Methods of wet etching a self-assembled monolayer patterned substrate and metal patterned articles

Method of patterning a substrate are described including a method of providing a substrate comprising a metalized surface having a self-assembled monolayer patterned region and unpatterned region; and wet etching the metalized surface in a liquid etchant agitated with bubbling gas to remove metal from the unpatterned regions to form a metal pattern. Also described are metal patterned article including an article comprising a substrate and an etched microcontact printed metal pattern disposed on the substrate wherein the pattern has a thickness of at least 100 nanometers and a pattern feature uniformity of at least 50% for an area of at least 25 cm 2 .

Distributed power conditioning with dc-dc converters implemented in heterogeneous integrated circuit

A flat panel active electronically scanned array (AESA) ( 1 ) includes heterogeneous integrated circuit DC-DC voltage converters ( 3 ) periodically placed on array elements ( 2 ). A heterogeneous integrated circuit ( 100, 400, 500, 600 ) includes a voltage converter ( 101 ) configured to receive an input voltage (V I ), and to convert the input voltage to an output voltage (V O ) that is different from the input voltage, the voltage converter ( 101 ) comprising an analog and/or digital PWM circuit ( 104 ). The heterogeneous integrated circuit ( 100, 400, 500, 600 ) also includes a feedback circuit ( 103 ) configured to receive the output voltage (V O ), and to generate a control signal used to vary a pulse width of a PWM signal generated by the analog and/or digital PWM circuit ( 104 ). The digital PWM circuit ( 104 ) is implemented in a heterogeneous integrated circuit ( 100, 400, 500, 600 ) fabricated on a common substrate ( 606 ) using CMOS and GaN fabrication processes.

ROLL-TO-ROLL DIGITAL PHOTOLITHOGRAPHY

A system for making flexible circuit films includes an inelastic conveyor, a web handling apparatus configured to pass a flexible substrate around the inelastic conveyor, an image acquisition apparatus configured to measure positions of a first set of alignment marks on the flexible substrate at a first conveyor location, an exposure apparatus configured to patternwise expose a photosensitive material on the flexible substrate at a second conveyor location, and an image processor configured to receive the measured positions of the first set of alignment marks, and to compare the measured positions with reference positions of the first set of alignment marks. The exposure apparatus is configured to patternwise expose the photosensitive material based on the comparison between the measured positions and the reference positions. 1. A roll-to-roll photolithography system , comprising:an inelastic conveyor, wherein the inelastic conveyor consists of a single roller;a web handling apparatus configured to pass a flexible substrate around the conveyor such that the substrate and the conveyor move together at least from a first conveyor location to a second conveyor location;an image acquisition apparatus configured to measure positions of a first set of alignment marks on the substrate at the first conveyor location;an exposure apparatus configured to patternwise expose a photosensitive material on the flexible substrate at the second conveyor location; andan image processor configured to receive the measured positions of the first set of alignment marks, and to compare the measured positions with reference positions of the first set of alignment marks;wherein the exposure apparatus is configured to patternwise expose the photosensitive material based on the comparison between the measured positions and the reference positions.2. The system of claim 1 , wherein the image acquisition apparatus is configured to measure the positions of the first set of alignment marks while ...

Process for Improving the Rheological Properties of an Aqueous Dispersion

A process for improving the rheological properties of an aqueous dispersion comprising adding a rheology modifier to the aqueous dispersion, and then adding a water soluble synthetic polymer flocculant to the aqueous dispersion. The rheology modifier may be selected from the group consisting of natural polymers, semi-natural polymers, synthetic materials and combinations thereof. The water soluble synthetic polymer flocculant may be selected from the group consisting of water soluble anionic polymers, cationic polymers, amphoteric polymers, nonionic polymers, and combinations thereof.

Stent

A stent comprising a stent body and a plurality of cells is disclosed. Each cell includes two structural members extending in an undulating pattern. Each structural member includes a plurality of cell segments defining a plurality of peaks and valleys therebetween. A first segment and a second segment defining a first peak, the second segment and a third segment defining a first valley, the third segment and a fourth segment defining a second peak, the fourth segment and a fifth segment defining a second valley, the fifth segment and a sixth segment defining a third peak. The first peak, the second peak and the first valley include a first radius of curvature. The third peak and the second valley include a second radius of curvature. The first radius of curvature is larger than the second radius of curvature.

HYDROPHILIC GEL MATERIALS AND METHODS OF MAKING

The present disclosure describes articles, such as medical articles, containing a substrate having disposed thereon a hydrophilic gel material (e.g., a shaped hydrophilic gel material or a coating of a hydrophilic gel material) and methods for making such articles. Methods are provided for making hydrophilic gel materials from a precursor composition that contains a polar solvent and a polymerizable material that is miscible with the polar solvent. 1. A method of making an article comprising a substrate and a hydrophilic gel material adhered thereto , the method comprising: (a) at least 10 weight percent polar solvent based on a total weight of the precursor composition; and', '(b) polymerizable material capable of free-radical polymerization and having an average number of ethylenically unsaturated groups per molecule equal to at least 1.2, wherein the polymerizable material is miscible with the polar solvent;, 'providing a precursor composition comprisingproviding a mold having at least two separate wells;adding the precursor composition to the mold, the precursor composition being positioned in at least a portion of at least two separate wells;providing a substrate and positioning the substrate to at least partially contact the precursor composition; andexposing the precursor composition within the wells to radiation to at least partially polymerize the polymerizable material and to form a first swollen shaped hydrophilic gel material adhered to the substrate.2. The method of claim 1 , wherein the polar solvent comprises water; and the precursor composition comprises no greater than 90 weight percent polymerizable material based on the total weight of the precursor composition claim 1 , wherein the polymerizable material comprises a poly(alkylene oxide (meth)acrylate) having at least 2 (meth)acryloyl groups and having at least 5 alkylene oxide units.3. A method of making an article comprising a substrate and a hydrophilic gel material adhered thereto claim 1 , ...

System and method for measuring separation rate of water from water-in-crude oil emulsions

System and method relates to measuring separation rate of water from water-in-crude oil emulsions at elevated temperature. The system includes an electrolytic interface (conductivity) cell comprising a plurality of capacitance/conductance probes disposed at different heights in a fluid stream disposed within the interface cell and an analyzer. Logic of the analyzer determines the separation rate based on signals received from the plurality of capacitance/conductance probes in the interface cell that are coupled to monitor the fluid stream. Methods for making and using the system are also disclosed.

Apparatus for combining planting implements

An apparatus for combining planting implements enables an operator of a tractor to use both a conventional cultivating implement and a conventional broadcasting implement simultaneously. The apparatus is rigidly affixed to a conventional cultivating implement and comprises a support frame, a pair of brackets, and a connection bar. In combination, the support frame, pair of brackets, and connection bar provide a three-point connection whereby a conventional broadcasting implement may be attached thereto, thus enabling an operator of a tractor to use both a conventional cultivating implement and a conventional broadcasting implement simultaneously. In operation, at least a portion of the conventional cultivating implement is disposed behind the conventional broadcasting implement when the conventional broadcasting implement is attached to the support frame, thereby allowing simultaneous cultivation and broadcasting of constituents.

