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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 15535. Отображено 100.
10-08-2013 дата публикации

Впрыскиватель для лекарств

Номер: RU0000130852U1
Автор: Сун Хюцк ЛЕЕ
Принадлежит: ДАЕВООНГ ФАРМАЦЕУТИКАЛ КО., ЛТД.

1. Впрыскиватель для лекарств, содержащий:вытеснительный стержень 11, который перемещается относительно защитного колпачка 10 для лекарства по осевой линии, проходящей в одном направлении от защитного колпачка 10 для лекарства, и оказывает давление на жидкое лекарственное вещество, содержащееся в защитном колпачке 10 для лекарства, чтобы вытеснить его из защитного колпачка для лекарства, и который имеет множество выступов 11, спирально расположенных на его наружной поверхности;поворотный элемент 17, который содержит направляющую деталь для направления перемещения выступов 111 и с возможностью поворота стационарно соединен с внутренней поверхностью главного корпуса 12 с целью перемещения вытеснительного стержня 11 и оказания давления на жидкое лекарственное вещество, при этом направляющая деталь выполнена на внутренней поверхности поворотного элемента;средство поворота, которое расположено между поворотным элементом 17 и главным корпусом 12 и служит для поворота поворотного элемента 17; ипрепятствующий повороту элемент 13, который установлен на главном корпусе 12 с возможностью вхождения в контакт с наружной поверхностью поворотного элемента 17 и выхода из контакта с наружной поверхностью поворотного элемента 17 с целью избирательного поворота поворотного элемента 17.2. Впрыскиватель для лекарств по п.1, дополнительно содержащий пружину 14, которая упруго давит на препятствующий повороту элемент 13 в направлении главного корпуса 12, чтобы препятствующий повороту элемент 13 выходил из контакта с поворотным элементом 17 за счет силы упругости пружины 14 и принудительно входил в контакт с поворотным элементом 17 за счет с РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 130 852 (13) U1 (51) МПК A61M A61M A61M 5/31 (2006.01) 5/315 (2006.01) 5/20 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ТИТУЛЬНЫЙ ЛИСТ ОПИСАНИЯ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21)(22) Заявка: 2012113898/14, 07.10.2010 (24) Дата начала отсчета срока действия патента: 07.10.2010 (73) Патентообладатель( ...

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Номер записи: 1
07-08-2018 дата публикации

Автоматический инъектор с защитой иглы

Номер: RU0000182223U1
Автор: Александр Сергеевич Мишкин, Антонина Александровна Сандетская, Сергей Викторович Львов
Принадлежит: Федеральное государственное унитарное предприятие "Московский эндокринный завод"

Полезная модель относится к медицинской технике, медицине и ветеринарии. Более конкретно полезная модель обеспечивает устройство для последовательного автоматического введения иглы и жидкого лекарственного средства в мышечную ткань и может быть использована при оказании скорой медицинской помощи населению и экстренной помощи людям и животным при чрезвычайных ситуациях, а также само- и взаимопомощи военнослужащим в военно-полевых условиях. Технический результат заключается в предотвращении возможности случайного постинъекционного ранения иглой. Указанный технический результат достигается тем, что в заявляемом автоматическом инъекторе применена система постинъекционной защиты иглы. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 182 223 U1 (51) МПК A61M 5/20 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК A61M 5/20 (2006.01) (21)(22) Заявка: 2018112482, 06.04.2018 (24) Дата начала отсчета срока действия патента: Дата регистрации: Приоритет(ы): (22) Дата подачи заявки: 06.04.2018 (56) Список документов, цитированных в отчете о поиске: RU 171991 U1, 23.06.2017. WO (45) Опубликовано: 07.08.2018 Бюл. № 22 (54) АВТОМАТИЧЕСКИЙ ИНЪЕКТОР С ЗАЩИТОЙ ИГЛЫ (57) Реферат: Полезная модель относится к медицинской ситуациях, а также само- и взаимопомощи технике, медицине и ветеринарии. Более военнослужащим в военно-полевых условиях. конкретно полезная модель обеспечивает Технический результат заключается в устройство для последовательного предотвращении возможности случайного автоматического введения иглы и жидкого постинъекционного ранения иглой. Указанный лекарственного средства в мышечную ткань и технический результат достигается тем, что в может быть использована при оказании скорой заявляемом автоматическом инъекторе медицинской помощи населению и экстренной применена система постинъекционной защиты помощи людям и животным при чрезвычайных иглы. R U 1 8 2 2 2 3 2010035060 A1, 01.04.2010. WO 2008029280 A2, 13.03.2008. US ...

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Номер записи: 2
12-01-2012 дата публикации

Drug Delivery Device

Номер: US20120010594A1
Автор: Alexander S. Cairns, Mark D. Holt, Mathias Romacker
Принадлежит: AMGEN INC

A drug delivery device includes a housing having an interior space, a needle having retracted and deployed states, an injector to move the needle between retracted and deployed states, and a reservoir disposed within the interior space, the reservoir configured to receive a volume of a drug and to be in fluid communication with the needle. The drug delivery device also includes a controller coupled to the injector and the reservoir, and configured to actuate the injector to move the needle from the retracted state to the deployed state only once, and to actuate the reservoir to deliver the volume of the drug to the patient as a single bolus after a preselected time period has elapsed, the controller disposed within the interior space and configured prior to being disposed within the interior space. The delivery device is wearable, disposable, and single-use.

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Номер записи: 3
02-02-2012 дата публикации

Device for the administration of injectable products with a controlled flow rate

Номер: US20120024987A1
Автор: Elisabeth Nägele Nacken
Принадлежит: INNOVA SALUD DESARROLLOS SANITARIOS SL

A device is for the administration of injectable products with controlled flow rate, with a container ( 23 ) in the form of both a syringe and an ampoule preloaded with the injectable product, an injection port ( 25 ) and a control valve ( 21 ) for controlling the outlet rate and pressure arranged between the injectable products and the injection port ( 25 ). A device for reducing the outlet flow rate depends on the pressure increase applied during the administration of the injectable product, the administration being moderated by closing the valve ( 21 ) when the pressure exceeds a predetermined limit. A device prevents the backflow of fluids during the administration of the injectable product. The valve ( 21 ) can be positioned both in the container ( 23 ) and at an injection end ( 27 ) including the injection port ( 25 ) which is coupled to the container ( 23 ).

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Номер записи: 4
02-02-2012 дата публикации

Medicament Delivery Device

Номер: US20120029443A1
Автор: Anders Holmqvist
Принадлежит: SHL GROUP AB

The present invention relates to a medical delivery device comprising a tubular distal housing; a tubular proximal housing; a medicament container arranged inside said tubular proximal housing; a threaded hollow plunger rod; a spring force means pre-tensioned arranged within said plunger rod; activation means arranged to be movable between a non-medicament delivery state and a medicament delivery state; dose setting means being threadedly arranged to said threaded hollow plunger rod and arranged to be rotationally moved between a stop position and a set dose position, whereby upon activation of said activation means from the non-medicament delivery state to the medicament delivery state, said threaded hollow plunger rod is linearly displaced due to the force of the pre-tensioned spring means such that the dose setting means is also linearly displaced from the set dose position to the stop position.

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Номер записи: 5
29-03-2012 дата публикации

Syringe drive device

Номер: US20120078180A1
Автор: Akihiro Ohta, Akinobu Okuda, Osamu Mizuno, Soichiro Fujioka, Tohru Nakamura
Принадлежит: Panasonic Corp

A syringe drive device 1 includes a cylinder holding section 3 configured to detachably hold a cylinder 201, a piston manipulating section 4 detachably coupled with a piston, and a piston drive section 5 including racks 31 A and 31 B coupled with the piston manipulating section 4 and configured to move the piston manipulating section 4 so that a piston 202 is moved in a push-in direction or a pull-out direction. A cylinder 200 A having a given capacity (for example, 50 cc) is directly loaded in the syringe drive device 1 with no adapter therebetween. A syringe 200 C having a different capacity (for example, 20 cc) is loaded in the syringe drive device 1 by means of a cylinder adapter 81 and a piston adapter 82.

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Номер записи: 6
05-04-2012 дата публикации

Piston and a container with such a piston

Номер: US20120081991A1
Автор: Jan Svensson
Принадлежит: INTRADRUG MEDICAL SYSTEMS AB

The invention relates to a piston ( 4 ) with a sealing element ( 7, 7 a - b ) for slideably sealing a container ( 1 ) with an essentially cylindrical inner surface. The sealing element ( 7, 7 a - b ) comprises an inner portion ( 7 b ) aligned against the piston and an outer ring portion ( 7 a ) which extends in a ring shape around the circumference of the piston and is arranged to engage the inner surface of the container ( 1 ). The outer ring portion is arranged to flex inwards towards the centre axis of the piston ( 4 ) when the piston is displaced inside container ( 1 ) in a first direction and the outer ring portion is arranged to flex outwards towards the inner surface of the container ( 1 ) when the piston is displaced inside the container ( 1 ) in second direction being opposite the first direction. At least a first ring shaped groove extends in a ring shape on a first side of the sealing element ( 7, 7 a - b ), said groove being arranged between the inner portion ( 7 b ) and the outer ring portion ( 7 a ) of the sealing element.

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Номер записи: 7
24-05-2012 дата публикации

pre-filled syringe or autoinjector

Номер: US20120130318A1
Автор: Matthew Young
Принадлежит: Oval Medical Technologies Ltd

The invention provides a syringe for dispensing a drug ( 1 ), comprising: a rigid syringe body,—a first container ( 2 ), in contact with and enclosing the drug; and a second container ( 3 ), enclosing the first container, the second container being less gas permeable than the first container, wherein the second container partially or fully forms the rigid syringe body or is held within the rigid syringe body. The invention preserves the drug but allows the drug to be easily accessed without the need for a user to remove a gas barrier structure as a separate action in addition to the other actions needed to deliver the drug.

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Номер записи: 8
24-05-2012 дата публикации

Tissue Desensitization Instrument & Method

Номер: US20120130340A1
Автор: Eric J. Knutson
Принадлежит: Individual

An automatic fluid injector ( 10, 66 , or 76 ) having a coolant-absorbent pad ( 24 ) for pressing onto a tissue site for desensitization. When the injector ( 10, 66, 76 ) is pressed further toward the tissue site, the contained fluid is pressurized, and an enclosed needle ( 16 ) moves distally to penetrate a distal wall of injector ( 10, 66, 76 ). While needle ( 16 ) is being repositioned distally, the pressurized fluid is blocked from flowing into needle ( 16 ). The fluid blockage prevents the fluid from inadvertently warming the cold, desensitizing pad ( 24 ) and causing the patient to experience pain during needle ( 16 ) penetration. When needle ( 16 ) penetrates to a preset depth, and is sealed in the tissues, then the pressurized fluid is unblocked, and flows automatically through needle ( 16 ). In another embodiment, an instrument ( 46 ) having a coolant-absorbent felt ( 52 ) is able to unobstructably desensitize tissues prior to penetration with sharps.

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Номер записи: 9
07-06-2012 дата публикации

Medicament Container Holder Arrangement

Номер: US20120143143A1
Автор: Antonio Bendek, Lucio Giambattista
Принадлежит: SHL GROUP AB

The present invention relates to a medicament container holder arrangement comprising a medicament container holder 16 and a medicament container 18 wherein the medicament container holder 16 is provided with distally arranged support surfaces 25 for flanges 24 arranged on a distal part of the medicament container 18 to be placed in said medicament container holder 16, which medicament container 18 is arranged with a needle shield 20 to the proximal end thereof, wherein said needle shield 20 has a diameter generally equal or larger than the diameter of said medicament container 18, wherein said medicament container holder arrangement further comprises holders arranged on the container holder for holding said medicament container 18 around a proximal shoulder portion 22 thereof and a resilient support element 23 arranged between the flanges 24 and the support surfaces 25 whereby the holders and the resilient support element 23 absorb and spread forces between the medicament container and the container holder.

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Номер записи: 10
19-07-2012 дата публикации

Injection device

Номер: US20120184900A1
Автор: Jeremy Marshall, Steven Mark Guy Rolfe
Принадлежит: OWEN MUMFORD LTD

A pen injection device designed for use with dual or multi-chamber cartridges 14 , is provided with an extended length plunger 24 having a non-drive portion 24 ′ on its forward end and the usual screw-threaded drive portion 24 ″ on its rearward end. This arrangement allows the plunger to be pushed forwardly whilst the dosing drive mechanism is disengaged to effect a reconstitution movement of the rearward bung 18 ′ in the cartridge. Thereafter the threaded portion on the plunger 24 ′ engages the drive mechanism to allow metered dosing.

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Номер записи: 11
02-08-2012 дата публикации

Disposable injector comprising at least one draw hook and a sliding wedge-type gear for unlocking a locking element

Номер: US20120197186A1
Автор: Rudolf Matusch
Принадлежит: Individual

A disposable injector with a housing ( 10 ) in which are arranged at least one mechanical spring energy store ( 50 ), at least one cylinder-piston unit that can be filled at least temporarily with an active substance, at least one piston actuation plunger ( 60 ) and at least one triggering unit ( 80 ). The spring energy store comprises at least one pre-loaded spring element. The spring-loaded piston actuation plunger has at least one traction rod ( 61 ) which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface ( 37 ) of the housing. An actuatable triggering slide device ( 82 ) unlocks the disposable injector and releases the supporting portion to allow it to move away from the resting surface.

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Номер записи: 12
02-08-2012 дата публикации

Drug Delivery Device

Номер: US20120197195A1
Автор: Nils Basso, René RICHTER, Robert Witt, Thomas Nagel
Принадлежит: Sanofi Aventis Deutschland GmbH

A drug delivery device ( 1 ), comprising a flexible container ( 9 ) for holding a drug ( 18 ) and an electrically activatable deformable squeezing member ( 8 ). The flexible container ( 9 ) comprises a container outlet ( 17 ) for dispensing a dose of the drug ( 18 ) from the flexible container ( 9 ). The squeezing member ( 8 ) is activatable for dispensing the dose of the drug ( 18 ). When activated, the squeezing member ( 8 ) is arranged and configured to squeeze the flexible container ( 9 ), thereby expelling the dose of the drug ( 18 ) from the flexible container ( 9 ) through the container outlet ( 17 ).

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Номер записи: 13
02-08-2012 дата публикации

Related to automatic injection devices

Номер: US20120197209A1
Автор: Joseph F. Julian, Stephen Bicknell, William L. Rudzena
Принадлежит: Abbott Biotech Ltd Bermuda

An injection device comprises a syringe extendible against a spring bias from a retracted position in a housing to a projecting injecting position. A spring biased plunger has collapsible elbows which, when the plunger is released, initially engage the end of the syringe to drive it to the projecting position, whereupon arresting of the syringe movement causes the elbows to collapse inside the syringe to allow the plunger to engage and drive the bung.

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Номер записи: 14
09-08-2012 дата публикации

Injection device with pricking protection and/or overload protection for a product container

Номер: US20120203186A1
Автор: Patrick Vogt, Ursina Streit
Принадлежит: Individual

An injection device having a distal end, and including a needle located inside the injection device in an initial position, wherein the needle is moveable to a puncturing position in which the needle projects from the distal end, an open region located distally relative to the needle in the initial position of the needle and having a dimension, and a reduction piece moveable relative to the opening region whereby the dimension may be reduced.

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Номер записи: 15
16-08-2012 дата публикации

Medicament Delivery Device

Номер: US20120209192A1
Автор: Oscar Alexandersson
Принадлежит: SHL GROUP AB

A medicament delivery device includes a generally elongated tubular housing having opposite proximal and distal parts; a needle shield sleeve slidably and coaxially arranged inside the housing with a proximal part of the sleeve protruding a distance outside the proximal part of the housing; a syringe carrier mechanism having a syringe carrier slidably and coaxially arranged within the needle shield sleeve, a syringe having a stopper, a medicament, and a needle, the syringe being coaxially arranged within the syringe carrier; and a holding member connected to the syringe carrier; a first activator member and a second activator member; a drive mechanism adapted to accumulate a drive force for moving the syringe carrier mechanism in a first step and a second step. The second activator member is arranged with an information device for producing audible, visual, and/or tactile feedback to a user about a completed injection.

