PLIERS

A pliers includes a first member having a first head, a first handle, and a first grip. The first grip is positioned on the first handle such that an end portion of the first handle opposite the first head is exposed. The pliers also includes a second member pivotally coupled to the first member. The second member has a second head, a second handle, and a second grip. The second grip is positioned on the second handle such that an end portion of the second handle opposite the second head is exposed. Each grip includes a slot that facilitates sliding the grips onto the first and second handles over the end portions. 1. A pliers comprising:a first member including a first head and a first handle;a first grip including a first open end and a second open end, the first grip being positioned on the first handle where the first handle extends through the first open end and the second open end such that an end portion of the first handle opposite the first head is exposed;a second member pivotally coupled to the first member, the second member including a second head and a second handle; anda second grip including a first open end and a second open end, the second grip being positioned on the second handle where the second handle extends through the first and second open ends of the second grip such that an end portion of the second handle opposite the second head is exposed,wherein the first grip includes a first slot between the first and second open ends of the first grip and configured to allow the first grip to deflect to facilitate sliding the end portion of the first handle through the first and second open ends of the first grip, andwherein the second grip includes a second slot between the first and second open ends of the second grip and configured to allow the second grip to deflect to facilitate sliding the end portion of the second handle through the first and second open ends of the second grip.2. The pliers of claim 1 , wherein the first handle includes a ...

MICROPERFORATED POLYMERIC FILM AND METHODS OF MAKING AND USING THE SAME

Described herein are microperforated polymeric films comprising: opposed first and second surfaces separated by a first certain distance (); and a plurality of channels perpendicular to the first and second surfaces, wherein a first opening (-) of a channel intersects the first surface and a second opening (-) of the channel intersects the second surface; wherein the diameter of the first opening is larger than the diameter of the second opening and the second openings on the second surface are spaced apart by a second certain distance (); wherein the ratio of the first certain distance to the second certain distance is at least 0.25; and further wherein the second surface has an open area of at least 10%. Also described are methods of making and using such microperforated polymeric films. 1. A method of forming a microperforated polymeric film comprising:providing a polymeric film comprising opposed first and second surfaces and a plurality of cavities there between, wherein the plurality of cavities is open to the first surface and includes a cavity surface wherein the cavity surface intersects the first surface;providing a liquid between a support surface and the first surface; andexposing the second surface to a thermal treatment to perforate the polymeric film in the areas covering the plurality of cavities.2. The method of wherein a layer of gas separates the liquid from the apex of the cavity of at least some of the plurality of cavities.3. The method of claim 1 , wherein the fluid is water.4. The method of claim 1 , wherein the support surface is a chilled roller.5. The method of claim 1 , wherein the thermal treatment is one of: flame claim 1 , hot air claim 1 , radiant heat claim 1 , and combinations thereof.6. The method of claim 1 , wherein the support surface comprises at least one of: a texture claim 1 , a coating claim 1 , and combinations thereof.7. (canceled)8. A microperforated polymeric film comprising: comprising: (i) opposed first and second ...

BATTERY PACK

A battery pack operable to provide power to a hand-held power tool, the battery pack including a housing connectable to and supportable by the hand-held power tool; a terminal for electrically connecting the battery pack to the hand-held power tool; a cylindrical first battery cell within the housing and defining a first axis; a cylindrical second battery cell within the housing and defining a second axis; and a cylindrical third battery cell within the housing and defining a third axis. The second battery cell and the third battery cell may be arranged with the second axis and the third axis in a common plane, and the first battery cell may be arranged with the first axis non-parallel to the common plane. 1. A battery pack operable to provide power to a hand-held power tool , the battery pack comprising:a housing connectable to and supportable by the hand-held power tool;a terminal for electrically connecting the battery pack to the hand-held power tool;a cylindrical first battery cell within the housing and defining a first axis;a cylindrical second battery cell within the housing and defining a second axis; anda cylindrical third battery cell within the housing and defining a third axis;wherein the second battery cell and the third battery cell are arranged with the second axis and the third axis in a common plane, and wherein the first battery cell is arranged with the first axis non-parallel to the common plane.2. The battery pack of claim 1 , wherein the first axis intersects the common plane.3. The battery pack of claim 2 , wherein claim 2 , in the common plane claim 2 , the second battery cell and the third battery cell define an outer extent claim 2 , and wherein the first axis intersects the common plane within the outer extent.4. The battery pack of claim 1 , wherein the first axis is non-perpendicular to the common plane.5. The battery pack of claim 1 , wherein the first axis is substantially perpendicular to the common plane.6. The battery pack of claim ...

BATTERY PACK

An electrical combination. The electrical combination comprises a battery pack configured to be interfaced with a hand held power tool, a control component, and a semiconducting switch. The transfer of power from the battery pack to the hand held power tool is controlled by the control component and the switch based on one of a battery pack state of charge and a respective state of charge of one of a plurality of battery cells. A discharge current of the battery pack is regulated based on the switch being controlled into one of a first state and a second state by the control component to selectively enable the transfer power from the plurality of battery cells to the hand held power tool. 1. An electrical combination comprising: a battery pack housing connectable to and supportable by the hand held power tool,', 'a plurality of terminals configured to be interfaced with corresponding terminals of the hand held power tool, and', 'a plurality of battery cells arranged within and supported by the housing, each of the plurality of battery cells being rechargeable and having a lithium-based chemistry, each of the plurality of battery cells having a respective state of charge, the battery pack having a battery pack state of charge, power being transferable from the plurality of battery cells to the hand held power tool when the battery pack is connected to the hand held power tool;, 'a battery pack configured to be interfaced with a hand held power tool, the battery pack including'}a control component; anda semiconducting switch electrically connected to at least one of the plurality of terminals;wherein the transfer of power from the battery pack to the hand held power tool is controlled by the control component and the switch based on one of the battery pack state of charge and the respective state of charge of one of the plurality of battery cells; andwherein a discharge current of the battery pack is regulated based on the switch being controlled into one of a first ...

METHOD AND SYSTEM FOR BATTERY PROTECTION

An electrical combination. The combination comprises a hand held power tool, a battery pack and a controller. The battery pack includes a battery pack housing connectable to and supportable by the hand held power tool, a plurality of battery cells supported by the battery pack housing, each of the plurality of battery cells having a lithium-based chemistry, being individually tapped and having an individual state of charge. A communication path is provided by a battery pack sense terminal and a power tool sense terminal. The controller is operable to monitor a state of charge of a number of battery cells less than the plurality of battery cells and to generate a signal based on the monitored state of charge of the number of battery cells less than the plurality of battery cells, the signal being operable to control the operation of the hand held power tool. 1. An electrical combination comprising:a hand held power tool includinga power tool housing,a motor supported by the power tool housing, anda plurality of power tool terminals electrically connected to the motor, the plurality of power tool terminals including a power tool sense terminal; a battery pack housing connectable to and supportable by the hand held power tool,', 'a plurality of battery cells supported by the battery pack housing, each of the plurality of battery cells having a lithium-based chemistry, being individually tapped and having an individual state of charge, and', 'a plurality of battery pack terminals to electrically connect to the plurality of power tool terminals, the plurality of battery pack terminals including a battery pack sense terminal, a communication path being provided by the battery pack sense terminal and the power tool sense terminal; and, 'a battery pack including'}a controller operable to monitor a state of charge of a number of battery cells less than the plurality of battery cells and to generate a signal based on the monitored state of charge of the number of battery ...

METHOD AND SYSTEM FOR CHARGING MULTI-CELL LITHIUM-BASED BATTERY PACKS

A method and system for charging multi-cell lithium-based batteries. In some aspects, a battery charger includes a housing, at least one terminal to electrically connect to a battery pack supported by the housing, and a controller operable to provide a charging current to the battery pack through the at least one terminal. The battery pack includes a plurality of lithium-based battery cells, with each battery cell of the plurality of battery cells having an individual state of charge. The controller is operable to control the charging current being supplied to the battery pack at least in part based on the individual state of charge of at least one battery cell. 1. An electrical combination comprising:a first battery pack having a first plurality of battery cells, each cell in the first plurality of battery cells having a Lithium-based chemistry, the first battery pack having a first nominal voltage in a first nominal voltage range;a first power tool operable to be powered by the first battery pack, the first battery pack being connectable to and supportable by the first power tool;a second battery pack having a second plurality of battery cells, each cell in the second plurality of battery cells having a Lithium-based chemistry, the second battery pack having a second nominal voltage in a second nominal voltage range, the number of battery cells in the first plurality of battery cells being different than the number of battery cells in the second plurality of battery cells;a second power tool operable to be powered by the second battery pack, the second battery pack being connectable to and supportable by the second power tool; and charge the first battery pack,', 'communicate with the first battery pack,', 'determine a characteristic of the first plurality of battery cells, and', 'generate a first signal to enable the charging of the first battery pack, the first signal being generated based on the characteristic of the first plurality of battery cells when the ...

