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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 27914. Отображено 100.
05-01-2012 дата публикации

Biosensor coated with electroactive polymer layer demonstrating bending behavior

Номер: US20120004522A1

Disclosed is a biosensor coated with an electroactive polymer layer demonstrating a bending behavior, more specifically a biosensor including an electroactive polymer layer coated on the surface of a bioreceptor and an electrode connected to the electroactive polymer layer. When an electrical stimulation is applied to the electrode, the electroactive polymer layer shows a bending behavior and thus the surface of the bioreceptor can be exposed to an analyte to allow a concentration analysis of the analyte. When used as an implantable biosensor, the disclosed biosensor may have a substantially increased life span since the bioreceptor can be selectively exposed to the analyte.

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05-01-2012 дата публикации

Protrudent analyte sensor

Номер: US20120004524A1
Принадлежит: Medtronic Minimed Inc

The methods and apparatus for detecting an analyte in blood are useful for detecting an analyte in tissue of a subject. The apparatus comprises a sensor, which comprises an elongated conductive material having a protrudent end, the protrudent end comprising an electrode that detects the presence of an analyte; a substrate affixed to the conductive material; and a support having an external surface, a proximal end, and a distal end. The conductive material is positioned on the support and the protrudent end of the conductive material protrudes beyond the distal end of the support. Optionally, the sensor is suspended within the lumen of a venous flow device. Typically, only a portion of the sensor is suspended within the lumen of the venous flow device, said portion comprising the protrudent end of the conductive material. Alternatively, the conductive material is positioned on the external surface of the intravenous infusion catheter.

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05-01-2012 дата публикации

Implantable Remote Monitoring Sensor

Номер: US20120004528A1
Принадлежит: Alcon Research LLC

An exemplary implantable sensor includes a housing that generally conforms to a curvature of an anterior chamber of a patient's eye. A sensing device disposed in the housing is configured to detect physiological parameters and transmit a signal representing the physiological parameters. The exemplary sensor may be used to detect physiological parameters such as intraocular pressure, flow velocity of aqueous humor, blood sugar, and blood biochemicals.

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19-01-2012 дата публикации

Wireless data communication protocols for a medical device network

Номер: US20120016305A1
Принадлежит: Medtronic Minimed Inc

A fluid infusion system includes local “body network” devices, such as an infusion pump, a handheld monitor or controller, a physiological sensor, and a bedside or hospital monitor. The body network devices support communication of status data, physiological information, alerts, control signals, and other information between one another. In addition, the body network devices support networked communication of status data, physiological information, alerts, control signals, and other information between the body network devices and “external” devices, systems, or communication networks. The networked medical devices support a variety of wireless data communication protocols. In addition, the wireless medical devices support a number of dynamically adjustable wireless data communication modes to react to current operating conditions, application-specific data content, or other criteria.

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19-01-2012 дата публикации

Spatial needle guidance system and associated methods

Номер: US20120016316A1
Принадлежит: Ultrasonix Medical Corp

Methods and apparatus for positioning a elongate hollow member at a desired location in a body in a medical procedure are provided. A position marker is removably disposed within a sheath. The sheath may be disposable. The sheath and enclosed position marker may be inserted into a lumen of a member to be positioned. The position in space of the position marker may be monitored by a position sensor to provide real-time information regarding a position of the member. The spatial relationship between the position marker and member may be fixed by securing the mounting member to the sheath and securing the sheath to the member.

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26-01-2012 дата публикации

Biosensor unit and biosensor system

Номер: US20120018302A1
Принадлежит: Arkray Inc

The biosensor unit has a substrate composed of a subcutaneously retained part that is retained under the skin and a base part that is placed on the skin surface. The biosensor unit comprises a sensor part detecting numerical information regarding a substance to be measured as electric signals, a signal amplifying part amplifying the electric signals, a CPU including a calculation part A/D converting the amplified electric signals and processing them to create transmittable data, a storage storing electric signals and data, a transmission part transmitting data to an external device through optical communication, and a battery part for drive. The sensor part is provided on the subcutaneously retained part and the transmission part is provided on the base part.

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26-01-2012 дата публикации

Using muscle tension sensing to locate an analyte measurement site on the skin

Номер: US20120022347A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

Apparatus for determining where to locate a measuring device ( 3 ) on skin, the apparatus having a muscle tension sensing device ( 1 ) arranged to sense muscle tension at different locations on the skin, and a processor ( 2 ) for determining and outputting an indication of where to locate the measuring device on the muscle, based on the sensed muscle tensions. This can help make the skin measurements such as non invasive glucose measurements more consistent, and more accurate.

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09-02-2012 дата публикации

Lancing device for one skin puncture

Номер: US20120035640A1
Автор: John P. Creaven
Принадлежит: Bayer HealthCare LLC

A lancing device comprises a main housing, a movable housing, and a damping ring. The main housing forming an inner aperture that encloses a portion of a lancet assembly. The lancet assembly has a lancet body, a lancet-plunger housing, and a lance. The lancet assembly is adapted to move between a resting position, a cocking position, and a puncture position. The movable housing is adjacent to the main housing. The moveable housing is adapted to move from a resting position to a cocking position. The moveable housing is adapted to connect to the lancet assembly. The damping ring is adapted to engage the lancet assembly as the lancet assembly moves from the puncture position back towards the resting position to reduce movement of the lancet assembly back towards the puncture position.

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01-03-2012 дата публикации

Non-Invasive Tissue Glucose-Level Monitoring

Номер: US20120053429A1
Принадлежит: Individual

A non-invasive analyte monitoring instrument has a radiation source for directing excitation radiation to a portion of a surface of a tissue wherein said source emits radiation at a plurality of different wavelengths that excites a target in said tissue causing said target to emit radiation such that the radiation received at the surface provides an analyte level indication of the patient. A radiation detector positioned to receive radiation emitted from the surface wherein said radiation detector is configured to synchronously scan radiation emitted by the target with the excitation radiation. A processing circuit operatively connected to the radiation detector that translates radiation received at the surface to a measurable signal to obtain said analyte level indication, wherein said radiation source comprises a visible light source or an ultraviolet light source and wherein the target is selected from the group consisting of a structural matrix tissue component, a cellular tissue component, a mitochondrial tissue component, a collagen cross link, a pepsin-digestible collagen cross link, a collagenase-digestible collagen cross link, a non-pepsin digestible collagen cross link, an elastin cross link, a tryptophan-containing protein, NADH, FAD, a flavoprotein, and any combination thereof.

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22-03-2012 дата публикации

Lancet integrated test element tape dispenser

Номер: US20120067006A1
Автор: Daniel Wong, Frank A. Chan
Принадлежит: Roche Diagnostics Operations Inc

A lancet integrated test element tape includes a plurality of lancet integrated test elements. The lancet integrated test elements each include a lancet configured to form an incision in tissue and a test element configured to analyze body fluid from the incision in the tissue. A cartridge includes a supply compartment configured to store an unused section of the tape. The tape is folded within the supply compartment to limit damage to the lancet integrated test elements. The cartridge can further include a waste compartment in which a used section of the tape is stored. An indexing mechanism moves the tape between the supply and waste compartments.

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26-04-2012 дата публикации

Molecular exchange device

Номер: US20120097600A1
Принадлежит: Probe Scientific Ltd

The present relates to a molecular exchange device. In particular, the molecular exchange device comprises at least one fluid passageway; and an actuator, the actuator positioned to provide a secondary fluid passageway within at least one of the fluid passageways.

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03-05-2012 дата публикации

System and/or method for glucose sensor calibration

Номер: US20120108933A1
Принадлежит: Medtronic Minimed Inc

The subject matter disclosed herein relates to systems, methods and/or devices for calibrating sensor data to be used in estimating a blood glucose concentration. A relationship between sensor signal values and reference readings may be used to estimate a relationship between sensor signal values and measurements of blood glucose concentration.

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17-05-2012 дата публикации

Real-time self-calibrating sensor system and method

Номер: US20120123690A1
Принадлежит: Medtronic Minimed Inc

A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.

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24-05-2012 дата публикации

Determination and application of glucose sensor reliability indicator and/or metric

Номер: US20120125075A1
Принадлежит: Medtronic Minimed Inc

Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.

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24-05-2012 дата публикации

Analyte sensor

Номер: US20120130214A1
Принадлежит: Dexcom Inc

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

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07-06-2012 дата публикации

Device, system and method for meal detection for interfacing with and controlling auxiliary devices associated therewith

Номер: US20120143021A1
Автор: Ron Nagar
Принадлежит: Insuline Medical Ltd

The present invention relates to a device, system and method for detecting meal event in a subject and in particular to such a device, system and method for communicating and controlling auxiliary devices and/or systems associated therewith.

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14-06-2012 дата публикации

Blood collection devices containing blood stabilization agent

Номер: US20120149004A1
Принадлежит: Becton Dickinson and Co

Disclosed are devices for collecting and stabilizing blood that contain a blood stabilization agent which includes variegin or an analog thereof, a polysulfated disaccharide, or a combination thereof, each in an amount effective to stabilize blood. Methods of making and using the devices, and kits containing the devices, are also provided.

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14-06-2012 дата публикации

Transdermal Sampling and Analysis Device

Номер: US20120150004A1
Принадлежит: Flexible Medical Systems LLC

Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir where the biological sample may chemically react with a biologically reactive element. A sensor may convert the produced electrons (ions) into measured electrical signals. The converted signals may be measured and the levels of an analyte may be determined based on the measured signals.

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14-06-2012 дата публикации

Adhesive and peripheral systems and methods for medical devices

Номер: US20120150115A1
Принадлежит: Deka Products LP

Fill stations and base stations are provided for personal pump systems. The fill stations may be opened and closed to accept a reservoir and to allow fluid to be introduced into the reservoir for use with personal pump systems. The fill stations may hold the reservoir at a tilt relative to an underlying surface and may discourage overfilling of the reservoir. The filling stations may also include viewing windows having fluid lines marked thereon for indicating volume of fluid within the reservoir.

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05-07-2012 дата публикации

Blood collection device

Номер: US20120172754A1
Автор: Rishi Baid
Принадлежит: Poly Medicure Ltd

The application relates to a blood collection device comprising: a cannula hub ( 10 ) defining a chamber ( 28 ); an inlet cannula ( 12 ) defining an axis and having a distal end and a lumen extending therethrough, the inlet cannula being mounted to the cannula hub such that the distal end of the inlet cannula is external of the cannula hub and such that the lumen through the inlet cannula communicates with the chamber; an outlet cannula ( 14 ) having a proximal end and a lumen extending therethrough, the outlet cannula being mounted to the cannula hub such that the proximal end of the outlet cannula is external of the cannula hub and such that the lumen of the outlet cannula communicates with the chamber; a closed sleeve ( 34 ) mounted over a portion of the outlet cannula disposed externally of the cannula hub; and a venting mechanism ( 38 ) providing communication between the chamber and ambient surroundings.

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12-07-2012 дата публикации

Injection device with puncture function, method for controlling injection device with puncture function, chemical solution administration device, and method for controlling chemical solution administration device

Номер: US20120179016A1
Принадлежит: Individual

An injection device with a puncture function includes, in a single casing, a cylindrical cartridge in which insulin is enclosed, a cartridge holder to which the cartridge is inserted, a needle inserted at a front end of the cartridge, a reciprocation unit for reciprocating the cartridge toward the needle, and an extrusion member for extruding the insulin from a rear end of the cartridge toward the needle, and the motion speed and the motion amount of the reciprocation unit are made variable.

