Recombinant yeast cells producing polylactic acid and uses thereof

The present invention relates to a recombinant yeast cell comprising a gene encoding a protein exhibiting lactyl-CoA synthase activity and a gene encoding a protein exhibiting lactyl-CoA polymerase activity, said recombinant cell having the ability of producing polylactic acid (PLA), and the uses thereof.

Controlling display brightness when rendering composed scene-referred and output-referred content

Devices and methods for controlling display brightness may include receiving a brightness input for controlling a luminance level of at least one display in communication with the computer device. The devices and methods may include receiving high dynamic range (HDR) content and standard dynamic range (SDR) content for presentation on at least one display. The devices and methods may include generating adjusted SDR content by using the brightness input to modify luminance of the SDR content. The devices and methods may include blending the adjusted SDR content and the HDR content together to create a composed framebuffer content with the adjusted SDR content and the HDR content and transmitting the composed framebuffer content for presentation on at least one display.

Binding moieties for biofilm remediation

Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

Hybrid temperature regulation circuit

A temperature regulation apparatus for a hybrid vehicle having a forced induction combustion engine and an electric drive motor, the apparatus comprising: a temperature regulating circuit carrying a fluid coolant; a heat exchanger for cooling the coolant; and a first coolant pump for circulating the coolant around the temperature regulating circuit; the temperature regulating circuit having: a first branch serving a charge air cooler of a forced induction combustion engine; and a second branch serving one or more electric drive components and including a second coolant pump for regulating the flow of the coolant through the one or more electric drive components; wherein the first and second branches of the temperature regulating circuit are arranged in parallel and the first coolant pump is arranged between the heat exchanger and the first and second branches of the temperature regulating circuit so as to be operable to circulate coolant from each of the first and second branches of the temperature regulating circuit through the heat exchanger.

DIALOGUE MANAGEMENT

A dialogue system comprising: 1. A module for updating a dialogue state for use in a dialogue system , the dialogue system for conducting a dialogue with a user , the module comprising:a user inputa processor; anda memorywherein the processor is adapted to update a dialogue state in response to a natural language input from a user, the dialogue state being stored in the memory,the dialogue state comprising a data structure that the stores the information exchanged between the user and the dialogue system, andthe processor being configured to update said dialogue state by comparing said natural language input from the user with a plurality of possible actions, said actions indicating possible requests of the user, and update the state using information from an action that matches with the natural language input.2. A module according to claim 1 , wherein the dialogue state comprises a data structure that comprises items that have been mentioned during the dialogue.3. A module according to claim 2 , wherein said plurality of possible actions includes actions regarding a plurality of items that have been mentioned during the dialogue.4. A module according to claim 1 , wherein the dialogue system is configured for information retrieval and said dialogue state comprises a user goal and history claim 1 , said user goal indicating information that the user requires claim 1 , said history defining items that have been previously retrieved in response to a user goal.5. A module according to claim 1 , wherein the processor is configured to compare the natural language input from the user with a plurality of possible actions claim 1 , by using a binary classifier to indicate actions that are a match and those which are not.6. A module according to claim 5 , wherein the binary classifier is configured to output a score and said score is compare with a threshold to determine if an action is a match.7. A module according to claim 6 , wherein the processor is configured to compare ...

Safety test method for determination of critical cell states by internal short provocation

A system ( 10 ) for testing a battery cell ( 1 ) by creating at least one of the effects of internal short circuit within the cell ( 1 ) with at least one cathode, at least one anode, at least one sensor ( 3 ) and at least one conductive heating element ( 2 ), comprising at least one resistive heat element ( 5 ), wherein at least the resistive heat element ( 5 ) is assembled within the cell ( 1 ) for simulating an internal short circuit.

Virulence attenuated bacteria based protein delivery

The present invention relates to recombinant virulence attenuated Gram-negative bacterial strains and its use in a method of treating cancer in a subject.

Combination therapies of chimeric antigen receptors and pd-1 inhibitors

Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.

Modular home energy system having a bus system and an ac vehicle charging device

A home energy system for storing and providing energy.

Computer resource allocation and scheduling system

Systems and methods for use in scheduling processes for execution on one or more data processors. A centralized governor module manages scheduling processes requesting access to one or more data processors. Each process is associated with a project and each project is allocated a computing budget. Once a process has been scheduled, a cost for that scheduling is subtracted from the associated projects computing budget. Each process is also associated with a specific process agent that, when requested by the governor module, provides the necessary data and parameters for the process. The governor module can thus implement multiple scheduling algorithms based on changing conditions and on optimizing changing loss functions. A log module logs all data relating to the scheduling as well as the costs, execution time, and utilization of the various data processors. The data in the logs can thus be used for analyzing the effectiveness of various scheduling algorithms.

Modular light fixture

A light fixture unit, an assembly thereof and a method for assembly thereof, the comprising a housing comprising opposed side walls, a projector assembly, and a junction box positioned within said housing above said projector assembly, the side walls of the housing comprising openings and an air channel being provided on each side of the junction box for evacuation of hot air generated within the housing. The side walls comprise at least one connexion element providing at least one angled surface within the housing. The side walls further comprise knocks generally at the level of the junction box within the housing.

Inhibitors of sarm1

The present disclosure provides compounds and methods useful for inhibiting SARMI and/or treating and/or preventing axonal degeneration. Provided SARMI inhibitors reduce or inhibit binding of NAD+ by SARMI and SARMI inhibitors bind to SARMI within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARMI).

ELECTRIC VEHICLE BRAKING SYSTEM, METHOD, CONTROLLER AND COMPUTER PROGRAM PRODUCT

The present invention relates to a controller () for a braking system for a vehicle (). The braking system has an independent generator () on respective front and rear axles (). The controller () comprises an input () arranged to monitor a vehicle condition and an operating condition of the generators (). The controller () also comprises a processing means () arranged to determine a brake force distribution range between the front and rear axles () based on the vehicle condition, and in response to a braking demand and the operating condition of the generators (), calculate a brake force distribution within the brake force distribution range. In addition, the controller () comprises an output () arranged to control the generators in accordance with the calculated brake force distribution. 1. A controller for a braking system for a vehicle , the braking system having an independent generator on respective front and rear axles , the controller comprising:an input arranged to monitor a vehicle condition and an operating condition of each generator;a processor arranged to determine a brake force distribution range between the front and rear axles based on the vehicle condition, and in response to a braking demand and the operating condition of each generator, calculate a brake force distribution within the brake force distribution range; andan output arranged to control each generator in accordance with the brake force distribution;wherein the vehicle condition is a parameter relating to vehicle stability, and wherein the brake force distribution range reduces as the parameter relating to vehicle stability falls; andwherein the brake force distribution range is arranged to taper and converge at an installed hydraulic brake force distribution.23-. (canceled)4. The controller of claim 1 , wherein the installed hydraulic brake force distribution is distributed with about 70% of a total braking force distributed to the front axle and about 30% of the total braking force ...

Wide bandgap semiconductor switching device with wide area schottky junction, and manufacturing process thereof

A switching device including: a body of semiconductor material, which has a first conductivity type and is delimited by a front surface; a contact layer of a first conductive material, which extends in contact with the front surface; and a plurality of buried regions, which have a second conductivity type and are arranged within the semiconductor body, at a distance from the contact layer.

