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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 962. Отображено 100.
19-01-2012 дата публикации

Pharmaceutical composition container

Номер: US20120012480A1
Автор: Shuji Morimoto, Yutaka Sakuma
Принадлежит: Morimoto Pharma Co Ltd

It is possible to easily swallow a pharmaceutical composition and to suppress the scattering thereof inside the mouth; furthermore, the pharmaceutical composition can be filled in easily. The pharmaceutical composition container 10 is equipped with a plurality of spaces 30 and 32 . The portions 70 and 72 between two adjoining spaces are sealed. The portions 70 and 72 between two adjoining spaces open when force is applied from the outside of the pharmaceutical composition container 10 . A swallowing-aid substance 40 is stored in the swallowing-aid substance storage chamber 30 . An encapsulating item 42 is stored in the encapsulating-item storage chamber 32 . The encapsulating item 42 contains the pharmaceutical composition 80 . The sheet 20 is provided with a predetermined aperture part 60 . The predetermined aperture part 60 is a portion where an aperture is to be formed. The aperture interconnects the outside of the pharmaceutical composition container 10 with the spaces 30 and 32.

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Номер записи: 1
08-03-2012 дата публикации

Implantable drug delivery devices

Номер: US20120059349A1
Автор: Michael R. Violante, Youti Kuo
Принадлежит: Pharmanova Inc

The invention relates generally to implantable drug delivery devices. Devices having a single drug chamber configuration, a divided drug chamber configuration and a compact dual-drug configuration are described. The devices have features to prevent clogging of the dispensing catheter and the creation of a local vacuum caused by the dispensing of the drug fluid. Also provided are features of a failsafe refilling process, automatic refill notification, and performance verification process. The divided drug chamber configuration enables frequent or continuous minute doses. A dual-drug chamber configuration uses self-locking refill containers to prevent mismatching between refill containers and drug chambers.

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Номер записи: 2
21-03-2013 дата публикации

Coded Collapsible Drug Reservoir

Номер: US20130072878A1
Автор: Richard James Vincent Avery
Принадлежит: Sanofi Aventis Deutschland GmbH

A coded collapsible drug reservoir ( 200 ) and a drug delivery system ( 100 ) including a coded collapsible drug reservoir ( 200 ). The drug reservoir ( 200 ) includes a collapsible housing ( 202 ) and a port ( 204 ) in communication with the collapsible housing ( 202 ). The drug reservoir ( 200 ) further includes a coding feature ( 206 ) disposed on the drug reservoir ( 200 ), and the coding feature ( 206 ) identifies the drug reservoir ( 200 ).

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Номер записи: 3
16-05-2013 дата публикации

Fluid dispenser with tongue depressor

Номер: US20130123690A1
Автор: Don F. Yeager
Принадлежит: Amcor Pty Ltd

A fluid dispenser contains a fluid and selectively delivers the fluid orally to a subject. The fluid dispenser includes a main body defining a vessel that contains the fluid. The fluid dispenser also includes a dispensing portion that extends from the main body. The dispensing portion defines a passage therethrough that is in fluid communication with the vessel. The passage terminates at a dispenser opening through which the fluid exits the passage and flows into the mouth of the subject. Moreover, the fluid dispenser includes a tongue depressor that extends from the dispensing portion. The tongue depressor is operable to depress the tongue of the subject while the fluid is dispensed into the mouth of the subject.

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Номер записи: 4
06-02-2014 дата публикации

Plastic Ampule

Номер: US20140039444A1
Автор: Samejima Yosuke, Togawa Akihito
Принадлежит:

A plastic ampule of the present invention is composed of a single layer of a plastic layer consisting only of a cyclic polyolefin with a glass transition temperature of 50° C. to 104° C.; integrally includes an ampule body formed in a bottle shape with a top part and a bottom part and having a bung for discharging a drug solution on the top part, a cap attached to the ampule body so as to seal the bung, and a thinner part having a layer thickness thinner than those of the ampule body and the cap, formed along a circumferential direction of the bung and connecting between the ampule body and the cap; and is opened by breaking off or twisting off the thinner part as a cutting part between the ampule body and the cap. 2. The plastic ampule according to claim 1 , wherein the layer thickness of the ampule body is 500 μm to 1200 μm.3. The plastic ampule according to claim 1 , wherein a content of the drug solution in the plastic ampule is 1 mL to 5 mL claim 1 , and a capacity of the ampule body for the drug solution is 1.5 mL to 7.5 mL.4. The plastic ampule according to claim 1 , wherein the thinner part is formed with a thickness that allows opening by breaking off the thinner part by a force of 70 N·m/mm or less.5. The plastic ampule according to claim 1 , wherein the thinner part is formed with a thickness that allows opening by twisting off the thinner part with a force of 0.900 N·m or less.6. The plastic ampule according to claim 1 , wherein the cap is a tab formed in a flat shape. The present invention relates to a plastic ampule made of a cyclic polyolefin storing a drug solution.Containers such as ampules for storing a drug solution have undergone recent changes from containers made of glass to those made of plastic (plastic ampule) in light of strength against impact, ease in handling, safety and the like.For example, a medical instrument made of a thermoplastic norbornene has been proposed (see Patent Document 1). In addition, a container for a sanitary ...

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Номер записи: 5
13-03-2014 дата публикации

Method for marking a small-volume single-dose container, and container thus marked

Номер: US20140069839A1
Автор: Patrick Colin
Принадлежит: UNITHER PHARMACEUTICALS

A method for marking a vial made from a material that is transparent or at least translucent, intended, in particular, for pharmaceutical and/or cosmetic use. The container includes a foot ( 12 ), a body ( 14 ) and a head ( 16 ), the foot taking the form of a tongue having two faces, one of which receives a label ( 32 ). The container is characterized in that a mark ( 30 ) is made on the face of the foot ( 12 ) that receives the label, prior to the affixing of the label, and in that the label is affixed to the face once the mark has been made, such that the label covers the mark.

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Номер записи: 6
07-01-2021 дата публикации

DRUG-FILLED SYNTHETIC RESIN AMPULE AND SYNTHETIC RESIN AMPULE BODY USED FOR SAME

Номер: US20210000689A1
Автор: CHIBA Akira, HARADA Naomi, MASUDA Taeko, YAMAGAMI Masahide
Принадлежит: TERUMO KABUSHIKI KAISHA

A drug-filled synthetic resin ampule includes an ampule body and a drug filled in the ampule body. The ampule body includes a tip-side sealing portion, a hollow portion, and an annular breakable portion provided between the tip-side sealing portion and the hollow portion. The tip-side sealing portion includes a flat plate portion for grasping formed at an upper portion thereof, and an internal ceiling portion exposed to the interior of the hollow portion. The breakable portion includes an annular smallest diameter portion, and the smallest diameter portion is located near an annular circumferential edge portion of the internal ceiling portion and is located above the annular circumferential edge portion of the internal ceiling portion. 1. A drug-filled synthetic resin ampule comprisinga hollow ampule body, a lower-end-side sealing member for sealing a lower end of the ampule body, and a drug filled in the ampule body;wherein the ampule body includes a tip-side sealing portion, a hollow portion located below the tip-side sealing portion and having a drug containing portion therein, and an annular breakable portion provided between a lower portion of the tip-side sealing portion and an upper portion of the hollow portion;the tip-side sealing portion includes a flat plate portion for grasping formed at an upper portion thereof and an internal ceiling portion exposed to an interior of the hollow portion; andthe breakable portion includes an annular smallest diameter portion which is located near an annular circumferential edge portion of the internal ceiling portion and is located above the annular circumferential edge portion of the internal ceiling portion.2. A drug-filled synthetic resin ampule according to claim 1 , wherein the annular smallest diameter portion is an annular smallest diameter portion formed to have an acute angle.3. A drug-filled synthetic resin ampule according to claim 1 , wherein an upper portion of the hollow portion gradually decreases in wall ...

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Номер записи: 7
07-01-2021 дата публикации

VIAL WITH OPTIMIZED NECK FOR IMPROVED SIDE COMPRESSION PERFORMANCE

Номер: US20210002016A1
Автор: Humbertjean Alexander, Kummer Hanspeter, Langsdorf Andreas, MAURER Florian, THOMAS Peter, Wetzel Tobias
Принадлежит: SCHOTT AG

A glass container is provided having a glass tube with a first end and a second end and a glass bottom closing the second end. The glass tube has a longitudinal axis and has, in a direction from the first to the second end, a top region, a junction region, a neck region, a shoulder region, and a body region. The top region is at the first end and has an outer diameter (d), the neck region has an outer diameter (d) with dd, and the glass tube in the body region has a thickness (l). The outer contour in a transition area between the top and neck regions is defined by a radius of curvature. The glass containers have a neck squeeze test load of at least 1100 N. 1. A glass container , comprising:{'sub': tube', 't', 'n', 'n', 't', 'b', 'b', 't', 'b, 'a glass tube with a first end, a second end, and a longitudinal axis Ltherebetween, the glass tube has, in a direction from the first end to the second end, a top region, a junction region, a neck region, a shoulder region, and a body region, wherein the top region is at the first end and has an outer diameter (d), the neck region has an outer diameter (d) with dd, and the glass tube in the body region has a thickness (l); and'}a glass bottom closing the glass tube at the second end,{'sub': tube', 'tube, 'wherein, when an outer surface of the body region is placed on a plane horizontal substrate, within any given cross-section of the glass container that is located in a plane centrically located in the glass container and comprising the longitudinal axis L, f(x) defines a vertical distance between the plane horizontal substrate and the outer surface at a given position x and l(x) defines a thickness of the glass tube at a given position x, wherein the thickness of the glass tube l(x) is measured in a direction perpendicular to the longitudinal axis L,'}{'sup': 2 ...

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Номер записи: 8
12-01-2017 дата публикации

RESERVOIR FOR LIQUID MEDICAMENT

Номер: US20170007500A1
Автор: Auernhammer Daniel, Klein Isabel, Kühn Bernd, Mischo Horst, Schabbach Michael, Schepers Klaus, Wagner Daniel, Weiss Pierre
Принадлежит:

A reservoir for liquid medicament includes a first boundary portion and a second boundary portion forming at least one cavity to receive the medicament. The first boundary portion is flexible, while the second boundary portion is rigid. At least one of the first and second boundary portions is a transparent boundary portion covered by an opaque cover which is at least partially detachable from the transparent boundary portion. 115-. (canceled)16. A reservoir for a liquid medicament , the reservoir comprising: a second boundary portion forming at least one cavity to receive the medicament, wherein the first boundary portion is flexible,', {'b': 16', '26', '36', '46', '56, 'wherein the second boundary portion (; ; ; ; ) is rigid, and'}], 'a first boundary portion; and'}wherein at least one of the first or second boundary portions is a transparent boundary portion covered by an opaque cover which is at least partially detachable from the transparent boundary portion.17. The reservoir according to claim 16 , wherein the first boundary portion is stretchable.18. The reservoir according to claim 16 , wherein the first boundary portion is transparent.19. The reservoir according to claim 16 , wherein the second boundary portion is transparent.20. The reservoir according to claim 16 , wherein the first boundary portion is collapsible onto or into the second boundary portion.21. The reservoir according to claim 16 , wherein the cover and at least one of first or second boundary portions is impervious to gases and fluids.22. The reservoir according to claim 16 , wherein the cover exhibits a larger barrier against gaseous or liquid substances compared to the first boundary portion or compared to the second boundary portion.23. The reservoir according to claim 16 , wherein the cover is flexible.24. The reservoir according to claim 16 , wherein the cover is rigid.25. The reservoir according to claim 16 , wherein the cover is attached to an entire surface of the transparent ...

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Номер записи: 9
12-01-2017 дата публикации

COMPRESSIBLE RESERVOIR FOR LIQUID MEDICAMENT

Номер: US20170007767A1
Автор: Auernhammer Daniel, Mischo Horst, Schabbach Michael, Schepers Klaus, Wagner Daniel, Weiss Pierre
Принадлежит:

The present invention relates to a reservoir () for a liquid medicament (), comprising: a first boundary portion () and a second boundary portion () forming a cavity () to receive the medicament, wherein the first boundary portion is sub-stantially opaque and flexible, and wherein the second boundary portion is substantially transparent and rigid. 1. A reservoir for a liquid medicament , comprising:{'b': 16', '36', '46', '18', '38', '48', '12', '32', '42', '11, 'a first boundary portion (; ; ) and a second boundary portion (; ; ) forming a cavity (; ; ) to receive the medicament (),'}{'b': 16', '36', '46, 'wherein the first boundary portion (; ; ) is substantially opaque and flexible, and'}{'b': 18', '38', '48, 'wherein the second boundary portion (; ; ) is substantially transparent and rigid.'}2163646. The reservoir according to claim 1 , wherein the first boundary portion (; ; ) is stretchable.3183848. The reservoir according to any one of the preceding claims claim 1 , wherein the second boundary portion (; ; ) comprises at least one inflexible material.4163646183848. The reservoir according to any one of the preceding claims claim 1 , wherein the first boundary portion (; ; ) is substantially collapsible onto or into the second boundary portion (; ; ).5161836384648. The reservoir according to any one of the preceding claims claim 1 , wherein first and second boundary portions ( claim 1 , ; claim 1 , ; claim 1 , ) are impervious to gases and fluids.6143444123242161836384648. The reservoir according to any one of the preceding claims claim 1 , further comprising at least one outlet port (; ; ) in fluid connection with the cavity (; ; ) and intersecting at least one of first and second boundary portions ( claim 1 , ; claim 1 , ; claim 1 , ).7163646183848173747. The reservoir according to any one of the preceding claims claim 1 , wherein the first boundary portion (; ; ) and the second boundary portion (; ; ) are mutually connected or bonded along a ...

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Номер записи: 10
10-01-2019 дата публикации

Methods And Applicators With Twist Tab And Resilient Structure For Medical Liquid Application

Номер: US20190009068A1
Автор: Afarian Viken, Margoosian Razmik
Принадлежит:

An applicator can have an ampoule body for holding a medical liquid; a tab extending away from the ampoule body and being twistable or deflectable with respect to a longitudinal axis of the ampoule body; and a frangible region in between the tab and the distal portion of the ampoule body, the frangible region being breakable in response to twisting or deflection of the tab. The applicator can have a resilient structure extending between the tab and the ampoule body and configured to allow the twisting or deflection to enable breakage of the frangible region while remaining intact and providing axial rigidity in response to a deflection pressure exerted on the tab during application of the medical liquid. The applicator can have features such as a thumb rest, a bubble portions, a pyramidal body construction, an offset frangible nodule, and various tab and head constructions. 1. A medical liquid applicator , comprising:an ampoule body comprising a proximal portion and a distal portion, and having a wall defining a chamber for holding a medical liquid;a tab attached to and extending away from the distal portion of the ampoule body, the tab being twistable about or deflectable with respect to a longitudinal axis of the ampoule body;a frangible region in between the tab and the distal portion of the ampoule body, the frangible region being breakable in response to twisting or deflection of the tab to form an opening in fluid communication with the chamber to allow liquid communication out of the chamber into an absorbent material connectable to the tab; anda resilient structure extending between the tab and the ampoule body and configured to allow the twisting or deflection of the tab to enable breakage of the frangible region while remaining intact and providing axial rigidity to resist axial deflection of the tab in response to a deflection pressure exerted on the tab during application of the medical liquid.2107-. (canceled)108. The medical liquid applicator of claim ...

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Номер записи: 11
19-01-2017 дата публикации

REUSABLE CAP ASSEMBLY

Номер: US20170015476A1
Автор: McClellan Theresa
Принадлежит:

A cap assembly caps a sealed vial having a sealed flat top surface defining a top diameter and a side surface extending down therefrom. The cap assembly includes a cap top defining an outer surface and an inner surface. The cap top defines a cap diameter which is slightly larger than the top diameter. The cap top also defines a cap top periphery. A side rim extends out from the cap top about the cap top periphery to engage the side surface of the sealed vial. The side rim includes an inner surface. A pad is fixedly secured to the inner surface of the cap top. The pad is fabricated from an absorbent material, wherein the absorbent material is saturated with a liquid disinfectant to disinfect the sealed top surface when the cap assembly covers the sealed vial in a manner such that the pad contacts the sealed flat top surface. 1. A cap assembly for capping a sealed vial having a sealed flat top surface defining a top diameter and a side surface extending down therefrom , said cap assembly comprising:a cap top defining an outer surface and an inner surface, said cap top defining a cap diameter larger than the top diameter and a cap top periphery;a side rim extending out from said cap top about said cap top periphery to engage the side surface of the sealed vial, said side rim including an inner surface;a pad fixedly secured to said inner surface of said cap top, said pad being fabricated from an absorbent material, wherein said absorbent material is saturated with a liquid disinfectant to disinfect the sealed flat top surface when said cap assembly covers the sealed vial in a manner such that said pad contacts the sealed flat top surface.2. A cap assembly as set forth in including a handle extending out from said outer surface of said cap top.3. A cap assembly as set forth in wherein said side rim includes a retainer for positively engaging the side surface of the sealed vial.4. A cap assembly as set forth in wherein said retainer is a ridge extending around said inner ...

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Номер записи: 12
10-02-2022 дата публикации

CONTAINER

Номер: US20220041317A1
Автор: BOJBIC Daniel, HAMMER Alexander, KENGETER Oliver
Принадлежит:

A container, in particular in ampoule form, and consisting entirely or predominantly of plastic materials, having a container body () for receiving a filling product (), which can be removed via a releasable container opening () after a closure part () has been removed, which is detachably connected to the neck part () of the container body () along a separation line () in an unopened position, is characterized in that, in the unopened position, a conically extending wall () on the neck part () on the container body () and a conically () or cylindrically extending wall () on the closure part () adjoin the separation line (), and that these walls () delimit at least part of an annular space (), one end of which opens out into the environment and the other end of which opens out into the separation line (). 11012221814102036141038381820363838404020aaa. A container , in particular in ampoule form , and consisting entirely or predominantly of one or more plastic materials , having a container body () for receiving a filling product () , which can be removed via a releasable container opening () after a closure part () has been removed , which is detachably connected to the neck part () of the container body () along a separation line () in an unopened position , characterized in that , in the unopened position , a conically extending wall () on the neck part () on the container body () and a conically () or cylindrically extending wall () on the closure part () adjoin the separation line () , and that these walls ( , , ) delimit at least a part of an annular space ( , ) , one end of which opens out into the environment and the other end of which opens out into the separation line ().236143818424440. The container according to claim 1 , characterized in that the conical wall () on the neck part () and the wall () on the closure part () are formed in the manner of truncated cones ( claim 1 , ) and claim 1 , placed inside each other claim 1 , delimit the annular space (). ...

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Номер записи: 13
04-02-2016 дата публикации

Apparatus and Method for Opening Ampoules

Номер: US20160031692A1
Автор: RIVERSTONE Glen Stanley
Принадлежит:

An ampoule opener () has a cylindrical body portion () with a cavity () at an end thereof adapted to receive at least part of the head portion () of an ampoule (). A retaining mechanism, such as an resiliently expandable O-ring (), is provided at the entrance to the cavity () for retaining the head portion () at least partially within the cavity () after it has been inserted therein. The head portion () may be detached from the remainder of the ampoule () by holding the ampoule () in a first hand with the head portion uppermost, holding the cylindrical body portion () having the head portion () retained therein in the other hand with the thumb uppermost, and causing relative movement between the body portion () and the ampoule (). The ampoule opener () includes a plunger () for ejecting the head portion () from the cavity after it has been detached. 118-. (canceled)20. An apparatus as claimed in wherein the annular groove has an internal diameter which is greater than the external diameter of the O-ring such that a space is provided between the outer circumferential surface of the toroidal O-ring and the internal circumferential surface of the annular groove claim 19 , whereby the O-ring is expandable laterally outwardly within the annular groove.21. An apparatus as claimed in wherein the elongate member has a concave portion at its end adapted to contact the head portion of the ampoule and retain the head portion centrally relative to the entrance of the cavity after it has been detached.22. An apparatus as claimed in wherein the body portion is of generally tubular shape.23. An apparatus as claimed in wherein the body portion has a cavity at each axial end thereof claim 22 , the cavity at one end having a different diameter from the cavity at the other end.24. An apparatus as claimed in wherein the external surface of the body portion has a flat portion extending axially along its length claim 22 , to prevent the body portion from freely rolling about its axis.25. ...

