ИНТЕГРИРОВАННЫЙ ИЗМЕРИТЕЛЬ ДЛЯ ТЕСТИРОВАНИЯ ОБРАЗЦА

... 1. Интегрированный тестирующий образец измеритель, содержащий один модульный корпус, включающий в себя средство прокола, набор элементов привода для ввода в действие средства прокола между выдвинутым положением и отведенным назад положением, картридж с тестирующими полосками, содержащий множество тестирующих полосок, причем каждая полоска имеет принимающую образец область, датчик для анализа образца жидкости, принятого на тестирующую полоску, и устройство подачи тестирующей полоски для выдвижения тестирующих полосок отдельно из картриджа в принимающее образец положение, в котором тестирующая полоска соединена с датчиком, причем измеритель выполнен так, что при использовании, когда он располагается в первом положении на коже пользователя и активирован, средство прокола выполнено с возможностью движения в его выдвинутое положение и отвода назад для образования прокола в коже пользователя, а тестирующая полоска способна выдвигаться из картриджа в принимающее образец положение. 2. Измеритель ...

ИЗМЕРИТЕЛЬНОЕ УСТРОЙСТВО И СПОСОБ ИЗМЕРЕНИЯ

... 1. Измерительное устройство, которое измеряет количественную информацию о веществе, содержащемся, по меньшей мере, в одном носителе, выбранном из подкожной интерстициальной жидкости и крови, содержащее:секцию датчика, имеющую датчик, выводящий сигнал в соответствии с количественной информацией, и вычислительную секцию, которая принимает сигнал, выведенный датчиком, и выполняет вычислительную обработку на основе сигнала,причем датчик формируется так, что часть его может быть размещена под кожей, ивычислительная секция размещается так, чтобы быть изолированной от секции датчика.2. Измерительное устройство по п.1, в котором вычислительная секция электрически соединяется с секцией датчика через провод.3. Измерительное устройство по п.1, в котором вычислительная секция связывается с секцией датчика по беспроводной связи.4. Измерительное устройство по п.2, в котором соединяющая структура, которая разрешает выбор между соединенным состоянием и разъединенным состоянием, предусмотрена в проводе.5 ...

Устройство для анализа крови

Glukose-Elektrode und Verfahren zur Bestimmung von Glukose.

Sensoranordnung zur Messung von Substanzen in Flüssigkeiten.

VORRICHTUNG ZUM ERFASSEN PHYSIOLOGISCHER DRUECKE

IMPLANTIERBARER GLUKOSE-SENSOR

Apparatus for administering fluid to a medical tube

Analyte sensor antimicrobial configurations and adhesives

An analyte sensor and methods and systems related thereto, where at least one or more of a lower portion of a sensor tail substrate, at least one electrode, a sensing element, a membrane, and an optional non-electrochemical functional layer comprise an antimicrobial quality. Asymmetric, double-sided adhesive binders suitable for adhering the analyte sensor to a skin surface comprising a non-woven scrim, a first pressure-sensitive adhesive layer, a second pressure-sensitive adhesive layer. Overbandages comprising a vapor-permeable backing, an aperture to circumferentially surround a sensor housing, a contact adhesive layer, first and second peelable release liners, and a third peelable release liner disposed upon an anchoring adhesive strip of the contact adhesive layer.

DEVICE AND PROCEDURE FOR THE DETERMINATION OF THE ANALYTPEGELS

PROCEDURE FOR THE PRODUCTION OF A SUBSTRATE

DEVICE FOR COLLECTING LIQUIDS WITH INTEGRATED LANZETTE AND REACTION RANGE

PROCEDURE AND DEVICE FOR THE MEASUREMENT OF BLOOD GAS PARAMETERS

PROCEDURE FOR THE INCREASE OF THE FUNCTION LIFE SPAN OF A IMPLANTIERBAREN FEELER

DEVICE TO THE WITHDRAWAL OF BODY FLUIDS AND TO ANALYTENÜBERWACHUNG

ON A SUBSCRIPTION BASING BIO SENSOR MONITORING PROCEDURE

TONOMETRI CATHETER DEVICE AND PROCEDURE WITH REMOTE SENSOR

VORRICHTUNG ZUR BESTIMMUNG DER KONZENTRATION ZUMINDEST EINER MEDIZINISCHEN SUBSTANZ IN LEBENDEN ORGANISMEN

APPLICABLE GASES OF ABSTENTIONS BIO SENSOR AND PROCEDURE FOR THE DETERMINATION OF A ANALYTE SUCH AS GLUCOSE.

