HYDRAULIC DRIVING MECHANISM TO ROTATE a FOREUSEAU ROCK

MANUFACTORING PROCESS OF LAYERS OF CHEMICO-MECANICAL POLISHING

La présente invention concerne un procédé de fabrication de couches de polissage pour une utilisation dans des tampons de polissage chimico-mécanique, une pluralité de couches de polissage étant dérivée d'une galette, la formation de défauts de densité dans la galette et la rugosité de surface des couches de polissage formées étant minimisées.

PROCESS AND APPARATUS FOR THE PRODUCTION OF LEAD 212 HAVE MEDICAL USE

L'invention se rapporte à un procédé qui permet de préparer du plomb 212 à usage médical. Ce procédé comprend la production de plomb 212 par décroissance de radium 224 dans un générateur comprenant un milieu solide sur lequel est retenu le radium 224, suivie de l'extraction du plomb 212 du générateur sous la forme d'une solution aqueuse A1, et est caractérisé en ce que le plomb 212 contenu dans la solution aqueuse A1 est purifié vis-à-vis des impuretés radiologiques et chimiques que contient également cette solution par une chromatographie en phase liquide sur colonne. L'invention se rapporte également à un appareil spécialement conçu pour la mise en œuvre automatisée et en système fermé dudit procédé. Elle se rapporte en outre au plomb 212 produit au moyen de ce procédé et de cet appareil. Applications : fabrication de radiopharmaceutiques à base de plomb 212, utiles en médecine nucléaire, pour le traitement de cancers, notamment par radio-immunothérapie α, ou pour l'imagerie médicale, ...

ASSEMBLY Of SEALING SEGMENTS

Systèmes et dispositifs destinés à rendre étanches des parties de machines tournantes. Selon un mode de réalisation, un élément d'assemblage d'étanchéité (210, 211) comprend une bride de tête (216) et un col axial (218) relié à la bride de tête (216). Le col axial (218) comprend une bride conjuguée (252, 275) qui s'étend sur la circonférence, depuis une extrémité distale de l'élément d'assemblage d'étanchéité (210, 211). La bride conjuguée (252, 275) est configurée pour former un joint d'étanchéité multidirectionnel avec une partie en retrait (242) d'un élément d'assemblage d'étanchéité (210, 211) complémentaire. L'élément d'assemblage d'étanchéité comprend également un ensemble de dents d'étanchéité axiales (270) reliées au col axial (218).

PROCESS ALLOWING TO IDENTIFY COMBINE ACTIVE IN a SYSTEM OF CORDLESS PHONE

CARBON NANOTUBE SENSOR

METHOD AND APPARATUS FOR PRODUCING MEDICAL LEAD 212

NEUE EXENDIN AGONIST FORMULIERUNGEN UND DEREN VERABREICHUNG

PROCESS FOR PRODUCING LAYERS OF MECHANISM WITH A WINDOW

REMOTE CONTROL OF SENSOR IN CARBON NANOTUBE

La présente invention fournit un système de contrôle à distance destiné à contrôler le fonctionnement d'un système de traitement de fluide et/ou les qualités, caractéristiques, propriétés, etc., du fluide transformé ou traité par le système de traitement de fluide. La présente invention concerne également des capteurs en nanotube de carbone.

TRACTOR TO MOVE AND APPLY UNDER PRESSURE BY ORDER HAS DISTANCEUNE DRILLING MACHINE WITH THE ROCK

MANUFACTORING PROCESS OF LAYERS OF CHEMICO-MECANICAL POLISHING

Un procédé de fabrication de couches de polissage pour l'utilisation dans les tampons de polissage chimico-mécanique est produit, dans lequel la formation de défauts de densité dans les couches de polissage est réduite au maximum. Pour préparer une couche de polissage, on introduit un mélange thermodurcissable dans la cavité (20) d'un moule ayant une zone de type trou de tore (40) et une zone de type tore (50), par une buse dont l'orifice se déplace par rapport à la base du moule, selon une phase initiale dans laquelle l'orifice est dans la zone de type trou de tore, une phase de transmission dans laquelle l'orifice passe à la zone de type tore et une phase restante dans laquelle l'orifice est dans la zone de type tore.

PROCESS FOR PRODUCING LAYERS OF CHEMICAL MECHANICAL POLISHING

PREVENTING SURGE IN A SYSTEM FOR GENERATING ELECTRIC POWER AIRCRAFT

SYSTEM AND METHOD FOR RECORDING A FINGERPRINT OF PARAMETERIZATION METHOD FOR OPENING ANY APPLICATION SESSION AND LOG OF THE APPLICATION.

SYSTEM AND PROCESS Of RECORDING Of a DIGITAL FINGERPRINT OF PARAMETER SETTING Of a PROCESS Of OPENING OF SESSION Of an APPLICATION AND OPENING Of a SESSION OF the APPLICATION.

L'invention concerne des systèmes (1) et des procédés pour enregistrer des empreintes digitales, paramétrer un procédé d'ouverture de session pour une application et ouvrir une session de l'application. Dans la phase d'enregistrement, le système reçoit un signal d'empreinte digitale, qui est attribué à l'une des nombreuses données liées aux doigts. Dans la phase de paramétrage du procédé d'ouverture de session, le système détecte un signal d'ouverture de session, qui comprend une identité, un mot de passe et une instruction pour exécuter l'application. Le système commande l'affichage des données liées aux empreintes digitales et reçoit un message de sélection correspondant à l'une des données liées aux doigts. Le système attribue l'application, l'identité, le mot de passe aux données liées aux empreintes digitales sélectionnées. Dans la phase d'ouverture de session, le système reçoit le signal d'empreinte digitale et, de cette façon, extrait l'application correspondante, l'identité correspondante ...

MANUFACTORING PROCESS OF LAYERS OF CHEMICO-MECANICAL POLISHING INCLUDING/UNDERSTANDING A WINDOW

La présente invention concerne un procédé de fabrication de couches de polissage comprenant une fenêtre pour une utilisation dans des tampons de polissage chimico-mécanique, une pluralité de couches de polissage comprenant une fenêtre intégrale étant dérivée d'une galette, la formation de défauts de densité dans la galette et la rugosité de surface des couches de polissage formées étant minimisées.

PREVENTION OF OVERPRESSURES IN a SYSTEM OF GENERATION Of Electrical energy Of PLANE

Un exemple de procédé de détection d'une condition de surtension de génératrice comprend prédire un courant de commande primaire pour fournir un courant de commande prédit, surveiller le courant de commande primaire, et détecter une condition de surtension de génératrice sur la base d'une comparaison entre le courant de commande prédit et le courant de commande primaire. Le procédé interrompt le courant de commande primaire sur la base de la comparaison.

