HIGH PERFORMANCE LDMOS DEVICE HAVING ENHANCED DIELECTRIC STRAIN LAYER

An LDMOS device includes a substrate having a surface and a gate electrode overlying the surface and defining a channel region in the substrate below the gate electrode. A drain region is spaced apart from the channel region by an isolation region. The isolation region includes a region of high tensile stress and is configured to induce localized stress in the substrate in close proximity to the drain region. The region of high tensile stress in the isolation region can be formed by high-stress silicon oxide or high-stress silicon nitride. In a preferred embodiment, the isolation region is a shallow trench isolation region formed in the substrate intermediate to the gate electrode and the drain region. 1. An LDMOS device comprising:a substrate having a surface;a gate electrode overlying the surface and a channel region in the substrate below the gate electrode;an isolation region; anda drain region in the substrate and spaced apart from the gate electrode at the surface by the isolation region, the isolation region comprising a region of high tensile stress,wherein the isolation region is configured to apply localized stress in the substrate in close proximity to the drain region.2. The device of claim 1 , wherein the isolation region comprises a shallow trench isolation region.3. The device of claim 2 , wherein the shallow trench isolation region comprises a high-stress silicon nitride region separated from the shallow trench by a silicon oxide liner.4. The device of claim 2 , wherein the shallow trench isolation region comprises a plasma deposited silicon oxide within the shallow trench.5. The device of claim 1 , wherein the isolation region is configured to apply localized tensile stress.6. The device of claim 1 , wherein the isolation region is spaced apart from the channel region by a distance sufficient to substantially avoid applying stress to the channel region.714.-. (canceled)15. An LDMOS device comprising a high tensile stress isolation region in ...

High Efficiency Ejector Cycle

A system () has a compressor (), a heat rejection heat exchanger (), first () and second () ejectors, first () and second () heat absorption heat exchangers, and a separator. The ejectors each have a primary inlet () coupled to the heat rejection exchanger to receive refrigerant. A second heat absorption heat exchanger () is coupled to the outlet of the second ejector to receive refrigerant. The separator () has an inlet () coupled to the outlet of the first ejector to receive refrigerant from the first ejector. The separator has a gas outlet () coupled to the secondary inlet () of the second ejector to deliver refrigerant to the second ejector. The separator has a liquid outlet () coupled to the secondary inlet () of the first ejector via the first heat absorption heat exchanger to deliver refrigerant to the first ejector. 1200250270. A system (; ; ) comprising:{'b': '22', 'a compressor ();'}{'b': '30', 'a heat rejection heat exchanger () coupled to the compressor to receive refrigerant compressed by the compressor;'}{'b': '38', 'claim-text': [{'b': '40', 'a primary inlet () coupled to the heat rejection heat exchanger to receive refrigerant;'}, {'b': '42', 'a secondary inlet (); and'}, {'b': '44', 'an outlet ();'}], 'a first ejector () having{'b': '64', 'a first heat absorption heat exchanger ();'}{'b': '202', 'claim-text': [{'b': '204', 'a primary inlet () coupled to the heat rejection heat exchanger to receive refrigerant;'}, {'b': '206', 'a secondary inlet (); and'}, {'b': '208', 'an outlet ();'}], 'a second ejector () having{'b': '220', 'a second heat absorption heat exchanger () coupled to the outlet of the second ejector to receive refrigerant; and'}{'b': '48', 'claim-text': [{'b': '50', 'an inlet () coupled to the outlet of the first ejector to receive refrigerant from the first ejector;'}, {'b': '54', 'a gas outlet () coupled to the secondary inlet of the second ejector to deliver refrigerant to the second ejector; and'}, {'b': '52', 'a liquid outlet () ...

PEGYLATED LIPOSOMES FOR DELIVERY OF IMMUNOGEN ENCODING RNA

Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass of between 1 kDa and 3 kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is between 1 kDa and 3 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases. 1. A liposome within which RNA encoding an immunogen of interest is encapsulated , wherein the liposome comprises at least one lipid which includes a polyethylene glycol moiety , such that polyethylene glycol is present on the liposome's exterior , wherein the average molecular mass of the polyethylene glycol is between 1 kDa and 3 kDa.2. The liposome of claim 1 , comprising PEG-DMG and/or a lipid of formula (X).3. The liposome of claim 1 , wherein the liposome has a diameter in the range of 80-160 nm.4. The liposome of claim 1 , wherein the liposome comprises a lipid with a cationic head group.5. The liposome of claim 1 , wherein the liposome comprises a lipid with a zwitterionic head group.6. The liposome of claim 1 , wherein the RNA is a self-replicating RNA.7. The liposome of claim 6 , wherein the self-replicating RNA encodes (i) a RNA-dependent RNA polymerase which can transcribe RNA from the self-replicating RNA molecule and (ii) an immunogen.8. The liposome of claim 7 , wherein the self-replicating RNA has two open reading frames claim 7 , the first of which encodes an alphavirus replicase and the second of which encodes the immunogen.9. The ...

DEPTH FROM MOTION FOR AUGMENTED REALITY FOR HANDHELD USER DEVICES

A handheld user device includes a monocular camera to capture a feed of images of a local scene and a processor to select, from the feed, a keyframe and perform, for a first image from the feed, stereo matching using the first image, the keyframe, and a relative pose based on a pose associated with the first image and a pose associated with the keyframe to generate a sparse disparity map representing disparities between the first image and the keyframe. The processor further is to determine a dense depth map from the disparity map using a bilateral solver algorithm, and process a viewfinder image generated from a second image of the feed with occlusion rendering based on the depth map to incorporate one or more virtual objects into the viewfinder image to generate an AR viewfinder image. Further, the processor is to provide the AR viewfinder image for display. 1. A method for providing an augmented reality (AR) experience at a handheld user device , the method comprising:capturing, via a monocular camera of the handheld user device, a feed of images of a local scene;selecting, from the feed, a keyframe;performing, for a first image from the feed of images, stereo matching using the first image, the keyframe, and a relative pose based on a pose associated with the first image and a pose associated with the keyframe to generate a sparse disparity map representing disparities between the first image and the keyframe;determining a dense depth map from the disparity map using a bilateral solver algorithm;processing a viewfinder image generated from a second image of the feed with occlusion rendering based on the depth map to incorporate one or more virtual objects into the viewfinder image to generate an AR viewfinder image; anddisplaying, at the handheld user device, the AR viewfinder image.2. The method of claim 1 , further comprising:polar rectifying the keyframe and the first image; andwherein performing stereo matching comprising performing stereo matching using ...

SENSORY FEEDBACK INDICATORS FOR TRANSACTIONAL PROCESSES

A method for providing web transaction feedback includes a client device receiving a response indicating a success or a failure of a user operation pertaining to a potential web transaction. The client device then provides a web transaction feedback to the user using a human interface element capable of causing the client device to perform a set of motions and/or emit a range of temperatures. The set of motions is comprised of at least a first sub-set of the set of motions indicating the success of the user operation and at least a second sub-set of the set of motions indicating the failure of the user operation. The range of temperatures is comprised of at least a first temperature of the range of temperatures indicating the success of the user operation and at least a second temperature of the range of temperatures indicating the failure of the user operation. 1receiving, by a client device, a first response indicating a success or a failure of a first user operation pertaining to a potential web transaction, wherein the first user operation includes the user attempting to submit sensitive information using a web form on a website, and wherein the received first response indicates whether the website is a secure website or an unsecure website;providing, by the client device, first web transaction feedback to the user, where the first web transaction feedback communicates the received first response to the user using a first human interface element capable of causing the client device to emit a range of temperatures;receiving, by a client device, a second response indicating a success or a failure of a second user operation pertaining to the potential web transaction, wherein the second user operation includes the user submitting payment information for the potential web transaction, and wherein the received second response indicates whether the payment information submitted by the user has been successfully approved or unsuccessfully approved; andproviding, by the ...

MANAGING PARALLEL PROCESSES FOR APPLICATION-LEVEL PARTITIONS

Various techniques are described herein for creating data partition process schedules and executing such partition schedules using multiple parallel process instances. Data processing tasks initiated by or for applications may be executed by creating and executing partition schedules, in which a number of different process instances are created and each assigned a subset of data to process. Partition schedules may be used to determine a number of process instances to be created, and each process instance may be assigned a unique set of run-time data values corresponding to a unique set of parameters within the data set to be processed by the application. The process instances may operate independently and in parallel to retrieve and process separate partitions of the data required for the overall data processing task initiated by/for the application. 1. A process scheduling and management system comprising:a processing unit comprising one or more processors; and identify a plurality of parameters within a data set comprising one or more data tables stored in a backend data store;', 'for each parameter of the identified parameters, determine a number of unique values for the parameter within the data set;', 'determine a number of process instances to create of a data processing executable component, said determining comprising multiplying the number of unique values for each of the identified parameters;', 'create the determined number of process instances of the data processing executable component; and', 'provide to each of the process instances data corresponding to a unique combination of values of the identified parameters within the data set, wherein the unique combinations of values for the process instances are determined independently of the backend data store storing the data tables, and wherein each of the process instances is configured to retrieve a unique set of target data from the data tables, based on the unique combination of values provided to the ...

PROCESS SCHEDULING AND EXECUTION IN DISTRIBUTED COMPUTING ENVIRONMENTS

Embodiments of the invention provide systems and methods for scheduling and executing user-restricted processes within distributed computing systems. More specifically, certain embodiments of the present invention describe systems and methods by which runtime requests to execute user-restricted processes may be received, processed, and scheduled via a user application of an enterprise system or other distributed computing system. Requests may be received via transaction pages of user applications to schedule and execute user-restricted processes. The user application, a process scheduler, and/or other components within the distributed computing system may determine user contexts associated with the requests, and may determine whether or not the requested processes may be scheduled and executed. Such processes may include, for example, report generation processes, processes to initiate system functions, and/or processes to perform system maintenance within the distributed computing environment. 1. A method for scheduling execution of a user-restricted process within a distributed computing system , the method comprising:receiving a runtime request to execute a user-restricted process within a distributed computing system, the runtime request received via a transaction page of a user application during a runtime session of a user within the distributed computing system;determining a current user context associated with the runtime request, the current user context based on at least one of the transaction page, the user, and the runtime session of the user within the distributed computing system;determining whether or not to permit execution of the user-restricted process based on the current user context associated with the runtime request; andscheduling execution of the user-restricted process based on a determination to permit execution of the user-restricted process.2. The method of claim 1 , wherein scheduling execution of the user-restricted process comprises: ...