ELECTRO-CHEMICAL SENSOR CELL TO THE CONTINUOUS SHORT TERM USE IN FABRICS AND BLOOD.

DEVICE FOR THE DETERMINATION OF INTERESTING PARAMETERS IN LIVING ORGANISMS.

DEVICE FOR THE IMPLANTATION OF SENSORS

SMALL-VOLUMED SENSOR TO IN-VITRO REGULATION

DEVICE FOR IMPROVEMENT THE TRANSDERMALEN ADMINISTRATION OF MEDICINES OR THE DECREASE OF BODY FLUIDS

DEVICE FOR IMPROVEMENT THE TRANSDERMALEN DECREASE OF BODY FLUIDS

BIO SENSOR DEVICE AND ASSOCIATED PROCEDURE FOR THE DETECTION OF KIND AND VOLUME OF A SAMPLE

PROCEDURE AND DEVICE FOR THE MEASUREMENT OF BLOOD GAS PARAMETERS

ON A SUBSCRIPTION BASING BIO SENSOR MONITOR AND - PROCEDURES

DEVICE FOR IMPROVEMENT THE TRANSDERMALEN ADMINISTRATION OF MEDICINES OR THE DECREASE OF BODY FLUIDS

PROCEDURE FOR THE PRODUCTION OF MINIATURIZED CHEMO AND BIO SENSOR ELEMENTS WITH ION-SELECTIVE DIAPHRAGM AS WELL AS OF CARRIERS FOR THESE ELEMENTS

DEVICE FOR THE TELEMETERING OF MEANS OF A PRINTING MEASURING CATHETER

DEVICE TO THE AUTOMATIC ONE DURCHF�HRUNG OF PERITONEALGLEICHGEWICHTSUNTERSUCHUNGEN

USE OF A ION-SELECTIVE POLYMER DIAPHRAGM FOR THE REGULATION OF HEPARIN

Physiological signal monitoring device with an electrostatic-discharge protective mechanism

PHYSIOLOGICAL SIGNAL MONITORING DEVICE WITH AN ELECTROSTATIC-DISCHARGE PROTECTIVE MECHANISM A physiological signal monitoring device includes 5 a base (1) and a transmitter (3). The base (1) is provided with a biosensor (2). The transmitter (3) is removably coupled to the base (1), and includes a casing (31) and an electrostatic-discharge protective unit (39) . The casing (31) has a socket (367) for the 10 biosensor (2) to be removably inserted thereinto. The electrostatic-discharge protective unit (39) is disposed to at least surround the periphery of the socket (367) to dispel static electricity when electrostatic discharge occurs. (Fig. 2) 'II 'IM ...

Methods and systems for improving the reliability of orthogonally redundant sensors

A method of calibrating an orthogonally redundant sensor device for determining the concentration of glucose in a body of a user, said sensor device including at least an electrochemical glucose sensor and an optical glucose sensor, the method comprising: receiving a first signal from the electrochemical glucose sensor; receiving a second signal from the optical glucose sensor; performing a respective integrity check on each of said first and second signals; determining whether the first signal can be calibrated, and whether the second signal can be calibrated, wherein said determination is made based on whether the first signal and the second signal pass or fail their respective integrity checks; if it is determined that the first signal can be calibrated, calibrating said first signal to generate an electrochemical sensor glucose (SG) value; if it is determined that the second signal can be calibrated, calibrating said second signal to generate an optical sensor glucose (SG) value; and ...

Method and apparatus for obtaining blood for diagnostic tests

Analytical device with prediction module and related methods

A minimally-invasive system and method for monitoring analyte levels

Electrochemical sensor having symmetrically distributed analyte sensitive areas

The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.

Drug elution for in vivo protection of bio-sensing analytes

A sensor ( ...

Methods and systems for improving the reliability of orthogonally redundant glucose sensors

Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain ...

CALIBRATION APPARATUS

Physiological signal monitoring device

A physiological signal monitoring device includes a base, a biosensor mounted to the base, a transmitter, and a sealing unit. The base is adapted to be mounted 5 to a skin surface of a host. The biosensor includes a mounting seat and a sensing member that is mounted to the mounting seat. The sensing member is adapted to be partially inserted underneath the skin surface of the host for measuring an analyte of the host and to send 10 a corresponding physiological signal. The transmitter is for receiving and transmitting the physiological signal, and has a bottom portion. The transmitter covers the base while the bottom portion faces the base. The sensing member is coupled to the transmitter. The 15 sealingunitis used to sealpaths throughwhichaliquid possibly penetrates into an interior of the physiological signal monitoring device so as to avoid damage of the device.

