27-11-2014 дата публикации
Номер: US20140349970A1
Автор:
Argiriadi Maria A.,
Breinlinger Eric C.,
Calderwood David J.,
Ericsson Anna M.,
FIAMENGO Bryan A.,
Frank Kristine E.,
Friedman Michael,
George Dawn M.,
GOEDKEN Eric R.,
Hoemann Michael Z.,
JOSEPHSOHN Nathan S.,
LI Biqin C.,
Morytko Michael J.,
Mullen Kelly D.,
Somal Gagandeep,
Stewart Kent D.,
VOSS Jeffrey W.,
Wallace Grier A.,
Wang Lu,
WISHART Neil,
Woller Kevin R.
The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions. 2. The compound of wherein{'sup': 1', 'a', 'b', 'a', 'b, 'sub': 3', '3', '1', '6', '3', '6', '1', '6', '2', '1', '6', '2', '1', '6, 'Ris H, halogen, CF, CN, OH, N(R)(R), OCF, —C(O)-optionally substituted (C-C)alkyl, —C(O)-optionally substituted (C-C)cycloalkyl, —S-optionally substituted (C-C)alkyl, —S(O)-optionally substituted (C-C)alkyl, —S(O)N(R)(R), optionally substituted (C-C)alkoxy, optionally substituted azaindolyl, optionally substituted azepinyl, optionally substituted azetidinyl, optionally substituted benzo(b)thienyl, optionally substituted benzofuranyl, optionally substituted benzimidazolyl, optionally substituted benzoxazolyl, optionally substituted benzothiazolyl, optionally substituted benzothiadiazolyl, optionally substituted benzoxadiazolyl, optionally substituted 6,7-dihydro-5H-cyclopentapyrimidinyl, optionally substituted furanyl, optionally substituted imidazolyl, imidazopyridinyl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazinyl, 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazinyl, 5,6,7,8-tetrahydro[1,2,4]-triazolo[4,3-a]pyrazinyl, optionally substituted indazolyl, optionally substituted indolinyl, optionally substituted indolyl, optionally substituted isoindolinyl, optionally substituted isoxazolyl, optionally substituted isothiazolyl, optionally substituted morpholinyl, optionally substituted oxadiazolyl, optionally substituted oxazolyl, optionally substituted phenyl, optionally substituted piperazinyl, optionally substituted piperidinyl, optionally substituted purinyl, optionally substituted pyranyl, optionally substituted pyrazolyl, optionally substituted pyrazolo[3,4-d] ...
Подробнее