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Номер записи: 16
30-08-2012 дата публикации

Seal Structures For Wet/Dry Automatic Injectors

Номер: US20120220930A1
Автор: Robert L. Hill, Steven M. Griffiths
Принадлежит: Meridian Medical Technologies Inc

An automatic injection device including a housing, a chamber with a first compartment and a second compartment, and a seal structure between the compartments. The seal structure is initially in a sealing condition that seals the first compartment from the second compartment, where the seal includes a plug and an outer sealing member. The plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment. The automatic injection device also includes a needle assembly and an activation assembly. Activation of the activation assembly causes (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.

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Номер записи: 17
06-09-2012 дата публикации

Medicated module with bypass and needle guard

Номер: US20120226238A1
Автор: Daniel Thomas De Sausmarez Lintell, James Alexander Davies, John David Cross, Malcolm Stanley Boyd, Naceur Rekaya, Simon Lewis Bilton, Steven Wimpenny
Принадлежит: Sanofi Aventis Deutschland GmbH

A medicated module attachable to a drug delivery device comprises a connecting body configured for attachment to the drug delivery device. A first needle is fixed within the connecting body and a movable needle hub is operatively coupled to the connecting body. A needle guard is operatively coupled to the connecting body and a biasing member is positioned between the connecting body and needle guard. A second needle is fixed within the needle hub. A first cavity within the connecting body defines a reservoir containing at least one dose of a medicament. The reservoir configured for fluid communication with the first and the second needle. The reservoir comprises a bypass configured to allow medicament from the drug delivery device to bypass the reservoir and exit the second needle.

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Номер записи: 18
04-10-2012 дата публикации

Palm-controlled injectors

Номер: US20120253314A1
Автор: Ehud Arbit, Russ Weinzimmer, Saac Rubinstein, Ziv Harish
Принадлежит: Individual

A palm-controlled device is disclosed for injection of a substance into an organism. The device includes a palm-receiving surface for receiving a palm of a hand, the palm receiving surface being shaped so that the palm is substantially parallel to a surface of an injection site of the organism while operating the device. The palm receiving surface can also be shaped so that the palm is substantially perpendicular to a surface of the injection site. The device also includes an injector having at least one pre-filled syringe, the palm-receiving surface being cooperative with the injector such that when pressure is applied to the palm-receiving surface, the injector is actuated so as to inject contents of the at least one pre-filled syringe. Actuation of the injector is by gradual pressure; not sudden motion. Single or multiple doses of same or different medications can be included in a single injector.

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Номер записи: 19
18-10-2012 дата публикации

Resettable Drive Mechanism for a Medication Delivery Device and Medication Delivery Device

Номер: US20120265151A1
Автор: Philippe Nzike, Steffen RAAB, Ulrich Brüggemann, Uwe Boeser, Uwe Dasbach
Принадлежит: Sanofi Aventis Deutschland GmbH

A resettable drive mechanism for a medication delivery device is proposed, said mechanism comprising a housing ( 13, 17, 40 ) with a proximal end and a distal end, a drive member ( 20 ) rotatable with respect to the housing in a second direction for delivering a dose of a medication, a piston rod ( 12 ) adapted to be driven in a distal direction with respect to the housing by the drive member, when the drive member rotates in the second direction, a stop member ( 26 ) adapted to prevent rotation of the drive member in a first direction opposite to the second direction with respect to the housing, when the stop member engages the drive member, and a clutch member ( 58 ) movable with respect to the housing between a delivery position (D) and a reset position (R), wherein, when the clutch member is in the delivery position, the stop member and the drive member are engaged and the drive member is prevented from rotating in the first direction with respect to the housing, and when the clutch member is in the reset position, the drive member and the stop member are disengaged, the drive member is rotatable in the first direction with respect to the housing and the piston rod is movable in the proximal direction with respect to the housing. Furthermore, a medication delivery device is provided.

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Номер записи: 20
01-11-2012 дата публикации

Dispenser device

Номер: US20120273526A1
Автор: Tsai-Ming Lin
Принадлежит: Dermato Plastica Beauty Dpb Co Ltd

A dispenser device comprising a pistol housing, a needle direction control mechanism, a boost mechanism, a quantification control mechanism, and a combination of a housing, a needle direction control mechanism, a boost mechanism, and a syringe positioning mechanism or a holding ring embodies the present invention with features and advantages shown as follows, (1) Uniform injection of agents synchronously mixed by not less than two contents; (2) Mixed agents not exposed in air; (3) Uniform injection, high air tightness, injection direction controlled by easy turning, smooth and convenient operation, high powerful operation via shifts of a push rod driven by a pressed trigger, promoted yield rate, assembly easily constructed, reduced manufacture cost, and convenient maintenance.

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Номер записи: 21
08-11-2012 дата публикации

Resettable drive mechanism for a drug delivery device

Номер: US20120279329A1
Автор: Catherine Anne MacDonald, Christopher Jones, Garen Kouyoumjian, George Cave, Robert Veasey
Принадлежит: Sanofi Aventis Deutschland GmbH

The present disclosure relates to a resettable drive mechanism for use in a drug delivery device. The drug delivery device is having a distal direction and a proximal direction. The drive mechanism comprises a drive rack engaged with a drive gear, a piston rack engaged with a piston gear and coupling means for coupling the drive gear with the piston gear. In a first state of the drive mechanism, the drive gear and the piston gear are coupled and the piston rack moves in distal direction when the drive rack is moved in distal direction. In a second state of the drive mechanism, the drive gear and the piston gear are decoupled and the piston rack is moveable in proximal direction for resetting the drive mechanism.

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Номер записи: 22
08-11-2012 дата публикации

Drive mechanism for a drug delivery device

Номер: US20120283648A1
Автор: Catherine Anne MacDonald, Christopher Jones, Garen Kouyoumjian, Robert Veasey, Simon Lewis Bilton
Принадлежит: Sanofi Aventis Deutschland GmbH

A first output member is rotatable around an axis relatively to the body. A second output member is movable relatively to the body along the axis. The first output member and the second output member are rotationally coupled. A drive feature is provided to generate a rotation of the first output member. A part which is removable from and attachable to the body is provided so that the first output member is unidirectionally rotationally coupled with the drive feature when the part is attached to the body.

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Номер записи: 23
08-11-2012 дата публикации

Assembly and Piston Rod for a Drug Delivery Device

Номер: US20120283652A1
Автор: Catherine Anne MacDonald, Christopher Jones, Garen Kouyoumjian, Robert Veasey
Принадлежит: Sanofi Aventis Deutschland GmbH

A drive mechanism for a drug delivery device ( 1 ) comprises a housing ( 2 ), a drive member ( 5 ) and a piston rod assembly ( 32 ). The drive member ( 5 ) is configured to be axially displaced in a dose setting direction with respect to the housing ( 2 ) for setting a dose of a drug ( 24 ) and to be axially displaced in a dose delivery direction with respect to the housing ( 2 ) for delivering the set dose of the drug ( 24 ). The drive member ( 5 ) comprises a drive feature ( 15 ). The piston rod assembly ( 32 ) comprises a set of interaction surfaces ( 17 ) for mechanical interaction with the drive feature ( 15 ), with at least two interaction surfaces ( 17 ) being axially and angularly offset with respect to each other. When the drive member ( 5 ) is displaced in the dose delivery direction for delivering the set dose, the drive feature ( 15 ) mechanically interacts with one of the interaction surfaces ( 17 ) and the piston rod assembly ( 32 ) rotates with respect to the housing ( 2 ), thereby rotating and axially displacing another one of the interaction surfaces ( 17 ) from a non-interaction position into an interaction position in which the drive feature ( 15 ) may interact with the other one of the interaction surfaces ( 17 ) when the drive mechanism is actuated once more for setting and delivering a further dose. Also, a piston rod ( 3 ) is proposed.

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Номер записи: 24
08-11-2012 дата публикации

Resettable drug delivery device

Номер: US20120283658A1
Автор: Andrew Mark Lindsay, Catherine Anne MacDonald, Christopher Jones, David Plumptre, Garen Kouyoumjian, Robert Veasey
Принадлежит: Sanofi Aventis Deutschland GmbH

A drive member for driving a piston rod in a drug delivery device is provided. The drive member is configured to be driven in a rotational movement by an actuating member. The drive member comprises a track for transmitting a driving load from the actuating member to the drive member. The track comprises both sections running in a distal and sections running in a proximal direction of the drive member. Moreover, a drug delivery device comprising such a drive member is provided.

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Номер записи: 25
29-11-2012 дата публикации

Pneumatic injector

Номер: US20120302992A1
Автор: Donald John Wanek, William Woodrow Brooks, Jr.
Принадлежит: Rochester Area Consulting Engineers (RACE)

This document discloses, among other things, an air-powered auto-injector device for subcutaneous delivery of a rescue drug. The device is configured for self-administered treatment of anaphylactic shock. Air is compressed by relative movement of a piston and a cylinder and released to subcutaneously drive an hypodermic needle.

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Номер записи: 26
06-12-2012 дата публикации

Medicament Delivery Device

Номер: US20120310156A1
Автор: Gunnar Elmén, Sebastian Karlsson
Принадлежит: SHL GROUP AB

Injection device for manual penetration and injection comprising a distal housing part ( 10 ); a proximal housing part ( 12 ) with a multi-chamber container ( 20 ); a plunger rod ( 40 ); a push button ( 70 ); an activation member ( 30 ); a drive force means( 100 ) and a locking member ( 50 ), wherein the device further comprises a guide rod ( 60 ) arranged to generate an audible and tactile indication of the start of an injection.

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Номер записи: 27
31-01-2013 дата публикации

Cartridge Holder Assembly for a Drug Delivery Device

Номер: US20130030378A1
Автор: Axel Teucher, Günther Sendatzki, Michael Jugl
Принадлежит: Sanofi Aventis Deutschland GmbH

The present invention relates to a cartridge holder assembly for a drug delivery device as well as to such drug delivery device and to a corresponding method of assembly, wherein the cartridge holder assembly comprises: a cartridge holder ( 14; 40 ) adapted to receive a cartridge ( 12 ) to be filled with a medicinal product to be dispensed by the drug delivery device, wherein the cartridge holder ( 14; 40 ) comprises at least one through opening at a distal end section to receive a piercing element ( 20 ) being adapted to penetrate a sealing septum ( 22 ) of the cartridge ( 12 ), a constriction member ( 26; 42 ) being adapted to axially abut against the septum ( 22 ) and comprising a through opening ( 34; 52 ) to receive the piercing element ( 20 ), wherein said through opening ( 34; 52 ) is adjustable in diameter.

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Номер записи: 28
14-02-2013 дата публикации

Medicament delivery device

Номер: US20130041327A1
Автор: Mattias Daniel
Принадлежит: SHL GROUP AB

The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.

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Номер записи: 29
21-03-2013 дата публикации

Conformable Actively Multiplexed High-Density Surface Electrode Array for Brain Interfacing

Номер: US20130072775A1
Автор: KIM Dae-Hyeong, LITT BRIAN, ROGERS John, Viventi Jonathan
Принадлежит:

Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveform over large brain surface areas by any of the devices disclosed herein. 1. A method for spatio-temporally electrically interfacing with a brain tissue , the method comprising the steps of: a deformable substrate;', 'a deformable array of electrodes comprising a plurality of electrodes in electrical communication with a plurality of deformable electrical interconnects; and', 'a barrier layer encapsulating at least a portion of the deformable electrical interconnects, wherein the deformable substrate, deformable array of electrodes and the barrier layer provide a net bending stiffness of the device low enough that the device is capable of establishing conformal contact with the brain tissue in the biological environment, wherein the deformable array of electrodes is supported by the barrier layer;, 'providing a conformable device for interfacing with brain tissue in a biological environment, the device comprisingelectrically contacting at least a portion of the plurality of electrodes with the brain tissue in the biological environment by conformally contacting the conformable device with a surface of the brain tissue in the biological environment; andspatio-temporally interfacing the brain tissue with the conformable device to monitor or actuate a spatio-temporal profile over the surface of the brain tissue in electrical contact with the plurality of electrodes.2. The method ...

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Номер записи: 30
21-03-2013 дата публикации

MEDICAL TOOL FOR REDUCED PENETRATION FORCE WITH FEEDBACK MEANS

Номер: US20130072856A1
Автор: Frankhouser Paul L., Mulvihill Maureen L., Park Brian M.
Принадлежит: ACTUATED MEDICAL, INC.

A medical device for reducing the force necessary to penetrate living being tissue using a variety of reciprocating motion actuators, including piezoelectric, voice coil, solenoids, pneumatics or fluidics. The reciprocating actuator drives a penetrating member, such as a needle, through the tissue at a reduced force while the device detects the passage of the penetrating member through the tissue. Upon passage of the penetrating member through the tissue, electrical power to the reciprocating actuator is automatically terminated. One exemplary method for detecting this passage is via a fluid-containing syringe that is coupled to a channel within the penetrating member. Once the penetrating member tip has passed through the living tissue, the fluid within the syringe no longer experiences any pressure and a plunger within the syringe displaces indicating passage of the penetrating member tip. This motion can provide direct tactile feedback to an operator of the medical device or can automatically open a switch providing electrical power to the medical device. Alternatively, a pressure transducer can also monitor the pressure within the penetrating member channel and automatically activate the switch to cut off the electrical power. 1. (canceled)2. A medical device for penetrating living being tissue , said device comprising:a penetrating member which is vibrated to reduce the force needed to penetrate living being tissue;a driving actuator coupled to said penetrating member and causing said vibration when energized; andan electrical power cut off automatically de-energizing said medical device when said penetrating member has passed through said living being tissue, a distal end coupled to said and said penetrating member;', 'a first channel extending to said distal end;', 'at least one piezoelectric element for converting electrical energy into oscillatory motion when energized; and', 'a second channel having a first end in communication with said first channel and ...

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Номер записи: 31
21-03-2013 дата публикации

MEDICAL TOOL FOR REDUCED PENETRATION FORCE WITH FEEDBACK MEANS

Номер: US20130072857A1
Автор: Frankhouser Paul L., Mulvihill Maureen L., Park Brian M.
Принадлежит: ACTUATED MEDICAL, INC.

A medical device for reducing the force necessary to penetrate living being tissue using a variety of reciprocating motion actuators, including piezoelectric, voice coil, solenoids, pneumatics or fluidics. The reciprocating actuator drives a penetrating member, such as a needle, through the tissue at a reduced force while the device detects the passage of the penetrating member through the tissue. Upon passage of the penetrating member through the tissue, electrical power to the reciprocating actuator is automatically terminated. One exemplary method for detecting this passage is via a fluid-containing syringe that is coupled to a channel within the penetrating member. Once the penetrating member tip has passed through the living tissue, the fluid within the syringe no longer experiences any pressure and a plunger within the syringe displaces indicating passage of the penetrating member tip. This motion can provide direct tactile feedback to an operator of the medical device or can automatically open a switch providing electrical power to the medical device. Alternatively, a pressure transducer can also monitor the pressure within the penetrating member channel and automatically activate the switch to cut off the electrical power. 124.-. (canceled)25. A method for reducing the force needed to penetrate living being tissue , said method comprising:vibrating a penetrating member against the living being tissue using a reciprocating actuator that converts electrical energy to reciprocating motion;detecting the passage of said penetrating member through said living being tissue; andautomatically cutting off the electrical energy to said reciprocating actuator when said penetrating member has passed through said living being tissue.26. The method of wherein said step of detecting the passage of said penetrating member through said living being tissue comprises the movement of a plunger within a fluid-containing syringe that is in fluid communication with a channel within ...