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Номер записи: 14
24-04-2014 дата публикации

"Pre-Filled Active Vial Having Integral Plunger Assembly"

Номер: US20140114274A1
Автор: Hottovy Tracy Ray, Schiller Eric
Принадлежит:

A pre-filled vial assembly adapted for dispensing and delivering a fluid includes: a body member having a distal end, a proximal end, and a sidewall extending therebetween defining an interior; and a transitionable stopper disposed within the interior of the body member. At least a portion of the body member is engageable with a source of air or fluid for advancing the transitionable stopper from an initial position to an activated position in which at least a portion of a fluid contained within the interior of the body member is advanced therefrom. 1. A pre-filled pod assembly comprising:a pre-filled pod having a distal end, a proximal end, and a sidewall extending therebetween defining an interior;a capsule having a fluid contained therein and disposed within the interior of the pre-filled pod, the capsule comprising a first opening adjacent a first end of the capsule and aligned with the proximal end of the pre-filled pod, and a second opening adjacent a second end of the capsule and aligned with the distal end of the pre-filled pod; anda transitionable stopper disposed within the interior of the pre-filled pod between the proximal end of the pre-filled pod and the first end of the capsule,wherein at least a portion of the pre-filled pod is engageable with a source of air or fluid for advancing the transitionable stopper such that air disposed between the capsule and the transitionable stopper is pressurized and enters the capsule via the first opening, thereby expelling at least a portion of the fluid from within the capsule through the second opening.2. The pre-filled pod assembly of claim 1 , wherein at least a portion of the transitionable stopper seals the first opening after the transitionable stopper has advanced completely.3. The pre-filled pod assembly of claim 1 , wherein a volume of the fluid within the capsule is greater than a volume of air disposed between the capsule and the transitionable stopper claim 1 , which limits expulsion of the air from ...

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Номер записи: 15
04-02-2021 дата публикации

MICRO DROP ADAPTER FOR DROPPER BOTTLES

Номер: US20210030589A1
Автор: Enemark Paul
Принадлежит:

A micro drop adapter that is adapted to engage with dropper bottles. The micro drop adapter engages with and surrounds the original tip of the bottle. The micro drop adapter comprises at least one inner tube that is urged against the original tip of the bottle forming a seal and a channel in fluid connection with the bottle. The micro drop adapter comprises an adapter tip that dispenses micro drops, which are drops having a volume of less than approximately 50 microliters. The micro drop adapter further comprises a cap. 1. A micro drop adapter for a container having an original dispensing tip comprising:an assembly having a secondary tip for attaching to a container and configured to reduce a volume of a droplet of fluid ejected from the container;the secondary tip is connected to an adapter configured to thread onto the container;the assembly is removably securable to the container without removal of the original dispensing tip of container;the container is a squeeze type container; andthe volume of the droplet ejected from the container is reduced on a microliter scale as the assembly is configured to reduce the volume of the droplet ejected per squeeze to a micro drop volume.2. The micro drop adapter of claim 1 , the secondary tip comprises a circumferential groove that interconnects with a circumferential ring of the adapter to capture the secondary tip within the adapter.3. The micro drop adapter of claim 2 , the assembly comprising a cap to cap the secondary tip when the cap is connected to the adapter.4. The micro drop adapter of further comprising a cap retainer to retain the cap on the adapter.5. The micro drop adapter of claim 3 , the cap comprising at least one grip enhancer to assist removal of the cap.6. The micro drop adapter of claim 3 , the cap comprising at least one type of grip enhancer to assist removing the cap from the adapter.7. The micro drop adapter of claim 3 , the cap comprising at least two types of grip enhancers to assist removing the ...

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Номер записи: 16
04-02-2021 дата публикации

Container, Particularly for Medical Products, Pharmaceuticals, Cosmetics, Food or the Like

Номер: US20210030622A1
Автор: Fangarezzi Filippo, Folchini, JR. Enrico, Salvarani Enrico
Принадлежит:

The container (), particularly for medical products, pharmaceuticals, cosmetics, food or the like, comprises: 16.-. (canceled)71. Container () , particularly for medical products , pharmaceuticals , cosmetics , food or the like , comprising:{'b': 2', '3', '4', '5, 'at least one hollow body () at least partly compressible defining at least one chamber () for containing at least one fluid product () and provided with at least one neck ();'}{'b': 6', '2', '7', '2', '8', '6', '2', '2', '9', '4, 'at least one closure element () made in a single body piece with said hollow body () and provided with at least one attachment portion () which, in a packaging configuration, is associated with said hollow body () along at least one predefined breaking line () adapted to allow the separation of said closure element () from said hollow body () in a configuration of separation in which on said hollow body () is formed at least one dispensing opening () of said fluid product ();'}{'b': 13', '4', '9', '14', '15', '3', '14', '16', '15', '3, 'at least one dispensing valve () adapted to allow the outflow of said fluid product () through said dispensing opening () and at least one return valve () adapted to allow the one-way flow of air () towards said chamber (), wherein said return valve () comprises filtering means () adapted to filter said air () entering said chamber (); and'}{'b': 14', '13', '13', '14', '17', '9, 'wherein said return valve () is integrated in said dispensing valve () to form a valve assembly (, ) arranged in said dispensing channel () in the proximity of said dispensing opening ().'}81132815314. Container () according to claim 7 , wherein said dispensing valve () comprises at least one internal through duct () adapted to allow the entry of said air () into said chamber () and in which said return valve () is housed.91141628153. Container () according to claim 8 , wherein said return valve () comprises said filtering means () housed in an immoveable manner in said ...

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Номер записи: 17
04-02-2021 дата публикации

ARRANGEMENT AND METHOD FOR PROVIDING A FORMULATION FOR PARENTERAL NUTRITION

Номер: US20210030624A1
Автор: Barkman Tomas, Bohlin Joakim
Принадлежит:

The invention relates to an arrangement and a method for preparing a formulation for parenteral nutrition. In more detail the invention relates to a mixing system for parenteral nutrition, comprising at least two containers, wherein the at least two containers form a modular system. The mixing system comprises a septum, which is pierceable by a spike or a needle and a hanger for attaching the mixing system to an infusion rack. A first container comprises a male connector and a second container comprises a female connector, which fit together. First and second container can be coupled together, thereby forming a channel, which enables the passage of liquid and the mixing of the ingredients of the containers. 120-. (canceled)21. A mixing system for parenteral nutrition , said mixing system comprising at least two containers that form a modular system , said at least two containers comprising a first container filled with a first liquid for parenteral nutrition and a second container filled with a second liquid for parenteral nutrition , wherein said mixing system further comprises a septum and a hanger , wherein said septum is pierceable by a spike or a needle , wherein said hanger is configured for attaching said mixing system to an infusion rack , wherein said first container comprises a male connector and said second container comprises a female connector that fits said male connector , wherein said first and second containers are configured to be coupled together by connecting said male and female connectors so as to form a channel that enables passage of liquid , said channel permitting mixing of said first and second liquids.22. The mixing system of claim 21 , wherein said at least two containers comprises a third container claim 21 , wherein said first container contains amino acids claim 21 , said second container contains glucose claim 21 , and said third container contains fat.23. The mixing system of claim 21 , wherein said first container further comprises ...

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Номер записи: 18
04-02-2021 дата публикации

CONTAINERS HAVING CLOSED ENDS, CONTAINER ASSEMBLIES AND MEDICAL DEVICES HAVING SUCH CONTAINERS

Номер: US20210030964A1
Автор: Bauert Dominique, Busimi Anil-Kumar, Kloke Arne
Принадлежит: SCHOTT Schweiz AG

Container assemblies for accommodating pharmaceutical compositions are provided. The container assembly includes a container and a plunger. The container has a hollow cylindrical body with an open end and a closed end, which is closed by a bottom portion. The hollow cylindrical body has a length (L), an outer diameter (DO), and an inner diameter with a length to outer diameter ratio between 3:1 and 15:1. The hollow cylindrical body and the bottom portion are formed integrally and of the same material, which is a glass or polymer material. The container has an inner surface with an average Zn-leachability of 0.00085 μg/cmor less. The plunger is inside the hollow cylindrical body at the open end, is pierceable by a cannula, and is slidable relative to the hollow cylindrical body from the open end towards the closed end. 1. A container for accommodating pharmaceutical compositions , comprising:a hollow cylindrical body with an open end and a closed end opposite to the open end, the open end and the hollow cylindrical body being configured to receive a plunger that is slidable relative to the hollow cylindrical body from the open end to the closed end, the closed end being closed by a bottom portion, the hollow cylindrical body and the bottom portion being formed integrally and of a common material, which is a glass or polymer material, the hollow cylindrical body having an inner surface, a length (L) between 35 mm and 120 mm, an outer diameter (DO) between 8.65 mm and 30 mm, and an inner diameter;a length to outer diameter ratio between 3:1 and 15:1; and{'sup': '2', 'an average Zn-leachability of the inner surface of 0.00085μg/cmor less.'}2. The container assembly of claim 1 , wherein the common material has a compaction of 200μm/100 mm or less.3. The container assembly of claim 1 , wherein the common material is selected from a group consisting of a borosilicate glass claim 1 , an alumino-silicate glass claim 1 , a cycloolefin copolymer claim 1 , and a cycloolefin ...

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Номер записи: 19
12-02-2015 дата публикации

AUTOINJECTOR APPARATUS

Номер: US20150045729A1
Автор: Denzer Michael, Ewing Kenneth R., Ganzitti Gabriele, Johnston Neal D., Krishna Suhas, Swift Robert W.
Принадлежит: Amgen, Inc.

An autoinjector apparatus is disclosed which comprises a single-use cassette and an autoinjector. The cassette comprises a housing and a sleeve movably disposed in the housing. A syringe may be disposed in the sleeve and secured therein with a lock cap. The lock cap is affixed to a distal end of the sleeve and contacts the distal end of the syringe. A shield remover extends through an opening in a proximal end of the housing for removing a needle shield which covers a needle of the syringe. A cassette identification arrangement is provided on a surface of the housing to enable the autoinjector to identify the cassette. The autoinjector is provided with a detector for reading the cassette identification arrangement. 1. A single-use cassette for use with an autoinjector , the cassette comprising:a housing;a sleeve disposed in the housing and movable between first and second positions, wherein the sleeve is capable of having a syringe disposed therein; anda lock cap for securing the syringe in the sleeve, the lock cap affixed to a distal end of the sleeve and capable of contact with the distal end of the syringe.2. The cassette of claim 1 , wherein the lock cap comprises an elastomeric bumper that is capable of contact with the distal end of the syringe.3. The cassette of claim 1 , wherein the inner sleeve comprises at least one receptacle at the distal end thereof and the lock cap comprises at least one arm member inserted into the receptacle.4. The cassette of claim 3 , wherein the at least one arm member of the lock cap comprises a barb arrangement for gripping an inner surface of the receptacle of the inner sleeve.5. The cassette of claim 1 , further comprising a syringe having a barrel and an injection needle disposed in the sleeve.6. The cassette of claim 1 , wherein the cassette further comprises a shield remover extending through an opening in a proximal end of the housing for removing a needle shield from the syringe.7. The cassette of claim 6 , wherein the ...

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Номер записи: 20
14-02-2019 дата публикации

Coded collapsible drug reservoir

Номер: US20190046396A1
Автор: Richard James Vincent Avery
Принадлежит: Sanofi Aventis Deutschland GmbH

A coded collapsible drug reservoir and a drug delivery system including the coded collapsible drug reservoir. The drug reservoir includes a collapsible housing and a port in communication with the collapsible housing. The drug reservoir further includes a coding feature disposed on the drug reservoir, and the coding feature identifies the drug reservoir.

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Номер записи: 21
10-03-2022 дата публикации

FILING SYSTEM AND METHODS FOR ASEPTIC CARTRIDGE AND DISPENSER ARRANGEMENT

Номер: US20220071844A1
Автор: Genosar Amir
Принадлежит:

A package for use with a beneficial agent delivery device. The package includes at least one filling chamber having a sealed penetrable access region, at least one compartment configured to hold a content, wherein the content includes at least one of a beneficial agent or a constituent of a beneficial agent, and at least one channel connecting the at least one filling chamber in fluid communication with the at least one compartment. At least a portion of the package is resealable to contain the content. 120.-. (canceled)21. A cartridge for use with an injector , comprising:a first wall that comprises at least a first cavity;a second wall in sealing engagement with the first wall to define at least a first sealed compartment at least partially defined by the first cavity, wherein the first sealed compartment is adapted to contain a first deliverable substance; anda fitment to selectively provide fluid communication between the first sealed compartment and a reservoir of the injector via a passageway of the fitment to transfer the first deliverable substance from the first sealed compartment to the reservoir of the injector, wherein the fitment defines at least a portion of an aseptic zone through which the first deliverable substance is transferred between the cartridge and the reservoir.22. The cartridge of claim 21 , wherein the fitment is adapted to form a fluid-tight seal with a nozzle of the injector.23. The cartridge of claim 22 , wherein the injector is a jet injector and the nozzle of the injector with which the fitment is adapted to engage includes a jet nozzle claim 22 , and wherein the fitment engages the nozzle to define the aseptic zone through with the first deliverable substance is transferred between the cartridge and the reservoir.24. The cartridge of claim 21 , wherein the fitment is attached to an outer side of one of the first wall and the second wall claim 21 , the one of the first wall and the second wall including a through hole providing the ...

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Номер записи: 22
28-02-2019 дата публикации

VIAL CLOSURE FOR REHYDRATING MEDICATION

Номер: US20190060169A1
Автор: Price Cory
Принадлежит:

A vial cap is configured to releasably contain a portion of a material, for example a powdered medication, for dispensing into a container. Via operation of a depressable plunger, the material is released into the container for rehydrating and mixing with a liquid, and thereafter may be extracted, such as via a needle. In this manner, a rehydrated medication may be provided in a predetermined amount and at a desired time. 1. A cap for a container holding a liquid , the cap comprising:a cap body comprising a durable material, the cap body configured with a space for containing an anhydrous material;a depressable plunger coupled to the cap body, the depressable plunger having an extended portion to release the anhydrous material into the liquid when the depressable plunger is depressed;a flexible o-ring operable as a seal for the depressable plunger; anda septum disposed at least partially within the depressable plunger, the septum operable to permit a needle to pass therethrough to access the liquid.2. The cap of claim 1 , wherein the o-ring and the septum are monolithic.3. The cap of claim 1 , wherein the depressable plunger is protected from accidental activation by being at least partially contained within the cap body.4. The cap of claim 1 , further comprising a releasable agitator disposed in the space for containing the anhydrous material.5. The cap of claim 1 , wherein the anhydrous material is a medication that must be administered intravenously.6. The cap of claim 1 , wherein the depressable plunger comprises a heel that forces a portion of a membrane into an opened position claim 1 , and wherein the membrane at least partially surrounds the anhydrous material.7. The cap of claim 1 , wherein the depressable plunger locks into a depressed position after being depressed.8. A method for rehydrating a powdered medication in preparation for intravenous injection claim 1 , the method comprising:coupling a vial cap containing the powdered medication to a vial ...

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Номер записи: 23
28-02-2019 дата публикации

UNIT DOSE DISPENSING MECHANISMS

Номер: US20190060175A1
Автор: Fisher Herbert Lawson, Mehta Vikram, Moreno Gerardo, Trejo Guillermo, Wilson Edith
Принадлежит:

Mechanisms for dispensing items such as medications and medical supplies. Different mechanisms may be tailored to dispensing different kinds of items, for example medications in single dose packages, vials, syringes, or other similarly-shaped items. The dispensers may be placed in a dispensing unit that includes a lockable restock drawer and a dispense drawer into which items are dispensed by the dispensing mechanisms. The various kinds of dispensing mechanisms may be installed in the restock drawer in any workable proportion and arrangement. The dispensing mechanisms include multiple sensing technologies for tracking and inventory of items and for accurate sensing of items as they are dispensed. 112-. (canceled)13. A dispensing mechanism , comprising:a set of vertical channels of a shape and size to receive a number of vials and hold the vials in vertical stacks;a connector for receiving electrical signals from a cabinet in which the dispensing mechanism is removably installed;an actuator that moves in response to the electrical signals;a plurality of rotatable receivers driven by the actuator, each of the rotatable receivers being positioned under a respective one of the vertical channels and defining an open-sided cavity of a shape and size to receive a vial; anda housing defining opening at the bottom of the dispensing mechanism;wherein when the rotatable receivers are rotated, their respective cavities sequentially align with the vertical channels, such that upon alignment, one of the vials drops into the respective cavity through the open side of the cavity, and when one of the cavities holding a vial approaches a downward vertical orientation, a single vial drops from the open side of the downwardly-oriented cavity and through the opening.14. The dispensing mechanism of claim 13 , wherein the actuator comprises a motor claim 13 , a solenoid claim 13 , or a memory metal.15. The dispensing mechanism of claim 13 , wherein the actuator is a rotary actuator and ...

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Номер записи: 24
28-02-2019 дата публикации

UNIT DOSE DISPENSING MECHANISMS

Номер: US20190060176A1
Автор: Berken Lloyd, Fisher Herbert Lawson, Mehta Vikram, Moreno Gerardo, Trejo Guillermo, Wilson Edith
Принадлежит:

Mechanisms for dispensing items such as medications and medical supplies. Different mechanisms may be tailored to dispensing different kinds of items, for example medications in single dose packages, vials, syringes, or other similarly-shaped items. The dispensers may be placed in a dispensing unit that includes a lockable restock drawer and a dispense drawer into which items are dispensed by the dispensing mechanisms. The various kinds of dispensing mechanisms may be installed in the restock drawer in any workable proportion and arrangement. The dispensing mechanisms include multiple sensing technologies for tracking and inventory of items and for accurate sensing of items as they are dispensed. 1. A dispensing mechanism , comprising:a connector for receiving electrical signals from a cabinet in which the dispensing mechanism is installed;an actuator that operates in response to the electrical signals;a non-circular sprocket driven by the actuator, wherein the teeth of the non-circular sprocket are not all the same distance from an axis of rotation of the non-circular sprocket;a belt driven by the sprocket, the belt comprising a plurality of links, and the belt configured to circulate within a chamber when driven by the actuator;a plurality of paddles integrally formed with the links of the belt for receiving between pairs of the paddles items to be dispensed, the paddles extending from the belt; anda housing defining the chamber and defining an opening at the bottom of the chamber, such that a single item drops from between its respective paddles and through the opening when the segmented belt is incrementally advanced and the paddle supporting the item approaches a vertical orientation due to the advancement of the belt.2. The dispensing mechanism of claim 1 , wherein each of the paddles is L-shaped in cross section claim 1 , and wherein the paddles are pinned together in alternating orientation claim 1 , with each paddle joined to one adjacent paddle at the ...