Systems and Methods for Animation Generation

Systems and methods for animating from audio in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating animation from audio. The method includes steps for receiving input audio data, generating an embedding for the input audio data, and generating several predictions for several tasks from the generated embedding. The several predictions includes at least one of blendshape weights, event detection, and/or voice activity detection. The method includes steps for generating a final prediction from the several predictions, where the final prediction includes a set of blendshape weights, and generating an output based on the generated final prediction. 1. A method for generating animation from audio , the method comprising:receiving input audio data;generating an embedding for the input audio data;generating a plurality of predictions for a plurality of tasks from the generated embedding, wherein the plurality of predictions comprises at least one of blendshape weights, event detection, and voice activity detection;generating a final prediction from the plurality of predictions, wherein the final prediction comprises a set of blendshape weights; andgenerating an output based on the generated final prediction.2. The method of claim 1 , wherein the input audio data comprises mel-frequency cepstral coefficient (MFCC) features.3. The method of claim 2 , wherein generating the embedding comprises utilizing at least one of a recurrent neural network and a convolutional neural network to generate the embedding based on the MFCC features.4. The method of claim 1 , wherein generating the plurality of predictions comprises utilizing a multi-branch decoder claim 1 , wherein the multi-branch decoder comprises a plurality of Long Short Term Memory networks (LSTMs) that generate predictions for the plurality of tasks based on the generated embedding.5. The method of claim 1 , wherein generating the plurality of predictions ...

Data compression

Methods and system are disclosed that compress a dataset and optimize the dataset for searching data. In one aspect, based on attributes associated with a unified dataset, the dataset including sensor node identifier data, sensor node timestamp data and sensor measurement data are determined. A suffix tree algorithm may be executed to determine data compression logic to compress the dataset including the sensor node identifier data and sensor node measurement data. A sensor node timestamp data compression model may be executed to compress the dataset associated with the sensor timestamp data. The compressed datasets including the sensor node identifier data, the sensor node timestamp data and the sensor measurement data may be stored in an in-memory data store.

METHOD AND SYSTEM FOR OBTAINING PAIR-WISE EPIPOLAR CONSTRAINTS AND SOLVING FOR PANORAMA POSE ON A MOBILE DEVICE

Aspects of the disclosure generally relate to connecting panoramic images. One or more computing devices may load and display a first panoramic image captured at a first location and receive a selection of an area on the first panoramic image, the area corresponding to where a connection to other panoramic images may be made. The one or more computing devices may identify and display one or more nearby panoramic images which were captured near the first location and receive a selection of one of the one or more nearby panoramic images. The one or more computing devices may display the selected panoramic image and the first panoramic image and align the selected panoramic image with the first panoramic image such that the selected panoramic image is oriented in the same direction as the first panoramic image. The one or more computing devices may connect the selected panoramic image with the first panoramic image. 115-. (canceled)16. A computer implemented method for connecting panoramic images , the method comprising:loading and displaying, with one or more computing devices, a first panoramic image captured at a first location;receiving, by the one or more computing devices, a selection of an area on the first panoramic image, the area corresponding to where a connection to other panoramic images may be made;identifying and displaying, by the one or more computing devices, one or more nearby panoramic images which were captured near the first location;receiving, by the one or more computing devices, a selection of one of the one or more nearby panoramic images;displaying, by the one or more computing devices, the selected panoramic image and the first panoramic image;aligning, by the one or more computing devices, the selected panoramic image with the first panoramic image such that the selected panoramic image is oriented in the same direction as the first panoramic image; andconnecting, by the one or more computing devices, the selected panoramic image with the ...

LIPOSOMES HAVING USEFUL N:P RATIO FOR DELIVERY OF RNA MOLECULES

Nucleic acid immunisation is achieved by delivering a RNA encapsulated within a liposome comprising a cationic lipid, wherein the liposome and the RNA have a N:P ratio of between 1:1 and 20:1. 1. A liposome in which an immunogen-encoding RNA is encapsulated , wherein the liposome comprises a cationic lipid and the liposome and RNA have a N:P ratio of between 1:1 and 20:1.2. The liposome of claim 1 , having a diameter in the range of 50-220 nm.3. The liposome of or claim 1 , wherein the RNA is a self-replicating RNA4. The liposome of claim 3 , wherein the self-replicating RNA encodes (i) a RNA-dependent RNA polymerase which can transcribe RNA from the self-replicating RNA molecule and (ii) an immunogen.5. The liposome of claim 4 , wherein the self-replicating RNA has two open reading frames claim 4 , the first of which encodes an alphavirus replicase and the second of which encodes the immunogen.6. The liposome of claim 1 , wherein the RNA is 9000-12000 nucleotides long.7. The liposome of claim 1 , wherein the immunogen can elicit an immune response in vivo against a bacterium claim 1 , a virus claim 1 , a fungus or a parasite.8. The liposome of claim 7 , wherein the immunogen can elicit an immune response in vivo against respiratory syncytial virus glycoprotein F.9. The liposome of claim 1 , wherein the liposome and RNA have a N:P ratio between 2:1 and 18:1.10. The liposome of claim 1 , wherein the liposome and RNA have a N:P ratio between 3:1 and 11:1.11. The liposome of claim 1 , wherein the liposome and RNA have a N:P ratio between 4:1 and 16:1.12. The liposome of claim 1 , wherein the liposome and RNA have a N:P ratio between 6:1 and 14:1.13. The liposome of claim 1 , wherein the liposome and RNA have a N:P ratio between 8:1 and 12:1.14. The liposome of claim 1 , wherein the liposome and RNA have a N:P ratio of 2:1 claim 1 , 4:1 claim 1 , 8:1 or 10:1.15. A pharmaceutical composition comprising a liposome of .16. A method for raising a protective immune response ...

Automated Reversing By Following User-Selected Trajectories and Estimating Vehicle Motion

A method for autonomously driving a vehicle in a rearward direction towards a point of interest is provided. The method includes receiving one or more images from a camera positioned on a back portion of the vehicle and receiving a driver planned path from a user interface. The driver planned path includes a plurality of waypoints. The method also includes transmitting one or more commands to a drive system causing the vehicle to autonomously maneuver along the driver planned path. The method also includes determining a current vehicle position and an estimated subsequent vehicle position. The method also includes determining a path adjustment from the current vehicle position to the estimated subsequent vehicle position. The method also includes transmitting instructions to the drive system causing the vehicle to autonomously maneuver towards the estimated subsequent vehicle position based on the path adjustment.

Methods and apparatuses for document processing at distributed processing nodes

Briefly, the disclosure describes embodiments of methods or apparatuses for document processing at distributed processing nodes.

SYSTEMS AND METHODS FOR MANAGING CUSTOMER ENGAGEMENTS

A system for managing customer engagements of a client is provided. The system includes an event tracker configured to track at least one of transactional data and customer profile data of a plurality of customers of the client and a customizable rule engine configured to dynamically generate one or more customized rules using parameters associated with at least one of the transactional data and the customer profile data. The system also includes a customer event management module coupled to the event tracker and to the customizable rule engine, wherein the customer event management module is configured to analyze the transactional data and the d customer profile data for each customer to select one or more applicable rules and to apply the selected rules to generate one or more customized offers for the respective customer. The system further includes a customer engagement module configured to execute instructions for transmitting the one or more customized offers to the respective customer. 1. A system for managing customer engagements of a client , comprising:an event tracker configured to track at least one of transactional data and customer profile data of a plurality of customers of the client;a customizable rule engine configured to dynamically generate one or more customized rules using parameters associated with at least one of the transactional data and the customer profile data;a customer event management module coupled to the event tracker and to the customizable rule engine, wherein the customer event management module is configured to analyze the transactional data and the customer profile data for each customer to select one or more applicable rules and to apply the selected rules to generate one or more customized offers for the respective customer; anda customer engagement module configured to execute instructions for transmitting the one or more customized offers to the respective customer.2. The system of claim 1 , wherein the transactional data ...

METHOD, PROCESS AND APPARATUS FOR THE VERY LOW TEMPERATURE EVAPORATION SYSTEM

The method, process and apparatus for very low temperature evaporation system novelty of the invention lies in the concept of method, process and apparatus for evaporation and concentration at very low temperature ranges from 5° C. to 80° C. to recover water vapour from liquids or solutions or industrial effluents or spentwash or industrial wastewater or juices or syrups or slurry or sludge or brine or sewer or wastewater or any other evaporative liquid materials in single or multiple effect heat exchanger arranged in horizontal or vertical manner with mechanical vapour compression system under vacuum. This very low temperature evaporation system operates at lowest temperature for maximum clean water recovery from liquids or solutions or industrial effluents or industrial wastewater. The apparatus for low temperature evaporation system eliminates or reduces the utilization of heat generation and rejection units along with other benefits like reduces water extraction from earth and energy losses.

COLD JUICE CLARIFICATION PROCESS

A process for cold clarification of juice is described. A sugar cane or beet juice clarification process to clarify raw juice by means of aeration of fresh raw juice, addition of milk or lime, anionic and/or cationic flocculants, particularly together with a carbonating process, addition of phosphoric acid and then passing the juice through activated carbon bed is described. The process eliminates the need to heat the juice at any stage thus making it more cost effective, energy saving and gives better yield in terms of quality and quantity both. The recycling of defecated, carbonated and phosphated filtered juice and carbonated and phosphated mud that reduces the consumption of lime, COand phosphoric acid up to some extent is described. 1. A cold juice clarification process used for sugar cane or beet juice in order to remove colour , turbidity and other impurities , wherein the same comprises steps of:(i) de-aeration of raw juice under vacuum;(ii) addition of milk of lime in de-aerated juice for pH adjustment;(iii) addition of flocculants in de-aerated juice;(iv) setting and separation of defecated mud from defecated juice;(v) addition of milk of lime in defecated juice for pH adjustment;(vi) bubbling of CO2 in defecated juice from step (v);(vii) addition of flocculants in carbonated juice from step (vi);(viii) settling and separation of carbonated mud from carbonated juice;(ix) addition of phosphoric acid in carbonated juice from step (viii);(x) addition of flocculants in carbonated juice of step (ix);(xi) settling and separation of phosphated mud from phosphated juice;(xii) passing phosphated juice through activated carbon bed; and(xiii) filtration of juice.2. The cold juice clarification process in claimed in claim 1 , wherein defecated muddy juice is passed through filter press and recycled to de-aerated juice chamber.3. The cold juice clarification process as claimed in claim 1 , wherein the filtered carbonated juice is recycled to the carbonation process ...

Tensioning Control Device

A tensioning control device having a first motor that applies a torque to a first end of a substrate in a first direction and a second motor that applies a torque to a second end of the substrate in a second direction that is generally opposite the first direction is disclosed. In this manner, the first motor and the second motor apply torque to the substrate in opposing directions, thereby placing the substrate in tension. In one embodiment, the first motor applies a torque to the first end of the substrate that is equal to the torque applied to the second end of the substrate by the second motor. By placing the substrate in tension in this manner, an actuator is able to incrementally move the substrate in a forward direction and a backward direction independent of the tension applied to the substrate 1. A tensioning control device for tensioning a substrate , comprising:a first motor applying a first torque to a first end of the substrate in a first direction; anda second motor applying a second torque to an opposing second end of the substrate in a second direction, the second direction generally opposite the first direction thereby placing the substrate in tension.2. The tensioning control device of claim 1 , wherein the first torque applied to the first end of the substrate is equal to the second torque applied to the opposing second end of the substrate.3. The tensioning control device of claim 1 , further comprising an actuator adapted to move the substrate in a forward direction and a backward direction.4. The tensioning control device of claim 3 , wherein the actuator is adapted to move the substrate in the forward direction and the backward direction independent of the tension applied to the substrate.5. The tensioning control device of claim 3 , wherein the actuator is adapted to move the substrate by predetermined increments.6. The tensioning control device of claim 1 , further comprising a printing configured to print onto a portion of the substrate.7. ...