SENSOR IN CARBON NANOTUBE

La présente invention fournit un système de surveillance à distance destiné à surveiller le fonctionnement d'un système de traitement de fluide et/ou les qualités, caractéristiques, propriétés, etc., du fluide transformé ou traité par le système de traitement de fluide. La présente invention concerne également des capteurs en nanotube de carbone.

APPARATUS FOR DIVERTING PIECES OF FOOD SOLID SUSPENDED IN A FLOWING LIQUID.

PROCESS FOR PRODUCING LAYERS OF CHEMICAL MECHANICAL POLISHING

ACTIVE SUPPRESSION AND INSULATION OF VIBRATIONS WITH REACTION AND ANTEREACTION FOR a FRAME OF ENGINE Of PLANE

Une structure de bâti moteur (300) est pourvue de mécanismes anti-vibrations actifs (36) qui sont fixés au voisinage du bâti moteur (30) pour empêcher des vibrations du moteur de se propager jusque dans la structure de support (32) du moteur, par exemple la structure de l'aile ou de fuselage d'un avion. De plus, des détecteurs (40/42) sont disposés sur le moteur (34) et/ou la structure de l'aile/fuselage (32) pour fournir des signaux de commande aux mécanismes anti-vibrations actifs (36) de façon que le mécanisme anti-vibrations actifs réagisse aux données détectées pour limiter le plus possible la transmissibilité de vibrations du moteur (34) à la l'aile/au fuselage (32).

ACTIVE VIBRATION SUPPRESSION AND ISOLATION AND ANTEREACTION WITH FEEDBACK FOR AN AIRCRAFT ENGINE MOUNT

SEGMENTED SEAL ASSEMBLY

APPARATUS FOR DIVERTING PIECES OF FOOD SOLID SUSPENDED IN A FLOWING LIQUID.

Valve de distribution pour un système d'hydrocoupe. La valve dévie automatiquement un écoulement de liquide et de produits alimentaires solides s'écoulant à partir d'une source vers l'une ou les deux de deux destinations. Un conduit d'entrée reçoit les produits alimentaires en suspension dans le liquide, et une plaque coudée dévie les produits alimentaires vers le bas. Les produits alimentaires et le liquide pénètrent dans un tambour qui est perpendiculaire au conduit d'entrée, provoquant une circulation rotative dans le tambour. Les produits alimentaires et le liquide s'écoulent dans l'une ou les deux des deux sorties longitudinalement opposées, selon que la trajectoire en aval des sorties s'écoule. Suite à l'actionnement d'une valve d'un côté ou le blocage essentiellement complet d'un côté, le fluide et les produits s'écoulent de l'autre côté automatiquement. Aucune partie mobile n'est nécessaire dans la valve pour changer la trajectoire d'écoulement; le seul changement est l'écoulement ...

Unlösliche Proteinpartikel

VERWENDUNG VON EXENDINEN UND DEREN AGONISTEN ZUR BEHANDLUNG VON HYPERTRIGLYCERIDÄMIE

HERBICIDE

METHOD FOR OBTAINING OF NITROCOMPOUNDS

Surgical system entry guide

An entry guide tube and cannula assembly, a surgical system including the assembly, and a method of surgical instrument insertion are provided. In one embodiment, the assembly includes a cannula having a proximal portion that operably couples to an accessory clamp of a manipulator arm, and a distal tubular member coupled to the proximal portion, the tubular member having an opening for passage of at least one instrument shaft. The assembly also includes an entry guide tube rotatably coupled to the proximal portion of the cannula, the entry guide tube including a plurality of channels for passage of a plurality of instrument shafts, wherein the entry guide tube is rotatably driven relative to the proximal portion of the cannula by rotation of at least one instrument shaft about a longitudinal axis of the entry guide tube.

Optical instrument comprising multi-notch beam splitter

An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.

System and methods for wireless firmware upgrades using one-way broadcast transmissions

Methods and systems for wireless firmware upgrades are provided. In one embodiment, a system comprises: at least one master source radio and one or more client radio devices in wireless communication with the master source radio. The master source radio transmits a firmware image block broadcast to the client radio devices comprising sequentially transmitted firmware image blocks, wherein the master source radio transmits each block a plurality of times. Each of the plurality of sequentially transmitted firmware image blocks is transmitted as payload within a broadcast block, the broadcast block further comprising metadata associated with the payload. The client radio devices each include a firmware memory and a boot loader. The boot loader assembles a firmware image from the firmware image block broadcast and stores the firmware image into the memory. Transmission of the firmware image block broadcast is not controlled using feedback from the client radio devices.

Penicillin-binding protein inhibitors

Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Preloaded surgical instrument interface

A surgical system ( 200 ) includes a surgical instrument ( 260 ) that is sensitive to backlash that would adversely affect the transmission of controlled torque and position to the surgical instrument. The surgical instrument ( 260 ) is coupled to motors in a surgical instrument manipulator assembly ( 240 ) via a mechanical interface. The combination of the mechanical interface and surgical instrument manipulator assembly ( 240 ) have low backlash, e.g., less than 0.7 degrees. The backlash is controlled in the surgical instrument manipulator assembly ( 240 ). From the drive output disk ( 545 ) in the surgical instrument manipulator assembly to the driven disk ( 964 ) of the surgical instrument, the mechanical interface has zero backlash for torque levels used in surgical procedures.

Surgical system instrument manipulator

An instrument manipulator and a robotic surgical system including an instrument manipulator are provided. In one embodiment, an instrument manipulator includes a plurality of independent actuator drive modules, each of the plurality of actuator drive modules including an actuator output, wherein each of the actuator outputs are configured to independently actuate a corresponding actuator input of a surgical instrument without force input from another actuator output. The instrument manipulator further includes a frame housing the plurality of independent actuator drive modules, the frame including a distal end from which each of the actuator outputs distally protrude for engaging the corresponding actuator inputs of the surgical instrument.

Position sensor assembly

A position sensor assembly comprising ( 15 ) a housing ( 16 ) having a least one inner cavity, a stator ( 22 ) disposed within the housing, a moving element ( 23 ) disposed within the housing and configured and arranged to move relative to the stator ( 22 ), the stator comprising primary windings ( 24 ) and secondary windings ( 25, 26 ), the secondary windings configured and arranged to provide an output signal ( 27 ) as a function of movement of the moving element ( 23 ) relative to the stator ( 22 ), electronics ( 28 ) disposed in the housing and communicating with the primary windings ( 24 ) and the secondary windings ( 25, 26 ), the electronics comprising an integrated circuit ( 29 ) configured and arranged to provide excitation of the primary windings ( 24 ) and to demodulate the output signal ( 27 ) of the secondary windings ( 25, 26 ), and an input element ( 35 ) extending through the housing ( 16 ) and connected to the moving element ( 23 ).