Percutaneous biological fluid sampling and analyte measurement devices and methods

Holter-type monitor system comprising an analyte sensor

An analyzing apparatus and method

Reusable analyte sensor site

Percutaneous biological fluid constituent sampling and measurement devices and methods

PERCUTANEOUS BIOLOGICAL FLUID SAMPLING AND ANALYTE MEASUREMENT DEVICES AND METHODS

A device for sampling a biological fluid and measuring at least one target constituent within the biological fluid. The device has at least one electrochemical cell having an inner electrode and an outer electrode in a concentrically-spaced relationship. In a preferred embodiment, the outer electrode has a cylindrical configuration having an open distal end and the inner electrode has an elongated configuration positioned co-axially within the outer electrode and a distal end configured to penetrate the skin. The spacing between the electrodes exerts a capillary force on biological fluid present at the open distal end of the outer electrode. A system is also provided which includes a control unit in electrical communication with the electrochemical cell for controlling the selection and measurement of the target constituent. Methods of sampling of biological fluids within the skin and measuring the sampled fluids are also provided, as well as kits comprising one or more of the inventive ...

BIOLOGICAL FLUID SAMPLING AND ANALYTE MEASUREMENT DEVICES AND METHODS

A device for sampling a biological fluid and measuring a target analyte within the biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and access biological fluid, a sampling means and a measuring means. The sampling means comprises a fluid transfer medium, such as a hydrophilic porous material, by which sampled biological fluid is transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode and, typically, a reagent material, where the electrochemical cell is configured so as to make an electrochemical measurement of a target analyte in accessed biological fluid present therein. Methods of sampling biological fluids within the skin and measuring the sampled fluids are also provided, as well as kits comprising one or more of the inventive devices.

DEVICES FOR PHYSIOLOGICAL FLUID SAMPLING AND METHODS OF USING THE SAME

Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable firm the silt, where the order of the above-described steps may be altered. The subject devices include at least one silo flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.c., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sifts in the fingers, arms, legs, earlobes, heels, feet, nose: and toes. Also provided ...

COMPLETE GLUCOSE MONITORING SYSTEM WITH AN IMPLANTABLE, TELEMETERED SENSOR MODULE

A COMPLETE GLUCOSE MONITORING SYSTEM WITH AN IMPLANTABLE, TELEMETERED SENSOR MODULE An electrochemical system includes a sensor module suitable for implantation in the body to monitor glucose and oxygen levels therein. The module has two oxygen sensors situated in an oxygen-permeable housing, arranged in a tandem relationship, and recessed in the housing, one sensor being unaltered and the other contacting glucose oxidase allowing for differential measurement of oxygen content in bodily fluids or tissues indicative of glucose levels. The module includes a communication capability for transmitting measurement information to an external recording device outside the body.

OXYGEN SENSOR

Oxygen Sensor An oxygen sensor and method of monitoring the oxygen content of blood or other body fluids are provided, which oxygen sensor and method achieve monitoring of enhanced accuracy that is not substantially effected by the presence of an anaesthetic within the fluid being monitored. The electrolyte used in connection with this invention includes a preferential adsorption component that exhibits adsorption to the cathode of the sensor which is in preference to adsorption of the anaesthetic to the cathode of the sensor.

INSTRUMENT FOR MEASURING LIVING BODY COMPONENTS

INSTRUMENT FOR MEASURING LIVING BODY COMPONENTS Disclose is an instrument for measuring living body components, which has (i) a fine tube having at one end thereof a connection portion to be connected to an indwelling needle or indwelling catheter and an infusion portion, from which at least a blood anticoagulant solution can be infused, (ii) a fine linear sensor for measuring living body components, extended from the inferior of the fine tube to the outside through the connection portion, and (iii) a mechanism for introducing blood at least into the interior of a fine tube portion of the indwelling needle ox catheter intermittently or periodically when the indwelling needle or catheter is connected to the fine tube and kept in the blood vessel and then discharging blood into the blood vessel. A sensing portion of the sensor is located within the fine tube portion of the indwelling needle or catheter when the indwelling needle or catheter is connected to the connection portion of the fine ...