Device for extracting a nucleic acid from a sample liquid

A device for extracting a nucleic acid from a sample liquid includes a heating element configured to be connected to an extraction nucleic acid. The extraction nucleic acid is at least partly complementary to the nucleic acid to be extracted from the sample liquid. The heating element is heatable to a temperature that is equal to or higher than a denaturing temperature of the nucleic acid bound to the extraction nucleic acid.

METHOD AND SYSTEM FOR PROCESSING NETWORK TRAFFIC USING EXPANDED LABELS

A method for managing traffic in a network. The method includes receiving an overlay frame comprising a header portion and obtaining, from the header portion, a first label and a second label. The method further includes generating an expanded label comprising the first label and the second label, making a first determination that an overlay network table comprises an entry for the expanded label, and based on the first determination, processing the overlay frame using the entry. 1. A method for managing traffic in a network , comprising:receiving an overlay frame comprising a header portion;obtaining, from the header portion, a first label and a second label;generating an expanded label comprising the first label and the second label;making a first determination that an overlay network table comprises an entry for the expanded label; andbased on the first determination, processing the overlay frame using the entry.2. The method of claim 1 , further comprising:making a second determination that the overlay network table does not include any entries for the first label,wherein the processing of the overlay frame using the entry is further based on the second determination.3. The method of claim 1 , further comprising:making a second determination that the overlay network table includes a second entry for the first label; andbased on the first and second determinations, making a third determination to process the overlay frame using the entry based on a permutation priority,wherein the processing of the overlay frame using the entry is further based on the second determination and the third determination.4. The method of claim 1 , further comprising:receiving a second overlay frame comprising a second header portion;obtaining, from the second header portion, a third label and a fourth label;generating a second expanded label comprising the third label and the fourth label;making a second determination that the overlay network table comprises a second entry for the ...

HIGH-FREQUENCY LINE FILTER

In a high-frequency line filter for a converter, the converter has three phase connections for receiving a three-phase alternating signal from a three-phase voltage network and is adapted to convert the received three-phase alternating signal into an output signal for a load. The high-frequency line filter includes: a first filter path for establishing a conductive connection between a first phase connection of the three phase connections and a ground connection; a second filter path for establishing a conductive connection between a second phase connection of the three phase connections and the ground connection; and a third filter path for establishing a conductive connection between a third phase connection of the three phase connections and the ground connection. The high-frequency line filter includes a series connection of a pulse-proof capacitor and a parallel connection of at least two Y capacitors, the series connection being provided in each filter path. 1. A high-frequency line filter for a converter having three phase connections adapted to receive a three-phase alternating signal from a three-phase voltage network and adapted to convert the received three-phase alternating signal into an output signal for a load , comprising:a first filter path adapted to establish a conductive connection between a first phase connection of the three phase connections and a ground connection;a second filter path adapted to establish a conductive connection between a second phase connection of the three phase connections and the ground connection; anda third filter path adapted to establish a conductive connection between a third phase connection of the three phase connections and the ground connection;wherein each filter path includes a series connection of (a) a pulse-proof capacitor and (b) a parallel connection of at least two Y capacitors.2. The high-frequency line filter according to claim 1 , wherein each filter path includes an ohmic damping resistor having a ...

Membrane module and method of detecting deposits in a membrane module

A device and a method for detecting deposits in a membrane module which produces a permeate and which comprises at least one permeable or semipermeable membrane layer. At least one polymer optical fiber for detecting deposits on the membrane layer is integrated in the membrane module such that the polymer optical fiber is in contact with at least one membrane layer. A method of detecting deposits in a membrane module producing a permeate and to a membrane module for producing a permeate from a feed stream of a fluid, in particular an aqueous solution, with the membrane module comprising a plurality of adjacently disposed or stacked sheets of a permeable or semipermeable membrane layer and with at least one polymer optical fiber being embedded or integrated in the membrane module, which polymer optical fiber is in contact with at least one sheet of the membrane layer.

Catalysts containing copper, zinc oxide, alumina and silica

A catalyst suitable for use in carbon oxide conversion reactions is described, said catalyst in the form of a shaped unit formed from an oxidic catalyst powder, said catalyst comprising 30-70% by weight of copper oxide, combined with zinc oxide, alumina and silica, having a Si:AI atomic ratio in the range 0.005 to 0.15:1, and having a BET surface area >105 m2/g and a copper surface area >37 m2/g catalyst. The catalyst is prepared by a co-precipitation method using an alumina sol.

Method for making copper-containing catalysts

A method for preparing a copper-containing catalyst is described comprising the steps of: (a) combining an acidic copper-containing solution with a first basic precipitant solution in a first precipitation step to form a first precipitate, (b) combining an acidic aluminium-containing solution, further comprising one or more metal compounds selected from copper compounds, zinc compounds and promoter compounds, with a second basic precipitant solution in a second precipitation step to form a second precipitate, (c) contacting the first and second precipitates together in a further mixing step to form a catalyst precursor, and (d) washing, drying and calcining the catalyst precursor to form the copper-containing catalyst, wherein a silica precursor is included in the first precipitation step, the second precipitation step or the precipitate mixing step, to provide a catalyst with a silica content, expressed as S1O2, in the range of 0.1 to 5.0 wt%.

Catalysts containing copper, zinc oxide, alumina and silica

A catalyst suitable for use in carbon oxide conversion reactions is described, said catalyst in the form of a shaped unit formed from an oxidic catalyst powder, said catalyst comprising 30- 70% by weight of copper oxide, combined with zinc oxide, alumina and silica, having a Si:AI atomic ratio in the range 0.005 to 0.15:1, and having a BET surface area > 105m2/g and a copper surface area > 37m2/g catalyst. The catalyst is prepared by a co-precipitation method using an alumina sol.

Catalysts containing copper, zinc oxide, alumina and silica

A catalyst suitable for use in carbon oxide conversion reactions is described, said catalyst in the form of a shaped unit formed from an oxidic catalyst powder, said catalyst comprising 30- 70% by weight of copper oxide, combined with zinc oxide, alumina and silica, having a Si:AI atomic ratio in the range 0.005 to 0.15:1, and having a BET surface area > 105m 2 /g and a copper surface area > 37m 2 /g catalyst. The catalyst is prepared by a co-precipitation method using an alumina sol.

Catalysts containing copper, zinc oxide, alumina and silica

A catalyst suitable for use in carbon oxide conversion reactions is described, said catalyst in the form of a shaped unit formed from an oxidic catalyst powder, said catalyst comprising 30- 70% by weight of copper oxide, combined with zinc oxide, alumina and silica, having a Si:AI atomic ratio in the range 0.005 to 0.15:1, and having a BET surface area > 105m 2 /g and a copper surface area > 37m 2 /g catalyst. The catalyst is prepared by a co-precipitation method using an alumina sol.