Apparatus and Method for Differentiating Multiple Fluorescence Signals by Excitation Wavelength

An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.

Syringe products and related methods and uses

Non-corrosive cleaning composition for removing plasma etching residues

A non-corrosive cleaning composition for removing plasma etching residues having a pH from 2 to 6 and comprising: (A) water; (B) at least one selected hydroxylammonium compound; and (C) at least one basic compound; and optionally (D) a chelating stabilizer; and optionally (E) a surfactant.

Cleaning composition and method for removing residues

Non-corrosive cleaning compositions that are aqueous based and useful for removing photoresist, plasma etch and CMP residues from a substrate. One preferred cleaning composition comprises: (i) a hydroxylamine or a hydroxylamine salt compound;(ii) at least one fluorine-containing compound; and (iii) water. Another cleaning composition comprises: (i) a compound selected from the group consisting of: an amine, a quatenary ammonium hydroxide, and ammonium hydroxide; (ii) at least one fluorine-containing compound; and (iii) water.

Cleaning composition and method for removing residues

Non-corrosive cleaning compositions that are aqueous based and useful for removing photoresist, plasma etch and CMP residues from a substrate. One preferred cleaning composition comprises: (i) a hydroxylamine or a hydroxylamine salt compound; (ii) at least one fluorine-containing compound; and (iii) water. Another cleaning composition comprises: (i) a compound selected from the group consisting of: an amine, a quatenary ammonium hydroxide, and ammonium hydroxide; (ii) at least one fluorine-containing compound; and (iii) water.

An optical instrument monitoring dna polymerase chain reactions

An optical instrument (A) for monitoring polymerase chain reaction replication of DNA may include a thermal cycler block (1c) for holding a plurality of vials (1b), each containing a suspension of ingredients that include a fluorescent primary dye. The instrument may include a light source (11) for emitting a source beam, a first means (7) disposed to be receptive of the source beam, a primary focusing means (3) disposed to focus the excitation beam simultaneously into a plurality of suspensions and being receptive of and passing emission beams, a second means (8) disposed to be receptive of emission beams, an emission focusing means (10) for focusing emission beams, a detector, and a processing means for computing concentration of DNA. The optical system being arranged without a beam splitter (6) but with one or more folding mirrors (5), and with excitation and emission beams being on slightly different optical paths angularly.

Optical instrument comprising multi-notch beam splitter

An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.

Instrument for monitoring polymerase chain reaction of DNA

An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

Polyethylenically unsaturated polycarbonate polymers

Enteral bottle cap with vent valve

A connection component (10) suitable for use with an enteral fluid delivery set wherein the connection component (10) consists of a threaded cap having a projecting spike (32) thereon to penetrate and deform a foil diaphragm on the fluid container and further including an air passageway (30) having a flexible member (38) therein to allow filtered air to flow into the fluid container while preventing the flow of fluid from the fluid container through the air passageway (30).

Peristaltic infusion device with backpack sensor

The present invention relates to a sensed member and sensing member for use on a medical fluid infusion device and support device wherein the fluid infusion device is usable in a conventional manner such as on an IV pole and in an ambulatory manner such as in a support device for use in an ambulatory backpack. The sensing member of the present invention detects when the fluid infusion device is to be used in an ambulatory manner to adjust the operation of the infusion control member to account for the difference in fluid flow rates caused by the different fluid pressures within the fluid delivery set when the fluid infusion device is used in a conventional manner and an ambulatory manner.

Syringe products and related methods and uses

A syringe product (40) comprises a syringe barrel (42) having a fluid- containment wall (48) made using a polymer composition comprising a metallocene polypropylene polymer and an organophosphate clarifier. The syringe product may be prefilled with an injectable medical formulation (62) prior to use. The syringe product may be used to administer an injectable medical formulation to a patient.

Ethylene oligomerization process

ABSTRACT ETHYLENE OLIGOMERIZATION PROCESS Process for the conversion of ethylene to n-alpha-olefin oligomers by contact with a catalytic nickel complex dissolved in a polar diol-based solvent, containing between 0.5 and 4.0 per cent by weight of water, calculated on diol.

Supported nickel catalysts and process for their preparation

ABSTRACT OF THE DISCLOSURE Highly effective supported nickel catalysts having finely divided metallic nickel deposited thereon and high specific metal surface areas are obtained by a process wherein a support material is contacted with a nickel soap in an inert hydrocarbon and the resulting nickel-bearing support subsequently subjected to a sulphiding step followed by reductive treatment. Such catalyst compositions typically containing 25% to 75% by weight nickel and having a surface area from 100 m2/g to 800 m2/g are useful as hydrogenation catalysts, particularly for the hydrogenation of fatty materials.

Continuous process for polymerizing polyethylene

Syringe products and related methods and uses

A syringe product (40) comprises a syringe barrel (42) having a fluid- containment wall (48) made using a polymer composition comprising a metallocene polypropylene polymer and an organophosphate clarifier. The syringe product may be prefilled with an injectable medical formulation (62) prior to use. The syringe product may be used to administer an injectable medical formulation to a patient.

Syringe products and related methods and uses

A syringe product (40) comprises a syringe barrel (42) having a fluid- containment wall (48) made using a polymer composition comprising a metallocene polypropylene polymer and an organophosphate clarifier. The syringe product may be prefilled with an injectable medical formulation (62) prior to use. The syringe product may be used to administer an injectable medical formulation to a patient.

Productos de jeringuilla y métodos y usos relacionados

Un producto de jeringa (40), que comprende: un cilindro de la jeringa (42) que comprende una pared de confinamiento de fluido (48) y un volumen interno (52) definido al menos en parte por la pared; un émbolo de jeringa (50) dispuesto de forma móvil en el interior del volumen interno y que se puede desplazar dentro del volumen interno para realizar al menos uno de crear una succión de fluido dentro de al menos una parte del volumen interno y crear presión de fluido dentro de al menos una parte del volumen interno; consistiendo la pared del cilindro de la jeringa esencialmente de una composición de polímero que comprende un polímero de polipropileno metaloceno y un clarificador de organofosfato; caracterizado por que la composición de polímero comprende al menos un 98 por ciento en peso del polímero de polipropileno metaloceno; y el polímero de polipropileno metaloceno es un homopolímero de polipropileno.

