocking the HER-2 kinase domain either in addition to or in lieu of blocking the EGFR kinase domain.

Surgical clip

A clip is provided that can be used for ligating tissue, such as vessels, other tubular ducts, and the like. The clip has opposed first and second leg members having proximal and distal ends. The proximal end of each leg member is connected by an apex having a notch formed therein. Moreover, each leg member has an inner tissue-contacting surface and an outer compression-receiving surface, both of which include features to provide a more secure ligation of the vessel or duct. A method of ligating vessels is also provided.

Surgical stapling instrument with an articulatable end effector

In various embodiments, a surgical instrument can comprise an end effector including a channel configured to support a staple cartridge and, in addition, an anvil pivotable between open and closed positions relative to the staple cartridge channel. The surgical instrument can further comprise a closure tube configured to at least partially surround the anvil and the staple cartridge channel to hold the anvil in a closed position. The closure tube can extend around the anvil a greater distance than the staple cartridge channel. The surgical instrument can further comprise a shaft and, in addition, an articulation joint pivotably connecting the end effector to the shaft. The articulation joint can further comprise a floating guide member which can guidably support a knife bar extending into the end effector and, at the same time, move independently of the end effector and the shaft to provide such support.

User interface for scrolling

A user interface can include a directional navigation interface and a scrolling strip at least partially circumscribing said navigation device. The scrolling strip can include a proportional scrolling zone and a multi-mode scrolling zone.

Medical imaging device and methods of use

Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed.

Medical imaging device and methods of use

Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed.

Medical imaging device and methods of use

Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed.

Partitioned distillation column

An integrated distillation column having a partitioned stripping or absorption section is presented. The integrated stripping/distillation column comprises a single shell housing a refluxed absorption section and a reboiled stripping section. The stripping section is partitioned by a vertical wall into first and second separate portions having upper end in fluid communication the absorption section. The stripping portions include fluid isolated lower ends having separate reboilers. In the integrated absorption/distillation column, the absorption section is partitioned and separate reflux loops are provided for each portion of the absorption section. In such a manner, a two column distillation process can be combined into one for achieving space and equipment savings.

Skin contouring using photo-responsive materials

Methods, systems, and devices for integrated photo-responsive contouring treatment are described. Methods include identifying a region of skin corresponding to a contouring treatment of the skin. The region of skin may be provided with a photo-responsive material overlying a portion of the region of the skin. Methods may include identifying one or more treatment regions overlapping the photo-responsive material. The treatment regions may be identified at least in part to apply the contouring treatment. Methods may include determining an irradiation profile for each of the one or more treatment regions to contour each respective treatment region as part of applying the contouring treatment. Methods may also include irradiating the photo-responsive material at the one or more treatment regions in accordance with the respective irradiation profiles. Irradiating the photo-responsive material may induce a localized change in shape of the photo-responsive material in the respective treatment regions.

Non-planar sputter targets having crystallographic orientations promoting uniform deposition

A non-planar sputter target having differing crystallographic orientations in portions of the sputter target surface (25) that promote more desirable deposition and density patterns of material sputtered from the target surface onto a substrate is disclosed. A closed dome (22) end of the sputter target (20) is comprised of a first crystallographic orientation and sidewalls (24) of the sputter target are comprised of a crystallographic orientation different from that of the dome. The sputter target is formed, preferably by hydroforming or other metal working techniques, in the absence of annealing. The hydroforming manipulations result in the different crystallographic orientations while minimizing, or ideally omitting, the application of heat. Quick and cost effective non-planar sputter targets that are easily repeatably producable are achievable as a result. There are vectors (α, β1, β2) in the target.

compound, pharmaceutical composition, and use of a compound

COMPOSTO, COMPOSIçãO FARMACêUTICA, E, USO DE UM COMPOSTO A presente invenção refere-se a compostos macrocíclicos da fórmula (1), que são úteis como inibidores de protease NS3 do vírus de hepatite C (HCV), a sua síntese, e o seu uso para o tratamento ou a prevenção de infecções por HCV. COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE OF A COMPOUND The present invention relates to macrocyclic compounds of formula (1), which are useful as hepatitis C virus (HCV) NS3 protease inhibitors, their synthesis, and their use for the treatment or prevention of HCV infections.

Antibodies to il-6 and their uses

ANTIBODIES TO IL-6 AND THEIR USESAntibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.Figure 2

Mobility device

A powered balancing mobility device that can provide the user the ability to safely navigate expected environments of daily living including the ability to maneuver in confined spaces and to climb curbs, stairs, and other obstacles, and to travel safely and comfortably in vehicles. The mobility device can provide elevated, balanced travel.