Syringe Labeling Device

A labeling device for a syringe that includes a first labeling subsystem adapted to print a first label having machine readable information and a second labeling subsystem adapted to print a second label having human readable information is disclosed. The first labeling subsystem includes a label applicator adapted to automatically apply the first label to a portion of the syringe. The first labeling subsystem includes a syringe clamp assembly that securely holds the syringe while the label applicator automatically applies a first label to the syringe. The second labeling subsystem includes a removal device adapted to automatically remove a backing material from the second label. 1. A labeling device for a syringe , comprising:a first labeling subsystem adapted to print a first label comprising machine readable information; anda second labeling subsystem adapted to print a second label comprising human readable information.2. The labeling device of claim 1 , wherein the first labeling subsystem includes a label applicator adapted to automatically apply the first label to a portion of the syringe.3. The labeling device of claim 2 , wherein the label applicator automatically applies the first label to a luer tip of the syringe.4. The labeling device of claim 1 , wherein the machine readable information is a barcode indicating a content or quality of the syringe.5. The labeling device of claim 1 , wherein the machine readable information and the human readable information each indicate a content or quality of the syringe.6. The labeling device of claim 1 , further comprising a housing claim 1 , wherein the first labeling subsystem and the second labeling subsystem are each provided within the housing.7. A labeling device for a syringe claim 1 , comprising: a clamp assembly adapted to hold the syringe;', 'a first printer adapted to print a first label comprising machine readable information; and', 'a label applicator assembly adapted to automatically apply the first ...

SYSTEM AND METHOD OF DOCUMENTING CLINICAL TRIALS

Disclosed is a system for documenting clinical trials, the system when operated identifies at least one publication related to a clinical trial entry to obtain documented clinical trial. The system comprises: an information repository comprising plurality of publications; a clinical trials registry database comprising a plurality of clinical trial entries; and a server arrangement. The server arrangement is configured to: obtain the plurality of publications; analyze the plurality of publications, using a filtering module, to determine a filtered set of publications; obtain the plurality of clinical trial entries; analyze a context of each of the publications in the filtered set and each of the plurality of clinical trial entries using a mapping module to identify a relationship of each of the publication with at least one of the plurality of clinical trial entries; and associate the plurality of clinical trial entries with publications related thereto to obtain documented clinical trials. 1. A system for documenting clinical trials , the system when operated identifies at least one publication related to a clinical trial entry to obtain a documented clinical trial , wherein the system comprises:an information repository comprising a plurality of publications;a clinical trials registry database comprising a plurality of clinical trial entries; and obtain the plurality of publications from the information repository;', 'analyze the plurality of publications, using a filtering module, to determine a filtered set of publications, wherein each of the publications in the filtered set is related to clinical trial research;', 'obtain the plurality of clinical trial entries from the clinical trials registry database;', 'analyze a context of each of the publications in the filtered set and each of the plurality of clinical trial entries using a mapping module to identify a relationship of each of the publication with at least one of the plurality of clinical trial entries; ...

PEGYLATED LIPOSOMES FOR DELIVERY OF IMMUNOGEN-ENCODING RNA

Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass above 3 kDa but less than 11 kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is above 3 kDa but less than 11 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases, 1. 11. (canceled)12. A method for raising a protective immune response in a vertebrate , comprising the step of administering to the vertebrate an effective amount of the a liposome wherein the liposome comprises at least one lipid which includes a polyethylene glycol moiety , such that polyethylene glycol is present on the liposome's exterior , wherein the average molecular mass of the polyethylene glycol is above 3 kDa but less than 11 kDa.13. A method for raising a protective immune response in a vertebrate , comprising the step of administering to the vertebrate an effective amount of a pharmaceutical composition comprising a liposome , wherein the liposome comprises at least one lipid which includes a polyethylene glycol moiety , such that polyethylene glycol is present on the liposome's exterior , wherein the average molecular mass of the polyethylene glycol is above 3 kDa but less than 11 kDa.14. The method of claim 12 , comprising PEG-DMG and/or a lipid of formula.15. The method of claim 12 , wherein the liposome comprises a lipid with a cationic head group.16. The method of claim 12 , wherein the liposome comprises a lipid ...

LIPOSOMES HAVING USEFUL N:P RATIO FOR DELIVERY OF RNA MOLECULES

Nucleic acid immunisation is achieved by delivering a RNA encapsulated within a liposome comprising a cationic lipid, wherein the liposome and the RNA have a N:P ratio of between 1:1 and 20:1. 115.-. (canceled)16. A method for raising a protective immune response in a vertebrate , comprising the step of administering to the vertebrate an effective amount of a liposome comprising a cationic lipid and the liposome and RNA have a N:P ratio of between 1:1 and 20:1.17. A method for raising a protective immune response in a vertebrate , comprising the step of administering to the vertebrate an effective amount of a pharmaceutical composition comprising a liposome wherein the liposome comprises a cationic lipid and the liposome and RNA have a N:P ratio of between 1:1 and 20:1.18. The method of claim 16 , wherein the vertebrate is a human or a veterinary mammal.19. The method of claim 16 , wherein the RNA is self-replicating.20. The method of claim 19 , wherein the self-replicating RNA encodes (i) a RNA-dependent RNA polymerase which can transcribe RNA from the self-replicating RNA molecule and (ii) an immunogen.21. The method of claim 19 , wherein the self-replicating RNA has two open reading frames claim 19 , the first of which encodes an alphavirus replicase and the second of which encodes the immunogen.22. The method of claim 19 , wherein the immunogen can elicit an immune response in vivo against respiratory syncytial virus glycoprotein F.23. The method of claim 16 , wherein the immunogen may elicit an immune response against a bacterium claim 16 , virus claim 16 , fungus claim 16 , or parasite.24. The method of claim 16 , wherein the immune response may comprise an antibody response.25. The method of claim 16 , wherein the immune response may comprise a cell-mediated immune response. This application is a continuing application of U.S. patent application Ser. No. 14/130,748, filed on Jan. 3, 2014, which is a national stage entry of PCT/US2012/045829, filed Jul. 6, ...

3D POSITION ESTIMATION SYSTEM FOR TRAILER COUPLER

A system for locating a coupler of a trailer includes at least one camera positioned on a rear portion of a tow vehicle. A coupler detector module is constructed and arranged 1) to receive images of the coupler from the at least one camera and 2) to determining a two-dimensional (2D) pixel position of the coupler. A camera motion estimator module is constructed and arranged 1) to receive images from the at least one camera and data regarding motion of the tow vehicle and 2) determine a pose of the camera including a three-dimensional (3D) position and heading of the at least one camera. A coupler estimator module is constructed and arranged 1) to receive the pose of the camera and the 2D pixel position of the coupler and based thereon, 2) to determine an estimated 3D position of the coupler in real world coordinates. 1. A method of locating a coupler of a trailer , the method comprising:receiving, at a coupler detector module, images of the coupler from a camera positioned on a rear portion of a tow vehicle and in communication with the coupler detector module;determining, in the coupler detector module, a two-dimensional (2D) pixel position of the coupler;receiving, by a camera motion estimator module, images from the camera in communication with the camera motion estimator module, and data regarding motion of the tow vehicle;determining, by the camera motion estimator module, a pose of the camera including a three-dimensional (3D) position and heading of the camera;receiving, by a coupler estimator module, the pose of the camera and the 2D pixel position of the coupler; andbased on the pose of the camera and the 2D pixel position of the coupler, determining, by the coupler estimator module, an estimated 3D position of the coupler in real world coordinates.2. The method of claim 1 , wherein the estimated 3D position of the coupler in real world coordinates includes a longitude position claim 1 , a latitude position claim 1 , and a height position of the coupler.3. ...

ROBUST FACIAL ANIMATION FROM VIDEO USING NEURAL NETWORKS

Implementations described herein relate to methods, systems, and computer-readable media to generate animations for a 3D avatar from input video captured at a client device. A camera may capture video of a face while a trained face detection model and a trained regression model output a set of FACS weights, head poses, and facial landmarks to be translated into the animations of the 3D avatar. Additionally, a higher level-of-detail may be intelligently selected based upon user preferences and/or computing conditions at the client device. 1. A computer-implemented method , comprising:identifying, using a fully convolutional network, a set of bounding box candidates from a first frame of a video, wherein each bounding box candidate includes a face;refining, using a convolutional neural network, the set of bounding box candidates into a bounding box;obtaining a first set of one or more of a predefined facial expression weight, a head pose, and facial landmarks based on the bounding box and the first frame using an overloaded output convolutional neural network;generating a first animation frame of an animation of a three-dimensional (3D) avatar based on the first set of the one or more of the predefined facial expression weight, the head pose, and the facial landmarks, wherein a head pose of the avatar matches the head pose in the first set and facial landmarks of the avatar match the facial landmarks in the first set; and detecting whether the bounding box, applied to the additional frame, includes the face;', 'if it is detected that the bounding box includes the face, obtaining an additional set of the one or more predefined facial expression weights, head poses, and facial landmarks based on the bounding box and the additional frame, using the overloaded output convolutional neural network; and', 'generating an additional animation frame of the animation of the 3D avatar using the additional set., 'for each additional frame of the video subsequent to the first frame ...

Induced Stem Memory T-Cells and Methods of Use Thereof

Methods and compositions for inducing CD8+ T cells to express a CD62LCD44naïve-like phenotype are provided. One embodiment provides a pharmaceutical composition containing CD8+ T cells induced to express a CD62LCD44naïve-like phenotype and optionally an excipient. The CD8+ T cells can be induced by contacting them with an effective amount of a MEK1/2 inhibitor. An exemplary MEK1/2 inhibitor is Selumetinib. The induced CD8+ cells can be used to treat cancer, reduce tumor burden, or treat infections in a subject in need thereof. 1. A pharmaceutical composition comprising:{'sup': +', 'hi', 'lo, 'a population of CD8 T-cells induced to express CD62LCD44naïve-like phenotype and optionally an excipient.'}2. The composition of claim 1 , wherein the CD8 T-cells are induced to express CD62LCD44naïve-like phenotype by contacting the CD8+ T cells with an effective amount of an inhibitor of MEK1/2.3. The composition of claim 2 , wherein the MEK1/2 inhibitor comprises Selumetinib.4. The pharmaceutical composition of claim 1 , comprising 10to 10induced CD8+ T cells.5. A method for inducing a stem cell memory T cells (T) like phenotype in CD8 T-cells comprising{'sup': +', '+, 'sub': 'SCM', 'contacting the CD8 T-cells in vitro with an effective amount of an inhibitor of MEK1/2 to induce a Tphenotype in the CD8 T-cells; and optionally'}{'sup': '+', 'expanding the induced CD8 T-cells in culture.'}6. The method of claim 5 , wherein the induced CD8 T-cells comprise CD62LCD44naïve-like CD8 T-cells having elevated levels of Sca1 compared to untreated naïve cells.7. The method of claim 5 , wherein the MEK1/2 inhibitor comprises Selumetinib.8. A method for treating an infection or cancer comprising administering the pharmaceutical composition of to a subject in need thereof in combination or alternation with an immunostimulatory agent claim 1 , a potentiating agent claim 1 , or a combination thereof.9. The method of claim 8 , wherein the potentiating agent comprises cyclophosphamide.10. The ...

