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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 12733. Отображено 100.
12-01-2012 дата публикации

Energy based devices and methods for treatment of patent foramen ovale

Номер: US20120010608A1
Принадлежит: Terumo Corp

Methods and apparatus for treatment of patent foramen ovale (PFO) provide for applying energy to tissues adjacent the PFO with a catheter device to substantially close the PFO acutely. Apparatus generally includes a catheter device having at least one energy transmission member at or near its distal end configured to apply energy to PFO tissues to acutely, substantially close the PFO. Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like. Some embodiments of a catheter device fuirther include one or more tissue apposition members near the distal end for helping bring PFO tissues together, such as a PFO covering member, a vacuum applying member and/or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

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19-01-2012 дата публикации

Method for transurethral delivery of thermal therapy to tissue

Номер: US20120016273A1
Автор: Chris J. Diederich
Принадлежит: UNIVERSITY OF CALIFORNIA

An apparatus for applying thermal energy to a prostate gland, comprising a support tube having a longitudinal passageway, a power lead channeled through the longitudinal central passageway and an ultrasound crystal disposed around at least part of the support tube. The ultrasound crystal is coupled to the power lead which provides the power to energize the ultrasound crystal and generate ultrasound energy providing thermal therapy to the prostate gland. The ultrasound crystal further includes inactivated portions for reducing ultrasound energy directed to the rectal wall of the patient. A sealant is disposed in contact with the ultrasound crystal allowing vibration necessary for efficient ultrasound energy radiation for the thermal therapy of the prostate gland.

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26-01-2012 дата публикации

Method For Operating A Medical Robot, A Medical Robot, And A Medical Workstation

Номер: US20120022552A1
Автор: Thomas Neff
Принадлежит: KUKA LABORATORIES GmbH

A method for operating a medical robot, a medical robot, and a medical work station. The invention relates to a method for operating a medical robot ( 2 ). The robot ( 2 ) includes a robot arm ( 5 ) having a plurality of members ( 7 ), drives ( 15 ) provided for moving the members ( 7 ), and an attaching device ( 9 ). The robot ( 2 ) also has a control device ( 6 ) for activating the drives ( 15 ), and a sound generating device ( 3 ) attached to the attaching device ( 9 ), which is provided to apply sound to a living organism ( 10 ), in particular a high-intensity focused ultrasound.

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02-02-2012 дата публикации

Ultrasound device for medical applications

Номер: US20120029352A1
Принадлежит: SIEMENS AG

An ultrasound device for medical application has a transducer formed by a number of transducer elements. The transducer elements are carried on a flexible support that allows the transducer elements to be configured to an examination subject. A measurement device determines, for each transducer element, a distance or a rotation thereof with respect to a reference point. The reference point can be a point that is physically a part of the ultrasound device, or can be a virtual reference point.

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02-02-2012 дата публикации

Compact ultrasound transducer assembly and methods of making and using the same

Номер: US20120029393A1
Автор: Warren Lee
Принадлежит: General Electric Co

A compact ultrasound transducer assembly is provided. The ultrasound transducer assembly comprises a compact housing, a therapy transducer disposed in the compact housing, and an interchangeable Fresnel lens having a flat surface and a structured surface. The Fresnel lens is disposed in the compact housing so that the flat surface of the Fresnel lens faces the therapy transducer. The structured surface of the Fresnel lens is disposed in a direction away from the therapy transducer, and the Fresnel lens is removably coupled to the therapy transducer, the compact housing, or both.

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02-02-2012 дата публикации

Motion compensation for non-invasive treatment therapies

Номер: US20120029396A1
Принадлежит: Individual

Treatment of moving tissue may be facilitated by identifying voxels within a volume of the tissue, associating treatment-related attributes with the voxels, and shifting positions of the voxels based on the tissue movement. One or more treatment parameters may then be altered based on the treatment-related attributes of the shifted voxels.

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08-03-2012 дата публикации

Method and system for ultrasound treatment with a multi-directional transducer

Номер: US20120059288A1
Принадлежит: Guided Therapy Systems LLC

A method and system for ultrasound treatment utilizing a multi-directional transducer to facilitate treatment, such as therapy and/or imaging or other tissue parameter monitoring, in two or more directions. In accordance with an exemplary embodiment, a multi-directional transducer comprises at least two transduction elements configured to provide for ultrasound energy, such as radiation, acoustical energy, heat energy, imaging, positional information and/or tissue parameter monitoring signals in two or more directions. The transduction elements can comprise various materials for providing ultrasound energy or radiation, such as piezoelectric materials, with and without matching layers. In addition, the transduction elements can be configured for substantially uniform, focused and/or defocused radiation patterns, as well as for single, multiple-element and/or multiple-element array configurations. In addition, an exemplary multi-directional transducer can comprise multiple elements, either side by side, stacked or in an array.