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02-08-2012 дата публикации

Method of Calibrating an Analyte-Measurement Device, and Associated Methods, Devices and Systems

Номер: US20120197576A1
Принадлежит: Abbott Diabetes Care Inc

The invention relates to a method for calibrating an analyte-measurement device that is used to evaluate a concentration of analyte in bodily fluid at or from a measurement site in a body. The method involves measuring a concentration, or calibration concentration, of an analyte in blood from an “off-finger” calibration site, and calibrating the analyte-measurement device based on that calibration concentration. The invention also relates to a device, system, or kit for measuring a concentration of an analyte in a body, which employs a calibration device for adjusting analyte concentration measured in bodily fluid based on an analyte concentration measured in blood from an “off-finger” calibration site.

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09-08-2012 дата публикации

Analyzing Device, Sensor Testing Device, Testing Method and Computer-Readable Storage Medium

Номер: US20120199496A1
Автор: Shinjiro Sekimoto
Принадлежит: Arkray Inc

There is provided a sensor testing method including: applying at least one of a first voltage that obtains a response caused by a substance and a second voltage that either obtains no response or substantially no response caused by the substance across a first electrode and a second electrode of a sensor; measuring current flowing between the first electrode and the second electrode; and determining whether or not there is a defect present in the sensor based on a quantity related to an amount of change per specific period of time of a current measured when the first voltage and/or the second voltage have been applied.

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16-08-2012 дата публикации

Patch-sized fluid delivery systems and methods

Номер: US20120209179A1
Принадлежит: Deka Products LP

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

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16-08-2012 дата публикации

Adhesive and peripheral systems and methods for medical devices

Номер: US20120209207A1
Автор: Eric Yeaton, Larry B. Gray
Принадлежит: Deka Products LP

A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.

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23-08-2012 дата публикации

Method to recalibrate continuous glucose monitoring data on-line

Номер: US20120215087A1
Принадлежит: UNIVERSITA DEGLI STUDI DI PADOVA

In a method of recalibrating continuous glucose monitoring data from a user, operable on a digital processor, an indication from the user that the user has taken a meal is received ( 806 ). A self-monitored of blood glucose levels from the user ( 810 ) at two separate times during a day corresponding to when the user has taken a meal. A glucose signal is received from a continuous glucose monitoring sensor ( 818 ) at times corresponding to the two separate times that the user has taken a meal. Two reconstructed blood glucose values based on the glucose signal from the continuous monitoring sensor at times when the at least two self-monitored of blood glucose levels are received from the user. A linear regression is performed ( 822 ) using y=ax+b, wherein x corresponds to the two reconstructed blood glucose values and y corresponds to the two self-monitored of blood glucose levels thereby generating an estimation of a and b. A recalibration signal, including the estimation of a and b, is transmitted to the continuous glucose monitoring sensor ( 824 ) based on the linear regression.

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23-08-2012 дата публикации

Integrated spot monitoring device with fluid sensor

Номер: US20120215132A1
Принадлежит: Roche Diagnostics Operations Inc

A bodily fluid sampling device is operable to breach the skin surface and allow bodily fluid to emerge from the breach location. The bodily fluid sampling device further evaluates the amount of bodily fluid emerged from breach location and determines whether the amount is sufficient or insufficient for a particular purpose, such as sampling and testing. The determination is accomplished automatically without moving the device. The user may also intervene to perform a variety of tasks following the determination of the amount of bodily fluid.

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30-08-2012 дата публикации

Alignment mechanism for cartridge-based devices

Номер: US20120220895A1
Автор: Doug Vine, Gil KAN
Принадлежит: Facet Technologies LLC

A lancing device and a cartridge of lancets are operable to sequentially advance each lancet to an active position for use in sampling a bodily fluid. An alignment mechanism precisely aligns the lancets in the active position to promote smooth operation and prevent jamming. The alignment mechanism includes at least one register element and at least one spring-biased element movable between engaged and retracted positions. In an example embodiment, one spring-biased arm extends from the lancing-device housing and includes a protrusion, and a series of recessed register surfaces are defined in a carrier for the lancets. In the engaged position, the spring-biased protrusion fully mates with the register recess under the spring-biasing influence to precisely align the active lancet. And in the retracted position, the spring-biased protrusion is deflected from engagement with the register recess as the carrier is advanced to advance a fresh lancet into the active position.

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13-09-2012 дата публикации

Bodily fluid composition analyzer with disposable cassette

Номер: US20120232362A1
Принадлежит: Optiscan Biomedical Corp

Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

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20-09-2012 дата публикации

System and methods for determination of analyte concentration using time resolved amperometry

Номер: US20120234700A1
Автор: David Deng
Принадлежит: Nipro Diagnostics Inc

A method for determining a concentration of an analyte is disclosed. The method includes applying a potential excitation to a fluid sample containing an analyte and determining if a current decay curve associated with the fluid sample has entered an analyte depletion stage. The method also includes measuring a plurality of current values associated with the fluid sample during the analyte depletion stage and calculating an analyte concentration based on at least one of the plurality of current values.

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27-09-2012 дата публикации

Glucose Monitoring System

Номер: US20120245445A1
Принадлежит: Individual

A body fluid sampling system for use on a tissue site includes a drive force generator and one or more microneedles operatively coupled to the drive force generator. Each of a microneedle has a height of 500 to 2000 μm and a variable tapering angle of 60 to 90°. A sample chamber is coupled to the one or more microneedles. A body fluid is created when the one or more microneedles pierces a tissue site flows to the sample chamber for glucose detection and analysis.

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04-10-2012 дата публикации

Method for detecting a malfunction of a sensor for measuring an analyte concentration in vivo

Номер: US20120249158A1
Принадлежит: Roche Diagnostics Operations Inc

The invention relates to a method for detecting a malfunction of a sensor for measuring an analyte concentration in vivo, wherein a series of measurement signals is produced by means of the sensor, and a value of a noise parameter is continually determined from the measuring signals, the noise parameter indicating how severely the measurement is impaired by interference signals. According to the invention, continually determined values of the noise parameter are used to determine how quickly the noise parameter changes, and the rate of change of the noise parameter is evaluated to detect a malfunction.

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04-10-2012 дата публикации

Transdermal systems, devices, and methods for biological analysis

Номер: US20120252046A1
Принадлежит: Bayer HealthCare LLC

A transdermal test sensor includes a test chamber including a liquid, a reagent system in contact with the liquid, a housing containing the liquid, and a semipermeable membrane. The housing includes an opening, the semipermeable membrane is connected to the housing and covers the opening, and the housing and the semipermeable membrane enclose the liquid and the reagent system. The transdermal test sensor also includes an analyzer in communication with the liquid. When porated tissue is contacted with the semipermeable membrane and sufficient time is allowed for a fluid sample to traverse the porated tissue and for an analyte in the fluid sample to enter the liquid in the transdermal sensor through the semipermeable membrane, a change in at least one optical property or at least one electrical property of the liquid is detected. The change detected is then correlated with the analyte concentration in the fluid sample.

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18-10-2012 дата публикации

Advanced analyte sensor calibration and error detection

Номер: US20120265037A1
Принадлежит: Dexcom Inc

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

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25-10-2012 дата публикации

Integrated lancing device

Номер: US20120271123A1

A lancing device is provided that has a housing with a length greater than a width. Electronics are positioned in an interior of the housing. A test strip aperture is in the housing and is adapted to receive a body fluid test strip. A lancet aperture is positioned in line with the test strip aperture.

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25-10-2012 дата публикации

Apparatus for obtaining and analyzing a blood sample with a lancet coupling mechanism

Номер: US20120271126A1
Автор: Hans List, Kai Fluegge
Принадлежит: Roche Diagnostics Operations Inc

An apparatus for obtaining and analyzing a blood sample is presented. The apparatus comprises an integrated drive unit having a common drive source and a drive force transmission gearing that couples a lancet drive, a device for advancing a magazine, and a sample transfer device to the drive source. A tensioning rotor and a drive rotor are mounted so that they are rotatable coaxially to one another. A first cam control converts the rotation of the drive rotor into a radial forward and reverse movement of a drive rod. A second cam control converts the rotational movement of the tensioning rotor into a linear movement of a link slide. A switching link moved by the link slide rotates the magazine an additional step. A third cam control converts the rotational movement of the tensioning rotor into a linear movement of a pressure tappet perpendicular to the piercing axis.

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01-11-2012 дата публикации

Systems and methods for collecting fluid from a subject

Номер: US20120277697A1
Принадлежит: Seventh Sense Biosystems Inc

Systems and methods for delivering to and/or receiving fluids or other materials, such as blood or interstitial fluid, from subjects, e.g., from the skin. Beading disruptors and/or capillaries may be used for facilitating the transport of fluids from a subject into a device. Beading disruptors may disrupt the “pooling” of bodily fluids such as blood on the surface of the skin and help influence flow in a desired way. A capillary may conduct flow of fluid in the device, e.g., to an inlet of a channel or other flow path that leads to a storage chamber. A vacuum (reduced pressure relative to ambient) may be used to receive fluid into the device, e.g., by using relatively low pressure to draw fluid into the inlet of a channel leading to a storage chamber. The vacuum source may be part of the device.

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08-11-2012 дата публикации

Tissue penetration device

Номер: US20120283539A1

A body fluid testing device has at least one penetrating member and a penetrating member driver configured to be coupled to the at least one penetrating member. A plurality of analyte sensors are coupled to a spoked disk substrate. Each of a penetrating member can pass between spokes of the disk substrate to provide that a used penetrating member can be removed and a new penetrating inserted without removing the disk. A disposable houses the at least one penetrating member and the plurality of analyte sensors.

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22-11-2012 дата публикации

Manufacturing electrochemical sensor module

Номер: US20120291254A1
Автор: James L. Say
Принадлежит: Individual

Certain processes for manufacturing an electrochemical sensor module include assembly first and second housing portions of sensor modules; dispensing a sensor fiber across multiple first housing portions; joining the first and second housing portions; and separating the sensor modules by cutting the sensor fiber.

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13-12-2012 дата публикации

Enclosed desorption electrospray ionization probes and method of use thereof

Номер: US20120312979A1
Принадлежит: PURDUE RESEARCH FOUNDATION

The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

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13-12-2012 дата публикации

Safety Syringe Having A Manually Activated Retractable Needle

Номер: US20120316466A1
Принадлежит: Becton Dickinson and Co

A retractable needle assembly includes a housing having a sidewall defining a hollow bore, and an elongate plunger, the distal end of the plunger forming a reservoir within the hollow bore for containing a fluid therein. The plunger is adapted for slideable movement within the hollow bore. The assembly includes a hub disposed within the hollow bore and at least partially supporting a cannula therewith, and a needle retraction member engaged with the hub for manually selectable advancement with respect to a portion of the housing. The needle retraction member may be advanced from an initial position in which at least a portion of the needle is disposed outside the housing, to a retracted position in which the needle is fully surrounded by the housing. The elongate plunger may be advanced about the hub for extracting the fluid into the reservoir or expelling the fluid from the reservoir.

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20-12-2012 дата публикации

Article and Method for Applying a Coupling Agent for a Non-Invasive Optical Probe

Номер: US20120323093A1
Автор: Michael G. Lowery
Принадлежит: ABBOTT LABORATORIES

An article of manufacture and method for controlling the application of a coupling agent, such as a silicone oil or mineral oil, on a surface of a tissue prior to contacting the tissue with an apparatus for non-invasive optical measurement of the concentration of an analyte. The article ensures that a specific quantity of the coupling agent is deposited in a uniform layer over the entire target area of the tissue, thereby enhancing both the optical signal and the repeatability of thermal and optical coupling with the components of the apparatus.