BATTERY PACK

An electrical combination including a power tool and a battery pack. The power tool includes power tool terminals. The battery pack is configured to be interfaced with the power tool. The battery pack includes a battery pack housing, at least three terminals, and a plurality of battery cells. The battery pack terminals include a positive terminal, a negative terminal, and a sense terminal. The at least three terminals are configured to be interfaced with the power tool terminals. The plurality of battery cells are arranged within and supported by the battery pack housing. Each of the battery cells has a lithium-based chemistry and a respective state of charge, and power is transferable between the battery cells and the power tool. A circuit is configured to monitor the battery cells, detect a charge imbalance among the battery cells, and prevent the battery pack from operating when the charge imbalance is detected. 1. A battery pack configured to be interfaced with an electrical device , the battery pack comprising:a battery pack housing;at least three terminals including a positive terminal, a negative terminal, and a sense terminal, the at least three terminals being configured to be interfaced with corresponding terminals of the electrical device;a plurality of battery cells arranged within and supported by the housing, each of the battery cells having a lithium-based chemistry and a respective state of charge, power being transferable between the battery cells and the electrical device; anda circuit configured to monitor the battery cells, detect a charge imbalance among the battery cells based on the respective state of charge of each of the battery cells, and disable the battery pack when the charge imbalance is detected.2. The battery pack of claim 1 , wherein the electrical device is a power tool.3. The battery pack of claim 1 , wherein the respective states of charge of the battery cells are monitored at approximately the same time.4. The battery pack of ...

PLIERS

A pliers includes a first member having a first head and a first handle. The first handle has an enlarged end portion and a grip area adjacent the enlarged end portion. At least a portion of the grip area has a smaller cross-sectional area than the enlarged end portion to define a rear lip located at an interface between the grip area and the enlarged end portion. The pliers also includes a first grip having a first open end and a second open end. The first grip is positioned on the grip area of the first handle. The first handle extends through the first open end and the second open end such that the rear lip of the first handle retains the second grip on the grip area of the first handle. 1. A pliers comprising:a first member including a first head and a first handle having an enlarged end portion and a grip area adjacent the enlarged end portion, at least a portion of the grip area having a smaller cross-sectional area than the enlarged end portion to define a rear lip located at an interface between the grip area and the enlarged end portion;a first grip including a first open end and a second open end, the first grip being positioned on the grip area of the first handle where the first handle extends through the first open end and the second open end such that the rear lip of the first handle retains the second grip on the grip area of the first handle;a second member pivotally coupled to the first member, the second member including a second head and a second handle having an enlarged end portion and a grip area adjacent the enlarged end portion, at least a portion of the grip area having a smaller cross-sectional area than the enlarged end portion to define a rear lip located at an interface between the grip area and the enlarged end portion; anda second grip including a first open end and a second open end, the second grip being positioned on the grip area of the second handle where the second handle extends through the first and second open ends of the ...

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

A method for conducting an operation including a power tool battery pack. The battery pack can include a housing, a first cell supported by the housing and having a voltage, and a second cell supported by the housing and having a voltage. The battery pack also can be connectable to a power tool and be operable to supply power to operate the power tool. The method can include discharging one of the first cell and the second cell until the voltage of the one of the first cell and the second cell is substantially equal to the voltage of the other of the first cell and the second cell. 1. A battery pack comprising:a housing connectable to and supportable by a hand held power tool;a plurality of battery cells supported by the housing, each of the plurality of battery cells having a lithium-based chemistry, each of the plurality of battery cells being cylindrical and having a cell length of less than or equal to about 70 mm;first and second terminals for electrically connecting the battery pack to the hand held power tool; anda circuit configured to monitor at least one parameter of the battery pack and control a discharge of the plurality of battery cells to produce a discharge current from the plurality of battery cells,wherein an average of the discharge current produced by the plurality of battery cells is greater than or equal to approximately 20 amps.2. The battery pack of claim 1 , wherein the lithium-based chemistry includes manganese.3. The battery pack of claim 1 , wherein each of the plurality of battery cells have a spinel chemistry.4. The battery pack of claim 1 , wherein the plurality of battery cells includes five battery cells.5. The battery pack of claim 1 , wherein each of the plurality of battery cells has a nominal voltage of approximately 3.6 volts.6. The battery pack of claim 1 , wherein each of the plurality of battery cells has an ampere-hour capacity of approximately 3.0 ampere-hours.7. The battery pack of claim 1 , wherein the circuit is ...

PRESSURE WASHER SPRAY GUN WITH MULTIPLE CHEMICAL CONTAINERS

A spray gun for use with a pressure washer includes a spray gun body, an inlet, a primary flow path for conducting a primary fluid flow, a secondary flow path for conducting a secondary fluid flow, and an inlet flow path for receiving a flow of pressurized water from the pressure washer via the inlet. The inlet flow path directs the pressurized water into the primary flow path. The spray gun further includes multiple chemical containers carried on the spray gun body, each chemical container configured to contain a different chemical, and a selector valve movable among a number of positions to fluidly couple one of the chemical containers with the secondary flow path. 1. A spray gun for use with a pressure washer , comprising:a spray gun body;an inlet;a primary flow path for conducting a primary fluid flow;a secondary flow path for conducting a secondary fluid flow;an inlet flow path for receiving a flow of pressurized water from the pressure washer via the inlet, the inlet flow path directing the pressurized water into the primary flow path;a plurality of chemical containers carried on the spray gun body; anda selector valve movable among a plurality of positions to fluidly couple one of the plurality of chemical containers with the secondary flow path.2. The spray gun of claim 1 , wherein the plurality of positions comprises:a first position, wherein when the selector valve is in the first position, a first chemical container is fluidly coupled to the secondary flow path; andan off position, wherein when the selector valve is in the off position, no chemical container is fluidly coupled to the secondary flow path.3. The spray gun of claim 2 , wherein the plurality of positions further comprises:a second position, wherein when the selector valve is in the second position, a second chemical container is fluidly coupled to the secondary flow path;wherein the off position is positioned between the first position and the second position.4. The spray gun of claim 2 , ...

LITHIUM-BASED BATTERY PACK

An electrical combination including a power tool and a battery pack. The power tool includes power tool terminals. The battery pack is configured to be interfaced with the power tool. The battery pack includes a battery pack housing, at least three terminals, and a plurality of battery cells. The battery pack terminals include a positive terminal, a negative terminal, and a sense terminal. The at least three terminals are configured to be interfaced with the power tool terminals. The plurality of battery cells are arranged within and supported by the battery pack housing. Each of the battery cells has a lithium-based chemistry and a respective state of charge, and power is transferable between the battery cells and the power tool. A circuit is configured to monitor the battery cells, detect a charge imbalance among the battery cells, and prevent the battery pack from operating when the charge imbalance is detected. 1. An electrical combination comprising:a power tool including power tool terminals; a battery pack housing,', 'at least three terminals including a positive terminal, a negative terminal, and a sense terminal, the at least three terminals configured to be interfaced with corresponding terminals of the power tool, and', 'a plurality of rechargeable battery cells arranged within and supported by the housing, each of the battery cells having a respective state of charge, power being transferable between the battery cells and the power tool;, 'a battery pack configured to be interfaced with the power tool, the battery pack including'}a balancing circuit configured to detect a charge imbalance among the battery cells based on a plurality of voltages of the plurality of rechargeable battery cells detected at substantially the same time; anda control circuit configured to balance the battery cells upon detection of the charge imbalance by the balancing circuit, the control circuit including a microprocessor.2. The electrical combination of claim 1 , wherein the ...

METHOD AND SYSTEM FOR CHARGING MULTI-CELL LITHIUM-BASED BATTERY PACKS

A method and system for charging multi-cell lithium-based batteries. In some aspects, a battery charger includes a housing, at least one terminal to electrically connect to a battery pack supported by the housing, and a controller operable to provide a charging current to the battery pack through the at least one terminal. The battery pack includes a plurality of lithium-based battery cells, with each battery cell of the plurality of battery cells having an individual state of charge. The controller is operable to control the charging current being supplied to the battery pack at least in part based on the individual state of charge of at least one battery cell. 1. An electrical combination comprising:a battery charger including a housing;at least one terminal to electrically connect to a battery pack supported by the housing, the battery pack including a plurality of lithium-based battery cells, each battery cell of the plurality of battery cells having an individual state of charge; anda controller operable to control the battery charger to supply a charging current to the battery pack through the at least one terminal, the controller being operable to control the charging current being supplied to the battery pack based at least in part on the individual state of charge of at least one battery cell, the controller being further operable to control the battery charger to supply a charging current to the battery pack by controlling the battery charger to supply the charging current in a plurality of pulses of charging current, the plurality of pulses each having a first period of time, in which the charging current is being supplied to the battery pack at a predefined amplitude, and a second period of time, in which the supply of charging current is suspended.2. The electrical combination as set forth in wherein the controller is further operable to control the charging current being supplied to the battery pack by modifying at least one of the first period of time ...

MICROPERFORATED POLYMERIC FILM AND METHODS OF MAKING AND USING THE SAME

Described herein are microperforated polymeric films comprising: opposed first and second surfaces separated by a first certain distance; and a plurality of channels perpendicular to the first and second surfaces, wherein a first opening of a channel intersects the first surface and a second opening of the channel intersects the second surface; wherein the diameter of the first opening is larger than the diameter of the second opening and the second openings on the second surface are spaced apart by a second certain distance; wherein the ratio of the first certain distance to the second certain distance is at least 0.25; and further 1. A microperforated polymeric film comprising: comprising: (i) opposed first and second surfaces separated by a first certain distance; and (ii) a plurality of channels perpendicular to the first and second surfaces , wherein a first opening of each channel intersects the first surface and a second opening of each channel intersects the second surface; wherein the diameter of the first opening is larger than the diameter of the second opening and the second openings on the second surface are spaced apart by a second certain distance; wherein the ratio of the first certain distance to the second certain distance is at least 0.25; and furtherwherein the second surface has an open area of at least 10%.2. The microperforated polymeric film of claim 1 , wherein the distance between the opposed first and second surfaces is at least 75 micrometers.3. The microperforated polymeric film according to claim 1 , wherein the microperforated polymeric film is selected from a polyolefin.4. The microperforated polymeric film according to claim 1 , wherein the channel has tapered walls.5. The microperforated polymeric film according to claim 1 , wherein the second opening is elliptical or round in shape.6. The microperforated polymeric film according to claim 1 , wherein the second openings are less than 500 microns in diameter.7. The microperforated ...