ION SELECTIVE ELECTRODES

ION SELECTIVE ELECTRODES of the Invention An ion selective electrode capable of production in miniaturized form suitable for in vivo monitoring is produced by coating a metal-metal salt half cell 48 with a layer 40 of hydrophilic material containing electrolyte with an overlayer 42 of an ion selective membrane. The coatings may be applied by a dipping and drying process. Stability is enhanced by addition of silver black 46 and platinum black 44 to the half cell and those materials may be added as layers in a similar dip and dry process. A companion reference electrode half cell is made of the same materials that are used in making the "half cell" portion of the selective electrode, except that the reference half cell is coated with a protein layer. Special packaging and a special procedure facilitate calibration.

PO2/PCO2 SENSOR

This invention relates to an electrochemical-sensor system for the simultaneous and continuous measurement of the partial pressure of oxygen PO2 and carbon dioxide partial pressure PCO2 in fluids. The electrochemical sensor of the present invention is particularly useful for intra-arterial measuring PCO2 and PO2 in blood and is readily adapted to transcutaneous measurement of these blood gases by the addition of a heating element and minor configurational changes.

LACTATE SENSORS AND ASSOCIATED METHODS

A lactate-responsive enzyme may form the basis for lactate detection and quantification using an electrochemical analyte sensor. Various features may be incorporated within an analyte sensor containing a lactate-responsive enzyme, particularly lactate oxidase, to improve sensitivity and response stability of the analyte sensor. Such analyte sensors may comprise: a working electrode having an active area disposed thereon, and a mass transport limiting membrane overcoating at least the active area upon the working electrode. The active area comprises at least a polymer, an albumin, and a lactate-responsive enzyme that is covalently bonded to the polymer. The mass transport limiting membrane may comprise at least a crosslinked polyvinylpyridine homopolymer or copolymer. The analyte sensors may determine a lactate concentration in a biological fluid, particularly in vivo, which may be correlated to various physiological conditions.

SYSTEM FOR ANALYZING A PATIENT USING A TRANSCUTANEOUS SENSOR

The invention relates to a system for analyzing a patient using a transcutaneous sensor, having a base unit for attaching to the patient, an injector, releasably connectable to the base unit, for the transcutaneous insertion of the sensor into the patient, and a detection unit, releasably connectable to the base unit, for generating measurement data by the sensor. The invention is characterized in that the base unit has a holding device which is configured to cooperate with the injector and detection unit such that, in a detection configuration with the detection unit arranged on the base unit, a contact pressure is applied to the sensor by the holding device for frictional fixing, and in an injection configuration with the injector arranged on the base unit, a lower contact pressure than in the detection configuration is applied to the sensor by the holding device.

METHOD AND DEVICE FOR DETECTION OF BIOAVAILABLE DRUG CONCENTRATION IN A FLUID SAMPLE

The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

ION SELECTIVE ELECTRODES

HOLTER-TYPE MONITOR SYSTEM COMPRISING AN ANALYTE SENSOR

A Holter-type monitor system includes a remotely located data receiving device, an analyte sensor for producing signal indicative of a characteristic of a user, and a Holter-type recording device. The Holter- type recording device includes a housing, a sensor connector, a processor, and a data port. The sensor connector receives the produced signals from the analyte sensor. The processor is coupled to the sensor connector and stores the signals from the analyte sensor for delivery to the remotely located data receiving device. The recording device is coupled to the processor for downloading the stored signals to the remotely located data receiving device. The data receiving device may be a characteristic monitor, a data receiver that provides data to another device, an RF programmer, a medication delivery device (such as an infusion pump), or the like.

BLOOD SENSOR AND BLOOD EXAMINING INSTRUMENT INCLUDING SAME

A blood sensor (20a) comprises a substrate (21); a spacer (22) attached t o the top of the substrate (21); a cover (23) attached to the top of the spa cer (22); a blood reservoir portion (24) defined by a substrate hole (21a) f ormed in the substrate (21), a part of a spacer hole (22a) formed in the spa cer (22) and connected to the substrate hole (21a), and a cover hole (23a) f ormed in the cover (23) and connected to the spacer hole (22a); a supply pas sage (25) defined by another part of the spacer hole (22a) and communicating with the blood reservoir portion (24); and detection electrodes formed in t he supply passage (25). The cover (23) projects from the supply passage (25) toward the inside of the blood reservoir portion (24) farther than the subs trate (21) and the spacer (22).

METHODS OF USING INFORMATION FROM RECOVERY PULSES IN ELECTROCHEMICAL ANALYTE MEASUREMENTS AS WELL AS DEVICES, APPARATUSES AND SYSTEMS INCORPORATING THE SAME

Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods allow one to correct and/or compensate for confounding variables such as temperature before providing an analyte concentration. The measurement methods use response information from a test sequence having at least one DC block, where the DC block includes at least one excitation pulse and at least one recovery pulse, and where a closed circuit condition of an electrode system is maintained during the at least one recovery pulse. Information encoded in the at least one recovery pulse is used to correct/compensate for temperature effects on the analyte concentration. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods.

