26-06-2014 дата публикации
Номер: US20140179701A1
Disclosed is a composition effective in reducing skin wrinkles. The composition comprises or uses a phosphodiesterase 5 (PDE5) inhibitor as an active ingredient. Further disclosed is a method for reducing skin wrinkles using the composition. 1. A method for reducing skin wrinkles comprising administering to a subject in need thereof a therapeutically effective amount of a phosphodiesterase 5 (PDE5) inhibitor , or a pharmaceutically acceptable salt , solvate or hydrate thereof , wherein the PDE5 inhibitor is at least one selected from the group consisting of 2-[2-ethoxy-5-(4-methyl-piperazine-1-sulphonyl)-phenyl]-5 ,7-dimethyl-3H-imidazo[5 ,1-f]-[1 ,2 ,4]triazin-4-one , 2-[2-ethoxy-5-(4-hydroxyethylpiperazine-1-sulphonyl)-phenyl]-5 ,7-dimethyl-3H-imidazo[5 ,1-f]-[1 ,2 ,4]triazin-4-one , 2-[2-ethoxy-5-(4-hydroxypiperidine-1-sulphonyl)-phenyl]-5 ,7-dimethyl-3H-imidazo[5 ,1-f]-[1 ,2 ,4]triazin-4-one , 2-[2-ethoxy-5-(4-hydroxymethylpiperidine-1-sulphonyl)-phenyl]-5 ,7-dimethyl-3H-imidazo[5 ,1-f][1 ,2 ,4]triazin-4-one , 2-[2-ethoxy-5-(3-hydroxypyrrolidine-1-sulphonyl)-phenyl]-5 ,7-dimethyl-3H-imidazo[5 ,1-f][1 ,2 ,4]triazin-4-one , 4-ethoxy-N-ethyl-N-(2-hydroxyethyl)-3-(5 ,7-dimethyl-4-oxo-3 ,4-dihydroimidazo[5 ,1-f][1 ,2 ,4]triazin-2-yl)benzenesulfonamide , N ,N-diethyl-4-ethoxy-3-(5 ,7-dimethyl-4-oxo-3 ,4-dihydroimidazo[5 ,1-f][1 ,2 ,4]triazin-2-yl)benzenesulfonamide , 2-[2-ethoxy-5-(4-(2-pyrimidinyl)-piperazine-1-sulphonyl)-phenyl]-5 ,7-dimethyl-3H-imidazo-[5 ,1-f][1 ,2 ,4]triazin-4-one , 2-[2-ethoxy-5-(morpholine-4-sulphonyl)-phenyl]-5 ,7-dimethyl-3H-imidazo-[5 ,1-f][1 ,2 ,4]triazin-4-one , 2-[2-ethoxy-5-(1 ,4-dioxa-6-azaspiro[4.4]nonane-6-sulphonyl)-phenyl]-5 ,7-dimethyl-3H-imidazo[5 ,1-f][1 ,2 ,4]triazin-4-one , N ,N-bis-(2-methoxyethyl)-4-ethoxy-3-(5 ,7-dimethyl-4-oxo-3 ,4-dihydro-imidazo[5 ,1-f][1 ,2 ,4]triazin-2-yl)-benzenesulfonamide , N-(3-isoxazolyl)-4-ethoxy-3-(5 ,7-dimethyl-4-oxo-3 ,4-dihydro-imidazo[5 ,1-f][1 ,2 ,4]triazin-2-yl)-benzenesulfonamide , 2-[2- ...
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