Vascular Stent

A medical stent includes a stent body defining a longitudinal axis and opposed longitudinal ends, and being adapted to expand from an initial condition to an expanded condition. The stent body includes a plurality of longitudinal cells. The longitudinal cells include opposed end cells and at least one intermediate cell disposed between the end cells. Each longitudinal cell has first and second structural members extending in an undulating pattern about the longitudinal axis. Intermediate connectors interconnect the first and second structural members of the at least one intermediate cell and end connectors interconnecting the first and second structural members of at least one end cell. The number of end connectors is greater than the number of intermediate connectors, and may double the number of end connectors.

Stent

A stent comprising a stent body and a plurality of cells is disclosed. The stent body defines a length. Each cell includes two structural members extending in an undulating pattern. Each structural member includes a plurality of cell segments defining a plurality of nodes therebetween. At least one node includes a non-constant radius of curvature.

High speed, high efficiency, high power rf pulse modulating integrated switch

Embodiments of a drain modulator that uses high power switch sensing to control active pulldown are generally described herein. In some embodiments, a logic and sense module is arranged to receive a control signal for controlling an on and an off state of an input of a switch to turn a high power voltage at an output of the switch on and off. A pullup module and a pulldown module are coupled to the input of the switch. An active pulldown module coupled to the output of the switch. The logic and sense module monitors the input to the switch and activates the active pulldown module to drain the output of the switch to a zero voltage when the input of the switch transitions to the off state.

Electrical contacts coupled to guide structures

In an example, a print component includes a guide structure. The example guide structure includes a recess to receive a print material container and a guideway with a guide wall to support rotation of the print material container. Upon rotation of the print material container, an electrical contact of the print material container moves towards an electrical contact coupled to the guide structure of the print component. In another example, a container includes a housing, a material transfer interface, and a mechanical interface. In that example, the mechanical interface includes a guide structure that defines a protrusion and a guideway to allow the container to rotate within a recess defined by a receptacle shell. Upon rotation of the container, an electrical contact coupled to the guide structure moves towards an electrical contact on the receptacle shell.

Methods of Continuously Wet Etching A Patterned Substrate

Metalized web substrate is wet etched in a reaction vessel by contacting with oxidizing and metal complexing agent to remove metal from unpatterned region. Following etching, substrate is rinsed, and rinse is at least partly recycled. Concentrations of oxidizing and metal complexing agents in the etchant bath are maintained by delivering replenishment feeds of each. Concentration of metal in the etchant bath is maintained by discharging some of the etchant bath. Replenishment rates of oxidizing and metal complexing agents and etchant removal rate are determined based at least in part on rate that metal etched from the substrate enters the etchant bath. 1. A method of patterning a substrate comprising:providing a substrate comprising a continuous web having a metalized surface having an etch resist patterned region and an unpatterned region;passing the substrate web through a reaction vessel, wherein the reaction vessel comprises an etchant bath comprising an oxidizing agent and a metal complexing agent;wet etching the substrate web within the reaction vessel by contacting the metalized surface with the oxidizing and metal complexing agents to remove metal from the unpatterned region;after wet etching the substrate: (i) rinsing the wet etched substrate with a first rinse of water; (ii)collecting the rinse; (iii) recycling at least a portion of the collected rinse to the etchant bath;maintaining the concentrations of the oxidizing and metal complexing agents in the etchant bath by delivering a replenishment feed of each of the oxidizing and metal complexing agents to the etchant bath at a first replenishment feed rate and a second replenishment feed rate, respectively; andmaintaining the concentration of the metal in the etchant bath by discharging an amount of the etchant bath from the reaction vessel at an etchant bath removal rate;wherein the first and second replenishment feed rates and the etchant bath removal rate are determined based at least in part on a rate ...

Sealed print particle transfer interface

Examples of a print particle transfer interface of a donor container are described herein. Some examples of the print particle transfer interface include a static interface portion to engage a receiving container. The static interface portion includes a static opening. Some examples of the print particle transfer interface include a rotating output assembly with a cylindrical valve seat and a seal component surrounding a valve opening. In some examples, the cylindrical valve seat rotates with respect to the static interface portion to align the valve opening for dispensing print particle to the receiving container.

Patient-specific acetabular guides and associated instruments

A patient-specific acetabular guide can be used for preparing an acetabulum of a patient to receive an acetabular implant. The acetabular guide includes a patient-specific engagement surface designed to be complementary and mateable with a corresponding surface of the patient's pelvic anatomy. The acetabular guide is designed during a pre-operative plan for the patient by a three-dimensional reconstruction of the anatomy of the patient using two-dimensional medical images. The patient-specific engagement surface has a first portion mateable with a portion of the acetabulum of the patient. The acetabular guide includes a guiding element that extends from the acetabular guide opposite to the first portion of engagement surface. The guiding element defines a bore designed to be oriented along an alignment axis for an acetabular implant when the acetabular guide is engaged to the acetabulum.

Microcontact printing stamps with functional features

A method includes providing an elastomeric stamp including a stamping surface with a first pattern element having a fill factor of 20 to 99 percent and including a continuous region and at least one discontinuous region, the discontinuous region including at least one of: (1) one or more elongated concavities, and (2) one or more interior voids. A second pattern element of the stamping surface has a fill factor of 0.25 to 10 percent, and includes traces with a width from 0.1 micrometers to 50 micrometers. The stamping surface is inked with an ink composition including a functionalizing molecule with a functional group selected to bind to a surface of the ink-receptive material. The inked stamping surface is contacted with an ink-receptive material selected from a sheet or a web for a contact time sufficient to bind the functional group with the surface of the ink-receptive material to form a self-assembled monolayer (SAM) of the functionalizing material.

Method of Making Pressure-Sensitive Adhesive Article Including Active Agent

A method includes contact printing an active composition onto a surface of a release substrate to form a printed surface. The active composition spontaneously dewets the surface of the release substrate to form active deposits on the surface of the release substrate. The active composition comprises an active agent dissolved or dispersed in an aqueous liquid vehicle. A pressure-sensitive adhesive layer is disposed on the printed surface. 1. A method of making a pressure-sensitive adhesive article , the method comprising:contact printing an active composition onto a surface of a release substrate to form a printed surface, whereby the active composition spontaneously dewets the surface of the release substrate to form active deposits on the surface of the release substrate, wherein the active composition comprises an active agent dissolved or dispersed in an aqueous liquid vehicle; anddisposing a pressure-sensitive adhesive layer on the printed surface.2. The method of claim 1 , wherein claim 1 , as initially contacted with the surface of the release substrate claim 1 , the active composition contacts a first area of the surface of the release substrate claim 1 , and wherein the active deposits contact a second area of the surface of the release substrate claim 1 , and wherein the second area is less than or equal to 50 percent of the first area.3. The method of claim 1 , wherein the active composition further comprises a hydratable polymer.4. The method of claim 1 , wherein the active agent comprises at least one non-volatile component.5. The method of claim 1 , wherein the active agent comprises at least one of an antimicrobial agent claim 1 , a topical antiseptic claim 1 , or a cationic antiseptic.6. The method of claim 1 , wherein the active agent comprises chlorhexidine gluconate.7. The method of claim 1 , wherein the active agent comprises a polymer.8. The method of claim 1 , wherein the surface of the release substrate comprises at least one of a silicone ...