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Номер записи: 32
28-03-2013 дата публикации

METHODS FOR IMAGE-GUIDED DELIVERY OF ANESTHETICS INTO THE ANATOMY

Номер: US20130079635A1
Автор: Axelrod Michael, Knostman Richard, Patrick Timothy, Ramey Carribeth
Принадлежит: CARTICEPT MEDICAL, INC.

Devices and systems for injecting fluids, such as anesthetics, to or near nerve tissue or other targeted anatomical location are disclosed herein. A conduit is generally configured to place the fluid delivery module in fluid communication with a needle that is configured to be inserted into the patient's anatomy. One or more medicaments (e.g., anesthetics) and/or other materials contained within containers (e.g., vials) that are secured to the injection system can be selectively delivered into an anatomy through the needle. Nerve stimulation and/or imaging technologies (e.g., ultrasound) can be used to locate a targeted anatomical location. Aspiration can be used to confirm needle location. An overlay on the imaging display can include, in addition to real-time imaging data, data and other information relating to back pressure at or near the needle tip, volumes or other amounts of fluids delivered by and remaining within the system, stimulation level and/or the like. 1. A method of delivering an anesthetic to a target anatomical location of a patient , comprising:positioning a container containing an anesthetic to an injection system;wherein the container is configured to be secured to a loading area of a fluid delivery module of the injection system, said loading area being configured to securely receive various sizes and shapes of the container;wherein the fluid delivery module comprises at least one fluid reservoir within its interior;wherein at least one fluid conduit is configured to be placed in fluid communication with the at least one fluid reservoir, said at least one fluid conduit comprising a distal end;selectively transferring at least a portion of the anesthetic from the container through the at least one fluid conduit via the at least one fluid reservoir;removably securing a stimulation needle along the distal end of the at least one fluid conduit, said stimulation needle being configured to provide electrical stimulation to an anatomy of the patient; ...

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Номер записи: 33
28-03-2013 дата публикации

ELECTRO-MECHANICAL DRUG DELIVERY DEVICE

Номер: US20130079708A1
Автор: "OHare Aidan Michael", Day Shane Alistair, Wimpenny Steven, Yates Barry
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

An electro-mechanical drug delivery device comprises a main body having a distal end and a proximal end. The distal end is configured to attach to a dispense interface. A separable housing that can prevent an administration of a drug by the drug delivery device, the housing configured to cover at least a portion of the distal end of the main body when the separable housing is coupled to the main body of the drug delivery device. A conduction element is provided by the main body and configured for establishing an electrical connection with an electrical connector. Establishment of the electrical connection is prevented when the housing does not cover at least a portion of the distal end of the main body. The electrical connection may be established when the housing covers at least a portion of the distal end of the main body of the drug delivery device. 115-. (canceled)16. A drug delivery device comprising:a main body having a distal end and a proximal end, wherein the distal end is configured to attach to a dispense interface;a separable housing configured to couple to and to decouple from the main body;a conduction element provided by the main body, wherein the device is configured for establishing an electrical connection between the conduction element and an external electrical connector;wherein the device is configured such thatwhen the separable housing is coupled to the main body the administration of a drug by the drug delivery device is prevented, the separable housing covering at least a portion of the distal end of the main body, and establishment of the electrical connection between the conduction element and an external electrical connector is allowed, the separable housing interacting with the main body and enabling access of an external electrical connector to the device andwhen the separable housing is decoupled from the main body the administration of a drug by the drug delivery device is enabled and the establishment of the electrical connection ...

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Номер записи: 34
28-03-2013 дата публикации

AUTOMATIC INJECTION DEVICE

Номер: US20130079718A1
Автор: Bicknell Stephen, Dix Robert, Julian Joseph F., Li Chuan, Shang Sherwin S., Wozencroft Robert Michael
Принадлежит:

Automatic injection device includes a housing, a syringe, a plunger, and a syringe carrier. The housing includes a barrel. The barrel includes an elongated window to allow viewing of contents inside the housing. The syringe is disposed within the housing and has a reservoir. The plunger is at least partially disposed within the syringe and includes a visual indicator. The syringe carrier is disposed within the housing and configured to contain the syringe and displace the syringe within the housing between a first position and a second position. The syringe carrier has a first opening and a second opening. The first opening is configured to align with the window and the reservoir when the syringe carrier is in the first position, and the second opening is configured to align with the window and the visual indicator when the syringe carrier is in the second position. 1. An automatic injection device comprising:a housing having a first end, a second end, and a barrel between the first end and the second end, the barrel comprising an elongated window to allow viewing of contents inside the housing;a syringe disposed within the housing and having a first end, a second end, and a reservoir between the first end and the second end;a plunger at least partially disposed within the syringe and comprising a visual indicator on a portion of the plunger; anda syringe carrier disposed within the housing and configured to contain the syringe and displace the syringe within the housing between a first position and a second position, the syringe carrier having a first opening and a second opening, the first opening configured to align with the window and the reservoir when the syringe carrier is in the first position, and the second opening configured to align with the window and the visual indicator when the syringe carrier is in the second position.2. The automatic injection device of claim 1 , wherein the elongated window has a substantially symmetrical oval shape or pill shape. ...

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Номер записи: 35
18-04-2013 дата публикации

AUTO-INJECTOR

Номер: US20130096512A1
Автор: Barrow-Williams Timothy Donald, Ekman Matthew, Hourmand Yannick
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention refers to an auto-injector, comprising: 115-. (canceled)16. Auto-injector for administering a dose of a liquid medicament (M) , comprising:an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), the housing having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the housing, pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P),', 'operating the syringe to supply the dose of medicament (M), and, 'spring means capable of, upon activationretracting the syringe with the needle into the covered position after delivering the medicament (M),activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection, wherein the spring means is a single drive spring in the shape of a compression spring arranged to be grounded at a distal end in the housing for advancing the needle and for injecting the dose of medicament (M) via a plunger and wherein the drive spring is arranged to have its ground in the housing switched to its proximal end for retracting the syringe, characterized in that the activating means is arranged as a trigger button laterally arranged on the housing.17. Auto-injector according to claim 16 , characterized in that the trigger button is pivoted in the housing and arranged to be rotated when operated.18. Auto-injector according to claim 16 , characterized in that an interlock sleeve is telescoped in the proximal (P) end of the housing claim 16 , the interlock sleeve translatable in longitudinal direction between a proximal position and a distal position and biased in proximal direction (P) in a manner to protrude from the housing in the proximal position ...

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Номер записи: 36
18-04-2013 дата публикации

Automatic injection device with torsional spring

Номер: US20130096513A1
Автор: Christopher James Smith
Принадлежит: Sanofi Aventis Deutschland GmbH

A semi-automatic “fixed” dose injection device is disclosed containing a reservoir of medicament, where a trigger controls the unwinding of a torsional spring to cause a predetermined injection of medicament from the reservoir through a disposable needle.

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Номер записи: 37
25-04-2013 дата публикации

Medicament Delivery Device with Braking Means

Номер: US20130102971A1
Автор: Stephan Olson
Принадлежит: SHL GROUP AB

A medicament delivery device has an elongated housing; a medicament container carrier for a medicament container to which a medicament delivery member is attached, the carrier being slidable in the housing; a trigger unit; a cover unit coaxial and slidable in the housing; a release mechanism adapted to be actuated partly by the trigger unit and partly by movement of the cover unit; a preloaded drive unit releasably connected to the carrier and controlled by the release mechanism for advancing the carrier to a predetermined proximal position in relation to the housing at which the drive unit becomes disconnected from the carrier for advancing a slidable stopper in the container and thereby dispensing the medicament; and a braking mechanism acting between the preloaded drive unit and the release mechanism for controlling the speed of the preloaded drive unit when advancing the slidable stopper in the container.

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Номер записи: 38
25-04-2013 дата публикации

Cartridge Holder and Drug Delivery Device

Номер: US20130102972A1
Автор: Hemmann Kerstine, Jugl Michael, Teucher Axel
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The present invention relates to a cartridge holder for a drug delivery device and to a corresponding drug delivery device, wherein the cartridge holder comprises: 1. A cartridge holder for a drug delivery device comprising:{'b': 36', '12, 'a proximal portion () for receiving a cartridge () filled with a medicinal fluid to be dispensed by the drug delivery device,'}{'b': 34', '24', '25', '30, 'a distal portion () comprising a mount for a piercing assembly (, , ),'}{'b': 12', '30, 'wherein the piercing assembly is adapted to provide a fluid-transferring connection with the inner volume of the cartridge () by way of a piercing element () pointing in distal direction with a pointed free end section; and'}{'b': 40', '42', '44', '12', '36', '34, 'retaining means (; ; ) adapted to substantially prevent the cartridge () from displacing in proximal direction with respect to the proximal portion () and/or distal portion ().'}23634. The cartridge holder according to claim 1 , wherein the proximal portion () and/or the distal portion () comprise a substantially cylindrical shape.340424434. The cartridge holder according to any one of the preceding claims claim 1 , wherein the retaining means (; ; ) extend radially inwardly from an inside wall of the distal portion ().4404244. The cartridge holder according to any one of the preceding claims claim 1 , wherein the retaining means (; ; ) comprise a flexible deformable material.54044. The cartridge holder according to any one of the preceding claims claim 1 , wherein the retaining means comprise radially inwardly protruding struts (; ).640341312. The cartridge holder according to claim 5 , wherein the retaining means () are arranged at a distance from the distal portion's () free end claim 5 , that corresponds to the axial dimensions of a distal neck portion () of the cartridge ().7424234. The cartridge holder according to any one of the preceding claims claim 5 , wherein the retaining means () comprise axially and/or ...

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Номер записи: 39
02-05-2013 дата публикации

BIOINJECTION DEVICE

Номер: US20130110052A1
Автор: Solomon Clifford T., Solomon Theodore C.
Принадлежит:

The bioinjection device has a housing including a pistol grip and an elongated barrel. A trigger is pivotally mounted to the housing. A plunger and needle are slidable between a first position in which the plunger and needle are slidably disposed in the barrel and a second position in which the plunger and needle extend from an opening in the end of the barrel. A retaining member is disposed about the opening at the end of the barrel. A spring-biased actuation mechanism connects the trigger with the plunger and needle. A membranous cartridge containing bone morphogenic protein, antibiotics, and/or other medication is loaded into the retaining member. A surgeon can inject the cartridge into a bone fracture or degenerative bone tissue during surgery to deliver the medicament directly to the affected site. 1. A bioinjection device for delivering medicament into bone tissue , comprising:a housing having a grip and an elongated barrel extending away from the grip, the barrel having a bore;a trigger pivotally mounted on the housing;a plunger having a pointed end, the plunger movable between a first position in which the pointed end is retracted within the bore of the elongated barrel and a second position in which the pointed end extends beyond the bore;a retaining member disposed about an opening of the bore, the retaining member receiving a cartridge containing a medicament; anda spring-biased actuation mechanism coupling the trigger with the plunger, wherein the plunger moves from the first position to the second position when the trigger is actuated.2. The bioinjection device of claim 1 , wherein the plunger pushes the cartridge out of the retaining member and into bone tissue.3. The bioinjection device of claim 1 , further including a needle located within the plunger.4. The bioinjection device of claim 3 , wherein the cartridge has opposed forward and rear ends claim 3 , the rear end being formed from a membranous material so that the needle pierces the membranous ...

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Номер записи: 40
16-05-2013 дата публикации

ELECTRONICALLY MONITORED INJECTION DEVICE

Номер: US20130123685A1
Автор: Buschardt Claus Valentin, Gjødesen Claus Urup, Hansen Kim Ejholm, Jespersen Soren Kragh, Kvolsbjerg Bo, Nielsen Preben Mikael, Pedersen Bennie Peder Smiszek
Принадлежит: Novo Nordisk A/S

Medical injection advice adapted for operating in a dose setting mode and in a dose administration mode, comprising a dosing actuator () reversibly actuatable from a first state for operating the device in the dose setting mode to a second state for operating the device in the dose administration mode, a switch () adapted to sense positional information associated with the dosing actuator, and a controller coupled to the switch arrangement, wherein electronic mode representation is configured to enter dose setting mode after a time delay following detecting the dosing actuator has moved away from said second state or detecting the dosing actuator has moved into said first state. 2. The medical injection device as defined in claim 1 , wherein the dose sensor arrangement comprises a single sensor adapted to detect said positional information associated with the drive member during both dose administration and dose setting operations.3. The medical injection device as defined in claim 1 , wherein the controller is adapted to determine the size of a set dose and adapted to determine the size of an expelled dose.4. The medical injection device as defined in claim 1 , wherein the device further comprises a spring means configured for storing energy during a pre-injection procedure claim 1 , and wherein the drive member claim 1 , during dose administration claim 1 , is forced by the spring means to expel medication from the container when energy previously stored in said spring means is released.5. The medical injection device as defined in claim 4 , wherein the dosing actuator cooperates with the spring means to release energy when the dosing actuator is moved into its second state claim 4 , said release of energy being interrupted when the dosing actuator is returned towards its first state.6. The medical injection device as defined in claim 1 , wherein the time delay is larger than 5 msecs.7. The medical injection device as defined in claim 1 , wherein the injection ...

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Номер записи: 41
16-05-2013 дата публикации

Auto-Injector With A Torsion Spring

Номер: US20130123697A1
Автор: Barrow-Williams Timothy Donald, Ekman Matthew, Hourmand Yannick
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention relates to an auto-injector for administering a dose of a liquid medicament (M), comprising: 115-. (canceled)16. Auto-injector for administering a dose of a liquid medicament (M) , comprising:an elongate outer casing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), the outer casing having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the outer casing, pushing the needle from a covered position inside the outer casing into an advanced position through the orifice and past the proximal end (P),', 'operating the syringe to supply the dose of medicament (M), and, 'spring means capable of, upon activationretracting the syringe with the needle into the covered position after delivering the medicament (M),activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection,characterized in that the spring means is a torsion spring grounded at one end in the outer casing and at the other end in a first gear member rotatable about a longitudinal axis, wherein the first gear member, upon rotation, is arranged for translatively moving a second gear member toward the proximal end (P), the second gear member prevented from rotating and coupled to the stopper in order to push it towards the proximal end (P), wherein the first gear member is engaged with the activating means prior to manual operation in a manner to prevent rotation and disengaged from the activating means upon manual operation.17. Auto-injector according to claim 16 , characterized in that the first gear member is a cam follower tube and that the second gear member is a lead screw tube claim 16 , wherein the lead screw tube is telescoped into the cam follower tube claim 16 , wherein the lead screw tube ...

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Номер записи: 42
23-05-2013 дата публикации

Injection device having an angled tip portion

Номер: US20130131589A1
Автор: Brett R. Johnson, Christopher S. Mudd, Lee F. Powers, Martha E. Llewellyn, Michael J. Prichard, Mitchell H. Babkes, Shaohui Qiu, Zachary P. Dominguez
Принадлежит: Allergan Inc

In one embodiment, the handheld injection device includes a first housing having a first axis and a second housing having a second axis. In one embodiment, the second housing is configured to support a needle. In one embodiment, the first axis and a second axis form an adjustable angle between about 180 degrees and about 90 degrees.

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Номер записи: 43
23-05-2013 дата публикации

GEARBOX

Номер: US20130131595A1
Автор: Barrow-Williams Timothy Donald, Ekman Matthew, Kemp Thomas Mark
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention relates to a gearbox for converting a first translation into a second translation, the gearbox comprising a drive collar connectable to a translative drive means and prevented from rotating with respect to a ground of the drive means, a drive sleeve rotatably arranged at least partially inside the drive collar, engaged to the drive collar by a first screw thread and prevented from translating, wherein a plunger is arranged at least partially inside the drive sleeve, engaged to the drive sleeve by a second screw thread and prevented from rotating. 1. Gearbox for converting a first translation into a second translation , the gearbox comprising a drive collar connectable to a translative drive means and prevented from rotating with respect to a ground of the drive means , a drive sleeve rotatably arranged at least partially inside the drive collar , engaged to the drive collar by a first screw thread and prevented from translating , wherein a plunger is arranged at least partially inside the drive sleeve , engaged to the drive sleeve by a second screw thread and prevented from rotating , characterized in that the first screw thread and the second screw thread are like-handed.2. Gearbox according to claim 1 , characterized in that a pitch angle of the first screw thread and/or the second screw thread vary/varies over the length of the respective screw thread.3. Gearbox according to claim 1 , characterized in that the first screw thread and/or the second screw thread comprise at least one cam track in one of the engaged components and a ball or a follower for each cam track in the other one of the engaged components.4. Auto-injector for administering a dose of a liquid medicament claim 1 , the auto-injector having a distal end (P) and a proximal end (D) with an orifice intended to be applied against an injection site and comprising:an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the ...