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03-01-2013 дата публикации

Methods for Generating Hybrid Analyte Level Output, and Devices and Systems Related Thereto

Номер: US20130006081A1
Автор: Gary A. Hayter
Принадлежит: Abbott Diabetes Care Inc

Generally, methods, devices, and systems for generating a hybrid analyte level output are provided. The uncompensated analyte levels lag in time with respect to the lag-compensated analyte levels, and the hybrid analyte level output tracks between the uncompensated analyte levels and the lag-compensated analyte levels according to predetermined criteria.

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10-01-2013 дата публикации

Lancet, method for manufacturing the lancet, and mold for the method

Номер: US20130012976A1
Автор: Hirokazu Imori
Принадлежит: Asahi Polyslider Co Ltd

There is provided a process of producing a lancet which suppresses curving (or flexing) of the front end portion of the pricking member. In the production of a lancet by injection molding of a resin with a pricking member inserted in a mold, upon forming at least a portion of a lancet cap in which portion a molten resin supplied to the mold surrounds a front end portion of the pricking member, a mold is used which is configured such that at least a portion of the molten resin which forms said portion of the lancet cap flows along the front end portion including a leading end of the pricking member toward its leading end.

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17-01-2013 дата публикации

Method for the Production of Bodies in Plastic Material Comprising at Least Two Portions Hinged to Each Other by a Single Rotation Pin

Номер: US20130015605A1
Принадлежит: Meus Srl

The present invention relates to a method for the production of bodies in plastic comprising two portions hinged to each other by a single rotation pin. The method comprises the steps: a) predisposing a mould with two distinct forming chambers for the two portions; the mould comprises a third chamber for the single pin, made and positioned in such a way that the pin is formed already aligned along the hinge axis; the mould is provided with a pair of pegs axially distanced from each other to form the third chamber and sliding along the axis between a first and a second operating position; b) positioning the pegs in the first position; c) injecting plastic material inside the chambers; d) shifting the pegs from the first to the second position, bringing the pin to engage inside the seats; e) opening the mould and extracting the two assembled portions.

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17-01-2013 дата публикации

Budget Your Weight System

Номер: US20130018244A1
Принадлежит: Individual

A system and method of monitoring a person's health information is disclosed. The method comprises the steps of providing a computer program algorithm accessible by a computer processing device and providing at least one monitor in electronic communication with the computer processing device wherein the monitor is configured to transmit the person's physical data to the computer processing device, and the algorithm is configured to store the physical data, average the physical data over one or more predetermined periods of time, and report the physical data in one or more predetermined formats. The computer processing device may be a cellular telephone, tablet computer, laptop computer, desktop computer, server, or networked computing device. The monitor may be any one of a pedometer, a heart rate monitor, a body temperature monitor, a blood glucose monitor, a blood pressure monitor, or a monitor configured to collect physical data from one or more of a person's body fluids. In some embodiments, the method is used to monitor a person's caloric balance, which may be computed or estimated.

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14-02-2013 дата публикации

Arrangement for detection of hemolysis

Номер: US20130040333A1
Автор: Mathias Karlsson
Принадлежит: Hemcheck Sweden Ab

The present invention relates to a device for visual detection of hemolysis in a whole blood sample, comprising at least one visible detection compartment and a transfer passage connected to said visible detection compartment, said transfer passage being arranged to permit transfer of a volume of plasma from said sample to said detection compartment and wherein said transfer passage further is arranged with a separation device ( 4 ) for separating plasma from blood cells within said whole blood sample before said plasma reaches the detection compartment, wherein said device is arranged with subpressure means providing a subpressure inside said detection compartment for generating a force urging said volume of plasma to be transferred from said whole blood sample to said detection compartment through said transfer passage and via said separation device.

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14-02-2013 дата публикации

Living body information measuring apparatus

Номер: US20130041237A1
Автор: Shoichi Kanayama
Принадлежит: Shoichi Kanayama

A living body information measuring apparatus includes an optical system for irradiating light to a subject and detecting light from the subject, a signal processing portion for acquiring information with regard to a tissue condition of the subject based on a detecting signal of light, and a position determining portion for determining an acceptability of an irradiating position of light based on the detecting signal of light.

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28-02-2013 дата публикации

Reference Electrodes Having an Extended Lifetime for use in Long Term Amperometric Sensors

Номер: US20130053667A1
Принадлежит: Abbott Diabetes Care Inc

The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions.

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07-03-2013 дата публикации

Methods for Subcutaneously Positioning an Analyte Sensing Device

Номер: US20130060099A1
Принадлежит: Abbott Diabetes Care Inc

Aspects of the present disclosure include methods for determining the presence and/or concentration of an analyte. In practicing methods according to certain embodiments, an analyte sensing unit is positioned at a location on the abdomen of a that experiences involuntary movement sufficient to provide for mixing of non-circulating interstitial fluid with circulating interstitial fluid and determining an analyte concentration in the interstitial fluid. Also provided are methods for positioning an analyte sensing unit at a location on the abdomen of a subject, and methods of determining an analyte concentration while the subject is asleep, e.g., during a rapid eye movement (REM) sleep period. Devices and systems for practicing the subject methods also described.

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14-03-2013 дата публикации

Lancet Magazine and Method for the Production Thereof

Номер: US20130066171A1
Автор: Harttig Herbert
Принадлежит: ROCHE DIAGNOSTICS OPERATIONS, INC.

A lancet magazine is disclosed which includes a housing and a plurality of lancets each of which is enclosed in a sterile chamber of the housing, wherein the chambers each have a puncturing opening which is closed with a foil, wherein the lancets include a sample receiving device for receiving body fluid and the chambers each include a further opening which is closed with a membrane that is permeable to gas and fluid and includes a lower side that faces the lancet and serves to receive body fluid from the sample receiving device and an upper side that serves to transfer body fluid to a test field arranged on the membrane. 1. A lancet magazine , comprising a housing and a plurality of lancets each of which is enclosed in a sterile chamber of the housing , wherein the chambers each have a puncturing opening which is closed with a foil , wherein the lancets comprise a sample receiving device for receiving body fluid and the chambers each comprise a further opening which is closed with a membrane that is permeable to gas and fluid and comprises a lower side that faces the lancet and serves to receive body fluid from the sample receiving device and an upper side that serves to transfer body fluid to a test field arranged on the membrane.2. The lancet magazine of claim 1 , wherein the membrane is produced from a polymeric material.3. The lancet magazine of claim 2 , wherein the membrane is produced according to a phase inversion method.4. The lancet magazine of claim 1 , wherein the membrane is hydrophilic.5. The lancet magazine of claim 1 , wherein the membrane comprises pores on the lower side the size of which is in excess of that of the pores on the upper side.6. The lancet magazine of claim 1 , wherein the membrane is a sheet that covers a plurality of chamber openings.7. The lancet magazine of claim 1 , wherein the lancet tips are in contact with a gas contained in the chambers.8. The lancet magazine of claim 1 , wherein the sample receiving device comprises a ...

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14-03-2013 дата публикации

Integrated Lancet and Analyte Testing Apparatus

Номер: US20130066179A1
Принадлежит: ABBOTT DIABETES CARE INC.

Integrated lancing and analyte measurement systems are provided which minimize the number of actions required to operate the systems, accomplished in part by combining two or more user steps into one. 134-. (canceled)35. A method of using an integrated analyte measurement system , the method comprising:pulling a lever to advance a test strip through a first aperture in a housing and to arm a lancet positioned within the housing for firing through a second aperture in the housing; andpressing a button within the housing to fire the lancet through the second aperture into the skin.36. The method of claim 35 , further comprising contacting an exposed end of the test strip with body fluid extracted from the skin and measuring an analyte level within the body fluid by means of electronics within the housing.37. The method of claim 35 , further comprising moving a switch within the housing to rearm the lancet without advancing a test strip.38. The method of claim 35 , further comprising containing a plurality of test strips within the housing in a hermetically sealable condition claim 35 , wherein pulling the lever momentarily unseals the test strips.39. The method of claim 35 , further comprising selectively adjusting the height of a skin-contacting structure extending from the housing at the first aperture.40. The method of claim 35 , further comprising claim 35 , prior to pushing the button claim 35 , pushing the lever in the opposite direction. This application claims the benefit of U.S. Provisional Patent Application Ser. No. 61/102,640 filed on Oct. 3, 2008, which is hereby incorporated by reference in its entirety.There are a number of instances when it is desirable or necessary to test or monitor the concentration of an analyte, such as glucose, lactate, or oxygen, for example, in bodily fluid of a body. Bodily sample analyte tests are routinely conducted in a variety of medical settings (e.g., doctor's office, clinic, hospital, by medical personnel) and in the ...

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14-03-2013 дата публикации

Vessel for blood sampling

Номер: US20130066234A1
Автор: Elke Helftenbein
Принадлежит: PreAnalytiX GmbH

The present invention relates to a vessel for withdrawing blood, the vessel containing a solution which comprises a guanidinium salt, a buffer substance, a reducing agent, and/or a detergent as components. The vessel is particularly suited for withdrawing blood which is to be analyzed with respect to nucleic acids.

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21-03-2013 дата публикации

INTRAVASCULAR GLUCOSE SENSOR

Номер: US20130072768A1
Принадлежит:

A glucose sensor for intravascular measurement of glucose concentration wherein the sensor is arranged to measure glucose concentration by monitoring the lifetime of the fluorophore, the sensor comprising:—an indicator system comprising a receptor for selectively binding to glucose and a fluorophore associated with said receptor, wherein the fluorophore has a life-time of less than 100 ns;—a light source;—an optical fibre arranged to direct light from the light source onto the indicator system; —a detector arranged to receive fluorescent light emitted from the indicator system; and—a signal processor arranged to determine information related to a fluorescence lifetime of the fluorophore based on at least the output signal of the detector. 1. A glucose sensor for intravascular measurement of glucose concentration wherein the sensor is arranged to measure glucose concentration by monitoring the lifetime of the fluorophore , the sensor comprising:an indicator system comprising a receptor for selectively binding to glucose and a fluorophore associated with said receptor, wherein the fluorophore has a lifetime of less than 100 ns;a light source;an optical fibre arranged to direct light from the light source onto the indicator system;a detector arranged to receive fluorescent light emitted from the indicator system; anda signal processor arranged to determine information related to a fluorescence lifetime of the fluorophore based on at least the output signal of the detector.2. A sensor according to claim 1 , wherein the detector is a single photon avalanche diode.3. A sensor according to claim 2 , further comprising:a driver arranged to modulate the light source intensity at a first frequency;a bias voltage source arranged to apply a bias voltage to the single photon avalanche diode, wherein the bias voltage is modulated at a second frequency, different from the first frequency, and wherein the bias voltage is above the breakdown voltage of the single photon avalanche ...