Syringe products and related methods and uses

A syringe product (40) comprises a syringe barrel (42) having a fluid- containment wall (48) made using a polymer composition comprising a metallocene polypropylene polymer and an organophosphate clarifier. The syringe product may be prefilled with an injectable medical formulation (62) prior to use. The syringe product may be used to administer an injectable medical formulation to a patient.

Beta-lactamase inhibitors

Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Penicillin-binding protein inhibitors

Penicillin-binding protein inhibitors

Oligomerization reaction system

Ethylene is oligomerized to even numbered alpha-monoolefins, predominantly in the range up to about C 40 , by contact at elevated pressure with nickel complex catalysts dissolved in polar organic solvents, preferably certain diols. In the recovery of oligomers from the reaction product of this process, the ethylene-containing liquid oligomer product phase, after separation from the liquid solvent phase, is scrubbed with a clean portion of the organic solvent to remove catalyst complex, which may be recycled to the reaction zone. Such catalyst removal prevents polyethylene formation during further processing of the product, thus avoiding fouling of process equipment and improving ethylene utilization as well as catalyst utilization.

Security toner and process of using thereof

The present disclosure relates to toner compositions containing an IR-taggant, and method of making thereof. The disclosure also relates to method for confirming authenticity of an item.

Imaging system

An electrostatographic developer mixture comprising finely-divided positively charging toner particles electrostatically clinging to negatively charging carrier particles. The toner particles comprise a resin, a colorant, and a charge inducing material selected from (1) a long chain hydrazinium compound and (2) an alkyl pyridinium compound. The carrier particles comprise core particles having a coating of fused thermoplastic resin particles wherein the carrier particles are prepared by dry-mixing the core particles with thermoplastic resin particles until the resin particles adhere to the core particles. The mixture of core and resin particles are heated to between 320° F. and 650° F. for between 20 and 120 minutes so that the resin particles melt and fuse to the core particles. The developer mixture is employed to develop electrostatic latent images.

Electrostatographic developer mixture including a long chain hydrazinium or an alkyl pyridinium compound as charge inducing material

ABSTRACT OF THE DISCLOSURE An electrostatographic developer mixture comprising finely-divided positively charging toner particles electrostatically clinging to negatively charging carrier particles. The toner particles comprise a resin, a colorant, and a charge inducing material selected from (1) a long chain hydrazinium compound and (2) an alkyl pyridinium compound. The carrier particles comprise core particles having a coating of fused thermoplastic resin particles wherein the carrier particles are prepared by dry-mixing the core particles with thermoplastic resin particles until the resin particles adhere to the core particles. The mixture of core and resin particles are heated to between 320°F. and 650°F. for between 20 and 120 minutes so that the resin particles melt and fuse to the core particles. The developer mixture is employed to develop electrostatic latent images.

Method and apparatus for real time detection of nucleic acid amplification products

A system is provided for carrying out real time fluorescence-based measurements of nucleic acid amplification products. In a preferred embodiment of the invention, an excitation beam is focused into a reaction mixture through a surface, the reaction mixture containing: (i) a first fluorescent indicator capable of generating a first fluorescent signal whose intensity is proportional to the amount of an amplification product in the volume of the reaction mixture illuminated by the excitation beam and (ii) a second fluorescent indicator homogeneously distributed throughout the reaction mixture capable of generating a second fluorescent signal proportional to the volume of reaction mixture illuminated by the excitation beam. Preferably, the excitation beam is focused into the reaction mixture by a lens through a portion of a wall of a closed reaction chamber containing the reaction mixture. The same lens is used to collect the first and second fluorescent signals generated by the first and second fluorescent indicators, respectively, in response to the excitation beam. The ratio of the fluorescent intensities of the first and second fluorescent signals provides a stable quantitative indicator of the amount of amplification product synthesized in the course of the amplification reaction.

Skate wheel structure

Fusion of bicyclic 2,4-diaminopyrimidine derivatives as using ALK and c-Met inhibitors

Un compuesto de fórmula I o II **Fórmula** o una forma de sal farmacéuticamente aceptable de las mismas, en la que R1 es cloro; R2 es un grupo seleccionado entre alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo C6-15, cicloalquilo C3-10, heterocicloalquilo de 3-15 miembros, y heteroarilo de 5-15 miembros, en la que el grupo R2 se sustituye opcionalmente por uno o más miembros seleccionados independientemente entre halógeno,-NO2, -OR20, >=O, - C(>=O)R20, -C(>=O)OR20, -C(>=O)NR22R23, -NR20R21, alquilo C1-6-(R25)x, arilo C6-15-(R25)x, heteroarilo de 5-15 miembros-(R25)x, cicloalquilo C3-10-(R25)x, heterocicloalquilo de 3-15 miembros-(R25)x, pseudohalógeno, - S(>=O)nR20, -S(>=O)2NR22R23, -OCH2F, -OCHF2, -OCF3, NHOH, -OC(>=O)R20, OC(>=O)NR22R23, - NR20C(>=O)R21, -NR20C(>=O)OR21, -NR20S(>=O)2R21, NR20C(>=O)NR22R23, -NR20S(>=O)2NR22R23, y -SCF3; R3, R4, y R5 se seleccionan independientemente entre H, halógeno, -NO2, -OR30,-C(>=O)R30, -C(>=O)OR30, - C(>=O)NR32R33, -NR30R31, alquilo C1-6-(R35)x, arilo C6-15-(R35)x, heteroarilo de 5-15 miembros-(R35)x, cicloalquilo C3-10-(R35)x, heterocicloalquilo de 3-15 miembros-(R35)x, pseudohalógeno, -S(>=O)nR30, - S(>=O)2NR32R33, -OCH2F, -OCHF2, -OCF3, NHOH, -OC(>=O)R30, -OC(>=O)NR32R33, NR30C(>=O)R31, - NR30C(>=O)OR31, -NR30S(>=O)2R31, - NR30C(>=O)NR12R33, -NR30S(>=O)2NR32R33, y -SCF3; A1, A2, A3, A4, y A5 son independientemente cada uno -CZ1Z2-, -(CZ1Z2)2- -C(>=O)-,-NZ3-, -S-, -S(>=O)-, -S(>=O)2-, o -O-, con la condición a lo sumo de A1, A2, A3, A4, y A5 es -(CZ1Z2)2-, en el que: (a) cuando cualquiera de Z1, Z2, y Z3 se encuentra en átomos adyacentes, pueden formar un enlace entre los átomos, (b) cualquiera de Z1, Z2, y Z3 se puede seleccionar independientemente entre H, halógeno,-NO2, -OR40, - C(>=O)R40, -C(>=O)OR40, -C(>=O)NR42R43, -NR40R41, alquilo C1-6-(R45)x, arilo C6-15-(R45)x, heteroarilo de 5-15 miembros-(R45)x, cicloalquilo C3-10-( ...