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Номер записи: 25
22-05-2014 дата публикации

IMPLANTABLE DRUG DELIVERY DEVICES

Номер: US20140142556A1
Автор: Kuo Youti, Violante Michael R.
Принадлежит:

The invention relates generally to implantable drug delivery devices. Devices having a single drug chamber configuration, a divided drug chamber configuration and a compact dual-drug configuration are described. The devices have features to prevent clogging of the dispensing catheter and the creation of a local vacuum caused by the dispensing of the drug fluid. Also provided are features of a failsafe refilling process, automatic refill notification, and performance verification process. The divided drug chamber configuration enables frequent or continuous minute doses. A dual-drug chamber configuration uses self-locking refill containers to prevent mismatching between refill containers and drug chambers. 113-. (canceled)14. A refill container for refilling an implantable drug delivery device comprising:a. a tubular housing with inner wall surface having first opening and second opening, said tubular housing containing a drug fluid,b. a needle being attached to the second opening, said needle being in flow communication with the tubular housing,c. a disc situated inside said tubular housing in slidable sealing fit with an inner wall surface, said disc not accessible from outside the housing and being only movable following the flow direction toward the needle when the drug fluid is being removed from the housing through the needle, said disc being exposed to ambient pressure through the first opening.15. A refill container for refilling an implantable drug delivery device comprising:a. a collapsible pouch containing a drug fluid having a flexible film wall fastened to a top plate having an exit opening, said film wall being collapsible when the drug fluid is drawn through the exit opening,b. a needle being attached to the exit opening of the top plate and being in flow communication with the collapsible pouch.1619-. (canceled)20. An implantable drug delivery device system comprising:a. a refill container comprising housing walls, a reservoir containing a drug fluid ...

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Номер записи: 26
23-03-2017 дата публикации

METHOD OF SEALING A CONTAINER COMPRISING AT LEAST ONE PLUG, PARTICULARLY A CARPULE, INSERTION MEANS AND ASSOCIATED SEALING LINE

Номер: US20170081056A1
Автор: PAUCHDET Bernard, Zambaux Jean-Pascal
Принадлежит:

Disclosed is a method of sealing a container with a liquid, the container including a body with an opening at at least one end and including at least one sealing plug, designed to seal the opening after filling, the filling defining a free surface S for filling, the filling having allowed a head space to remain in the container. The method includes: introduction of at least one rod parallel to an inside wall of the body of the container; mechanical insertion of the plug in the body, along the at least one insertion rod, generating at least one channel C, the air of the head space being evacuated between the plug and the rod; and withdrawal of the at least one rod while leaving the plug in place at the level of insertion of the preceding step. Also disclosed are the associated device and the industrial production line. 110141. Method of sealing a container with a liquid , said container comprising a body () with an opening at at least one end and comprising at least one sealing plug (-) , designed to seal said opening after filling , said filling defining a free surface S for filling , the filling having allowed a head space to remain in said container , the method comprising:{'b': 18', '1', '10, 'a) introducing at least one rod (-) parallel to an inside wall of the body () of said container,'}{'b': 14', '1', '10', '18', '1, 'b) mechanically inserting said plug (-) into the body (), along the at least one insertion rod (-), generating at least one channel C, the air of the head space being evacuated between said plug and said rod,'}{'b': 18', '1, 'c) withdrawing said at least one rod (-) while leaving said plug in place at the level of insertion of the preceding step.'}2181141. Method of sealing a container with a body comprising an opening at at least one end claim 1 , according to claim 1 , wherein the steps a) for introduction of the rod (-) and b) for insertion of the plug (-) are simultaneous.31811610. Method of sealing a container with a body comprising an ...

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Номер записи: 27
26-03-2015 дата публикации

MEDICAL RUBBER PARTS

Номер: US20150086802A1
Автор: MAEDA Katsushi, MASUYAMA Yoshikazu
Принадлежит:

The present invention provides, medical rubber parts that do not physically and chemically affect the quality of preparations. The present invention relates to a medical rubber part obtained by press-molding an unvulcanized rubber mainly containing a rubber for forming a liquid-contacting portion and an unvulcanized rubber mainly containing a butyl-based rubber for forming a non-liquid-contacting portion, wherein a color difference dE between the liquid-contacting portion and the non-liquid-contacting portion is 6.0 or more in NBS units. 1. A medical rubber part , obtained by press-molding an unvulcanized rubber mainly containing a rubber for forming a liquid-contacting portion and an unvulcanized rubber mainly containing a butyl-based rubber for forming a non-liquid-contacting portion ,wherein a color difference dE between the liquid-contacting portion and the non-liquid-contacting portion is 6.0 or more in NBS units.2. The medical rubber part according to claim 1 ,wherein the color difference dE is 12.0 or more in NBS units.3. The medical rubber part according claim 1 ,wherein in the unvulcanized rubber for forming a liquid-contacting portion or a non-liquid-contacting portion, an amount of color pigments other than titanium oxide is 0 to 3.0 parts by mass and an amount titanium oxide is 0 to 5.0 parts by mass, each per 100 parts by mass of a rubber component of the unvulcanized rubber.4. The medical rubber part according to claim 1 ,wherein a density difference between the liquid-contacting portion and the non-liquid-contacting portion is 0.02 or less.5. A vial rubber stopper claim 1 , comprising the medical rubber part according to .6. A pre-filled syringe gasket claim 1 , comprising t medical rubber part according to .7. A nozzle cap claim 1 , comprising the medical rubber part according to . The present invention relates to medical rubber parts such as a vial rubber stopper, a pre-filled syringe gasket, and a nozzle cap.Rubber parts for medical use are known ...

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Номер записи: 28
26-03-2015 дата публикации

RECONSTITUTION DEVICE

Номер: US20150088089A1
Автор: BARTLETT, Dennis Joseph D., Greco Peter M., II Rush L., KELLEY Brian C., McKenzie Christopher P., Predmore Kevin D.
Принадлежит:

An apparatus () includes a body (), a plunger (), and an occlusion (). The body is able to hold one or more medical substances therein. The body defines a longitudinal axis extending therethrough. The plunger is positioned within a portion of the body and is able to axially advance along the longitudinal axis. The plunger also defines an opening extending therethrough. The occlusion is able to extend through at least a portion of the opening of the plunger so that the plunger and the occlusion fluidly divide the body. The plunger is able to exert a first outward force against the body. The plunger is able to exert a second outward force against the body when the occlusion has been removed where the second outward force is less than the first outward force. 1. An apparatus comprising:(a) a body configured to hold one or more medical substances therein, wherein the body defines a longitudinal axis extending therethrough;(b) a plunger positioned within a portion of the body, wherein the plunger is configured to axially advance along the longitudinal axis of the body, wherein the plunger defines an opening extending therethrough; and(d) an occlusion configured to extend through at least a portion of the opening of the plunger such that the plunger and the occlusion are operable to fluidly divide the body, wherein the plunger is configured to exert a first outward force against the body with the occlusion inserted in at least a portion of the opening, wherein the plunger is configured to exert a second outward force against the body when at least a portion of the occlusion has been removed from the opening.2. The apparatus of claim 1 , wherein the occlusion comprises a plug.3. The apparatus of claim 2 , wherein the plug is configured to dislodge from the plunger in a single direction.4. The apparatus of claim 1 , further comprising a rear plunger configured to axially advance to urge the occlusion from the plunger.5. The apparatus of claim 4 , wherein the rear plunger is ...

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Номер записи: 29
25-03-2021 дата публикации

GLASS SYRINGE BARRELS WITH INCREASED CONE BREAKING FORCES

Номер: US20210085877A1
Автор: Andreoli Ivo, Langsdorf Andreas, Oberhänsli Roman, Strassmann Martha, THOMAS Peter
Принадлежит: SCHOTT AG

A glass syringe barrel is provided that has an at least partially conically shaped upper portion and a longitudinal axis. The glass syringe barrel has a top end through which a liquid can be ejected and a bottom end into which a plunger stopper can be pushed. The glass syringe barrel includes, in a direction from the top end to the bottom end, a cone, a shoulder region, and a body region. The shoulder region has and outer contour that has a concave and substantially circular arc-shaped area cwith an outer radius r. The outer contour of the glass syringe barrel in the shoulder region is defined by a certain minimum value the radius of curvature. 1. A glass syringe barrel , comprising:a top end through which a liquid can be ejected;a bottom end into which a plunger stopper can be pushed;{'sub': 'barrel', 'a longitudinal axis Lthrough the top and bottom ends; and'}{'sub': 1', '1, 'a cone region having a first end that corresponds to the top end and a second end, the cone region has a length land has an outer diameter dat the second end;'}{'sub': 1', '1', '2', '2, 'a shoulder region having a first end that is adjacent to the second end of the cone region and a second end, wherein the shoulder region has an outer contour that comprises a concave and substantially circular arc-shaped area cwith an outer radius rbeginning below the second end of the cone region and a convex and substantially circular arc-shaped area cwith an outer radius rbeginning above the second end of the shoulder region; and'}{'sub': 2', '2, 'a body region having a first end that is adjacent to the second end of the shoulder region and a second end that corresponds to the bottom end, wherein the body region has an outer diameter dand a glass thickness n,'}{'sub': barrel', '1', '2', '2', '1', '2', '2', '1', '2, 'sup': 2', '3/2', '2', '−1, 'b': '100', 'wherein, if an outer surface of the body region is placed on a plane horizontal substrate, within any given cross-section of the glass syringe barrel ...

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Номер записи: 30
25-03-2021 дата публикации

GLASS SYRINGE BARRELS WITH INCREASED CONE BREAKING FORCES

Номер: US20210085878A1
Автор: Andreoli Ivo, Langsdorf Andreas, Oberhänsli Roman, Strassmann Martha, THOMAS Peter
Принадлежит: SCHOTT AG

A glass syringe barrel is provided that has an at least partially conically shaped upper portion and a longitudinal axis. The glass syringe barrel has a top end through which a liquid can be ejected and a bottom end into which a plunger stopper can be pushed. The glass syringe barrel includes, in a direction from the top end to the bottom end, a cone, a shoulder region, and a body region. The shoulder region has and outer contour that has a concave and substantially circular arc-shaped area ci with an outer radius r. The outer contour of the glass syringe barrel in the shoulder region is defined by a certain value for r. 1. A glass syringe barrel , comprising:a top end through which a liquid can be ejected;a bottom end into which a plunger stopper can be pushed;{'sub': 'barrel', 'a longitudinal axis Lthrough the top and bottom ends; and'}{'sub': 1', '1, 'a cone region having a first end that corresponds to the top end and a second end, the cone region has a length land has an outer diameter dat the second end;'}{'sub': 1', '1', '2', '2, 'a shoulder region having a first end that is adjacent to the second end of the cone region and a second end, wherein the shoulder region has an outer contour that comprises a concave and substantially circular arc-shaped area cwith an outer radius rbeginning below the second end of the cone region and a convex and substantially circular arc-shaped area cwith an outer radius rbeginning above the second end of the shoulder region; and'}{'sub': 2', '2', '1, 'a body region having a first end that is adjacent to the second end of the shoulder region and a second end that corresponds to the bottom end, wherein the body region has an outer diameter dand a glass thickness n, wherein ris in a range from 0.5 to 3 mm.'}2. The glass syringe barrel of claim 1 , wherein the outer radius ris in a range from 0.6 to 2.5 mm.3. The glass syringe barrel of claim 2 , wherein the outer radius ris in a range from 0.7 to 2 mm.4100. The glass syringe barrel ...

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Номер записи: 31
25-03-2021 дата публикации

Liquid applicator

Номер: US20210085942A1
Автор: Alan R. Dombrowski, Robert A. Asmus
Принадлежит: 3M Innovative Properties Co

The disclosed applicator includes an activation region having one or more pinch point levers in the cover of the applicator. Within the cover of the applicator is a deformable body and disposed within the deformable body is a frangible ampoule containing a solution. A user activates the pinch point levers to deform the deformable body and crush the frangible ampoule, releasing the solution. The hinging connection of the pinch point lever reduces the break strength needed in order to crush the ampoule, while the deformable body provides a safe barrier to protect the user against glass shards.

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Номер записи: 32
19-03-2020 дата публикации

DERMAL ADHESIVE PATCH

Номер: US20200086099A1
Автор: LEE Ji Hyun, SEO In Yong
Принадлежит: AMOLIFESCIENCE CO., LTD.

A dermal adhesive patch is provided. The dermal adhesive patch according to an exemplary embodiment of the present invention is adhered to skin through an ampoule containing a mixing ingredient, a drying ingredient, a viscosity control ingredient, and a moisturizing ingredient. The dermal adhesive patch comprises: a support body; and a membrane layer formed as a nanofiber web having pores to block moisture and to allow air to pass through the membrane layer, and detachably laminated on one surface of the support body. 1. A dermal adhesive patch that is attached to skin through an ampoule containing a mixing ingredient , a drying ingredient , a viscosity control ingredient , and a moisturizing ingredient , the patch comprising:a support body; anda membrane layer formed as a nanofiber web having pores to block moisture and to allow air to pass through the membrane layer, and detachably laminated on one surface of the support body.2. The patch of claim 1 , wherein the membrane layer is a nanofiber web which is formed to have pores by electrospinning a spinning solution claim 1 , in which a synthetic polymer and a solvent are mixed.3. The patch of claim 2 , wherein an average pore diameter of the pores is less than or equal to 10 μm.4. The patch of claim 2 , wherein the membrane layer is attached to a user's skin and serves as a protective layer that protects the ampoule.5. The patch of claim 1 , wherein the ampoule is a mixed solution in which water claim 1 , alcohol claim 1 , a polymer claim 1 , and oil are mixed at a predetermined ratio.6. The patch of claim 1 , wherein the ampoule further contains a functional component.7. The patch of claim 1 , wherein the membrane layer includes a shape-retaining layer which is laminated on the one surface of the support body and is formed as a nanofiber web in which nanofibers containing a synthetic polymer are accumulated claim 1 , anda medicinal solution layer which is laminated on one surface of the shape-retaining layer and ...

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Номер записи: 33
14-04-2016 дата публикации

DEVICE TO PREPARE AND ADMINISTER TWO-COMPONENT MIXTURE

Номер: US20160100875A1
Автор: FACCIOLI Giovanni, SOFFIATTI Renzo
Принадлежит:

A device to prepare and administer a two-component mixture, including a first chamber in which a container is housed that is hermetically closed for a liquid component, a second chamber containing a powdered component, an opening of the container of the liquid component, a mixing member placed in the second chamber for preparing the mixture and a piston able to move in the second chamber to dispense the mixture. The mixing member includes a stem, passing through an opening for dispensing the mixture in the second chamber, having an outer end equipped with a handle and an inner end provided with a mixing blade connected to the inner end with a releasable connection. 1. A method for preparing and administering a two-component mixture , actuated with a device , wherein the method comprises the following steps:breaking a container of a liquid component;transferring the liquid component from a first chamber to a second chamber;mixing the liquid component and a powdered component through a mixing member, making a mixture;removing a stem of said mixing member; andacting upon a piston to dispense said mixture.2. The method of claim 1 , wherein the container is housed in the first chamber that is hermetically closed for the liquid component.3. The method of claim 1 , wherein the second chamber contains the powdered component and communicates with said first chamber.4. The method of claim 1 , further comprising means for opening said container of the liquid component and wherein the mixing member is associated with said second chamber for preparing the mixture.5. The method of claim 1 , wherein the piston is able to move in said second chamber to dispense the mixture.6. The method of claim 1 , wherein said mixing member comprises means for actuating the mixing member itself claim 1 , said actuation means being able to be actuated from outside of the device claim 1 , said actuation means and said mixing member being associated through releasable connection means.7. The method ...

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Номер записи: 34
02-04-2020 дата публикации

PRIMARY PACKAGING CONTAINERS FOR PHARMACEUTICAL SUBSTANCES AND METHODS OF MAKING

Номер: US20200100985A1
Автор: Auerbach Judith
Принадлежит: SCHOTT Schweiz AG

A primary packaging container for pharmaceuticals is provided. The container includes a hollow body, an opening, and a closure. The hollow body has an opening and is made of a cycloolefin polymer or a cycloolefin copolymer. The closure has a puncture region. The closure closes the opening with the puncturing region at the opening. The puncturing region is configured to allow introduction of a cannula into the hollow body and resealing the hollow body upon withdraw of the cannula. The closure has an elastomer that is connected to the hollow body so as to be not separable in a non-destructive manner. 1. A primary packaging container for receiving a pharmaceutical product , comprising:a hollow body having an opening, the hollow body comprises a cycloolefin polymer or a cycloolefin copolymer; anda closure having a puncture region, the closure closing the opening with the puncturing region at the opening, the puncturing region being configured to allow introduction of a cannula into the hollow body and resealing the hollow body upon withdraw of the cannula,wherein the closure comprises an elastomer that is connected to the hollow body so as to be not separable in a non-destructive manner.2. The primary packaging container of claim 1 , wherein the elastomer is a normal elastomer and/or a thermoplastic elastomer.3. The primary packaging container of claim 1 , wherein the hollow body is a vial or a carpule.4. The primary packaging container of claim 1 , wherein the elastomer is connected in a materially bonded and/or micro-positive manner with the hollow body.5. The primary packaging container of claim 1 , wherein the elastomer and hollow body are connected so as to remain connected after the introduction and removal of the cannula through the puncturing region.6. The primary packaging container of claim 5 , wherein the elastomer closes the opening in a manner selected from a group consisting of sealed manner claim 5 , a fluid-tight manner claim 5 , and a gas-tight manner.7 ...

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Номер записи: 35
26-04-2018 дата публикации

DUAL CHAMBER DISPENSING DEVICE

Номер: US20180110680A1
Автор: Butts Emily, Casola Marisa, Copland Ian B., Patel Nihir, Reavis Ashley
Принадлежит:

Described are single-use dispensing devices with a dry chamber containing lyophilized material, a wet chamber containing reconstituting solution, a breaking chamber positioned between and attached to the dry chamber and a first end of the wet chamber. The breaking chamber includes a leak-proof frangible seal that prevent mixing of the lyophilized material and the reconstituting solution until the frangible seal is broken. 1. A single-use dispensing device comprising:a dry chamber comprising lyophilized material;a wet chamber comprising reconstituting solution;a breaking chamber positioned between and attached to the dry chamber and a first end of the wet chamber, wherein the breaking chamber comprises a leak-proof frangible seal that prevent mixing of the lyophilized material and the reconstituting solution until the frangible seal is broken.2. The single-use dispensing device of claim 1 , wherein the frangible seal comprises at least one perforation.3. The single-use dispensing device of claim 2 , wherein the breaking chamber comprises a polygonal-shaped internal aperture having opposing corners.4. The single-use dispensing device of claim 3 , wherein the breaking chamber is configured to deform when a compression force is applied to an outer band in a location that is proximate the opposing corners.5. The single-use dispensing device of claim 4 , wherein the aperture compresses in a direction between the opposing corners and elongates in a substantially perpendicular direction.6. The single-use dispensing device of claim 5 , wherein the elongation causes the frangible seal to break or tear.7. The single-use dispensing device of claim 3 , wherein the opposing corners comprise slits at an apex of each corner.8. The single-use dispensing device of claim 1 , further comprising a dispensing tip attached to the wet chamber and positioned at a second end of the wet chamber claim 1 , wherein the dispensing tip comprises a detachable enclosure.9. The single-use dispensing ...