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21-03-2013 дата публикации

LANCING DEVICE AND LANCET

Номер: US20130072818A1
Принадлежит: FACET TECHNOLOGIES, LLC

A lancing device and lancet are provided with depth-control, lancet ejection, and/or guidance mechanisms. The depth-control mechanism includes a dial rotationally mounted at a distal end of the housing of the lancing device, the dial being coupled to a linkage whereby rotation of the dial imparts translational movement to a stop surface of the linkage to limit the stroke of the lancet and thereby control lancing penetration depth. The ejection mechanism includes an ejector that is advanced into contact with a transversely flared flange of the lancet to discharge the lancet from the lancing device. The guidance mechanism includes an inner guidance housing for restricting out-of-axis movement of a lancet carrier. 1. A lancing device comprising:a lancet carrier comprising a lancet carrier stop;a drive spring for propelling the lancet carrier along a lancing stroke defining a stroke distance; and a dial that is rotational about a center of rotation, the dial further comprising a mounting pin eccentrically offset from the center of rotation; and', 'a stop bar having a first end mounted to the mounting pin of the dial and a second end comprising a stop surface for contact with the lancet carrier stop to adjust the stroke distance of the lancet carrier., 'a depth control mechanism comprising2. The lancing device of claim 1 , wherein the stop bar has a generally T-shaped profile with a lengthwise axis and a transverse rib forming the stop surface and extending generally perpendicular to the lengthwise axis.3. The lancing device of claim 1 , wherein the lancet carrier comprises a distal extension arm having the lancet carrier stop extending therefrom.4. The lancing device of claim 3 , wherein the lancet carrier stop comprises a sleeve retained on the distal extension arm.5. The lancing device of claim 1 , wherein rotation of the dial drives an axial component of motion of the stop bar and a transverse component of motion of the stop bar.6. The lancing device of claim 5 , ...

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28-03-2013 дата публикации

METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR IMPROVING THE ACCURACY OF GLUCOSE SENSORS USING INSULIN DELIVERY OBSERVATION IN DIABETES

Номер: US20130079613A1

Method and System for providing a signal from an insulin pump, artificial pancreas, or another insulin delivery device as a source of information for improving the accuracy of a continuous glucose sensor (CGS). The effect of using insulin information to enhance sensor accuracy is most prominent at low blood glucose levels, i.e. in the hypoglycemic range, which is critical for any treatment. A system for providing a filtering/state estimation methodology that may be used to determine a glucose state estimate at time t-τ. The estimation may be extrapolated to some future time t and then the extrapolated value is used to extract the blood glucose component. The blood glucose component of the extrapolation and the output of the CGS are weighted and used to estimate the blood glucose level of a subject. 1. A method for improving the accuracy of a glucose measurement device , said method comprising:using insulin delivery information to improve the accuracy of said glucose measurement device.2. The method of claim 1 , wherein said glucose measurement device is a continuous glucose device.3. The method of claim 1 , further comprising:obtaining a readout from said glucose measurement device;obtaining said insulin delivery information from an insulin delivery device;performing a first intermediary computation to obtain an output of said first intermediary computation using said readout from said glucose measurement device of the subject and said insulin delivery information; andperforming a second intermediary computation to obtain an output of said second intermediary computation using said output of said first intermediary computation.4. The method of claim 3 , wherein said glucose measurement device is a continuous glucose device.5. The method of claim 3 , wherein said first intermediary computation further comprises a Kalman Filter methodology.6. The method of claim 3 , wherein said first intermediary computation further comprises a method for filtering/state estimation ...

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28-03-2013 дата публикации

DELIVERING AND/OR RECEIVING FLUIDS

Номер: US20130079666A1
Принадлежит: Seventh Sense Biosystems, Inc.

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. 1. A device for receiving fluid from a subject , comprising:a housing including a device actuator and an opening to receive fluid into the housing;a vacuum chamber in the housing that is at a pressure less than ambient pressure;a flow control element between the vacuum chamber and the opening;a plurality of microneedles arranged to be inserted into a subject to cause fluid to be released from the subject;a deployment actuator to move the plurality of microneedles in a deployment direction toward or through the opening; anda retraction actuator to move the plurality of microneedles in a retraction direction away from the opening,wherein actuation of the device actuator actuates the deployment actuator to move the plurality of microneedles in the deployment direction, actuates the retraction actuator to move the plurality of microneedles in the retraction direction, and causes the flow control element to enable fluid communication between the opening and the vacuum chamber.2. The device of claim 1 , wherein the retraction actuator has an initial stored potential energy prior to any deployment movement of the deployment actuator claim 1 , and wherein release of the stored ...

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04-04-2013 дата публикации

Low-pressure packaging for fluid devices

Номер: US20130081960A1
Автор: Kevin Schott
Принадлежит: Seventh Sense Biosystems Inc

Certain aspects of the invention are generally directed to devices for withdrawing a substance from the skin and/or from beneath the skin of a subject, and/or for delivering a substance to the skin and/or to a location beneath the skin of a subject. In some embodiments, the devices may comprise one or more skin insertion objects, such as needles or microneedles. In some cases, the device also may comprise one or more vacuum chambers. In some aspects, the device may be contained within an environment able to assist with maintenance of such pressures. For example, a package containing such an environment may also have a pressure less than atmospheric pressure, and/or the package may be molded to the device or otherwise have a shape that does not contain substantial gases that can “leak” into the device and alter the pressure of any vacuum chambers that may be contained therein.

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04-04-2013 дата публикации

ANALYTE TESTING DEVICES

Номер: US20130085349A1
Автор: Goldman Marc, Shaanan Gad
Принадлежит: YOFIMETER, LLC

Systems, devices, techniques and methods are disclosed for implementing an actuator mechanism of an analyte testing device. In one aspect, a method to test an analyte includes advancing an analyte sensor from a first position within a sensor cartridge of an analyte testing device to a second position that exposes at least a portion of the analyte sensor outside of the device, advancing a lancet projecting component from an initial position to a cocked position for a subsequent projection of a lancet, in which the advancing the analyte sensor and the advancing the lancet projecting component are initiated by a single operation, projecting the lancet to expose at least a portion of the lancet outside of the device, receiving a testing sample including an analyte at the exposed portion of the analyte sensor, processing the testing sample to determine a parameter of the analyte, and ejecting the analyte sensor from the device. 1. A method for operating an analyte testing device in testing an analyte , comprising:advancing an analyte sensor from a first position within a sensor cartridge of an analyte testing device to a second position to expose at least a portion of the analyte sensor outside of the device;advancing a lancet projecting component of the analyte testing device from an initial position to a cocked position for a subsequent projection of a lancet, wherein the advancing the analyte sensor and the advancing the lancet projecting component are initiated by a single operation;operating the lancet projecting component to project the lancet outside of the device;operating the device to contact the analyte sensor with a testing sample containing the analyte at the exposed portion of the analyte sensor;operating the device to process the testing sample to determine a parameter of the analyte; andejecting the analyte sensor from the device.2. The method of claim 1 , wherein the single operation includes sliding a button located on an external side of the device.3. ...

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04-04-2013 дата публикации

Controlling Transfer of Objects Affecting Optical Characteristics

Номер: US20130085352A1
Принадлежит: PALO ALTO RESEARCH CENTER INCORPORATED

An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte. 1. An article comprising:first and second parts; each of the first and second parts including a respective container and being operable as an optical cavity with a respective optical spectrum characteristic that can be affected by presence of spectrum-affecting objects in the container; the respective container having a respective set of one or more bounding regions through which objects in fluid can transfer between the container's interior and; andfirst and second fluidic components that control transfer of objects in bodily fluid through the respective bounding regions of the first and second parts, respectively; the first fluidic component permitting transfer of a first set of the spectrum-affecting objects into the first container at a more rapid rate than spectrum-affecting objects not in the first set; the second fluidic component permitting transfer of a second set of the spectrum-affecting objects into the second container at a more rapid rate ...

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04-04-2013 дата публикации

Methods for Analyte Monitoring Management and Analyte Measurement Data Management, and Articles of Manufacture Related Thereto

Номер: US20130085358A1
Принадлежит: Abbott Diabetes Care Inc

Generally, methods of analyte monitoring management, and articles of manufacturing related thereto, are provided. The methods include receiving analyte measurement data and analyzing the analyte measurement data for health related parameters. Recommendations are determined for creating or modifying a treatment program based on the analysis, and provided within a user-interface that enables a user to create or modify the treatment program. Further, generally, methods of for managing analyte measurement data, and articles of manufacturing related thereto, are provided. The methods include receiving analyte measurement data that represent data collected over a time period, and analyzing the analyte measurement data for analyte episodes within that time period. Threshold based episodes and/or rate-of-change based episodes may be determined.

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04-04-2013 дата публикации

System and Method for Monitoring Time Intervals During Blood Parameter Monitoring

Номер: US20130085471A1
Принадлежит: B Braun Melsungen AG

A system and method for monitoring at least one blood parameter of the blood of different patients, comprising a plurality of access devices for establishing at least one means of access to the blood of each patient through the skin, a plurality of removal devices for removing a quantity of blood from each patient in order to obtain at least one blood sample, at least one blood analysis device for analysing the blood sample with respect to predeterminable blood parameters and for generating individual blood parameter data sets, a calculation device which can be used jointly for a plurality of blood parameter data sets of different patients for calculating data sets of drug parameters of the drugs to be administered to the respective patient on the basis of the individual blood parameter data sets, and a plurality of supply devices for supplying the respective drug having the calculated drug parameters.

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04-04-2013 дата публикации

Lancing Aid Having Automatic Triggering

Номер: US20130085517A1
Автор: Michael Keil
Принадлежит: Roche Diagnostics Operations Inc

The present application concerns a system for the withdrawal of body fluids comprising a coupled tensioning and triggering mechanism, wherein the triggering mechanism is mechanically coupled to the tensioning mechanism in such a manner that the puncturing process is automatically triggered by successive continuation of the tensioning movement when the tensioning mechanism is actuated and wherein the lancing process triggered in this manner is carried out by a lancet.

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11-04-2013 дата публикации

ANALYTE SENSOR METHOD AND APPARATUS

Номер: US20130090536A1
Принадлежит:

Provided herein are systems, methods, and apparatuses for an analyte sensor. In one aspect, an analyte sensing device comprises a sensor body member including at least one nanopore and an optical conduit in optical communication with the sensor body member. The optical conduit transmits optical energy to the sensor body member and receives reflected optical energy back from the sensor body member. A photodetector is optically coupled to the optical conduit to determine an optical parameter from the reflected optical energy. 1a. a sensor body member including at least one nanopore;b. an optical conduit in optical communication with the sensor body member and the nanopore, wherein the optical conduit transmits optical energy to the sensor body member and receives optical energy from the sensor body member; andc. a photodetector optically coupled to the optical conduit to determine an optical parameter from the sensor body member.. An analyte sensing device comprising: The present application claims the benefit of U.S. Provisional Application Ser. No. 60/864,280, filed Nov. 3, 2006. The aforementioned application is herein incorporated by reference in its entirety.The present invention relates generally to analyte sensors. More specifically, the invention relates to analyte sensors using Optical Coherence Tomography (OCT).In OCT, light from a broad band light source is split by an optical fiber splitter with one fiber directing light to a sample path and the other optical fiber directing light to a reference path mirror. The distal end of the sample path can be interfaced with a scanning device, or the like. The reflected light from the scanning device is recombined with the signal from the reference mirror forming interference fringes (measured by a photovoltaic detector) allowing precise depth-resolved imaging or optical measurements to be taken. OCT has the potential to measure the concentrations of numerous analytes.While there are numerous procedures to measure ...