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

An electrical combination. The electrical combination comprises a battery pack configured to be interfaced with a hand held power tool, a control component, and a semiconducting switch. The transfer of power from the battery pack to the hand held power tool is controlled by the control component and the switch based on one of a battery pack state of charge and a respective state of charge of one of a plurality of battery cells. A discharge current of the battery pack is regulated based on the switch being controlled into one of a first state and a second state by the control component to selectively enable the transfer power from the plurality of battery cells to the hand held power tool. 1. An electrical combination comprising: a battery pack housing connectable to and supportable by the hand held power tool,', 'a plurality of terminals configured to be interfaced with corresponding terminals of the hand held power tool,', 'a plurality of battery cells arranged within and supported by the housing, the plurality of battery cells being configured in at least one of a series arrangement, a parallel arrangement, a partial series arrangement, and a partial parallel arrangement, each of the plurality of battery cells having a lithium-based chemistry, each of the plurality of battery cells having a respective state of charge, the battery pack having a state of charge associated with the battery cells, a discharge current capable of being provided from the plurality of battery cells to the hand held power tool, and', 'a control circuit including a printed circuit board and a flexible circuit; and, 'a battery pack configured to be interfaced with a hand held power tool, the battery pack including'}a switch electrically connected to at least one of the terminals;wherein the discharge current is provided from the battery pack to the hand held power tool and is controlled by the control circuit and the switch based on one of the battery pack state of charge and the respective ...

METHOD AND SYSTEM FOR BATTERY PROTECTION

An electrical combination. The combination comprises a hand held power tool, a battery pack and a controller. The battery pack includes a battery pack housing connectable to and supportable by the hand held power tool, a plurality of battery cells supported by the battery pack housing, each of the plurality of battery cells having a lithium-based chemistry, being individually tapped and having an individual state of charge. A communication path is provided by a battery pack sense terminal and a power tool sense terminal. The controller is operable to monitor a state of charge of a number of battery cells less than the plurality of battery cells and to generate a signal based on the monitored state of charge of the number of battery cells less than the plurality of battery cells, the signal being operable to control the operation of the hand held power tool. 1. A method of operating an electrical combination , the electrical combination including a battery pack configured to supply power to a cordless power tool having a motor , the method comprising: a terminal configured to provide a communication path between the battery pack and the cordless power tool, and', 'a battery pack housing connectable to and supportable by the cordless power tool;, 'monitoring, with a controller, a respective battery cell state of charge of a plurality of battery cells included in the battery pack, the plurality of battery cells operable to supply a battery pack discharge current to the motor of the cordless power tool, each of the battery cells being individually tapped, the battery pack includingcontrolling, with the controller and by communicating a signal via the terminal, a switch to be in a conducting state to enable the supply of discharge current from the battery pack to the motor, the controller being electrically connected to the switch; andmodifying operation of the battery pack, with the controller, by causing the switch to move from the conducting state to a non-conducting ...

BATTERY PACK

An electrical combination. The electrical combination comprises a battery pack configured to be interfaced with a hand held power tool, a control component, and a semiconducting switch. The transfer of power from the battery pack to the hand held power tool is controlled by the control component and the switch based on one of a battery pack state of charge and a respective state of charge of one of a plurality of battery cells. A discharge current of the battery pack is regulated based on the switch being controlled into one of a first state and a second state by the control component to selectively enable the transfer power from the plurality of battery cells to the hand held power tool. 1. An electrical combination comprising: a battery pack housing connectable to and supportable by the hand held power tool,', 'a plurality of terminals configured to be interfaced with corresponding terminals of the hand held power tool, and', 'a plurality of battery cells arranged within and supported by the housing, each of the plurality of battery cells having a lithium-based chemistry, each of the plurality of battery cells having a respective state of charge, the battery pack having a state of charge associated with the battery cells, a discharge current capable of being provided from the plurality of battery cells to the hand held power tool when the battery pack is connected to the hand held power tool;, 'a battery pack configured to be interfaced with a hand held power tool, the battery pack including'}a control component; anda semiconducting switch electrically connected to at least one of the plurality of terminals;wherein the discharge current is provided from the battery pack to the hand held power tool and is controlled by the control component and the switch based on a state of charge associated with fewer than all of the battery cells; andwherein the discharge current is regulated based on the switch being controlled into one of a first state and a second state by ...

Bio-mechanically compatible 3D-printed intervertebral disc

The interface device includes a first surface that matches the surface morphology of the corresponding artificial disc and a second surface that matches the surface morphology of the corresponding endplate of the vertebrae. The interface device of the present disclosure can be fabricated using the three-dimensional printing technology.

LITHIUM-BASED BATTERY PACK

An electrical combination including a power tool and a battery pack. The power tool includes power tool terminals. The battery pack is configured to be interfaced with the power tool. The battery pack includes a battery pack housing, at least three terminals, and a plurality of battery cells. The battery pack terminals include a positive terminal, a negative terminal, and a sense terminal. The at least three terminals are configured to be interfaced with the power tool terminals. The plurality of battery cells are arranged within and supported by the battery pack housing. Each of the battery cells has a lithium-based chemistry and a respective state of charge, and power is transferable between the battery cells and the power tool. A circuit is configured to monitor the battery cells, detect a charge imbalance among the battery cells, and prevent the battery pack from operating when the charge imbalance is detected. 1. A battery pack configured to be interfaced with an electrical device , the battery pack comprising:a battery pack housing;a positive terminal, a negative terminal, and a sense terminal configured to be interfaced with corresponding terminals of the electrical device;a plurality of battery cells arranged within the housing, each of the plurality of battery cells having a lithium-based chemistry and a respective state of charge, power being transferable between the plurality of battery cells and the electrical device;means for monitoring the plurality of battery cells;means for detecting a charge imbalance among the plurality of battery cells based on the respective state of charge of each of the plurality of battery cells; anda microprocessor programmed to disable the battery pack when the charge imbalance is detected;wherein the microprocessor is further programmed to identify an imbalanced battery cell having a high state of charge relative to a state of charge of another battery cell of the plurality of battery cells;wherein the microprocessor is ...

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

A method for conducting an operation including a power tool battery pack. The battery pack can include a housing, a first cell supported by the housing and having a voltage, and a second cell supported by the housing and having a voltage. The battery pack also can be connectable to a power tool and be operable to supply power to operate the power tool. The method can include discharging one of the first cell and the second cell until the voltage of the one of the first cell and the second cell is substantially equal to the voltage of the other of the first cell and the second cell. 1. A method of operating a battery pack , the method comprising: a plurality of battery cells supported within the housing, each of the plurality of battery cells having a lithium-based chemistry, each of the plurality of battery cells having a cell width and a cell length, the cell length being at least about two times the cell width, and', 'first and second terminals for electrically connecting the battery pack to the hand held power tool; and, 'coupling a housing of the battery pack to a hand held power tool to support the battery pack on the hand held power tool, the battery pack including'}controlling, with a circuit, a discharge of the plurality of battery cells to produce a discharge current from the plurality of battery cells, an average of the discharge current produced by the plurality of battery cells being greater than or equal to approximately 20 amps.2. The method of claim 1 , wherein each of the plurality of battery cells are cylindrical.3. The method of claim 1 , wherein the plurality of battery cells are connected in a combined series-parallel configuration.4. The method of claim 1 , wherein the cell length is between about two and about 2.7 times the cell width.5. The method of claim 1 , wherein the battery pack has an ampere-hour capacity of at least about 3.0 ampere-hours.6. The method of claim 1 , wherein the battery pack has an ampere-hour capacity of up to about 3.0 ...

METHOD FOR FAST-DETECTION OF PEAK FAULT CURRENT

A system and method for quickly detecting fault current on a power line in an electrical power distribution network. A switch assembly includes a detecting circuit for quickly detecting the fault current on the power line. The circuit includes a Rogowski coil wrapped around the power line that provides an output measurement signal that is proportional to a change in the current flow on the line, and a passive integrator responsive to the output measurement signal from the Rogowski coil that integrates the output measurement signal over time. The circuit also includes an amplifier responsive to and amplifying the integrated output measurement signal and a microcontroller responsive to the amplified output measurement signal that calculates the current flow on the line using the amplified output measurement signal. A current transformer harvests energy from the power line to power the circuit when the fault current is occurring. 1. A current detecting circuit for measuring current flow on an electrical line , the circuit comprising:a Rogowski coil wrapped around the line and providing an output measurement signal that is proportional to a change in current flow on the line;a passive integrator responsive to the output signal from the Rogowski coil, the passive integrator integrating the output signal over time;an amplifier responsive to and amplifying the integrated output measurement signal; anda microcontroller responsive to the amplified and integrated output measurement signal, the microcontroller calculating the current flow on the line using the amplified output measurement signal.2. The circuit according to wherein the circuit is part of a switch assembly in a power distribution network.3. The circuit according to wherein the circuit detects fault current on a power line in the network.4. The circuit according to wherein the switch assembly includes a vacuum interrupter.5. The circuit according to wherein the switch assembly is part of a self-powered ...