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Номер записи: 44
23-05-2013 дата публикации

AUTO-INJECTOR WITH NEEDLE SHROUD AND NEEDLE PROTECTION CAP

Номер: US20130131602A1
Автор: Barrow-Williams Timothy Donald, Ekman Matthew, Kemp Thomas Mark
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention relates to an auto-injector for administering a dose of a liquid medicament (M). A shroud is arranged at least partially inside a housing, the shroud slidable in longitudinal direction between at least a retracted position, in which a hollow injection needle is exposable and an advanced position, in which the needle is covered by the shroud, wherein the shroud is arranged to be locked in the retracted position prior to manual operation of an activation means and wherein the shroud is arranged to be pushed towards the advanced position by a syringe spring when a drive means has been released by the activation means. A protective needle shield is attachable to the needle in a manner to partially protrude beyond the proximal end of the shroud through the orifice with the needle in its advanced position, wherein a syringe carrier is arranged inside the shroud for holding a syringe, the syringe carrier slidable with respect to the shroud, wherein the syringe carrier comprises at least one resilient snap for locking it to the shroud in order to prevent relative axial motion, wherein the snap is arranged to be supportable from inside by the protective needle shield when attached to the needle in order to remain engaged with the shroud and wherein the snap is inwardly biased to disengage from the shroud without support from inside in a manner to automatically disengage upon removal of the protective needle shield thus allowing the syringe and needle to be retracted into the covered position under load of the syringe spring. 1. Auto-injector for administering a dose of a liquid medicament (M) , the auto-injector having a distal end (P) and a proximal end (D) with an orifice intended to be applied against an injection site and comprising:an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), wherein the syringe is slidably arranged with respect to the housing,a drive means ...

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Номер записи: 45
30-05-2013 дата публикации

Injection device

Номер: US20130138049A1
Автор: Andrew Peter Scudamore, Douglas Jennings, Matthew Ekman, Thomas Mark Kemp
Принадлежит: Sanofi Aventis Deutschland GmbH

The invention relates to an injection device, comprising a syringe with a hollow needle and a stopper for sealing the syringe and displacing a medicament (M) stored in the syringe, the injection device further comprising a drive means, a plunger arranged for pushing against the stopper and an arrangement for transferring a translation of the drive means to the plunger, the arrangement comprising an elongate release latch member pivoted at one end which is connected to either the drive means or the plunger, the release latch member having another end for engaging the respective other one of the drive means or the plunger, wherein the release latch member is arranged to have its non-pivoted other end disengaged by rotation due to contact between at least one ramp and another component when the stopper has at least nearly displaced all of a predefined dose of the medicament (M), wherein a length of the release latch member is specified so as to provide a clearance between the plunger and the drive means when the release latch member is engaged in order to allow at least the plunger, the stopper and the hollow needle to be retracted at least far enough to hide the needle inside the syringe or inside a housing after disengaging the release latch member.

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Номер записи: 46
06-06-2013 дата публикации

Package for Delivering Microdoses of Medicament

Номер: US20130144262A1
Автор: Bernd Kuhn, Daniel Wagner
Принадлежит: Sanofi Aventis Deutschland GmbH

A primary package for simultaneously dispensing microdoses of from 5 to 500 microliters of one medicament contained in a medicated module and another medicament contained in an attached injection system is disclosed, where the primary package contains a single dose of medicament contained within a reservoir cavity sealed with closure caps that secure top and bottom septa.

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Номер записи: 47
13-06-2013 дата публикации

Autoinjector with audible indication of completed delivery

Номер: US20130150798A1
Автор: Lionel Maritan
Принадлежит: Becton Dickinson France SA

The present invention relates to a device for automatic injection of a product into an injection site, the device comprising: a container having a displaceable piston; a tubular housing having at least a flexible part which, in a rest state, defines a first opening; a piston rod; and, an intermediate part fixed to the piston rod which defines a diameter larger than the first opening. With sufficient distal displacement of the piston rod, the intermediate part causes the at least a flexible part to deflect outwardly with further distal displacement of the piston rod causing the intermediate part to wholly pass through the first opening with the at least a flexible part returning towards the at rest state, engagement of the at least a flexible part with a surrounding element under force of movement towards the at rest state generating a sound.

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Номер записи: 48
13-06-2013 дата публикации

Auto-Injector

Номер: US20130150800A1
Автор: Ekman Matthew, Jennings Douglas, Kemp Thomas Mark, Scudamore Peter
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention relates to an auto-injector with an interlock mechanism for defining an operation sequence of the auto-injector () in a manner to allow a lateral trigger button () to be operated only when a proximal end (P) of the auto-injector () is pressed against an injection site, wherein a detector means () is arranged inside an elongate housing () of the auto-injector () at the proximal end (P), the detector means () slidable in longitudinal direction and biased by a detector spring () into a position with the detector means () protruding beyond the proximal end (P), wherein a dog () is arranged at the trigger button () and wherein at least one longitudinal bar () is provided, at least one of the bars () slidable in longitudinal direction and coupled to the detector means () for joint movement at least in distal direction (D), wherein a recess () for the dog () is provided in the bar () for allowing the trigger button () to be pressed when the detector means () is being pushed into the auto-injector () and wherein otherwise the dog () is engaged with the bar () in a manner to prevent the trigger button () from being pressed. 1. Auto-injector for administering a dose of a liquid medicament (M) , comprising an elongate housing , a syringe and a trigger button , wherein an interlock mechanism is provided for defining an operation sequence of the auto-injector in a manner to allow the trigger button to be operated only when a proximal end (P) of the auto-injector is pressed against an injection site , wherein a detector means is arranged inside the elongate housing at the proximal end (P) , the detector means slidable in longitudinal direction and biased by a detector spring into a position with the detector means protruding beyond the proximal end (P) , wherein a dog is arranged at the trigger button and wherein at least one longitudinal bar is provided , at least one of the bars slidable in longitudinal direction and coupled to the detector means for joint ...

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Номер записи: 49
13-06-2013 дата публикации

Needle-free intradermal injection device

Номер: US20130150820A1
Автор: Chris CAPPELLO, John W. Bingham, Matt WIXEY
Принадлежит: PharmaJet Inc

A needle-free injection device suitable for delivering a therapeutic substance into the intradermal space of a patient. The needle-free injection device includes a main spring which can be compressed using one or more handles attached to the device to place the needle-free injection device into an armed configuration. Device embodiments may optionally include an injector tube and associated apparatus which may be moved relative to other device structures when the injector is pressed against the skin of a patient with sufficient force. The disclosed operational switches and release mechanisms cooperate to prevent injection unless the device is properly positioned for an injection. Needle-free injection systems and methods of operating a needle-free injection device are also disclosed.

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Номер записи: 50
25-07-2013 дата публикации

Auto-injector

Номер: US20130190721A1
Автор: Matthew Ekman, Thomas Mark Kemp
Принадлежит: Sanofi Aventis Deutschland GmbH

The invention refers to an auto-injector and to a method for operating it, the auto-injector comprising of a tubular chassis; a carrier subassembly comprising a tubular carrier slidably arranged in the chassis, the carrier containing a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe; a wrap-over trigger sleeve arranged over the distal end (D) of the auto-injector; the trigger sleeve extending at least almost over the whole length of the auto-injector; a control spring arranged around the carrier; first interlock means for coupling a proximal end of the control spring to either the carrier for advancing it for needle insertion or to the chassis for needle retraction; second interlock means arranged for releasing the drive spring for injection; third interlock means arranged for coupling the chassis to the carrier for joint axial translation relative to the trigger sleeve; and fourth interlock means arranged for coupling a distal end of the control spring to either the carrier for needle retraction or to the trigger sleeve otherwise.

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Номер записи: 51
01-08-2013 дата публикации

Injection devices

Номер: US20130197442A1
Автор: Jeremy Marshall, Toby Cowe
Принадлежит: OWEN MUMFORD LTD

An injection device includes an elongate housing ( 10 ), a syringe ( 12 ) disposed in the housing, and an internal piston ( 20 ) to express a dose from a needle ( 16 ) at its front end. The injection device further includes a shroud element ( 24 ) movable forwardly relative to the syringe to shroud the needle after use and a latch ( 74 ) movable between a latched state in which it restricts rearward movement of the shroud element, and a release state. The latch is moved to its latch state by a magnetic force ( 56 ).

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Номер записи: 52
01-08-2013 дата публикации

INJECTOR

Номер: US20130197475A1
Автор: Dunn Stephen Terence
Принадлежит: New Injection Systems Ltd

An injector for delivering medicament comprises a collapsible container () for containing the liquid medicament, a normally-closed valve () coupled to the collapsible container () for retaining the liquid medicament within the collapsible container and an injection means () for delivering the liquid medicament from the collapsible container. The liquid medicament is maintained under pressure by a pressurising means () which pressurises the liquid medicament such that it is delivered by the injection means () when the normally-closed valve () is opened. 1. An injector for delivering a liquid medicament comprising ,a collapsible container for containing the liquid medicament, a normally-closed valve coupled to the collapsible container for retaining the liquid medicament within the collapsible container, an injection means coupled to the normally-closed valve for delivering the liquid medicament from the collapsible container, andpressurising means for pressurising the liquid medicament contained within the collapsible container such that the liquid medicament is delivered by the injection means when the normally-closed valve is opened.2. An injector according to in which the injection means is a hollow needle such as a hypodermic needle claim 1 , or in which the injection means is a needleless injection element for injecting medicament into a human or animal body.3. An injector according to in which the collapsible container and the pressurising means are housed within a rigid container.4. An injector according to in which at least a portion of the rigid container is transparent.5. An injector according to in which the rigid container includes a vent to allow displaced air within the rigid container to escape when the collapsible container is filled.6. An injector according to in which the rigid container is hermetically sealed.7. An injector according to in which the rigid container has an inert gas atmosphere surrounding the collapsible container.8. An injector ...

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Номер записи: 53
08-08-2013 дата публикации

Force Transmission Arrangement for Auto-Injector

Номер: US20130204195A1
Автор: Matthew Ekman, Thomas Mark Kemp, Timothy Donald Barrow-Williams
Принадлежит: Sanofi Aventis Deutschland GmbH

The invention relates to a transmission arrangement for controlling a force of a translation, the transmission arrangement comprising a drive collar ( 13 ) connectable to a translative drive means ( 11 ) and prevented from rotating with respect to a ground ( 12 ) of the drive means ( 11 ), a flange face of the drive collar ( 13 ) bearing against a mating flange face of a friction collar ( 20 ), the friction collar ( 20 ) slidable in longitudinal direction and rotationally constrained by engagement in a cam track ( 12.3 ), another flange face of the friction collar ( 20 ) bearing against a mating flange face of a plunger ( 8 ), the plunger ( 8 ) slidable in longitudinal direction and prevented from rotating.

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Номер записи: 54
08-08-2013 дата публикации

Auto-Injector

Номер: US20130204198A1
Автор: Barrow-Williams Timothy Donald, Burnell Rosie, Ekman Matthew
Принадлежит:

The invention relates to an auto-injector for administering a dose of a liquid medicament, comprising 1. Auto-injector for administering a dose of a liquid medicament , comprisinga housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the housing,drive means capable of, upon activation:pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end, andoperating the syringe to supply the dose of medicament, andactivating means arranged to lock the drive means in a loaded state prior to manual operation and capable of, upon manual operation, releasing the drive means for injection,characterized in that the drive means is at least one spring essentially transversally arranged with respect to a longitudinal axis of the syringe at least when in the loaded state.2. Auto-injector according to claim 1 , characterized in that the spring is arranged as a tension spring.3. Auto-injector according to claim 1 , characterized in that a linkage is provided for transmitting movement of the drive means into movement of a plunger connected to the syringe and/or the stopper.4. Auto-injector according to claim 3 , characterized in that the linkage comprises at least one arm with two ends claim 3 , one of the ends having at least one cam follower engaged in a cam track provided in the housing claim 3 , wherein said end is connected to the spring and wherein the other end is hinged to the plunger.5. Auto-injector according to claim 4 , characterized in that in the loaded state the arm is in an over-centre position statically resolving load of the spring into the distal end of the housing.6. Auto-injector according to claim 4 , characterized in that the activating means is a ...

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Номер записи: 55
08-08-2013 дата публикации

AUTO-INJECTOR

Номер: US20130204199A1
Автор: Brereton Simon Francis, Burnell Rosie, Ekman Matthew, Hourmand Yannick, Kemp Thomas
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention refers to an auto-injector for administering a medicament (M), comprising of a chassis, a syringe with a hollow needle and a stopper; a drive spring capable of, upon activation: advancing the needle (), injecting the medicament (M), and retracting the syringe with the needle after delivering the medicament (M); and; activating means arranged to lock and release the drive spring, wherein the drive spring is a compression spring arranged to be grounded at a distal end in the chassis for advancing the needle and for injecting the dose of medicament (M) via a plunger and wherein the drive spring is arranged to have its ground in the chassis switched to its proximal end for retracting the syringe. A refraction sleeve is axially movable arranged around the syringe, wherein the retraction sleeve is fixable in a maximum proximal position for providing ground at the distal end of the drive spring, wherein the retraction sleeve is arranged to take the syringe with it when released and translated in distal direction (D), wherein the compression spring is wrapped over the retraction sleeve with its distal end bearing against a thrust face on the retraction sleeve and with its proximal end bearing against a thrust collar arranged to be coupled to the plunger for joint axial translation for advancing the needle and for injecting the dose of medicament (M) and to decouple from the plunger for retraction. 112-. (canceled)13. Auto-injector for administering a dose of a liquid medicament (M) , comprising:a chassis arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), the auto-injector having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the chassis,a drive spring capable of, upon activation:pushing the needle from a covered position inside the chassis into an advanced position through ...

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Номер записи: 56
08-08-2013 дата публикации

CONTROLLING A MOTOR OF AN INJECTION DEVICE

Номер: US20130204224A1
Автор: Durrani Navid, Eissengarthen Christoph, Muller-Pathle Stephan, Nessel Christian
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

In order to improve the energy efficiency of an injection device , a current is caused to be applied to a motor of the injection device , which is related to a signal from a force sensor . The signal represents a force that is applied by the motor to a plunger of a cartridge 1. A method comprising:receiving a signal from a force sensor, the signal representing a force that is applied by a motor of an injection device to a plunger of a cartridge; andcausing a current that is required to enable the motor to apply the force represented by the signal from the force sensor to the plunger, incremented by a predetermined value, to be applied to the motor.2. The method according to claim 1 , wherein the predetermined value is a predetermined fixed value.3. The method according to claim 1 , wherein the predetermined value is a predetermined fraction of the represented force.4. The method according to claim 1 , wherein the motor is stepper motor.5. The method according to claim 1 , comprising measuring the force that is applied by the motor to the plunger of a cartridge by means of a force sensor that is integrated in the plunger.6. The method according to claim 1 , wherein the motor is configured to apply a force to the plunger by means of a piston rod claim 1 , the method further comprising measuring the force that is applied by the motor to the plunger by means of a force sensor that is one of:integrated in the piston rod; andarranged between the piston rod and the plunger.7. The method according to claim 1 , wherein the force sensor is one of a force sensitive resistor claim 1 , a quantum tunneling composite sensor and a strain gauge.8. An apparatus comprising a controller claim 1 ,the controller being configured to receive a signal from a force sensor, the signal representing a force that is applied by a motor of an injection device to a plunger of a cartridge; andthe controller being configured to cause a current that is required to enable the motor to apply the force ...