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25-04-2013 дата публикации

IMPLANTABLE SENSOR DEVICE AND SYSTEM

Номер: US20130102858A1
Принадлежит: ST. JUDE MEDICAL AB

The implantable medical device for measuring pressure is disclosed. The implantable medical device is connectable to a medical lead and comprises an outer sheath and a helically shaped needle arranged at the outer sheath. A pressure sensing body having a distal part is movably arranged in the outer sheath. The pressure sensing body is arranged such that the distal part is located within the outer sheath in an initial state of the pressure sensing body, wherein the pressure sensing body is arranged to be advanced from the initial state to protrude from the outer sheath and such that it is at least partially surrounded by the helically shaped needle; and a pressure sensor arranged at or adjacent to the distal part of the pressure sensing body for sensing pressure. 115-. (canceled)16. An implantable medical device for measuring pressure connectable to a medical lead , comprising:an outer sheath;a helically shaped needle arranged at said outer sheath;a pressure sensing body having a distal part and being movably arranged in said outer sheath, said pressure sensing body being arranged such that said distal part is located within said outer sheath in an initial state of said pressure sensing body, wherein said pressure sensing body is arranged to be advanced from said initial state to protrude from said outer sheath such that it is at least partially surrounded by said helically shaped needle; anda pressure sensor arranged at or adjacent to said distal part of said pressure sensing body for sensing pressure.17. The implantable medical device according to claim 16 , wherein said helically shaped needle is fixed at said outer sheath or at a distal element fitted in a distal opening of said outer sheath.18. The implantable medical device according to claim 17 , wherein said distal element comprises a through hole arranged such that said pressure sensing body can be advanced through said through hole.19. The implantable medical device for measuring pressure connectable to a ...

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25-04-2013 дата публикации

GLYCEMIC HEALTH METRIC DETERMINATION AND APPLICATION

Номер: US20130102867A1
Принадлежит: Medtronic Minimed, Inc.

Disclosed are methods, apparatuses, etc. for determination and application of a metric for assessing a patient's glycemic health. In one particular implementation, a computed metric may be used to balance short-term and long-term risks associated with a particular therapy. 1. A method comprising:at a special purpose computing apparatus, computing a profile of a blood glucose concentration of a patient based, at least in part, on observations of said blood glucose concentration collected at a blood glucose monitoring device, said profile comprising at least a computed mean blood glucose concentration and an indication of a statistical dispersion;applying a cost or loss function to said computed profile to compute a metric representative of a glycemic health of the patient, said cost or loss function being based, at least in part, on an application of a log-square operation to at least one of the computed mean or said indication of said statistical dispersion; andaffecting a therapy applied to said patient based, at least in part, on said computed metric.2. The method of claim 1 , wherein said indication of said statistical dispersion comprises a standard deviation.3. The method of claim 1 , wherein said metric comprises a unidimensional metric.4. The method of claim 1 , wherein affecting said therapy comprises setting a target blood glucose level or target blood glucose range of said patient based claim 1 , at least in part claim 1 , on said computed metric.5. The method of claim 1 , wherein said loss or cost function is further based claim 1 , at least in part claim 1 , on application of a log-square function to a target blood glucose concentration value.6. The method of claim 5 , wherein said metric substantially has the form:{'br': None, 'i': G', 'G, 'sub': T', '10', '10', 'T, 'sup': 2', '2, 'Loss()=log(σ)+[log 10(μ)−log()], where{'sub': 'T', 'Gis the target blood glucose concentration value;'}μ is the computed mean; andσ is the measure of the statistical ...

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02-05-2013 дата публикации

Simultaneous acquisition of biometric data and nucleic acid

Номер: US20130106568A1
Принадлежит: Life Technologies Corp

Disclosed are devices and methods for collection and analyzing biological samples containing nucleic acid in conjunction with collecting at least one ridge and valley signature of a test subject, while keeping the sample and signature associated with each other. Such devices and methods are used in forensic, human identification, screening, and access control technologies to rapidly process an individual's identity or determine the identity of an individual.

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02-05-2013 дата публикации

Inserter for a Multiplicity of Subcutaneous Parts

Номер: US20130110047A1
Автор: Steffen Gyrn
Принадлежит: Unomedical AS

A holding device and an inserter are provided. The holding device includes a casing providing a cavity including walls, the was encompass a subcutaneous unit. The cavity includes a first side having an outlet opening, the outlet opening before use is covered with a penetrable or removable cover, and a second side comprising a layer having an outer surface and being penetrable, removable or flexible to transfer an impact from outside the layer to the subcutaneous unit. The casing includes a releasable attachment member corresponding to a member on the subcutaneous unit and a needle secured to the casing. An impact towards the outer surface of the layer pushes the subcutaneous unit at least partly out of the casing into a subcutaneous position, when the unit is in the subcutaneous position the releasable attachment member of the casing is released allowing detachment of the unit from the casing.

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09-05-2013 дата публикации

Sample cell for fluid analysis system

Номер: US20130114068A1
Автор: Eugene Lim, Roger Tong
Принадлежит: Optiscan Biomedical Corp

Systems and method are disclosed for determining a concentration of an analyte (e.g., glucose) in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A centrifuge motor can spin the sample cell to separate the fluid into a plurality of components (plasma, red blood cells, etc.). A particular component of the fluid (e.g., plasma) may be positioned at a sample portion of the sample cell after centrifuging such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a cuvette that has two window pieces sandwiched between two clamshell pieces, and where the sample portion of the sample cell is defined by a gap between the window pieces.

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09-05-2013 дата публикации

Analyte Monitoring Device and Methods

Номер: US20130116524A1
Принадлежит: ABBOTT DIABETES CARE INC.

Methods and devices for providing application specific integrated circuit architecture for a two electrode analyte sensor or a three electrode analyte sensor are provided. Systems and kits employing the same are also provided. 1. An analyte monitoring device , comprising:an analyte sensor having a plurality of sensor electrodes, the analyte sensor having at least a portion in fluid contact with interstitial fluid under a skin layer; and wherein the analog front end circuitry of the sensor electronics includes a single offset for calibration of the sensor electronics, and further', 'wherein the analog front end circuitry of the sensor electronics are referenced to a reference potential., 'sensor electronics coupled to the sensor electrodes of the analyte sensor and in signal communication with the analyte sensor, the sensor electronics including analog front end circuitry and programmed, or including programmable logic, to process signals generated by the analyte sensor and received by the analog front end circuitry, the signals generated by the analyte sensor corresponding to a monitored analyte level in the interstitial fluid;'}2. The device of wherein the analog front end circuitry is provided with a fixed voltage between a working electrode and a reference electrode of the sensor to reference the analog front end circuitry of the sensor electronics to the reference potential.3. The device of claim 2 , wherein the fixed voltage includes the poise voltage associated with the analyte sensor.4. The device of claim 1 , wherein the analyte sensor and the sensor electronics are included within an integrated housing.5. The device of claim 4 , wherein the integrated housing is configured to be worn on a skin surface of a patient.6. The device of claim 1 , wherein the analyte sensor is configured to operate for a period of at least 14 days.7. The device of claim 1 , wherein the sensor electronics includes a data communication component to communicate the processed signals ...

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09-05-2013 дата публикации

Analyte Monitoring Device and Methods of Use

Номер: US20130116525A1
Принадлежит: ABBOTT DIABETES CARE INC.

In aspects of the present disclosure, a multi compatible or universal blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that require calibration code and test strips that do not require calibration code. Also disclosed are methods, systems, devices and kits for providing the same. 1. A component of an in vivo continuous glucose monitoring system that determines glucose level by way of in vivo glucose sensors and in vitro glucose test strips , comprising:a test strip receiving port that receives coded in vitro glucose test strips that require user calibration action to calibrate the test strip and no-coded in vitro glucose test strips that do not require user calibration action to calibrate the test strip;a processor programmed to determine glucose concentration from electrical signal obtained from in vivo glucose sensors at least partially inserted into the skin of a user, and from both coded and non-coded in vitro glucose test strips received in the test strip receiving port by first determining if a received in vitro glucose test strip is a coded or non-coded test strip, selecting a coded or non-coded processing algorithm to process the signal once determined, and processing the signal to determine an in vitro glucose value; anda user interface configured to communicate glucose level determined by the processor.2. The component of claim 1 , further comprising programming to automatically determine if a received in vitro glucose test strip is a coded or a non-coded test strip.3. The component of claim 1 , further comprising user-selectable inputs that identify a received in vitro glucose test strip as a coded or a non-coded test strip.4. The component of claim 1 , wherein the processor is programmed to generate a request for a calibration code if a coded test strip is received in the test strip port.5. The component of claim 1 , ...

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09-05-2013 дата публикации

Analyte Sensor Calibration Management

Номер: US20130116527A1
Принадлежит: ABBOTT DIABETES CARE INC.

Methods and devices to detect analyte in body fluid are provided. Embodiments include positioning an analyte sensor in fluid contact with an analyte, detecting an attenuation in a signal from an analyte sensor after positioning during a predetermined time period, categorizing the detected attenuation in the analyte sensor signal based, at least in part, on one or more characteristics of the signal, performing signal processing to generate a reportable data associated with the detected analyte sensor signal during the predetermined time period, managing if and when to request additional reference signal measurements, and managing if and when to temporarily not display results. 1. A method of configuring a glucose monitoring system to detect early signal attenuation , the method comprising:programming a processor of an in vivo glucose monitoring system to:monitor for glucose signal from an analyte sensor positioned in fluid contact with interstitial fluid level below a predetermined threshold during a period of time immediately following sensor positioning, andreport glucose level associated with the glucose sensor only when the signal level monitored is not detected during the predefined time period.2. The method of claim 1 , wherein the predefined time period is within one day of sensor positioning.3. The method of claim 2 , wherein the predefined time period is within one hour of sensor positioning.4. The method of claim 1 , further comprising programming the processor to request a reference measurement when the signal is not detected.5. The method of claim 1 , wherein the predetermined threshold is predefined signal attenuation level.6. The method of claim 1 , wherein further comprising programming the processor not to report glucose level when the signal level monitored is detected during the predetermined time period.7. An in vivo glucose monitoring system comprising:an in vivo glucose sensor configured for in vivo positioning at least a portion of the sensor in ...

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09-05-2013 дата публикации

DETACHABLE BIOLOGICAL SIGNAL MEASURING PAD AND BIOLOGICAL SIGNAL MEASURING APPARATUS USING THE SAME

Номер: US20130116534A1
Автор: Woo Sung Hun
Принадлежит: UMEDIX CORPORATION LIMITED

Disclosed is a detachable biological signal measuring pad that may conveniently measure biological signals such as a pulse or body temperature. The biological signal measuring pad includes an adhesive pad main body detachably adhered to a body, a biological signal detecting electrode provided on an adhesive surface of the main body adhered to the body, and a module chip including a memory card mounted on the main body so as to be connected with the electrode and storing biological signals measured in the electrode, and provided on a surface opposite to the adhesive surface. 1. A detachable biological signal measuring pad , comprising:an adhesive pad main body detachably adhering to a human body;a biological signal detecting electrode provided on an adhesive surface of the main body adhering to the human body; anda module chip including a memory card mounted on the main body so as to be connected with the electrode, and storing biological signals measured in the electrode, and provided on a surface opposite to the adhesive surface.2. The detachable biological signal measuring pad of claim 1 , further comprising:a connecting pad provided between the electrode of the main body and the module chip, and having a connecting means for electrically connecting the module chip and the electrode,wherein the connecting means includes a connecting pin protruding from the module chip, and a plug groove connected with the electrode and formed on the connecting pad so as to receive the connecting pin.3. The detachable biological signal measuring pad of claim 2 , wherein the connecting means further includes adhesive members provided below the module chip and above the connecting pad so as to be coupled to each other.4. The detachable biological signal measuring pad of claim 1 , wherein the memory card is detachably coupled to the module chip.5. The detachable biological signal measuring pad of claim 4 , wherein the memory card includes a memory unit for storing the measured ...

