05-03-2020 дата публикации
Номер: US20200069835A1
The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O— groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers. 1. A method of preparing a foam suitable for packing antrums or other cavities of the human or animal body , said method comprising the steps of: [{'br': None, 'A-R-A′\u2003\u2003(III),'}, {'br': None, 'O═C═N—R′—N═C═O \u2003\u2003(IV),'}, 'with one or more diisocyanates of a formula (IV), [{'br': None, 'B—R″—B′\u2003\u2003(V),'}, 'wherein A, A′, B and B′ are independently selected from hydroxyl, carboxyl or amine,', 'wherein R is selected from one or more aliphatic polyesters, polyetheresters, polyethers, polyanhydrides and/or polycarbonates, and at least one R comprises an amorphous segment and a crystalline segment, wherein the amorphous segment comprises a hydrophilic segment comprising polyethyleneglycol, polypropyleneglycol or polybutyleneglycol, and', {'sub': 2', '8', '1', '10', '1', '10', '2', '8, 'wherein R′ and R″ are independently C-Calkylene, optionally substituted with C-Calkyl or C-Calkyl groups substituted with protected S, N, P or O moieties and/or comprising S, N, P or O in the C-Calkylene;'}], 'and one or more chain extenders of a formula (V)], 'producing a phase-separated polymer in a solvent by reacting one or more pre-polymers according to a formula (III)cooling the phase-separated polymer in the solvent to crystallize the polymer and crystallize the ...
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