Analysis of action potentials, transients, and ion flux in excitable cells

Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths. The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials, calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell.

Selecting between black print and process black print

An example method comprises identifying a plurality of supply levels corresponding to a set of print supplies of a print device. The example method further comprises coordinating depletion of the set of print supplies by selecting between black print and process black print for a print job of the print device based on the plurality of supply levels.

Method and Apparatus for Aligning and Securing an Implant Relative to a Patient

A surgical instrument for implanting a prosthetic member. The instrument includes an orientation sensor that detects an initial orientation of the prosthetic member and an implanting orientation of the prosthetic member. The instrument further includes a memory module and an input device that receives a user input to transfer the initial orientation detected by the orientation sensor into the memory module for storage. Furthermore, the instrument includes an orientation feedback device that selectively provides an orientation feedback signal to a user. Moreover, the instrument includes a controller that causes the orientation feedback device to provide the orientation feedback signal when the implanting orientation detected by the orientation sensor is substantially equal to the initial orientation stored in the memory module.

Method and Apparatus for Aligning and Securing an Implant Relative to a Patient

A surgical apparatus includes an orientation sensor that detects an actual orientation of a surgical tool. The apparatus also includes an orientation feedback device that selectively provides an orientation feedback signal. Moreover, the apparatus includes a controller that causes the orientation feedback device to provide the orientation feedback signal when the actual orientation of the surgical tool detected by the orientation sensor is substantially equal to a predetermined target orientation of the surgical tool.

Patient-specific acetabular guides and associated instruments

A patient-specific acetabular guide can be used for preparing an acetabulum of a patient to receive an acetabular implant. The acetabular guide includes a patient-specific engagement surface designed to be complementary and mateable with a corresponding surface of the patient's pelvic anatomy. The acetabular guide is designed during a pre-operative plan for the patient by a three-dimensional reconstruction of the anatomy of the patient using two-dimensional medical images. The patient-specific engagement surface has a first portion mateable with a portion of the acetabulum of the patient. The acetabular guide includes a guiding element that extends from the acetabular guide opposite to the first portion of engagement surface. The guiding element defines a bore designed to be oriented along an alignment axis for an acetabular implant when the acetabular guide is engaged to the acetabulum.

Patient-specific acetabular guides and associated instruments

A patient-specific acetabular guide can be used for preparing an acetabulum of a patient to receive an acetabular implant. The acetabular guide includes a patient-specific engagement surface designed to be complementary and mateable with a corresponding surface of the patient's pelvic anatomy. The acetabular guide is designed during a pre-operative plan for the patient by a three-dimensional reconstruction of the anatomy of the patient using two-dimensional medical images. The patient-specific engagement surface has a first portion mateable with a portion of the acetabulum of the patient. The acetabular guide includes a guiding element that extends from the acetabular guide opposite to the first portion of engagement surface. The guiding element defines a bore designed to be oriented along an alignment axis for an acetabular implant when the acetabular guide is engaged to the acetabulum.

Method and apparatus for aligning and securing an implant relative to a patient

A surgical instrument for implanting a prosthetic member. The instrument includes an orientation sensor that detects an initial orientation of the prosthetic member and an implanting orientation of the prosthetic member. The instrument further includes a memory module and an input device that receives a user input to transfer the initial orientation detected by the orientation sensor into the memory module for storage. Furthermore, the instrument includes an orientation feedback device that selectively provides an orientation feedback signal to a user. Moreover, the instrument includes a controller that causes the orientation feedback device to provide the orientation feedback signal when the implanting orientation detected by the orientation sensor is substantially equal to the initial orientation stored in the memory module.

Method and apparatus for aligning and securing an implant relative to a patient

A surgical apparatus includes an orientation sensor that detects an actual orientation of a surgical tool. The apparatus also includes an orientation feedback device that selectively provides an orientation feedback signal. Moreover, the apparatus includes a controller that causes the orientation feedback device to provide the orientation feedback signal when the actual orientation of the surgical tool detected by the orientation sensor is substantially equal to a predetermined target orientation of the surgical tool.

Method and apparatus for aligning and securing an implant relative to a patient

A surgical apparatus includes an orientation sensor that detects an actual orientation of a surgical tool. The apparatus also includes a tactile orientation feedback device that selectively provides a tactile orientation feedback signal. Moreover, the apparatus includes a controller that causes the tactile orientation feedback device to provide the tactile orientation feedback signal when the actual orientation of the surgical tool detected by the orientation sensor is substantially equal to a predetermined target orientation of the surgical tool.

Smart instrument tray RFID reader

A radio frequency identification (RFID) workstation reader for RFID-enabled surgical instruments and surgical instrument trays and a method of using a RFID workstation reader to read RFID-enabled surgical instruments and surgical instrument trays is disclosed. The method, apparatus, and system enable individual instruments or a surgical instrument tray containing several surgical instruments to be quickly and efficiently inventoried and tracked. An instrument or instrument tray is placed on the workstation reader. An RF field generated by a plurality of antennae, causes RFID tags embedded in or attached to the instrument or instrument tray to emit a signal containing item specific identification information stored in the tags. The information is received by a control circuit and passed to a computer for data analysis. A status LED is illuminated on the workstation reader based on the results of the data analysis. The method, apparatus, and system can track, inspect, and verify inbound and outbound surgical instrument kits, and help to assess the surgical instruments' and trays' duty life cycle usage.

Methods for detecting osteolytic conditions in the body

Methods and systems for detecting a biological response indicative of osteolysis or osteolytic pre-conditions in bone.

Implantable pedometer

An implantable pedometer for measuring the amount of joint use is disclosed. The implantable pedometer includes a sensor adapted for detecting indicators of joint usage. A counter is configured for storing count data corresponding to the number of indicators detected by the sensor and a telemetry circuit is configured for transmitting the count data outside of the body.

Implantable tissue growth stimulator

An implantable tissue growth stimulator is disclosed. The implantable tissue growth stimulator includes electronic circuitry to alter the voltage output by the stimulator. The implantable tissue growth stimulator may be controlled from an external device via wireless communication. The implantable tissue growth stimulator may be configured for use with an implant. In particular, the implantable tissue growth stimulator may be incorporated into an orthopaedic device such as a hip prosthesis. The implantable tissue growth stimulator may be used to stimulate bone growth.

Dynamic treatment system and method of use

A system and method are provided for monitoring the condition of the skeletal system and adjusting a treatment device to provide appropriate treatment in response to the sensed signal. More particularly, in one aspect the present invention is directed to a sensor for detecting changes at a spinal level and a dynamic treatment system adjustable in response to the detected changes.

Sensor and method for spinal monitoring

A sensor for detecting changes in spinal tissue is disclosed. The implantable sensor or surgical instrument includes a sensing element adapted for detecting indicators of tissue health. The sensor is configured for transmitting the tissue data outside of the body. Further a system and method are provided to utilize the sensed tissue properties to treat the patient's condition.