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Номер записи: 36
13-05-2021 дата публикации

DISPENSING DEVICE

Номер: US20210139216A1
Автор: Sutherland Spencer D.
Принадлежит:

Dispensing devices are described which can contain at least one substance(s) that can be squished, emptied, extruded, and/or poured out. The dispensing devices can comprise a deformable housing including a top portion and a bottom portion forming an internal volume, a circumferential edge portion, and a dispensing port. 1. A dispensing device comprising:a deformable housing including a top portion and a bottom portion forming an internal volume;a circumferential edge portion; anda dispensing port wherein the dispensing port is elevated on the top portion of the deformable housing and the dispensing port is substantially flat along the circumferential edge portion.2. A dispensing device according to claim 1 , wherein the internal volume is a void.3. A dispensing device according to claim 1 , wherein the internal volume is an encasement.4. A dispensing device according to claim 3 , wherein the encasement contains at least one substance.5. A dispensing device according to claim 4 , wherein the at least one substance is a condiment claim 4 , a personal care product claim 4 , a medicament claim 4 , a health product claim 4 , a beauty product claim 4 , a sports nutrition product claim 4 , an industrial product claim 4 , or an alcoholic beverage.6. A dispensing device according to claim 1 , wherein the circumferential edge portion is a ring claim 1 , securing mechanism claim 1 , border claim 1 , or rim.7. A dispensing device according to claim 6 , wherein the circumferential edge portion separates the dispensing device into the top portion and bottom portion of the deformable housing.8. A dispensing device according to claim 1 , wherein the top portion and bottom portion of the deformable housing include an indent.9. A dispensing device according to claim 8 , wherein the indent on the top portion of the deformable housing is centered.10. A dispensing device according to claim 8 , wherein the indent on the bottom portion of the deformable housing is centered.11. A ...

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Номер записи: 37
03-05-2018 дата публикации

Flexible Container for an Injection Device

Номер: US20180117244A1
Автор: Blancke Stefan, Jugl Michael, Teucher Axel
Принадлежит:

The present disclosure relates to a flexible container for an injection device including a flexible bag having an interior volume to be filled with a liquid medicament, an outlet located at a first end of the bag, and a contraction member connected to the bag to displace a second end of the bag located opposite to the first end towards the first end. 115-. (canceled)16. A flexible container for an injection device , comprising:a flexible bag defining an interior volume configured to be filled with a liquid medicament,an outlet located at a first end of the flexible bag,a contraction member connected to the flexible bag and configured to displace a second end of the flexible bag, located opposite to the first end, towards the first end, wherein at least one of the first end and the second end is flexible.17. The flexible container according to claim 16 , wherein the contraction member is connected to a sidewall of the flexible bag claim 16 , the sidewall being located between the first end and the second end of the flexible bag.18. The flexible container according to claim 16 , wherein the contraction member comprises a helical shaped tension spring having at least two windings extending around the flexible bag.19. The flexible container according to claim 16 , wherein at least one end of the contraction member is located at a predetermined distance from the first end or the second end of the flexible bag.20. The flexible container according to claim 16 , wherein the contraction member comprises at least one of a metallic material and a plastic material.21. The flexible container according to claim 16 , wherein the contraction member is connected to the flexible bag with at least two fixations that are separated from each other in an axial direction.22. The flexible container according to claim 16 , wherein the contraction member is connected to an outside facing portion of the flexible bag.23. The flexible container according to claim 16 , wherein the outlet ...

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Номер записи: 38
04-05-2017 дата публикации

MEDICATION INJECTOR WITH CAPACITIVE FILL LEVEL MEASUREMENT CAPACITY, AND CONTACT SENSOR

Номер: US20170119970A1
Автор: Bammer Manfred, Putz Otmar, Schmid Gernot
Принадлежит:

A medication injector for dispensing liquid medications to people includes a container which is filled with the liquid and which has an opening at one end for dispensing the liquid and at least one pair of capacitive measuring electrodes disposed opposite each other in the outer region of the container, in particular on the wall, for determining the permittivity of the respective medium in the intermediate region between the measuring electrodes. The measuring electrodes are used by the injector to determine the fill level of the container. A shielding surrounds the measuring electrodes in the manner of a sheath, is disposed around the container, and reduces possible external interfering influences on the capacitive measurement, such as those resulting from contact, for example. Additionally, a contact sensor is provided which can indicate the measurement as invalid. 135-. (canceled)36. An administering apparatus provided for administering liquids or liquid medicaments to persons and having a reusable filling level measuring system , the administering apparatus comprising:a container to be filled with the liquid, said container having an end with an opening for administering the liquid and said container having an outer region;at least one pair of capacitive measuring electrodes disposed opposite one another in said outer region of said container for determining a filling level of the liquid in said container;electrical shielding surrounding said at least one pair of capacitive measuring electrodes and said container as a sheath, said electrical shielding being formed of conductor tracks applied to a film, and said shielding being disposed at a radial distance from said at least one pair of capacitive measuring electrodes;a communication controller applied to said film;at least one capacitance measuring device applied to said film for establishing a capacitance between said at least one pair of capacitive measuring electrodes;a computer unit applied to said film;an ...

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Номер записи: 39
24-07-2014 дата публикации

LIQUID CONTAINER WITH PREDETERMINED BREAKING POINT

Номер: US20140202980A1
Автор: Sattig Christoph
Принадлежит: Stryker Ireland Ltd.

Liquid container with a predetermined break point (), which is covered by an elastomer septum (). The container forms a hollow body () made of a single material that is compatible with critical liquids such as medicines. The elastomer septum () and the predetermined break point () can be pierced by a hollow needle () in order to withdraw liquid from the container. 1. A container for containing a liquid , comprising:a hollow body with a cover, with a bottom and with an inner wall made from a single material that is compatible with the liquid,a predetermined breaking point that is provided at the hollow body and can be pierced with the point of a hollow needle and that is formed from a thickness-reduced spot in the cover or in the bottom, andan elastomer septum that covers the predetermined breaking point, is fixedly connected to the hollow body at the cover or bottom thereof and has sufficient thickness so as to guide and to stabilize the hollow needle when piercing the predetermined breaking point and also to seal it at the circumference.2. The container for containing a liquid according to claim 1 , wherein the elastomer septum comprises materials from the group silicone claim 1 , isobutyl rubber and/or neoprene.3. The container for containing a liquid according to claim 1 , wherein the thickness of the septum ranges of from 0.3 to 15 mm claim 1 , preferably of from 0.5 to 10 mm and particularly preferred of from 0.8 to 4 mm.4. The container for containing a liquid according to claim 1 , wherein the inner wall consists of plastic.5. The container for containing a liquid according to claim 4 , wherein said plastic comprises materials from the group polyamide claim 4 , in particular PA 6.6 or PA 12 claim 4 , cyclic olefin copolymers (COC) claim 4 , polypropylene and/or polyethylene.6. The container for containing a liquid according to claim 1 , wherein the inner wall consists of glass.7. The container for containing a liquid according to claim 6 , wherein the glass ...

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Номер записи: 40
21-05-2015 дата публикации

UNITARY PACKAGING FOR ONE CONTAINER FILLED WITH A LIQUID PHARMACEUTICAL PRODUCT

Номер: US20150136639A1
Автор: Aranda Lopez Andres Marcelo
Принадлежит: SANOFI

The invention provides a packaging for a container () filled with a liquid pharmaceutical product and comprising a head () and a body () both made from a single piece and a neck portion () configured to form a frangible junction () between said head () and said body (), said packaging () being made from plastic material and comprising two layers () between which is defined a cavity () configured to receive said container (); wherein said packaging () is a unitary packaging which is configured to receive one container () and comprises a foldable portion () configured so that an upper portion () of said packaging () which is configured to receive said head () of said container () folds when said head () is submitted to a determined load, an access portion () provided at least around a part of said upper portion () and being remote to said foldable portion () and a protective portion () configured between said access portion () and said foldable portion (); so that when said head () of said container () is broken due to said determined load, said foldable portion () is configured to be folded, said access portion () is configured to give free access to said liquid pharmaceutical product in said body () and said protective portion () is configured to protect the access to the broken neck portion () of said container. 12435643111231821122432142427322428272442242732852. Packaging for a container () filled with a liquid pharmaceutical product and comprising a head () and a body () both made from a single piece and a neck portion () configured to form a frangible junction () between said head () and said body () , said packaging () being made from plastic material and comprising two layers ( , ) between which are defined a cavity () configured to receive said container (); wherein said packaging () is a unitary packaging which is configured to receive one container () and comprises a foldable portion () configured so that an upper portion () of said packaging () which is ...

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Номер записи: 41
19-05-2016 дата публикации

VIAL FOR FLUID PRODUCTS, PARTICULARLY FOR MEDICAL, PHARMACEUTICAL, COSMETIC, FOOD PRODUCTS OR THE LIKE

Номер: US20160137367A1
Автор: Fontana Antonio
Принадлежит: LAMEPLAST S.P.A.

The vial () for fluid products, particularly for medicinal, pharmaceutical cosmetic, food products or the like, comprises: 212513) Vial () according to claim 1 , wherein said hollow body () claim 1 , said closing cap () and said steady connection brace () are made integral in a single body piece in said initial configuration.31267) Vial () according to claim 1 , wherein said hollow body () has a longitudinal axis (L) in correspondence to which are arranged said pre-established breaking line () in said initial configuration and said outflow opening () in said opening configuration.41521267) Vial () according to claim 3 , wherein claim 3 , in the proximity of said closing cap () claim 3 , said hollow body () ends up into a neck () which extends along said longitudinal axis (L) and has said pre-established breaking line () in said initial configuration and said outflow opening () in said opening configuration.51238311) Vial () according to claim 1 , wherein said hollow body () comprises at least a substantially protruding spacing fin () which is associated along a first weakened area () with the spacing fin () of another vial () arranged adjacent to form a strip (S) of vials ().6159511) Vial () according to claim 1 , wherein said closing cap () is associated along a second weakened area () with the closing cap () of another vial () arranged adjacent to form a strip (S) of vials ().71131210) Vial () according to claim 4 , wherein said steady connection brace () has an extremity associated with said neck () and the opposite extremity associated with said substantially sheet-shaped portion ().8113310) Vial () according to claim 5 , wherein said steady connection brace () has an extremity associated with said spacing fin () and the opposite extremity associated with said substantially sheet-shaped portion ().9151471) Vial () according to claim 1 , wherein said closing cap () comprises at least a clogging element () which can be inserted in said outflow opening () to ...

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Номер записи: 42
17-05-2018 дата публикации

PROCESS OF PRODUCING GLASS VESSEL

Номер: US20180134603A1
Автор: Inoue Yoshio
Принадлежит: NIPRO CORPORATION

There is provided a means which carries out a fire-blast treating effectively upon removing a deteriorated region caused by processing in a process of producing a glass vessel. In a process of producing a glass vessel by fire-blast treating an internal surface of a preform of the glass vessel with a flame from a burner so as to produce the glass vessel, said fire-blast treating is carried out such that a temperature of an outer surface portion of the preform which portion is opposed to the deteriorated region caused by processing is between 650° C. and 800° C. when the flame is scanned along the internal surface of the preform toward an opening of the preform. 1. A process of producing a glass vessel by fire-blast treating an internal surface of a preform of the glass vessel with a flame from a burner so as to produce the glass vessel , characterized in thatsaid fire-blast treating is carried out such that a temperature of an outer surface portion of the preform which portion is opposed to a deteriorated region of the preform caused by processing is between 650° C. and 800° C. when the flame is scanned along the internal surface of the preform toward an opening of the preform.2. The process of producing the glass vessel according to characterized in that the fire-blast treating is carried out by scanning claim 1 , with the flame toward the opening of the preform claim 1 , an internal surface portion of the preform in a belt like region which is located at a height between 8% and 16% of a total height of the preform from a bottom of the preform based on an external dimension of the preform.3. A process of producing a glass vessel by fire-blast treating an internal surface of a preform of the glass vessel with a flame from a burner so as to produce the glass vessel claim 1 , characterized in thatsaid fire-blast treating is carried out by scanning, with the flame toward an opening of the preform, an internal surface portion of the preform in a belt like region which is ...

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Номер записи: 43
28-05-2015 дата публикации

STICK PACK POUCH PACKAGING

Номер: US20150144518A1
Автор: Mathew Sabu, Plezia Mark A., Shorts Raymond Scott
Принадлежит:

A stick pack pouch package comprising a foil sheet having side edges and first and second edges extending transversely between the side edges, a longitudinal sealing joint extending between the side edges to form the foil sheet into a tube, wherein the tube has a front side and a back side, and wherein the longitudinal sealing joint is on the back side, first and second transverse sealing joints sealing the first and second edges, respectively, a weakened pattern which extends over/across at least a portion of the longitudinal sealing joint, the back side of the tube, and the front side of the tube, wherein the weakened pattern enables the package to be opened along the pattern and wherein the weakened pattern includes nonlinear portions on the front side, back side, or front and back sides of the tube. 1. A stick pack pouch package comprising:a foil sheet having side edges and first and second edges extending transversely between the side edges,a longitudinal sealing joint extending between the side edges to form the foil sheet into a tube, wherein the tube has a front side and a back side, and wherein the longitudinal sealing joint is on the back side,first and second transverse sealing joints sealing the first and second edges, respectively,a weakened pattern which extends over/across at least a portion of the longitudinal sealing joint, the back side of the tube, and the front side of the tube, wherein the weakened pattern enables the package to be opened along the pattern and wherein the weakened pattern includes nonlinear portions on the front side, back side, or front and back sides of the tube.2. The package of claim 1 , wherein the weakened pattern is in the shape of a spout.3. The package of claim 2 , wherein the spout aids the pouring of product out of the package.4. The package of claim 1 , wherein the package is opened from the longitudinal sealing joint.5. The package of claim 1 , wherein the package is opened from a left or a right side of the tube.6. ...

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Номер записи: 44
30-04-2020 дата публикации

CONTAINER PRECURSOR HAVING A WALL OF GLASS WHICH IS SUPERIMPOSED BY A PLURALITY OF PARTICLES

Номер: US20200130892A1
Автор: Anton Andrea, Heinricht Frank, Mangold Stephanie, Rudigier-Voigt Eveline
Принадлежит: SCHOTT AG

Container precursors are provided that have a wall of glass. The wall of glass at least partially encloses an interior volume. The wall of glass has a side that faces away from the interior volume. The side is at least partially superimposed by a plurality of particles. An arrangement is also provided that includes a packaging and a multitude of the container precursors. A process for preparing a functionalised container precursor is also provided. A process for packaging pharmaceutical compositions and closed containers obtainable by this process are provided. 1. A container precursor comprising:a wall of glass at least partially enclosing an interior volume; anda plurality of particles at least partially superimposing a side of the wall of glass that faces away from the interior volume.2. The container precursor of claim 1 , wherein the plurality of particles superimposes at least 10% of the side of the wall of glass that faces away from the interior volume.3. The container precursor of claim 1 , wherein the plurality of particles superimposes 1 to 50% of the side of the wall of glass that faces away from the interior volume.4. The container precursor of claim 1 , wherein the side of the wall of glass that faces away from the interior volume has a coefficient of dry sliding friction of less than 0.25.5. The container precursor of claim 1 , wherein the plurality of particles is across between at least 10% and a full surface area of the side of the wall of glass that faces away from the interior volume.6. The container precursor of claim 1 , wherein the side of the wall of glass that faces away from the interior volume has a contact angle for wetting with water of 0 to 45°.7. The container precursor of claim 1 , wherein the wall of glass comprises a side that faces the interior volume that is not superimposed by any of the plurality of particles.8. A container comprising:a wall of glass that forms a hollow glass body at least partially enclosing an interior volume, ...

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Номер записи: 45
02-06-2016 дата публикации

AMPOULE FOR A MEDICAL LIQUID, AND METHOD FOR PRODUCING AN AMPOULE

Номер: US20160151240A1
Автор: Brandenburger Torsten
Принадлежит: FRESENIUS KABI DEUTSCHLAND GmbH

An ampoule for a medical liquid, comprising an ampoule body for receiving a medical liquid and a connection part for connecting a removal device to the ampoule. The ampoule body is produced as a plastic injection-molded part by means of a plastic injection molding process. In this manner an ampoule is provided which allows a simple and inexpensive production of the ampoule and can ensure a sterile storage of medical liquids. 2. The ampoule as claimed in claim 1 , wherein the ampoule is of a multi-part construction claim 1 , with the connection part being joined as a separate part to the ampoule body claim 1 , in particular with the connection part being held with a form fit on a neck of the ampoule body.3. The ampoule as claimed in claim 1 , wherein the connection part has a threaded segment with at least one thread turn for producing a threaded connection to a removal device and has a break-off piece connected to the threaded segment claim 1 , wherein the break-off piece claim 1 , in a state when connected to the threaded segment claim 1 , closes an opening of the ampoule body and claim 1 , in order to free the opening claim 1 , is removable from the threaded segment.4. The ampoule as claimed in claim 3 , wherein the threaded segment and the break-off piece are designed in one piece claim 3 , wherein a predetermined breaking point for breaking the break-off piece from the threaded segment is arranged between the threaded segment and the break-off piece.5. The ampoule as claimed in claim 1 , wherein a membrane element for sealing a transition between the ampoule body and the connection part is arranged between the ampoule body and the connection part.6. The ampoule as claimed in claim 1 , wherein the ampoule body is flexible claim 1 , in such a way that it is collapsible when a medical liquid is removed from the ampoule body.7. The ampoule as claimed in claim 1 , wherein the ampoule body has claim 1 , on a side facing way from the connection part claim 1 , a base ...

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Номер записи: 46
02-06-2016 дата публикации

PROCEDURE FOR THE MANUFACTURE OF VIALS FOR FLUID PRODUCTS, PARTICULARLY FOR MEDICAL, PHARMACEUTICAL, COSMETIC, FOOD PRODUCTS OR THE LIKE

Номер: US20160152359A1
Автор: Fontana Antonio
Принадлежит:

The procedure for the manufacture of vials for fluid products, particularly for medical, pharmaceutical, cosmetic, food products or the like, comprises the steps of: 1) Procedure for the manufacture of vials for fluid products , particularly for medical , pharmaceutical , cosmetic , food products or the like , wherein said procedure comprises the steps of:{'b': '1', 'claim-text': [{'b': 4', '4', '5', '6', '7', '5', '8', '9, 'at least a containment body () for at least a fluid product, said containment body () having a longitudinal direction (D), a first extremity () suitable for defining a dispensing mouth () of said fluid product and a second extremity () substantially tubular opposite said first extremity () and suitable for defining an introduction opening () of said fluid product having an edge (); and'}, {'b': 10', '6, 'at least a closing element () of said dispensing mouth ();'}], 'forming at least a vial () having{'b': 4', '6', '10, 'filling said containment body () with said fluid product with said dispensing mouth () closed by said closing element ();'}{'b': 8', '9', '16', '17', '18, 'sealing said introduction opening () by squeezing said edge () between at least two sealing elements () to define a sealed portion (, ) substantially plate-shaped;'}{'b': 21', '17', '18, 'applying information, data or logos () on said sealed portion (, ).'}2191718171817191821) Procedure according to claim 1 , wherein said sealing comprises defining at least a reinforcement rib () onto a part of said sealed portion ( claim 1 , ) claim 1 , said sealed portion ( claim 1 , ) being split up into at least a first stretch () on which is defined said reinforcement rib () and into at least a second stretch () on which said information claim 1 , data or logos () are applied.31718) Procedure according to claim 2 , wherein said first stretch () is arranged in proximal position and said second stretch () is arranged in distal position.4) Procedure according to claim 1 , wherein said ...