Catalysts containing copper, zinc oxide, alumina and silica

A catalyst suitable for use in carbon oxide conversion reactions is described, said catalyst in the form of a shaped unit formed from an oxidic catalyst powder, said catalyst comprising 30- 70% by weight of copper oxide, combined with zinc oxide, alumina and silica, having a Si:AI atomic ratio in the range 0.005 to 0.15:1, and having a BET surface area > 105m

Catalysts containing copper, zinc oxide, alumina and silica

Se describe un catalizador adecuado para usar en las reacciones de conversión de óxido de carbono, dicho catalizador está en la forma de una unidad conformada que se forma a partir de un catalizador oxídico en polvo; el catalizador comprende 30-70 % en peso de óxido de cobre, combinado con óxido de zinc, alúmina y sílice, que tiene una relación atómica Si:Al en el rango de 0,005 a 0,15:1, y que tiene un área de superficie BET ≥ 105 m2 /g y un área de superficie de cobre > 37 m2 /g de catalizador. El catalizador se prepara mediante un método de coprecipitación usando una solución de alúmina. A catalyst suitable for use in carbon oxide conversion reactions is disclosed, said catalyst being in the form of a shaped unit which is formed from a powdered oxidic catalyst; The catalyst comprises 30-70% by weight of copper oxide, combined with zinc oxide, alumina and silica, having an Si:Al atomic ratio in the range of 0.005 to 0.15:1, and having an area of BET surface area ≥ 105 m2 /g and a copper surface area > 37 m2 /g of catalyst. The catalyst is prepared by a coprecipitation method using an alumina solution.

Method for making copper-containing catalysts

A method for preparing a copper-containing catalyst is described comprising the steps of: (a) combining an acidic copper-containing solution with a basic precipitant solution in a first precipitation step to form a first precipitate, (b) combining an alkali metal aluminate solution with an acidic solution in a second precipitation step to form a second precipitate, (c) contacting the first and second precipitates together in a further precipitate mixing step to form a catalyst precursor, and (d) washing, drying and calcining the catalyst precursor to form the copper- containing catalyst, wherein at least 70% by weight of the copper in the catalyst is present in the first precipitate and a silica precursor is included in the first precipitation step, the second precipitation step or the precipitate mixing step, to provide a catalyst with a silica content, expressed as SiO 2 , in the range of 0.1 to 5.0 wt%.

Car t cell therapies with enhanced efficacy

The invention provides methods for manufacturing optimized CAR T cell therapies and uses thereof. Specifically, the invention provides parameters that can be measured, e.g ., evaluated, to manufacture CAR T cell therapies with optimized properties. The invention further provides methods of use in connection with said optimized CAR T cells.

A self-adhering sealing device with an adhesive layer arrangement

The invention is directed to a sealing device (1) comprising a waterproofing membrane (2), a sealant layer (3) covering a portion of the second primary exterior surface of the waterproofing membrane (2), and an adhesive layer (4) covering a portion of the second primary exterior surface of the waterproofing membrane (2), wherein the sealant layer (3) is composed of an adhesive sealant composition comprising 1 – 40 wt.-% of at least one elastomer, 10 – 60 wt.-% of at least one at 25 °C liquid polyolefin resin, and 5 – 65 wt.-% of at least one inert mineral filler. The invention is also directed to a method for producing a sealing device, to a method for waterproofing a substrate, and to a waterproofed substrate.

A self-adhering sealing device with an adhesive layer arrangement

The invention is directed to a sealing device (1) comprising a waterproofing membrane (2), a sealant layer (3) covering at least a portion of the second primary exterior surface of the waterproofing membrane (2) and an adhesive layer (4) covering a portion of the outer major surface of the sealant layer (3) facing away from the second primary exterior surface of the waterproofing membrane (2), wherein the sealant layer (3) is composed of an adhesive sealant composition comprising at least one elastomer, at least one at 25°C liquid polyolefin resin, and at least one inert mineral filler. The invention is also directed to a method for producing a sealing device, to a method for waterproofing a substrate, and to a waterproofed substrate.

A sealing device with a weldable fiber-based layer

The invention is directed to a sealing device (1) comprising a waterproofing layer (2) comprising at least one thermoplastic elastomer P1 and an outer layer of non-woven fabric (3) directly adhered to at least portion of the second major surface of the waterproofing layer (2) through thermal bonding, wherein the outer layer of non-woven fabric (3) comprises at least one polymer P2. The invention is also directed to a method for producing a sealing device, to the use of a layer of non-woven fabric comprising or essentially consisting of polypropylene fibers for reducing blocking of a waterproofing layer comprising at least one polypropylene-based thermoplastic elastomer, and to a method for covering a roof substrate using the sealing devices of the present invention.

Self-adhering sealing device with an adhesive layer arrangement

A sealing device including a waterproofing membrane, a sealant layer covering at least a portion of the second primary exterior surface of the waterproofing membrane and an adhesive layer covering a portion of the outer major surface of the sealant layer facing away from the second primary exterior surface of the waterproofing membrane, wherein the sealant layer is composed of an adhesive sealant composition comprising at least one elastomer, at least one at 25° C. liquid polyolefin resin, and at least one inert mineral filler. A method produces a sealing device, a method waterproofs a substrate, and a waterproofed substrate.

A sealing device with a weldable fiber-based layer

The invention is directed to a sealing device (1) comprising a waterproofing layer (2) comprising at least one thermoplastic elastomer P1 and an outer layer of non-woven fabric (3) directly adhered to at least portion of the second major surface of the waterproofing layer (2), wherein the outer layer of non-woven fabric (3) comprises at least one polymer P2. The invention is also directed to a method for producing a sealing device, to the use of a layer of non-woven fabric comprising or essentially consisting of polypropylene fibers for reducing blocking of a waterproofing layer comprising at least one propylene-based thermoplastic elastomer, and to a method for covering a roof substrate using the sealing devices of the present invention.

Senyawa-senyawa pirazina

Highly inorganically filled compositions

Compositions, methods, and apparatus for manufacturing sheets having a highly inorganically filled matrix prepared by mixing together an organic polymer binder, water, one or more inorganic aggregate materials, fibers, and optional admixtures in the correct proportions in order to form a sheet which has the desired performance criteria. The inorganically filled mixtures are formed into sheets by first extruding the mixtures and then passing the extruded materials between a set of rollers. The rolled sheets are dried in an accelerated manner to form a substantially hardened sheet, such as by heated rollers and/or a drying chamber. The inorganically filled sheets may have properties substantially similar to sheets presently made from traditional materials like paper, paperboard, polystyrene, plastic, or metal. Such sheets can be rolled, pressed, scored, perforated, folded, and glued. They have particular utility in the mass production of articles, such as food and beverage containers, and packaging materials.

Surgical suction pump assembly

A surgical suction assembly for use in closed wound surgical techniques comprising a bellows of inherently resilient material, a drainage tube for insertion in a wound, and a plug assembly for connecting the drainage tube to the bellows which incorporates a one-way valve arranged to open in response to resilient expansion of the bellows and to close in response to compression of the bellows in order to prevent accidental return to the wound of fluids which have been drained therefrom.