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Номер записи: 57
15-08-2013 дата публикации

Medicament Delivery Device Comprising a Manual Activation Member with Improved Gripping and Activation Abilities

Номер: US20130211336A1
Автор: Anders Holmqvist
Принадлежит: SHL GROUP AB

A medicament delivery device includes a housing for a medicament container assembly; a drive member interactively connected to the assembly for expelling a dose of medicament; a dose actuation assembly operably connected to the drive member; and an actuation member interactively connected to the housing and the dose actuation assembly by a gear assembly. The actuation member is movable generally perpendicularly to a longitudinal axis of the device from an initial position, in which the actuation member is positioned within the housing, to a dose-set position, in which a portion of the actuation member protrudes a distance proportional to the set dose from the longitudinal surface of the housing when the dose actuation assembly. The actuation member is manually operated in a direction generally perpendicular to the longitudinal axis of the device from the dose-set position to the initial position for driving the dose actuation assembly and drive member.

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Номер записи: 58
22-08-2013 дата публикации

Mechanism for Preventing Selection of a Dose

Номер: US20130218095A1
Автор: Joseph Butler, Richard James Vincent Avery
Принадлежит: Sanofi Aventis Deutschland GmbH

A dose setting mechanism having a locking mechanism for preventing selection of a dose in a drug delivery device is disclosed. The dose setting mechanism includes a locking mechanism that prevents movement of the dose setting mechanism. When a correct cartridge is inserted into the drug delivery device, the locking mechanism unlocks so as to allow movement of the dose setting mechanism. In one arrangement, the locking mechanism prevents rotation of the dose setting mechanism.

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Номер записи: 59
22-08-2013 дата публикации

AUTOINJECTORS

Номер: US20130218128A1
Автор: Cowe Toby
Принадлежит: OWEN MUMFORD LIMITED

An autoinjector includes a housing for receiving in use in a generally longitudinal loading direction a syringe assembly including a syringe carrier and a syringe, the syringe including a syringe body having a slideable internal piston for expressing a dose contained in the body through a needle at a forward end thereof; a drive mechanism for providing drive for operation of the autoinjector and being disposed generally within the housing and including a mechanical energy source and a winder element for being rotated to charge the energy source, and an input transmission train operational between the syringe assembly and the winder element in use, whereby loading of the syringe assembly into the housing rotates the winder element to charge the energy source. 1. An autoinjector comprising:a housing for receiving in use in a generally longitudinal loading direction a syringe assembly comprising a syringe carrier and a syringe, the syringe including a syringe body having a slideable internal piston for expressing a dose contained in the body through a needle at a forward end thereof;a drive mechanism for providing drive for operation of the autoinjector and being disposed generally within said housing and including a mechanical energy source and a winder element for being rotated to charge the energy source, andan input transmission train operational between the syringe assembly and the winder element in use, whereby loading of said syringe assembly into said housing rotates said winder element to charge the energy source.2. An autoinjector according to claim 1 , wherein said housing includes a passage for receiving in use said syringe assembly.3. An autoinjector according to claim 2 , wherein in use said syringe assembly is inserted forwardly with said passage through a rear end.4. An autoinjector according to claim 2 , wherein in use said syringe assembly is inserted rearwardly into said passage through a front end.5. An autoinjector according to claim 1 , wherein ...

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Номер записи: 60
29-08-2013 дата публикации

APPLICATOR

Номер: US20130226098A1
Автор: MACHIDA Kazuya, OGURA Makoto, Tokumoto Seiji
Принадлежит: HISAMITSU PHARMACEUTICAL CO., INC.

An applicator for applying a microneedle to a skin includes a tubular housing , a piston which transmits a biasing force of a spring to the microneedle, fixation means (a claw receiving portion and claw portions ) for fixing the piston against the biasing force of the spring in the housing , and a cap provided near a first end of the housing . A projecting portion for releasing the piston fixed by the fixation means is provided at a surface of the cap facing the piston . The cap is provided to be freely movable in an extending direction of the housing such that the projecting portion can contact the fixation means when the piston is fixed by the fixation means. 1. An applicator for applying a microneedle to a skin , comprising:a tubular housing;a piston which transmits a biasing force of a biasing member to the microneedle;fixation unit for fixing the piston against the biasing force of the biasing member in the housing; anda cap provided near a first end of the housing, the cap having a release mechanism for releasing the piston fixed by the fixation unit at a surface facing the piston,wherein the cap is provided to be freely movable in an extending direction of the housing such that the release mechanism can contact the fixation unit when the piston is fixed by the fixation unit.2. The applicator according to claim 1 , whereina whole of the cap is housed in the housing.3. The applicator according to claim 1 , whereinan opening at a second end of the housing has the same shape as a shape of the microneedle and has dimensions not smaller than dimensions of the microneedle.4. The applicator according to claim 1 , whereinthe biasing member is a conical spring.5. The applicator according to claim 1 , whereina partition wall for separating a first space housing the release mechanism of the cap and a second space housing the piston from each other is provided in the housing, andthe fixation unit is composed of a rim of a through hole which is formed in the partition wall ...

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Номер записи: 61
29-08-2013 дата публикации

METHOD AND APPARATUS FOR SYRINGE INJECTION OF FLUIDS

Номер: US20130226137A1
Автор: Brown Robert A.
Принадлежит: RELOX MEDICAL, LLC

A system for delivering or withdrawing a fluid to or from the body of a patient in a manner that permits delivery to be controlled based upon feedback from the patient, the system including a syringe assembly providing a syringe operably coupled to one or more sensors adapted to determine one or more corresponding parameters associated with fluid delivery and/or withdrawal, and a monitor adapted to be communicably associated with the one or more sensors of the syringe assembly, and optionally with other sensors or inputs providing additional parameters as well, the monitor comprising one or more read out mechanisms either directly or indirectly corresponding to the one or more fluid delivery/withdrawal parameters, and optionally with one or more of the additional parameters as well. 1. A system for delivering or withdrawing a fluid to or from the body of a patient in a manner that permits delivery to be controlled based upon feedback from the patient , the system comprising:a) a syringe assembly comprising a syringe adapted to contain, and to deliver and/or withdraw, a fluid to and/or from the body, the syringe being operably coupled to one or more sensors adapted to determine one or more corresponding parameters associated with fluid delivery and/or withdrawal, andb) a monitor adapted to be communicably associated with the one or more sensors of the syringe assembly, the monitor comprising one or more read out mechanisms either directly or indirectly corresponding to the one or more fluid delivery/withdrawal parameters.2. A system according to claim 1 , wherein at least one sensor and corresponding parameter associated with the syringe is selected from the group consisting of: rate of fluid delivery or withdrawal claim 1 , amount of fluid delivered or withdrawn at any point in time and/or in total claim 1 , amount of drug or material delivered or withdrawn at any point in time and/or in total claim 1 , concentration of drug or material being delivered claim 1 , ...

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Номер записи: 62
12-09-2013 дата публикации

CONCENTRATED POLYPEPTIDE FORMULATIONS WITH REDUCED VISCOSITY

Номер: US20130236448A1
Автор: Kamerzell Tim, Martin-Moe Sheryl, Wang Yuchang John
Принадлежит: F. HOFFMANN-LA ROCHE AG (ROCHE GLYCART AG)

The present invention relates to polypeptide formulations with reduced viscosity and methods of making and using polypeptide formulations with reduced viscosity. 1. A liquid formulation comprising (a) a polypeptide in an amount of greater than about 50 mg/mL and (b) dimethyl sulfoxide (DMSO) or dimethylacetamide (DMA) in an amount of between about 0.1% to about 50% v/v of the formulation , wherein the formulation has reduced viscosity compared to the same formulation in the absence of DMSO or DMA.2. The formulation of claim 1 , wherein the polypeptide is capable of forming a secondary structure claim 1 , tertiary structure claim 1 , and/or quaternary structure.3. The formulation of claim 2 , wherein the polypeptide is capable of forming a secondary structure.4. The formulation of claim 3 , wherein the secondary structure is a β-sheet.5. The formulation of claim 1 , wherein the polypeptide is hydrophobic.6. The formulation of claim 2 , wherein the polypeptide is about 100 amino acids or greater.7. The formulation of claim 1 , wherein the polypeptide has a molecular weight of greater than about 5 claim 1 ,000 Daltons.8. The formulation of claim 1 , wherein the polypeptide is a therapeutic polypeptide.9. The formulation of claim 1 , wherein the polypeptide is an antibody.10. The formulation of claim 9 , wherein the antibody is a monoclonal antibody.11. The formulation of claim 10 , wherein the monoclonal antibody is a chimeric antibody claim 10 , humanized antibody claim 10 , or human antibody.12. The formulation of claim 10 , wherein the monoclonal antibody is an IgG monoclonal antibody.13. The formulation of claim 9 , wherein the antibody is an antigen binding fragment.14. The formulation of claim 13 , wherein the antigen binding fragment is selected from the group consisting of a Fab fragment claim 13 , a Fab′ fragment claim 13 , a F(ab′)fragment claim 13 , a scFv claim 13 , a Fv claim 13 , and a diabody.15. The formulation of claim 1 , wherein DMSO or DMA is in an ...

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Номер записи: 63
12-09-2013 дата публикации

AUTOMATIC INJECTION DEVICE WITH TEMPORIZING MEANS

Номер: US20130237913A1
Автор: Abry Herve, Carrel Franck, Grunhut Guillaume, Maritan Lionel, Perot Frederic
Принадлежит: BECTON DICKINSON FRANCE S.A.S.

The present invention relates to an injection device including a container, intended for receiving a product and provided with an injection needle and a housing receiving the container. The container is movable relative to the housing between an initial position, an insertion position, and a final position. A collapsible chamber is defined within the housing outside of the container. The chamber is collapsible with the container in the insertion position. The chamber is at least partially defined by a proximal wall and a seal element, wherein, with the container in the initial position, the proximal wall is spaced proximally from the seal element, wherein, with the container in the insertion position, the proximal wall is caused to engage the seal element, and, wherein, with the proximal wall engaging the seal element, the container is caused to move from the insertion position to the final position. 1. A device for automatic injection of a product into an injection site , the injection device comprising:a container having an open proximal end and a substantially closed distal end and being intended to receive a product, an injection needle being provided at said distal end;a housing intended to receive, at least partially, said container, said container being movable relative to said housing between an initial position, in which said needle is contained within said housing, an insertion position, distally spaced relative to said initial position and in which said needle is exposed over a predetermined length, and a final position in which said needle is contained within said housing; and,a collapsible chamber defined within said housing and outside of said container, said chamber being collapsible with said container in said insertion position, said chamber being at least partially defined by a proximal wall and a seal element, wherein, with said container in said initial position, said proximal wall being spaced proximally from said seal element, wherein, with ...

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Номер записи: 64
12-09-2013 дата публикации

Medicament Delivery Device

Номер: US20130237914A1
Автор: Oscar Alexandersson
Принадлежит: SHL GROUP AB

A medicament delivery device includes a generally elongated tubular housing having opposite proximal and distal parts; a needle shield sleeve slidably and coaxially arranged inside the housing with a proximal part of the sleeve protruding a distance outside the proximal part of the housing; a syringe carrier mechanism having a syringe carrier slidably and coaxially arranged within the needle shield sleeve, a syringe having a stopper, a medicament, and a needle, the syringe being coaxially arranged within the syringe carrier; and a holding member connected to the syringe carrier; a first activator member and a second activator member; a drive mechanism adapted to accumulate a drive force for moving the syringe carrier mechanism in a first step and a second step. The second activator member is arranged with an information device for producing audible, visual, and/or tactile feedback to a user about a completed injection.

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Номер записи: 65
12-09-2013 дата публикации

POWER INJECTOR WITH FLOW RATE ASSESSMENT

Номер: US20130237917A1
Автор: Lafferty Sean B., Wagner Gary S.
Принадлежит: Mallinckrodt LLC

A flow rate assessment protocol () that may be utilized by a power injector () is disclosed. This flow rate assessment protocol () monitors a flow rate () during execution of a medical fluid delivery protocol (). This monitored flow rate is compared with a target flow rate (). A comparative output of this monitored flow rate and target flow rate is displayed (), for instance on a graphical user interface (). 1. A power injector , comprising:a powerhead;a syringe plunger driver;a graphical user interface; andcontrol logic configured to: a) execute a medical fluid delivery protocol, wherein said medical fluid delivery protocol comprises at least one phase configured to deliver a programmed volume of a medical fluid at a programmed target flow rate, and wherein said power injector attempts to provide said target flow rate in an execution of said at least one phase; and b) display a first output on said graphical user interface, wherein said first output comprises a numerical representation of a relationship between said target flow rate of said at least one phase of said medical fluid delivery protocol and a current flow rate that exists during an execution of said at least one phase of said medical fluid delivery protocol.2. The power injector of claim 1 , wherein said first output is presented on said graphical user interface only when said current flow rate differs from said target flow rate by more than a predetermined amount.3. The power injector of claim 1 , wherein said first output is presented on said graphical user interface throughout execution of said medical fluid delivery protocol.4. The power injector of claim 1 , wherein said numerical representation comprises a magnitude of said current flow rate and a magnitude of said target flow rate.5. The power injector of claim 4 , wherein said numerical representation further comprises a numerical value for each of said magnitude of said current flow rate and said magnitude of said target flow rate.6. The power ...

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Номер записи: 66
12-09-2013 дата публикации

PREFILLED SYRINGE WITH BREAKAWAY FORCE FEATURE

Номер: US20130237921A1
Автор: Lannan James W., SUND Julius C.
Принадлежит: Antares Pharma, Inc.

A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. The housing includes a retractable guard and an interference component, e.g., a lock ring, adjacent to the retractable guard that interferes with the movement of the retractable guard. An energy source is configured for biasing the plunger to produce an injecting pressure to jet inject the medicament from the fluid chamber through the needle to an injection site. 1. A jet injector , comprising: a container portion defining a fluid chamber containing a medicament;', 'an injection-assisting needle disposed at the distal end of the chamber, having an injecting tip configured for piercing an insertion location, and defining a fluid pathway in fluid communication with the chamber for injecting the fluid from the chamber into an injection site;', 'a plunger movable within the fluid chamber;, 'a prefilled syringe comprising a retractable guard that is movable between a protecting position in which the needle is disposed within the guard and an injecting position in which the tip of the needle is exposed for insertion to the insertion point, and', 'an interference component adjacent to the retractable guard that interferes with the movement of the retractable guard when the retractable component is moved at least partially from the protecting position toward the injecting position;, 'a housing that houses the prefilled syringe and is configured for allowing insertion of the needle at the injection location to an insertion point that is at a penetration depth below the surface, the housing comprisinga syringe support supportively mounting the prefilled syringe in the housing;an energy source configured for biasing the plunger with a force selected to produce an injecting ...

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Номер записи: 67
19-09-2013 дата публикации

Medicament Delivery Device

Номер: US20130245558A1
Автор: Anders Holmqvist
Принадлежит: SHL GROUP AB

The invention relates to a medicament delivery device comprising a housing arranged to receive a medicament container ( 20 ), a drive unit ( 25 ) arranged to act on a stopper ( 27 ) in said medicament container ( 20 ), which drive unit ( 25 ) comprises a torsion drive spring ( 50 ). A dose setting member ( 56 ) is operably connected to said drive unit ( 25 ) such that a manual turning of said dose setting member ( 56 ) causes a tensioning of said torsion drive spring ( 50 ). The device further comprises an activation mechanism ( 76 ) having an activation button ( 94 ) protruding through the distal end of the device, wherein said activation mechanism ( 76 ) is operably connected to said drive unit ( 25 ) such that actuation of said activation mechanism ( 76 ) causes a release of said drive unit ( 25 ) whereby a set dose of medicament is delivered.