Volumetric measurement and visual feedback of tissues

Apparatus and methods for assessing tissue characteristics such as the dimensions and volume of an osteolytic lesion are disclosed. The apparatus may utilize ultrasound to provide visual and volumetric feedback related to a lesion or other tissue. Further the apparatus may be utilized to determine whether the lesion has been completely removed and filled with the appropriate amount of graft material.

Implantable sensor and associated methods

Implantable sensors and methods for detecting changes in a characteristic of a soft tissue is disclosed. In one embodiment, an implantable sensor for detecting indicators of cartilage wear in a joint is provided. The implantable sensor includes a sensing element for detecting a signal indicative of a characteristic of the cartilage of the joint and a telemetry circuit in communication with the sensing element for transmitting a data set representative of the detected signal. In another embodiment, a system for detecting changes in joint cartilage includes an implantable acoustic sensing element and an external receiver in communication with the implantable acoustic sensing element. In other embodiments, methods of detecting cartilage degradation in a joint and methods of using the disclosed sensors are provided.

Microfluidic connector

A fluid connector which provides a low fluid dead volume face seal capable of withstanding high pressures for coupling a fluid conduit to a microfluidic device. The fluid connector includes a housing, a clamping member, a first load support surface and a sealing member. The sealing member preferably includes first and second fluidically connected bores of different diameters so the fluid conduit may be retained within the larger diameter bore. The sealing member is positioned so that the smaller diameter bore interfaces with a port of the microfluidic device. In operation, the clamping member supplies an axial force to the first load support surface which is operatively coupled to the fluid conduit. When an axial force is transferred to the fluid conduit, the face of the fluid conduit at one end seals against the pliant portion of the sealing member while simultaneously urging the sealing member against the surface area surrounding the port of the microfluidic device to create a fluid-tight face seal.

Microfluidic connector

Process of preparing synthetic drying oils

Therapeutic compounds.

The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formations containing them.

Direct visualization surgical probe

A surgical probe for use in a hollow vessel or other region of the body which comprises a multi-lumen catheter having a transparent, non-compliant balloon coupled to the distal end, such that the balloon has a known shape when inflated. A direct visualization scope is provided in a first lumen of the multi-lumen catheter providing direct visualization into the hollow vessel through the non-compliant balloon. An adapter is coupled to a second lumen of the multi-lumen catheter near the proximal end to supply a transparent fluid through the second lumen to inflate the balloon to the predefined shape. In this aspect, the balloon operates to clear the scope tip by pressing tissue on the walls of the hollow vessel out of the way of the end of the scope. This provides the user of the device a consistent clear view of the tissue at the tip of the scope. A fiber optic is provided in a third lumen of the multi-lumen catheter to deliver light energy to the hollow vessel through the non-compliant balloon. A mechanism is provided for positioning the light emitting tip of the fiber optic within the balloon to establish a known propagation distance to the surface of the balloon for the light energy emitted from the light emitting tip.

Flexural rigidity profile guidewire tip

Systems and methods for automated programming of rfid tags using machine readable indicia

Methods and systems for automatically programming an RFID tag using machine readable indicia. A dual mode device performs a bar code scan of a bar coded label. Information obtained from the bar code scan is stored. This information may be used to query a database indexed by the bar code information that contains detailed product information. The bar code information as well as the detailed information may be transmitted in an RF signal by the dual mode device to an RFID tag to be stored in a memory structure in the tag. The dual mode device may perform a read operation on the tag after the write operation to confirm that the data was successfully stored and provide an indication thereof. The indication may be a visual indication, a textual indication, an audible indication or combinations of these.

Volumetric measurement and visual feedback of tissues

Apparatus and methods for assessing tissue characteristics such as the dimensions and volume of an osteolytic lesion are disclosed. The apparatus may utilize ultrasound to provide visual and volumetric feedback related to a lesion or other tissue. Further the apparatus may be utilized to determine whether the lesion has been completely removed and filled with the appropriate amount of graft material.

Method and apparatus for surgical instrument identification

Systems and methods for identifying surgical instruments by use of radio-frequency identification tags (RFID) are disclosed. In the systems and methods, each of a plurality of surgical instruments is provided with at least one RFID transponder tag storing identification information associated with the corresponding instrument. The tag may be adhered to, embedded, or potted within a portion of the instrument. Using an RFID reading device, a user may interrogate the tag, thereby identifying the particular instrument. This identification information may be used to index a database and retrieve a data record unique to that instrument. The systems and methods allow a user to track, inspect, and verify inbound and outbound surgical instruments, to assess, for example, the surgical instruments' duty life cycle usage.

Nucleic acids encoding human monoclonal antibodies to CTLA-4

In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

Rfid tag data acquisition system

An RFID system (100) that facilitates the accessing of RFID tag data within an RFID environment. The system (100) includes a plurality of RFID readers (10.1 to 10.q) and at least one controller (102). Each reader (220) includes an RF tag interrogator (236) and an RF receiver (238). Each interrogator (236) is operative to transmit an RF signal for interrogating at least one RFID tag (12) disposed within an RF coverage region associated with the interrogator (236). Each receiver (238) is operative to receive at least one RF signal including tag data in response to the interrogation of the tag. The readers (10.1 to 10.q) and the controller (102) are operative to perform RF monitoring operations to allow the controller to determine the operational status of an interrogator, and to control the operation of the interrogator and the receiver. The controller (102) is further operative to perform interrogation scheduling operations to avoid interference at at least one of a receiver and a tag. Additionally, the system (100) is operative to determine a location of at least one tag (12) with reference to a plurality of predefined locations within the environment in which the readers are deployed.

BENZIMIDAZOLES DERIVED COMPOUNDS SUBSTITUTED AS TYROSINE KINASE INHIBITORS

SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE R1 ES OH, HALO, ALQUILO(C1-C6), ALCOXI(C1-C6), ENTRE OTROS; R2 ES ALQUILO(C1-C6) O HALO(ALQUILO(C1-C6)); R3 ES HALO, ALQUILO(C1-C6) O ALCOXI(C1-C6); R4 ES OH, ALQUILO(C1-C6), HALO, CARBOXILO, ENTRE OTROS; a ES DE 1 A 5; b ES DE 0 A 3; c ES 1 O 2; R1, R2, R3 Y R4 ESTAN OPCIONALMENTE SUSTITUIDOS CON OH, HALO, ALQUILO(C1-C6), ALCOXI(C1-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: {1-METIL-5-[2-(5-TRI-FLUORO-METIL-1H-IMIDAZOL-2-IL)-PIRIDIN-4-IL-OXI]-1H-BENZO-IMIDAZOL-2-IL}-(4-TRI-FLUORO-METILFENIL)-AMINA, (2-FLUORO-5-PIRIDIN-3-IL-FENIL)-{1-METIL-5-[2-(5-TRI-FLUORO-METIL-1H-IMIDAZOL-2-IL)-PIRIDIN-4-IL-OXI]-1H-BENZO-IMIDAZOL-2-IL}-AMINA, (2-FLUORO-5-PIRIDIN-4-IL-FENIL)-{1-METIL-5-[2-(5-TRI-FLUORO-METIL-1H-IMIDAZOL-2-IL)-PIRIDIN-4-IL-OXI]-1H-BENZO-IMIDAZOL-2-IL}-AMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE SERINA/ TREONINA QUINASA O TIROSINA QUINASA DE RECEPTORES SIENDO UTILES EN EL TRATAMIENTO DE CANCER DE MAMA, CANCER DE PROSTATA, MELANOMA, CANCER PANCREATICO

Ammonia removal

A method for stripping ammonia from a film of digested sludge including flowing alkaline liquid sludge as a film on a tower's interior wall and flowing an ammonia stripping gas past the film creating a vapor containing ammonia and stripping gas; then disengaging the liquid sludge from the vapor in a tower disengaging zone.