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16-05-2013 дата публикации

BLOOD SAMPLING DEVICE

Номер: US20130121897A1
Принадлежит: BECTON, DICKINSON AND COMPANY

A blood sampling device useful for collecting a blood sample from a separate vascular access device is described herein. The blood sampling device includes a body shaped and sized for partial insertion into a separate vascular access device. The body includes a reservoir defined within the body, which has an internal volume sufficient to contain enough blood for use in a diagnostic blood test. The body also includes a gas permeable vent disposed on the body, in which the gas permeable vent is in gaseous communication with the reservoir. When connected to a separate vascular access device the blood sampling device collects a blood sample as blood flows into the reservoir from the separate vascular access device and as gases pass out the reservoir via the gas permeable vent. 1. A blood sampling device , comprising:a body shaped and sized for partial insertion into a separate vascular access device;a reservoir of one or more chambers, defined within the body, the reservoir having an internal volume sufficient to contain enough blood for use in a diagnostic blood test; anda gas permeable vent disposed on the body, the gas vent in gaseous communication with the reservoir.2. The blood sampling device of claim 1 , further comprising a diagnostic reagent disposed within at least one chamber of the reservoir.3. The blood sampling device of claim 1 , further comprising an on-board diagnostic cartridge in fluid communication with at least one chamber of the reservoir.4. The blood sampling device of claim 1 , the body comprising a compressible portion that is shaped and sized to eject the contents from at least one chamber of the reservoir when compressed.5. The blood sampling device of claim 1 , wherein the reservoir includes at least two chambers.6. The blood sampling device of claim 1 , wherein the reservoir includes a blood preservative in at least one chamber.7. The blood sampling device of claim 1 , wherein the body includes an indicator of elapsed time since blood ...

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16-05-2013 дата публикации

Constituent Concentration Measuring Apparatus and Constituent Concentration Measuring Apparatus Controlling Method

Номер: US20130123590A1

An object of the present invention is to provide a noninvasive constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method, in which accurate measurement can be performed by superimposing two photoacoustic signals having the same frequency and reverse phases to nullify the effect from the other constituent occupying large part of the object to be measured. The constituent concentration measuring apparatus according to the invention includes light generating means for generating two light beams having different wavelengths, modulation means for electrically intensity-modulating each of the two light beams having different wavelengths using signals having the same frequency and reverse phases, light outgoing means for outputting the two intensity-modulated light beams having different wavelengths toward a test subject, and acoustic wave detection means for detecting an acoustic wave generated in the test subject by the outputted light. 1175-. (canceled)176. A constituent concentration measuring apparatus characterized by comprising:light generating means for generating light;frequency sweep means for sweeping a modulation frequency, the light generated by said light generating means being modulated in the modulation frequency;light modulation means for electrically intensity-modulating the light using a signal from said frequency sweep means, the light being generated by said light generating means;light outgoing means for outputting said intensity-modulated light toward an object to be measured;acoustic wave detection means for detecting an acoustic wave which is generated in the object to be measured by said outputted light; andintegration means for integrating the acoustic wave in a swept modulation frequency range, the acoustic wave being detected by said acoustic wave detection means.177. A constituent concentration measuring apparatus as claimed in claim 176 , characterized in thatsaid acoustic wave ...

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16-05-2013 дата публикации

Constituent Concentration Measuring Apparatus and Constituent Concentration Measuring Apparatus Controlling Method

Номер: US20130123591A1

An object of the present invention is to provide a noninvasive constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method, in which accurate measurement can be performed by superimposing two photoacoustic signals having the same frequency and reverse phases to nullify the effect from the other constituent occupying large part of the object to be measured. The constituent concentration measuring apparatus according to the invention includes light generating means for generating two light beams having different wavelengths, modulation means for electrically intensity-modulating each of the two light beams having different wavelengths using signals having the same frequency and reverse phases, light outgoing means for outputting the two intensity-modulated light beams having different wavelengths toward a test subject, and acoustic wave detection means for detecting an acoustic wave generated in the test subject by the outputted light. 1175-. (canceled)176. A constituent concentration measuring apparatus characterized by comprising:light generating means for generating light;light modulation means for electrically intensity-modulating the light at a constant frequency, the light being generated by the light generating means;light outgoing means for outputting the intensity modulated light toward an object to be measured, the intensity modulated light being intensity-modulated by the light modulation means;an acoustic wave generator which outputs an acoustic wave; andacoustic wave detection means for detecting the acoustic wave emitted from the object to be measured, which is irradiated with said intensity modulated light, and said acoustic wave transmitted from said acoustic wave generator through the object to be measured.177. A constituent concentration measuring apparatus as claimed in claim 176 , characterized by further comprising drive means for varying at least one of positions of said acoustic wave ...

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16-05-2013 дата публикации

Systems and methods for determining physiological parameters using measured analyte values

Номер: US20130123592A1
Автор: Peter Rule
Принадлежит: Optiscan Biomedical Corp

Systems and methods for determining a physiological parameter in a patient are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a fluid sample received from a patient, a medical sensor configured to measure second analyte data in the patient, and a processor configured to receive the first analyte data and the second analyte data and to determine a physiological parameter based at least in part on the first analyte data and the second analyte data. In certain such embodiments, the medical sensor may be a pulse oximeter, and the physiological parameter may include a cardiovascular parameter including, for example, cardiac output.

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16-05-2013 дата публикации

Electrochemical Sensor

Номер: US20130123594A1
Автор: Tsukada Masashi
Принадлежит: ARKRAY, INC.

Depletion of an analyte on a surface of an electrode is restrained by increasing a quantity of supply of the analyte to the surface of the electrode. An electrochemical sensor includes a substrate, an electrode provided on the substrate, an external layer film provided on the substrate to cover the electrode, and a groove formed in at least a part of the substrate in a direction of the electrode of the substrate. 1. An electrochemical sensor comprising:a substrate;an electrode to be provided on the substrate;an external layer film to be provided on the substrate so as to cover the electrode; anda groove to be formed in at least a part of the substrate in a direction of the electrode of the substrate.2. The electrochemical sensor according to claim 1 , wherein the electrode is provided on the substrate so that at least the part of the electrode is positioned upwardly of the groove.3. The electrochemical sensor according to claim 1 , wherein the electrode is provided claim 1 , on the substrate claim 1 , adjacent to the groove.4. The electrochemical sensor according to claim 1 , wherein the substrate is formed with a plurality of grooves.5. The electrochemical sensor according to claim 1 , wherein a plurality of electrodes is provided on the substrate.6. The electrochemical sensor according to claim 1 , wherein the groove is formed in a concave shape.7. The electrochemical sensor according to claim 1 , wherein the groove is formed in a way that extends from an end portion of the substrate toward the direction of the electrode of the substrate.8. The electrochemical sensor according to claim 4 , wherein at least two lines of grooves in the plurality of grooves are connected to each other.9. The electrochemical sensor according to claim 1 , wherein the electrochemical sensor is used in the way of being subcutaneously indwelled.10. An electrochemical sensor comprising:a substrate;an electrode:a groove to be formed in at least a part of the substrate; andan external layer ...

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16-05-2013 дата публикации

ANALYTE SENSOR

Номер: US20130123596A1
Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 119-. (canceled)20. A method for processing continuous analyte sensor data , the method comprising:placing a continuous analyte sensor in fluid communication with a circulatory system of a host, wherein a sensor system comprises the sensor and sensor electronics, wherein the sensor is configured to generate a signal associated with an in vivo analyte concentration when the sensor is implanted in the host,exposing the sensor to a sample from the host's circulatory system;providing a fail-safe module comprising a processor for executing computer program code stored in memory to cause the processor to:perform a steady state analysis and a transient analysis of the signal;evaluate a relationship between the steady state analysis and the transient analysis; anddetect a malfunction of the system.21. The method of claim 20 , further comprising generating a signal associated with glucose.22. The method of claim 20 , wherein the detecting step further comprises detecting an electrical malfunction.23. The method of claim 20 , wherein the detecting step further comprises detecting a fluidics malfunction.24. The method of claim 20 , wherein the placing step further comprises inserting a vascular access device into the host's circulatory system.25. The method of claim 24 , wherein the placing step further comprises fluidly coupling the sensor to the vascular access device.26. The method of claim 20 , wherein the detecting step further comprises detecting a sensor malfunction.27. The method of claim 20 , wherein the detecting step further comprises performing a waveform analysis of the signal.28. The method of claim 20 , wherein the detecting step further ...

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16-05-2013 дата публикации

Lancing device with cam-actuated drive and separate guidance

Номер: US20130123824A1
Автор: Douglas A. Vine
Принадлежит: Facet Technologies LLC

A lancet assembly comprises a housing and a needle carriage movably housed within the housing, the needle carriage adapted to support a needle thereon, the needle carriage having a first end and a second end generally opposite thereto. A needle is mounted to the needle carriage and a guide element is positioned within the housing for guiding the needle carriage for reciprocating translation. A pivotal drive cam is provided for driving the needle carriage in translation and has a cam lobe for engaging the second end of the needle carriage, wherein the needle carriage is guided by the guide element and driven in translation by the pivotal drive cam such that the guidance and drive are kept separate. The pivotal drive cam can be moved between a cocked, retracted position, a fired, retracted position, and an extended position in between the cocked retracted position and the fired, retracted position. The lancet assembly can include a guidance biasing spring for biasing the needle carriage toward a retracted position and a separate drive spring for storing potential energy for pivoting the pivotal drive cam.

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23-05-2013 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20130131478A1
Принадлежит: DexCom, Inc.

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 1. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; anda membrane covering at least a portion of the electrode, wherein the membrane is configured to reduce passage of an interfering species therethrough, whereby the non-glucose-related component of the signal is less than about 20% of the signal over a period of at least one day;wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.2. The glucose sensor of claim 1 , wherein the interfering species has an oxidation potential that overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.3. The glucose sensor of claim 1 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.4. The glucose sensor of claim 1 , wherein the membrane comprises a silicone-containing polymer.5. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polysiloxanes.6. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polycarbosiloxane.7. The glucose sensor of wherein the silicone-containing polymer is a copolymer comprising a silicone segment and a polyurethane segment.8. The glucose sensor of claim 1 , wherein the membrane comprises a fluorocarbon-based material.9. The glucose sensor of claim 1 , wherein the non-glucose-related component ...

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23-05-2013 дата публикации

Diagnostic system

Номер: US20130131479A1
Принадлежит: Individual

A composite diagnostic system comprising a support member having a membrane penetration element; a bodily fluid collection point positioned for collection of a bodily fluid released by application of the membrane penetration element to a user's body; a test material positioned in the support member such that in use the bodily fluid is brought into contact with the test material.

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23-05-2013 дата публикации

Body fluid testing device

Номер: US20130131480A1
Принадлежит: Roche Diagnostics Operations Inc

Body fluid testing device for analyzing a body fluid comprises a test media tape adapted to collect the body fluid. The test media tape comprises a tape and test media portions. A free tape portion without test medium is located between successive test media portions. The testing device further comprises a supply portion. The supply portion comprises a housing in which uncontaminated test media tape is contained. The housing further has an opening for withdrawing test media tape from the housing. The testing device further has a sealing means for closing the opening against the surrounding. A free tape portion of the test media tape is located between a wall of the housing and the sealing means when the sealing means closes the opening. Further aspects concern a test media cassette with sealing means and a method for providing test media while holding them sealed against humidity during onboard storage.