Administration systems for controlled drug release

Un compuesto que tiene la estructura de la fórmula (I): **(Ver fórmula)** Fórmula (I) o una sal, hidrato, o solvato farmacéuticamente aceptable del mismo; en donde: a) el agente se selecciona del grupo que consiste en un agente citostático, un agente citotóxico, una citoquina, un agente inmunosupresor, un antirreumático, un antiflogístico, un antibiótico, un analgésico, un agente virostático, un agente antiinflamatorio, un agente antimicótico, un inhibidor de factor de transcripción, un modulador del ciclo celular, un modulador de MDR, un inhibidor de proteasoma o proteasa, un modulador de apoptosis, un inhibidor enzimático, un inhibidor de transducción de señales, un inhibidor de angiogénesis, una hormona o derivado de hormona, un anticuerpo o fragmento del mismo, un péptido terapéutica o diagnósticamente activo, una sustancia radioactiva, una sustancia que emite luz, una sustancia que absorbe luz, y un derivado de cualquiera de los anteriores; **(Ver fórmula)** el espaciador está ausente, o se selecciona del grupo que consiste en **(Ver fórmula)** y **(Ver fórmula)** n es 0 o 1; X se selecciona del grupo que consiste en alquilo de C1-C18 opcionalmente sustituido en donde opcionalmente hasta seis átomos de carbono en dicho alquilo de C1-C18 están cada uno independientemente sustituido con - OCH2CH2-; alquilo de C1-C18 opcionalmente sustituido-NH-C(O)-R5- en donde opcionalmente hasta seis átomos de carbono en dicho alquilo de C1-C18 están cada uno independientemente sustituido con -OCH2CH2-; alquilo de C1-C18 opcionalmente sustituido-C(O)-NH-R5- en donde opcionalmente hasta seis átomos de carbono en dicho alquilo de C1-C18 están cada uno independientemente sustituido con -OCH2CH2-; arilo opcionalmente sustituido; heteroarilo opcionalmente sustituido; y cicloalquilo opcionalmente sustituido; R5 se selecciona del grupo que consiste en un arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, y cicloalquilo opcionalmente sustituido; Y está ausente o se ...

Combination therapies of chimeric antigen receptors and PD-1 inhibitors

Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.

Genetically altered lysm receptors with altered agonist specificity and affinity

Aspects of the present disclosure relates to genetically altered LysM receptors. In particular, the present disclosure relates to a hydrophobic patch into the LysM2 domain which can increase affinity and/or selectivity for LCOs and by replacement of regions in the LysMl domain with the corresponding regions of the LysM1 domain from a donor LysM receptor that can alter the affinity and/or selectivity for the oligosaccharide particularly for LCOs and can alter the specificity between LCO when using regions from a high affinity and specificity LCO LysM receptor such as a legume NFR1 receptor. The present disclosure also relates to genetically altering LysM receptors in plants to include a hydrophobic patch or alter the hydrophobic patch and to genetically altering LysM receptors in plants by replacement of regions in the LysM2 domain.

Genetically altered plants expressing heterologous receptors that recognize lipo-chitooligosaccharides

Aspects of the present disclosure relate to genetically modified plants comprising a nucleic acid sequence encoding a heterologous receptor polypeptide. The plants are able to recognize lipo-chitooligosaccharides (LCOs) through the heterologous receptor polypeptide. Other aspects of the present disclosure relate to methods of making such plants.

EXOPOLYSACCHARIDE RECEPTORS MODIFIED TO RECOGNIZE AND STRUCTURE THE MICROBIOTA

Los aspectos de la presente descripción se refieren a plantas modificadas genéticamente que tienen un EPR3 heterólogo o polipéptido tipo EPR3 o un EPR3 modificado o polipéptido tipo EPR3 y/o que tiene un EPR3a heterólogo o polipéptido tipo EPR3a o un EPR3a modificado o polipéptido tipo EPR3a, en donde el EPR3 o polipéptido tipo EPR3 y/o el EPR3a o polipéptido tipo EPR3a proporciona un aumento en la selectividad para un microbio comensal beneficioso en comparación con una planta tipo salvaje en las mismas condiciones. Otros aspectos de la presente descripción se refieren a métodos para elaborar tales plantas así como cultivar estas plantas genéticamente modificadas. Aspectos adicionales de la presente descripción se refieren a métodos de identificar un microbio comensal beneficioso capaz de interactuar con la microbiota de la raíz de una planta. Aspects of the present disclosure relate to genetically modified plants having a heterologous EPR3 or EPR3-like polypeptide or a modified EPR3 or EPR3-like polypeptide and/or having a heterologous EPR3a or EPR3a-like polypeptide or a modified EPR3a or EPR3a-like polypeptide, wherein the EPR3 or EPR3-like polypeptide and/or the EPR3a or EPR3a-like polypeptide provides increased selectivity for a beneficial commensal microbe compared to a wild-type plant under the same conditions. Other aspects of the present disclosure relate to methods of making such plants as well as cultivating these genetically modified plants. Additional aspects of the present disclosure relate to methods of identifying a beneficial commensal microbe capable of interacting with the root microbiota of a plant.

Combination therapies of chimeric antigen receptors adn pd-1 inhibitors

Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.

Biodegradable polymer films and sheets suitable for use as laminate coatings as well as wraps and other packaging materials

Biodegradable polymer blends suitable for laminate coatings, wraps and other packaging materials manufactured from at least one 'hard' biopolymer and at least one 'soft' biopolymer. 'Hard' biopolymers tend to be more brittle and rigid and typically have a glass transition temperature greater than about 10 °C. 'Soft' biopolymers tend to be more flexible and pliable and typically have a glass transition temperature less than about 0 °C. While hard and soft polymers each posses certain intrinsic benefits, certain blends of hard and soft polymers have been discovered which possess synergistic properties superior to those of either hard or soft polymers by themselves. Biodegradable polymers include polyesters, polyesteramides and thermoplastically processable starch. The polymer blends may optionally include an inorganic filler. Films and sheets made from the polymer blends may be textured so as to increase the bulk hand feel. Wraps will typically be manufactured so as to have good 'dead-fold' properties so as to remain in a wrapped position and not spring back to an 'unwrapped' and planar form. Laminate films will typically have good water vapor barrier properties as measured by their Water Vapor Permeability Coefficient (WVPC).

Scene analysis

Apparatus is arranged in operation to perform a method of estimating the number of individuals in a scene. The method comprises generating, for a plurality of image positions within at least a portion of a captured image of the scene, an edge correspondence value indicative of positional and angular correspondence with a representation of at least a partial outline of an individual. Analysis of the edge correspondence value is used to detect whether each of the plurality of image positions contributes to at least part of an image of an individual.

Nitric oxide synthase inhibitor phosphate salt

A compound of formula (I): namely (2S)-2-amino-4-{[2-(ethanimidoylamino)ethyl]thio}butanoic acid, compound with prosphoric acid, or a solvate or physiologically functional derivative thereof, is useful as a relatively non-hygroscopic selective inhibitor of inducible nitric oxice synthase.

Pipe rupture protection with two hydraulic actuators

Die Erfindung betrifft eine Ventilbaugruppe (20) mit einer ersten Arbeitsanschlussstelle (21), einer zweiten Arbeitsanschlussstelle (22), einer Tankanschlussstelle (23) und einer Steueranschlussstelle (24), wobei ein erstes Ventil (40) mit einer geöffneten und einer geschlossenen Stellung (44; 45) vorgesehen ist, wobei in der geöffneten Stellung Druckfluid zumindest von der ersten zur zweiten Arbeitsanschlussstelle (21; 22) leitbar ist, wobei in der geschlossenen Stellung (45) zumindest ein Fluidstrom von der ersten zur zweiten Arbeitsanschlussstelle (21; 22) gesperrt ist, wobei das erste Ventil (40) eine erste hydraulische Ansteuerung (41) aufweist, mit der es in Öffnungsrichtung verstellbar ist, wobei die erste hydraulische Ansteuerung (41) an die Steueranschlussstelle (24) fluidisch angeschlossen ist, wobei das erste Ventil (40) von einer ersten Feder (43) in Schließrichtung beaufschlagt ist. Erfindungsgemäß weist das erste Ventil (40) eine von der ersten hydraulischen Ansteuerung (41) gesondert ausgebildete zweite hydraulische Ansteuerung (42) auf, mit der es in Öffnungsrichtung verstellbar ist, wobei ein zweites Ventil (50) vorgesehen ist, mit dem die zweite hydraulische Ansteuerung (42) abhängig vom Druck an der Steueranschlussstelle (24) und abhängig vom Druck an der zweiten Arbeitsanschlussstelle (22) betätigbar ist.