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Номер записи: 68
03-10-2013 дата публикации

AUTO-INJECTOR

Номер: US20130261558A1
Автор: Brereton Simon Francis, Ekman Matthew, Hourmand Yannick
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

An auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe with an injection needle, a plunger and a stopper for sealing a syringe barrel and a drive means releasably coupled to the plunger for advancing the syringe in the proximal direction (P) for needle insertion into an injection site and for displacing the dose of medicament (M) into the injection site. The drive means is arranged to be decoupled from the plunger for advancing a needle shroud to a safe position (PS) to surround the injection needle after the injection. According to the invention, the drive means bears against a thrust collar arranged to be releasably coupled to the plunger through a ramped engagement of a first tongue and a first recess so as to rotate the thrust collar on translation in proximal direction (P). At least one longitudinal gap (G G) is provided for guiding at a first and/or second protrusion of the thrust collar to prevent a rotation of the thrust collar. A circumferential gap (G) is arranged to allow the thrust collar to rotate out of engagement to the plunger on removal of the auto-injector from the injection site. 115-. (canceled)16. Auto-injector for administering a dose of a liquid medicament (M) , comprising:a substantially cylindrical housing arranged to contain a pre-filled syringe with an injection needle, a plunger and a stopper for sealing a syringe barrel anda drive means releasably coupled to the plunger for advancing the syringe in the proximal direction (P) for needle insertion into an injection site and for displacing the dose of medicament (M) into the injection site,wherein the drive means is arranged to be decoupled from the plunger for advancing a needle shroud to a safe position (PS) to surround the injection needle after the injection,characterized in that the drive means bears against a thrust collar arranged to be releasably coupled to the plunger through a ...

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Номер записи: 69
10-10-2013 дата публикации

Back-End Device for an Auto-Injector and Auto-Injector

Номер: US20130267897A1
Автор: Ekman Matthew, Jennings Douglas, Kemp Thomas Mark
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

According to the invention, a back-end device of an auto-injector adapted to be attached to a packaged syringe comprises 113-. (canceled)15. Back-end device according to claim 14 , characterized in that a rotary damper is arranged to exert a velocity dependant torque upon the rotary sleeve to restrict the maximal rotation speed of the rotary sleeve.16. Back-end device according to claim 15 , characterized in that the rotary damper comprises a first cog wheel that engages a second cog wheel of the rotary sleeve.17. Back-end device according to claim 14 , characterized in that a sleeve latch that is rotationally affixed to the chassis is arranged to engage the rotary sleeve in a locked position to prevent the rotary sleeve from rotating within the chassis and wherein the sleeve latch is arranged to be translated in the distal direction into an unlocked position claim 14 , wherein the sleeve latch in the unlocked position disengages the rotary sleeve to allow for a rotation of the rotary sleeve within the chassis.18. Back-end device according to claim 17 , characterized in that the sleeve latch is biased towards the locked position by a biasing element.19. Back-end device according to claim 14 , characterized in that the release element comprises a chamfered surface that abuts against a projection of the rotary sleeve claim 14 , so that upon manual actuation the release element exerts a torque upon the rotary sleeve to release the engagement of the plunger follower with the cam surface.20. Back-end device according to claim 14 , characterized in that the drive means is substantially arranged within the hollow plunger.22. Auto-injector according to claim 21 , characterized in that a syringe retainer slidably arranged with respect to a transfer sleeve releasably mounts the packaged syringe to the chassis of the back-end device.23. Auto-injector according to claim 22 , characterized in that the transfer sleeve is adapted to rest on the skin of a patient during the ...

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Номер записи: 70
10-10-2013 дата публикации

AUTO-INJECTOR

Номер: US20130267898A1
Автор: Ekman Matthew, Hourmand Yannick
Принадлежит:

According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical chassis arranged to contain a pre-filled syringe with a syringe barrel filled with the medicament (M), an injection needle and a stopper for sealing the syringe barrel, a needle shroud slidably arranged within the chassis and adapted to rest on the skin of a patient receiving an injection, a plunger adapted to translate the stopper to expel the dose of the medicament (M) through the injection needle, a coupling shroud slidably arranged within the chassis and releasably coupled to the plunger and a drive means. Upon release, the drive means is capable of driving the coupling shroud from a first position (I) in a proximal direction (P). The proximal translatory movement of the coupling shroud with respect to the chassis translates the pre-filled syringe in the proximal direction (P) to expose the injection needle, depresses the plunger connected to the stopper into the syringe barrel to expel the dose of medicament (M) and advances the needle shroud to a safe position (PS) to surround the injection needle after the injection. The coupling shroud is arranged to be decoupled from the plunger at a second position (II). The needle shroud is arranged to prevent the decoupling of plunger and coupling shroud when the needle shroud is in a retracted position (PR), whereas the needle shroud is arranged to allow for the decoupling of plunger and coupling shroud when the needle shroud is moved from the retracted position (PR) towards the safe position (PS). 113-. (canceled)14. Auto-injector for administering a dose of a liquid medicament (M) , comprisinga substantially cylindrical chassis arranged to contain a pre-filled syringe with a syringe barrel filled with the medicament (M), an injection needle and a stopper for sealing the syringe barrel,a needle shroud slidably arranged within the chassis and adapted to rest on the skin of a patient ...

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Номер записи: 71
10-10-2013 дата публикации

Non-detachable reservoir holder for a drug delivery device

Номер: US20130267905A1
Автор: Axel Teucher, David Sanders, Joseph Butler, Michael Jugl, Richard James Vincent Avery, Thomas Frederick Osman
Принадлежит: Sanofi Aventis Deutschland GmbH

Disclosed herein are various examples of a drug delivery system having a non-detachable reservoir holder. The drug delivery system includes a dose setting mechanism and a reservoir holder attached to the dose setting mechanism, wherein the reservoir holder is configured to partially detach from the dose setting mechanism to allow for (i) insertion of a reservoir into the reservoir holder without being fully detached from the dose setting mechanism and (ii) removal of the reservoir from the reservoir holder without being fully detached from the dose setting mechanism.

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Номер записи: 72
17-10-2013 дата публикации

AUTO-INJECTOR

Номер: US20130274655A1
Автор: Ekman Matthew, Jennings Douglas, Kemp Thomas
Принадлежит:

The invention relates to an auto-injector (A) for administering a dose of a liquid medicament, comprising of a substantially tubular front-end device adapted to contain a syringe with an injection needle and a barrel containing the dose of the medicament and comprising a needle shroud adapted to rest on the skin of a patient receiving an injection and a reusable back-end device comprising of a housing, a plunger connected to or adapted to engage a stopper providing a fluid tight seal for a distal end of the barrel, a motor for displacing the plunger connected to the stopper, wherein the front-end device is attachable to the back-end device, wherein the needle shroud is slidably arranged with respect to the injection needle and wherein an interlock switch is capable of detecting an axial position (PA, PR) of the needle shroud. 112-. (canceled)13. Auto-injector (A) for administering a dose of a liquid medicament , comprising:a substantially tubular front-end device adapted to contain a syringe with an injection needle and a barrel containing the dose of the medicament and comprising a needle shroud adapted to rest on the skin of a patient receiving an injection and a housing,', {'b': 3', '3, 'a plunger connected to or adapted to engage a stopper (.) providing a fluid tight seal for a distal end of the barrel,'}, 'a motor for displacing the plunger connected to the stopper,, 'a reusable back-end device comprisingwherein the front-end device is attachable to the back-end device, wherein the needle shroud is slidably arranged with respect to the injection needle and wherein an interlock switch is capable of detecting an axial position (PA, PR) of the needle shroud.14. Auto-injector (A) according to claim 13 , characterized in that the needle shroud comprises an extension arm that is adapted to interact with the interlock switch so as to communicate the axial position (PA claim 13 , PR) of the needle shroud to the back-end device of the auto-injector (A).15. Auto-injector ...

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Номер записи: 73
17-10-2013 дата публикации

AUTO-INJECTOR

Номер: US20130274662A1
Автор: Barrow-Williams Timothy Donald, Ekman Matthew, Hourmand Yannick
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slibably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P). 113-. (canceled)14. Auto-injector for administering a dose of a liquid medicament (M) , comprisinga substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M),a needle shroud slibably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection,a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS),a rotating collar rotatably arranged within the housing,wherein the needle shroud in the safe position (PS) surrounds the injection needle and wherein the rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P) towards the safe position (PS).15. Auto-injector according to claim 14 , characterized in that the rotating collar comprises a pin that engages a helical recess formed into the needle shroud.16. Auto-injector according to claim 14 , characterized in that the ...

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Номер записи: 74
17-10-2013 дата публикации

AUTO-INJECTOR

Номер: US20130274668A1
Автор: Barrow-Williams Timothy Donald, Ekman Matthew
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention refers to an auto-injector comprising: 115-. (canceled)16. Auto-injector for administering a dose of a liquid medicament (M) , comprising:a body arranged to contain a syringe with a hollow injection needle and a stopper for sealing the syringe and displacing the medicament (M), the body having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the body,torsion spring capable of, upon activation:pushing the needle from a covered position inside the body into an advanced position through the orifice and past the proximal end (P),operating the syringe to supply the dose of medicament (M), andactivating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection,wherein the torsion spring is grounded at one end in the body and at the other end in a first gear member rotatable about a longitudinal axis, wherein the first gear member, upon rotation, is arranged for translating a second gear member toward the proximal end (P), the second gear member prevented from rotating and arranged to be coupled to the stopper in order to push it towards the proximal end (P), wherein the first gear member is engaged with the activating means prior to manual operation in a manner to prevent rotation and disengaged from the activating means upon manual operation,characterized in that a ratchet wheel is arranged on the first gear member, the ratchet wheel having a number of circumferentially arranged teeth, wherein the activating means comprise at least one locking feature for engaging the ratchet wheel in a manner to prevent rotation and wherein the locking feature is arranged to allow rotation on manual operation.17. Auto-injector according to claim 16 , characterized in that the activating means comprises a wrap-over trigger sleeve arranged over the ...

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Номер записи: 75
17-10-2013 дата публикации

MODULAR INJECTION DEVICE

Номер: US20130274670A1
Автор: Mudd Christopher, Powers Lee, Qiu Shaohui, Tezel Ahmet
Принадлежит:

A modular injection device for administration of dermal filler compositions is provided. The injection device may include a handheld injector unit including a drive unit, the drive unit configured to apply an extrusion force to a fluid; a control unit remote from the injector unit, the control unit configured to control the drive unit; and a cable configured to connect the control unit to the injector unit. 1. A modular injection system for administration of dermal filler compositions , the system comprising:a handheld injector unit including a grippable housing including a distal end having a coupling portion, and a drive unit contained within the housing,a separate control unit, remote from the injector unit, the control unit including a controller/processor configured to control the drive unit; anda cartridge, couplable to the coupling portion of the grippable housing, and containing an injectable fluid;the injector unit including a movable plunger driven by the drive unit and extendable in a distal direction to cause extrusion of the injectable fluid from the cartridge when the cartridge is coupled to the coupling portion.2. The system of wherein the control unit further includes an input device configured to receive user input to program the controller/processor to set an injection rate for the fluid from the cartridge.3. The system of wherein the control unit is configured to be secured to a wrist of a user of the system.4. The system of further comprising a wrist strap removably connectable to the control unit.5. The system of wherein the control unit is removably connectable to the wrist strap by magnetic elements.6. The system of further comprising a charging dock configured to receive both the injector unit and the control unit.7. The system of further comprising a cable connecting the control unit to the injector unit.8. The system of wherein the injector unit including substantially opposing triggers configured to enable ejection of the cartridge from ...

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Номер записи: 76
17-10-2013 дата публикации

AUTO-INJECTOR

Номер: US20130274671A1
Автор: Ekman Matthew, Jennings Douglas, Kemp Thomas
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention relates to a front-end device of an auto-injector (A) for administering a dose of a liquid medicament, comprising of a support sleeve with a first screw thread adapted to engage a housing of a back-end device of the auto-injector (A) to attach the front-end device to the back-end device and an outer sleeve mounted onto a support sleeve of the front-end device by a second screw thread, wherein the front-end device is adapted to receive a syringe with an injection needle and a barrel containing the dose of the medicament and wherein the direction of rotation of the first screw thread is opposite to the direction of rotation of the second screw thread. 114-. (canceled)15. Front-end device of an auto-injector (A) for administering a dose of a liquid medicament , comprisinga support sleeve with a first screw thread adapted to engage a housing of a back-end device of the auto-injector (A) to attach the front-end device to the back-end device andan outer sleeve mounted onto a support sleeve of the front-end device by a second screw thread,wherein the front-end device is adapted to receive a syringe with an injection needle and a barrel containing the dose of the medicament and wherein the direction of rotation of the first screw thread is opposite to the direction of rotation of the second screw thread.16. Front-end device according to claim 15 , characterized in that a syringe retainer adapted to receive the pre-filled syringe is slidably arranged with respect to the support sleeve between a first position (I) with the needle covered inside the support sleeve and a second position (II) with the needle exposed for injection claim 15 , wherein the outer sleeve is arranged to abut against an assembly lock that comprises a second inward projection arranged to latch to a first flange of the syringe retainer to prevent an axial translation of the syringe retainer in the first position (I) towards the second position (II).17. Front-end device according to claim 16 ...

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Номер записи: 77
17-10-2013 дата публикации

AUTO-INJECTOR WITH A TORSION SPRING

Номер: US20130274676A1
Автор: Ekman Matthew, Kemp Thomas Mark
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention relates to an auto-injector for administering a dose of a liquid medicament (M), comprising of an elongate housing arranged to contain a syringe with a hollow needle and a bung for sealing the syringe and displacing the medicament (M), the elongate housing having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the housing; spring means capable of, upon activation, pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P) as well as operating the syringe to supply the dose of medicament (M); and activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection. The spring means is a torsion spring grounded at one end in the housing and at the other end in a first gear member rotatable about a longitudinal axis but axially fixed wherein the first gear member, upon rotation, is arranged for translatively moving a second gear member, the second gear member prevented from rotating and coupled to the bung in order to push it towards the proximal end (P), wherein the first gear member is engaged with the activating means prior to manual operation in a manner to prevent rotation and disengaged from the activating means upon manual operation. The activating means is a trigger button, arranged at a distal end (D) of the housing and operable by being pressed in proximal direction (P). 114-. (canceled)15. Auto-injector for administering a dose of a liquid medicament (M) , comprising:an elongate housing arranged to contain a syringe with a hollow needle and a bung for sealing the syringe and displacing the medicament (M), the elongate housing having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein ...

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Номер записи: 78
17-10-2013 дата публикации

Front End for an Auto-Injector

Номер: US20130274677A1
Автор: Ekman Matthew, Jennings Douglas, Kemp Thomas
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention relates to a front end for an auto-injector, the front end comprising a syringe with an injection needle and a stopper, further comprising an outer sleeve arranged to be attached to an auto-injector back end comprising a drive means for advancing the syringe and needle in a proximal direction for needle insertion and for advancing the stopper within the syringe for injection, wherein the syringe is slidably arranged within a transfer sleeve which is slidably arranged in the outer sleeve, wherein the transfer sleeve is biased in the proximal direction against the syringe, wherein a locking mechanism is arranged for limiting a proximal extension of the transfer sleeve from the outer sleeve to an initial position in an initial state, wherein the locking mechanism is arranged to allow the transfer sleeve to be extended into a needle safe position covering the advanced needle beyond the initial position after having been translated in the distal direction into a depressed position. 111-. (canceled)12. Front end for an auto-injector , the front end comprising a syringe with an injection needle and a stopper , further comprising an outer sleeve arranged to be attached to an auto-injector back end comprising a drive means for advancing the syringe and needle in a proximal direction for needle insertion and for advancing the stopper within the syringe for injection , wherein the syringe is slidably arranged within a transfer sleeve which is slidably arranged in the outer sleeve , wherein the transfer sleeve is biased in the proximal direction against the syringe , wherein a locking mechanism is arranged for limiting a proximal extension of the transfer sleeve from the outer sleeve to an initial position in an initial state , wherein the locking mechanism is arranged to allow the transfer sleeve to be extended into a needle safe position covering the advanced needle beyond the initial position after having been translated in the distal direction into a depressed ...