Nuclear reactor fuel rod thermal simulator

The tubular stainless steel structure of a nuclear reactor fuel rod thermal simulator is heated to nuclear fuel rod operating temperatures by means of a gaseous glow discharge established within the tubular structure. In a preferred embodiment a length of the simulated fuel rod is internally clad with tungsten, or Mo or alloys thereof, hermetically sealed at both ends and filled with a glow discharge sustaining gas such as hydrogen or helium. A center electrode structure, as of tungsten, or Mo or alloys, is centrally disposed within the gas filled tubular envelope. Power is applied between the center electrode and the outer tubular envelope for initiating and sustaining the glow discharge for heating the outer tubular envelope to nuclear fuel rod simulating temperature.

Instrument for monitoring nucleic acid sequence amplification reaction

An instrument is provided that can monitor nucleic acid sequence amplifications reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.

Instrument for monitoring polymerase chain reaction of dna

An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

Instrument for monitoring polymerase chain reaction of DNA

An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

Optical instrument including excitation source

An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed along a beam path between the light source and the reaction regions to form bundles of collimated excitation beams, wherein each bundle corresponds to a respective reaction region. Methods of analysis using the optical instrument are also provided.

Optical instrument including excitation source

An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.

Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength

An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.

Starch ethers containing nitrogen and process for making the same

Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors

The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , A 1 , A 2 , A 3 , A 4 , and A 5 , are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

Process for the preparation of secondary alcohol sulfate-containing surfactant compositions

This invention relates to a process for preparing secondary alkyl sulfate-containing surface active compositions substantially free of unreacted organic matter and water, which process comprises: a) sulfating a detergent range olefin having from about 8 to about 22 carbon atoms with concentrated sulfuric acid, b) neutralizing the product of step a) with a base dispersed in a nonionic surfactant having a boiling point higher than that of said detergent range olefin and its corresponding secondary alcohol, c) saponifying the product of step b), d) passing the product of step c) through a thin film evaporator to evaporate unreacted organic matter from said product and recovering said product.

Scanning system and method for scanning a plurality of samples

A system for detecting fluorescence emitted from a plurality of samples in a sample tray is provided. The system generally includes a plurality of lenses positioned in a linear arrangement, a linear actuator configured to translate the plurality of lenses, an excitation light source for generating an excitation light, an excitation light direction mechanism for directing the excitation light to a single lens of the plurality of lenses at a time so that a single sample holder aligned with the lens is illuminated at a time, and an optical detection system for analyzing light from the sample holders. In certain embodiments, the optical detection system includes a light dispersing element configured to spectrally disperse the light from the sample holder being illuminated, and a lens element configured to receive light from the light dispersing element and direct the light onto a light detection device. A method of scanning a sample tray having a plurality of samples positioned in sample holders to detect fluorescence is also provided.

Removable infinite roll master grip handle and touch sensor for robotic surgery

An input device for robotic surgery mechanically transmits a grip signal across a first joint coupling a handle to a linkage supporting the handle. The handle is removable and replaceable, allows unlimited rotation about the joint, and may optionally include a touch sensor to inhibit movement of a surgical end effector when the hand of the surgeon is not in contact with the handle.

Retrograde instrument

A minimally invasive surgical instrument includes a U-turn mechanism that transmits actuating forces around a U-turn. The U-turn mechanism is coupled between segments of the instrument and has a bend radius that is smaller than flexible arms having a similar cross section diameter. The actuating forces transmitted by the U-turn mechanism are used to move distal components of the instrument, such as an end effector and a wrist mechanism.

Side looking minimally invasive surgery instrument assembly

A surgical instrument is inserted through a guide tube. The surgical instrument exits at an intermediate position of the guide tube and is oriented to be substantially parallel to the guide tube's longitudinal axis as it exits. A stereoscopic image capture component is on the guide tube between the intermediate position and the guide tube's distal end. The image capture component's field of view is generally perpendicular to the guide tube's longitudinal axis. The guide tube is jointed to allow the image capture component to be moved. The surgical instruments and the guide tube are telemanipulatively controlled.

Surgical system entry guide

An entry guide tube and cannula assembly, a surgical system including the assembly, and a method of surgical instrument insertion are provided. In one embodiment, the assembly includes a cannula having a proximal portion that operably couples to an accessory clamp of a manipulator arm, and a distal tubular member coupled to the proximal portion, the tubular member having an opening for passage of at least one instrument shaft. The assembly also includes an entry guide tube rotatably coupled to the proximal portion of the cannula, the entry guide tube including a plurality of channels for passage of a plurality of instrument shafts, wherein the entry guide tube is rotatably driven relative to the proximal portion of the cannula by rotation of at least one instrument shaft about a longitudinal axis of the entry guide tube.

Force transmission for robotic surgical instrument

A force transmission transmits a force received by an input gimbal plate having two degrees of freedom to an output gimbal plate. The input gimbal plate is coupled to a first end of least three lever arms supported by a pivot. The output gimbal plate is coupled to a second end of the lever arms. The output gimbal plate may be coupled to the lever arms by flexible cables. The cables may be substantially contained within a tube. The output gimbal plate may be substantially smaller than the input gimbal plate. The force transmission may include a secondary output gimbal plate coupled to secondary levers that are coupled to the lever arms. The secondary levers may be third class levers. The secondary output gimbal plate may move proportionately to movement of the output gimbal plate. The force transmission may control a surgical end effector in a robotic surgical instrument.

Device for endoscopic advancement through the small intestine

Master having redundant degrees of freedom

The invention provides an input device for robotic surgical techniques and other applications. The input device has a handle supported by a linkage having joints with a redundant degree of freedom, with the joints being movable with at least one more degree of freedom than the handle. At least one joint of the linkage is actively driven to prevent the linkage from approaching singularities of the joint system, motion limits of the joints, or the like, and also to drive the linkage toward a freely articulatable configuration. In one embodiment, a robotic master controller includes an arm assembly supporting a gimbal having such a redundant linkage, with the arm primarily positioning the gimbal in a three dimensional controller workspace and the gimbal coupling the arm to the handle with four rotational degrees of freedom. One or more additional degrees of freedom may also be provided for actuation of the handle.