Proline bis-amide orexin receptor antagonists

The present invention is directed to proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

POLISHING SKATE WITH DOUBLE POROSITY STRUCTURE

Le patin de polissage est utile pour polir au moins un substrat parmi les substrats magnétiques, optiques et semi-conducteurs. Une couche de polissage poreuse comprend une structure à porosité double dans une matrice de polyuréthane. La structure à porosité double a un ensemble principal de pores ayant des parois de pore avec une épaisseur de 15 à 55 µm et un module d'accumulation de 10 à 60 MPa mesuré à 25 °C. De plus, les parois de pore contiennent un ensemble secondaire de pores ayant une taille de pore moyenne de 5 à 30 µm. La couche de polissage poreuse est fixée sur un substrat à feuille ou film polymère ou bien sous la forme d'une structure tissée ou non-tissée afin de former le patin de polissage. The polishing pad is useful for polishing at least one of the magnetic, optical and semiconductor substrates. A porous polishing layer comprises a double porosity structure in a polyurethane matrix. The double porosity structure has a main pore assembly having pore walls with a thickness of 15 to 55 μm and an accumulation module of 10 to 60 MPa measured at 25 ° C. In addition, the pore walls contain a secondary set of pores having an average pore size of 5 to 30 μm. The porous polishing layer is attached to a polymeric sheet or film substrate or in the form of a woven or nonwoven structure to form the polishing pad.

MECHANICAL CHEMICAL POLISHING PAD WITH WINDOW, FLEXIBLE AND CONDITIONABLE

Il est mis à disposition un tampon de polissage chimique mécanique contenant : une couche de polissage ; un bloc-fenêtre de détection de point limite encastré ; une couche rigide ; et un adhésif thermofusible collant la couche de polissage à la couche rigide ; dans lequel la couche de polissage comprend le produit de la réaction d'ingrédients comprenant : un isocyanate polyfonctionnel ; et un système durcisseur ; dans lequel le système durcisseur contient un durcisseur polyol amorcé par une amine et un durcisseur polyol de masse moléculaire élevée ; dans lequel la couche de polissage présente une densité supérieure à 0,6 g/cm3 ; une dureté Shore D de 5 à 40 ; un allongement à la rupture de 100 à 450 % ; et une vitesse de coupe de 25 à 150 µm/h ; et dans lequel la couche de polissage a une surface de polissage adaptée au polissage du substrat. Il est également mis à disposition des procédés pour produire et utiliser le tampon de polissage chimique mécanique. It is provided with a mechanical chemical polishing pad containing: a polishing layer; a built-in limit point detection window; a rigid layer; and a hot melt adhesive adhering the polishing layer to the rigid layer; wherein the polishing layer comprises the product of the reaction of ingredients comprising: a polyfunctional isocyanate; and a hardener system; wherein the hardener system contains an amine-initiated polyol hardener and a high molecular weight polyol hardener; wherein the polishing layer has a density greater than 0.6 g / cm3; a Shore D hardness of 5 to 40; an elongation at break of 100 to 450%; and a cutting speed of 25 to 150 μm / h; and wherein the polishing layer has a polishing surface adapted to polish the substrate. Methods are also provided for producing and using the mechanical chemical polishing pad.

MECHANICAL CHEMICAL POLISHING PAD, METHOD FOR PRODUCING THE SAME, AND POLISHING METHOD USING THE SAME

L'invention concerne un tampon de polissage mécanochimique comprenant une couche de polissage en polyuréthane acrylate, où la couche de polissage présente un module de traction de 65 à 500 MPa, un allongement à la rupture de 50 à 250%, un module de conservation, G', de 25 à 200 MPa, une dureté Shore D de 25 à 75 et une vitesse de coupe humide de 1 à 10 pm/min ; l'invention concerne en outre un procédé de production de ce tampon de polissage et un procédé de polissage l'utilisant. The invention relates to a mechanochemical polishing pad comprising a polyurethane acrylate polishing layer, wherein the polishing layer has a tensile modulus of 65 to 500 MPa, an elongation at break of 50 to 250%, a conservation modulus, G ', from 25 to 200 MPa, a Shore D hardness of 25 to 75 and a wet cutting speed of 1 to 10 μm / min; the invention further relates to a method of producing this polishing pad and a polishing method using it.