Substituted benzylamines and their use for the treatment of depression

The present invention relates to certain novel benzylamine derivatives of formula (I) wherein R1 and R2, which may be the same or different, are each selected from C6-12aryl, C2-14heteroaryl, C6-12arylC1-6alkyl, C2-14heteroarylC1-6alkyl (where the alkyl, aryl or heteroaryl moiety may be optionally substituted by one or more substituents selected from C1-6alkoxy, C1-66alkyl, C3-6cycloalkyl, C4-6cycloalkenyl, C6-12aryl, C2-14heteroaryl, halogen, amino, hydroxy, haloC1-6alkyl, nitro, C1-6alkylthio, sulphonamide, C1-6alkylsulphonyl, hydroxy-C1-6alkyl, C1-6alkoxycarbonyl, carboxyl, carboxyC1-6alkyl, carboxamide and C1-6alkylcarboxamide), hydrogen, C1-6alkyl, C3-6cycloalkyl, C4-6cycloalkenyl, C2-6alkenyl, C2-6alkynyl and C1-6alkoxyC1-6alkyl (where the alkyl, cycloalkyl, cycloalkenyl, alkenyl, alkynyl, or alkoxyalkyl moieties may be optionally substituted by one or more substituents selected from amino, halogen hydroxy, C1-6alkylcarboxamide, carboxamide, carboxy C1-6alkoxycarbonyl, C1-6alkylcarboxy and carboxyC1-6alkyl) or one of R1 and R2 are as hereinbefore defined and one is hydroxy; R3 and R4, which may be the same or different, are each selected from C6-12aryl, C2-14heteroaryl, C6-12arylC1-6alkyl, C2-14heteroarylC1-6alkyl (where the alkyl, aryl or heteroaryl moiety may be optionally substituted by one or more substituents selected from C1-6alkoxy, C1-6alkyl, C3-6cycloalkyl, C4-6cycloalkenyl, C6-12aryl, C2-14heteroaryl, halogen, amino, hydroxy, haloC1-6alkyl, nitro, C1-6alkylthio, sulphonamide, C1-6alkylsulphonyl, hydroxyC1-6alkyl, C1-6alkoxycarbonyl, carboxyl, carboxyC1-6alkyl, C1-6alkylcarboxamide and carboxamide), hydrogen, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl, C1-6cycloalkenyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy-C1-6alkyl, haloC1-6alkyl, haloC2-6alkenyl, haloC2-6alkynyl, cyano, carboxyl, C1-6alkylcarboxy and carboxyC1-6alkyl (where the alkyl, cycloalkyl, cycloalkenyl, alkenyl, alkynyl, or alkoxyalkyl moieties may be optionally substituted by one or ...

Multi-pin connector

Ih-modulators

The present invention relates to the use of an Ih channel modulator in the manufacture of a medicament for use in psychiatry. To certain novel methanamine derivatives, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medical therapy, particularly for use in psychiatry.

Well completion method and apparatus

Three embodiments of an expandable screen are described. In the preferred embodiment, the base layer, filtering layer, and outer layer are joined together in a sintering furnace in the form of a flat sheet which is in turn rolled up. The layered sheet is then formed into a tube by rolling it to make a longitudinal or spiral joint which is welded with connections placed on ends. In an alternative embodiment, the base layer and filtering layer are sintered together and formed into a tube which is in turn inserted into an outer protective tube. In a third embodiment, a base pipe is perforated and its exterior surface threaded. A wire runs through the threads with a protective jacket over the underlying assembly. Upon expansion, the opening sizes remain relatively constant.

Virulence attenuated bacteria for treatment of malignant solid tumors

Housing for crimped cable connection

Delivery systems for controlled drug release

The present invention provides a compound having the structure of Formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof, for the controlled delivery and release of Agent.

Cable entry with strain relief for enclosures, or enclosures, of machinery and electrical devices

Multi-layer screen and downhole completion method

A downhole completion method and an expandable filtration apparatus are disclosed. The filter assembly comprises a plurality of layers beginning with a coated perforated base pipe. The coating reduces the force required for expansion. A drainage layer overlays the base pipe with the filtration layer above it. The drainage layer improves flow through the filtration layer and protects it from burrs in the base pipe. A filtration enhancement layer fits over the filtration layer and an outer shroud protects the assembly during run in. The assembly can be used as made or expanded downhole in one or a series of expansions.

Method and device for energy management for an electric vehicle charging system

Verfahren und Vorrichtung (116) für Energiemanagement, umfassend einen Eingang (118) für einen ersten Sensor (120), der ausgebildet ist, eine erste Messgröße (122) als Information über einen Strom zu einem Heimenergiemanagementsystem (100) zu erfassen, eine Einrichtung (124), die ausgebildet ist, abhängig von der ersten Messgröße (122) eine zweite Messgröße (126) zu bestimmen, und einen Ausgang (128), der ausgebildet ist, die zweite Messgröße (126) anstelle der ersten Messgröße (122) als Information über einen Strom zum Heimenergiemanagementsystem (100) für das Heimenergiemanagementsystem (100) auszugeben.

A sealing device with reduced blocking

The invention is directed to a sealing device (1) comprising a waterproofing membrane (2) and a protective film (3) comprising a backing layer (4), which is directly attached to at least part of the bottom surface of the waterproofing membrane (2) through thermal bonding. The invention is also directed to a method for producing a sealing device, to use of a protective film comprising a backing layer for reducing blocking of a waterproofing membrane, and to a method for covering a roof using sealing devices of the present invention.

Targeted iduronate-2-sulfatase compounds

The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, where compound is a fusion protein including iduronate-2-sulfatase and Angiopep-2. In certain embodiments, these compounds, owning to the presence of the targeting moiety can crossing the blood- brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also features methods for treating lysosomal storage disorders (e.g., mucopolysaccharidosis Type II) using such compounds.

Hydraulically settable containers

Improvements in Burners for Incandescent Gas Lights.

2856. Biheller, S. Feb. 9. Incandescent g a s lamps.-In order that the outer air supply may be directed with some force upon the lower part of the flame, the bunsen tube A is provided with a cone B, which is slit at its upper end t( allow of its being sprung upon the tube A, and is closed at its lower end to prevent air from passing be tween the tube A and the said cone. Between the cone B and the chimney or combined globe and chimney f, a glass or other burner cone or short chimney D is arranged, its upper end being so shaped that it, in conjunction with the contraction F of the chimney or globe, deflects the outer air supply upon the flame in the manner shown by the arrows. In some cases, the burner cone or short chimney D may be dispensed with.

Termination map for an aircraft

A method of creating a termination map for an aircraft over an area of interest indicating the lowest allowable flight altitude to achieve a glide path of a vehicle to a termination point of the area of interest and a map of vectors of the area of interest indicating direction towards a termination point to control an unmanned vehicle.