Service-based security per user location in mobile networks

Techniques for providing service-based security per user location in mobile networks (e.g., service provider networks for mobile subscribers) are disclosed. In some embodiments, a system/process/computer program product for service-based security per user location in mobile networks in accordance with some embodiments includes monitoring network traffic on a service provider network at a security platform to identify a new session, wherein the service provider network includes a 5G network or a converged 5G network; extracting user location information for user traffic associated with the new session at the security platform; and determining a security policy to apply at the security platform to the new session based on the user location information.

Tensioning Control Device

A tensioning control device having a first motor that applies a torque to a first end of a substrate in a first direction and a second motor that applies a torque to a second end of the substrate in a second direction that is generally opposite the first direction is disclosed. In this manner, the first motor and the second motor apply torque to the substrate in opposing directions, thereby placing the substrate in tension. In one embodiment, the first motor applies a torque to the first end of the substrate that is equal to the torque applied to the second end of the substrate by the second motor. By placing the substrate in tension in this manner, an actuator is able to incrementally move the substrate in a forward direction and a backward direction independent of the tension applied to the substrate. 1. A labeling system for labeling a syringe , the labeling system comprising:a material having a label and configured to be applied to the syringe, the material having a first end and an opposing second end;a first motor applying a first torque to the first end of the material in a first direction; anda second motor applying a second torque to the opposing second end of the material in a second direction, the second direction generally opposite the first direction thereby placing the material in tension.2. The labeling system of claim 1 , further comprising an actuator adapted to move the material in a forward direction and a backward direction independent of the tension applied to the material.3. The labeling system of claim 1 , further comprising a cutting mechanism for cutting a portion of the label.4. The labeling system of claim 1 , wherein the material comprises a removable backing layer.5. The labeling system of claim 4 , further comprising a removal device adapted to automatically remove the removable backing layer from the material.6. The labeling system of claim 1 , wherein the first torque applied to the first end of the material is equal to the second ...

Retail optimization for markdown

Methods and system are disclosed that support optimization for markdown in retail domain to generate an optimized price for a product. The markdown optimization is mapped to a genetic algorithm. In one aspect, an initial population of candidate solutions initializes the execution of the genetic algorithm. Based on a fitness function associated with an objective, the genetic algorithm iteratively executes on the initial population of candidate solutions to compute a fitness score corresponding to each candidate solution. In another aspect, based on the fitness score, the candidate solutions are selected to breed or generate candidate solutions for next-generation. The genetic algorithm terminates when a termination condition is met and may generate a set of particularly desirable result set. In yet another aspect, particularly desirable result set is validated by applying constraints and the validated particularly desirable result set represents most desirable result set.

PROCESS SCHEDULING AND EXECUTION IN DISTRIBUTED COMPUTING ENVIRONMENTS

Embodiments of the invention provide systems and methods for scheduling and executing user-restricted processes within distributed computing systems. More specifically, certain embodiments of the present invention describe systems and methods by which runtime requests to execute user-restricted processes may be received, processed, and scheduled via a user application of an enterprise system or other distributed computing system. Requests may be received via transaction pages of user applications to schedule and execute user-restricted processes. The user application, a process scheduler, and/or other components within the distributed computing system may determine user contexts associated with the requests, and may determine whether or not the requested processes may be scheduled and executed. Such processes may include, for example, report generation processes, processes to initiate system functions, and/or processes to perform system maintenance within the distributed computing environment. 1. A method for scheduling execution of a user-restricted process within a distributed computing system , the method comprising:receiving a runtime request to execute a user-restricted process within a distributed computing system, the runtime request received via a transaction page of a user application during a current runtime session of a user within the distributed computing system;determining one or more characteristics of the current runtime session of the user within the distributed computing system;determining whether or not to permit execution of the user-restricted process based on (i) the user-restricted process, (ii) the user, and (iii) the determined characteristics of the current runtime session of the user within the distributed computing system; andin response to determining that the execution of the user-restricted process is permitted, scheduling execution of the user-restricted process.2. The method of claim 1 , wherein the one or more characteristics of the ...

PEGYLATED LIPOSOMES FOR DELIVERY OF IMMUNOGEN-ENCODING RNA

The invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is above 3 kDa but less than 11 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.

Apparatus and Method to Join a Coupler and Flow Tube in an Ultrasonic Flow Meter

A flow sensor sub-assembly for sensing flow of a fluidic medicament includes a flow tube having an inlet and an outlet, a first coupler secured to the inlet of the flow tube, a second coupler secured to the outlet of the flow tube, a first piezo element secured to the first coupler, a second piezo element secured to the second coupler to define a predetermined distance between the first piezo element and the second piezo element, and at least one absorber sleeve engaged with the first coupler, the flow tube, and the second coupler. 1. A flow sensor sub-assembly for sensing flow of a fluidic medicament comprising:a flow tube having an inlet and an outlet;a first coupler secured to the inlet of the flow tube;a second coupler secured to the outlet of the flow tube;a first piezo element secured to the first coupler;a second piezo element secured to the second coupler to define a predetermined distance between the first piezo element and the second piezo element; andat least one absorber sleeve engaged with the first coupler, the flow tube, and the second coupler.2. The flow sensor sub-assembly of claim 1 , wherein the at least one absorber sleeve comprises a first absorber sleeve engaged with the first coupler and the flow tube and a second absorber sleeve engaged with the second coupler and the flow tube claim 1 , the first absorber sleeve spaced from the second absorber sleeve to define a gap.3. The flow sensor sub-assembly of claim 2 , wherein the flow tube is not covered by any absorbing material in the gap between the first absorber sleeve and the second absorber sleeve.4. The flow sensor sub-assembly of claim 2 , wherein the first absorber sleeve and the second absorber sleeve each cover at least 10% of a length of the flow tube between the first and second couplers.5. The flow sensor sub-assembly of claim 4 , wherein the first absorber sleeve and the second absorber sleeve each cover 25% of the length of the flow tube between the first and second couplers.6. The ...

DEVICE FOR ORAL DELIVERY OF ACTIVE AGENTS

A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5. 1. A device for the delivery of an agent to an intestinal site , the device comprising a backing element , a mucoadhesive element for adhering the device to the intestinal site , and a reservoir comprising the agent , whereinthe mucoadhesive element comprises a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.2. A device for the delivery of an agent to an intestinal site , the device comprising a backing element , a mucoadhesive element for adhering the device to the intestinal site , a push element for induction of convective flow of the agent to the intestinal site , and a reservoir comprising the agent , whereinthe agent comprises molecules having a molecular weight of at least 100 Da, the push element comprises an osmagent, the mucoadhesive element comprises a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of ...

Flow Sensor System

A system may include a disposable flow sensor and a base for the disposable flow sensor. A method may include scanning, with an optical scanner of the base for the disposable flow sensor, a flow sensor label attached to the disposable flow sensor to decode a flow sensor identifier associated with the flow sensor, scanning, with the optical scanner of the base for the disposable flow sensor, a patient label attached to a patient to decode a patient identifier associated with the patient, and connecting the disposable flow sensor to the base. 1. A method comprising:scanning, with an optical scanner of a base for a disposable flow sensor, a flow sensor label attached to the disposable flow sensor to decode a flow sensor identifier associated with the flow sensor;scanning, with the optical scanner of the base for the disposable flow sensor, a patient label attached to a patient to decode a patient identifier associated with the patient; andconnecting the disposable flow sensor to the base.2. The method of claim 1 , further comprising:integrating the disposable flow sensor into an IV line.3. The method of claim 2 , wherein the disposable flow sensor is integrated into the IV line before scanning the flow sensor label claim 2 , scanning the patient label claim 2 , and connecting the disposable flow sensor to the base.4. The method of claim 2 , wherein the disposable flow sensor is integrated into the IV line after scanning the flow sensor label claim 2 , scanning the patient label claim 2 , and connecting the disposable flow sensor to the base.5. The method of claim 1 , further comprising:communicating, with the base, the flow sensor identifier and the patient identifier to a remote computing device; andassociating, with the remote computing device in a database, the flow sensor identifier with the patient identifier.6. The method of claim 1 , further comprising:communicating, with the base, to a remote computing device, a request for a status of the flow sensor ...

Flow Sensor System

A system may include a flow sensor and a base. The flow sensor may include a flow tube, a sensor configured to characterize at least one attribute of a fluid in the flow tube, and an electrical contact in electrical communication with the sensor. The flow tube may include a fluid inlet at a first end of the flow tube, a fluid outlet at a second end of the flow tube, a fluid injection port between the first and second ends of the flow tube, and a valve configured to control a flow of a fluid in the flow tube. The base may include a processor, an electrical contact in electrical communication with the processor, a short range wireless communication device, and a display. The flow sensor electrical contact may be in electrical communication with the base electrical contact when the flow sensor is connected to the base. 1. A system comprising: a flow tube including a fluid inlet at a first end of the flow tube, a fluid outlet at a second end of the flow tube opposite the first end of the flow tube, a fluid injection port between the first end and the second end of the flow tube, and a valve configured to control a flow of a fluid in the flow tube;', 'at least one sensor configured to characterize at least one attribute of the fluid in the flow tube; and', 'a flow sensor electrical contact in electrical communication with the at least one sensor; and, 'a flow sensor including one or more processors;', 'a base electrical contact in electrical communication with the one or more processors;', 'a short range wireless communication device; and', 'a display,, 'a base configured to connect to the flow sensor, wherein the base includeswherein the flow sensor electrical contact is in electrical communication with the base electrical contact when the flow sensor is connected to the base.2. The system of claim 1 , wherein the valve is configured transition between a plurality of different states to control at least one of: the flow of the fluid between the fluid inlet and the fluid ...

Data meta-model based feature vector set generation for training machine learning models

This disclosure relates generally to data meta model and meta file generation for feature engineering and training of machine learning models thereof. Conventional methods do not facilitate appropriate relevant data identification for feature engineering and also do not implement standardization for use of solution across domains. Embodiments of the present disclosure provide systems and methods wherein datasets from various sources/domains are utilized for meta file generation that is based on mapping of the dataset with a data meta model based on the domains, the meta file comprises meta data and information pertaining to action(s) being performed. Further functions are generated using the meta file and the functions are assigned to corresponding data characterized in the meta file. Further functions are invoked to generate feature vector set and machine learning model(s) are trained using the features vector set. Implementation of the generated data meta-model enables re-using of feature engineering code.