MECANO-CHEMICAL POLISHING FELT WITH FLEXIBLE WINDOW AND TREATMENT-FRIENDLY

Il est fourni un feutre de polissage mécano-chimique (10) présentant une couche de polissage (20) ; et une fenêtre (30) incorporée dans la couche de polissage ; dans lequel la couche de polissage comprend un produit de réaction d'ingrédients, comprenant : un prépolymère de couche de polissage et un système de durcisseur de couche de polissage ; dans lequel le système de durcisseur de couche de polissage comprend un durcisseur de couche de polissage de polyol initié par une amine, un durcisseur de couche de polissage de polyol de masse moléculaire élevée et un durcisseur de couche de polissage difonctionnel ; et, dans lequel la fenêtre comprend un produit de réaction d'ingrédients, comprenant : un prépolymère de fenêtre et un système de durcisseur de fenêtre ; dans lequel le système de durcisseur de fenêtre comprend un durcisseur de fenêtre difonctionnel ; un durcisseur de fenêtre de polyol initié par une amine et un durcisseur de fenêtre de polyol de masse moléculaire élevée ; et, dans lequel la couche de polissage présente une densité ≥ 0,6 g/cm3 ; une dureté Shore D de 5 à 40 ; un allongement à la rupture de 100 à 450 % ; et, une vitesse de découpe de 25 à 150 µm/h. There is provided a chemical mechanical polishing felt (10) having a polishing layer (20); and a window (30) incorporated in the polishing layer; wherein the polishing layer comprises an ingredient reaction product, comprising: a polishing layer prepolymer and a polishing layer hardener system; wherein the polishing layer hardener system comprises an amine initiated polyol polishing layer hardener, a high molecular weight polyol polishing layer hardener and a difunctional polishing layer hardener; and wherein the window comprises an ingredient reaction product comprising: a window prepolymer and a window hardener system; wherein the window hardener system comprises a difunctional window hardener; an amine initiated polyol window hardener and a high molecular weight polyol window hardener; and, ...

Digital generation of a chaotic numerical sequence

A method is provided for generating a chaotic sequence. The method includ es selecting a plurality of polynomial equations. The method also includes u sing residue number system (RNS) arithmetic operations to respectively deter mine solutions for the polynomial equations. The solutions are iteratively c omputed and expressed as RNS residue values. The method further includes det ermining a series of digits in a weighted number system (e.g., a binary numb er system) based on the RNS residue values. According to an aspect of the in vention, the method includes using a Chinese Remainder Theorem process to de termine a series of digits in the weighted number system based on the RNS re sidue values. According to another aspect of the invention, the determining step comprises identifying a number in the weighted number system that is de fined by the RNS residue values.

ALKALINE-EARTH METAL OXIDE COMPOSITE AND HOLLOW POLYMER

PERSONAL POLLUTION SENSING DEVICE WITH EXTENDED BATTERY LIFE

Dispositif de captage de pollution personnel doté d’une durée de vie de batterie prolongé e L’invention concerne un système d’ordinateur et le procédé implémenté par ordinateur de prolongation de la durée de vie de batterie d’un dispositif de captage vestimentaire personnel, le procédé comprend la détermination d’une localisation en cours du dispositif de captage ; la détermination de localisations de dispositifs de surveillance d’environnement accessibles au public ; la détermination du fait que la localisation en cours est ou non dans une limite de proximité d’un dispositif de surveillance d’environnement accessible au public ; et la réception d’informations depuis le dispositif de surveillance d’environnement accessible au public lorsque la localisation en cours est dans la limite de proximité du dispositif de surveillance d’environnement accessible au public pour économiser la durée de vie de batterie du dispositif de captage. Figure pour l'abrégé : 1