Method to create copper traps by modifying treatment on the dielectrics surface

Cd38 modulating antibody

The present disclosure provides antibodies that bind to human CD38. In particular, the antibodies and antigen-binding portions thereof are defined by particular functional characteristics. The antibodies present features compatible for manufacturing and can be provided as fully human antibodies (e.g., fully human monoclonal antibodies or antigen- binding fragments) that can be useful for medical methods and compositions, in particular for treating cancer.

SARM1 INHIBITORS

Drum washing machine

2-(1,2-benzisoxazol-3-yl)benzylamine derivatives

Substituted benzylamines and their use for the preparation of medicaments for treating depression

Indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (aatd)

Indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).

Sulfonylethyl phosphorodiamidates for use in the treatment of cancer

Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.

2-(1,2-benzisoxazol-3-yl)benzylamine derivatives

Connection box for electrical devices

A cable terminal or clamp

Inhibitors of sarm1

The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing neurodegenerative disease or axonal degeneration. The provided SARM1 inhibitors may reduce or inhibit binding of NAD+ by SARM1. Alternatively, provided SARM1 inhibitors bind to SARM1 within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARM1).

BENZOXAZEPINE DERIVATIVES AS O-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID RECEPTOR MODULATORS

SE REFIERE A UN DERIVADO DE BENZOXAZEPINA DE FORMULA I DONDE X ES CO, SO2, R1, R2, R3, R4 SON H, ALQUILO C1-C4, ALQUILOXI C1-C4, ALQUILOXI C1-C4-ALQUILO C1-C4, CF3, HALOGENO, NITRO, CIANO, NR8R9, NR8COR10, CONR8R9; R5, R6, R7 SON H, ALQUILO C1-C4; R8 Y R9 SON H, ALQUILO C1-C4 O FORMAN JUNTO A N UN HETEROCICO DE 5-6 MIEMBROS OPCIONALMENTE CONTIENEN O, S, NR11; R10 Y R11 SON ALQUILO C1-C4, A ES UN HETEROCICLO DE 4-7 MIEMBROS OPCIONALMENTE CONTIENE O OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C4, ALQUILOXI C1-C4, HIDROXI, HALOGENO, OXO; EXCEPTO LOS COMPUESTOS DONDE X ES CO, R1-R7 SON H; A ES (CH2)3, (CH2)4, O DONDE X ES CO, R1 ES H, R2 ES METILO; R3-R7 SON H; A ES (CH2)3; O DONDE X ES CO, R1 Y R2 SON H, R3 ES METILO, R4-R7 SON H, A ES (CH2)3; O DONDE X ES CO; R1-R3 SON H; R4 ES METILO; R5-R7 SON H; A ES (CH2)3; O DONDE X ES CO; R1-R4 SON H; R5 ES METILO; R6 Y R7 SON H; A ES (CH2)3. SON COMPUESTOS PREFERIDOS (R)-7-FLUORO-2,3,11,11a-TETRAHIDRO-1H,5H-PIRROLO[2,1-c][1,4]BENZOXAZEPIN-5-ONA; (S)-9-FLUORO-2,3,11,11a-TETRAHIDRO-1H,5H-PIRROLO[2,1-c][1,4]-BENZOXAZEPIN-5-ONA; (S)-6-FLUORO-2,3,11,11a-TETRAHIDRO-1H,5H-PIRROLO[2,1-c][1,4]-BENZOXAZEPIN-5-ONA, ENTRE OTROS. LOS COMPUESTOS SON ESTIMULANTES DEL RECEPTOR DE ACIDO O-AMINO-3-HIDROXI-5-METILISOXAZOL-4-PROPIONICO (AMPA) Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES NEUROLOGICAS, TRASTORNOS NEURODEGENERATIVOS, DISFUNCION COGNITIVA, TRASTORNOS DE LA MEMORIA, APRENDIZAJE REFERS TO A BENZOXAZEPINE DERIVATIVE OF FORMULA I WHERE X IS CO, SO2, R1, R2, R3, R4 ARE H, C1-C4 ALKYL, C1-C4 ALKYLOXY, C1-C4 ALKYLOXY, C1-C4 ALKYL, CF3, HALOGEN , NITRO, CYANE, NR8R9, NR8COR10, CONR8R9; R5, R6, R7 ARE H, C1-C4 ALKYL; R8 AND R9 ARE H, C1-C4 ALKYL OR FORM TOGETHER A HETEROZYC OF 5-6 MEMBERS OPTIONALLY CONTAIN O, S, NR11; R10 AND R11 ARE C1-C4 ALKYL, A IS A HETEROCYCLE OF 4-7 MEMBERS OPTIONALLY CONTAINS OR OPTIONALLY SUBSTITUTED WITH C1-C4 ALKYL, C1-C4 ALKYLOXY, HYDROXY, HALOGEN, OXO; EXCEPT FOR THE COMPOUNDS WHERE X IS CO, R1-R7 ARE H; A ...

Process for separating carbon particles from ash-forming component particles by flotation separation

Finos de carbón se procesas mediante separación por flotación para separar las partículas de carbón de las partículas de componente formador de ceniza. Los finos de carbón se mezclan con agua bajo condiciones de mezclado de alto cizallamiento para formar una suspensión acuosa de finos de carbón que contiene entre 15% en peso y 55% en peso de finos de carbón. La suspensión acuosa es introducida en una celda de flotación de carbón para separar las partículas de carbón de las partículas de componente formador de ceniza por separación por flotación, en donde los finos de carbón tienen un tamaño de partícula menor a 500 µm, y más preferiblemente menor a 300 µm. Las burbujas son generadas en la celda de flotación de carbón teniendo un tamaño de burbuja y cantidad de burbuja seleccionados para flotar las partículas de carbón y para formar una espuma de carbón que contiene por lo menos 15% en peso de partículas sólidas. Las partículas sólidas incluyen partículas de carbón y partículas de componente formador de ceniza. La espuma de carbón es recolectada para procesamiento adicional Coal fines are processed by flotation separation to separate the carbon particles from the ash-forming component particles. The coal fines are mixed with water under high shear mixing conditions to form an aqueous suspension of coal fines containing between 15% by weight and 55% by weight of coal fines. The aqueous suspension is introduced into a carbon flotation cell to separate the carbon particles from the ash-forming component particles by flotation separation, where the carbon fines have a particle size of less than 500 µm, and more preferably less than 300 µm. Bubbles are generated in the carbon flotation cell having a selected bubble size and bubble quantity to float the carbon particles and to form a carbon foam containing at least 15% by weight of solid particles. Solid particles include carbon particles and ash-forming component particles. Carbon foam is collected for further processing

Methods for manufacturing molded sheets having a high starch content

Low cost conformal EMI/RFI shield

An EMI/RFI shield includes a shell made from a metalized polymeric material with a shape that is predetermined to form within at least one shielded cavity. The shell has sidewalls that terminate in a flange extending at an angle to the sidewalls. The flange has a lower surface for electrically coupling the shell to a predetermined electrical potential and an upper surface for engaging a structure, preferably a protruding rib from a cover, that exerts a compressive force on the top surface for urging the lower surface into an electrical coupling arrangement with an underlying planar conductor carrying the predetermined electrical potential (e.g., ground). The lower surface can include or be placed upon a layer of electrically conductive compliant material, such as a conductive adhesive. At least one of the sidewalls can include a projecting fluted structure having a size and location that is predetermined to engage a side of the structure that exerts the compressive force.