PHYSIOLOGICAL MONITORING SYSTEM COMMUNICATING WITH AT LEAST ONE SOCIAL NETWORK

A physiological measurement system includes a biosensor providing a signal for a fluid sample. A processor determines a physiological parameter in the form of an analyte concentration using the signal from the biosensor. A network interface conveys data between the processor and a social network. The processor can transmit a query for analyte- data-request records to the social network, receive an indication of an analyte-data-request record from the social network, and transmit the determined analyte data or physiologic data to the social network in response to the indication. The processor can alternatively retrieve user credentials from a storage device, transmit the credentials and the analyte data to the social network, retrieve from the social network different-user response data corresponding to the transmission, and present an indication of the response data. Methods for processing analyte or physiologic data are also described. Various methods include transmitting credentials and ...

METHODS AND SYSTEMS FOR IMPROVING THE RELIABILITY OF ORTHOGONALLY REDUNDANT SENSORS

Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain ...

METHOD OF AND SYSTEM FOR STABILIZATION OF SENSORS

A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabiltzation circuitry cases a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic - cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulator voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

METHOD AND APPARATUS FOR CONTINUOUS ANALYTE MONITORING

Embodiments of the invention provide analyte sensors and sensor systems such as amperometric glucose sensors used in the management of diabetes as well: optimized methods for monitoring analytes using such sensors and sensor systems.

ANALYTE MONITORING DEVICE AND METHODS

Methods and devices for providing application specific integrated circuit architecture for a two electrode analyte sensor or a three electrode analyte sensor are provided. Systems and kits employing the same are also provided.

IN VIVO BIOSENSOR

Certain embodiments comprise an implantable probe for rapid measurement of multiple neurochemicals on the cellular scale in the brain. Rapid detection of multiple chemicals in vivo (animal or humans) may provide an improved understanding of acute changes in neurochemicals that occur over several seconds. The neurotransmitter chemical sensing platform may provide for continuous in vivo sensing in trials of psychoactive drugs in the laboratory animal market. The high spatial resolution of the probe may allow for chemical detection around small groups of neurons, which may help to isolate the endogenous activity of different neuron types due to disease states. Neurochemical detection may also be used to measure tissue response to exogenous stimuli, such as pharmacodynamics of drugs. The high temporal and spatial resolutions and multi-neurochemical sensing of the probe may allow for detailed studies on in vivo brain response to both endogenous and exogenous stimuli.

ACRYLIC COPOLYMER MEMBRANES FOR BIOSENSORS

... 2129626 9315651 PCTABS00024 Homogeneous membranes (20) are disclosed which are composed of acrylic copolymers and are capable of absorbing 10 % to 50 % of their dry weight of water. The copolymers include a hydrophilic component which comprises acrylic esters having a poly(ethylene oxide) substituent as part of the alcohol moiety. The copolymers further comprise methacrylate and/or acrylate monomer units. The membranes (20) are useful in the fabrication of biosensors, e.g., a glucose sensor (10), intended for in vivo use. Variations in the ratios of the monomeric components make possible the fabrication of membranes which have varying permeabilities.

ELECTROCHEMICAL SENSOR

A electrochemical sensor for the determination of the partial pressure of oxygen in a bloodstream comprising a cathode (20) and an anode (21) immersed in an electrolyte (17) contained in a chamber (23) defined by an oxygen gas permeable membrane (19) wherein the insulated portion of each of the conductors forming the cathode and the anode has an additional layer of insulation (24) applied over the original insulation.

METHOD AND APPARATUS FOR OBTAINING BLOOD FOR DIAGNOSTIC TESTS

Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and (b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises: (a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and (b) a vacuum pump. Preferably, the apparatus also includes a housing. In a further aspect of the invention, a pneumatic lancing assembly is provided. The pneumatic lancing assembly uses differential gas pressure to thrust a lancet into skin tissue. In another aspect of this invention ...

DEVICE TO THE SEQUENTIAL ONE OR GRADUAL ONE SUPERVISING THE PH VALUE OF THE PLASMA OF A PATIENT IN VIVO.