Tension band

Various embodiments of a vertebral tension band assembly and associated connection structure are provided. The tension band assemblies may be attached to vertebral bodies to, for example, connect one vertebrae to another, retain the band in approximately a preferred position by application of tension to the band during insertion and/or limit, impede, inhibit, reduce or interfere with the separation from one vertebra to another and may further block, impede, interfere with, inhibit, reduce or present an obstacle to dislodgement of a spinal implant from between the vertebrae to which it is attached. Flexible band portions of the assemblies may be treated and/or configured to promote bony integration between the band and the associated vertebrae, limit tissue adhesion to the band, and/or to elute a therapeutic substance from the installed band to the surgical site.

Short-acting benzodiazepines

The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.

Continuous process for the production of silicon resins

Fuel pressure control valve

(57)【要約】 （修正有） 【課題】 複合光学面をソフトコンタクトレンズに形成 する方法を提供する。 【解決手段】 測定パラメーターを組み合わせ数学的な 「メタレンズ」を規定する工程と；コンタクトレンズ金 型インサートに複合光学面を規定するための機械コード データ組を自動的に作成する工程と；サブミクロン精度 と再現性がある一先端ダイヤモンド旋盤を用いて複数の コンタクトレンズ金型インサートを加工する工程と；金 型インサートを用いて複数の第一コンタクトレンズ金型 部品を同時に成形して各々に複合光学面を形成する工程 と；複数の第二のコンタクトレンズ金型部品を成形して 前記の第一のコンタクトレンズ金型部品と協働させ、一 個の第一・第二金型部品が協働して金型スペースを形成 する工程と；間に重合性モノマーを挟んで複数の第一・ 第二金型部品を組み立てる工程と；モノマーを重合して 複合光学面を形成した複数のソフトコンタクトレンズを 形成する工程を有する。

Intelligent establishment of peer-to-peer communication

A device may receive, from a first peer in a network, a request for a list of one or more candidate peers from which the first peer can obtain a resource. In addition, the device may obtain the list in response to the request, determining a set of costs based on the list, and refine the list to obtain a subset list of the candidate peers based on the set of costs. Furthermore, the device may send to, the first peer, the subset list of the candidate peers from which the first peer can obtain the resource.

Embryonic Stem Cell Derivatives, and Methods of Making and Using the Same

The presently disclosed subject matter provides embryonic stem (ES) cell derivatives that can be employed in therapeutic methods. Also provided are methods for generating and using the ES cell derivatives.

Distal protection filter and method of manufacture

Distal protection filter frame and method for using and manufacturing the same. A distal protection filter frame may include one or more struts, a mouth, and a filter coupled to the mouth.

Automated Pass-Through Surgical Instrument Tray Reader

An apparatus and method for interrogating and automatically identifying a radio-frequency tagged surgical instrument tray and its contents of RFID-tagged surgical instruments are disclosed. The surgical instrument tray and its contents come into contact with an RF signal transmitted by the RFID reader, and as a result, the RFID tags affixed on the instrument tray and the surgical instruments respond by transmitting back to the RFID reader data pertaining to the history of the surgical instruments. A data terminal, which is connected to the RFID reader, may contain data pertaining to the radio frequency tagged surgical instruments during packaging, and during the return of the surgical instrument trays to the packager, identifies the surgical instruments.

Automated pass-through surgical instrument tray reader

An apparatus and method for interrogating and automatically identifying a radio-frequency tagged surgical instrument tray and its contents of RFID-tagged surgical instruments are disclosed. The surgical instrument tray and its contents come into contact with an RF signal transmitted by the RFID reader, and as a result, the RFID tags affixed on the instrument tray and the surgical instruments respond by transmitting back to the RFID reader data pertaining to the history of the surgical instruments. A data terminal, which is connected to the RFID reader, may contain data pertaining to the radio frequency tagged surgical instruments during packaging, and during the return of the surgical instrument trays to the packager, identifies the surgical instruments.

Automated pass-through surgical instrument tray reader

An apparatus and method for interrogating and automatically identifying a radio-frequency tagged surgical instrument tray and its contents of RFID-tagged surgical instruments are disclosed. The surgical instrument tray and its contents come into contact with an RF signal transmitted by the RFID reader, and as a result, the RFID tags affixed on the instrument tray and the surgical instruments respond by transmitting back to the RFID reader data pertaining to the history of the surgical instruments. A data terminal, which is connected to the RFID reader, may contain data pertaining to the radio frequency tagged surgical instruments during packaging, and during the return of the surgical instrument trays to the packager, identifies the surgical instruments.

Systems and methods for processing surgical instrument tray shipping totes

Systems and methods for processing surgical instrument tray shipping totes. A control system is adapted to control a bar code reader module, an RFID module, a database module and an interface module. The control system provides functionality adapted to process incoming and outgoing surgical instrument shipping totes containing one or more RFID-enabled surgical instrument trays. A database, ERP system or other system in communication with the control system alerts the operator of the status of an incoming tote and/or trays contained in the tote to increase processing efficiency and speed.

Surgical instrument tray shipping tote identification system and methods of using same

A surgical instrument tray shipping tote identification system is provided. During transit to or from a medical facility, processing center, distribution center or other location, multiple surgical instruments trays are placed in an instrument tray shipping tote. Each instrument tray includes at least one RFID transponder tag storing identification information about that tray. The shipping tote has a bar coded shipping label affixed to one surface generated at the point of origin. When the tote arrives at the distribution center, it is placed on a conveyor system that includes a reading station having an RFID transceiver and a bar code reader. Information read from the RFID transponder tags and the bar code label is transmitted by a controller to an external database to check for any off-nominal status indicators. Once this check is performed, an indication is sent back to the controller and an appropriate indicator on the identification system is activated.

Workstation RFID reader for surgical instruments and surgical instrument trays and methods of using same

A radio frequency identification (RFID) workstation reader for RFID-enabled surgical instruments and surgical instrument trays and a method of using a RFID workstation reader to read RFID-enabled surgical instruments and surgical instrument trays. The method, apparatus, and system enable individual instruments or a surgical instrument tray containing several surgical instruments to be quickly and efficiently inventoried and tracked. An instrument or instrument tray is placed on the workstation reader. An RF field generated by a plurality of antennae, causes RFID tags embedded in or attached to the instrument or instrument tray to emit a signal containing item specific identification information stored in the tags. The information is received by a control circuit and passed to a computer for data analysis. A status LED is illuminated on the workstation reader based on the results of the data analysis. The method, apparatus, and system can track, inspect, and verify inbound and outbound surgical instrument kits, and help to assess the surgical instruments' and trays' duty life cycle usage.