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Номер записи: 47
07-05-2020 дата публикации

METHOD FOR EVALUATION OF GLASS CONTAINER

Номер: US20200141878A1
Автор: LISMAN Dave
Принадлежит: NIPRO CORPORATION

The present invention provides a method for evaluating a processing deterioration level of a medical glass container, including (a) a step of imaging a surface of a medical glass container molded from a borosilicate glass tube to obtain an image, and (b) a step of analyzing a contrast of the image. The method is particularly useful to evaluate the amount of alkali substances which are deposited on the inner side surface of a medical glass container. 1. A method for evaluating a level of deterioration and silica peeling off of a glass container molded from a borosilicate glass tube , comprising:(a) a step of imaging at least a portion of a surface of the glass container to obtain its image, and(b) a step of analyzing a contrast of the image.2. The method according to claim 1 , wherein the step of imaging is performed with an optical microscope or a scanning electron microscope.3. The method according to claim 1 , wherein the step of imaging is performed with a digital optical microscope.4. The method according to claim 1 , wherein the step of imaging is performed with a digital optical microscope using a surface magnification of 200× to 500×.5. The method according to claim 1 , wherein the step of imaging the surface is performed by imaging an inner side surface or an outer side surface of the glass container.6. The method according to claim 1 , wherein the step of imaging the surface is performed by imaging an outer side surface of the glass container.7. The method according to claim 1 , wherein the step of imaging the surface is performed by imaging an outer side surface of the glass container which side surface is about 3 to 5 mm from the heel of the container.8. The method according to claim 1 , wherein the step of imaging the surface is performed during or after manufacture of the glass container.9. The method according to claim 1 , wherein the step of imaging the surface is performed before or after annealing of the glass container.10. The method according to ...

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Номер записи: 48
09-06-2016 дата публикации

SYRINGE FOR AND METHOD OF DELIVERING A VOLUME OF SOLUTION

Номер: US20160158101A1
Автор: Latiolais Lon J.
Принадлежит:

Methods and apparatuses are disclosed with regard to syringe-transfer of a solution or other fluid within a carpule. One embodiment includes an apparatus that is a non-standard carpule barrel having a top portion, a bottom portion, and a barrel portion therebetween. The top portion includes an opening for receiving a syringe plunger and at least a first portion of a connection mechanism for connecting to an upper portion of the syringe. The bottom portion includes another opening capable of holding a bottom end of the carpule, wherein the carpule may be a standard carpule or a non-standard carpule. The barrel portion is located between the top portion and bottom portion, wherein the barrel portion includes a cradle, and wherein the cradle has a length capable of holding a standard carpule or a non-standard carpule and a width greater than the standard carpule. 1. A method of transferring a fluid , the method comprising:applying a force to a syringe plunger, wherein the force causes the syringe plunger to forcibly connect to a non-standard carpule loaded into an interchangeable barrel of a syringe, and wherein the non-standard carpule comprises a volume of the fluid that is different from the volume of the fluid within a standard carpule;moving, subsequent to the applying, the fluid through a syringe needle in fluid communication with the non-standard carpule; andadjusting, subsequent to the moving, the volume of the fluid in the non-standard carpule using the force.2. The method of claim 1 , wherein the applying comprises pushing down on the syringe plunger for connecting to the non-standard carpule claim 1 , pushing down on the syringe plunger for inserting into the non-standard carpule claim 1 , or combinations thereof.3. The method of claim 1 , further comprising applying the force in relation to the syringe plunger claim 1 , wherein the force comprises pulling up on the syringe plunger in order to at least partially fill the non-standard carpule with the fluid.4 ...

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Номер записи: 49
09-06-2016 дата публикации

SYRINGE FOR AND METHOD OF DELIVERING A VOLUME OF SOLUTION WITH GUIDANCE BEARING IN VIEW OF STANDARD AND NON-STANDARD CARPULES

Номер: US20160158447A1
Автор: Latiolais Lon J.
Принадлежит:

Methods and apparatuses are disclosed with regard to syringe-transfer of a solution or other fluid, optionally with a guidance bearing, within a standard or non-standard carpule, optionally having sealed top ends and measurement gradations, i.e., indicia. One embodiment is a non-standard carpule barrel having a top portion, a bottom portion, and a barrel portion therebetween. The top portion includes an opening for receiving a syringe plunger and at least a first portion for connecting to an upper portion of the syringe. The bottom portion includes another opening capable of holding a bottom end of the carpule, wherein the carpule may be a standard carpule or a non-standard carpule. The barrel portion is located between the top portion and bottom portion, and includes a cradle, which has a length capable of holding a standard or a non-standard carpule, which has a greater width than a standard carpule. 1. A non-standard carpule barrel comprising:a top portion comprising an opening for receiving a syringe plunger and at least a first portion of a connection mechanism for connecting to an upper portion of a syringe;a bottom portion comprising another opening capable of holding a bottom of a carpule, a section of a syringe needle, or combinations thereof, wherein the carpule comprises a removable standard carpule or a removable non-standard carpule; anda barrel portion located between the top portion and the bottom portion, wherein the barrel portion comprises a cradle, wherein the cradle has a length capable of holding the removable standard carpule or the removable non-standard carpule, and a width greater than the removable standard carpule.2. The non-standard carpule barrel of claim 1 , further comprising an integrated or removable plug for sealing a cavity located at a top end of the removable non-standard carpule.3. The non-standard carpule barrel of claim 1 , wherein the non-standard carpule barrel is optionally removable from a portion of a syringe.4. The non- ...

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Номер записи: 50
23-05-2019 дата публикации

FILING SYSTEM AND METHODS FOR ASEPTIC CARTRIDGE AND DISPENSER ARRANGEMENT

Номер: US20190151194A1
Автор: Genosar Amir
Принадлежит:

A package for use with a beneficial agent delivery device. The package includes at least one filling chamber having a sealed penetrable access region, at least one compartment configured to hold a content, wherein the content includes at least one of a beneficial agent or a constituent of a beneficial agent, and at least one channel connecting the at least one filling chamber in fluid communication with the at least one compartment. At least a portion of the package is resealable to contain the content. 1. A package for use with a beneficial agent delivery device , said package comprising:at least one filling chamber having a sealed penetrable access region;at least one compartment configured to hold a content, wherein the content includes at least one of a beneficial agent or a constituent of a beneficial agent; andat least one channel connecting the at least one filling chamber in fluid communication with the at least one compartment;wherein at least a portion of the package is resealable to contain the content.2. The package of claim 1 , further comprising a delivery member operable to remove at least some of the content from the at least one compartment.3. The package of claim 2 , wherein the delivery member is operable between a retracted position and a delivery position.4. The package of claim 1 , wherein the at least one filling chamber comprises a plurality of filling chambers.5. The package of claim 1 , wherein at least one of the filling chambers is configured for filling the at least one compartment.6. The package of claim 1 , wherein at least one of the filling chambers is configured for removing content from the at least one compartment.7. The package of claim 1 , wherein the at least one compartment comprises a plurality of compartments.8. The package of claim 7 , wherein the plurality of compartments are separated by at least one frangible seal.9. The package of claim 1 , wherein the at least one channel comprises a plurality of channels.10. The ...

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Номер записи: 51
23-05-2019 дата публикации

CONTAINER FOR A LIQUID MEDICAMENT

Номер: US20190151198A1
Автор: Juhnke Hanno, Schrack Michael, Spengler Jan-Peter
Принадлежит:

The present disclosure relates to a container for a liquid medicament, comprising at least one flexible casing forming at least one cavity configured to receive the medicament, wherein the casing comprises a first wall portion and a second wall portion, wherein the second wall portion is located opposite to the first wall portion, at least a first outlet in fluid connection with the cavity and extending through the casing and multiple filaments extending through the cavity wherein each of the multiple filaments comprises a first end and a second end, wherein the second end is opposite to the first end, and wherein each of the first ends of the filaments are connected to the first wall portion and each of the second ends of the filaments are connected to the second wall portion. 115-. (canceled)16. A container for a liquid medicament , the container comprising:at least one flexible casing forming at least one cavity configured to receive the medicament, wherein the casing comprises a first wall portion and a second wall portion, wherein the second wall portion is located opposite to the first wall portion;at least a first outlet in fluid connection with the cavity and extending through the casing; andmultiple filaments extending through the cavity, wherein each of the multiple filaments comprises a first end and a second end, wherein the second end is opposite to the first end, and wherein each of the first ends of the filaments are connected to the first wall portion and each of the second ends of the filaments are connected to the second wall portion.17. The container according to claim 16 , wherein the filaments are tension-stable.18. The container according to claim 16 , wherein the cavity is inflatable to a maximum volume and to a predefined inside pressure at least until the filaments are tensed and straight-lined.19. The container according to claim 18 , wherein each of the casing claim 18 , the first wall portion claim 18 , the second wall portion claim 18 , ...

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Номер записи: 52
28-08-2014 дата публикации

Applicator for applying a liquid to a location on a body

Номер: US20140243756A1
Автор: Daniel M. BROBERG, Kevin Connelly, Kevin D. Mcintosh, Zachary W. MILLER
Принадлежит: Summit Medical Inc

An applicator for administering a liquid to a selected location of a patient includes a main body having an interior cavity and a flexible outer wall. A frangible ampoule is configured to contain the liquid and configured to be positioned within the interior cavity of the main body. A hypodermic tube having a proximal end attached to the main body and a distal end. An applicator tip attached to the distal end of the hypodermic tube to dispense the liquid.

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Номер записи: 53
01-07-2021 дата публикации

Metering device

Номер: US20210196573A1
Автор: Ingmar Wellach
Принадлежит: Individual

A metering device for a drinking vessel for dispensing a liquid from the drinking vessel, with a control device which detects and/or controls the delivery of the liquid. Furthermore, the invention relates to a drinking bottle having such a metering device. The drinking bottle is particularly suitable for administering a Levodopa suspension for the high-frequency treatment of idiopathic Parkinson's disease.

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Номер записи: 54
21-06-2018 дата публикации

VIAL WITH INTERGRATED NEEDLESS ACCESS PORT

Номер: US20180168929A1
Автор: Quinones Julian, Stone Jason
Принадлежит:

A needleless access vial includes a vial body for storing a liquid medication. A needleless access port is disposed within an opening along the top of the vial body. A valve having a deformable body is positioned within the access port housing, and is in communication with the access port inlet section and the access port outlet section. The valve is biased toward a closed configuration, and transitions to an open configuration upon engagement of the outlet section by a needleless syringe. 1. A medicinal vial for dispensing liquid medication to a needleless syringe having a tip and a threaded shield , said comprising:a vial body having a bottom end, a continuous outer wall, a hollow interior space, and an opening that is in communication with the hollow interior space;an access port housing that includes an inlet section disposed within the hollow interior space, an outlet section that is disposed above the opening, and a cap that is permanently sealed along the opening; anda valve that is positioned within the access port housing, and is in communication with each of the inlet section and the outlet section, said valve functioning to transition between an open configuration for allowing access to the hollow interior space, and a closed configuration for preventing access to the hollow interior space.2. The vial of claim 1 , further comprising:a plurality of threaded elements that are disposed along an outside portion of the outlet section, said outlet section and said threaded elements including a shape and size that are configured to engage the threaded shield of the needleless syringe;3. The vial of claim 2 , wherein said valve comprises:a deformable body having a tip member that is disposed within an opening along the outlet section,wherein in the closed configuration, the tip member is flush with the opening forming a seal, andin the open configuration, the tip of the needleless syringe is positioned within the opening of the outlet section, and the tip member ...

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Номер записи: 55
28-05-2020 дата публикации

METHOD OF BLOW MOULDING, FILLING AND CLOSING, AND CONTAINER PRODUCT, ESPECIALLY AMPOULE PRODUCT, PRODUCED THEREBY

Номер: US20200164563A1
Автор: GESER Johannes, GROH Martin, SPALLEK Michael
Принадлежит:

A blow molding, filling and closing process and container product produced accordingly, in particular an ampoule product. 1. A blow molding , filling and closing process for producing a filled and closed container product that can be stored as well , in particular in the form of an ampoule product which is formed from a plastic material and has a single-layer container wall or ampoule wall and which , during initial use , permits the withdrawal , in particular for an oral use of the product content , by opening at least one withdrawal opening for withdrawal purposes , characterized in that plastic materials suitable for the process are selected which are tasteless and/or odorless or essentially tasteless and/or odorless in interaction with the contents of the container before and during use and which retain this tastelessness and/or odorlessness even after prolonged storage.2. The process according to claim 1 , characterized in that aromatic polyester polymers and/or polyester copolymers and/or blends of these materials are used as plastic materials for the products to be produced.3. The process according to claim 1 , characterized in that temperatures in the range from 250° C. to 280° C. can be selected as processing temperatures for the aromatic polyester polymers and their intrinsic viscosities during processing can be selected to be 0.6 dl/g to 1.7 dl/g.4. The process according to claim 1 , characterized in that the water content of the plastic granulate in the manufacturing process for specifically selected aromatic polyester polymers and/or copolymers immediately prior to extrusion is selected to be less than 50 ppm claim 1 , preferably 30 ppm.5. The process according to claim 1 , characterized in that 10% to 80% claim 1 , preferably 30% to 60% reclaimed material is added to the aromatic polyester polymers used.6. The process according to claim 1 , characterized in that at least partially apolyethylene naphthalate (PEN),polyethylene furanoate (PEF)polyester ...

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Номер записи: 56
16-07-2015 дата публикации

Ampoule system with medical liquid and cap with filter facility

Номер: US20150196457A1
Автор: Edgar WÜST
Принадлежит: HERAEUS MEDICAL GMBH

An ampoule system comprising an ampoule ( 1 ) made of glass and enclosing an internal space, the ampoule having an ampoule body ( 4 ) and an ampoule head ( 5 ) that can be broken off from the ampoule body ( 4 ) to open up the internal space, the internal space of the ampoule ( 1 ) containing a liquid ( 7 ) for a medical application or for producing a mixture for a medical application, wherein the ampoule system comprises a cap ( 2 ) that can be plugged onto the ampoule body ( 4 ) such that the opening of the internal space from the ampoule head ( 5 ) being broken off is covered by the cap ( 2 ), and the cap ( 2 ) comprises a filter facility ( 3 ), whereby the filter facility ( 3 ) is at least one sieve ( 3 ) and/or at least one filter and the liquid ( 7 ) can be poured through the filter facility ( 3 ) from the internal space from the ampoule ( 1 ).

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Номер записи: 57
30-07-2015 дата публикации

Squeezable Ampule with Breakable Seal in Nose Bleed Kit

Номер: US20150209228A1
Автор: Bruce Merle, Dull Lawrence
Принадлежит:

A single-use module is used to stem nose bleeds. A porous dressing, such as a moldable polymer, has a size that allows the dressing, when dry, to be easily inserted into a nostril. The dressing expands when wetted. In one embodiment, a squeezable ampule contains a single dose of a vaso-constrictor solution. A narrowed tip of the ampule has a thin wall that is broken when the ampule is squeezed with sufficient force. The dressing has a center hole into which the tip of the ampule is inserted. When a nose bleed is sensed, the dressing is quickly inserted into a nostril, and the ampule is squeezed to release the vaso-constrictor solution into the middle of the dressing. The solution is thus distributed along the length of the dressing from the inside out while the dressing is in the nostril. The ampule is then removed. 1. A dispenser for dispensing a fluid comprising:a flexible ampule having a narrowed tip, the flexible ampule containing a fluid to be dispensed; anda solid wall formed at the tip, the wall being a weakest point of the dispenser so that, when the container is squeezed by a user, the wall is broken and the fluid escapes through the broken wall.2. The dispenser of where an amount of the fluid in the ampule is only that needed for a one-time use of the ampule.3. The dispenser of wherein the wall and ampule are formed of the same material and are integral.4. The dispenser of wherein the ampule and wall are co-molded.5. The dispenser of wherein the ampule is molded claim 1 , the wall is pre-formed prior to molding the ampule claim 1 , and the wall is placed in a mold while molding the ampule so as to be secured in place at the tip of the ampule.6. The dispenser of wherein the ampule holds 1-3 milliliters of the fluid claim 1 , and the wall is a polymer having a thickness less than 3 mils.7. The dispenser of wherein the ampule is configured to be squeezed between the thumb and index finger of the user.8. The dispenser of wherein the fluid is a single dose of a ...

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Номер записи: 58
25-06-2020 дата публикации

AUTOINJECTOR APPARATUS

Номер: US20200197626A1
Автор: Denzer Michael, Ewing Kenneth R., Ganzitti Gabriele, Johnston Neal, Krishna Suhas, Swift Robert W.
Принадлежит:

An autoinjector apparatus is disclosed which comprises a single-use cassette and an autoinjector. The cassette comprises a housing and a sleeve movably disposed in the housing. A syringe may be disposed in the sleeve and secured therein with a lock cap. The lock cap is affixed to a distal end of the sleeve and contacts the distal end of the syringe. A shield remover extends through an opening in a proximal end of the housing for removing a needle shield which covers a needle of the syringe. A cassette identification arrangement is provided on a surface of the housing to enable the autoinjector to identify the cassette. The autoinjector is provided with a detector for reading the cassette identification arrangement. 1. An apparatus for injection of a therapeutic product , the apparatus comprising:a cassette which conceals a syringe containing the therapeutic product; and a needle insertion and product extrusion drive arrangement; and', 'a door, movable between an open position, which allows insertion therein of the cassette, and a closed position, which allows alignment between the cassette and the needle insertion and product extrusion drive arrangement., 'an autoinjector comprising2. The apparatus of claim 1 , wherein the cassette includes a mechanical structure that facilitates insertion of the cassette into the door in a correct orientation.3. The apparatus of claim 1 , wherein the cassette includes indicia for facilitating insertion of the cassette into the door in a correct orientation.4. The apparatus of claim 1 , wherein the cassette door includes indicia for indicating an insertion entry point for the cassette.5. The apparatus of claim 1 , wherein the door includes indicia for indicating an insertion entry point for the cassette.6. An autoinjector for injecting a therapeutic product contained within a syringe claim 1 , the syringe concealed within a cassette claim 1 , the autoinjector comprising:a motorized needle insertion and therapeutic product extrusion ...

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Номер записи: 59
04-07-2019 дата публикации

CONTAINER FOR FLUID PRODUCTS, PARTICULARLY FOR MEDICAL PRODUCTS, PHARMACEUTICALS, COSMETICS, FOOD OR THE LIKE

Номер: US20190201287A1
Автор: Salvarani Enrico
Принадлежит: LAMEPLAST S.P.A.

The container () for fluid products, particularly for medical products, pharmaceuticals, cosmetics, food or the like, comprises: 21111) Container () according to claim 1 , wherein said container () comprises at least two flap elements ().31112113) Container () according to claim 1 , wherein in said initial configuration said flap elements () are arranged substantially transversely to a longitudinal axis (L) passing through said hollow body () claim 1 , and in said final configuration said flap elements () are associated with each other on opposite sides with respect to said neck ().41112021) Container () according claim 1 , wherein claim 1 , in said final configuration claim 1 , said flap elements () are associated with each other by interposition of hooking means ( claim 1 , ) adapted to join flush outer surfaces thereof.512021201121112011) Container () according to claim 4 , wherein said hooking means ( claim 4 , ) comprise at least a tooth element () associated with one of said flap elements () claim 4 , and at least a housing seat () formed on the other flap element () and adapted to house said tooth element () to lock said flap elements () in said final configuration.611149111) Container () according to claim 1 , wherein said container () comprises at least a folding line () formed on said attachment portion () claim 1 , substantially parallel to a holding plane of said container () and adapted to allow the passage claim 1 , as a result of the application of forces claim 1 , of said flap elements () from said initial configuration to said final configuration.711562) Container () according to claim 1 , wherein said container () comprises at least a gripping tab () defined as protruding from a lateral surface () of said hollow body ().8157511) Container () according to claim 7 , wherein said gripping tab () is associated along a first weakened area () with the gripping tab () of another container () arranged adjacent to form a strip (S) of containers (). ...