Self-powered analyte sensor and devices using the same

Medical fluid valve with real-time remote measuring function

Apparatus and method for biological humor sampling and measuring analyte

Multi -functional micropin array head electrode of implanted

Dispositif de protection contre les affections liées au sang, notamment thromboses, embolies, hémorragies, hémopathies et présence d'éléments anormaux dans le sang

Le dispositif, totalement implantable, comporte des moyens 1, 14, 15 de mesure automatique de paramètres biologiques du sang, notamment relatifs à la crase sanguine et/ou à l'hémodynamique, et/ou au myocarde et/ou aux artères, et/ou aux éléments présents dans le sang, des moyens d'observations implantés, des moyens de seuil pour une comparaison de la valeur mesuré de paramètre et des moyens délivrant automatiquement un traitement approprié, par exemple fibrinolytique. Ce dispositif comporte des moyens 4 d'acquisition et de traitement du rythme cardiaque.

APPARATUS Of CALIBRATION Of a DETECTOR

Pancréas artificiel

Le pancréas artificiel comprend une unité de prélèvement automatique et périodique d'échantillons de sang dans le corps d'un patient M, une unité de mesure de la glycémie de cet échantillon, une unité 8 d'injection d'insuline ou de glucose, et une unité U de calcul et de traitement informatique apte à déterminer la quantité d'insuline ou de glucose devant être administrée au patient en fonction du taux de glucose mesuré par l'unité de mesure, et à commander en conséquence l'unité d'injection 8; ce pancréas artificiel est caractérisé en ce que la mesure de la glycémie est effectuée par lecture de la couleur d'une bandelette réactive à la glycémie, l'unité de mesure comprenant à cet effet : a) un poste 3 de distribution de bandelettes; b) un poste 4 de dépôt d'une goutte de sang sur la bandelette; c) un poste 5 d'essuyage de la bandelette; d) un poste 6 de lecture optique de la couleur prise par la bandelette; e) un poste 7 d'évacuation de la bandelette; f) un dispositif de transport 1, 2 ...

SYSTEM FOR MONITORING BODY BY ELECTROPHORESIS

MINIMALLY INVASIVE DETECTING DEVICE

장착형 장치 내에 전자 장치를 캡슐화하는 시스템들 및 방법들

... 장착형 장치는 적어도 하나의 장착 표면을 규정하는 중합체 내에 내장된 생체 적합 구조를 포함한다. 생체 적합 구조는 생체 적합 재료의 제1 층에 의해 정해진 제1 측, 생체 적합 재료의 제2 층에 의해 정해진 제2 측, 전자 소자, 및 센서 전극들을 규정하는 도전성 패턴을 갖는다. 생체 적합 재료의 제2 층의 부분은 센서 전극들이 노출되는 제2 측 내에 적어도 하나의 개구를 만들도록 에칭에 의해 제거된다. 에칭은 제2 측 내의 적어도 하나의 개구에 연결된 제1 측 내의 적어도 하나의 개구를 만들도록 생체 적합 재료의 제1 층의 부분을 더 제거한다. 개구들의 이러한 배열로, 분석 물질은 생체 적합 구조의 제1 측 또는 제2 측으로부터 센서 전극들에 도달할 수 있다.

장착형 장치 내에 전자 장치를 캡슐화하는 시스템들 및 방법들

... 장착형 장치는 적어도 하나의 장착 표면을 규정하는 중합체 내에 내장된 생체 적합 구조를 포함한다. 생체 적합 구조는 생체 적합 재료의 제1 층에 의해 정해진 제1 측, 생체 적합 재료의 제2 층에 의해 정해진 제2 측, 전자 소자, 및 센서 전극들을 규정하는 도전성 패턴을 갖는다. 생체 적합 재료의 제2 층의 부분은 센서 전극들이 노출되는 제2 측 내에 적어도 하나의 개구를 만들도록 에칭에 의해 제거된다. 에칭은 제2 측 내의 적어도 하나의 개구에 연결된 제1 측 내의 적어도 하나의 개구를 만들도록 생체 적합 재료의 제1 층의 부분을 더 제거한다. 개구들의 이러한 배열로, 분석 물질은 생체 적합 구조의 제1 측 또는 제2 측으로부터 센서 전극들에 도달할 수 있다.

센서 이탈 방지부를 구비한 연속식 분석물 측정기

... 본 발명의 측정기는, 피부 내부로 침습되는 전기 화학적 센서; 상기 전기 화학적 센서가 연결되는 메인 기판과 상기 메인 기판이 수납되는 하우징을 포함하고, 상기 하우징은 피부에 부착되며 상기 메인 기판은 상기 전기 화학적 센서의 신호를 입출력하는 트랜스미터; 상기 전기 화학적 센서를 피부안으로 침투시키는 바늘; 상기 바늘이 피부를 관통하도록 제1 위치에서 제2 위치로 상기 트랜스미터 또는 바늘을 이동시키는 삽입기; 를 포함할 수 있다.