A Lock Assembly

A lock assembly including a lock barrel adapted to be received in a lock body, the lock barrel including: a plurality of passages, at least one of which being adapted to receive a wafer having a column, one end of the column being adapted to include a key engaging surface whilst the other end is adapted to rest on a wall of the lock body, a lower pin part being received in at least one of the remainder of the passages; and a key slot being in communication with the passages and adapted to receive a key with a low cut adapted to correspond to the key engaging surface; wherein the column is configured so as to provide a gap between the key engaging surface and the low cut when the key is a bump key.

drilling

Bohrvorrichtung für Hartgestein mittels eines Fluids, aufweisend mindestens einen Bohrkopf mit Vorkammer und Mischkammer, an dem mindestens eine vorwärtsgerichtete Düse und mindestens eine rückwärtsgerichtete Düse vorhanden ist, wobei Fluid in der Mischkammer mit Abrasivstoffen versetzt wird und das Fluid mit den Abrasivstoffen aus der vorwärtsgerichteten Düse entweicht, wobei im Bereich der Vorkammer eine Teilung des Fluidstroms erfolgt, abrasivstofffreies Fluid aus den rückwärtsgerichteten Düsen austritt, eine Vermischung von Abrasivstoffen und abrasivstoffreiem Fluid in der Mischkammer erfolgt und das mit den Abrasivstoffen versetzte Fluid aus den vorwärtsgerichteten Düsen entweicht. Drilling device for hard rock by means of a fluid, comprising at least one drill head with antechamber and mixing chamber, on which at least one forward nozzle and at least one rearward nozzle is present, wherein fluid in the mixing chamber is mixed with abrasives and the fluid escapes with the abrasives from the forward nozzle in which a division of the fluid flow takes place in the region of the antechamber, abrasive-free fluid emerges from the backward nozzles, mixing of abrasives and abrasive-free fluid takes place in the mixing chamber and the fluid added with the abrasives escapes from the forward-directed nozzles.

A chair back

Un respaldo de silla compuesto por: una sección superior del respaldo (2) formada a partir de una sola banda; y una sección inferior adaptada para soportar la sección de respaldo en relación con un asiento de silla, en donde la sección inferior está formada por un par de bandas arqueadas resilientemente flexibles (4), en donde una porción de una cara superior de cada banda arqueada resilientemente flexible (4) está acoplada con una porción del lado inferior de una sección lateral de la sección de respaldo (2) para formar un reposabrazos (10). A chair back made up of: an upper section of the back (2) formed from a single band; and a lower section adapted to support the back section in relation to a chair seat, wherein the lower section is formed by a pair of resiliently flexible arched bands (4), wherein a portion of an upper face of each arched band resiliently flexible (4) is engaged with a lower side portion of a side section of the back section (2) to form an armrest (10).

Sheets having an inorganically filled matrix with a water dispersible organic polymer binder, fibrous material and an aggregate material

Lamp holder with strain relief

Multi-layer screen and downhole completion method

A downhole completion method and an expandable filtration apparatus are disclosed. The filter assembly comprises a plurality of layers beginning with a coated perforated base pipe (10). The coating (18) reduces the force required for expansion. A drainage layer (24) overlays the base pipe with the filtration layer (26) above it. The drainage layer improves flow through the filtration layer and protects it from burrs in the base pipe. A filtration enhancement layer fits (32) over the filtration layer and an outer shroud (34) protects the assembly during run in. The assembly can be used as made or expanded downhole in one or a series of expansions.

Extruded fiber reinforced cementitious products having stone-like properties and methods of making the same.

Se proporciona un producto compuesto cementoso que puede funcionar como un sustituto para piedra y materiales de superficie sólida, tales como granito, mármol y piedra diseñada. Además se divulgan métodos para manufacturar el producto compuesto cementoso usando una composición cementosa extruíble que puede ser extruida o de otra manera conformada en productos de construcción similares a piedra que pueden ser usados como un sustituto para muchos productos de piedra conocidos. En una modalidad, los productos compuestos cementosos pueden ser manufacturados de manera más económica para ser tan duros o más duros y más durables que la piedra y los materiales de superficie sólida.

C825 expressing immune cells and diagnostic uses thereof

Provided herein are compositions comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and an anti-DOTA C825 antigen binding fragment. The engineered immune cells of the present technology are configured to bind to DOTA haptens that may be complexed with a diagnostic radiopharmaceutical ( e.g ., 111 In). Also disclosed herein are methods for determinining the in vivo biodistribution, viability, and expansion of the engineered immune cells described herein.

ELECTRODE FOR ELECTROLYSIS CELLS, IN PARTICULAR FOR MERCURY CATHODE CELLS

L'INVENTION CONCERNE UNE ELECTRODE POUR CELLULES D'ELECTROLYSE, CONSTITUEE PAR L'ASSEMBLAGE PAR SOUDAGE, EN TROIS PLANS SUPERPOSES, DE CONDUCTEURS (1, 2, 3) DE SECTION RECTANGULAIRE. LA PARTIE ACTIVE DE L'ELECTRODE EST FORMEE PAR LES CONDUCTEURS 3 DU TROISIEME PLAN, QUI RECOIVENT D'UNE TIGE CENTRALE D'ALIMENTATION 4, PAR L'INTERMEDIAIRE DES CONDUCTEURS 1 ET 2, LE COURANT ELECTRIQUE AVEC UNE REPARTITION TRES UNIFORME. APPLICATION EN TANT QU'ANODE POUR DES CELLULES D'ELECTROLYSE A CATHODE DE MERCURE. THE INVENTION RELATES TO AN ELECTRODE FOR ELECTROLYSIS CELLS, CONSTITUTED BY THE WELDING ASSEMBLY, IN THREE SUPERIMPOSED PLANS, OF CONDUCTORS (1, 2, 3) OF RECTANGULAR SECTION. THE ACTIVE PART OF THE ELECTRODE IS FORMED BY THE CONDUCTORS 3 OF THE THIRD PLAN, WHICH RECEIVE FROM A CENTRAL SUPPLY ROD 4, THROUGH THE CONDUCTORS 1 AND 2, THE ELECTRIC CURRENT WITH A VERY UNIFORM DISTRIBUTION. APPLICATION AS ANODE FOR MERCURY CATHODE ELECTROLYSIS CELLS.

Combination therapies of chimeric antigen receptors and pd-1 inhibitors

Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.

Production of geranyl diphosphate-derived compounds

Disclosed is yeast cells having peroxisomally localized GPP synthase and a peroxisomally localized enzyme that converts GPP into a monoterpenoids, cannabinoids, monoterpene indole alkaloids and prenylated aromatic compounds; or a precursor therefore, which yeast cells are capable of producing improved amounts of monoterpenoids, cannabinoids, monoterpene indole alkaloids and prenylated aromatic compounds, compared with the same yeast cells where the GPP synthase and the enzyme that converts GPP are located in the cytoplasm. Further disclosed is the use of the yeast cell for producing monoterpenoids, cannabinoids, monoterpene indole alkaloids and prenylated aromatic compounds.