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Номер записи: 79
24-10-2013 дата публикации

AUTO-INJECTOR

Номер: US20130281929A1
Автор: Ekman Matthew, Jennings Douglas, Kemp Thomas
Принадлежит:

The invention relates to a compression connection means for an auto-injector (A), wherein the compression connection means adapted to attach a front-end device of the auto-injector (A) to a back-end device of the auto-injector (A) comprises of an annular mounting sleeve that is axially displaceable parallel to a longitudinal axis (X) between a locked position (L) and an unlocked position, a mounting sleeve spring biasing the mounting sleeve towards a locked position (L), at least one latch arm connected to one of either the front-end device or the back-end device, wherein the latch arm is deflectable in a radial direction, wherein the mounting sleeve in the locked position (L) is arranged to prevent the radial deflection of the latch arm and wherein the mounting sleeve in the unlocked position allows for a radial deflection of the latch arm, so as to allow the latch arm to be deflected on assembly or disassembly of the front-end device to the back-end device and to latch to or unlatch from the other of the front-end device or the back-end device. 110-. (canceled)11. A compression connection means for an auto-injector (A) , wherein the compression connection means adapted to attach a front-end device of the auto-injector (A) to a back-end device of the auto-injector (A) comprisesan annular mounting sleeve that is axially displaceable parallel to a longitudinal axis (X) between a locked position (L) and an unlocked position,a mounting sleeve spring biasing the mounting sleeve towards a locked position (L),at least one latch arm connected to one of either the front-end device or the back-end device,wherein the latch arm is deflectable in a radial direction, wherein the mounting sleeve in the locked position (L) is arranged to prevent the radial deflection of the latch arm and wherein the mounting sleeve in the unlocked position allows for a radial deflection of the latch arm, so as to allow the latch arm to be deflected on assembly or disassembly of the front-end ...

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Номер записи: 80
24-10-2013 дата публикации

Injection devices

Номер: US20130281933A1
Автор: Jeremy Marshall, Toby Cowe
Принадлежит: OWEN MUMFORD LTD

An injection device includes an elongate housing ( 10 ); a syringe ( 12 ) disposed in the housing and having an internal piston ( 20 ) to express a dose from a needle ( 16 ) at its front end; a trigger device ( 52 ) for, in use, activating the internal piston, and a cap ( 66 ) that, in a fitted configuration, fits over at least part of the elongate housing and prevents activation of the trigger device.

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Номер записи: 81
24-10-2013 дата публикации

Auto-Injector

Номер: US20130281935A1
Автор: Barrow-Williams Timothy Donald, Ekman Matthew, Kemp Thomas Mark
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention refers to an auto-injector for administering a dose of a liquid medicament, comprising: 115-. (canceled)16. Auto-injector for administering a dose of a liquid medicament , comprising:an elongate outer casing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the outer casing having a distal end and a proximal end with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the outer casing,spring means capable of, upon activation:pushing the needle from a covered position inside the outer casing into an advanced position through the orifice and past the proximal end,operating the syringe to supply the dose of medicament, andretracting the syringe with the needle into the covered position after delivering the medicament,activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection,wherein the spring means is a torsion spring grounded at one end in the outer casing and at the other end in a first gear member rotatable about a longitudinal axis, wherein the first gear member, upon rotation, is arranged for translatively moving a second gear member toward the proximal end, the second gear member prevented from rotating and arranged to be coupled to the stopper in order to push it towards the proximal end, wherein the first gear member is engaged with the activating means prior to manual operation in a manner to prevent rotation and disengaged from the activating means upon manual operation,characterized in that at least one skin contact trigger element is arranged at the proximal end of the outer case, the skin contact trigger element translatable in longitudinal direction between a proximal position and a distal position and biased in proximal direction in a manner to protrude from the outer casing in the ...

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Номер записи: 82
24-10-2013 дата публикации

AUTO-INJECTOR

Номер: US20130281936A1
Автор: Ekman Matthew, Jennings Douglas, Kemp Thomas
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

Auto-injector for delivering a liquid medicament (M), the auto-injector comprising an elongate housing having a loading bay configured to receive a packaged syringe, wherein the loading bay is configured to be laterally accessible for inserting or removing the packaged syringe, wherein a sliding door is slidably arranged over the housing in a manner to reveal the loading bay in a distal position and to cover the loading bay in a proximal position. 113-. (canceled)14. Auto-injector for delivering a liquid medicament (M) , the auto-injector comprising an elongate housing having a loading bay configured to receive a packaged syringe , wherein the loading bay is configured to be laterally accessible for inserting or removing the packaged syringe , wherein a sliding door is slidably arranged over the housing in a manner to reveal the loading bay in a distal position and to cover the loading bay in a proximal position.15. Auto-injector according to claim 14 , characterized in that the packaged syringe comprises a syringe with a hollow injection needle and a stopper for sealing the syringe and displacing the liquid medicament (M) claim 14 , wherein a drive spring is arranged in the housing for advancing the syringe and the needle in proximal direction (P) for needle insertion into an injection site and for injecting the medicament (M) through the needle claim 14 , wherein the sliding door exhibits a door rack gear in mesh with a drive gear which is in mesh with a drive reset rack such that the sliding door and the drive reset rack translate in opposite directions claim 14 , wherein the drive reset rack is arranged to compress the drive spring on translation in distal direction (D).16. Auto-injector according to claim 15 , characterized in that a plunger is arranged for transferring load from the drive spring to the syringe and/or to the stopper claim 15 , wherein the plunger comprises a plunger rack gear claim 15 , wherein a plunger gear is in mesh with the drive gear and ...

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Номер записи: 83
31-10-2013 дата публикации

INJECTION DEVICE WITH CAMMED RAM ASSEMBLY

Номер: US20130289491A1
Автор: GOUDREAU Paul M., HOEFT Peter A., Kramer Thomas E., RUST Matthew H., SADOWSKI Peter L., SUND Julius C.
Принадлежит:

An exemplary embodiment of the present disclosure can provide an injector including a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger member can include a trigger member having a retainer portion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom and a trigger engagement member configured to engage the retainer portion of the trigger member in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation between the trigger engagement member and the retainer portion from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retainer portion to allow the energy source to fire the ram. 1. An injector , comprising: a trigger member having a retainer portion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a trigger engagement member configured to engage the retainer portion of the trigger member in a pre-firing condition;', 'an energy source associated with the ram for powering the ram to expel the medicament; and', 'a user-operable firing-initiation member operable for causing an axial rotation between the trigger engagement member and the retainer portion from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retainer portion to allow the energy source to fire the ram., 'a trigger mechanism including2. The injector of claim 1 , further comprising an injector housing claim 1 , wherein the firing initiation member includes a skin-contacting member disposed at a distal end of the injector that is movable proximally with respect to the housing when a force is applied to the skin-contacting member at the ...

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Номер записи: 84
07-11-2013 дата публикации

Needle assembly for drug pump

Номер: US20130296785A1
Автор: Oz Cabiri
Принадлежит: Medimop Medical Projects Ltd

A needle assembly adapted for fluid communication with a cartridge containing a substance to be delivered to a subject, the needle assembly characterized by a biasing device ( 70 ) arranged to apply a biasing force on a needle ( 28, 116 ) to cause the needle ( 28, 116 ) to protrude outwards of a housing ( 30, 112 ) to pierce the subject, and biasing device release apparatus ( 60 ) including a biasing device arrestor ( 62 ) that initially blocks movement of the biasing device ( 70 ) and which releases the biasing device ( 70 ) when the safety latch ( 32, 122 ) moves to a position that permits moving the needle holder ( 26, 118 ) to cause the needle ( 28, 116 ) to protrude outwards of the housing ( 30, 112 ).

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Номер записи: 85
07-11-2013 дата публикации

NEEDLE SAFETY ARRANGEMENT AND METHOD FOR OPERATING IT

Номер: US20130296794A1
Автор: Brereton Simon Francis, Ekman Matthew
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention refers to a needle safety arrangement for protecting a hollow injection needle of a syringe after an injection, the needle safety arrangement comprising: 115-. (canceled)16. Needle safety arrangement for protecting a hollow injection needle of a syringe after an injection , the needle safety arrangement comprising:a needle sheath having essentially the shape of a hollow cylinder arranged to surround the needle, the needle sheath slidable in longitudinal direction with respect to the syringe and biased in proximal direction (P),a sheath linkage, slidable in longitudinal direction,a syringe carrier for holding the syringe, the syringe and syringe carrier arranged for joint axial translation and rotation relative to the needle sheath,wherein the sheath linkage comprises means for restricting translation in proximal direction (P) with respect to the syringe by abutting against the syringe carrier, wherein in an initial state the sheath linkage is abutted against the syringe carrier and latched to the needle sheath for joint axial translation, wherein the syringe carrier exhibits at least one cam on its circumference, wherein the cam is arranged to de-latch the needle sheath from the sheath linkage on rotation of the syringe carrier so as to release the needle sheath for being translated in proximal direction (P) and cover the needle.17. Needle safety arrangement according to claim 16 , characterized in that the syringe carrier exhibits at least one slot on its circumference and that the latched needle sheath and sheath linkage form at least one spline claim 16 , each spline arranged for engaging one of the slots in the initial position so as to prevent rotation of the syringe carrier claim 16 , wherein the spline is arranged to be disengaged from the slot on translation of the needle sheath in distal direction (D) from the initial position.18. Needle safety arrangement according to claim 16 , characterized in that the syringe carrier is arranged to be ...

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Номер записи: 86
07-11-2013 дата публикации

Auto-Injector

Номер: US20130296795A1
Автор: Brereton Simon Francis, Ekman Matthew, Kemp Thomas Mark
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention refers to a shuttering mechanism for controlling translation of a longitudinally moveable component within an elongate housing, the shuttering mechanism comprising at least one set of castellations on the housing and at least one resilient arm associated with the longitudinally moveable component, the resilient arm having a dog resiliently biased towards the castellations so as to engage between or behind the castellations and block the translation, wherein a respective shutter arm is arranged alongside the set of castellations, the shutter arm having a number of consecutive ramped protrusions spaced from each other, wherein the castellations and the ramped protrusions have the same pitch, wherein a profiled surface is formed by the castellations and the ramped protrusions, wherein the shutter arm is moveable in longitudinal direction with respect to the set of castellations, wherein the shutter arm has at least one locking position with its ramped protrusions essentially in phase with the castellations thus allowing the dog of the resilient arm to catch between or behind the castellations and wherein the shutter arm has at least one unlocking position with its ramped protrusions out of phase with the castellations in such a manner that the ramped protrusions prevent the dog from engaging with the castellations or disengage them thus allowing translation of the longitudinally moveable component. 1. Shuttering mechanism for controlling translation of a longitudinally moveable component within an elongate housing , the shuttering mechanism comprising at least one set of castellations on the housing and at least one resilient arm associated with the longitudinally moveable component , the resilient arm having a dog resiliently biased towards the castellations so as to engage between or behind the castellations and block the translation , wherein a respective shutter arm is arranged alongside the set of castellations , the shutter arm having a number of ...

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Номер записи: 87
07-11-2013 дата публикации

Auto-Injector

Номер: US20130296796A1
Автор: Brereton Simon Francis, Burnell Rosie, Ekman Matthew, Hourmand Yannick, Kemp Thomas Mark
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention refers to an auto-injector for delivering a liquid medicament, comprising: 114-. (canceled)15. Auto-injector for delivering a liquid medicament , comprising:an elongate housing arranged to contain a syringe with a hollow injection needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the housing,spring means capable of, upon activation:pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end for insertion into the injection site,operating the syringe to inject the dose of medicament, andadvancing a needle shroud over the needle for providing needle safety,activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means, wherein the spring means is a single drive spring in the shape of a compression spring grounded distally in the housing and proximally bearing against a thrust collar arranged to transmit load from the spring means via a plunger to the syringe and/or the stopper for needle insertion and injection, wherein the plunger is engageable to the thrust collar for joint axial translation, wherein the plunger is disengageable from the thrust collar on relative rotation so as to allow the thrust collar to be advanced further by the drive spring in order to engage the needle shroud for advancing it over the needle.16. Auto-injector according to claim 15 , characterized in that the needle shroud is biased in a proximal direction so as to be in an initial position protruding from the proximal end in an initial state claim 15 , wherein the activating means comprises a trigger button interlocked to the needle shroud in such a manner that the needle shroud prevents manual operation of ...

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Номер записи: 88
21-11-2013 дата публикации

METHOD FOR ADMINISTERING A FLUID ACTIVE SUBSTANCE FROM A MULTI-CHAMBER AMPOULE

Номер: US20130310739A1
Автор: Galbraith Sofia, Hirschel Juerg, Moser Ulrich, Thompson Ian
Принадлежит: TecPharma Licensing AG

An administering device for administering an active substance from a multi-chamber container comprising a first chamber holding a solid active substance and a second chamber holding a dissolving liquid for the active substance, wherein the administering device comprises a mixing device for mixing the active substance with the dissolving liquid and a housing accommodating the mixing device, the container being moveable relative to the housing, and the administering device further comprising a first indicator for indicating a position of the container relative to the housing upon completion of a mixing step, and a second indicator for indicating a position of the container relative to the housing upon completion of a venting step. 116-. (canceled)17. An administering device for administering an agent from a multi-chamber carpule with at least a first chamber containing a solid agent and a second chamber containing a dissolving liquid for the agent , the administering device having a proximal end and a distal end and comprising a housing and a mixing mechanism for mixing the agent and dissolving liquid , wherein the mixing mechanism comprises a holder element for accommodating the carpule , the holder element rotatably moveable relative to the housing for being inserted into the housing and for mixing the agent and dissolving liquid , the multi-chamber carpule fixed relative to the holder element during mixing , the administering device further comprising a display system comprising at least a first visual display for indicating a position of the multi-chamber carpule relative to the housing when a mixing operation has ended , at least a second visual display for indicating a position of the carpule relative to the housing when a priming operation has ended , and a catch mechanism for forming a releaseable catch position between the holder element and the housing which permits rotating the holder element to move the holder element in the proximal direction relative to ...

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Номер записи: 89
21-11-2013 дата публикации

DETENT MECHANISM

Номер: US20130310744A1
Автор: Brereton Simon Francis, Burnell Rosie, Ekman Matthew, Kemp Thomas
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

The invention relates to a detent mechanism for controlling translation between two components in a longitudinal direction (P, D), the detent mechanism comprising at least one clip on one of the components arranged to be in a ramped engagement with a recess in the other one of the components in an initial state in such a manner that translation between the components is constrained and that application of a translative force between the components in one longitudinal direction (P, D) with the clip engaged with the recess deflects the clip out of the recess when a predetermined value of the translative force, at least depending on the resilience of the clip, is overcome so as to allow translation between the components. 115-. (canceled)16. Detent mechanism for controlling translation between two components in a longitudinal direction (P , D) , the detent mechanism comprising at least one clip on one of the components arranged to be in a ramped engagement with a recess in the other one of the components in an initial state in such a manner that translation between the components is constrained and that application of a translative force between the components in one longitudinal direction (P , D) with the clip engaged with the recess deflects the clip out of the recess when a predetermined value of the translative force , at least depending on the resilience of the clip , is overcome so as to allow translation between the components.17. Detent mechanism according to claim 16 , characterized in that at least one clip is arranged as a resilient beam on one of the components biased towards the other component claim 16 , the clip extending from the one component in the proximal direction (P) claim 16 , the clip arranged to abut the other component in the proximal direction (P) preventing translation claim 16 , wherein a ramp feature on a third component is slidable in the longitudinal direction (P claim 16 , D) in a manner to engage the clip in a ramped engagement ...