METHOD AND SYSTEM FOR BATTERY PROTECTION

An electrical combination. The combination comprises a hand held power tool, a battery pack and a controller. The battery pack includes a battery pack housing connectable to and supportable by the hand held power tool, a plurality of battery cells supported by the battery pack housing, each of the plurality of battery cells having a lithium-based chemistry, being individually tapped and having an individual state of charge. A communication path is provided by a battery pack sense terminal and a power tool sense terminal. The controller is operable to monitor a state of charge of a number of battery cells less than the plurality of battery cells and to generate a signal based on the monitored state of charge of the number of battery cells less than the plurality of battery cells, the signal being operable to control the operation of the hand held power tool. 1. An electrical combination comprising:a battery pack configured to supply power to a cordless power tool having a motor, the battery pack including a plurality of battery cells operable to supply a battery pack discharge current to the motor of the cordless power tool, each of the battery cells being individually tapped and having a battery cell state of charge;a switch operable to be alternately positioned in one of a conducting state and a non-conducting state, the switch further operable to enable the supply of discharge current from the battery pack to the motor when the switch is positioned in the conducting state and operable to interrupt the supply of discharge current from the battery pack to the motor when the switch is positioned in the non-conducting state; anda controller electrically connected to the switch, operable to monitor the respective battery cell state of charge of each of the battery cells, operable to control operation of the battery pack, and operable to control the positioning of the switch, the controller including a microcontroller;wherein the controller modifies operation of the ...

BATTERY PACK

An electrical combination including a power tool and a battery pack. The power tool includes power tool terminals. The battery pack is configured to be interfaced with the power tool. The battery pack includes a battery pack housing, at least three terminals, and a plurality of battery cells. The battery pack terminals include a positive terminal, a negative terminal, and a sense terminal. The at least three terminals are configured to be interfaced with the power tool terminals. The plurality of battery cells are arranged within and supported by the battery pack housing. Each of the battery cells has a lithium-based chemistry and a respective state of charge, and power is transferable between the battery cells and the power tool. A circuit is configured to monitor the battery cells, detect a charge imbalance among the battery cells, and prevent the battery pack from operating when the charge imbalance is detected. 1. A battery pack configured to be interfaced with an electrical device , the battery pack comprising:a battery pack housing;a positive terminal, a negative terminal, and a sense terminal configured to be interfaced with corresponding terminals of the electrical device;a plurality of battery cells arranged within the housing, each of the plurality of battery cells having a lithium-based chemistry and a respective state of charge, power being transferable between the plurality of battery cells and the electrical device, wherein the plurality of battery cells is monitored and a charge imbalance among the plurality of battery cells is detected based on the respective state of charge of each of the plurality of battery cells; anda microprocessor programmed to disable the battery pack when the charge imbalance is detected.2. The battery pack of claim 1 , wherein the electrical device is a power tool.3. The battery pack of claim 1 , wherein the respective states of charge of each of the plurality of battery cells are monitored at approximately the same time.4. ...

Anti-Viral Compounds

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

An electrical combination. The electrical combination comprises a battery pack configured to be interfaced with a hand held power tool, a control component, and a semiconducting switch. The transfer of power from the battery pack to the hand held power tool is controlled by the control component and the switch based on one of a battery pack state of charge and a respective state of charge of one of a plurality of battery cells. A discharge current of the battery pack is regulated based on the switch being controlled into one of a first state and a second state by the control component to selectively enable the transfer power from the plurality of battery cells to the hand held power tool. 1. An electrical combination comprising: a battery pack housing connectable to and supportable by the hand held power tool,', 'a plurality of terminals configured to be interfaced with corresponding terminals of the hand held power tool, and', 'a plurality of battery cells arranged within and supported by the housing, each of the plurality of battery cells having a lithium-based chemistry, each of the plurality of battery cells having a respective state of charge, the battery pack having a state of charge associated with the battery cells, a discharge current capable of being provided from the plurality of battery cells to the hand held power tool;, 'a battery pack configured to be interfaced with a hand held power tool, the battery pack including'}a control circuit including a printed circuit board and a flexible circuit board; anda switch electrically connected to at least one of the terminals;wherein the discharge current is provided from the battery pack to the hand held power tool and is controlled by the control circuit and the switch based on one of the battery pack state of charge and the respective state of charge of one of the plurality of battery cells; andwherein the discharge current is regulated based on the switch being controlled selectively into one of a first ...

Roller Guard with Discharge for Friction-Driven Sweep Conveyor

We disclose a roller guard with discharge for friction-driven sweep conveyors. This disclosure limits the introduction of particulate matter into the interface between a driven roller and an inner surface of a continuous conveyor belt. The roller guard assembly is mounted between an upper belt portion and a lower belt portion near the drive roller and has a retaining wall member oriented at an angle that is neither parallel with nor at a right angle to the longitudinal axis of the belt and at such an angle that particulates carried on the inner surface of the lower belt portion are directed toward the discharge aperture in the first sidewall.

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

A method for conducting an operation including a power tool battery pack. The battery pack can include a housing, a first cell supported by the housing and having a voltage, and a second cell supported by the housing and having a voltage. The battery pack also can be connectable to a power tool and be operable to supply power to operate the power tool. The method can include discharging one of the first cell and the second cell until the voltage of the one of the first cell and the second cell is substantially equal to the voltage of the other of the first cell and the second cell. 1. A battery pack comprising:a housing connectable to and supportable by a hand held power tool;a plurality of battery cells supported within the housing, each of the plurality of battery cells having a lithium-based chemistry, each of the plurality of battery cells having a cell length of greater than or equal to about 60 mm;first and second terminals for electrically connecting the battery pack to the hand held power tool; anda circuit configured to control a discharge of the plurality of battery cells to produce a discharge current from the plurality of battery cells,wherein an average of the discharge current produced by the plurality of battery cells is greater than or equal to approximately 20 amps.2. The battery pack of claim 1 , wherein the plurality of battery cells are connected in a combined series-parallel configuration.3. The battery pack of claim 1 , wherein each of the plurality of battery cells are cylindrical.4. The battery pack of claim 1 , wherein the battery pack has an ampere-hour capacity of at least 3.0 ampere-hours.5. The battery pack of claim 1 , wherein each of the plurality of battery cells has a cell length of less than about 70 mm.6. The battery pack of claim 1 , wherein each of the plurality of battery cells has a cell length of about 65 mm.7. The battery pack of claim 1 , wherein the circuit is configured to control a field-effect transistor (“FET”) to ...

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

A method for conducting an operation including a power tool battery pack. The battery pack can include a housing, a first cell supported by the housing and having a voltage, and a second cell supported by the housing and having a voltage. The battery pack also can be connectable to a power tool and be operable to supply power to operate the power tool. The method can include discharging one of the first cell and the second cell until the voltage of the one of the first cell and the second cell is substantially equal to the voltage of the other of the first cell and the second cell. 1. A battery pack comprising:a housing connectable to and supportable by a hand held power tool;a plurality of battery cells supported within the housing, each of the plurality of battery cells having a lithium-based chemistry, each of the plurality of battery cells having a cell width and a cell length, the cell length being at least about two times the cell width;first and second terminals for electrically connecting the battery pack to the hand held power tool; anda circuit configured to control a discharge of the plurality of battery cells to produce a discharge current from the plurality of battery cells, an average of the discharge current produced by the plurality of battery cells being greater than or equal to approximately 20 amps.2. The battery pack of claim 1 , wherein each of the plurality of battery cells are cylindrical.3. The battery pack of claim 1 , wherein the plurality of battery cells are connected in a combined series-parallel configuration.4. The battery pack of claim 1 , wherein the cell length is between about two and about 2.7 times the cell width.5. The battery pack of claim 1 , wherein the battery pack has an ampere-hour capacity of at least about 3.0 ampere-hours.6. The battery pack of claim 1 , wherein the battery pack has an ampere-hour capacity of up to about 3.0 ampere-hours.7. The battery pack of claim 1 , wherein the cell length is between about 60 mm and ...

METHOD AND SYSTEM FOR BATTERY PROTECTION

An electrical combination. The combination comprises a hand held power tool, a battery pack and a controller. The battery pack includes a battery pack housing connectable to and supportable by the hand held power tool, a plurality of battery cells supported by the battery pack housing, each of the plurality of battery cells having a lithium-based chemistry, being individually tapped and having an individual state of charge. A communication path is provided by a battery pack sense terminal and a power tool sense terminal. The controller is operable to monitor a state of charge of a number of battery cells less than the plurality of battery cells and to generate a signal based on the monitored state of charge of the number of battery cells less than the plurality of battery cells, the signal being operable to control the operation of the hand held power tool. 1. An electrical combination comprising:a battery pack configured to supply power to a cordless power tool having a motor, the battery pack including a plurality of battery cells operable to supply a battery pack discharge current to the motor of the cordless power tool, each of the battery cells being individually tapped and having a battery cell state of charge, the battery pack including a terminal configured to provide a communication path between the battery pack and the cordless power tool;a switch operable to be alternately positioned in one of a conducting state and a non-conducting state, the switch further operable to enable the supply of discharge current from the battery pack to the motor when the switch is positioned in the conducting state and operable to interrupt the supply of discharge current from the battery pack to the motor when the switch is positioned in the non-conducting state; anda controller electrically connected to the switch, operable to monitor the respective battery cell state of charge of each of the battery cells, operable to control operation of the battery pack, and operable to ...