Method and Apparatus for Wetting Internal Fluid Path Surfaces of a Fluid Port to Increase Ultrasonic Signal Transmission

A method for readying a fluid sensor associated with a medical device includes attaching a flow restrictor to a fluid outlet of the fluid sensor. The fluid sensor includes a fluid channel, a fluid inlet at a first end of the fluid channel configured to couple to an outlet of an administrable fluid source, and the fluid outlet at a second end of the fluid channel. Fluid is delivered from the administrable fluid source to the fluid channel through the fluid inlet. A syringe actuation device including a force limiting device may be used to deliver the fluid. The fluid is pressurized in the fluid channel between the fluid inlet and the flow restrictor to wet an interior surface of the fluid channel with the fluid. The flow restrictor is removed from the fluid outlet. 1. An apparatus for controlling a plunger of a syringe to deliver a fluid from an interior of the syringe , comprising:an actuator rod extending from a proximal end to a distal end;a plunger engagement portion engaged with the distal end of the actuator rod and configured to engage the plunger of the syringe; anda body having a proximal end, a distal end, and an opening at the proximal end, wherein the opening receives the plunger engagement portion, and wherein the plunger engagement portion is threadably engaged with the body.2. The apparatus of claim 1 , wherein the plunger engagement portion is configured to inhibit an application of a force to the plunger of the syringe that violates a threshold force.3. The apparatus of claim 1 , wherein the plunger engagement portion inhibits movement of the plunger of the syringe in response to a plunger reaction force applied by the plunger of the syringe.4. The apparatus of claim 1 , further comprising a clutch that engages the distal end of the actuator rod to the plunger engagement portion.5. The apparatus of claim 4 , further comprising a spring that extends within the actuator rod.6. The apparatus of claim 5 , wherein the spring extends within the actuator rod ...

Use of Female Mammal's Urine for Determination of Fetal Gender Related Characteristics

The present invention provides a method for determining the gender of a fetus by assaying the sex hormones, evaluating the overall reducing/oxidizing (redox) activity, and/or evaluating the radical scavenging capacity of the maternal urine or other body fluid. The method can be used to determine fetal gender at any time point during the entire pregnancy. The body fluid may be processed before assaying. Processing may involve aging the body fluid, or purification of various fractions. The methods of the present invention also provide for a means for pre-conception offspring gender planning by assaying the sex hormones, evaluating the overall reducing/oxidizing (redox) activity, and/or evaluating the radical scavenging capacity of the urine or other body fluid from a non-pregnant female. The sex hormone profiles, the overall redox activity, and/or the radical scavenging capacity of a urine sample correlates with the gender specific compatibility of the ovum being released during a particular menstrual cycle. Therefore, assaying aforementioned parameters from a non-pregnant female's urine will help a couple or an animal breeder have an offspring of a desired gender. The present invention also provides a method of conceiving a baby of a desired gender in a female by applying to the female a pharmaceutical formulation with a specific sex hormone composition.

Cmp composition for polishing hard materials

A slurry for chemical mechanical polishing (CMP) includes an aqueous liquid carrier, an oxygen and anion containing transition metal compound or polyatomic cations including a transition metal and oxygen or hydrogen, and a per-based oxidizer. The anion for the oxygen and anion containing transition metal compound can include oxynitrate, oxychloride, oxyhydroxide, oxyacetate, oxysulfide, or oxysulfate. The per-based oxidizer can be a permanganate compound.

Method and Apparatus for Wetting Internal Fluid Path Surfaces of a Fluid Port to Increase Ultrasonic Signal Transmission

A method for readying a fluid sensor associated with a medical device includes attaching a flow restrictor to a fluid outlet of the fluid sensor. The fluid sensor includes a fluid channel, a fluid inlet at a first end of the fluid channel configured to couple to an outlet of an administrable fluid source, and the fluid outlet at a second end of the fluid channel. Fluid is delivered from the administrable fluid source to the fluid channel through the fluid inlet. A syringe actuation device including a force limiting device may be used to deliver the fluid. The fluid is pressurized in the fluid channel between the fluid inlet and the flow restrictor to wet an interior surface of the fluid channel with the fluid. The flow restrictor is removed from the fluid outlet. 1. A system comprising: a fluid channel,', 'a fluid inlet at a first end of the fluid channel configured to couple to an outlet of an administrable fluid source, and', 'a fluid outlet at a second end of the fluid channel; and, 'a fluid sensor includinga flow restrictor configured to be attached to the fluid outlet of the fluid sensor.2. The system of claim 1 , wherein the flow restrictor comprises an outlet having an inner diameter that changes in response to a varying pressure applied to a fluid in the fluid channel claim 1 , thereby creating a perturbative flow of the fluid in the fluid channel.3. The system of claim 2 , wherein the flow restrictor comprises an elastomeric material.4. The system of claim 1 , wherein the flow restrictor includes an outlet of approximately 34 G.5. The system of claim 1 , wherein the administrable fluid source includes a syringe including a plunger claim 1 , and wherein the system further comprises:a syringe actuation device configured to apply a force to the plunger of the syringe, which results in a pressure being applied to a fluid in the fluid channel.6. The system of claim 5 , further comprising:a pressure sensor configured to determine a current pressure of the fluid ...

PEGYLATED LIPOSOMES FOR DELIVERY OF IMMUNOGEN-ENCODING RNA

Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass of between 1 kDa and 3 kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is between 1 kDa and 3 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases. 1. A method for raising a protective immune response in a vertebrate , comprising the step of administering to the vertebrate an effective amount of a liposome within which RNA encoding an immunogen of interest is encapsulated , wherein the liposome comprises at least one lipid which includes a polyethylene glycol moiety , such that polyethylene glycol is present on the liposome's exterior , wherein the average molecular mass of the polyethylene glycol is between 1 kDa and 3 kDa.2. The method of further comprising PEG-DMG and/or a lipid of formula (X).4. The method of claim 1 , wherein the liposome has a diameter in the range of 80-160 nm.5. The method of claim 1 , wherein the liposome comprises a lipid with a cationic head group.6. The method of claim 1 , wherein the liposome comprises a lipid with a zwitterionic head group.7. The method of claim 1 , wherein the RNA is a self-replicating RNA.8. The method of claim 7 , wherein the self-replicating RNA molecule encodes (i) a RNA-dependent RNA polymerase which can transcribe RNA from the self-replicating RNA molecule and (ii) an immunogen.9. The method of claim 8 , wherein the RNA molecule has two open ...

Variable virtual split dictionary for search optimization

Methods and system are disclosed that optimize attribute vectors to search for data. In one aspect, a reordering optimization model is executed to reorder the attribute vectors. The attribute vectors may include value identifiers associated with data. The attribute vectors are assigned priorities, sequence score corresponding to each attribute vector is computed and the attribute vectors are reordered based on the computed sequence score. The reordered attribute vectors are logically partitioned into attribute vector blocks by executing a partitioning optimization model. The attribute vector blocks may be generated upon executing the partitioning optimization model. The value identifiers in the attribute vector blocks may be rearranged to optimize the attribute vectors to search for data.

Methods and Compositions for the Intravenous Administration of Fumarates for the Treatment of Neurological Diseases

Disclosed herein are methods and compositions for the intravenous administration of fumarates for the treatment of neurological diseases, such as stroke, amyotrophic lateral sclerosis, Huntington's disease, Alzheimer's disease, Parkinson's disease, and Multiple Sclerosis.

Composition for immediate and extended release

The subject invention relates to fast dissolving pharmaceutical compositions comprising an active ingredient for immediate release and further comprising a controlled release dosage form comprising an active ingredient for controlled release.

Ultra-dense ferroelectric memory with self-aligned patterning

Described is an ultra-dense ferroelectric memory. The memory is fabricated using a patterning method by that applies atomic layer deposition with selective dry and/or wet etch to increase memory density at a given via opening. A ferroelectric capacitor in one example comprises: a first structure (e.g., first electrode) comprising metal; a second structure (e.g., a second electrode) comprising metal; and a third structure comprising ferroelectric material, wherein the third structure is between and adjacent to the first and second structures, wherein a portion of the third structure is interdigitated with the first and second structures to increase surface area of the third structure. The increased surface area allows for higher memory density.

Capacitors with ferroelectric/antiferroelectric and dielectric materials

Disclosed herein are capacitors with ferroelectric or antiferroelectric (FE/AFE) material and dielectric material, as well as related methods and devices. In some embodiments, a capacitor may include two electrodes, a layer of FE/AFE material between the electrodes, and a layer of dielectric material between the electrodes.

Self-Locking Fluid Coupling Assembly

In one exemplary embodiment of the present disclosure a fluid coupling assembly defining an axial direction, a radial direction, and a circumferential direction is provided. The fluid coupling assembly includes a male coupling including a first MC attachment interface, a second MC attachment interface, and an outer surface extending along the circumferential direction; a ferrule coupling including an FC attachment interface pressed against the first MC attachment interface, a lip extending along the radial direction, and an outer surface extending along the circumferential direction to define a circular shape; and a nut coupling including an NC attachment interface rotatably engaged with the second MC attachment interface, a flange extending along the radial direction and pressed against the lip of the ferrule coupling, and an inner surface extending along the circumferential direction to define a circular shape; wherein the outer surface of the male coupling, the outer surface of the ferrule, or the inner surface of the nut coupling includes a plurality of non-resilient protrusions spaced along the circumferential direction for contacting an opposing

SYSTEM AND METHOD TO IDENTIFY ENTITY OF DATA

Disclosed is system comprising data processing arrangement including processors configured to receive sentences from unlabeled training data set; tokenize, using tokenizer module, sentences to obtain tokens; generate character level features for character of tokens of sentences; generate token level feature for each token of the sentences, wherein token level feature of token in sentence is identified using token coordinates of token and token coordinates of tokens neighboring token in sentence; train artificial neural network adapted to identify entities in sentences to determine first trend set, wherein training is based on received sentences, character level features for each character of tokens of sentences and token level feature for tokens of sentences; train the artificial neural network on set of labelled data to determine second trend set; identify, using identifier module, entity in text content, wherein identifier module uses first trend set and second trend set determined by artificial neural network. 1. A system comprising: receive one or more sentences from unlabeled training data set;', 'tokenize, using a tokenizer module, the one or more sentences to obtain a plurality of tokens;', 'generate a character level features for each character of the plurality of tokens of the one or more sentences, wherein the character level features of each of the character is identified based on demographics of each of the tokens;', 'generate a token level feature for each token of the plurality of tokens of the one or more sentences, wherein the token level feature of a given token in a given sentence is identified using token coordinates of the given token and token coordinates of tokens neighboring the given token in the given sentence;', 'train an artificial neural network adapted to identify one or more entities in sentences to determine a first trend set, wherein the training is based on the received one or more sentences, the character level features for each ...