DEVICE FOR DETERMINING THE CONCENTRATION OF A LEAST ONE SUBSTANCE IN LIVING TISSUE

DISPOSITIVO PARA DETERMINAR LA CONCENTRACION DE UNA SUSTANCIA QUE SE ENCUENTRA EN UN TEJIDO ORGANICO, COMO LA CONCENTRACION DE GLUCOSA, Y COMPRENDIDO POR UNA AGUJA SUBCUTANEA INTRODUCIBLE EN EL TEJIDO, HABIENDO UNA UNIDAD DE BOMBEO Y SUCCION PARA HACER LLEGAR UN LIQUIDO DE PERFUSION Y EVACUARLO DESPUES DE EQUILIBRARLO CON EL TEJIDO, DETERMINANDOSE EL GRADO DE INTERACCION DEL LIQUIDO DE PERFUSION CON EL TEJIDO A BASE DE PARAMETROS INDICATIVOS ENDOGENOS O EXOGENOS DEL LIQUIDO, Y UNA UNIDAD ANALIZADORA PROVISTO DE MEDIDORES DE CONCENTRACION DE LA SUSTANCIA Y DE LOS PARAMETROS INDICATIVOS, LA AGUJA SUBCUTANEA ES DE UN SOLO CONDUCTO DE FLUJO REVERSIBLE ACOPLABLE A LA ENTRADA DE LA UNIDAD ANALIZADORA, PRESENTANDO LA AGUJA UNA ABERTURA AL LADO DE SU PUNTA EN LA FORMA DE UNA HENDIJA EN SU PARED, ESTANDO LA SALIDA DE LA UNIDAD ANALIZADORA CONECTADA A LA UNIDAD DE BOMBEO Y SUCCION A TRAVES DE UNA VALVULA DE VARIOS PASOS, ESTANDO LA UNIDAD DE BOMBEO Y SUCCION CONECTADA POR UNO DE LOS PASOS C ON LA ...

SYSTEM AND METHOD FOR DISEASE RISK ASSESSMENT AND TREATMENT

A biosensor assembly that measures multiple physical parameters is disclosed. The biosensor assembly includes a first implantable probe and a first skin contacting electrode. Wherein a first physiological parameter is measured between the first implantable probe and the first skin contactable electrode.

STEERABLE GUIDE CATHETER

A flexible guide tube having a deflectable distal end is disclosed with at least first and second tensioning lines coupled to a deflectable distal end of the flexible guide tube. The first tensioning line is configured to deflect the distal end of the flexible guide tube in a first direction and the second tensioning line is configured to deflect the distal end of the flexible guide tube in a second direction that is opposite the first direction. A handle is coupled to flexible tube, the handle having a medial portion with a longitudinal axis substantially parallel with at least a portion of the flexible guide tube, a first actuator disposed proximal the medial section, and a second actuator disposed distal the medial section.

ANALYTE SENSOR ANTIMICROBIAL CONFIGURATIONS AND ADHESIVES

An analyte sensor and methods and systems related thereto, where at least one or more of a lower portion of a sensor tail substrate, at least one electrode, a sensing element, a membrane, and an optional non-electrochemical functional layer comprise an antimicrobial quality. Asymmetric, double-sided adhesive binders suitable for adhering the analyte sensor to a skin surface comprising a non-woven scrim, a first pressure-sensitive adhesive layer, a second pressure-sensitive adhesive layer. Overbandages comprising a vapor-permeable backing, an aperture to circumferentially surround a sensor housing, a contact adhesive layer, first and second peelable release liners, and a third peelable release liner disposed upon an anchoring adhesive strip of the contact adhesive layer.

SENSOR INSERTION DEVICE AND SENSOR INSERTION METHOD

The present invention pertains to a sensor insertion device and a sensor insertion method. The sensor insertion device (10) has a travel mechanism (16) that inserts a detection unit (76) and an insertion needle (46) inside the body of a measurement subject. A grip member (86) configuring this travel mechanism (16) is blocked by a displacement prevention member (106) that prevents the grip member (86) from displacing to the body side of the measurement subject. If a signal processing device (12) (e.g., a transmitter) is attached to the device main body (14), the displacement prevention member (106) is pressed on to the signal processing device (12) and rotates, and, as a result, the blocking of the grip member (86) is released.