PLIERS

A pliers includes a first member and a second member pivotally coupled to the first member. The first member and the second member each include a head and a handle having a recessed area with a non-circular cross-sectional shape and an exposed end portion adjacent the recessed area. The recessed area is bounded by a forward lip and a rear lip. The forward lip has a cross-sectional area not greater than a cross-sectional area of a portion of the handle adjacent the forward lip and opposite the recessed area. The pliers also includes a first grip positioned on the recessed area of the handle of the first member and a second grip positioned on the recessed area of the handle of the second member. The end portions of the handles are made of metal. 1. A pliers comprising:a first member including a first head and a first handle having a recessed area with a non-circular cross-sectional shape and an exposed end portion adjacent the recessed area, the recessed area bounded by a forward lip and a rear lip, the forward lip having a cross-sectional area not greater than a cross-sectional area of a portion of the first handle adjacent the forward lip and opposite the recessed area;a first grip positioned on the recessed area of the first handle;a second member pivotally coupled to the first member, the second member including a second head and a second handle having a recessed area with a non-circular cross-sectional shape and an exposed end portion adjacent the recessed area, the recessed area bounded by a forward lip and a rear lip, the forward lip having a cross-sectional area not greater than a cross-sectional area of a portion of the second handle adjacent the forward lip and opposite the recessed area; anda second grip positioned on the recessed area of the second handle,wherein the end portions of the first and second handles are made of metal.2. The pliers of claim 1 , wherein the end portion of the first handle extends from the rear lip to a distal end claim 1 ,wherein ...

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

A method for conducting an operation including a power tool battery pack. The battery pack can include a housing, a first cell supported by the housing and having a voltage, and a second cell supported by the housing and having a voltage. The battery pack also can be connectable to a power tool and be operable to supply power to operate the power tool. The method can include discharging one of the first cell and the second cell until the voltage of the one of the first cell and the second cell is substantially equal to the voltage of the other of the first cell and the second cell. 1. A battery pack comprising:a housing connectable to and supportable by a hand held power tool;a plurality of battery cells supported within the housing, the plurality of battery cells connected in a combined series-parallel configuration, each of the plurality of battery cells having a lithium-based chemistry, each of the plurality of battery cells being cylindrical and having a cell diameter and a cell length, the cell length being at least about two times the cell diameter;first and second terminals for electrically connecting the battery pack to the hand held power tool; anda circuit configured to control a discharge of the plurality of battery cells to produce a discharge current from the plurality of battery cells, an average of the discharge current produced by the plurality of battery cells being greater than or equal to approximately 20 amps.2. The battery pack of claim 1 , wherein the lithium-based chemistry includes manganese.3. The battery pack of claim 1 , wherein the cell length is between about two and about 2.7 times the cell diameter.4. The battery pack of claim 1 , wherein the battery pack has an ampere-hour capacity of at least 3.0 ampere-hours.5. The battery pack of claim 1 , wherein the cell length is between about 60 mm and about 70 mm.6. The battery pack of claim 1 , wherein the cell length is about 65 mm.7. The battery pack of claim 1 , wherein the circuit is ...

METHOD AND SYSTEM FOR BATTERY PROTECTION

An electrical combination. The combination comprises a hand held power tool, a battery pack and a controller. The battery pack includes a battery pack housing connectable to and supportable by the hand held power tool, a plurality of battery cells supported by the battery pack housing, each of the plurality of battery cells having a lithium-based chemistry, being individually tapped and having an individual state of charge. A communication path is provided by a battery pack sense terminal and a power tool sense terminal. The controller is operable to monitor a state of charge of a number of battery cells less than the plurality of battery cells and to generate a signal based on the monitored state of charge of the number of battery cells less than the plurality of battery cells, the signal being operable to control the operation of the hand held power tool. 1. An electrical combination comprising:a battery pack configured to supply power to a cordless power tool having a motor, the battery pack including a plurality of battery cells operable to supply a battery pack discharge current to the motor of the cordless power tool, each of the battery cells being individually tapped and having a battery cell state of charge, the battery pack including a terminal configured to provide a communication path between the battery pack and the cordless power tool;a switch operable to be alternately positioned in one of a conducting state and a non-conducting state, the switch further operable to enable the supply of discharge current from the battery pack to the motor when the switch is positioned in the conducting state and operable to interrupt the supply of discharge current from the battery pack to the motor when the switch is positioned in the non-conducting state; anda controller electrically connected to the switch, operable to monitor the respective battery cell state of charge of each of the battery cells, operable to control operation of the battery pack, and operable to ...

LITHIUM-BASED BATTERY PACK

An electrical combination including a power tool and a battery pack. The power tool includes power tool terminals. The battery pack is configured to be interfaced with the power tool. The battery pack includes a battery pack housing, at least three terminals, and a plurality of battery cells. The battery pack terminals include a positive terminal, a negative terminal, and a sense terminal. The at least three terminals are configured to be interfaced with the power tool terminals. The plurality of battery cells are arranged within and supported by the battery pack housing. Each of the battery cells has a lithium-based chemistry and a respective state of charge, and power is transferable between the battery cells and the power tool. A circuit is configured to monitor the battery cells, detect a charge imbalance among the battery cells, and prevent the battery pack from operating when the charge imbalance is detected. 1. An electrical combination comprising:a power tool including power tool terminals; a battery pack housing,', 'at least three terminals including a positive terminal, a negative terminal, and a sense terminal, the at least three terminals configured to be interfaced with corresponding terminals of the power tool, and', 'a plurality of rechargeable battery cells arranged within and supported by the housing, each of the battery cells having a respective state of charge, power being transferable between the battery cells and the power tool;, 'a battery pack configured to be interfaced with the power tool, the battery pack including'}a balancing circuit configured to detect a charge imbalance among the battery cells based on a plurality of voltages of the plurality of rechargeable battery cells detected at substantially the same time; anda control circuit configured to initiate a controlled discharging process to discharge at least one of the battery cells whose present state of charge is high relative to a present state of charge of another of the battery ...

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

A method for conducting an operation including a power tool battery pack. The battery pack can include a housing, a first cell supported by the housing and having a voltage, and a second cell supported by the housing and having a voltage. The battery pack also can be connectable to a power tool and be operable to supply power to operate the power tool. The method can include discharging one of the first cell and the second cell until the voltage of the one of the first cell and the second cell is substantially equal to the voltage of the other of the first cell and the second cell. 1. (canceled)2. A battery pack comprising:a housing connectable to and supportable by a hand held power tool;a plurality of battery cells supported within the housing, the plurality of battery cells connected in a combined series-parallel configuration, each of the plurality of battery cells having a lithium-based chemistry;first and second terminals for electrically connecting the battery pack to the hand held power tool; anda circuit configured to control a discharge of the plurality of battery cells to produce a discharge current from the plurality of battery cells,wherein an average of the discharge current produced by the plurality of battery cells is greater than or equal to approximately 20 amps, andwherein the battery pack has an ampere-hour capacity of approximately 3.0 ampere-hours.3. The battery pack of claim 2 , wherein the lithium-based chemistry includes manganese.4. The battery pack of claim 2 , wherein each of the plurality of battery cells has a spinel chemistry.5. The battery pack of claim 2 , wherein each of the plurality of battery cells has a nominal voltage of approximately 3.6 volts.6. The battery pack of claim 2 , wherein the circuit is configured to protect at least one component of the battery pack.7. The battery pack of claim 2 , wherein the circuit is configured to control a field-effect transistor (“FET”) to control the discharge of the plurality of battery ...

METHOD AND SYSTEM FOR BATTERY PROTECTION

An electrical combination. The combination comprises a hand held power tool, a battery pack and a controller. The battery pack includes a battery pack housing connectable to and supportable by the hand held power tool, a plurality of battery cells supported by the battery pack housing, each of the plurality of battery cells having a lithium-based chemistry, being individually tapped and having an individual state of charge. A communication path is provided by a battery pack sense terminal and a power tool sense terminal. The controller is operable to monitor a state of charge of a number of battery cells less than the plurality of battery cells and to generate a signal based on the monitored state of charge of the number of battery cells less than the plurality of battery cells, the signal being operable to control the operation of the hand held power tool. 1. An electrical combination comprising: a power tool housing,', 'a motor supported by the power tool housing, and', 'a plurality of power tool terminals electrically connected to the motor, the plurality of power tool terminals including a power tool sense terminal;, 'a hand held power tool including'} a battery pack housing connectable to and supportable by the hand held power tool,', a cylindrical first battery cell within the battery pack housing and defining a first axis, and', 'a cylindrical second battery cell within the battery pack housing and defining a second axis,', 'wherein the first battery cell and the second battery cell are arranged with the first axis substantially perpendicular to the second axis, and, 'a plurality of battery cells supported by the battery pack housing, each of the plurality of battery cells being individually tapped and having an individual state of charge, the plurality of battery cells including'}, 'a plurality of battery pack terminals to electrically connect to the plurality of power tool terminals, the plurality of battery pack terminals including a battery pack sense ...

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

A method for conducting an operation including a power tool battery pack. The battery pack can include a housing, a first cell supported by the housing and having a voltage, and a second cell supported by the housing and having a voltage. The battery pack also can be connectable to a power tool and be operable to supply power to operate the power tool. The method can include discharging one of the first cell and the second cell until the voltage of the one of the first cell and the second cell is substantially equal to the voltage of the other of the first cell and the second cell.