Mixed zeolite hydrodewaxing catalysts

Abstract of the Disclosure A catalytic dewaxing process using a mixed zeolite catalyst which combines the following components: a first zeolitic catalyst having a Constraint Index not less than 1, a second, different catalytic component of specified characteristics, and a hydrogenation component.

Fast 3D cytometry for information in tissue engineering

Methods and apparatus are described for enhancing operator independent image cytometry. Aspects of the invention include enhanced tissue surface tracking which can detect both tissue surfaces. The surface detection can aid cytometry, such as by reducing the amount of image data to be stored. Segmentation is described for 3D images in which 3D least squares filtering is applied to increase contrast for simplifying the delineation of objects from backgrounds. A method of creating 3D FIR image filters based on ideal objects is also described. A data structure is defined by which 3D object data may be organized for image representations if samples. Methods of performing remote segmentation processing are also described toward centralizing the necessary processor power and applications and reducing the burden on researchers and clinicians.

REAL-TIME NON-LINEAR OPTICAL CONSTRAINING GAUGE SYSTEM

Système de mesure de contrainte comprenant une fibre optique ayant une partie centrale entre deux points fixes. Une première source de lumière émet de la lumière à une première fréquence et une seconde source de lumière, à une seconde fréquence différente. Les sources de lumière sont couplées à une première extrémité de la fibre optique. Un détecteur de rétrodiffusion est couplé à la première extrémité pour recevoir un signal lumineux de retour depuis la fibre optique et émet un signal basé dessus. Un détecteur de diffusion en avant est couplé à une seconde extrémité de la fibre optique pour recevoir un signal lumineux en avant depuis la fibre optique et émet un signal basé dessus. Un processeur reçoit les signaux du détecteur de rétrodiffusion et du détecteur de diffusion en avant et génère un signal de sortie proportionnel à la contrainte entre les deux points fixes selon les signaux reçus. A strain measurement system comprising an optical fiber having a central portion between two fixed points. A first light source emits light at a first frequency and a second light source at a second, different frequency. The light sources are coupled to a first end of the optical fiber. A backscatter detector is coupled to the first end for receiving a return light signal from the optical fiber and outputs a signal based thereon. A forward scatter detector is coupled to a second end of the optical fiber for receiving a forward light signal from the optical fiber and transmitting a signal based thereon. A processor receives signals from the backscatter detector and the forward scatter detector and generates an output signal proportional to the stress between the two fixed points according to the received signals.

Packaging adhesive having low oxygen barrier properties

A two-part laminating adhesive is provided which joins two sheets of polymeric material, which adhesive, in cured form, provides substantially no contribution to the oxygen barrier properties of the laminate. The first part is a mixture of a polyol A), preferably a polyether, and a polymer B) formed from polymerization of α,β-ethylenically unsaturated monomers, polymer B) preferably being formed in situ from monomers dissolved in polyol A). The second part is a multi-functional isocyanate, preferably an isocyanate-terminated urethane formed by reacting a poly-isocyanate monomer with a polyol.

Sales opportunity notification and tracking system and related methods

A sales notification system and related methods. Implementations include receiving a selection of a target industry identifier and a selection of a product identifier, where each product identifier is associated with a particular product and product category. The method includes generating a list of client accounts associated with the target industry identifier and product identifier where each client account is associated with a particular account segment, generating a list of potential sales representatives by retrieving all sales representatives associated with each client account, and generating a list of eligible sales representatives for each client account where each eligible sales representative is the potential sales representative who is permitted to sell the product associated with the product indicators within the product category and within the account segment associated with each client account. The method may also include using the server to generate a sales notification for each eligible sales representative.

Synchronizing data with delayed subscriptions

A technology is provided for synchronizing data with delayed subscriptions. A request may be received at a data proxy for a data snapshot for an application that has been offline at the client. A subscription may be held for a pre-determined amount of time after the request for the snapshot. The data snapshot may be sent to the client. The data for the subscription may be sent after the pre-determined amount of time.

Apparatus and method for acoustic analysis of bone using optimized functions of spectral and temporal signal components

An apparatus and method determine externally in a vertebrate subject an index of porosity and non-connectivity of a bone. A preferred embodiment has first and second transducers and a mounting arrangement for mounting the transducers in spaced relationship with respect to the bone. A signal generator, in communication with the first transducer, causes the first transducer to produce acoustic signals, having energy distributed over a frequency range, that are propagated into the subject and received by the second transducer along a path that includes the bone. Finally, the embodiment has a signal processor, in communication with the second transducer, for providing a measurement that is a function of at least one of spectral or temporal components of the signal received by the second transducer. The transducers act like a point source and point receiver.

HIGH RESOLUTION THERMOELECTRIC NANOFIL AND GRAPHIC COUPLED SENSOR SYSTEM

Un appareil électromagnétique à sélection de fréquence est proposé. L'appareil peut inclure au moins un nanofil (120) comprenant une première extrémité (122) et une seconde extrémité (124) opposée à la première extrémité (122), au moins un contact bidimensionnel (150) disposé de façon adjacente à la première extrémité (122) ou à la seconde extrémité (124) et en communication thermique, en communication électrique, ou en communication thermique ainsi qu'électrique avec l'au moins un nanofil (120), et au moins une jonction thermoélectrique de diamètre à dimension nanométrique (130) disposée entre l'au moins un contact bidimensionnel (150) et l'au moins un nanofil (120). An electromagnetic frequency selective apparatus is proposed. The apparatus may include at least one nanowire (120) having a first end (122) and a second end (124) opposite the first end (122), at least one two-dimensional contact (150) disposed adjacent to the first end (122). end (122) or at the second end (124) and in thermal communication, in electrical communication, or in thermal and electrical communication with the at least one nanowire (120), and at least one thermoelectric junction of diameter to dimension nanometer (130) disposed between the at least one two-dimensional contact (150) and the at least one nanowire (120).

System and method for measuring separation rate of water from water-in-crude oil emulsions

System and method relates to measuring separation rate of water from water-in-crude oil emulsions at elevated temperature. The system includes an electrolytic interface (conductivity) cell comprising a plurality of capacitance/conductance probes disposed at different heights in a fluid stream disposed within the interface cell and an analyzer. Logic of the analyzer determines the separation rate based on signals received from the plurality of capacitance/conductance probes in the interface cell that are coupled to monitor the fluid stream. Methods for making and using the system are also disclosed.

Layered fluid circuit assemblies and methods for making them

A layered fluid circuit (56) includes first (232) and second (234) panel sections formed from sealed sheets (230A/230B) of flexible material. A pattern of seals (S) is formed in the first panel section to define a first fluid circuit. A pattern of seals is formed in the second panel section to define a second fluid circuit. The flexible sheets are aligned to place the first and second panel sections in a relationship with the first fluid circuit overlaying the second fluid circuit. The layered fluid circuit can be placed in a tray (48) for use. Defined operating regions can be formed in one or both fluid circuits, such as in-line clamping regions (224), in-line pump tubes (155/145/201), in-line sensor regions (204), in-line fluid holding compartments (212/214), or combinations thereof.