determining the position of a personal care device relative to the BODY surface

D étermination de la position d’un dispositif de soin personnel par rapport à la surface corporelle L’invention concerne un système d’ordinateur qui obtient un modèle numérique tridimensionnel d’une surface corporelle, telle qu’un visage humain. Des portions de la surface correspondent à des points de référence dans le modèle. Le système obtient des données d’image d’un dispositif de soin personnel en utilisation ainsi que des données d’image de la surface sur lesquelles le modèle est basé. Le système calcule un emplacement relatif du dispositif par rapport aux points de référence sur la base des données d’image de la surface. Le système détermine une position réelle du dispositif par rapport à la surface sur la base des données d’image du dispositif en utilisation, des dimensions physiques connues du dispositif et de son emplacement relatif, même lorsque le dispositif est partiellement masqué. Le système peut, sur la base de la position réelle du dispositif, amener le dispositif à réaliser des actions telles que l’application d’un produit cosmétique ou l’administration d’une thérapie cutanée Figure pour l’abrégé : 1 Determining the Position of a Personal Care Device Relative to the Body Surface A computer system obtains a three-dimensional digital model of a body surface, such as a human face. Portions of the surface correspond to reference points in the model. The system obtains image data from a personal care device in use as well as image data from the surface on which the model is based. The system calculates a relative location of the device to the reference points based on the surface image data. The system determines an actual position of the device relative to the surface based on image data of the device in use, known physical dimensions of the device, and its relative location, even when the device is partially obscured. The system can, based on the device's actual position, cause the device to perform actions such as applying a cosmetic product or ...

Component imagery system

A large database (10, 11, 114) of digitized background images (12) is provided with one or more attributes (14, 16, 18, 15, 17, 19, 116, 118) associated with each image. Preferably most if not all of the attributes are expressed numerically. The attributes can pertain to lighting conditions at the time the associated photograph was taken, and camera orientation. Such conditions can include the horizontal angle of the primary lighting (H), the vertical angle of the primary lighting (V), a measure of the apparent ground perspective (P), color temperature (CT), a measure of light diffusion (D), a measure of the degree of ambient light (A), and horizontal depth of field focal range boundaries (NF, FF). The database is searchable by one or more of these attributes and/or by subject. A user can select a desired background image and learn the attributes associated with that image. A subject image having matching attributes then can be composited with the background image for a realistic composite montage.

Method for silently alerting inbound-only telemetry interface units

The system of the invention consists of a central office service unit (COSU) connected to a plurality of switching systems via dedicated telemetry trunks or a common channel signaling network such as the CCS7 network. The switching systems are connected to a plurality of inbound-only TIUs located on the customer premise that are in turn connected to customer devices such as utility meters, appliances, security systems or the like. The TIUs are inbound-only that can originate calls but cannot answer calls initiated by the controlling entity. A controlling entity, such as a utility, is connected to one of the switching systems over a customer line such that the controlling entity can be connected to any TIU hosted by the switching systems. The controlling entity requests that an alerting tone be sent by the COSU to a desired TIU. The COSU, as is known in the art delivers an alert tone through a suppressed ringing connection to the TIU that does not audibly ring the customer's telephone. The TIU does not "answer" this tone by going off hook such that no connection is established and the telemetry call is taken down. While the TIU does not answer the alert tone, the tone alerts the TIU to perform one or more functions such as retrieve data from a utility meter, check the status of an appliance or the like. As an alternative to the alert tone, a digital signal can be transmitted to alert the TIU. After performing the desired function, the TIU is programmed to call the controlling entity and a connection is established between the TIU and the controlling entity. The TIU can then transmit the results of thefunction to the controlling entity and the controlling entity can download further instructions, programs or the like to the TIU.

FORMATION OF A POLISHING BUFFER BASED ON ALKALINE-EARTH METAL OXIDE

POLISHING BUFFER BASED ON POLYMER AND ALKALINE-EARTH METAL OXIDE

Sine/cosine generator

A method (300) for generating a sine and cosine of an input angle (.SLZERO.102). The method involves decomposing .SLZERO.102 to an octant or quadrant, a coarse angle (A), and a fine angle (B), determining cos(A), and determining sin(A). The method also involves decomposing cos(A) and sin(A) to a most significant word (MSW) and a least significant word (LSW). The method further involves computing an approximation of 1-cos(B), an approximation of sin(B), and a plurality of products (P1,..., P4) using the MSWs and approximations. The method involves computing approximations of cos(.SLZERO.'102) and sin(.SLZERO.'102) using the values for cos(A), sin(A), and P1,..., P4. The method involves scaling the approximations of cos(.SLZERO.'102) and sin(.SLZERO.'102) to a desired resolution.

Dynamic multiple cluster system reconfiguration

According to the present invention, methods and apparatus are provided to allow dynamic multiple cluster system configuration changes. In one example, processors in the multiple cluster system share a virtual address space. Mechanisms for dynamically introducing and removing processors, I/O resources, and clusters are provided. The mechanisms can be implemented during reset or while a system is operating. Links can be dynamically enabled or disabled.

MECANO-CHEMICAL POLISHING SKIN FLEXIBLE AND PUTABLE