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30-05-2013 дата публикации

METHOD AND SYSTEM TO DISPLAY ANALYTE SENSOR DATA

Номер: US20130137952A1
Принадлежит: Animas Corporation

Described and illustrated herein are an exemplary methods and system to display analyte sensor data. Such method may be achieved by the medical device receiving data from the analyte sensor for a period of time and displaying a target zone and a graphical representation of the data in which one or more portions of the graphical representation comprises a specific indicia of clinical risk. 1. A method of monitoring analyte concentrations of a user over time , the method comprising:determining with an analyte sensor that transforms signals of analyte concentrations in physiological fluid of the user over a period of time into determined analyte concentration data; anddisplaying a target zone of upper and lower analyte concentration thresholds, a first indicia representative of the determined analyte concentration data in the target zone, and a second indicia representative of the determined analyte concentration data outside of the target zone.2. The method of claim 1 , in which the displaying further comprises displaying a third indicia for at least one analyte concentration of the determined analyte concentration data below the target zone.3. The method of claim 1 , in which the target zone comprises a threshold value indicative of clinical risks arising from diabetes.4. The method of claim 2 , in which each of the first claim 2 , second and third indices comprises respective symbols.5. The method of claim 2 , in which each of the indices further comprises a color.6. The method of claim 1 , in which each of the indices comprises an icon.7. The method of claim 1 , in which the analyte sensor comprises a continuous glucose sensor.8. The method of claim 1 , in which the displaying comprises displaying a trend indicative symbol to represent a trend of determined analyte concentration data over a predetermined time frame.9. A system for diabetes management claim 1 , the system comprising:an analyte sensor configured to transmit data transformed from a user's signals ...

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30-05-2013 дата публикации

ANALYTE MONITORING SYSTEM AND METHODS OF USE

Номер: US20130137953A1
Принадлежит: ABBOTT DIABETES CARE INC.

The present disclosure provides methods of processing data provided by a transcutaneous or subcutaneous analyte sensor utilizing different algorithms to strike a balance between signal responsiveness accompanied by signal noise and the introduction of error associated with that noise. The methods utilize the strengths of a lag correction algorithm and a smoothing algorithm to optimize the quality and value of the resulting data (glucose concentrations and the rates of change in glucose concentrations) to a continuous glucose monitoring system. Also provided are systems and kits. 1. A method for monitoring an analyte , comprising:monitoring a data stream including a set of contiguous source data points related to the concentration of an analyte;providing one or more sets of maximum lag corrected signals from the one or more sets of monitored data stream, wherein each set of maximum lag corrected signals is generated utilizing correction terms based on time derivative estimates and historical monitored data stream, and wherein parameters for the maximum lag correction minimize the correlation between the expected glucose error and time derivative estimates and minimize the correlation between the expected glucose error and a pre-determined array of historical monitored data stream;providing one or more sets of maximum smoothing signals from the set of monitored data stream, wherein each set of maximum smoothing signals is generated utilizing a smoothing algorithm;determining analyte concentration utilizing the one or more sets of maximum lag corrected signals; anddetermining a rate of change in the analyte concentration utilizing the one or more sets of maximum smoothing signals.2. The method of claim 1 , wherein providing the one or more sets of maximum lag corrected signals includes utilizing an aggressive lag correction algorithm claim 1 , the lag correction algorithm configured to drive one or more of the correlation between the expected glucose error and the time ...

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30-05-2013 дата публикации

Delivering and/or receiving fluids

Номер: US20130138058A9
Принадлежит: Seventh Sense Biosystems Inc

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

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06-06-2013 дата публикации

Anti-Interferent Barrier Layers for Non-Invasive Transdermal Sampling and Analysis Device

Номер: US20130144142A1
Принадлежит: Flexible Medical Systems, LLC

A system and methods are provided for reducing electrochemical interference in a transdermal sampling and analysis device. A one-step transdermal glucose biosensor may calculate glucose concentrations that are artificially high compared to traditional home blood glucose sensors due to interference, which may be mitigated by forming an anti-interferent barrier layer over a sensing element. The anti-interferent barrier layer may be formed over a sensing layer and may possess a charge type which repels interferent molecules having the same charge type from interacting with the sensing layer disposed below the anti-interferent barrier layer. 1. A transdermal sampling and analysis device comprising:a substrate having a first side;at least one disruptor mounted on the first side of the substrate, wherein the at least one disruptor is configured to generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism;a reservoir configured to collect and contain a biological sample; and a surface of at least one of the sensing electrodes is coated with a sensing layer having a first charge type; and', 'the sensing layer is covered with an anti-interferent barrier layer having at least a second charge type, wherein the first charge type is an opposite charge type from the second charge type., 'a biological sensing element comprising at least two sensing electrodes configured, to determine levels of an analyte in the biological sample, wherein2. The transdermal sampling and analysis device of claim 1 , wherein the sensing layer comprises an enzyme claim 1 , an electron mediator claim 1 , and a polymer.3. The transdermal sampling and analysis device of claim 2 , wherein the biological sample is interstitial fluid (ISF) claim 2 , and wherein the enzyme is an oxidoreductase.4. The transdermal sampling and analysis device of claim 3 , wherein the oxidoreductase is glucose oxidase (GOx).5. The transdermal sampling and ...

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06-06-2013 дата публикации

DEVICE SYSTEM AND METHOD FOR MONITORING AND CONTROLLING BLOOD ANALYTE LEVELS

Номер: US20130144144A1
Принадлежит: C.G.M.3 LTD.

Systems, devices, and methods for monitoring an analyte in a subject. The systems, devices, and methods may include a sensor element being designed and configured for detecting said analyte in blood flowing through a bone of the subject, and a fixation element that is capable of fixating said sensor element within the bone tissue 1. A system for monitoring an analyte in a subject comprising a sensor element being designed and configured for detecting said analyte in blood flowing through a bone of the subject , and a fixation element that is capable of fixating said sensor element within the bone tissue.2. A system for monitoring an analyte in a subject comprising a sensor element being designed and configured for detecting said analyte in blood flowing through a bone of the subject , and a rigid implant-protecting and stabilizing device comprising an elongate body perforated by a longitudinally-disposed central bore , wherein said device is of a size and shape such that it is capable of completely or partially containing said sensor element within its central bore.3. A device for monitoring an analyte in a subject comprising a sensor element being designed and configured for detecting the analyte in blood flowing through a bone of the subject.4. The device of claim 3 , wherein the device is completely implanted within tissue of the subject.5. The device of claim 4 , wherein said sensor element is implanted within bone tissue and is designed and configured for contacting blood flowing within a blood sinus of said bone tissue.6. The device of claim 3 , wherein said sensor element is anchored to bone tissue.7. The device of claim 3 , further comprising a wireless communication unit for remotely communicating with a wireless control unit.8. The device of claim 3 , further comprising circuitry for remotely powering said sensor element.9. The device of claim 3 , wherein said analyte is glucose.10. A system for monitoring an analyte in a subject comprising a device ...

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13-06-2013 дата публикации

Analyte Sensor Devices, Connections, and Methods

Номер: US20130150691A1
Принадлежит: ABBOTT DIABETES CARE INC.

Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together. 1. An apparatus comprising:a first assembly including a portion of an on-body device;a second assembly coupleable to the first assembly to form the on-body device and a sharp supporting a sensor of the on-body device;an applicator assembly releasably coupled to the first assembly; anda container releasably coupled to the second assembly,wherein in response to force applied to the applicator assembly along a longitudinal axis that drives the applicator assembly into the container, the applicator assembly releases and retrieves the second assembly from the container and couples the first assembly to the second assembly to form the on-body device releasably held within the applicator assembly, andwherein the on-body device once held within the applicator assembly is ready to be applied.2. The apparatus of wherein in response to a force applied to the applicator assembly along the longitudinal axis with the applicator assembly loaded with the on-body device and held against a user claim 1 , the applicator assembly collapses along the longitudinal axis claim 1 , drives the sharp supporting the sensor of the on-body device through skin of the user in a direction along the longitudinal axis claim 1 , releases the on-body device from the applicator assembly upon the applicator assembly reaching a fully collapsed position claim 1 , adheres the on-body device to the skin of the user claim 1 , and retracts ...

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13-06-2013 дата публикации

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

Номер: US20130150692A1
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided. 1. A method for generating analyte measurements of a host , the method comprising:generating sensor data during a first time period using an analyte sensor coupled to a sensor electronics unit, wherein the sensor electronics unit is adhered to a body of a host;receiving, using a receiver in wireless communication with the sensor electronics unit, a reference analyte value generated by a reference analyte monitor;responsive to receiving the reference analyte value, determining a first estimated analyte concentration value to display using a first algorithm, wherein determining the first estimated analyte concentration to display includes using the reference analyte value in a first algorithm;determining a second estimated analyte concentration value to display using the reference analyte value and the sensor data for the first time period in a second algorithm that is different from the first algorithm; anddisplaying, on a display of the receiver, a numerical analyte value selected from the first estimated analyte value and the second estimated analyte value, wherein the first estimated analyte concentration value is selected as the displayed numerical value until the second estimated analyte concentration is available, and subsequently selecting the second estimated analyte concentration value to be the displayed numerical value.2. The method of claim 1 , wherein the sensor data for the first time period is not used ...

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20-06-2013 дата публикации

SYSTEM FOR MONITORING AND MANAGING BODY WEIGHT AND OTHER PHYSIOLOGICAL CONDITIONS INCLUDING ITERATIVE AND PERSONALIZED PLANNING, INTERVENTION AND REPORTING CAPABILITY

Номер: US20130158367A1
Принадлежит: BodyMedia, Inc.

A nutrition and activity management system is disclosed that monitors energy expenditure of an individual through the use of a body-mounted sensing apparatus. The apparatus is particularly adapted for continuous wear. The system is also adaptable or applicable to measuring a number of other physiological parameters and reporting the same and derivations of such parameters. A weight management embodiment is directed to achieving an optimum or preselected energy balance between calories consumed and energy expended by the user. An adaptable computerized nutritional tracking system is utilized to obtain data regarding food consumed, Relevant and predictive feedback is provided to the user regarding the mutual effect of the user's energy expenditure, food consumption and other measured or derived or manually input physiological contextual parameters upon progress toward said goal. 1278.-. (canceled)279. A system for monitoring human physiological parameters and providing status information therefor , the system comprising: an apparatus adapted for placement on the human body which: (a) receives at least one of (i) detected and (ii) manually input data related to a first human physiological parameter; (b) directly detecting at least a second human physiological parameter; and (c) providing status information with respect to the mutual effect of changes of said first and second human physiological parameters upon each other.280. A system as described in claim 279 , wherein said apparatus is a sensor device for mounting on the human body.281. A system as described in claim 280 , wherein said sensor device is an armband sensor device for mounting on the upper arm of the human body.282. A system as described in claim 280 , wherein said sensor device further comprises at least one sensor for detecting at least one of said first and second human physiological parameters.283. A system as described in claim 280 , wherein said at least one sensor further comprises at least one of ...

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20-06-2013 дата публикации

Activity Monitoring Systems and Methods of Operating Same

Номер: US20130158369A1
Принадлежит: Fitbit, Inc.