Medical diagnostic and treatment systems and their methods of use

Embodiments related to methods and wearable medical detecting systems for detecting disease states and/or treatment states of a subject are described. In one embodiment, a wearable structure may include one or more radiation detectors use to detect a time varying radiation signal emitted from a labeled compound within a body portion of interest. The radiation signal may be analyzed to determine one or more signal characteristics that may be compared to one or more predetermined standard characteristics associated with known disease and/or treatment states to determine a current disease and/or treatment state of a subject.

SENSORY FEEDBACK INDICATORS FOR TRANSACTIONAL PROCESSES

A method for providing web transaction feedback includes a client device receiving a response indicating a success or a failure of a user operation pertaining to a potential web transaction. The client device then provides a web transaction feedback to the user using a human interface element capable of causing the client device to perform a set of motions and/or emit a range of temperatures. The set of motions is comprised of at least a first sub-set of the set of motions indicating the success of the user operation and at least a second sub-set of the set of motions indicating the failure of the user operation. The range of temperatures is comprised of at least a first temperature of the range of temperatures indicating the success of the user operation and at least a second temperature of the range of temperatures indicating the failure of the user operation. 1 program instructions to receive, by a client device, a first response indicating a success or a failure of a first user operation pertaining to a potential web transaction, wherein the first user operation includes the user attempting to submit sensitive information using a web form on a website, and wherein the received first response indicates whether the website is a secure website or an unsecure website;', 'program instructions to determine, by the client device, first web transaction feedback, wherein the first web transaction feedback communicates the received first response to the user;', 'program instructions to provide, by the client device, the first web transaction feedback to the user using a thermal emitter capable of causing the client device to emit a range of temperatures;', 'program instructions to receive, by the client device, a second response indicating a success or a failure of a second user operation pertaining to the potential web transaction, wherein the second user operation includes the user submitting payment information for the potential web transaction, and wherein the ...

SENSORY FEEDBACK INDICATORS FOR TRANSACTIONAL PROCESSES

A method for providing web transaction feedback includes a client device receiving a response indicating a success or a failure of a user operation pertaining to a potential web transaction. The client device then provides a web transaction feedback to the user using a human interface element capable of causing the client device to perform a set of motions and/or emit a range of temperatures. The set of motions is comprised of at least a first sub-set of the set of motions indicating the success of the user operation and at least a second sub-set of the set of motions indicating the failure of the user operation. The range of temperatures is comprised of at least a first temperature of the range of temperatures indicating the success of the user operation and at least a second temperature of the range of temperatures indicating the failure of the user operation. 1one or more computer processors;one or more computer readable storage media; program instructions to receive, by a client device, a first response indicating a success or a failure of a first user operation pertaining to a potential web transaction, wherein the first user operation includes the user attempting to submit sensitive information using a web form on a website, and wherein the received first response indicates whether the website is a secure website or an unsecure website;', 'program instructions to determine, by the client device, first web transaction feedback, wherein the first web transaction feedback communicates the received first response to the user;', 'program instructions to provide, by the client device, the first web transaction feedback to the user using a thermal emitter capable of causing the client device to emit a range of temperatures;', 'program instructions to receive, by the client device, a second response indicating a success or a failure of a second user operation pertaining to the potential web transaction, wherein the second user operation includes the user submitting ...

METHODS FOR DETECTING AND REVERSING IMMUNE THERAPY RESISTANCE

Compositions and methods of their use to detect and treat anti-PD1 therapy resistance are provided herein. Compositions that immunospecifically bind and deplete dysfunctional T cells are provided. The dysfunctional T cells that are depleted include CD38PD-1 T cells, CD38CD8 T-cells, or both. The dysfunctional T cells can be depleted, for example, by administering an antibody or fusion protein that specifically binds to dysfunctional T cells and promotes their depletion. In one embodiment the antibody is a bispecific antibody that can be specific for CD38 and CD8, or it can be specific for CD38 and PD-1. Also disclosed is a method of detecting and treating anti-PD1 therapy resistance by measuring the amount of CD38+PD1+CD8 T cells in blood or tissue samples obtained from a subject prior to anti-PD1 therapy and administering an anti-CD38/CD8 or anti-CD38/PD-1 depleting/blocking antibody to the subject prior to anti-PD1 therapy. 2. The method of claim 1 , wherein the composition comprising an effective amount of a compound that promotes or enhances the depletion of CD38CD8 T cells claim 1 , CD38PD-1 T cells claim 1 , or both claim 1 , or decreases the activity of CD38 on T cells in the subject is anti-CD38 antibody.3. The method of claim 1 , wherein the composition comprising an effective amount of a compound that promotes or enhances the depletion of CD38CD8 T cells claim 1 , CD38PD-1 T cells claim 1 , or both claim 1 , or decreases the activity of CD38 on T cells in the subject is a bispecific anti-CD38/anti-CD8 antibody.4. The method of claim 1 , wherein the composition comprising an effective amount of a compound that promotes or enhances the depletion of CD38CD8 T cells claim 1 , CD38PD-1 T cells claim 1 , or both claim 1 , or decreases the activity of CD38 on T cells in the subject is a bispecific anti-CD38/anti-PD-1 antibody.5. The method of claim 1 , wherein the composition comprising an effective amount of a compound that promotes or enhances the depletion of ...

Visual Object Tracker

A method for tracking a trailer coupler positioned behind a tow vehicle is provided. The method includes receiving one or more images from a camera positioned on a back portion of the tow vehicle. The method also includes determining a trailer coupler position within the one or more images. The trailer coupler position associated with the trailer coupler. Additionally, the method includes receiving vehicle sensor data from one or more vehicle sensors. The method includes determining vehicle motion data based on the received vehicle sensor data. The method also includes determining an updated coupler position based on the trailer coupler position and the vehicle motion data.

Syringe Labeling Device

A labeling device for a syringe that includes a first labeling subsystem adapted to print a first label having machine readable information and a second labeling subsystem adapted to print a second label having human readable information is disclosed. The first labeling subsystem includes a label applicator adapted to automatically apply the first label to a portion of the syringe. The first labeling subsystem includes a syringe clamp assembly that securely holds the syringe while the label applicator automatically applies a first label to the syringe. The second labeling subsystem includes a removal device adapted to automatically remove a backing material from the second label. 1. A labeling subsystem for a labeling device for a syringe , comprising:a clamp assembly adapted to hold the syringe;a printer adapted to print a first label comprising machine readable information; anda label applicator assembly adapted to automatically apply the first label to a portion of the syringe.2. The labeling subsystem of claim 1 , wherein the clamp assembly includes a groove adapted to receive the syringe.3. The labeling subsystem of claim 2 , wherein the clamp assembly includes an arm moveable between an open position claim 2 , in which the arm does not contact the syringe claim 2 , and a closed position claim 2 , in which the arm contacts the syringe and the syringe is held between the arm and the groove.4. The labeling subsystem of claim 3 , wherein the clamp assembly includes a roller rotatably connected to the arm.5. The labeling subsystem of claim 3 , wherein the arm is movably connected to a base portion via a pin connection at the base portion.6. The labeling subsystem of claim 1 , wherein the clamp assembly includes a roller rotatably connected to an arm moveable between an open position claim 1 , in which the roller does not contact the syringe claim 1 , and a closed position claim 1 , in which the roller contacts the syringe.7. The labeling subsystem of claim 6 , ...

Security for cellular internet of things in mobile networks

Techniques for providing security for Cellular Internet of Things (CIoT) in mobile networks (e.g., service provider networks for mobile subscribers) are disclosed. In some embodiments, a system/process/computer program product for enhanced security for CIoT in mobile networks in accordance with some embodiments includes monitoring network traffic on a service provider network at a security platform to identify a subscriber identity for a new session, in which the session is associated with a CIoT device; determining an application identifier for user traffic associated with the new session at the security platform; and determining a security policy to apply at the security platform to the new session based on the subscriber identity and the application identifier.

SYSTEMS AND METHODS FOR IMPLEMENTING IMPROVED LINKS BETWEEN PATHS OF ONE OR MORE FILE SYSTEMS

Representative embodiments set forth herein disclose techniques for implementing improved links between paths of one or more file systems. According to some embodiments, techniques are disclosed for establishing a system volume and a data volume within a container. According to other embodiments, techniques are disclosed for establishing a link from a source path of a system volume within a container to a target path of a data volume within the container. According to yet other embodiments, techniques are disclosed for determining whether to allow a file system operation on a data volume of a container based on at least determining whether a target path is associated with a reference to a source path. 1. A method for establishing a system volume and a data volume within a container , the method comprising:receiving a request to establish the system volume and the data volume within the container;determining that the system volume and the data volume are associated with a specific volume group, wherein the specific volume group defines an exclusive relationship between the system volume and the data volume within the container;assigning a data role to the data volume and a system role to the system volume based on the exclusive relationship defined by the specific volume group; andestablishing the system volume having the system role and the data volume having the data role within the container.2. The method of claim 1 , further comprising:receiving a second request to establish a second system volume and a second data volume within the container;determining that the second system volume and the second data volume are associated with a second specific volume group, wherein the second specific volume group defines a second exclusive relationship between the second system volume and the second data volume within the container;assigning a second data role to the second data volume and a second system role to the second system volume based on the second exclusive ...

DEVICE FOR ORAL DELIVERY OF ACTIVE AGENTS

A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5. 157.-. (canceled)58. A device for the delivery of an agent to an intestinal site , the device comprising a backing element , a mucoadhesive layer for adhering the device to the intestinal site , and a reservoir comprising the agent , whereinthe mucoadhesive layer comprises a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) formed through the mucoadhesive layer and extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, the mucoadhesive layer having a thickness of about 50 nm to about 10 mm, i. each of the passageway(s) has a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5; or', 'the agent comprises molecules having a molecular weight of at least 100 Da, the push element comprises an osmagent, and said passageways are permeable to said molecules; or', 'ii. the device comprises a push element for induction of convective flow of the agent to the intestinal site, wherein'}, {'sub': 'avg', 'claim-text': {'sub': avg', 'avg, 'wherein the population has a number average minimum diameter, Davg, of at least 10 microns, ...

Extracellular vesicle-aso constructs targeting stat6

The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), wherein the ASO comprises a contiguous nucleotide sequence of 10 to 30 nucleotides in length that is complementary to a nucleic acid sequence within a STAT6 transcript. Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.

Extracellular vesicle-nlrp3 antagonist

The present disclosure relates to extracellular vesicles, e.g. , exosomes, comprising an NLRP3 antagonist. In some aspects, the NLRP3 antagonist comprises an antisense oligonucleotide (ASO). Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.

Extracellular vesicle-aso constructs targeting cebp/beta

The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), wherein the ASO comprises a contiguous nucleotide sequence of 10 to 30 nucleotides in length that is complementary to a nucleic acid sequence within a CEBP/ transcript. Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.

1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

Extracellular vesicle-ASO constructs targeting CEBP/beta

The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), wherein the ASO comprises a contiguous nucleotide sequence of 10 to 30 nucleotides in length that is complementary to a nucleic acid sequence within a CEBP/ transcript. Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.