PLIERS

A pliers includes a first member having a first head and a first handle, and a second member having a second head and a second handle. Each of the handles includes a recessed grip area bounded by a forward lip and a rear lip. The rear lip has a cross-sectional area not greater than a cross-sectional area of a portion of the handle adjacent the rear lip and opposite the grip area. The pliers also includes a first grip positioned on the grip area of the first handle and a second grip positioned on the grip area of the second handle. 1. A pliers comprising:a first member including a first head and a first handle having a recessed grip area bounded by a forward lip and a rear lip, the rear lip having a cross-sectional area not greater than a cross-sectional area of a portion of the first handle adjacent the rear lip and opposite the grip area;a first grip positioned on the grip area of the first handle;a second member pivotally coupled to the first member, the second member including a second head and a second handle having a recessed grip area bounded by a forward lip and a rear lip, the rear lip having a cross-sectional area not greater than a cross-sectional area of a portion of the second handle adjacent the rear lip and opposite the grip area; anda second grip positioned on the grip area of the second handle.2. The pliers of claim 1 ,wherein the first grip is generally flush with the portion of the first handle adjacent the rear lip such that there is a generally smooth transition between an exterior of the first grip and the portion of the first handle adjacent the rear lip in a longitudinal direction of the first handle, andwherein the second grip is generally flush with the portion of the second handle adjacent the rear lip such that there is a generally smooth transition between an exterior of the second grip and the portion of the second handle adjacent the rear lip in a longitudinal direction of the second handle.3. The pliers of claim 1 , wherein the first ...

BATTERY PACK

An electrical combination including a power tool and a battery pack. The power tool includes power tool terminals. The battery pack is configured to be interfaced with the power tool. The battery pack includes a battery pack housing, at least three terminals, and a plurality of battery cells. The battery pack terminals include a positive terminal, a negative terminal, and a sense terminal. The at least three terminals are configured to be interfaced with the power tool terminals. The plurality of battery cells are arranged within and supported by the battery pack housing. Each of the battery cells has a lithium-based chemistry and a respective state of charge, and power is transferable between the battery cells and the power tool. A circuit is configured to monitor the battery cells, detect a charge imbalance among the battery cells, and prevent the battery pack from operating when the charge imbalance is detected. 1. A battery pack configured to be interfaced with an electrical device , the battery pack comprising:a battery pack housing;a positive terminal, a negative terminal, and a sense terminal configured to be interfaced with corresponding terminals of the electrical device;a plurality of battery cells arranged within the housing, each of the plurality of battery cells having a lithium-based chemistry and a respective state of charge, power being transferable between the plurality of battery cells and the electrical device; anda microprocessor programmed to monitor the plurality of battery cells, detect a charge imbalance among the plurality of battery cells based on the respective state of charge of each of the plurality of battery cells, and disable the battery pack by controlling a switch when the charge imbalance is detected.2. The battery pack of claim 1 , wherein the electrical device is a power tool.3. The battery pack of claim 1 , wherein the respective states of charge of each of the plurality of battery cells are monitored at approximately the same ...

Systems and methods to provide lubricant to a bearing

Systems and methods to help provide lubricant to a bearing in a compressor are disclosed. The embodiments disclosed herein generally are directed to systems and methods to provide a lubricant flow to the bearing, where the lubricant flow relies on the rotation of a shaft of the compressor, so that the lubricant flow can be independent of a power supply.

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

An electrical combination. The electrical combination comprises a battery pack configured to be interfaced with a hand held power tool, a control component, and a semiconducting switch. The transfer of power from the battery pack to the hand held power tool is controlled by the control component and the switch based on one of a battery pack state of charge and a respective state of charge of one of a plurality of battery cells. A discharge current of the battery pack is regulated based on the switch being controlled into one of a first state and a second state by the control component to selectively enable the transfer power from the plurality of battery cells to the hand held power tool. 1. An electrical combination comprising: a battery pack housing connectable to and supportable by the hand held power tool,', 'a plurality of terminals configured to be interfaced with corresponding terminals of the hand held power tool, and', 'a plurality of battery cells arranged within and supported by the housing, the plurality of battery cells being configured in at least one of a series arrangement, a parallel arrangement, a partial series arrangement, and a partial parallel arrangement, each of the plurality of battery cells having a lithium-based chemistry, each of the plurality of battery cells having a respective state of charge, the battery pack having a state of charge associated with the battery cells, a discharge current capable of being provided from the plurality of battery cells to the hand held power tool;, 'a battery pack configured to be interfaced with a hand held power tool, the battery pack including'}a control component; anda switch electrically connected to at least one of the terminals;wherein the discharge current is provided from the battery pack to the hand held power tool and is controlled by the control component and the switch based on one of the battery pack state of charge and the respective state of charge of one of the plurality of battery cells; ...

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

A method for conducting an operation including a power tool battery pack. The battery pack can include a housing, a first cell supported by the housing and having a voltage, and a second cell supported by the housing and having a voltage. The battery pack also can be connectable to a power tool and be operable to supply power to operate the power tool. The method can include discharging one of the first cell and the second cell until the voltage of the one of the first cell and the second cell is substantially equal to the voltage of the other of the first cell and the second cell. 1. A battery pack comprising:a housing connectable to and supportable by a hand held power tool;a plurality of battery cells supported within the housing, the plurality of battery cells connected in a combined series-parallel configuration, each of the plurality of battery cells having a lithium-based chemistry;first and second terminals for electrically connecting the battery pack to the hand held power tool; anda circuit configured to control a discharge of the plurality of battery cells to produce a discharge current from the plurality of battery cells,wherein an average of the discharge current produced by the plurality of battery cells is greater than or equal to approximately 20 amps.2. The battery pack of claim 1 , wherein the lithium-based chemistry includes manganese.3. The battery pack of claim 1 , wherein each of the plurality of battery cells has a spinel chemistry.4. The battery pack of claim 1 , wherein each of the plurality of battery cells has a nominal voltage of approximately 3.6 volts.5. The battery pack of claim 1 , wherein the battery pack has an ampere-hour capacity of at least 3.0 ampere-hours.6. The battery pack of claim 5 , wherein the battery pack has an ampere-hour capacity of approximately 3.0 ampere-hours.7. The battery pack of claim 1 , wherein the circuit is configured to control a field-effect transistor (“FET”) to control the discharge of the plurality of ...

METHOD AND SYSTEM FOR BATTERY PROTECTION

An electrical combination. The combination comprises a hand held power tool, a battery pack and a controller. The battery pack includes a battery pack housing connectable to and supportable by the hand held power tool, a plurality of battery cells supported by the battery pack housing, each of the plurality of battery cells having a lithium-based chemistry, being individually tapped and having an individual state of charge. A communication path is provided by a battery pack sense terminal and a power tool sense terminal. The controller is operable to monitor a state of charge of a number of battery cells less than the plurality of battery cells and to generate a signal based on the monitored state of charge of the number of battery cells less than the plurality of battery cells, the signal being operable to control the operation of the hand held power tool. 1. A battery pack operable to provide power to a hand-held power tool , the battery pack comprising:a housing connectable to and supportable by the hand-held power tool;a terminal for electrically connecting the battery pack to the hand-held power tool;a cylindrical first battery cell within the housing and defining a first axis;a cylindrical second battery cell within the housing and defining a second axis;a cylindrical third battery cell within the housing and defining a third axis;a cylindrical fourth battery cell within the housing and defining a fourth axis; anda cylindrical fifth battery cell within the housing and defining a fifth axis,wherein the first battery cell and the second battery cell are arranged with the first axis and the second axis in a common plane, the third axis, the fourth axis, and the fifth axis are each substantially perpendicular to the first battery cell and the second battery cell, the third battery cell is adjacent to the fourth battery cell, the fourth battery cell is adjacent to the fifth battery cell, and the fifth battery cell is adjacent to the third battery cell, the third ...

METHOD AND SYSTEM FOR CHARGING MULTI-CELL LITHIUM-BASED BATTERY PACKS

A method and system for charging multi-cell lithium-based batteries. In some aspects, a battery charger includes a housing, at least one terminal to electrically connect to a battery pack supported by the housing, and a controller operable to provide a charging current to the battery pack through the at least one terminal. The battery pack includes a plurality of lithium-based battery cells, with each battery cell of the plurality of battery cells having an individual state of charge. The controller is operable to control the charging current being supplied to the battery pack at least in part based on the individual state of charge of at least one battery cell. 1. An electrical combination comprising:a battery charger including a housing;at least one terminal to electrically connect to a battery pack supported by the housing, the battery pack including a plurality of lithium-based battery cells, each battery cell of the plurality of battery cells having an individual state of charge; anda controller operable to control the battery charger to supply a charging current to the battery pack through the at least one terminal, the controller being operable to control the charging current being supplied to the battery pack based at least in part on the individual state of charge of at least one battery cell, the controller being further operable to control the battery charger to supply the charging current to the battery pack by controlling the battery charger to supply the charging current in a plurality of pulses of charging current, the plurality of pulses each having a first period of time, in which the charging current is being supplied to the battery pack at a predefined amplitude, and a second period of time, in which the supply of charging current is suspended, the controller being operable to control the charging current being supplied to the battery pack by modifying the first period of time and controlling the second period of time to be constant.2. The ...