Cone-beam computerized tomography with a flat-panel imager

Colorant compositions

Disclosed is a colorant composition of the formula wherein R is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group, and wherein R can be joined to the phenyl moiety to form a ring, R′ is an aromatic- or heteroaromatic-containing group, each R a , independently of the others, is a halogen atom, an alkyl group, an alkoxy group, a nitrile group, a nitro group, an amide group, or a sulfonamide group, w is an integer of 0, 1, 2, 3, or 4, n is an integer representing the number of carbon atoms in each repeat alkylene oxide unit, and x is an integer representing the number of repeat alkylene oxide units, wherein said colorant has no more than one —OH, —SH, or primary or secondary amino group per molecule.

Vascular stent

A medical stent includes a stent body defining a longitudinal axis and opposed longitudinal ends, and being adapted to expand from an initial condition to an expanded condition. The stent body includes a plurality of longitudinal cells. The longitudinal cells include opposed end cells and at least one intermediate cell disposed between the end cells. Each longitudinal cell has first and second structural members extending in an undulating pattern about the longitudinal axis. Intermediate connectors interconnect the first and second structural members of the at least one intermediate cell and end connectors interconnecting the first and second structural members of at least one end cell. The number of end connectors is greater than the number of intermediate connectors, and may double the number of end connectors.

Programmable delay line

A method of operating a delay circuit to impose a selected delay on an electronic signal, the delay circuit comprising a plurality of delay stages and means for directing the electronic signal through selected ones of the delay stages, the method compris? ing the steps of: measuring the actual signal delay through each of the delay stages; and selecting, based on the signal delays obtained in the measuring step, the delay stages through which the electronic signal is directed.

Hydrophilic gel materials and methods of making

The present disclosure describes articles, such as medical articles, containing a substrate having disposed thereon a hydrophilic gel material (e.g., a shaped hydrophilic gel material or a coating of a hydrophilic gel material) and methods for making such articles. Methods are provided for making hydrophilic gel materials from a precursor composition that contains a polar solvent and a polymerizable material that is miscible with the polar solvent.

Stent

A stent comprising a stent body and a plurality of cells is disclosed. The stent body defines a length. Each cell includes two structural members extending in an undulating pattern. Each structural member includes a plurality of cell segments defining a plurality of nodes therebetween. At least one node includes a non-constant radius of curvature.

Polymeric dithiocarbamic acid salt compositions and methods of use

A contaminant precipitating composition and method are disclosed. The composition comprises a water soluble branched polymeric composition effective for the purpose of precipitating contaminants from an aqueous solution . The method comprises adding an amount of the composition, effective for the purpose, to the aqueous solution so as to complex, precipitate and remove contaminants from the aqueous solution.

Aspherical toric lens

Process for filtration enhancement of aqueous dispersions

A method for enhancing filtration performance in separating solids from liquids in an aqueous dispersion comprising a solids phase and a liquid phase in a two step process having a physical separation step and a filtration step comprising adding at least one filtration aid promoter and at least one synthetic polymer to the aqueous dispersion during and/or before the physical separation step resulting in concentrate and filtering the concentrate. The method may be applied in mining operations for dewatering mining slurry. Also, a composition applied in such method comprising at least one filtration aid promoter and at least one synthetic polymer. The filtration aid promoter comprises natural polymers, semi-natural polymers, coagulants and combinations thereof.

Power factor correction circuit arrangement

L-benzimidazole nucleosides

The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.

Method of making carbon nanotubes

A method of producing a carbon nanotube product comprising a catalytic particle and single-walled carbon nanotubes deposited thereon. The catalytic particles preferably contain at least one metal from Group VIII, including for example Co, Ni, Ru, Rh, Pd, Ir, and Pt, and at least one metal from Group VIb including for example Mo, W and Cr. The catalytic particle preferably further comprises a support material such as silica. The carbon nanotube product is preferably formed by exposing the catalytic particle to a carbon-containing gas at a temperature sufficient to form the single-walled nanotubes as a primary portion of a solid carbon product on the catalytic particles.

Automatic masking system for an ODTR.

Roll-to-roll digital photolithography

A system for making flexible circuit films includes an inelastic conveyor, a web handling apparatus configured to pass a flexible substrate around the inelastic conveyor, an image acquisition apparatus configured to measure positions of a first set of alignment marks on the flexible substrate at a first conveyor location, an exposure apparatus configured to patternwise expose a photosensitive material on the flexible substrate at a second conveyor location, and an image processor configured to receive the measured positions of the first set of alignment marks, and to compare the measured positions with reference positions of the first set of alignment marks. The exposure apparatus is configured to patternwise expose the photosensitive material based on the comparison between the measured positions and the reference positions.

Instrumented implant for diagnostics

A vertebral implant (42) for interposition between first and second vertebral bodies comprises a first component (44) for engaging a vertebral endplate of the first vertebral body and a second component (46) for engaging a vertebral endplate of the second vertebral body. The second component is adapted to articulate with respect to the first component. The implant further includes a first sensor (53) for detecting a first physical parameter and a transmitter (54) coupled to the first sensor. The transmitter is adapted for interposition between the first and second vertebral bodies.

Electrical contacts coupled to guide structures

In an example, a print component includes a guide structure. The example guide structure includes a recess to receive a print material container and a guideway with a guide wall to support rotation of the print material container. Upon rotation of the print material container, an electrical contact of the print material container moves towards an electrical contact coupled to the guide structure of the print component. In another example, a container includes a housing, a material transfer interface, and a mechanical interface. In that example, the mechanical interface includes a guide structure that defines a protrusion and a guideway to allow the container to rotate within a recess defined by a receptacle shell. Upon rotation of the container, an electrical contact coupled to the guide structure moves towards an electrical contact on the receptacle shell.

Mating interface gaskets

An example of a system may include a receiving-side mating interface, including a printing substance inlet port encompassed by a receiving-side gasket material; and a dispensing-side mating interface including a printing substance dispensing nozzle, wherein the printing substance dispensing nozzle includes a dispensing-side gasket material slide-able along an internal face of the dispensing-side mating interface to seal an orifice of the printing substance dispensing nozzle within the dispensing-side mating interface and a window through the dispensing-side mating interface, wherein the dispensing-side gasket material slides against the receiving-side gasket material through the window when the outlet of the dispensing nozzle is rotated within the dispensing-side mating interface.

Field-invariant quantitative magnetic-resonance signatures

A system that determines an invariant magnetic-resonance ( MR ) signature of a biological sample is disclosed. During operation, the system determines a magnetic-resonance ( MR ) model of voxels in a biological sample based on differences between MR signals associated with the voxels in multiple scans and simulated MR signals. The MR signals are measured or captured by an MR scanner in the system during multiple MR scans, and based on scanning instructions, and the simulated MR signals for the biological sample are generated using the MR model and the scanning instructions. Moreover, the system iteratively modifies the scanning instructions (including a magnetic-field strength and/or a pulse sequence) in the MR scans based on the differences until a convergence criterion is achieved. Then, the system stores, in memory, an identifier of the biological sample and a magnetic-field-strength-invariant MR signature of the biological sample that is associated with the MR model.