Extracellular vesicle-nlrp3 antagonist

The present disclosure relates to extracellular vesicles, <i>e.g.</i>, exosomes, comprising an NLRP3 antagonist. In some aspects, the NLRP3 antagonist comprises an antisense oligonucleotide (ASO). Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.

Extracellular vesicle-aso constructs targeting stat6

The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), wherein the ASO comprises a contiguous nucleotide sequence of 10 to 30 nucleotides in length that is complementary to a nucleic acid sequence within a STAT6 transcript. Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.

Method for controlling an eye surgical laser, treatment apparatus, computer program as well as computer-readable medium

The invention relates to a method for controlling an eye surgical laser ( 18 ) for removing a volume body ( 12 ) from a cornea ( 44 ) with an anterior interface ( 16 ) of the cornea ( 44 ) and a posterior interface ( 14 ) of the cornea ( 44 ), comprising the steps of: presetting the posterior actual interface ( 14 ); determining a first imaging point ( 48 ) of the cornea ( 44 ); determining an anterior target interface ( 46 ) depending on the posterior actual interface ( 14 ) and the first imaging point ( 48 ) based on a mathematical model (M); determining a shape of the volume body ( 12 ) to be generated by presetting the determined anterior target interface ( 46 ); and generating control data for generating the volume body ( 12 ) such that the anterior actual interface ( 16 ) corresponds to the determined anterior target interface ( 46 ) after removing the volume body ( 12 ) from the cornea ( 44 ). Further, the invention relates to a treatment apparatus ( 10 ), to a computer program product as well as to a computer-readable medium.

Ceramic compositions and processes for the manufacture and use thereof

This invention relates to ceramic compositions comprising a ceramic material such as alumina, clay, a dispersant and one or more block polymers characterized by an ABCBA structure as a binder, and to ceramics produced therefrom. This invention also relates to processes for the production of ceramic compositions and for the manufacture of ceramics. By using one or more block polymers characterized by an ABCBA structure as a binder, polymers of relatively high molecular weight can be used, thereby giving good green strength in the greenware, while still keeping the slurry viscosity relatively low. The ceramic compositions exhibit good green density, good mold release and gentle burnout character.

Ceramic compositions and processes for the manufacture and use thereof

Ceramic compositions and processes for the manufacture and use thereof

CERAMIC COMPOSITIONS AND PROCESSES FOR THE MANUFACTURE AND USE THEREOF Abstract This invention relates to ceramic compositions comprising a ceramic material such as alumina, clay, a dispersant and one or more block polymers characterized by an ABCBA structure as a binder, and to ceramics produced therefrom. This invention also relates to processes for the production of ceramic compositions and for the manufacture of ceramics. By using one or more block polymers characterized by an ABCBA structure as a binder, polymers of relatively high molecular weight can be used, thereby giving good green strength in the greenware, while still keeping the slurry viscosity relatively low. The ceramic compositions exhibit good green density, good mold release and gentle burnout character.

1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

Communication system for communicating with tags

A communication system for identifying, locating, tracking and communicating for other purposes with large numbers of tags in a time and energy efficient manner. The tags are associated with items located in a communication region that is interrogated by an interrogator on a one-to-many basis using broadcast commands, on a one-to-one basis using directed commands or on a combination basis using both methods. Identification occurs through organized transmission and reception of signals between the tags and the interrogator. A batch collection protocol uses a combined one-to-many and one-to-one communication system that effectively resolves communication contentions. The batch collection protocol employs a plurality of collection periods which communicate with large or unknown numbers of portable tags.

small liposomes for delivery of immunogen encoding RNA

lipossomas pequenos para entrega de rna que codifica imunogénio. imunização com ácido nucleio é obtida através da apresentação de rna encapsulado dentro de um lipossoma. o rna codifica um imunogénio de interesse, e o lipossoma tem um diâmetro no intervalo de 60-180nm, e idealmente na ordem de 80 160nm. assim, o invento proporciona um lipossoma com uma bicamada lipídica encapsulando um núcleo aquoso, em que: (i) a bicamada lipídica tem um diâmetro no intervalo de 60-180nm; e (ii) o núcleo aquoso compreende um rna que codifica um imunogénio. estes lipossomas são adequados para administração in vivo de rna para uma célula de vertebrado e assim eles são úteis como componentes de composições farmacêuticas para a imunização de indivíduos contra várias doenças. small liposomes for delivery of RNA encoding immunogen. Nucleic acid immunization is achieved by the presentation of encapsulated RNA within a liposome. rna encodes an immunogen of interest, and the liposome has a diameter in the range of 60-180nm, and ideally on the order of 80 160nm. Thus, the invention provides a liposome with a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer has a diameter in the range of 60-180nm; and (ii) the aqueous nucleus comprises an RNA encoding an immunogen. These liposomes are suitable for in vivo administration of RNA to a vertebrate cell and thus they are useful as components of pharmaceutical compositions for the immunization of individuals against various diseases.

Small omni-directional, slot antenna

This invention discloses a small slot antenna incorporated within a flat circuit board and having a three dimension omni-directional radiation pattern. In one embodiment, the antenna is formed as an L shaped slot along two edges of the circuit board of a miniature radio transceiver. The antenna is ideally suited for use in applications where radio frequency inventory tags (operating in the high VHF to low UHF frequency ranges of 400 to 500 mHz) are associated with items for which a high level of inventory control is required. It is important that such tags be able to communicate with vertical and horizontal polarized signals with reasonable gain. This invention features a low cost for manufacture and has application in radio communications in general wherever there is a requirement for a small transceiver with an integrated, orientation insensitive antenna.

Methods of treating breast cancer

A combination of agents for use in the treatment of triple negative breast cancer (TNBC) is disclosed. The combination of agents comprise: (i) a Bromodomain and Extra-Terminal motif (BET) inhibitor; and (ϋ) a proteasome inhibitor or an agent which downregulates the amount and/or activity of CXCRl/2 receptor.

Coarse scan and targeted active mode scan for touch

Power consumption of touch sensing operations for touch sensitive devices can be reduced by implementing one or more coarse scans to coarsely detect the presence or absence of an object touching or proximate to a touch sensor panel and dynamically adjusting the operation of the touch sensitive device to perform or not perform one or more steps of a fine scan based on the results of the one or more coarse scans. In some examples, the fine scan can be scheduled, and one or more steps of the fine scan can be aborted when no touch is detected at touch sensors scanned during the one or more steps. Sense channels unused due to the aborted fine scan steps can be powered down during aborted fine scan steps.

Pharmaceutical composition containing fixed dose combination of atenolol with isosorbide mononitrate

The present invention relates to a pharmaceutical composition containing fixed dose combination of atenolol with isosorbide mononitrate and process for the preparation thereof. The composition provides extended release of isosorbide mononitrate and immediate release of atenolol

Sting agonist comprising exosomes for treating neuroimmunological disorders

Provided herein are compositions comprising EV, e.g ., exosome, which comprises STING agonists and methods of using such compositions for the treatment of neuroimmunological disorders. Methods of producing the compositions ( e.g ., EVs comprising a STING agonist) described herein are also provided.

Methods of treating neuroinflammation

The present disclosure relates to extracellular vesicles, e.g ., exosomes, comprising an M2 polarization agent. In some aspects, the M2 polarization agent comprises an antisense oligonucleotide (ASO). Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.

Extracellular vesicle-nlrp3 antagonist

The present disclosure relates to extracellular vesicles, e.g, exosomes, comprising an NLRP3 antagonist. In some aspects, the NLRP3 antagonist comprises an antisense oligonucleotide (ASO). Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders, such as, for example, a peripheral neuropathy.

Process for the preparation of silodosin and its gamma form

The present invention provides an improved and efficient process for the preparation silodosin of formula I and pharmaceutically acceptable salts thereof Formula I. through novel tartrate salt of cyano hydroxy intermediate of formula II. Formula II The present invention also provides an improved, industrially advantageous and novel process for preparation of pure polymorphic form gamma (γ) of silodosin, wherein residual solvents are present in specified limits as per ICH guidelines. ·

Flexible scan plan using coarse mutual capacitance and fully-guarded measurements

A touch controller for flexible scanning operation is disclosed. The touch controller can include circuitry configured to perform coarse detection scans, select a fine scan type based on results from the coarse detection scans, and perform a fine scan corresponding to the selected fine scan type. A fine mutual capacitance scan can be performed when conditions corresponding to a poorly grounded or ungrounded object or user are detected based on the coarse detection scans. A fine fully-bootstrapped self-capacitance scan can be performed when conditions corresponding to a well-grounded object or user are detected based on the coarse detection scans. A touch processor can be configured to sense touch events from the fine scan.

Location-based swing compensation for touch channel attenuation

Location-based swing compensation for touch sensor panels can improve touch sensing performance. Due to differences in impedance characteristics of touch nodes at different locations in a touch sensor panel (due to differences in routing to touch nodes and due to differences in impedance with respect to ground (loading effects) of touch nodes), touch nodes can have non-uniform bandwidth characteristics which can manifest as non-uniform signal and signal-to-noise ratio (SNR) across the touch sensor panel. Additionally, the non-uniform signal can reduce the effectiveness of bootstrapping. Swing compensated stimulation signals can be applied to various touch nodes based on location and/or impedance characteristics of the various touch nodes. For example, the stimulation voltage can be increased for touch nodes with longer and/or thinner routing traces so that the signal at the touch node can be uniform with other touch nodes whose routing may be shorter and/or thicker. In some examples, a touch sensing system can include a swing compensation memory including swing compensation parameters to select stimulation signal swing for transmit channels.

Accessory id recognition by power cycling

Various embodiments are described herein for a peripheral device and a method of identifying the peripheral device via power cycling. In one embodiment, the method comprises obtaining characteristic information about the peripheral device, encoding the characteristic information in a power signal at the peripheral device and sending the power signal to an electronic device that is operably connected with the peripheral device. The electronic device can then take action such as adjusting its settings or applications based on the characteristic information of the peripheral device.

Bio-assisted treatment of ground contaminated by hydrocarbons, comprises isolating and adding micro-organisms that release oil from contaminated soil, adding oil degrading micro-organisms and nitrifying and ventilating the micro-organisms

Bio-assisted treatment of a ground contaminated by hydrocarbons, using a mixture of micro-organisms, comprises isolating the micro-organisms able to release oil from the contaminated soil/gravel particles, adding the micro-organisms in the ground to release oils, adding separately isolated micro-organisms able to degrade released oils, and making the provision of a nutritive substance optimized for the micro-organisms and the ventilation of the micro-organisms by periodically mixing the soil mixture contaminated by oil-water or by making smear of air to treat the contaminated ground.