Amino-heteroaryl derivatives as HCN blockers

Method and device for determining the resistive component of the leakage current impedance in the alternating current network

A method for determining the resistive component of the leakage current impedance (Ri50) of a downstream branch to an alternating current network having a live phase (L), a neutral conductor (N), and a protective conductor (PE) conducted by: (a) measuring a differential current ILN between the live phase (L) and the neutral conductor (N); (b) measuring a voltage U between the live phase (L) and the neutral conductor (N) or between the live phase (L) and the protective conductor (PE); (c) correcting a phase shift between the differential current ILN and the voltage U; (d) determining several individual differential current values ILN,i and several individual voltage values Ui, the differential current values ILN,i being phase-corrected with respect to the voltage values Ui; (e) determining the effective power P from the several individual differential current values ILN,I and the several individual voltage values Ui; (f) determining the effective voltage UEff by the voltage values Ui; and (g) determining the resistive component of the leakage current impedance (Ri50).

A lock

A lock comprising a bolt mechanism comprising a rotationally mounted bolt and a rotary actuator operationally coupled to the rotationally mounted bolt, the rotary actuator being operable to rotationally withdraw the rotationally mounted bolt; and a cam mechanism independently operable of the bolt mechanism and a movably mounted interference member (in the form of a slidably mounted plate) operationally arranged with the cam mechanism, the movably mounted interference member being movable, by operation of the cam mechanism, into interference with the bolt mechanism when the rotationally mounted bolt is at least one of: (i) withdrawn, and so prevent the rotationally mounted bolt from being extended; and (ii) extended, and so prevent the rotationally mounted bolt from being withdrawn. 1/14 Ln) r- o t r 00 r-I

Surface cable plastic retainer - has strap serrations engaging slot lip to hold cable in socket with peg expanding radially to keep retainer in hole

The plastic retainer, for fixing a cable to a surface, consists of a strap (6) that folds over the cable seated in a socket (1) and passes through a slot (9) in the side of the socket. The strap's serrations (7) engage the slot's lip so that the strap holds the cable firmly into the socket. The socket has a hollow expanding peg (3) on its bottom. A pin (5) attached to the socket by a thin strip (4) can be hammered into the peg from above the socket (the strip folds up and is drawn into the peg's hole with the pin). The peg expands radially and holds the retainer in the hole in the mounting surface. The retainer is manufactured in one piece.

Modified exopolysaccharide receptors for recognizing and structuring microbiota

Aspects of the present disclosure relate to genetically altered plants having a heterologous EPR3 or EPR3-like polypeptide or a modified EPR3 or EPR3-like polypeptide and/or having a heterologous EPR3a or EPR3a-like polypeptide or a modified EPR3a or EPR3a-like polypeptide, wherein the EPR3 or EPR3-like polypeptide and/or the EPR3a or EPR3a-like polypeptide provide increased selectivity for a beneficial commensal microbe as compared to a wild-type plant under the same conditions. Other aspects of the present disclosure relate to methods of making such plants as well as cultivating these genetically altered plants. Additional aspects of the present disclosure relate to methods of identifying a beneficial commensal microbe capable of interacting with a plant root microbiota.

SIM-based positioning

In various embodiments, techniques are provided for deploying a positioning applet to a SIM (e.g., a physical SIM card or an embedded SIM (eSIM)/integrated SIM (iSIM)) via an over-the-air (OTA) update or by permanent programming (i.e. “burning in”) during manufacture. The positioning applet may run solely on a processor of the SIM, functioning without support of application, OS or baseband software executing on the CPU or baseband processor of the UE, or network deployed infrastructure support. In operation, the positioning applet collects positioning measurements from a baseband processor (e.g., a baseband chipset) of the UE (e.g., via 3GPP protocols) which are sent (e.g., as an encrypted payload) to a remote location platform that compares the positioning measurements to known positioning data in a database (e.g., a crowd sourced database) to determine UE position. The remote location platform may provide an estimated position to a designated recipient system, without involvement of the UE.

cooler arrangement

Die Erfindung betrifft eine Kühleranordnung (1), zum Kühlen eines Fluides mittels eines Luftmassenstroms (QL), wobei die Kühleranordnung wenigstens einen ersten Wärmetauscher (2) zum Übertragen einer Wärmemenge vom Fluid an den Luftmassenstrom (QL) und wenigstens einen Lüfter (3) mittels dem der Luftmassenstrom (QL) durch den ersten Wärmetauscher (2) regelbar ist, umfasst. Zwischen dem ersten Wärmetauscher (2) und dem Lüfter (3) ist wenigstens ein zweiter Wärmetauscher (4) angeordnet, welcher wenigstens beim Überschreiten einer vorgebbaren Fluidaustrittstemperatur hinter dem ersten Wärmetauscher (2), zugeschaltet wird und den Luftmassenstrom (QL) vor Eintritt in den ersten Wärmetauscher (2) vorkühlt. Des Weiteren umfasst die Erfindung eine Dampfturbinenanlage, bei der eine solche Kühleranordnung vorgesehen ist. The invention relates to a radiator arrangement (1) for cooling a fluid by means of an air mass flow (QL), wherein the radiator arrangement comprises at least a first heat exchanger (2) for transmitting an amount of heat from the fluid to the air mass flow (QL) and at least one fan (3) in which the air mass flow (QL) can be regulated by the first heat exchanger (2). At least one second heat exchanger (4) is arranged between the first heat exchanger (2) and the fan (3), which is switched on at least when a predeterminable fluid outlet temperature is exceeded behind the first heat exchanger (2) and the air mass flow (QL) before entering the first heat exchanger (2) pre-cooled. Furthermore, the invention comprises a steam turbine plant, in which such a cooler arrangement is provided.

Machining apparatus for the laser machining of a workpiece and method of the laser machining of a workpiece

According to the present application, a machining apparatus (10) for the laser machining of a workpiece (12) in a machining zone (13) is provided, having a first interface(14) for a machining laser source for generating a machining laser beam (15), a second interface (16) for a detector device (for detecting radiation (17) emitted by the machining zone (13); an outlet opening (18) for the machining laser beam (14); and first and second laser beam guiding devices (20, 22), wherein the first laser beam guiding device (20), 20a, 20b) is arranged and designed such that it guides the machining laser beam (14) to the second laser beam guiding device (22) and dynamically moves the machining laser beam (14), and the second laser beam guiding device (22) is arranged and designed such that it guides the dynamically moved machining laser beam (14) through the outlet opening (18) and at least partially guides the radiation (17) emitted by the machining zone (13) through the outlet opening to the second interface (16). Further provided is a method for the laser machining of a workpiece (12).

Selective etching of unreacted nickel after salicidation

A vehicle mounted bicycle carrier

Substituted benzylamines, their use as well as pharmaceutical formulation

Delivery systems for controlled drug release

The present invention provides a compound having the structure of Formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof, for the controlled delivery and release of Agent.

Optical device for shaping an electromagnetic wave beam and use thereof, beam treatment device and use thereof, and beam treatment method

A an optical device for shaping an electromagnetic wave beam and a use thereof, a beam treatment device and a use thereof, and a beam treatment method are provided. The optical device has an optical element positioned within beam propagation direction, and an exciter means functionally connected to the optical element for inducing an oscillation of the focal point in at least one of an x direction and an y direction of a plane perpendicular to the beam propagation direction along a focal point oscillation path.