Biologically-active adhesive articles and methods of manufacture

Method of designing aspherical lens

An aspheric lens for providing improved vision and a method for generating such a lens is described. The lens provides a sharp image focus while minimizing image aberrations. The method utilizes ray tracing techniques in conjunction with Modulation Transfer functions to accurately account for the total corrective lens-eye system. The lens may be in the form of a contact lens, an intraocular lens, a natural lens or a spectacle lens, and is suitable for correcting myopia, presbyopia, astigmatism and other focusing problems. The lens is characterized by a hyperbolic or parabolic surface which functions to reduce spherical aberrations and minimize the retinal image spot size.

Method and apparatus for forming chromonic nanoparticles

A method and apparatus for forming guest molecules encapsulated with chromonic material are described. The method includes atomizing a solution to form a pre-atomized particle stream. The solution includes chromonic material, a guest molecule and a carrier fluid. Then, atomizing the pre-atomized particle stream to form an atomized particle stream; evaporating at least a portion of the carrier fluid from the atomized particle stream to form a dried atomized particle stream, and forming encapsulated guest molecules from the dried atomized particle stream.

Method for selectively plugging the more permeable regions of an underground formation having non-uniform permeability

A method for selectively plugging the more permeable regions of an underground formation having non-uniform permeability wherein a first surfactant solution is injected into the formation in an amount effective to contact a substantial portion of the surface area of the highly permeable regions of the formation, which first surfactant solution is characterized as having a selected chromatographic velocity and as being capable of reversibly adsorbing onto the surface of the pores of the formation. After injecting the first surfactant solution, a water-soluble spacer fluid is injected in an amount sufficient to place the first surfactant solution a selected distant into the formation, the spacer fluid being characterized as having a pre-injection viscosity about equal to the first surfactant solution. After injecting the space fluid, a second surfactant solution is injected in an amount about equal to the amount of the first surfactant solution, and characterized as having a pre-injection viscosity about equal to the first surfactant solution and the spacer fluid, and as having a selected chromatographic velocity which is higher than the chromatographic velocity of the first surfactant solution, and has having a composition such that it will be capable of interacting physically with the first surfactant solution to produce a phase change so that the product of such interaction is capable of at least partially plugging the pores of the formation in which such product is placed.

System and method for optical analysis

An optical analysis system utilizing transmission spectroscopy for analyzing liquids and solids includes a source of optical energy, a sample, a movable optical energy transmission window, a fixed optical energy transmission window, and a detection system. The fixed transmission window remains fixed relative to the source of optical energy. The sample is selectively positioned between the movable and fixed optical energy transmission windows for analyzing the sample. The optical energy is transmitted through one of the windows, the sample, and the other window to obtain encoded optical energy as a result of transmitting the optical energy through the sample. A detection system receives the encoded optical energy for analysis. The movable optical energy transmission window is selectively movable relative to the fixed optical energy transmission window to repeatedly and precisely align and make readily accessible both windows and the sample.

Process to improve the filtration of aqueous dispersions

Concentrated liquid low calorie sweetener

MEDICAL DEVICE.

Un dispositivo médico para usarse en la administración de componente activo en o a través de la piel, que comprende: un miembro de extensión (422; 522; 622; 722) que tiene una primera superficie principal (424; 524; 624; 724) y una segunda superficie principal (426; 526; 626; 726), comprendiendo la primera superficie principal una primera parte y una segunda parte flexible; un miembro de retención de la matriz (428; 528; 628; 728) que se extiende desde la primera parte de la primera superficie principal del miembro de extensión, comprendiendo el miembro de retención de la matriz una superficie de matriz (430; 530; 630; 730) que tiene al menos una microaguja (432; 532; 632; 732) que se extiende desde la superficie de la matriz; adhesivo sensible a la presión (434; 534; 634; 734) dispuesto en la segunda parte de la primera superficie principal del miembro de extensión para facilitar la unión por el adhesivo del dispositivo a la piel de mamíferos cuando se inserta la al menos una microaguja a través de la capa córnea. y un miembro de soporte flexible (436; 536; 636; 736) que tiene una primera superficie principal (438; 538; 638; 738) y una segunda superficie principal (440; 540; 640; 740), estando fijada al menos una parte de la primera superficie principal del miembro de soporte flexible a la segunda superficie principal del miembro de extensión, extendiéndose el miembro de soporte flexible más allá del borde exterior del miembro de extensión; caracterizado porque la segunda superficie principal del miembro de extensión es relativamente lisa y sin características distintivas. A medical device for use in the administration of active component in or through the skin, comprising: an extension member (422; 522; 622; 722) having a first major surface (424; 524; 624; 724) and a second main surface (426; 526; 626; 726), the first main surface comprising a first part and a second flexible part; a matrix retention member (428; 528; 628; 728) extending from the first part of ...

Cloud-based infrastructure for determining reachability of services provided by a server

Technologies are described for using a cloud-based computer system to access services provided by a particular server over public Internet Protocol (IP) connections. In one aspect, a system includes a first computer system configured to run the particular server to provide a first service over public IP connections; and a second computer system configured to run a second server, where the particular server transmits, over public IP connections, a request for the second server to check the first service, where, responsive to receipt of the request for the second server to check the first service, the second server provides, to the particular server over public IP connections, information relating to whether the first service is available over public IP connections, and where the particular server updates an availability status of the first service over public IP connections based on the information provided by the second server.

Dispensing device for wearable drug delivery device

Embodiments of the present disclosure relate to techniques, processes, devices or systems for pump devices for providing a fixed volume of fluid, which is delivered and refilled within one pumping cycle. In one approach, a wearable drug delivery device may include a reservoir for storing a liquid drug, and a delivery pump device including a drive mechanism coupled to the reservoir. The drive mechanism may include a housing having a pump chamber fluidly connected with a channel chamber, an inlet channel operable to deliver the liquid drug from the reservoir to the channel chamber, and an outlet channel operable to expel the liquid drug from the channel chamber. The drive mechanism may further include a resilient sealing member sealing the pump chamber, and a plunger adjacent the resilient sealing member, wherein the plunger is operable to enter the pump chamber to displace the liquid drug from the pump chamber.

Apparatus and method for acoustic analysis of bone using optimized functions of spectral and temporal signal components

An apparatus and method determine externally in a vertebrate subject an inde x of porosity and non-connectivity of a bone. A preferred embodiment has first and second transducers and a mounting arrangement for mounting the transduce rs in spaced relationship with respect to the bone. A signal generator, in communication with the first transducer, causes the first transducer to produce acoustic signals, having energy distributed over a frequency range, that are propagated into the subject and received by the second transducer along a path that includes the bone. Finally, the embodiment has a signal processor, in communication with the second transducer, for providing a measurement that is a function of at least one of spectral or temporal components of the signal received by the second transducer. The transducers act like a point source and point receiver.

Method of producing lenses

An aspheric lens for providing improved vision and a method for generating such a lens is described. The lens provides a sharp image focus while minimizing image aberrations. The method utilizes ray tracing techniques in conjunction with Modulation Transfer functions to accurately account for the total corrective lens-eye system. The lens may be in the form of a contact lens, an intraocular lens, a natural lens or a spectacle lens, and is suitable for correcting myopia, presbyopia, astigmatism and other focusing problems. The lens is characterized by a hyperbolic or parabolic surface which functions to reduce spherical aberrations and minimize the retinal image spot size.