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Номер записи: 90
21-11-2013 дата публикации

AUTOINJECTORS

Номер: US20130310745A1
Автор: Latham David, Wozencroft Robert
Принадлежит: OWEN MUMFORD LIMITED

An autoinjector includes a body (), a syringe () or cartridge disposed within the body, and a plunger () moveable during operation between a first and a second position to effect an injection, the plunger including a transverse passage () containing a moveable magnetic element () of a magnetic pair, the body including another magnetic element () at a position such that, on the plunger reaching and/or nearing its second position, the magnetic attraction therebetween causes a sound-emitting impact, the plunger () including a magnetic keeper element () mounted adjacent the transverse passage and adapted to hold the movable magnetic element () against movement until attraction by the other magnetic pair element (), wherein the keeper element () is disposed on the longitudinal axis. 1101213606668546072685472. An autoinjector comprising a body ( , ) , a syringe () or cartridge disposed within said body , and an elongate plunger () movable longitudinally during operation between a first and a second position to effect an injection , the plunger including a transverse passage () containing a moveable magnetic element () of a magnetic pair , the body including another magnetic element () at a position such that , on said plunger reaching and/or nearing its second position , the magnetic attraction therebetween causes a sound-emitting impact , the plunger () including a magnetic keeper element () mounted adjacent said transverse passage and adapted to hold the movable magnetic element () against movement until attraction by the other magnetic pair element () , wherein said keeper element () is disposed on said longitudinal axis.268. An autoinjector according to claim 1 , wherein the moveable magnetic element () comprises a magnetic ball.354. An autoinjector according to claim 1 , wherein the magnetic element () associated with said body comprises a disc magnet.472. An autoinjector according to claim 1 , wherein said keeper () element comprises a keeper element of ferro- ...

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Номер записи: 91
21-11-2013 дата публикации

AUTOINJECTORS

Номер: US20130310746A1
Автор: Wozencroft Robert
Принадлежит: OWEN MUMFORD LIMITED

An autoinjector includes a rear body assembly () connected to a front body assembly, wherein the rear body assembly () contains a drive mechanism ( . . . ) and the front body assembly contains a syringe () or cartridge with a needle at its forward end, the front body assembly including a viewing window () through which at least part of the contents of the syringe () or cartridge are visible, a removable cap () fitted to the forward end of the front body assembly the rear body assembly and the removable cap having respective aligned cut-away regions together defining a frame for the viewing window. Also disclosed is a modular scheme which uses a common platform for the provision of a range of autoinjectors of different fill volumes, with only the length of the plunger (), and the axial extent of the cut out varying between different versions. 1101210601322131478114. An autoinjector comprising a rear body assembly () connected to a front body assembly () , wherein said rear body assembly () contains a drive mechanism ( . . . ) and said front body assembly contains a syringe () or cartridge with a needle at its forward end , the front body assembly including a viewing window () through which at least part of the contents of the syringe () or cartridge are visible , a removable cap () fitted to the forward end of the front body assembly , the rear body assembly and the removable cap having respective aligned cut-away regions ( , ) together defining a frame for said viewing window.21378. An autoinjector according to claim 1 , adapted to receive one of a series of syringes () or cartridges of different dose volume claim 1 , and wherein the axial extent of at least one () of said cut-away regions varies according to the fill volume.3. An autoinjector according to claim 2 , wherein the axial extent of the cut-away region in the rear body assembly is variable.460. An autoinjector according to claim 1 , wherein said drive mechanism includes a plunger () of length selected ...

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Номер записи: 92
21-11-2013 дата публикации

VIBRATIONAL DEVICE FOR FAT INSERTION DURING FAT TRANSPLANTATION

Номер: US20130310749A1
Автор: Del Vecchio Daniel A.
Принадлежит: Lipovera, LLC

An injection cannula includes a hand-held mechanical motorized device to improve delivery of fat and facilitate dispersion at a recipient site. The injection cannula may, for example be a cannula for injecting fat in a cosmetic surgical procedure for fat transplantation such as percutaneous injection or injection directly into the subcutaneous fat. An electric motor, pneumatic motor, or other mechanism may be used to provide vibration. 1. A device , comprising:a gripping portion;a vibrating motor;an injection cannula mechanically coupled to the vibrating motor; anda syringe coupled in fluid communication with the injection cannula through the vibrating motor for the injection of a material in the syringe through the injection cannula.2. The device of claim 1 , further comprising fat contained within the syringe for use in a fat transplantation procedure.3. The device of claim 1 , wherein the motor is an electric motor.4. The device of claim 1 , wherein the motor is a pneumatic motor.5. The device of claim 1 , wherein the injection cannula facilitates the flow of fat and egress of fat from a tip of the injection cannula.6. The device of wherein the gripping portion is shaped and sized for a human hand.7. The device of wherein the motor is housed within the gripping portion.8. The device of further comprising a vibration-absorbing material between the motor and the gripping portion to isolate vibrational forces therebetween.9. The device of further comprising a control controlling a vibration of the motor.10. The device of wherein the control is positioned on the gripping portion of the device.11. The device of wherein the control includes at least one of a button claim 9 , a switch claim 9 , and a slider.12. The device of wherein the control includes a display configured to provide information to a user relating to operation of the motor.13. The device of further comprising a pump for controllable delivery of the material from the syringe to the injection cannula.14. ...

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Номер записи: 93
21-11-2013 дата публикации

AUTO-INJECTOR

Номер: US20130310757A1
Автор: Brereton Simon Francis, Burnell Rosie, Ekman Matthew, Kemp Thomas
Принадлежит: Sanofiaventis Deutschland GMBH

An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case, a carrier subassembly comprising a tubular carrier slidably arranged inside the case, where the carrier adapted to contain a syringe with a hollow injection needle. The injector also has, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for advancing the needle beyond a proximal end of the auto-injector, and a trigger button is used for releasing the control spring on actuation. 115-. (canceled)16. An auto-injector for administering a dose of a liquid medicament (M) , comprising:an elongate case,a carrier subassembly comprising a tubular carrier slidably arranged inside the case, the carrier adapted to contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier,a control spring arranged around the carrier for translating the carrier in a proximal direction (P) for advancing the needle beyond a proximal end of the auto-injector,a trigger button for releasing the control spring on actuation,wherein the drive spring biases the plunger in the proximal direction (P) against the carrier, wherein at least one resilient arm is arranged on either the carrier or the plunger and in a ramped engagement to the other of the carrier or the plunger so as to disengage them under load of the drive spring, wherein a peg is arranged to be coupled to the case at least after actuation of the trigger button so as to be positioned to support the resilient arm preventing disengagement of the carrier from the plunger and thus release of the drive spring when the carrier is in a distal position, ...

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Номер записи: 94
28-11-2013 дата публикации

AUTO-INJECTOR

Номер: US20130317427A1
Автор: Brereton Simon Francis, Burnell Rosie, Ekman Matthew, Kemp Thomas
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. A trigger button is distally arranged in or on the case, wherein the trigger button is initially coupled to the case in a manner to protrude distally from the case and interlocked to the chassis in a manner preventing the trigger button from disengaging the case. 114-. (canceled)15. An auto-injector for administering a dose of a liquid medicament (M) , comprising:an elongate case arranged to be held by a user,a tubular chassis telescopable in the case and biased against the case so as to protrude from the case,a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe,a trigger button distally arranged in or on the case,wherein the trigger button is initially coupled to the case in a manner to protrude distally from the case and interlocked to the chassis in a manner preventing the trigger button from disengaging the case and thus preventing actuation of the trigger button in an initial position, wherein the case is arranged to translate in the proximal direction (P) against the bias relative to the chassis thereby also translating the trigger button releasing the interlock to the chassis so as to allow actuation of the trigger button, wherein the trigger button is arranged to lock in a more proximal position on actuation.16. The auto-injector according to claim 15 , characterized in that a carrier subassembly is arranged comprising a tubular carrier slidably arranged relative to the chassis inside the case claim 15 , the carrier adapted to contain the syringe with the hollow injection ...

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Номер записи: 95
28-11-2013 дата публикации

AUTO-INJECTOR

Номер: US20130317428A1
Автор: Brereton Simon Francis, Burnell Rosie, Ekman Matthew, Kemp Thomas
Принадлежит: SANOFI-AVENTIS DEUTSCHLAND GMBH

An auto-injector for administering a dose of a liquid medicament (M) is presented having a tubular chassis telescopable in an elongate chassis, a carrier subassembly comprising a tubular carrier slidably arranged partially inside the chassis and inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. The auto-injector also has a control spring arranged around the carrier, a needle insertion control mechanism for coupling a proximal end of the control spring to either the carrier for advancing it for needle insertion or to the chassis, wherein the needle insertion control mechanism comprises a first collar biased by the control spring in a proximal direction (P), wherein at least one fifth clip is arranged on one of the chassis or the first collar initially abutting a block on the other of the chassis or the first collar. 114-. (canceled)15. An auto-injector for administering a dose of a liquid medicament (M) , comprising:a tubular chassis telescopable in an elongate chassis,a carrier subassembly comprising a tubular carrier slidably arranged partially inside the chassis and inside the case, the carrier adapted to contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier,a control spring arranged around the carrier,a needle insertion control mechanism for coupling a proximal end of the control spring to either the carrier for advancing it for needle insertion or to the chassis,wherein the needle insertion control mechanism comprises a first collar biased by the control spring in a proximal direction (P), wherein at least one fifth clip is arranged on one of the chassis or the first collar ...

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Номер записи: 96
28-11-2013 дата публикации

NEEDLE ASSISTED JET INJECTION DEVICE HAVING REDUCED TRIGGER FORCE

Номер: US20130317431A1
Автор: GOUDREAU Paul M., HOEFT Peter A., Krämer Thomas, Madsen Patrick, RUST Matthew H., SADOWSKI Peter L., SUND Julius C., Travanty Michael
Принадлежит: Antares Pharma, Inc.

An exemplary embodiment of an injector includes a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger mechanism can include a floating trigger member having a retaining portion, a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a floating trigger engagement member configured to engage the retaining portion of the floating trigger member when the floating trigger member is in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation of the floating trigger member from the pre-firing condition to a firing condition in which the floating trigger engagement member is released from the retaining portion to allow the energy source to fire the ram. 1. An injector , comprising: a floating trigger member having a retaining portion, and', 'a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a floating trigger engagement member configured to engage the retaining portion of the floating trigger member when the floating trigger member is in a pre-firing condition;, 'a trigger mechanism'}an energy source associated with the ram for powering the ram to expel the medicament; anda user-operable firing-initiation member operable for causing an axial rotation of the floating trigger member from the pre-firing condition to a firing condition in which the floating trigger engagement member is released from the retaining portion to allow the energy source to fire the ram.2. The injector of claim 1 , further comprising an injector housing claim 1 , wherein the firing initiation member includes a skin-contacting member disposed at a distal end of the injector that is movable proximally with respect to the ...

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Номер записи: 97
28-11-2013 дата публикации

AUTOINJECTOR

Номер: US20130317432A1
Автор: FABIEN David, MANSENCAL Antoine, WALTER Matthieu
Принадлежит: APTAR FRANCE SAS

An autoinjector having a lower body () receiving a reservoir, a piston, a needle, a central body () fixed to the lower body, an actuating sleeve () having a contact end to contact the body of the user and displaceable in the lower body between a projected position, in which the actuating sleeve at least partially projects out of the lower body and an actuation position, in which the actuating sleeve is axially displaced towards the interior of the lower body. The actuating sleeve includes a flexible tab () adapted to deform on the one hand radially and on the other hand laterally relative to the central body when the actuating sleeve is displaced from its projected position towards its actuation position then from its return actuation position towards its projected position. 11011011111011101110111101. An autoinjector comprising a lower body () receiving a reservoir , said reservoir containing fluid product and comprising a piston and a needle , such as a pre-filled syringe (A) , a central body () fixed to said lower body () and an actuating sleeve () comprising a contact end designed to make contact with the body of the user , said actuating sleeve () being displaceable in said lower body () between a projected position , in which said actuating sleeve () at least partially projects out of said lower body () and an actuation position , in which said actuating sleeve () is axially displaced towards the interior of said lower body () , wherein said actuating sleeve () comprises a flexible tab () adapted to deform on the one hand radially and on the other hand laterally relative to said central body () when said actuating sleeve is displaced from its projected position towards its actuation position then from its return actuation position towards its projected position.21101111. The autoinjector according to claim 1 , in which said flexible tab () is deformed radially when said actuating sleeve () is moved from its projected position claim 1 , prior to actuation claim ...

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Номер записи: 98
28-11-2013 дата публикации

AUTOINJECTOR

Номер: US20130317433A1
Автор: FABIEN David, MANSENCAL Antoine, WALTER Matthieu
Принадлежит: APTAR FRANCE SAS

An autoinjector having a body () receiving a reservoir, a piston, a needle, an actuating sleeve () having a contact end to contact the body of the user and displaceable relative to the body between projected positions, in which the actuating sleeve at least partially projects out of the body receiving a reservoir, and an actuation position, in which the actuating sleeve is axially displaced towards the interior of the body receiving a reservoir. The actuating sleeve is in a first projected position prior to actuation of the autoinjector and in a second projected position after actuation of the autoinjector. The actuating sleeve or the body receives a reservoir having a flexible tab adapted to deform laterally relative to the actuating sleeve and/or relative to the body receiving a reservoir when the actuating sleeve is displaced from its first projected position towards its actuation position then from its return actuation position towards its second projected position. 11010201010112011101120111010201010112011101020101011201110102010101120111011201110102010111021101011201110102010. An autoinjector comprising a body (; ) receiving a reservoir , said reservoir containing fluid product and comprising a piston and a needle , such as a pre-filled syringe (A) , said autoinjector comprising an actuating sleeve (; ) comprising a contact end designed to make contact with the body of the user , said actuating sleeve (; ) being displaceable relative to said body receiving a reservoir (; ) between projected positions , in which said actuating sleeve (; ) at least partially projects out of said body receiving a reservoir (; ) , and an actuation position , in which said actuating sleeve (; ) is axially displaced towards the interior of said body receiving a reservoir (; ) , said actuating sleeve (; ) being in a first projected position prior to actuation of the autoinjector and in a second projected position after actuation of the autoinjector , wherein one of said actuating ...

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Номер записи: 99
28-11-2013 дата публикации

AUTOINJECTEUR

Номер: US20130317434A1
Автор: FABIEN David, MANSENCAL Antoine, WALTER Matthieu
Принадлежит: APTAR FRANCE SAS

An autoinjector having a lower body () receiving a reservoir, a piston, a needle, an actuating sleeve () with a contact end to contact the user. The actuating sleeve is displaceable between projected positions and an actuation position, being in a first projected position prior to actuation of the autoinjector. The autoinjector also having an injection device () and an injection lock. The actuating sleeve is automatically returns to the second projected position when the user removes the autoinjector from his body and is locked in this second projected position. The autoinjector includes an external shell () having a display window for indicating the actuation sequences, at least one display window () indicating to the user that the injection of the fluid product is finished. 1101010. An autoinjector comprising a lower body (; ) receiving a reservoir , said reservoir containing fluid product and comprising a piston and a needle , such as a pre-filled syringe (A) , said autoinjector comprising:{'b': 11', '1011', '11', '1011', '11', '1011, 'an actuating sleeve (; ) provided with a contact end designed to make contact with the body of the user, said actuating sleeve (; ) being displaceable between projected positions and an actuation position, said actuating sleeve (; ) being in a first projected position prior to actuation of the autoinjector and in a second projected position after actuation of the autoinjector,'}{'b': 5', '8', '1005', '1008, 'injection means (, ; , ) to inject said fluid product through said needle when said needle is in the injection position,'}{'b': 5', '8', '1005', '1008, 'an injection lock to block said injection means (, ; , ),'}{'b': 11', '1011', '11', '1011, 'said actuating sleeve (; ) being automatically returned to said second projected position when the user removes the autoinjector from his body, said actuating sleeve (; ) being locked in this second projected position, preventing any other actuation of the autoinjector,'}{'b': 22', '1022 ...

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Номер записи: 100