Bayonet - type finish for a container

This finish (12) has bayonet provisions (34), each including circumferential catch portions (38), a first stop rib (36) and a detent ridge (46) downward from the distal end (40) of the catch portion. This finish also has ramp provisions (50), each including a second stop rib (52) and a sloping wedge portion (56) extending down from top of the stop rib and having a surface sloping at 40° from an imaginary circumferential line at the wedge portion. The stops, detent ridges and wedge surfaces all provide tactile notification to user as to the location of lugs (20) on a cooperant cap on the finish.

Minimally invasive surgical system

The distal end of a surgical instrument is movable in all six Cartesian degrees of freedom independently of other components of a telemanipulated surgical system. The surgical instrument extends through a guide tube. The distal end is moved by actuators that are telemanipulatively controlled.

Surgical system entry guide

An entry guide tube and cannula assembly, a surgical system including the assembly, and a method of surgical instrument insertion are provided. In one embodiment, the assembly includes a cannula having a proximal portion that operably couples to an accessory clamp of a manipulator arm, and a distal tubular member coupled to the proximal portion, the tubular member having an opening for passage of at least one instrument shaft. The assembly also includes an entry guide tube rotatably coupled to the proximal portion of the cannula, the entry guide tube including a plurality of channels for passage of a plurality of instrument shafts, wherein the entry guide tube is rotatably driven relative to the proximal portion of the cannula by rotation of at least one instrument shaft about a longitudinal axis of the entry guide tube.

Surgical system entry guide

An entry guide tube and cannula assembly, a surgical system including the assembly, and a method of surgical instrument insertion are provided. In one embodiment, the assembly includes a cannula having a proximal portion that operably couples to an accessory clamp of a manipulator arm, and a distal tubular member coupled to the proximal portion, the tubular member having an opening for passage of at least one instrument shaft. The assembly also includes an entry guide tube rotatably coupled to the proximal portion of the cannula, the entry guide tube including a plurality of channels for passage of a plurality of instrument shafts, wherein the entry guide tube is rotatably driven relative to the proximal portion of the cannula by rotation of at least one instrument shaft about a longitudinal axis of the entry guide tube.

Minimally invasive surgical system

The distal end of a surgical instrument is movable in all six Cartesian degrees of freedom independently of other components of a telemanipulated surgical system. The surgical instrument extends through a guide tube. The distal end is moved by actuators that are telemanipulatively controlled.

Waterproofing starch adhesive containing urea-formaldehyde condensate and trimetaphosphate salt and process of making same

Compositions for removal of wrinkles in fabrics

Compositions for removal of wrinkles in textile fabrics particularly including wool and silk, a primary active ingredient of the compositions being a cationic surfactant or surfactants, preferably based on low molecular weight vegetable oils. A preferred solvent/carrier is selected to be high purity deionized water which exhibits synergism with the cationic surfactant and with relatively low concentrations of alcohols in the compositions, the anti-wrinkling action of the compositions occurring especially with exceptionally low concentrations of the cationic surfactant or surfactants. The low concentrations of the cationic surfactants coupled with the low molecular weights of said surfactants reduce residues remaining on the textile fabrics and enable the compositions to demonstrate increased effectiveness on ordinary textile fabrics and extraordinary effectiveness and accept-ability on textile fabrics formed of natural fibers such as wool and silk. The compositions of the invention can be applied to textile fabrics as a fine mist or by other methods of application and can particularly be used in a home environment without hazard to the fabric or the health and safety of a user.

Scanning system and method for scanning a plurality of samples

A system for detecting fluorescence emitted from a plurality of samples in a sample tray is provided. The system generally includes a plurality of lenses (12) positioned in a linear arrangement, a linear actuator configured to translate the plurality of lenses, an excitation light source (16), an excitation light direction mechanism (18) for directing the excitation light to a single lens of the plurality of lenses at a time so that a single sample holder aligned with the lens is illuminated at a time, and an optical detection system (20) for analyzing light from the sample holders. In certain embodiments, the optical detection system includes a light dispersing element (80), and a lens element (82) to direct the light onto a light detection device (90). A method of scanning a sample tray having a plurality of samples positioned in sample holders to detect fluorescence is also provided.

Non-corrosive cleaning composition for removing plasma etching residues

PROCESS FOR THE PREPARATION OF ALUMINUM DISC MEMORIES HAVING A SMOOTH METALLIC FINISH.

Procédé de production de revêtements métalliques extrêmement lisses sur des substrats d'aluminium zingués en utilisant une technique spéciale de double zinguage et/ou un bain de métallisation non galvanique spécialement formulé employant un procédé de métallisation original.

Coaxial helicopter with one cyclic pitch control rotor

A coaxial helicopter (10), comprising a first rotor (14 or 15) carried by a first shaft (16 or 18) and a second rotor (14 or 15) carried by a second shaft (16 or 18); wherein one of the first and second rotors has cyclic pitch control and the other rotor does not have cyclic pitch control, at least pitch and roll control being implemented by cyclic blade pitch control of only one rotor of the coaxial rotor set (12). Provisions for yaw control can include differential collective control of the first and second rotors (14, 15), providing yaw paddles (34, 36) and/or a tail rotor (420), ducted fan (402), or an air jet (410) configured for yawning the coaxial helicopter.

Fill spout for a drainage device

A fill spout (22) for a drainage device (10) is disclosed that permits the user to supply water directly to a water seal chamber (16) of the drainage device (10) for establishing a water seal (80) therein. The fill spout (22) comprises a funnel (42) having lateral sides (44,46) for facilitating the entry of the water into the drainage device (10), a depending lip (60) extending from the fill spout (22) for preventing any run off or spillage, and a tab (56) having an arcuate-shaped rest (62) which permits the user to open and close the fill spout (22). In use, the user pulls the tab (56) which opens the fill spout (22) and places a water-filled container (82) against the rest (62). The user then pours a predetermined amount of water seal (80) through the funnel (42) and directly into the water seal chamber (16).

Optical instrument including excitation source

An instrument includes a plurality of spaced-apart reaction regions (40) and a light source (10) comprising more than one individual light source. The light source is capable of illuminating more than one of the plurality of reaction regions with excitation beams (25). The individual light sources are arranged in groups and different groups of individual light sources are configured to emit different excitation frequencies. Each group of individual light sources is configured to provide excitation beams that illuminate one or more of the plurality of reaction regions simultaneously.

PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES

This application relates to compounds of the general Formula I and salts thereof, wherein X, R 1A , R 1B , R 2 , R 3 , R 4 , and R 5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.

Wire/disk board-to-board interconnect device

An apparatus and method for creating a stack assembly of print circuit boards and for providing electrical interconnection between the individual through-plated hole pads of the circuit boards is described. The preferred embodiment of the present invention is a device comprised of two parts: a slotted disk and a wire. The slotted disk is attached to the surface of the printed circuit board so as to cover a hole pad and form an electrical connection therewith. The covered holes of the printed circuit board are axially aligned between circuit boards and an electrically conducting wire is inserted through the slotted disks on the circuit boards to form an electrical connection therewith.

Redundant axis and degree of freedom for hardware-constrained remote center robotic manipulator

A remote center manipulator for use in minimally invasive robotic surgery includes a base link held stationary relative to a patient, an instrument holder, and a linkage coupling the instrument holder to the base link. First and second links of the linkage are coupled to limit motion of the second link to rotation about a first axis intersecting a remote center of manipulation. A parallelogram linkage portion of the linkage pitches the instrument holder around a second axis that intersects the remote center of manipulation. The second axis is not coincident with the first axis. Third and fourth links of the linkage are coupled to limit motion of the fourth link to rotation about a third axis intersecting the remote center of manipulation. The third axis is not coincident with either of the first and second axes. Various combinations of hardware-constrained remote center of motion robotic manipulators with redundant mechanical degrees of freedom are disclosed.

Method of debossing from character and indicia-forming pigmented tape

A method of debossing character and indicia-forming pigmented tape onto a report or book cover workpiece positioned under a print engine having a character finger daisy wheel forcer and a logo die or other indicia die forcer is described. Steps of inserting a print wheel and a first tape cartridge into the engine, heating a character-containing portion of a character finger, forcing and printing a desired character in a character debossment operation are included. In another operation, the steps of removing the daisy wheel and the first tape cartridge, inserting an indicia-forming debossment die and a second tape cartridge, heating the die and forcing and thermally printing desired indicia on the workpiece, is set forth. In another aspect of the method, the steps of holding the tape on reels in the cartridges, striking the tape to deboss the pigmented media, stripping a struck portion of the tape from the workpiece and then advancing a tape take-up reel are set forth. In another embodiment, the steps of determining residual heat in a character portion or die and varying the dwell time of subsequent strikings of the workpiece accordingly, are included.

Clothes wringer

Ultralight coaxial rotor aircraft

An ultralight coaxial dual rotor helicopter (10) having a substantially L shaped frame (12). Attached to the back of the frame is a vertical shaft engine, and a pair of yaw paddles (30, 32) for controlling yaw of the craft. The drive shaft (22) connects to a belt drive at the top of the frame, which transmits the engine power to a transmission and coaxial drive gear for driving the rotors (16). Crank actuators are provided for tilting the rotor axis to control the pitch and roll of the craft. A pilot seat (34) and ballast tank are attached to the front of the frame. The ballast tank (48) may be filled with a volume of water to balance the craft for the weight of the pilot. The fuel tank (56) is located behind the pilot seat (34) on the centerline of the helicopter, such that as fuel is used and the weight of fuel in the tank changes, the balance of the craft will not be affected. A simplified electronic control system controls all functions of the helicopter in response to pilot input.

Reinforced concrete

CUTTING TOOL HOLDER ASSEMBLY, PARTICULARLY FOR CUTTER PIC

Flashback chamber visual enhancement

Featured is a medical infusion device for vascular access with enhanced flashback visualization that includes a hub assembly having a flashback chamber. The hub assembly includes a proximal portion, a distal portion and a substantially transparent window section intermediate the proximal portion and distal portion. A needle is coupled to the flashback chamber so that fluid flows through the lumen of the needle into the flashback chamber after the needle is inserted into a blood vessel. A contrasting member is disposed on at least a portion of the hub assembly, so that when blood enters the flashback chamber, the contrasting member provides a high-contrast background when viewed through the window section.

Preparation and Uses of 1,2,4-Triazolo [1,5a] Pyridine Derivatives

This application relates to compounds of the general Formula I and salts thereof, wherein X, R 1A , R 1B , R 2 , R 3 , R 4 , and R 5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.

Vinyl resins plasticized with polycarbonate polymers

Selected aminoester derivatives of trichloroacetonitrile

Disclosed are selected aminoester derivatives of the formula: ##STR1## wherein R is hydrogen, lower alkyl having 1 to 4 carbon atoms, phenyl, benzyl, and substituted phenyl and benzyl in which said phenyl ring substituents are selected from lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms, halo, hydroxy, nitro, amino and mixtures thereof; wherein R' is lower alkyl having 1 to 4 carbon atoms; and n is 1 or 2. Examples of these compounds have shown bactericidal and herbicidal activity.

Flocculation by starch ethers

Photoresist composition containing orthoquinone or naphthoquinone diazide and polyamic acid condensation product

Abstract of the Disclosure A positive working, thermally stable photoresist, comprising a light-sensitive orthoquinone diazide or naphtho-quinone diazide and a polyamic acid condensation product of an aromatic dianhydride and an aromatic di-primary amine, and a support carrying a layer of said photoresist. After exposure, the image is developed in the layer with an alkaline aqueous developer and is unaffected by heating to 500°C, thus allowing the use of the photoresist layer for plasma and sputter-etching as well as ion implantation.

Particle stabilized emulsions for extraction of hydrocarbons from oil sands and oil shale

Particle-stabilized emulsions, of the sort which can utilize liquid carbon dioxide and/or supercritical carbon dioxide as a continuous or a dispersed phase, for hydrocarbon extraction.

Fill spout for a drainage device

A fill spout (22) for a drainage device (10) is disclosed that permits the user to supply water directly to a water seal chamber (16) of the drainage device (10) for establishing a water seal (80) therein. The fill spout (22) comprises a funnel (42) having lateral sides (44,46) for facilitating the entry of the water into the drainage device (10), a depending lip (60) extending from the fill spout (22) for preventing any run off or spillage, and a tab (56) having an arcuate-shaped rest (62) which permits the user to open and close the fill spout (22). In use, the user pulls the tab (56) which opens the fill spout (22) and places a water-filled container (82) against the rest (62). The user then pours a predetermined amount of water seal (80) through the funnel (42) and directly into the water seal chamber (16).