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Номер записи: 60
04-07-2019 дата публикации

AUTOINJECTOR APPARATUS

Номер: US20190201632A1
Автор: Denzer Michael, Ewing Kenneth R., Ganzitti Gabriele, Johnston Neal, Krishna Suhas, Swift Robert W.
Принадлежит:

An autoinjector apparatus is disclosed which comprises a single-use cassette and an autoinjector. The cassette comprises a housing and a sleeve movably disposed in the housing. A syringe may be disposed in the sleeve and secured therein with a lock cap. The lock cap is affixed to a distal end of the sleeve and contacts the distal end of the syringe. A shield remover extends through an opening in a proximal end of the housing for removing a needle shield which covers a needle of the syringe. A cassette identification arrangement is provided on a surface of the housing to enable the autoinjector to identify the cassette. The autoinjector is provided with a detector for reading the cassette identification arrangement. 1. A single-use cassette for use with an autoinjector , the cassette comprising:a housing;an inner sleeve disposed in the housing and movable between first and second positions,a syringe disposed in the inner sleeve; anda lock cap for securing the syringe in the inner sleeve, the lock cap including an elastomeric bumper, the lock cap affixed to a distal end of the inner sleeve with the elastomeric bumper contacting a distal end of the syringe, wherein the distal end of the inner sleeve comprises at least one receptacle and the lock cap comprises at least one arm member for inserting into the receptacle.23-. (canceled)4. The cassette of claim 1 , wherein the at least one arm member of the lock cap comprises a barb arrangement for gripping an inner surface of the receptacle of the inner sleeve.5. (canceled)6. The cassette of claim 1 , wherein the cassette further comprises a shield remover extending through an opening in a proximal end of the housing for removing a needle shield from the syringe claim 1 , wherein the shield remover comprises a spring-biased tab claim 1 , the tab disposed within an aperture defined in a wall of the housing.7. (canceled)8. The cassette of claim 6 , wherein the shield remover comprises an elongated body having a proximal end ...

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Номер записи: 61
04-08-2016 дата публикации

Ampoule for medical liquid and method for producing an ampoule

Номер: US20160220444A1
Автор: Christian Ebert, Ismael Rahimy, Torsten Brandenburger
Принадлежит: FRESENIUS KABI DEUTSCHLAND GmbH

An ampoule for a medical liquid comprises an ampoule body for accommodating a medical liquid and a connection part for connecting a removal device to the ampoule, which connection part extends in a longitudinal extension direction and adjoins the ampoule body. The connection part and the ampoule body are formed as one piece and the connection part has a threaded segment having at least two thread turns arranged thereon, which are axially offset from each other in the longitudinal extension direction. The ampoule enables simple attachment of a removal device, creates a tight transition between a connection part and the removal device, is simple and economical to produce, and can provide a defined attachment state for the removal device on the ampoule.

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Номер записи: 62
23-10-2014 дата публикации

PACKAGE SYSTEM FOR STERILIZING AND STORING CYANOACRYLATE ADHESIVE COMPOSITIONS

Номер: US20140311941A1
Автор: Ruiz, SR. Rafael, Zhang Sheng
Принадлежит: Adhezion Biomedical, LLC

Package systems that provide for prolonged shelf stability of sterilized cyanoacrylate compositions are provided. The package systems include an ampoule made from a material that is substantially impervious to gas and moisture penetration that includes a frangible foil seal, and an overpack. The ampoule contains a stabilized cyanoacrylate monomer composition, and may be sterilized by irradiation without substantially altering the viscosity of the composition. The package may be sterilized by ethylene oxide without substantially further altering the viscosity of the composition. The sterilized composition, when contained within the package system, is shelf-stable for a period of at least 24 months. 1. A twice-sterilized package system including a stabilized cyanoacrylate monomer composition , the package system comprising:an ampoule having sidewalls comprised of a material that is substantially impermeable to gas and substantially impermeable to moisture, which sidewalls surround a chamber containing a stabilized cyanoacrylate monomer composition comprising an amount of a free radical polymerization inhibitor and an anionic polymerization inhibitor effective to stabilize the cyanoacrylate monomer, and optionally, a polymerization accelerator mixed together with the cyanoacrylate monomer, which chamber comprises an opening that is sealed with a foil seal comprising a plurality of layers, wherein the ampoule containing the stabilized cyanoacrylate monomer composition has been sterilized by irradiation, thereby producing an ampoule containing a sterilized, stabilized cyanoacrylate monomer composition, and the sterilized, stabilized composition has a viscosity of about 3 cPs to about 12 cPs; andan overpack, which is substantially permeable to gas, having a front wrapper and a back wrapper that are sealed together around the ampoule thereby housing the ampoule containing the sterilized, stabilized cyanoacrylate monomer composition, wherein the overpack housing the ampoule ...

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Номер записи: 63
11-08-2016 дата публикации

Formulation, Apparatus and Method for Stabilizing Radiopharmaceuticals

Номер: US20160228585A1
Автор: Gangadharmath Umesh, Kolb Hartmuth C., Mocharla Vani P., Mu Fanrong, Walsh Joseph C.
Принадлежит:

A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent. 1. An apparatus for stabilizing a radiopharmaceutical , the apparatus comprising: a F18 labelled radiopharmaceutical, or a pharmaceutically acceptable salt of a F-18 labelled radiopharmaceutical thereof;', 'a gas comprising oxygen, wherein the oxygen is present in the gas in an amount of at least about 10 vol. % by total volume of gas, and where the gas is disposed in a headspace of a vial containing the F-18 labelled radiopharmaceutical or the pharmaceutically acceptable salt of the F-18 labelled radiopharmaceutical; and', 'an alcohol., 'a formulation comprising, 'a container having2. The apparatus of claim 1 ,wherein the formulation comprises an aqueous solution.3. The apparatus of claim 1 ,wherein the container is a vial.4. The apparatus of claim 1 ,wherein the container is a syringe.5. The apparatus of claim 1 ,wherein the container is sealable and when sealed, is substantially impervious to oxygen.6. The apparatus of claim 1 ,wherein the headspace is between a boundary of the formula and a boundary of the container, wherein the headspace is substantially filled with the oxygen.7. The apparatus of claim 1 ,wherein the formula further comprises ethanol.8. The apparatus of claim 1 ,wherein the formula further comprises aqueous phosphate in an amount of about 92 vol. % per total volume of liquid.9. The apparatus of claim 1 , further comprisinga stabilizer.10. The apparatus of claim 1 ,wherein the stabilizer is maleic acid.11. The apparatus of claim 9 ,wherein the stabilizer is an excipient compatible for human injection.12. The apparatus of claim 1 ,wherein the alcohol is present in an amount of about 1 volume percent to 10 volume percent based on the total volume of liquid.13. The apparatus of claim 1 ,wherein the formulation comprises a solvent.14. The apparatus of ...

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Номер записи: 64
27-08-2015 дата публикации

CD20- AND EGFR-BINDING PROTEINS WITH ENHANCED STABILITY

Номер: US20150239977A1
Автор: AGRAWAL Neeraj Jagdish, Schneider Curtiss Paul, Trout Bernhardt Levy
Принадлежит: Massachusetts Institute of Technology

The invention provides CD20-binding proteins and EGFR-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided. 1. A CD20-binding protein comprising:{'sub': 3', '10', '59', '153, 'a light chain domain having an amino acid sequence of SEQ ID NO:1 modified to include at least one amino acid substitution selected from the group consisting of: a neutral polar amino acid at V, a neutral polar amino acid at 9, a neutral polar amino acid at I, a neutral polar amino acid at Vand a negatively charged polar amino acid at L; and/or'}{'sub': 101', '178, 'a heavy chain domain having an amino acid sequence of SEQ ID NO:2 modified to include an amino acid substitution selected from the group consisting of a neutral polar amino acid at Yand a neutral polar amino acid at L; and/or'}{'sub': 15', '33', '62', '89, 'an Fc domain having an amino acid sequence of SEQ ID NO:3 modified to include at least one amino acid substitution selected from the group consisting of: a positive polar amino acid at position L, a positive polar amino acid at position I, a positive polar amino acid at position V, and a positive polar amino acid at position L.'}2. The CD20-binding protein of claim 1 , wherein the protein comprises a light chain domain having an amino acid sequence of SEQ ID NO:1 modified to include at least two claim 1 , at least three claim 1 , at least four claim 1 , or at least five amino acid substitutions selected from the group consisting of: a neutral polar amino acid at V claim 1 , a neutral polar amino acid at 9 claim 1 , a neutral polar amino acid at I claim 1 , a neutral polar amino acid at V claim 1 , and a negatively charged polar amino acid at L.3. The CD20-binding protein of or claim 1 , wherein the neutral polar amino acid at V claim 1 , 9 claim 1 , Iand Vof SEQ ID NO:1 and at Yand Lof SEQ ID NO:2 is selected from the group consisting of: asparagine (N) claim 1 , cysteine (C) claim 1 , glutamine (Q) claim 1 , histidine (H) ...

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Номер записи: 65
16-08-2018 дата публикации

Surgical Adhesive Including Honey and Methods of Preparation and Use Thereof

Номер: US20180228935A1
Автор: Leyendecker Peyton M
Принадлежит:

A mixture of honey solution and a surgical adhesive, typically a cyanoacrylate adhesive is described. The adhesive and honey solution are mixed and applied to a cut or wound prior to the cure of the mixture. The adhesive mixture, which retains the strength of the unadulterated adhesive significantly reduces the growth of bacteria in the vicinity of the associated closed cut or wound, has applicability in both human and veterinary medicine. 1. A mixture comprising a cyanoacrylate adhesive and honey solution.2. The mixture of claim 1 , wherein the adhesive is a n-Butyl-2 Cyanoacrylate adhesive.3. The mixture of claim 1 , wherein honey in the honey solution is a Manuka Honey.4. The mixture of claim 1 , wherein honey in the honey solution has a Kfactor of at least 10.5. The mixture of claim 1 , wherein honey in the honey solution has a Kfactor of at least 15.6. The mixture of claim 1 , wherein the honey solution comprises two thirds honey to one third water by weight.7. The mixture of claim 1 , wherein the ratio of honey solution to adhesive by volume is between 20:80 and 80:20.8. A combination comprising packaging claim 1 , honey solution claim 1 , and cyanoacrylate adhesive claim 1 , wherein the packaging includes (a) a first sealed chamber containing the honey solution and (b) a second sealed chamber containing cyanoacrylate adhesive claim 1 , the two chambers being distinct and not in fluid communication with each other.9. The combination of claim 8 , wherein the packaging comprises a dual chamber syringe claim 8 , wherein each chamber includes a plunger end and a dispensing end.10. The combination of claim 8 , wherein the packaging a flexible packet.11. The combination of claim 9 , further comprising a mixing nozzle claim 9 , the mixing nozzle adapted to operatively couple to the dispensing end of each of the first and second chambers.12. The combination of claim 10 , wherein the packet further includes a tear-off or cut-off end to provide access to the first and ...

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Номер записи: 66
25-08-2016 дата публикации

DOSING CONTAINER

Номер: US20160244203A1
Автор: Caminada Jeroen
Принадлежит: DIVERSEY, INC.

A container including a reservoir to store a dispensable material and an elongated neck that extends from the reservoir and that terminates at a distal end. The container also includes a frangible region intermediate the reservoir and the distal end of the elongated neck. The frangible region is fracturable in response to a predetermined force applied to the distal end to create opening in the elongated neck through which the material can be dispensed from the reservoir. The container further includes a guard disposed adjacent the elongated neck to inhibit inadvertent fracture of the frangible region absent the predetermined force. 1. A container comprising:a reservoir to store a dispensable material;an elongated neck extending from and fluidly connected to the reservoir;a frangible region intermediate the reservoir and a distal end of the elongated neck, the frangible region fracturable in response to a predetermined force applied to the distal end to create opening in the elongated neck through which the material may be dispensed from the reservoir; anda guard positioned on the container adjacent the frangible region to inhibit inadvertent fracture of the frangible region absent the predetermined force.2. The container of claim 1 , further comprising a passageway having a first end disposed proximate the frangible region and a second end in fluid communication with the reservoir.3. The container of claim 2 , wherein the passageway is elongated and extends from adjacent the frangible region to a bottom of the reservoir.4. The container of claim 1 , further comprising a planar backing including a first backing portion and a second backing portion laterally separated from the first backing portion by a notch.5. The container of claim 4 , wherein the elongated neck is coupled to the first backing portion claim 4 , and wherein the guard is at least partially defined by the second backing portion.6. The container of claim 1 , wherein the frangible region includes a ...

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Номер записи: 67
30-08-2018 дата публикации

BENEFICIAL AGENT DISPENSER

Номер: US20180243505A1
Автор: Genosar Amir
Принадлежит:

A dispensing device for use with a beneficial agent has a dispensing package, a dispenser disposed on an end portion of the dispensing package, and an actuator movably disposed along at least a portion of the package between a pre-dispensing state and a dispensing state. One arrangement also provides a beneficial agent dispenser having a dispensing port, an elongate portion and a plunger that is movably disposed relative to a tubular wall of the elongate portion during a dispensing stroke to partially penetrate a separable barrier and expel the beneficial agent through the dispensing port. 145-. (canceled)46. A dispensing device for use with a beneficial agent , comprising: an elongate, at least partially flexible member comprising a sealed, pre-formed tubular compartment and at least one separable barrier enclosing one end of said tubular compartment, wherein said tubular compartment includes at least a first compartment; and', 'one of a beneficial agent or a constituent of a beneficial agent contained in said tubular compartment;, 'a dispensing package, comprisinga dispenser disposed on a dispensing end portion of said dispensing package; anda pressure chamber enclosing at least a portion of said tubular compartment and configured such that elevated pressure in said pressure chamber results in expulsion of said beneficial agent or constituent of a beneficial agent from at least said tubular compartment.47. The dispensing device according to wherein said separable barrier is formed along a tubular wall of said tubular compartment by pinching said one end of said tubular compartment and thereafter sealing across said one end.48. The dispensing device according to wherein said separable barrier defines a distal end of said tubular compartment.49. The dispensing device according to wherein said separable barrier defines a proximal end of said first compartment.50. The dispensing device according to wherein said first compartment stores a first constituent of the ...

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Номер записи: 68
09-09-2021 дата публикации

APPARATUS AND MACHINE FOR MAKING CUSTOMIZED FORMULATIONS BASED ON USER INPUT

Номер: US20210279600A1
Автор: Hudson Edison Thurman, Noel Lloyd Staton
Принадлежит:

The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested. 1 receive health-related information from an individual;', 'receive taste-related preference data from a individual;', 'based on the health-related information, determine a suggested formulation for a supplement for the individual;', 'based on the taste-related preference data, determine a suggested filler medium;', 'receive individual alterations to each of the suggested formulation and suggested filler medium., 'a computing device configured to. A system comprising: This application is a continuation of U.S. patent application Ser. No. 15/688,994 filed on Aug. 29, 2017, entitled “APPARATUS AND MACHINE FOR MAKING CUSTOMIZED FORMULATIONS BASED ON USER INPUT”, which is a continuation of U.S. patent application Ser. No. 15/620,915 filed on Jun. 13, 2017, entitled “METHOD AND SYSTEM FOR MAKING CUSTOMIZED FORMULATIONS FOR INDIVIDUALS”, now U.S. Pat. No. 10,776,701 issued on Sep. 15, 2020, which is a divisional of U.S. patent application Ser. No. 14/207,364 filed on Mar. 12, 2014, entitled “METHOD AND SYSTEM FOR MAKING CUSTOMIZED FORMULATIONS FOR INDIVIDUALS”, now U.S. Pat. No. 9,704,096 issued on Jul. 11, 2017, which claims priority to U.S. Provisional Patent Application No. 61/777,181 filed on Mar. 12, 2013, entitled “METHOD AND SYSTEM FOR MAKING CUSTOMIZED FORMULATIONS FOR INDIVIDUALS”, the contents of all of which are hereby incorporated by reference herein.This disclosure includes a method and system for assembling a subset of multiple ...

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Номер записи: 69
22-09-2016 дата публикации

PHARMACEUTICAL RECONSTITUTION

Номер: US20160271018A1
Автор: Li Xiang, Maimon Benjamin E., Suk Ho-Jun
Принадлежит:

A device is disclosed for reconstitution and delivery of an injectable pharmaceutical. A pharmaceutical composition such as a lyophilized drug is provided in a pressurizable fluid reservoir with a pierceable seal. A diluent may be separately provided in a syringe with a needle. When the needle is driven through the seal and the plunger is actuated, fluid from the barrel of the syringe flows into the pressurizable fluid reservoir to simultaneously pressurize the reservoir and mix the diluent with the drug. Pressurized in this manner, the reservoir can then automatically and without further user intervention push the mixture back through the needle and into the barrel of the syringe, further mixing the composition and displacing the plunger to fill the barrel with the reconstituted drug. The needle and syringe can then be detached from the reservoir with the reconstituted drug contained in the barrel and ready for injection. 1. A device for reconstituting a pharmaceutical comprising:a fluid reservoir with an opening, the fluid reservoir containing a dry pharmaceutical composition;a seal forming a pierceable cover for the opening;a moving seal within the fluid reservoir; anda stored energy mechanism configured to pressurize an interior of the fluid reservoir by applying a force to the moving seal.2. The device of wherein the moving seal includes a plunger sized to slide within the interior of the fluid reservoir while maintaining a fluid seal to retain a fluid within the interior.3. The device of wherein the stored energy mechanism includes a mechanical spring.4. The device of wherein the stored energy mechanism includes a compressible fluid pressurized to apply the force to the moving seal.5. The device of further comprising a cap coupled to the stored energy mechanism and removably and replaceably coupled to the fluid reservoir claim 1 , wherein the cap is configured to engage the stored energy mechanism with the moving seal when coupled to the fluid reservoir.6. The ...

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Номер записи: 70
04-12-2014 дата публикации

Apparatus and kit for providing palliative care

Номер: US20140358059A1
Автор: Terry Parks Jones
Принадлежит: Individual

Embodiments of the invention are directed to apparatuses and kits for providing palliative care. An exemplary apparatus comprises an elongate hollow shaft having a first and a second end. An absorbent material may be attached to the first end and the first end may be perforated such that the elongate hollow shaft may be filled with one or more liquid solutions that flow through the perforated end and disperse evenly throughout the absorbent material. A kit may additionally be provided for providing customized palliative care. The kit may comprise a means for injecting one or more liquid solutions into the elongate shaft. The kit may additionally comprise apparatuses that are prefilled with one or more liquid solutions.

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Номер записи: 71
11-12-2014 дата публикации

Carpule to Store Lower Dosage Amount of Dental Anesthetic

Номер: US20140360894A1
Автор: Miles Ethel Marlene
Принадлежит:

A carpule to store lower dosage amount of dental anesthetic solution includes a tubular extrusion, a stopper, a front cap, and a color-coded band. The front cap is connected with a front opening of the tubular extrusion while the stopper is slidably engaged with a rear opening of the tubular extrusion. An inner diaphragm of the front cap is exposed through a central opening of the front cap so that the dental needle can be traversed into the tubular extrusion through the inner diaphragm. Additionally, the cross-sectional diameter of the central opening is similar to the cross-sectional diameter of the front opening so that the front cap is able to provide an expanded surface area for the dental needle to traverse through. 1. A carpule to store lower dosage amount of dental anesthetic comprises:a tubular extrusion;a stopper;a front cap;a color-coded band;the tubular extrusion comprises a front-half portion, a rear-half portion, a front opening, a rear opening, an outer annular surface, and an inner annular surface;the stopper comprises an elongated body, a first extremity, a second extremity, and a plurality of circular tabs;the front cap comprises an inner diaphragm, an outer-sealing ring, and a central opening;the front opening and the rear opening being oppositely positioned from each other along the tubular extrusion;the front cap being adjacently connected with the front opening; andthe stopper being slidably engaged with the rear opening.2. The carpule to store lower dosage amount of dental anesthetic as claimed in comprises:the front-half portion and the rear-half portion being axially positioned opposite of each other;the front opening being concentrically positioned with the front-half portion;the front opening being oppositely positioned from the rear-half portion;the rear opening being concentrically positioned with the rear-half portion; andthe rear opening being oppositely positioned from the front-half portion.3. The carpule to store lower dosage amount ...