METHOD AND SYSTEM FOR CHARGING MULTI-CELL LITHIUM-BASED BATTERY PACKS

A method and system for charging multi-cell lithium-based batteries. In some aspects, a battery charger includes a housing, at least one terminal to electrically connect to a battery pack supported by the housing, and a controller operable to provide a charging current to the battery pack through the at least one terminal. The battery pack includes a plurality of lithium-based battery cells, with each battery cell of the plurality of battery cells having an individual state of charge. The controller is operable to control the charging current being supplied to the battery pack at least in part based on the individual state of charge of at least one battery cell. 1. An electrical combination comprising:a battery charger operable to provide a charging current;a battery pack electrically connectable to the battery charger over a positive terminal and a negative terminal, the battery pack including a plurality of lithium-based battery cells and a control circuit, each of the plurality of battery cells having an individual state of charge, the battery pack operable to communicate with the battery charger in a serial manner over a sense terminal, wherein the battery pack communicates information related to the individual state of charge of at least one of the plurality of battery cells to the battery charger; anda switch operable to control the charging current from the battery charger to the battery pack based on the information related to the individual state of charge of the at least one of the plurality of battery cells, the switch operable to be controlled between an ON state and an OFF state to control the charging current.2. The electrical combination of claim 1 , wherein the switch includes a field-effect transistor (“FET”).3. The electrical combination of claim 2 , wherein the control circuit is operable to control the switch.4. The electrical combination of claim 1 , wherein control circuit includes a microcontroller.5. The electrical combination of claim 1 , ...

METHOD AND SYSTEM FOR CHARGING MULTI-CELL LITHIUM-BASED BATTERY PACKS

A method and system for charging multi-cell lithium-based batteries. In some aspects, a battery charger includes a housing, at least one terminal to electrically connect to a battery pack supported by the housing, and a controller operable to provide a charging current to the battery pack through the at least one terminal. The battery pack includes a plurality of lithium-based battery cells, with each battery cell of the plurality of battery cells having an individual state of charge. The controller is operable to control the charging current being supplied to the battery pack at least in part based on the individual state of charge of at least one battery cell. 1. A battery charger , comprising:a housing;at least two terminals including a power terminal and a sense terminal to electrically connect to a power tool battery pack supported by the housing, the power tool battery pack including a plurality of lithium-based battery cells, each battery cell of the plurality of battery cells having an individual state of charge; and supply a charging current to the power tool battery pack through the power terminal,', 'receive an individual state of charge of at least one of the plurality of battery cells over the sense terminal,', 'control the charging current being supplied to the power tool battery pack based at least in part on a comparison of the individual state of charge of the at least one of the plurality of battery cells to at least one state of charge threshold value,', 'control the charging current being supplied to the power tool battery pack by controlling the battery charger to supply the charging current in a plurality of pulses, the plurality of pulses each having a first period of time during which the charging current is being supplied to the power tool battery pack at a predefined amplitude, and a second period of time during which the supply of charging current is suspended, and', 'control the charging current being supplied to the power tool battery ...

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Method and apparatus for control of drive systems for cycle based processes

An apparatus for controlling operation of a processing machine has a computer (18) preferably with a computer aided design program (16) configurable to model a kinematic velocity profile of a point of interest on a machine to be controlled. A graphical user interface (28) on the computer enables an operator to select desired velocity points for a motor drive (40) controlling motion of the point on the machine. A curve fit is applied to the velocity points to realize a desired velocity profile for the motor drive and the point on the machine. The desired velocity profile is then integrated and scaled in order to obtain a scaled velocity profile that realizes an actual, or target displacement of the point as dictated by operation of the machine. By controlling operation of elements of a machine with velocity profiles, coordination of associated elements and points on the machine can be visualized by an operator selecting the velocity points for each drive of the machine. A method for implementing same is also disclosed.

Curable sealant composition

A UV curable, flexible, paintable composition is disclosed. The disclosed composition has enhanced durability, thick and thin film adhesion, resistance to mold growth and dimensional changes while reducing solvent emissions. The disclosed composition reduces, if not eliminates, runs and drips during the thermal bake cycles which are associated with using conventional compositions in automotive applications.

Inhibitors of protein farnesyltransferase and squalene synthase

The present invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, which are useful in inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

Anti-viral compounds to treat hcv infection

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus (HCV) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-Viral Compounds

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

ANTI-VIRAL COMPOUNDS Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Hepatitis c inhibitors and uses thereof

This disclosure relates to: (a) compounds and salts thereof that, inter alia , inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Antiviral compounds

Un compuesto, un tautómero del compuesto, o una sal aceptable desde el punto de vista farmacéutico delcompuesto o tautómero, en donde el compuesto se selecciona del grupo que consiste en:un compuesto que tiene la Fórmula II:en donde:R6 se selecciona del grupo que consiste en hidrógeno y ciano;R8 se selecciona del grupo que consiste en hidrógeno y arilalquilo;R25 se selecciona del grupo que consiste en hidrógeno y alquilo;R37 se selecciona del grupo que consiste en hidrógeno, alquilo, hidroxialquilo, y cicloalquilo;R42 se selecciona del grupo que consiste en arilsulfanilo, heteroarilsulfanilo, y ariloxi; en donde R42 estásustituido en forma opcional con uno o más sustituyentes seleccionados en forma independiente de R46;R46 es uno o más sustituyentes seleccionados del grupo que consiste en hidrógeno, hidroxi, amino,halógeno, dialquilamino, y alcoxicarbonilamino;R70 se selecciona del grupo que consiste en arilo, y heterociclo; en donde R70 está sustituido en formaopcional con R75;R75 es uno o más sustituyentes seleccionados en forma independiente del grupo que consiste enhidrógeno, halógeno, alcoxi, ciano, alquilo, haloalquilo, y arilo.un compuesto que tiene la Fórmula III: A compound, a tautomer of the compound, or a pharmaceutically acceptable salt of the compound or tautomer, wherein the compound is selected from the group consisting of: a compound having Formula II: wherein: R6 is selected from the group consisting of hydrogen and cyano; R8 is selected from the group consisting of hydrogen and arylalkyl; R25 is selected from the group consisting of hydrogen and alkyl; R37 is selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, and cycloalkyl; R42 is selects from the group consisting of arylsulfanyl, heteroarylsulfanyl, and aryloxy; wherein R42 is optionally substituted with one or more substituents independently selected from R46; R46 is one or more substituents selected from the group consisting of hydrogen, hydroxy, amino, halogen, dialkylamino, ...

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-Viral Compounds

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-Viral Compounds

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Antiviral compounds

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus (HCV) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

An antiviral 1-phenyl-2,5-dibenzimidazol-5-yl-pyrrolidine derivative

Compounds effective in inhibiting replication of Hepatitis C virus (HCV) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus (HCV) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

Anti-viral compounds

This invention relates to processes and intermediates for making compounds which are effective in inhibiting replication of Hepatitis C virus (HCV).

Anti-Viral Compounds

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Hepatitis C inhibitors and uses thereof

This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Hepatitis C inhibitors and uses thereof

This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Hepatitis C inhibitors and uses thereof

This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Anti-viral compounds

Hepatitis C virus inhibitors

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Hepatitis C virus inhibitors

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus ('HCV') or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Trisubstituted heterocycles as replication inhibitors of hepatitis C virus HCV

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Antiviral compounds

El compuesto {(2S,3R)-1-[(2S)-2-{5-[(2R,5R)-1-{3,5-difluoro-4-[4-(4-fluorofenil)piperidin-1-il]fenil}-5-(6-fluoro-2- {(2S)-1-[N-(metoxicarbonil)-O-metil-L-treonil]pirrolidin-2-il}-1H-benzimidazol-5-il)pirrolidin-2-il]-6-fluoro-1H-benzimidazol-2il}pirrolidin-1-il]-3-metoxi-1-oxobutan-2-il}carbamato de metilo, o una de sus sales farmacéuticamente aceptables, para su uso en un método de tratamiento de un paciente infectado con el genotipo 1 del VHC, comprendiendo dicho método la administración de una cantidad eficaz de dicho compuesto a dicho paciente. The compound {(2S, 3R) -1 - [(2S) -2- {5 - [(2R, 5R) -1- {3,5-difluoro-4- [4- (4-fluorophenyl) piperidin-1 -yl] phenyl} -5- (6-fluoro-2- {(2S) -1- [N- (methoxycarbonyl) -O-methyl-L-threonyl] pyrrolidin-2-yl} -1H-benzimidazol-5- il) methyl pyrrolidin-2-yl] -6-fluoro-1H-benzimidazol-2-yl} pyrrolidin-1-yl] -3-methoxy-1-oxobutan-2-yl} carbamate, or a pharmaceutically acceptable salt thereof, for use in a method of treating a patient infected with HCV genotype 1, said method comprising administering an effective amount of said compound to said patient.

Heterocyclic compounds as hepatitis C virus (HCV) inhibitors

Un compuesto de Fórmula IB, o una de sus sales farmacéuticamente aceptables,**Fórmula** donde: X es heterociclo de 3 a 12 miembros, y está opcionalmente sustituido con uno o más RA; cada uno de L1 y L2 se selecciona independientemente entre enlace; o alquileno C1-C6, alquileno C2-C6 o alquinileno C2-C6, cada uno de los cuales está, independientemente, sustituido en cada caso opcionalmente con uno o más RL; L3 es enlace o -LS-K-LS'-, donde K se selecciona entre enlace, -O-, -S-, -N(RB)-, -C(O)-, -S(O)2-, -S(O)-, -OS(O)-, -OS(O)2-, -S(O)O-, -S(O)O-, -C(O)O-, -OC(O)-, -OC(O)O-, -C(O)N(RB)-, -N(RB)C(O)-, -N(RB)C(O)O-, -OC(O)N(RB)-, -N(RB)S(O)-, -N(RB)S(O)2-, -S(O)N(RB)-, -S(O)2N(RB)-, -C(O)N(RB)C(O)-, -N(RB)C(O)N(RB'), -N(RB)SO2N(RB')-, o -N(RB)S(O)N(RB')-; A es**Fórmula** o**Fórmula** y está opcionalmente sustituido con uno o más RA;**Fórmula** B es**Fórmula** o**Fórmula** y está opcionalmente sustituido con uno o más RA; Z1 se selecciona independientemente en cada caso entre O, S, NH o CH2; Z2 se selecciona independientemente en cada caso entre N o CH; D es carbociclo C3-C1 o heterociclo de 3 a 12 miembros, que está sustituido con J y opcionalmente sustituido con uno o más RA, donde J es carbociclo C3-C1 o heterociclo de 3 a 12 miembros y está opcionalmente sustituido con uno o más RA, o J es -SF5; cada RC' se selecciona independientemente entre RC; cada RD se selecciona independientemente entre RD; R2 y R5, tomados junto con los átomos a los que están unidos, forman un heterociclo de 3 a 12 miembros que está opcionalmente sustituido con uno o más RA; y R9 y R12, tomados junto con los átomos a los que están unidos, forman un heterociclo de 3 a 12 miembros que está opcionalmente sustituido con uno o más RA; T se selecciona independientemente en cada caso entre enlace, -LS-, -LS-M-LS'-, o -LS-M-LS'-M'-LS"-, donde cada M y M' se selecciona independientemente en cada caso entre enlace, -O-, -S-, -N(RB)-, -C(O)-, -S(O)2-, -S(O)-, -OS ...