Preparation of propionamide ethers of starch

Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives

This application relates to compounds of the general Formula I and salts thereof, wherein X, R

Miner cutting bit holding apparatus

ABSTRACT OF THE DISCLOSURE Apparatus for supporting a cutting bit having an extended shank on a rotatable cutting drum is provided. The support apparatus includes a bit holder having an upper body portion and a shank portion and a generally rectangular mounting base having rear, side and front members. The upper body of the bit holder includes a bore for receiving the cutting bit shank and upper rear abutment surfaces perpendicular to the bit axis. The shank of the bit holder has a lower rear abutment surface having horizontal and vertical areas and a threaded bore which extends into the shank intermediate the upper and lower abutment surfaces. The rear portion of the mounting base includes upper abutment surfaces perpendicular to the bit axis and a lower abutment surface having horizontal and vertical areas. A draw bolt passes through the rear portion of the mounting base and serves to draw the upper and lower abutment surfaces of the bit holder and mounting base, respectively, into engagement.

Rotorcraft

Adhesive applicator for carton sealing machines

Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength

An apparatus for differentiating multiple detectable signals comprises a light source (16) that can emit respective excitation light wavelengths toward a sample in a sample retaining region (10).

Side looking minimally invasive surgery instrument assembly

A surgical instrument is inserted through a guide tube. The surgical instrument exits at an intermediate position of the guide tube and is oriented to be substantially parallel to the guide tube's longitudinal axis as it exits. A stereoscopic image capture component is on the guide tube between the intermediate position and the guide tube's distal end. The image capture component's field of view is generally perpendicular to the guide tube's longitudinal axis. The guide tube is jointed to allow the image capture component to be moved. The surgical instruments and the guide tube are telemanipulatively controlled.

Process for the preparation of secondary alkyl sulfate-containing surfactant compositions

This invention relates to a process for preparing secondary alkyl sulfate-containing surface active compositions substantially free of unreacted organic matter and water, which process comprises: a) sulfating a mixture of a detergent range olefin having from about 8 to about 22 carbon atoms and a detergent range alcohol having from about 8 to about 22 carbon atoms with a sulfating agent, b) neutralizing the product of step a) with a base dispersed in a nonionic surfactant having a boiling point higher than that of said detergent range olefin and its corresponding secondary alcohol, c) saponifying the product of step b), d) passing the product of step c) through a thin film evaporator to evaporate unreacted organic matter from said product and recovering said product.

Bayonet - type finish for a container

3-Lower alkoxy-6-trichloromethylpyridazines and their use as fungicides

3-halo- and 3-lower alkoxy-6-trichloromethylpyridazine compounds are disclosed as fungicides.

Flashback chamber visual enhancement

Featured is a medical infusion device for vascular access with enhanced flashback visualization that includes a hub assembly having a flashback chamber. The hub assembly includes a proximal portion, a distal portion and a substantially transparent window section intermediate the proximal portion and distal portion. A needle is coupled to the flashback chamber so that fluid flows through the lumen of the needle into the flashback chamber after the needle is inserted into a blood vessel. A contrasting member is disposed on at least a portion of the hub assembly, so that when blood enters the flashback chamber, the contrasting member provides a high-contrast background when viewed through the window section.

Optical instrument includung excitation source

An optical instrument for illuminating two or more spaced-apart regions comprises (40) a light source (10) and a collimating lens (20) to form bundles of collimated excitation beams.

Metallized connector block

A completely shielded metallized connector block for use in multiple circuit modules of an electronic device. Electrical communication between the circuit boards is effected by an array of metallic pins which run through the blocks. The metallization on the nonconductive blocks can be held at ground or at a constant potential to increase the shielding between pins as well as maintaining voltage and ground planes at constant levels throughout the modules. The metallization is insulated from the pins and circuit boards by nonconductive bushings inserted in holes in the blocks. In one embodiment, the metallization consists of copper and solder plating and the blocks are constructed of liquid crystal polymer.

Azaquinazoline inhibitors of atypical protein kinase c

The present invention provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders.

Redundant axis and degree of freedom for hardware-constrained remote center robotic manipulator

A remote center manipulator for use in minimally invasive robotic surgery includes a base link held stationary relative to a patient, an instrument holder, and a linkage coupling the instrument holder to the base link. First and second links of the linkage are coupled to limit motion of the second link to rotation about a first axis intersecting a remote center of manipulation. A parallelogram linkage portion of the linkage pitches the instrument holder around a second axis that intersects the remote center of manipulation. The second axis is not coincident with the first axis. Third and fourth links of the linkage are coupled to limit motion of the fourth link to rotation about a third axis intersecting the remote center of manipulation. The third axis is not coincident with either of the first and second axes. Various combinations of hardware-constrained remote center of motion robotic manipulators with redundant mechanical degrees of freedom are disclosed.

Pyrrolotriazines as alk inhibitors

This application provides compounds of the general formula (I) and/or a salt thereof, where X, R1 and R2 are as defined herein. Compositions and therapeutic uses are also described.

CLOSURE INDICATING FORCING, FOR A CONTAINER AND METHOD TO APPLY TO THE CONTAINER

La presente invención se refiere a cierre que indica forzamiento o manipulación indebida de un recipiente, caracterizado porque incluye una tapa de plástico moldeada en una pieza adaptada para fijarse a una porción de cuello de un recipiente, la tapa tiene interacopladores adaptados para interacoplarse en una banda indicadora de violaciones que depende de una porción de faldón a lo largo de una línea debilitada, la porción de cuello del recipiente tiene una porción roscada que se proyecta hacia afuera, la tapa de plástico tiene una porción de pared superior, una porción de faldón de forma general cilíndrica que depende de la porción de pared superior, una porción roscada que se proyecta hacia adentro y una banda indicadora de forzamiento o manipulación indebida que depende de la porción de faldón, la banda incluye una porción de banda anular y una pluralidad de proyecciones similares a rebordes, circunferencialmente separadas, que se extienden integralmente hacia adentro de la porción de banda, las proyecciones se disponen en varias hileras y las proyecciones en una hilera se desvían de las proyecciones en la hilera adyacente, proyecciones sucesivas similares a rebordes en la pluralidad de proyecciones similares a rebordes están dispuestas desde una hasta otra a lo largo de la línea de paso que está inclinada por un ángulo desde una línea radial horizontal; cada una de las proyecciones incluyen una superficie adaptada para corresponder con la porción roscada del cuello del recipiente permitiendo el tapado, adaptándose en la superficie para acoplar con una superficie de reborde en el recipiente cuando el cierre se separa, asegurando las proyecciones en la pluralidad de proyecciones similares a rebordes para sujetar la banda con el recipiente mientras se corta del cierre a lo largo de la línea debilitada durante la separación.