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Номер записи: 72
29-08-2019 дата публикации

METHOD FOR PRODUCING GLASS BOTTLES WITH A LOW DELAMINATION TENDENCY UNDER THE EFFECT OF A PURGE GAS FLOW

Номер: US20190263707A1
Автор: Frost Robert, LANGE Ulrich, Moseler Doris
Принадлежит: SCHOTT AG

In a method for producing glass bottles having a flat base and an opposite filling opening, the base of the glass bottles is further formed at a plurality of processing positions. During the entire further forming of the base, with the aid of a purge gas which by way of the filling opening of the glass bottle flows in or out in a centric manner and flows out or in in an eccentric manner, a purge gas flow is generated in the interior of the glass bottle in order for delamination effects to be reduced. A tube or a nozzle serves for blowing in or suctioning out the purge gas. Various geometries and arrangements of the tube or of the nozzle are disclosed. A multiplicity of geometric constellations of the tube diameters and various mass flow settings are disclosed. 1. A method for producing glass bottles having a flat base and an opposite filling opening , the method comprising the following steps:locally heating one end of a glass tube;configuring a flange or a rolled rim having the filling opening at the locally heated end of the glass tube;severing the locally heated end of the glass tube while configuring a glass bottle having a closed base;holding the configured glass bottle upside down after severing from the glass tube; andfurther forming the base of the glass bottle, wherein in the further forming of the base of the glass bottle a purge gas flow is generated in an interior of the glass bottles with the aid of a purge gas flowing in or out in a centric manner and flowing out or in in an eccentric manner by way of the filling opening.2. The method of claim 1 , wherein the purge gas is blown into the interior of the glass bottle by way of a tube or is suctioned out of the interior of the glass bottle by way of the tube claim 1 , wherein the tube is a cylindrical tube claim 1 , and the purge gas is blown in or suctioned out by way of a front end of the tube.3. The method of claim 2 , wherein the cylindrical tube has a conically tapered external profile at the front ...

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Номер записи: 73
18-11-2021 дата публикации

LIQUID DOSAGE FORM OF EDARAVONE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF WHICH IS STABLE IN STORAGE, TRANSPORTATION AND USE

Номер: US20210353538A1
Автор: HUMENIUK Mykola Ivanovych
Принадлежит:

The invention relates to a method fr producing a liquid dosage form of the drug Edaravone for parenteral use which is stable in storage and transportation and convenient for use, which involves: preparing a solution comprising Edaravone or pharmaceutically acceptable salts thereof as the active ingredient, and excipients (an acidic component, an alkaline component, an antioxidant, an osmolar agent and/or a stabilizer); packaging said dosage form in a pre-sterilized glass bottle having a cap at least partially coated with an anti-adhesive coating; sealing the bottle with said cap at least partially coated with an anti-adhesive coating, and sterilizing the bottle containing a solution comprising Edaravone or pharmaceutically acceptable salts thereof as the active ingredient, and excipients. The invention further relates to a method for packaging a liquid dosage form of the drug Edaravone for parenteral use which is stable in storage and transportation and convenient for use, which involves: sterilizing a glass bottle having a cap; pouring a solution comprising Edaravone or pharmaceutically acceptable salts thereof as the active ingredient, and excipients (an acidic component, an alkaline component, an antioxidant, an osmolar agent and/or a stabilizer) into said sterilized glass bottle; closing (sealing) the bottle containing the solution using said cap, which is at least partially coated with an anti-adhesive coating; and sterilizing the sealed bottle containing the liquid dosage form. The invention further relates to a bottle filled with a liquid dosage form of a drug for parenteral use comprising Edaravone or pharmaceutically acceptable salts thereof as the active ingredient, and excipients (an acidic component, an alkaline component, an antioxidant, an osmolar agent and/or a stabilizer), said bottle being made of glass and being closed with a cap which is made of a material based on flexible polymers and which is at least partially coated with an anti-adhesive ...

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Номер записи: 74
28-09-2017 дата публикации

METHOD AND SYSTEM FOR MAKING CUSTOMIZED FORMULATIONS FOR INDIVIDUALS

Номер: US20170277999A1
Автор: Hudson Edison Thurman, Noel Lloyd Staton
Принадлежит:

The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested. 1 receive health-related information from an individual;', 'receive taste-related preference data from a individual;', 'based on the health-related information, determine a suggested formulation for a supplement for the individual;', 'based on the taste-related preference data, determine a suggested filler medium;', 'receive individual alterations to each of the suggested formulation and suggested filler medium., 'a computing device configured to. A system comprising: This application is a divisional application of U.S. patent application Ser. No. 14/207,364 filed on Mar. 12, 2014, which claims priority to U.S. Provisional Patent Application No. 61/777,181, filed on Mar. 12, 2013, the contents of all of which are hereby incorporated by reference herein.This disclosure includes a method and system for assembling a subset of multiple compounds into a single, edible composition. This disclosure includes a method and system for assembling multiple compounds into a single, edible composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group.There is a need for customized formulations of dietary supplements and therapeutics based on the genetic, physical, physiological, and medical needs of an individual. Conventionally, typical formulations of supplements and therapeutics are prepared as a pill or liquid in batches comprised of a fixed set of ingredients to be used by the average ...

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Номер записи: 75
27-08-2020 дата публикации

AMPOULE CLOSURE

Номер: US20200268604A1
Автор: ANDRESEN Marius, Ekroll Jan Anders, GEERS Kevin, Rasmussen Joachim Wallem, Vollen Martin
Принадлежит:

A closure for an ampoule, the closure comprising: a cap portion arranged to engage with a broken neck of an opened ampoule; and a cylindrical skirt portion extending from the cap portion, the skirt portion being elastically deformable and being arranged to move from a first position in which it is at least partially folded back on itself to a second position in which it is unfolded and extends away from the cap portion. The closure can close off an opening such as that formed in an ampoule when the neck is snapped and the top removed. As the cap portion engages with the broken neck, it reduces the chances of users receiving lacerations from the sharp edges. The cap portion also seals the ampoule, preventing the contents from being spilled and/or wasted. The closure also provides a degree of impact protection, reinforcement and strengthening to the now weakened open end of the ampoule, e.g. in case the ampoule is dropped. The skirt portion not only provides a seal around the ampoule body by being in close contact therewith, but also holds the cap portion firmly against the broken rim of the open ampoule, thus holding the closure in place by means of the friction between the skirt portion and the outer surface of the ampoule body. 1. A closure for an ampoule , the closure comprising:a cap portion arranged to engage with a broken neck of an opened ampoule; anda cylindrical skirt portion extending from the cap portion, the skirt portion being elastically deformable and being arranged to move from a first position in which it is at least partially folded back on itself to a second position in which it is unfolded and extends away from the cap portion.2. A closure as claimed in claim 1 , wherein in the first position the skirt portion is rolled back on itself.3. A closure as claimed in or claim 1 , wherein the cap portion comprises a circumferential groove in which the skirt portion sits when in the first position.4. A closure as claimed in claim 3 , wherein the distal ...

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Номер записи: 76
03-09-2020 дата публикации

CONTAINER, CONNECTION AND PRODUCTION DEVICE

Номер: US20200276081A1
Автор: BOJBIC Daniel, GESER Johannes, GIEBELER Torsten, SAUTER Roland, Schneider Sven
Принадлежит:

A container, in particular an ampule, of a plastic material having a container part () for receiving the contents of a containers () dispensed via a container opening (), which is closed by a head part () that can be separated along a separation line (,) which is adjoined by a neck part (), which has a plurality of different functional surfaces on the inner circumference, of which one functional contact surface () is used to seal against a withdrawal body (), which is provided for withdrawing the contents of a container () when the container opening () is opened, wherein in addition to the existing functional surfaces a lead-in area () is provided as a further functional surface on the interior of the neck part (), which differs geometrically from the functional contact surface (), is characterized in that the lead-in area () seamlessly merges into the functional contact surface () and that the lead-in area () and the functional contact surface are located between the other functional surfaces () in the neck part (). 1101412181620443214125040445044504420. A container , in particular an ampule , of plastic material having a container part () for receiving the contents of a containers () dispensed via a container opening () , which is closed by a head part () that can be separated along a separation line ( ,) which is adjoined by a neck part () , which has a plurality of different functional surfaces on the inner circumference , of which one functional contact surface () is used to seal against a withdrawal body () , which is provided for withdrawing the contents of a container () when the container opening () is opened , wherein in addition to the existing functional surfaces a lead-in area () is provided as a further functional surface on the interior of the neck part () , which differs geometrically from the functional contact surface () , characterized in that the lead-in area () seamlessly merges into the functional contact surface () and that the lead-in area () ...

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Номер записи: 77
03-09-2020 дата публикации

SYSTEMS AND METHODS FOR FLUID DELIVERY MANIFOLDS

Номер: US20200276082A1
Автор: Koska Marc Andrew, Walker Jay S.
Принадлежит:

A fluid delivery manifold system assembled and configured to allow delivery of a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient. The delivery assembly generally includes a modular manifold design consisting of separately constructed components cooperatively arranged and coupled to one another. The modular manifold construction allows for rapid manufacturing reconfigurations of one or more components with minimal costs to create new delivery manifold configurations that meet specific needs (i.e., different modes of delivery depending on agent to be delivered, such as subcutaneous, intramuscular, intradermal, intravenous injection, spray, or droplet delivery). 1. A fluid delivery manifold system for delivery of a fluid agent , the fluid delivery manifold system comprising:a blow-fill-seal (BFS) package comprising a plurality of individual BFS vials coupled together, each BFS vial containing a single dose of a fluid agent and each BFS vial comprising a neck having at least one mating feature disposed on an exterior surface thereof;a fluid delivery manifold comprising a plurality of fluid delivery hubs coupled together, each fluid delivery hub defining an interior volume having one or more mating features disposed on an interior surface therein, and each of the one or more mating features being coupled to a corresponding at least one mating feature of one of the BFS vial necks:a safety cap manifold comprising a plurality of safety caps coupled together, each safety cap defining a void in which one of the fluid delivery hubs is disposed;a plurality of fluid seal elements, each fluid seal element being retained between one of the safety caps and a respective fluid delivery hub; anda plurality of administration members, each administration member being coupled to one of the fluid seal elements.2. The fluid delivery manifold system of claim 1 , wherein each fluid delivery hub comprises a seal seat ...

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Номер записи: 78
26-10-2017 дата публикации

SYSTEM AND METHOD FOR PROVIDING AN INJECTION

Номер: US20170304525A1
Автор: Roedle Tilman
Принадлежит: VETTER PHARMA-FERTIGUNG GMBH & CO. KG

A system for preparing an injection includes a first container with a first cavity and a rigid outer wall and two ends, a movable stopper being provided on one side of the first cavity, which sealingly closes this cavity and is displaceable inside the first container and comprising a second container, which encloses a second cavity, one container comprising a first substance, and the other container comprising a second substance. The second container comprises an at least regionally elastic wall and in this way has a variable volume. The second container is designed such that a pressure can be built inside the second container by way of the at least regionally elastic wall. The second container is a tube. 118-. (canceled)19. A system for preparing an injection , the system comprisinga first container defining a first cavity for a first substance and having a rigid outer wall and two ends;a movable stopper provided on one side of the first cavity which sealingly closes the first cavity and is displaceable inside the first container; anda second container enclosing a second cavity for a second substance, the second container being a tube,wherein the first container and the second container are connected to one another such that the first and second cavities are in fluid connection with one another,wherein the second container includes an at least regionally elastic wall so as to have a variable volume, the at least regionally elastic wall operable to build a pressure in the second container.20. The system according to claim 19 , wherein one of the first and second substances is solid claim 19 , and the other of the first and second substances is liquid.21. The system according to claim 19 , wherein the first and second substances are liquid.22. The system according to claim 20 , wherein the first substance is a lyophilizate claim 20 , and the second substance is a solvent for the lyophilizate.23. The system according to claim 22 , wherein a lyophilizate is present in ...

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Номер записи: 79
17-09-2020 дата публикации

PHARMACEUTICAL CONTAINER AND LIQUID COMPOSITION

Номер: US20200289758A1
Автор: Horsch Elmar, Woywod Tanja
Принадлежит: SCHOTT AG

A pharmaceutical container for drug delivery includes a barrel configured to slidably receive a stopper. The stopper has a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition. The stopper has a circumferential surface partially contacting an inner surface of the barrel. A surface roughness of the inner surface of the barrel declines from the stopper's start position to its end position by at least 3% of at least one of Ra roughness or Rms roughness.

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Номер записи: 80
17-09-2020 дата публикации

PHARMACEUTICAL CONTAINER AND LIQUID COMPOSITION

Номер: US20200289759A1
Автор: Horsch Elmar
Принадлежит: SCHOTT Schweiz AG

A pharmaceutical container for drug delivery includes a barrel configured to slidably receive a stopper. The container exhibits a ratio of a break loose force (BLF) relative to a glide force (GF) of BLF/GF≤2 during a break loose and glide force test and a total glide force variation TGFV=GF−GFmeasured when the stopper is moved from a start position to its end position is TGFV<2 N.

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Номер записи: 81
25-10-2018 дата публикации

STORAGE AND DISPENSER DEVICE

Номер: US20180304061A1
Автор: Sautereau Christophe
Принадлежит: MERIAL INC.

A storage and manual dispenser apparatus for dispensing a pharmaceutical liquid under atmospheric pressure. This apparatus retains the liquid in a controlled and stable environment during storage. 1. A device for storing and dispensing a pharmaceutical liquid comprising:A) a substantially rigid elongated container defining an interior space and configured to hold the liquid therein, having a proximal end and a distal end with respective openings and a passage extending between the openings, the proximal opening being closed by a container seal and the distal end of the container tapering into an applicator tip which is integral therewith;B) an air valve sealingly coupled to the proximal end of the container, wherein the air valve comprises a penetrating tip which can puncture the container seal to enabling air communication to be formed through the valve between the interior of the container and the external environment, the valve being positionable in a stored position in which the seal is not punctured by the penetrating tip, and in a dispensed position in which the seal is punctured by the penetrating tip and the air communication is formed, and in a sealed position in which the seal is punctured by the penetrating tip and an airtight seal is formed to prohibit air communication being formed; and wherein dispensing the liquid through the applicator tip is controlled by the air communication.2. A device according to claim 1 , wherein the valve further comprises a spring which biases the penetrating tip away from the container seal.3. A device according to claim 1 , wherein the air valve further comprises a cap having a top and side wall whose interior is of generally cylindrical configuration and of diameter slightly greater than the outside diameter of the proximal end of the container claim 1 , said cap being sealingly coupled to the proximal end of the container and further comprises an air inlet which opens and permits air communication to be formed when the ...

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Номер записи: 82
07-12-2017 дата публикации

TOOTHPICK FOR PERIODONTAL CARE

Номер: US20170348078A1
Автор: LEE Dae Kyung
Принадлежит:

Disclosed is a toothpick for periodontal care for applying a drug in an oral cavity. The toothpick for periodontal care according to the present invention includes: a drug container which accommodates a drug for periodontal care; and a toothpick part which is provided at one end portion of the drug container and has a nozzle hole that is formed in a longitudinal direction and communicates with an internal space of the drug container so as to apply the drug for periodontal care between a user's teeth. 1. A toothpick for periodontal care , comprising:a drug container which accommodates a drug for periodontal care; anda toothpick part which is provided at one end portion of the drug container and has a nozzle hole that is formed in a longitudinal direction and communicates with an internal space of the drug container so as to apply the drug for periodontal care between a user's teeth.2. The toothpick of claim 1 , wherein the drug container includes:a container extrusion part which is deformed by being pushed by the user and extrudes the drug for periodontal care through the toothpick part; anda container support part which is connected to the container extrusion part, is made of a material harder than a material of the container extrusion part, and imparts rigidity to the drug container.3. The toothpick of claim 2 , wherein the container extrusion part is extended along the container support part from one end portion to the other end portion of the container support part.4. The toothpick of claim 2 , wherein based on a cross section of the drug container claim 2 , the container extrusion part defines one side of the drug container claim 2 , and the container support part defines the other side of the drug container.5. The toothpick of claim 4 , wherein the container support part is shaped to be fully filled with a material and does not accommodate the drug for periodontal care.6. The toothpick of claim 2 , wherein the container extrusion part is made of a plastically ...

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Номер записи: 83
14-12-2017 дата публикации

METHOD AND SYSTEM FOR MAKING CUSTOMIZED FORMULATIONS HAVING A THIXOTROPIC HYDROCOLLOID FOR INDIVIDUALS

Номер: US20170357898A1
Автор: Hudson Edison Thurman, Noel Lloyd Staton
Принадлежит:

The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested. 1 receive health-related information from an individual;', 'receive taste-related preference data from a individual;', 'based on the health-related information, determine a suggested formulation for a supplement for the individual;', 'based on the taste-related preference data, determine a suggested filler medium;', 'receive individual alterations to each of the suggested formulation and suggested filler medium., 'a computing device configured to. A system comprising: This application is a continuation application of U.S. patent application Ser. No. 15/620,915 filed on Jun. 13, 2017, which is a continuation of U.S. patent application Ser. No. 14/207,364 filed on Mar. 12, 2014, which claims priority to U.S. Provisional Patent Application No. 61/777,181, filed on Mar. 12, 2013, the contents of all of which are hereby incorporated by reference herein.This disclosure includes a method and system for assembling a subset of multiple compounds into a single, edible composition. This disclosure includes a method and system for assembling multiple compounds into a single, edible composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group.There is a need for customized formulations of dietary supplements and therapeutics based on the genetic, physical, physiological, and medical needs of an individual. Conventionally, typical formulations of supplements and therapeutics are prepared ...

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Номер записи: 84
14-12-2017 дата публикации

APPARATUS AND MACHINE FOR MAKING CUSTOMIZED FORMULATIONS HAVING A THIXOTROPIC HYDROCOLLOID FOR INDIVIDUALS

Номер: US20170357899A1
Автор: Hudson Edison Thurman, Noel Lloyd Staton
Принадлежит:

The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested. 1 receive health-related information from an individual;', 'receive taste-related preference data from a individual;', 'based on the health-related information, determine a suggested formulation for a supplement for the individual;', 'based on the taste-related preference data, determine a suggested filler medium;', 'receive individual alterations to each of the suggested formulation and suggested filler medium., 'a computing device configured to. A system comprising: This application is a continuation application of U.S. patent application Ser. No. 15/620,915 filed on Jun. 13, 2017, which is a continuation of U.S. patent application Ser. No. 14/207,364 filed on Mar. 12, 2014, which claims priority to U.S. Provisional Patent Application No. 61/777,181, filed on Mar. 12, 2013, the contents of all of which are hereby incorporated by reference herein.This disclosure includes a method and system for assembling a subset of multiple compounds into a single, edible composition. This disclosure includes a method and system for assembling multiple compounds into a single, edible composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group.There is a need for customized formulations of dietary supplements and therapeutics based on the genetic, physical, physiological, and medical needs of an individual. Conventionally, typical formulations of supplements and therapeutics are prepared ...