The present inventions, in one aspect, is an activity monitoring system comprising a fixture having size/shape adapted to couple to a location on the user's body and a particular signature; and a portable monitoring device adapted to detect the fixture's particular signature. The monitoring device includes a housing that is adapted to engage the fixture; an activity sensor, disposed in the housing, to detect activity of the user and to generate data which is representative of the activity of the user; and processing circuitry, disposed in the housing, to calculate an activity-related quantity of the user, wherein the processing circuitry determines the monitoring device is engaging the fixture by detecting the fixture's particular signature and calculates the activity-related quantity. 1. An activity monitoring system comprising:a plurality of fixtures, wherein each fixture includes a physical size and shape that is adapted to couple to an associated location on the body of the user; a housing to separately and physically engage each fixture;', 'an activity sensor, disposed in the housing, to detect activity of the user and, in response thereto, to generate data which is representative of the activity of the user; and', automatically determines a particular fixture of the plurality of fixtures is physically engaging the portable monitoring device, and', 'calculates at least one activity-related quantity of the user which is associated with the particular fixture., 'processing circuitry, disposed in the housing and coupled to the activity sensor, to calculate one or more activity-related quantities of the user using the data which is representative of the activity of the user, wherein the processing circuitry], 'a portable monitoring device adapted to separately and physically engage each fixture of the plurality of fixtures, the portable monitoring device including2. The activity monitoring system of wherein:at least one fixture of the plurality of fixtures includes ...

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20-06-2013 дата публикации

SYSTEM FOR WITHDRAWING SMALL AMOUNTS OF BODY FLUID

Номер: US20130158373A1
Принадлежит: ROCHE DIAGNOSTICS OPERATIONS, INC.

A system is provided for withdrawing small amounts of body fluid from an animal or human. The system includes a holder and a disposable lancing unit attached to the holder. The lancing unit also includes an open capillary channel for transporting the body fluid and piercing the skin. 1. A system , comprising:a disposable lancing unit having a needle with a distal end for piercing a surface of skin, wherein the needle has at least one capillary structure that is open to the outside from at least the distal end to at least an upper end of the needle; anda drive unit configured to hold the distal end of the needle below the surface of the skin and the upper end above the surface of the skin during fluid collection.2. The system of claim 1 , in which the disposable lancing unit has a holding area.3. The system of claim 2 , in which the holding area has a detection zone for detecting one or several analytes claim 2 , the detection zone being arranged for taking up body fluid from the capillary structure.4. The system of claim 3 , wherein the detection zone includes a reagent for detecting the analytes in the body fluid.5. The system of claim 2 , in which the capillary structure and holding area are integrally connected together.6. The system of claim 2 , in which the holding area and capillary structure are integrally manufactured from a single piece of material.7. The system of claim 2 , in which the holding area and capillary structure are manufactured from a semiconductor.8. The system of claim 1 , wherein the drive unit is configured to partially retract the lancing unit in the skin so that the capillary structure remains in part in the skin to promote pooling of body fluid.9. The system of claim 1 , in which the length of the capillary structure is in the range from 0.3 to 3 mm and the cross-section of the capillary structure is in the range from 0.03 to 0.8 mm.10. The system of claim 1 , wherein:the capillary structure has an aspect ratio from 2 to 5; andthe ...

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20-06-2013 дата публикации

Temperature-Compensated Analyte Monitoring Devices, Systems, and Methods Thereof

Номер: US20130158376A1
Принадлежит:

Methods, devices and systems related providing accurate glucose levels in view of temperatures that may adversely affect glucose value. 1. A method of determining an analyte level by compensating for ambient temperature using a single temperature sensor , the method comprising:receiving a sensor signal derived from an in vivo analyte sensor;detecting a temperature measurement from a temperature sensor;determining, with a processor, whether a threshold requirement is exceeded based on the temperature measurement; anddetermining, with the processor, a temperature-compensated analyte sensor signal;wherein when the threshold requirement is not exceeded, the temperature-compensated analyte sensor signal is determined using the temperature measurement; andwherein only when the threshold requirement is exceeded, the temperature-compensated analyte sensor signal is determined using an ambient-compensated temperature that is derived by compensating the temperature measurement for ambient temperature.2. The method of claim 1 , wherein the ambient-compensated temperature is derived by adding a correction factor to the temperature measurement.3. The method of claim 1 , wherein the analyte is glucose.4. The method of claim 1 , wherein the threshold requirement is exceeded when a value of the temperature measurement exceeds the threshold requirement.5. The method of claim 1 , wherein the threshold requirement is exceeded when a rate-of-change of the temperature measurement exceeds the threshold requirement.6. An analyte monitoring device claim 1 , comprising:a housing;a processor coupled to the housing;wherein an in vivo analyte sensor is communicably coupled to the processor;wherein a temperature sensor is communicably coupled to the processor; and receive a sensor signal from the in vivo analyte sensor;', 'detect a temperature measurement from the temperature sensor;', 'determine whether a threshold requirement is exceeded based on the temperature measurement; and', 'determine ...

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20-06-2013 дата публикации

Drug Delivery and Substance Transfer Facilitated by Nano-Enhanced Device Having Aligned Carbon Nanotubes Protruding from Device Surface

Номер: US20130158377A1
Принадлежит: California Institute of Technology

The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc. 1. A nano-enhanced device for substance transfer between the device and a tissue , comprising:a substrate; andan array of substantially aligned carbon nanotubes having two ends, the carbon nanotubes being anchored within the substrate with at least one end protruding from the substrate, whereby the protruding carbon nanotubes enhance the substance transfer capabilities of the device.2. The device of claim 1 , wherein the carbon nanotube array is coated with a substance selected from the group consisting of a drug and a gene.3. The device of claim 2 , wherein the carbon nanotubes have side walls and where the nanotube array contains free spaces between the carbon nanotubes claim 2 , and where the protruding ends of the anchored carbon nanotubes are free of coated substance and the substance coating area consists of an area selected from the group consisting of side walls of the carbon nanotubes and free spaces between the carbon nanotubes.4. The device of claim 2 , wherein the device is selected from the group consisting of a patch to be worn on the tissue and an angioplasty balloon.5. The device of claim 4 , wherein the drug is paclitaxel.6. The device of claim 2 , wherein delivery of the drug ...

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20-06-2013 дата публикации

AUTONOMOUS, AMBULATORY ANALYTE MONITOR OR DRUG DELIVERY DEVICE

Номер: US20130158430A1
Принадлежит: Intuity Medical, Inc.

The invention relates to analyte monitoring/drug delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The invention can optionally provide for calibration without intervention of the user and can also provide for semi-continuous monitoring for day and night time. The invention can provide up to four, or more, weeks of operation. The invention can provide for a device that is relatively small in size, and therefore unobtrusive. The invention can also provide for device with remote control and interactive electronics. The invention may be also used for the delivery of various pharmaceutical agents. 159-. (canceled)60. An analyte monitoring device operable to draw a fluid sample from a subject , the device comprising:a plurality of microneedles disposed on a carrier,a plurality of microchannels, wherein each of the plurality of microneedles is at least intermittently in fluid communication with a corresponding microchannel, wherein each of the plurality of microneedles is connected to and moveable with a corresponding fluidic capture site and is constructed and arranged to collect the fluid sample from the subject, wherein the corresponding fluidic capture site is configured to fluidly couple to and deliver the fluid sample to at least one of the plurality of microchannels, and wherein each microchannel is associated with a reagent,at least one actuator operable to extend each microneedle and corresponding fluidic capture site to collect the fluid sample from the subject and to deliver the fluid sample to the at least one of the plurality of microchannels, anda controller operable to ...

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20-06-2013 дата публикации

Delivering and/or receiving material with respect to a subject surface

Номер: US20130158468A1
Принадлежит: Seventh Sense Biosystems Inc

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. The flow activator may be actuated in a deployment direction by a deployment actuator, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, an effector may enable fluid communication between the opening and the vacuum source and may do so in response to actuation of the flow activator.

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27-06-2013 дата публикации

Fluid injection and safety system

Номер: US20130160532A1
Принадлежит: Optiscan Biomedical Corp

Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port.

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27-06-2013 дата публикации

ACOUSTIC WARNING LEVEL OPTIMIZATION IN AMBULATORY MEDICAL SYSTEMS

Номер: US20130163769A1
Автор: Kalt Lucas, Remde Axel
Принадлежит: ROCHE DIAGNOSTICS INTERNATIONAL AG

An ambulatory medical device is presented. The ambulatory medical device comprises a function module to provide the intended functionality of the device, a controller module to control the device, a sound generation module with an acoustic transducer to produce an acoustic signal and a signal generator to drive the acoustic transducer with a certain frequency. The signal generation module is arranged within a housing of the device. A tuning module varies the frequency used by the signal generator to drive the acoustic transducer and determines one or more frequencies that correspond to an optimum sound level of the acoustic signal outside of the housing of the device. The optimum sound level of the acoustic signal is a maximum sound level outside of the housing of the device, and/or a maximum perceivable sound level as determined by a user. 1. An ambulatory medical device , the ambulatory medical device comprising:a function module to provide the intended functionality of the device;a controller module to control the device;a sound generation module with an acoustic transducer to produce an acoustic signal;a signal generator to drive the acoustic transducer with a certain frequency, wherein the signal generation module is arranged within a housing of the device; anda tuning module that varies the frequency used by the signal generator to drive the acoustic transducer and determines one or more frequencies that correspond to an optimum sound level of the acoustic signal, wherein the optimum sound level of the acoustic signal is a maximum sound level outside of the housing of the device and/or a maximum perceivable sound level as determined by a user.2. The device according to claim 1 , wherein the tuning module comprises one or more sensors for obtaining feedback data directly and/or indirectly related to the sound level of the acoustic signal outside of the housing.3. The device according to claim 1 , wherein the tuning module measures an electrical claim 1 , or ...

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04-07-2013 дата публикации

Emergency Medical Diagnosis and Communications Device

Номер: US20130172689A1
Принадлежит:

A portable emergency medical device capable of communicating with a remote location preferably as a cellular telephone that can measure one or more human vital parameters such as pulse rate, body temperature, skin moisture, blood pressure, ECG or blood chemistry and can receive symptoms from a user either by voice recognition or by keypad and can provide an expert medical diagnosis. The device can store a complete medical history for one or more users and can use an expert system to make the diagnosis. The device can make an emergency medical call either on command or automatically requesting help and optionally supplying medical information and/or GPS location information. 1. A personal medical diagnosis apparatus comprising:a cellular telephone module including a processor and memory;a medical expert system disposed in said memory and executable on said processor;a medical probe that measures at least one human medical parameter, said probe being in data communication with said medical expert system; andan input device, including a keyboard and circuitry through which the medical expert system receives symptom data;the expert system receiving imputed symptom data and at least one medical parameter and making a medical diagnosis.2. The personal medical diagnosis apparatus of further comprising a GPS receiver in communication with said processor claim 1 , wherein said processor is adopted to report a geographic location of said medical diagnosis apparatus to a remote station.3. The personal medical diagnosis apparatus of further comprising a housing wherein said medical probe is at least one of:a blood pressure sensor in or deployable from said housing;a pulse rate sensor in or deployable from said housing;a body temperature sensor in or deployable from said housing, or;an ECG interface in or deployable from said housing.4. The personal medical diagnosis apparatus of further comprising a housing wherein said medical probe is at least one of:a blood pressure sensor ...

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