Anti-viral compounds

本發明描述一種可有效抑制C型肝炎病毒(「HCV」)複製之化合物。本發明亦關於製備該等化合物之方法，包含該等化合物之組合物，及使用該等化合物來治療HCV感染之方法。

Anti-viral compounds to treat hcv infection.

Se describen compuestos efectivos para inhibir la replicación del Virus de Hepatitis C ("VHC"). Esta invención también se refiere a procedimientos para elaborar dichos compuestos, a composiciones que comprenden dichos compuestos, y a métodos para utilizar dichos compuestos para tratar infección por VHC.

Anti-viral compounds to treat hcv infection

Anti-viral compounds to treat hcv infection

Anti-viral compounds to treat hcv infection

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Antiviral compounds to treat HCV infection

Un compuesto o una de sus sales farmacéuticamente aceptables, donde dicho compuesto tiene la Fórmula IB **Fórmula** donde: X es carbociclo C3-C12, y está opcionalmente sustituido con uno o más Ra; cada RC se selecciona independientemente entre Rc; cada RD se selecciona independientemente entre Rd; R2 y R5, tomados junto con los átomos a los que están unidos, forma un heterociclo de 3 a 12 miembros que está opcionalmente sustituido con uno o más Ra; y R9 y R12, tomados junto con los átomos a los que están unidos, forma un heterociclo de 3 a 12 miembros que está opcionalmente sustituido con uno o más Ra; cada Rd se selecciona independientemente en cada caso entre hidrógeno o Ra; R6 se selecciona independientemente en cada caso entre halógeno, nitro, oxo, fosfonoxi, fosfono, tioxo, ciano, o -Ls-Re, donde dos Ra adyacentes, tomados junto con los átomos a los que están unidos, y cualesquiera átomos situados entre los átomos a los que están unidos, puede formar opcionalmente un carbociclo o heterociclo; Rb se selecciona independientemente en cada caso entre hidrógeno, o alquilo C1-C9, alquenilo C2-C6 o alquinilo C2-C6, cada uno de los cuales está, de manera independiente, sustituido en cada caso de manera opcional con uno o más sustituyentes seleccionados entre halógeno, hidroxi, mercapto, amino, carboxi, nitro, oxo, fosfonoxi, fosfono, tioxo, formilo, ciano o carbociclo o heterociclo de 3 a 6 miembros; o carbociclo o heterociclo de 3 a 6 miembros; donde cada carbociclo o heterociclo de 3 a 6 miembros en Rc está, de manera independiente, sustituido en cada caso de manera opcional con uno o más sustituyentes seleccionados entre halógeno, hidroxi, mercapto, amino, carboxi, nitro, oxo, fosfonoxi, fosfono, tioxo, formilo, ciano, alquilo C1-C9, alquenilo C2-6, alquenilo C2-C6, haloalquilo C1-C9, haloalquenilo C2-C6 o haloalquinilo C2-C6; Rc se selecciona independientemente en cada caso entre hidrógeno, halógeno, hidroxi, mercapto, amino, carboxi, nitro, oxo, fosfonoxi, fosfono ...

Anti-viral compounds

Compounds for Formula I effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. (see formula I)

Anti-viral compounds.

Anti-viral compounds to treat hcv infection hcv

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Hepatitis C virus inhibitors

Compound derived from ((4-terbutylphenyl) pyrrolidin-2,5-diyl) bis (4,1-phenylene) substituted, vhc replication inhibitor; pharmaceutical composition; Useful in the treatment of a vhc infection.

LA PRESENTE INVENCIÓN REIVINDICA EL COMPUESTO (2S,2'S)- 1,1 '-((2S,2'S)-2,2-(4,4-((2S,5S)- 1-(4-TERT-BULILFENIL)PIRROLIDIN-2,5-DIIL)BIS(4, 1 -FENILEN))BIS(AZANDIIL)BIS(OXOMETILEN) BIS(PIRROLIDIN-2, 1 -DIIL))BIS (3-METIL-I-OXOBUTAN-2,1-DIIL)DICARBAMATO DE DIMETILO ÚTIL PARA INHIBIR LA REPLICACIÓN DEL VIRUS DE LA HEPATITIS C (VHC). ESTA INVENCIÓN TAMBIÉN SE RELACIONA CON UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE DICHO COMPUESTO, ÚTIL PARA TRATAR INFECCIONES POR VHC" THIS INVENTION REIVINDICATES THE COMPOUND (2S, 2'S) - 1,1 '- ((2S, 2'S) -2,2- (4,4 - ((2S, 5S) - 1- (4-TERT-BULILFENIL) PIRROLIDIN -2,5-DIIL) BIS (4, 1-PHENYLENE)) BIS (AZANDIIL) BIS (OXOMETILEN) BIS (PIRROLIDIN-2, 1 -DIIL)) BIS (3-METIL-I-OXOBUTAN-2,1-DIIL ) DIMETHYL DICARBAMATE USEFUL TO INHIBIT THE REPLICATION OF HEPATITIS C VIRUS (HCV). THIS INVENTION IS ALSO RELATED TO A PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND, USEFUL TO TREAT HCV INFECTIONS "

ANTIVIRAL COMPOUNDS

La presente invención se refiere a compuestos de fórmula Ien donde X es carbociclo de C3-C12 o heterociclo de 3 a 12 miembros, L1 y L2 se seleccionan en forma independiente entre sí entre una unión; o alquileno de C1-C6, entre otros; L3 es una unión o -LS-K-LS'-; A y B son en forma independiente entre sí carbociclo de C3-C12 o heterociclo de 3 a 12 miembros, y están sustituidos en forma independiente entre sí con uno o más RA; D es carbociclo de C3-C12 o heterociclo de 3 a 12 miembros, y está opcionalmente sustituido con uno o más RA; o D es hidrógeno o RA; Y se selecciona entre -T'-C(R1R2)N(R5)-T-RD, -T'-C(R3R4)C(R6R7)-T-RD, -LK-T-RD, o -LK-E; y Z se selecciona entre -T'-C(R8R9)N(R12)-T-RD, -T'-C(R10R11)C(R13R14)-T-RD, -LK-T-RD, o -LK-E. Dichos compuestos resultan eficaces para inhibir la replicación del virus de la hepatitis C ("HCV"). Esta invención también se relaciona con procesos de elaboración de tales compuestos y composiciones farmacéuticas que los comprenden, para tratar una infección por HCV.

SUSPENSION VIRUS INHIBITIONS C

Περιγράφονται ενώσεις αποτελεσματικές στην αναστολή της αντιγραφής του ιού της Ηπατίτιδας C ("ΗCV"). Η παρούσα εφεύρεση αναφέρεται επίσης σε διεργασίες δημιουργίας αυτών των ενώσεων, σε συνθέσεις περιλαμβάνουσες αυτές τις ενώσεις και σε μεθόδους χρήσεως αυτών των ενώσεων για την αγωγή της μολύνσεως από ΗCV. Compounds effective in inhibiting hepatitis C virus replication ("HCV") are described. The present invention also relates to processes for the production of these compounds, to compositions comprising these compounds, and to methods of using these compounds for the treatment of HCV infection.

Heterocyclic compounds as inhibitors of hepatitis C virus (HCV)

Effective compounds for inhibiting hepatitis c virus ("HCV") replication

La presente invención se refiere al compuesto (2S,2'S)-1,1'-((2S,2'S)-2,2'-(4,4'-((2S,5S)-1-(4-tert-butilfenil)pirrolidin-2,5-diil)bis(4,1-fenilen))bis(azandiil)bis(oxometilen)bis(pirrolidin-2,1-diil))bis(3-metil-1-oxobutan-2,1-diil)dicarbamato de dimetilo y composicionfarmaceuticaque lo comprende Los compuestos de la presente invención son eficaces para inhibir la replicación del virus de la hepatitis C (“HCV”).

ANTIVIRAL COMPOUNDS

Compuestos eficaces para inhibir la replicación del virus de la hepatitis C ("HCV"). Esta invención también se relaciona con procesos de elaboración de tales compuestos, con composiciones que comprenden a dichos compuestos y con métodos de uso de dichos compuestos para tratar una infección por HCV.

Trisubstituted heterocycles as replication inhibitors of hepatitis c virus hcv hcv