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Номер записи: 85
14-12-2017 дата публикации

APPARATUS AND MACHINE FOR MAKING CUSTOMIZED FORMULATIONS BASED ON USER INPUT

Номер: US20170357900A1
Автор: Hudson Edison Thurman, Noel Lloyd Staton
Принадлежит:

The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested. 1 receive health-related information from an individual;', 'receive taste-related preference data from a individual;', 'based on the health-related information, determine a suggested formulation for a supplement for the individual;', 'based on the taste-related preference data, determine a suggested filler medium;', 'receive individual alterations to each of the suggested formulation and suggested filler medium., 'a computing device configured to. A system comprising: This application is a continuation application of U.S. patent application Ser. No. 15/620,915 filed on Jun. 13, 2017, which is a continuation of U.S. patent application Ser. No. 14/207,364 filed on Mar. 12, 2014, which claims priority to U.S. Provisional Patent Application No. 61/777,181, filed on Mar. 12, 2013, the contents of all of which are hereby incorporated by reference herein.This disclosure includes a method and system for assembling a subset of multiple compounds into a single, edible composition. This disclosure includes a method and system for assembling multiple compounds into a single, edible composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group.There is a need for customized formulations of dietary supplements and therapeutics based on the genetic, physical, physiological, and medical needs of an individual. Conventionally, typical formulations of supplements and therapeutics are prepared ...

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Номер записи: 86
14-11-2019 дата публикации

HOLLOW BODY HAVING A WALL WITH A LAYER OF GLASS AND AT LEAST ONE ELEVATED REGION

Номер: US20190343720A1
Автор: Mangold Stephanie, Rudigier-Voigt Eveline, Sweeck Tamara
Принадлежит: SCHOTT AG

A hollow body includes a wall which at least partially surrounds an interior volume of the hollow body. The wall comprises a layer of glass comprising a first glass composition, comprises a base surface, and has a wall surface. The wall surface comprises at least one surface region, in which the base surface is at least partially superimposed by at least one elevated region, and at least one contact region, which extends along a contact range of a height of the hollow body. The at least one elevated region comprises a further glass composition. An exterior diameter of the hollow body has a maximum throughout the contact range. The at least one surface region is at least partially positioned in the at least one contact region. 1. A hollow body , comprising:a wall which at least partially surrounds an interior volume of the hollow body, the wall comprising a layer of glass comprising a first glass composition, having a wall surface, and comprising a base surface, the wall surface comprising at least one surface region, in which the base surface is at least partially superimposed by at least one elevated region, and at least one contact region, which extends along a contact range of a height of the hollow body, the at least one elevated region comprising a further glass composition, an exterior diameter of the hollow body having a maximum throughout the contact range, the at least one surface region being at least partially positioned in the at least one contact region.2. The hollow body according to claim 1 , wherein the at least one elevated region is transparent.3. The hollow body according to claim 1 , wherein the at least one surface region extends along at least 25% of a circumference of the hollow body.4. The hollow body according claim 1 , wherein the hollow body is a packaging container for at least one of a medical packaging good or a pharmaceutical packaging good.5. The hollow body according to claim 1 , wherein the wall surface comprises a first surface ...

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Номер записи: 87
12-11-2020 дата публикации

Device for Deterring Abuse of Drugs

Номер: US20200353179A1
Автор: Iorio Matthew
Принадлежит:

The present disclosure relates to devices for deterring drug abuse and methods thereof. More particularly, the disclosure relates to devices for deterring drug abuse by using physical deterrents and/or deterrent substances, including a locking mechanism that dispenses a deterrent substance when the drug is improperly accessed. The present disclosure also relates to methods of accessing a drug from such devices. 2. The device as defined by claim 1 , wherein the drug is accessed by moving the physical deterrent relative to the housing claim 1 , and the physical deterrent is oriented relative to the housing in such a way as to prevent and/or significantly hinder access to the access port when in the locked mode claim 1 , and the physical deterrent is oriented relative to the housing in such a way to allow access to the access port when in the unlocked mode.3. The device as defined by claim 1 , further comprising a rod that connects the housing and the physical deterrent claim 1 ,the rod being normally movable in the unlocked mode, to allow for the physical deterrent to transition from the secure position to the unsecure position,the rod further being normally immobile in the locked mode, to prevent the physical deterrent from transition from the secure position to the unsecure position,the movement of the rod changing the orientation of the housing relative to the physical deterrent.4. The device as defined by claim 1 , wherein the housing is rotatable relative to the physical deterrent in the unlocked mode claim 1 , and the housing is not rotatable relative to the physical deterrent in the locked mode.5. The device as defined by claim 1 , wherein the housing is an IV fluid bag claim 1 , a vial claim 1 , a syringe claim 1 , a canister claim 1 , or a bottle.6. The device as defined by claim 1 , wherein the deterrent substance is a drug antagonist claim 1 , a chemical irritant claim 1 , a gelling agent claim 1 , a colorant claim 1 , an emetic claim 1 , and/or an ...

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Номер записи: 88
19-11-2020 дата публикации

FILING SYSTEM AND METHODS FOR ASEPTIC CARTRIDGE AND DISPENSER ARRANGEMENT

Номер: US20200360231A1
Автор: Genosar Amir
Принадлежит:

A package for use with a beneficial agent delivery device. The package includes at least one filling chamber having a sealed penetrable access region, at least one compartment configured to hold a content, wherein the content includes at least one of a beneficial agent or a constituent of a beneficial agent, and at least one channel connecting the at least one filling chamber in fluid communication with the at least one compartment. At least a portion of the package is resealable to contain the content. 120.-. (canceled)21. A filling system , comprising:at least one body for receiving a sealed package, the package comprising at least one filling chamber, at least one channel, and at least one compartment;at least one piercing element operable to pierce the sealed package at an access region; andat least one sealing member operable to seal the package.221. The filling system of claim , wherein the at least one body comprises a cavity for holding a package , comprising a region for at least one of at least one filling chamber , at least one channel , and at least one compartment.231. The filling system of claim , wherein the at least one piercing element is configured to at least one of fill content into the package and remove content from the package.241. The filling system of claim , wherein the piercing element pierces the package to access the at least one filling chamber.252. The filling system of claim , wherein the cavity and the at least one compartment are congruent.262. The filling system of claim , having a controllable pressure therein configured to retain a wall of the package congruently in the cavity.272. The filling system of claim , wherein a vacuum force maintains at least a portion of a wall of the compartment congruent with the cavity.281. The filling system of claim , wherein a vacuum force enhances a fluid-tight seal between the filling system and the access region.291. The filling system of claim , wherein the at least one sealing member is ...

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Номер записи: 89
10-12-2020 дата публикации

A DEVICE FOR DISCHARGING A POURABLE SUBSTANCE

Номер: US20200385181A1
Автор: Hiemer Andreas, Seitz Sebastian, Sògaro Alberto C.
Принадлежит:

A device for discharging a flowable substance, in particular for applying a medical substance, a pharmaceutical substance, a food supplement or a cosmetics, includes_an activation mechanism and a body which has a discharge opening at a first end and forms a containing space in which a frangible capsule is disposed. The capsule has two ends each having a first and a second tip and at least one of the two tips can be snapped off by actuating the activation mechanism so that the flowable substance is discharged. 1. A device for discharging a flowable substance , in particular for applying a medical substance , a pharmaceutical substance , a food supplement or a cosmetics , the device comprising an activation mechanism and a body which has a discharge opening at a first end and forms a containing space in which a frangible capsule is disposed , characterized in that the capsule has two ends each having a first and a second tip and in that at least one of the two tips can be snapped off by actuating the activation mechanism so that the flowable substance is discharged.2. The device according to claim 1 , wherein the capsule is made of glass.3. The device according to claim 1 , wherein the two ends of the capsule each have a predetermined breaking point for removing the respective tip.4. The device according to claim 1 , wherein the capsule is positioned in the containing space by the activation mechanism and/or the body.5. The device according to claim 1 , wherein the body has an end section at the first end claim 1 , the end section being where the first tip of the capsule is disposed.6. The device according claim 5 , wherein the end section is made of an elastic claim 5 , frangible or compressible material.7. The device according to claim 5 , wherein the end section is a tipping lock or a Luer lock claim 5 , the end section has grip elements and/or the end section forms a spoon at an end facing away from the body.8. The device according to claim 1 , wherein an ...

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Номер записи: 90
08-11-2007 дата публикации

Verschlusssystem für Behältnisse

Номер: DE102006040888B3
Автор: Hans-Rainer Dr. Hoffmann, Rudolf Prof. Dr. Matusch
Принадлежит: LTS Lohmann Therapie Systeme AG

Die Erfindung betrifft ein Verschlusssystem für Behältnisse zur Aufbewahrung oder Verabreichung von flüssigen, pastösen oder pulverförmigen Stoffen, das aus einer - mit einem Durchgangsloch ausgestatteten Kappe und einem Verschlusselement besteht, wobei die Kappe das Verschlusselement auf dem Behältnis im Bereich der zu verschließenden Öffnung mittels eines am Behältnis vorhandenen Hintergriffs kraft- und/oder formschlüssig hält. Dazu weist die die Behältnisöffnung umgebende Stirnfläche, auf der das Verschlusselement auf, eine Vertiefung auf. Das Verschlusselement ist eine viren-, bakterien- und sporendichte Folie, die auf der Stirnfläche und zumindest bereichsweise über der Vertiefung liegt. Beim Aufsetzen der Kappe ist zwischen dem Verschlusselement und der Vertiefung ein Elastomer- oder Klebstoffring angeordnet, der die Vertiefung ausfüllt. Mit der vorliegenden Erfindung wird ein Verschlusssystem für Behältnisse entwickelt, das ein viren-, bakterien- und sporendichtes und dauerhaft sicheres Verschließen des Behältnisses ermöglicht.

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Номер записи: 91
30-05-2002 дата публикации

Pre-filled disposable pipettes

Номер: WO2002042175A1
Автор: Frank Zhishi Xia, Jack Yongfeng Zhang, Mary Ziping Luo
Принадлежит: Amphastar Pharmaceuticals Incorporation

A pre-filled disposable pipette body (40) for pharmaceutical and cosmetic products. The body consists of a hollow, rigid bulb section (44) forming a reservoir for storage and dispersion of the liquid (48) pharmaceutical or cosmetic product which is pre-filled within the body (40). The body (40) further includes a hollow tubular section (46) that is smaller in diameter and contiguous with the bulb section (44). The preferred embodiment has a hollow, frangible upper tube (42), with a distal end that is sealed for introducing air into the body (40) when the seal is broken, thus releasing the liquid (48) from the tubular section (46). The second embodiment has a resilient bulb section (44) and omits the upper tube. A tapered section (90) is added to the tubular section (46), with a hollow tip (86) on the end. A seal is in contact with the hollow tubular section, or tip, for retaining the liquid within the body and storage, consisting of either a liquid seal (58) or a resilient cap (50).

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Номер записи: 92
05-02-2004 дата публикации

Sterile containers

Номер: US20040022674A1
Автор: Josef Schneider, Jurgen Thurk
Принадлежит: Schott Glaswerke AG

A sterile packaging is provided. The sterile packaging includes one or several containers packaged in a gas-permeable and microbiologically impervious manner for sterilizing by means of plasma.

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Номер записи: 93
10-11-2022 дата публикации

Medical Device, Medical Device Assembly Including the Same, and Method of Reconstitution of a Pharmaceutical Composition

Номер: US20220354746A1
Автор: Ambicai Venkatachalapathy, Rajesh POOLA
Принадлежит: Becton Dickinson and Co

A medical device is configured to be connectable with a vial. The medical device includes a tubular body and an adapter. The tubular body defines a container for containing a composition, and has a spike located at a distal end thereof. The spike has at least one through hole in fluid communication with the container. The adapter is formed with or coupled to the body, and is located at or about the spike.

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Номер записи: 94
22-12-2022 дата публикации

Resin Container and Resin Container Connected Body

Номер: US20220401300A1
Автор: Ikeda Naohiro, KAWAI Keita
Принадлежит: ROHTO PHARMACEUTICAL CO., LTD.

The present invention is a resin container in which an inner wall surface of a container body includes a cyclic olefin copolymer, and a diameter upstream of an outlet of the container body ranges from 0.5 mm to 8.0 mm. 1: A resin container , comprising:a container body made of resin, configured to store liquid content, and including an outlet,wherein the container body includes a body portion configured to store the liquid content,the outlet of the container body has a smaller diameter than the body portion,an inner wall surface of the container body that comes into contact with the liquid content includes a cyclic olefin copolymer, andat least a portion of a flow path of the liquid content upstream of the outlet has a diameter ranging from 0.5 mm to 8.0 mm.2: The resin container according to claim 1 ,wherein a proportion of the cyclic olefin copolymer with respect to a resin forming the inner wall surface ranges from 55 mass % to 98 mass %.3: The resin container according to claim 1 ,wherein the inner wall surface further includes a linear low-density polyethylene resin.4: The resin container according to claim 1 ,{'sub': '0', 'sup': 2', '2, 'wherein the body portion has an inner lateral cross-sectional area (S) ranging from 20 mmto 300 mm.'}5: The resin container according to claim 4 ,{'sub': 0', '1', '0', '1, 'wherein a ratio (S/S) between the inner lateral cross-sectional area (S) of the body portion and a lateral cross-sectional area (S) of the flow path ranges from 1.5 to 60.'}6: The resin container according to claim 1 ,wherein the container body has a volume ranging from 0.1 mL to 10 mL.7: The resin container according to claim 6 ,wherein the liquid content is an external use product.8: A resin container connected body claim 6 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a connected body having a configuration in which a plurality of the container bodies of the resin containers according to are connected together,'}wherein, in the ...

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Номер записи: 95
26-08-2010 дата публикации

Implantable drug delivery devices

Номер: WO2010096449A2
Автор: Michael R. Violante, Youti Kuo
Принадлежит: PharmaNova, Inc.

The invention relates generally to implantable drug delivery devices. Devices having a single drug chamber configuration, a divided drug chamber configuration and a compact dual-drug configuration are described. The devices have features to prevent clogging of the dispensing catheter and the creation of a local vacuum caused by the dispensing of the drug fluid. Also provided are features of a failsafe refilling process, automatic refill notification, and performance verification process. The divided drug chamber configuration enables frequent or continuous minute doses. A dual-drug chamber configuration uses self-locking refill containers to prevent mismatching between refill containers and drug chambers.

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Номер записи: 96
10-04-2019 дата публикации

Coded collapsible drug reservoir

Номер: EP3421028A3
Автор: Richard James Vincent Avery
Принадлежит: Sanofi Aventis Deutschland GmbH

A coded collapsible drug reservoir (200) and a drug delivery system (100) including a coded collapsible drug reservoir (200). The drug reservoir (200) includes a collapsible housing (202) and a port (204) in communication with the collapsible housing (202). The drug reservoir (200) further includes a coding feature (206) disposed on the drug reservoir (200), and the coding feature (206) identifies the drug reservoir (200).

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Номер записи: 97
25-01-2018 дата публикации

Device for storing and metering a sterile fluid

Номер: DE102016108873B4
Автор: Markus Kämereit, Nicholas Smartt
Принадлежит: GERRESHEIMER REGENSBURG GMBH

Die Erfindung betrifft eine Vorrichtung zum Aufbewahren und zum mehrmaligen dosierten Abgeben eines sterilen Fluids, insbesondere Augentropfen, umfassend einen Vorratsbehälter zum Aufbewahren des sterilen Fluids und eine Abgabeeinrichtung, wobei eine Teilmenge des sterilen Fluids innerhalb eines Abgabezyklus abgebbar ist, welcher zumindest einen Ruhezustand und einen Abgabezustand umfasst. Die Vorrichtung ist dadurch gekennzeichnet, dass im Ruhezustand eine erste fluidische Verbindung zwischen dem Vorratsbehälter und einer Dosierungseinrichtung besteht und in der Dosierungseinrichtung eine Fluidtransfereinrichtung angeordnet ist, wobei durch eine erste Verlagerung der Dosierungseinrichtung relativ zu der Fluidtransfereinrichtung die erste fluidische Verbindung mittels der Fluidtransfereinrichtung verschließbar ist und wobei durch eine weitere Verlagerung der Dosierungseinrichtung relativ zu der Fluidtransfereinrichtung eine zweite fluidische Verbindung zwischen der Dosierungseinrichtung und der Abgabeeinrichtung mittels der Fluidtransfereinrichtung öffenbar ist. The invention relates to a device for storing and repeatedly dosing a sterile fluid, in particular eye drops, comprising a reservoir for storing the sterile fluid and a dispenser, wherein a subset of the sterile fluid within a dispensing cycle can be issued, which at least one idle state and a dispensing state includes. The device is characterized in that in the idle state there is a first fluidic connection between the reservoir and a metering device and a fluid transfer device is arranged in the metering device, wherein the first fluidic connection by means of the fluid transfer device can be closed by a first displacement of the metering device relative to the fluid transfer device wherein, by a further displacement of the metering device relative to the fluid transfer device, a second fluidic connection between the metering device and the delivery device can be opened by means of the fluid transfer ...

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Номер записи: 98
10-01-2013 дата публикации

Agent dispenser and sublingual device

Номер: RU2471474C2
Автор: Филипп ПЕРОВИЧ
Принадлежит: Филипп ПЕРОВИЧ

FIELD: medicine. SUBSTANCE: invention refers to medicine and pharmaceutical industry, and concerns a cavity (10) for preparing and introducing an alcohol solution containing at least lipophilic agents 0.1 to 5 ml. The cavity (10) contains a head (12) taking a first storage position P1 and a second use position P2 wherein said head (12) in found in a closer position with respect to the cavity (10). The head (12) comprises a tip (14) with a tip length specified so that a free end of an outlet passage (16) provides sublingual and/or paragingival drug penetration. The cavity may comprise at least two compartments (52) separated by a hermetic partition (54). The cavity comprises a cap (40) and cap (40) and/or partition (54) puncture (24) on the tip (14). The puncture (24) is provided in an immediate proximity from the compartments (52) so that mixing the substances in said compartments is performed in a certain order. EFFECT: provided sublingual and/or paragingival drug penetration. 10 cl, 8 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 471 474 (13) C2 (51) МПК A61J A61J A61J 7/00 1/00 1/14 (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2010106050/15, 18.07.2008 (24) Дата начала отсчета срока действия патента: 18.07.2008 (73) Патентообладатель(и): ПЕРОВИЧ Филипп (FR) R U Приоритет(ы): (30) Конвенционный приоритет: 20.07.2007 FR 0705290 (72) Автор(ы): ПЕРОВИЧ Филипп (FR) (43) Дата публикации заявки: 27.08.2011 Бюл. № 24 2 4 7 1 4 7 4 (45) Опубликовано: 10.01.2013 Бюл. № 1 (56) Список документов, цитированных в отчете о поиске: US 2004/0074925 А1, 22.04.2004. US 4898293, 06.02.1990. US 2005/0016875 A1, 27.01.2005. 2 4 7 1 4 7 4 R U (86) Заявка PCT: FR 2008/051368 (18.07.2008) C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 24.02.2010 (87) Публикация заявки РСТ: WO 2009/016309 (05.02.2009) Адрес для переписки: 103735, Москва, ул.Ильинка, 5/2, ООО "Союзпатент", пат.пов. ...

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Номер записи: 99
24-09-2009 дата публикации

Cuttable ampoule and forming method of cutting groove

Номер: KR100918432B1
Автор: 홍동희
Принадлежит: 홍동희

PURPOSE: An ampule bottle and a cut-off groove formation method are provided, which makes a cutting neck part easily cut by forming the cut-off groove along the outer circumference of the cutting neck part. CONSTITUTION: An ampule bottle includes a cutting neck part. The cutting neck part is formed to cave between the body part(1) and inlet part(2). A cut-off groove is formed in a ring shape along the outer circumference of the cutting neck part. In the cut-off groove, a scattering prevention membrane is formed. The scattering prevention membrane prevents particles of the glass from falling in the process that the cut-off groove is cut.

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Номер записи: 100