SENSOR, MEASUREMENT DEVICE, AND SENSOR MANUFACTURING METHOD

This sensor is characterized by comprising: a needle member that has a through-hole and defines a hollow part; and a long detection member that is positioned in the hollow part and that extends in the extending direction of the circumferential wall of the needle member, wherein the circumferential wall is provided with a protruding portion which protrudes inwardly in the radial direction of the needle member and which regulates movement of the detection member in the radial direction.

WEARABLE ELECTROCHEMICAL SENSOR AND METHOD

An electrochemical sensing system includes a working electrode and a reference electrode, which can at least partially be disposed in a housing. At least a portion of the working electrode includes rhodium metal. An electrical circuit is disposed in the housing and configured to be electronically coupled to the electrodes. The electrical circuit is operative to: (a) bias the working electrode at a voltage of less than about 0.4 V, and (b) measure a current corresponding to the concentration of the target analyte. A communications module is electrically coupled to the electrical circuit and configured to display a concentration of the target analyte, and/or communicate data between the electrical circuit and an external device. The electrodes are movable between a first configuration in which the electrodes are substantially disposed inside the housing, and a second configuration in which at least a portion of the electrodes is disposed outside the housing.

ELECTRODE SUBSTRATE, METHOD FOR MANUFACTURING SAME, AND BIOSENSOR USING ELECTRODE SUBSTRATE

This disclosure provides an electrode substrate comprising an insulating substrate having, on the front surface thereof, at least one area where a fine surface relief structure has been formed and a plurality of smooth areas separated by the fine surface relief structure, and a conductive thin film formed over the entirety of at least the one surface of the insulating substrate where the fine surface relief structure has been formed. This disclosure makes it possible to simultaneously form a conductive area and insulating area on an insulating substrate only by forming, in one step, a conductive thin film over the entirety of a single surface of the insulating substrate having a fine surface relief structure formed thereon.

LACTATE SENSORS AND ASSOCIATED METHODS

A lactate-responsive enzyme may form the basis for lactate detection and quantification using an electrochemical analyte sensor. Various features may be incorporated within an analyte sensor containing a lactate-responsive enzyme, particularly lactate oxidase, to improve sensitivity and response stability of the analyte sensor. Such analyte sensors may comprise: a working electrode having an active area disposed thereon, and a mass transport limiting membrane overcoating at least the active area upon the working electrode. The active area comprises at least a polymer, an albumin, and a lactate-responsive enzyme that is covalently bonded to the polymer. The mass transport limiting membrane may comprise at least a crosslinked polyvinylpyridine homopolymer or copolymer. The analyte sensors may determine a lactate concentration in a biological fluid, particularly in vivo, which may be correlated to various physiological conditions.

SENSING DEVICES BASED ON MICRONEEDLE ARRAYS FOR SENSING APPLICATIONS INCLUDING KETONE BODIES MONITORING

Disclosed is a wearable microneedle sensor platform for minimally-invasive, real-time monitoring of key biomarkers. In some aspects, a device includes a wearable epidermal sensor comprising an array of hollowed needles, each hollowed needle having a protruded needle structure including multiple layers forming a hollow interior, at least one hollowed needle including a working electrode to interact with one or more chemical or biological substances that come in contact with the protruded needle structure, at least one hollowed needle including a counter electrode to measure an electrical potential difference with the working electrode; and a wireless transmitter in communication with the sensor to generate output signals based on the electrical potential difference with the working electrode. The output signal represents β-hydroxybutyrate as a biomarker of ketone bodies.

BLOOD CONTACTING SENSOR

The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means (14). The assembly means has a sensor end (20), wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device (10). By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

DEVICE FOR ASSISTING TREATMENT OF DIABETES, METHOD FOR ASSISTING TREATMENT OF DIABETES AND PROGRAM FOR ASSISTING TREATMENT OF DIABETES

A device for assisting treatment of diabetes, wherein: a control unit (22) acquires, from a memory unit (23), preprandial blood glucose level data including multiple blood glucose levels measured before meals and postprandial blood glucose level data including multiple blood glucose levels measured after meals (S11, S13); calculates a mean preprandial level that is the mean of the preprandial blood glucose levels (S12); calculates a mean postprandial level that is the mean of the postprandial blood glucose levels (S14); calculates the mean blood glucose level that corresponds to the mean of the mean preprandial level and the mean postprandial level (S15); calculates an estimated HbA1c level using the mean blood glucose level (S16); and displays the estimated HbA1c level thus calculated on a display (10) (S17).