Method and apparatus to reduce access time in synchronous fifos with zero latency overhead

The method and apparatus reduce access time in synchronous FIFOs with zero latency overheads. A FIFO buffer comprises FIFO means (301) storing 'n' data words, each 'm' bits wide, having an 'm' bit wide data input terminal. Furthermore, the FIFO buffer includes read data set selection means (303) connected to the data output terminals of the FIFO means and having two data output terminals providing simultaneous access to a selected storage location at an odd address and an even address. Odd read pointer generating means (304) provide the selection input to the data selection means (303) for selecting data at an odd read address of the read data selection means, while even read pointer generating means (305) provide the input for selecting data at an even read address. Multiplexing means (306) coupled to each of the two data output terminals of the read data set selection means select one of its outputs as the final output of the FIFO. State controlling means (310) coupled to the multiplexing means (306) control the selection of the final output and the selection input to the read data set selection means for selecting an odd read address and an even read address.

Method for bio-oxidative desulfurization of liquid hydrocarbon fuels and product thereof

Image-enabled item processing for point of presentment application

A financial transaction processing system for use at a point of presentment includes an input receptive of an image of a physical item at least partially embodying a financial transaction, wherein the image contains a visual record of an amount of monetary value. An image recognition module is adapted to extract the amount of monetary value recorded in the image and recognize the amount using character recognition. A validation module is adapted to determine whether the transaction is valid based on a validation characteristic of an item. A balancing module is adapted to determine whether the transaction is balanced based on the amount of monetary value. An output is adapted to transmit information indicating whether the transaction is at least one of balanced and valid.

Programmable integrated circuit architecture

A programmable logic device has a plurality of levels of programmable logic modules with fixed interconnections. The outputs of a level connect to inputs of the next level of programmable logic modules. The first level is fed from a bank of memory elements and the inputs to this bank of memory elements are derived from the last level. Crossbar switches are optionally inserted between a carefully chosen pairs of levels.

Ambient sound enhancement and acoustic noise cancellation based on context

An audio system has an ambient sound enhancement function, in which an against-the-ear audio device having a speaker converts a digitally processed version of an input audio signal into sound. The audio system also has an acoustic noise cancellation (ANC) function that may be combined in various ways with the sound enhancement function, and that may be responsive to voice activity detection. Other aspects are also described and claimed. 1/6 CNJo Vi-i

Method and system for preserving user identification when generating image data from a remote location

A method for a user using a thick client to send a print job to a server wherein the user name is preserved and can be determined by the server. When the image file is processed, the processing comprising appending a user identification to the file. A destination driver is invoked, which creates raw print data from the image file for each selected driver. The raw print data is sent to the server, wherein the server parses the raw data and determines the user identification. The raw print data can then be sent to the user's inbox on the server. In a preferred embodiment, the user identification comprises the sequence of ASCII 60 (or 3C hex), the username, and ASCII 62 (or 3E hex), or “<username>”. Preferably, the user identification is appended to the document name.

Method for maximization of artemisinin production by the plant artemisia annua

The invention provides a method for maximization of artemisinin yield of the plant Artemisia annua , said method comprising sowing seeds of Artemisia annua plant on raised bed nursery during second and third week of December and maintaining the moisture throughout; transplanting seedlings thus obtained bearing at least 5-15 leaves into the main field fertilized with fertilizer, preferably NPK @ 80,40,40 kg/ha to achieve a population density of 50,000 to 200,000 per ha followed by light irrigation in the second week of March and irrigation every fortnight thereafter; harvesting the crop four times by cutting the plant tops leaving 75-100 cm part of plant for further regeneration, the said harvests are performed in a manner that the first harvest is done in fourth week of May, second harvest in third week of July, third harvest in second week of September and fourth harvest in third week of October of each year; and at each harvesting time care is taken to care at least one green branch, and extracting artemisinin from the plant tissue immediately after each harvest.

A brain-computer interface test battery for the physiological assessment of nervous system health.

The systems and methods of the present invention comprise a battery of three or more sensory and cognitive challenge tasks which actively or dynamically challenge the brain to monitor its state for assessment of injury, disease, or compound effect, among others. Embodiments of the invention can provide systems and methods for analyzing and assessing a personalized biometric brain health signature by integrating the use of electroencephalography (EEG), somato-sensory, neuropsychological, and/or cognitive stimulation, and novel signal processing and display. Embodiments of the invention can provide systems and methods for early detection of dementia, including Alzheimer's disease (AD), vascular dementia (VAD), mixed dementia (AD and VAD), MCI, and other dementia-type disorders, as well as brain injury states such as mild Traumatic Brain Injury. Embodiments of the invention can provide some or all of the following improvements over conventional systems and methods, including: (1 ) Increased sensitivity, specificity, and overall accuracy; (2) early detection of disease and injury; and (3) enhanced portability with remote data acquisition capability. The present invention permits the overall assessment of health of the brain. Methods to assess the personalized biometric brain health signature are disclosed.

Personalized dynamic content via content tagging and transfer learning

Systems and methods are described for serving personalized content using content tagging and transfer learning. The method may include identifying content elements in an experience pool, where each of the content element is associated with one or more attribute tags, identifying a user profile comprising characteristics of a user, generating a set of user-tag affinity vectors based on the user profile and the corresponding attribute tags using a content personalization engine, generating a user-content affinity score based on the set of user-tag affinity vectors, selecting a content element from the plurality of content elements based on the corresponding user-content affinity score, and delivering the selected content element to the user.

Universal primers for wildlife identification

The invention provides novel universal primers that can amplify the fragment of cytochrome b gene of any animal species in polymerase chain reaction (PCR) and reveal the identity of the biological material of any unknown animal origin and a method for identification of the specific animal from a given biological sample.

Piezo-resistive transistor based resonator with ferroelectric gate dielectric

Describe is a resonator that uses ferroelectric (FE) materials in the gate of a transistor as a dielectric. The use of FE increases the strain/stress generated in the gate of the FinFET. Along with the usual capacitive drive, which is boosted with the increased polarization, FE material expands or contacts depending on the applied electric field on the gate of the transistor. As such, acoustic waves are generated by switching polarization of the FE materials. In some embodiments, the acoustic mode of the resonator is isolated using phononic gratings all around the resonator using the metal line above and vias' to body and dummy fins on the side. As such, a Bragg reflector is formed above the FE based transistor.

Context-based security over interfaces in O-RAN environments in mobile networks

Techniques for applying context-based security over interfaces in O-RAN environments in mobile networks are disclosed. In some embodiments, a system/process/computer program product for applying context-based security over interfaces in O-RAN environments in mobile networks includes monitoring network traffic on a mobile network at a security platform to identify a GTP-U tunnel session setup message associated with a new session; extracting a plurality of parameters from the GTP-U tunnel session setup message and from F1AP traffic to extract contextual information at the security platform; and enforcing a security policy at the security platform on the new session based on one or more of the plurality of parameters to apply context-based security to the network traffic transported between O-RAN Distributed Unit (O-DU) and O-RAN Centralized Unit Control Plane (O-CU-CP) nodes in an O-RAN environment in the mobile network.

Use of Female Mammal's Urine for Determination of Fetal Gender Related Characteristics

The present invention provides a method for determining the gender of a fetus by assaying the sex hormones, evaluating the overall reducing/oxidizing (redox) activity, and/or evaluating the radical scavenging capacity of the maternal urine or other body fluid. The method can be used to determine fetal gender at any time point during the entire pregnancy. The body fluid may be processed before assaying. Processing may involve aging the body fluid, or purification of various fractions. The methods of the present invention also provide for a means for pre-conception offspring gender planning by assaying the sex hormones, evaluating the overall reducing/oxidizing (redox) activity, and/or evaluating the radical scavenging capacity of the urine or other body fluid from a non-pregnant female. The sex hormone profiles, the overall redox activity, and/or the radical scavenging capacity of a urine sample correlates with the gender specific compatibility of the ovum being released during a particular menstrual cycle. Therefore, assaying aforementioned parameters from a non-pregnant female's urine will help a couple or an animal breeder have an offspring of a desired gender. The present invention also provides a method of conceiving a baby of a desired gender in a female by applying to the female a pharmaceutical formulation with a specific sex hormone composition.

Hollow body having a wall of glass with a surface region having contents of si and n

The invention refers to a hollow body (100) comprising a wall of glass (101) which at least partially surrounds an interior volume (102) of the hollow body (100); wherein the wall of glass (101) has a wall surface (103), which comprises a surface region (104); wherein at least in the surface region (104) the wall surface (103) has a content of a) N in a range from 0.3 to 10.0 at-%, and b) Si at least 5 at-%, wherein the preceding contents are determined by an X-ray photoelectron spectroscopy. Further, the invention refers to a process (300) for making an item and a hollow body (100) obtainable thereby; to a closed container (200); to a process (300) for packaging a pharmaceutical composition (201); to a closed hollow body (200) obtainable by this process (300); to a use of a hollow body (100) for packaging a pharmaceutical composition (201); and to a use of composition comprising N.

Process for producing biodiesel and the product thereof

Method and apparatus for bandwidth provisioning in a wlan

The invention provides for a receiver transmitter comprising: a plurality of logical access points; for downloading a duration into a mobile terminal in accordance with an access point determination of the maximum amount of time information linked with a downlink broadcast traffic to deliver all the broadcast/multicast information in a single communication stream. The invention also provides for a method of broadcast/multicast frames 'Duration' are set to values in order to deliver all the broadcast/multicast information in a single communication stream eliminating the requirement for contending for the medium for each broadcast/multicast frame transmission. This pseudo-reservation of the wireless medium can also be made periodic for enabling broadcast/multicast services.

Lubricity improving additive composition for low sulfur diesel fuel

The present invention relates to a additive composition for use as lubricity improver for low sulphur diesel, comprising e) 0.1-10% by weight of ester derivative derived from cashew nut shell liquid (CNSL esters) of formula (I); f) 0.1 - 10% by weight of ester derivative derived from cashew nut shell liquid of formula (II); g) 50-95% by weight of free fatty acid of the formula RCOOH in which R represents an alkyl/alkenyl group with 12 to 24 carbon atoms. h) 1-30% by weight of synthetic esters derived by esterifying tri, tetra, penta hydric alcohols with carboxylic acids such as lauric, palmitic, linoleic, ricinoleic etc.

Communication services

An advanced intelligent communication system that provides subscriber-requested, advanced communication services through existing communication switches even in those circumstances in which the hardware communication switch is not configured to provide such communication services. The system supports the use of personal identification number access cards for use in fixed and mobile markets from any communication device located anywhere in the world and provides flexible call processing and switching services that deliver enhanced computer telephony capabilities utilizing standard communication equipment and operating systems.

Built-in television console antenna

Two single turn horizontally oriented loops are located in a common plane inside a television receiver cabinet. A multiposition switch is used to connect the loops in various combinations to the receiver antenna terminals. In a typical receiver, employing separate VHF and UHF tuner inputs a fourposition switch is employed. In one position one loop is connected to the VHF input and the other is connected to the UHF input. In the second position the loops are exchanged. In the third position both loops are connected to the VHF input and in the fourth position both loops are connected to the UHF input. Thus for either VHF or UHF reception the user has a selection of three switch positions for optimum signal pickup.