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05-04-2012 дата публикации

Hands-Free Operator-Independent Transcranial Ultrasound Apparatus and Methods

Номер: US20120083718A1
Принадлежит: Cerevast Therapeutics Inc

Disclosed is a “hands-free”, autonomously operating, battery-powered apparatus with electronic programmable actuation circuitry for non-invasive ultrasonic treatment of ischemic stroke, microatheromas of the cerebral vasculature, intracranial hypertension, and other cerebrovascular pathologies such as hypoperfusion associated with migraine. The apparatus is provided with registration members to facilitate stereotactic placement of the headset on the skull with respect to target intracranial anatomy. Once fitted in place on the skull and activated, the device does not require clinical intervention during operation; does not need skilled technical adjustment of the waveform patterns; and achieves therapeutic results with power consumption of less than 400 mAmp-hr, thus permitting extended portable operation without external power and eliminating the need for assisted cooling. Using a device of the invention, transcranial ultrasound may be self-administered. The device has application in therapeutic methods, such as methods for treating stroke or migraine, for non-invasively augmenting drug action, and for release or dispersal of endogenous neurovascular mediators.

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19-04-2012 дата публикации

Ultrasound transducer and cooling thereof

Номер: US20120095371A1
Автор: Ariel Sverdlik, Or Shabtay
Принадлежит: Cardiosonic Ltd

An ultrasonic transducer device for producing ultrasonic beams comprises a body vibratable at ultrasonic frequencies and an extensive surface for beam emanation, the device configured to produce an unfocused, or alternatively a focused, power beam for tissue ablation, the power beam being produced by vibration over the body of the transducer and emanating from the extent of the surface, whereby the extensive surface becomes subject to convective cooling when immersed in a fluid by a chimney effect set up by said unfocused beam.

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03-05-2012 дата публикации

Apparatus and method for ultrasonic spine treatment

Номер: US20120109019A1
Принадлежит: Smith and Nephew Inc

The present invention relates to an apparatus for therapeutically treating bone structure using ultrasound, and more particularly, the present invention relates to an apparatus with an attachment structure for treating bone injuries or a variety of musculoskeletal injuries and/or problems.

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17-05-2012 дата публикации

Catheter guidance of external energy for renal denervation

Номер: US20120123243A1
Автор: Roger Hastings
Принадлежит: Boston Scientific Scimed Inc

An in vivo apparatus includes a flexible shaft having a proximal end, a distal end, and a length sufficient to access a patient's renal artery relative to a percutaneous access location. An energy guide apparatus is provided at the distal end of the shaft and dimensioned for deployment within the renal artery. An ex vivo apparatus includes an arrangement configured to localize the energy guide apparatus within the renal artery, and an energy source configured to direct ablative energy to target tissue located a predetermined distance from the localized energy guide apparatus. The target tissue includes perivascular renal nerve tissue adjacent the renal artery.

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17-05-2012 дата публикации

Minimally Invasive Access for Renal Nerve Ablation

Номер: US20120123303A1
Принадлежит: Boston Scientific Scimed Inc

An elongated flexible medical device is inserted into a patient's body via a natural orifice, and advanced through the natural orifice to a location proximate innervated tissue that influences renal sympathetic nerve activity. The medical device can be advanced into a body organ and to a location within the organ proximate the innervated tissue. The organ may comprise an organ of the gastrointestinal tract or urinary tract. The medical device may be advanced through and beyond an access hole in a wall of the organ, and situated at a location proximate the innervated tissue. One or both of imaging and ablation energy is delivered from a distal end of the medical device to the innervated tissue. Innervated renal tissue can be ablated using various forms of energy, including RF energy, ultrasound energy, optical energy, and thermal energy.

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24-05-2012 дата публикации

Ultrasound detecting device having function of confirming irradiation position, and method thereof

Номер: US20120130240A1
Принадлежит: Teijin Pharma Ltd

Provided is an ultrasound fracture detection device capable of accurately irradiating an ultrasound pulse to a target object, the device being characterized by being provided with an ultrasound wave irradiating transducer, a signal receiving transducer which receives a reflected wave of an ultrasound wave irradiated from the ultrasound wave irradiating transducer, a signal, storage unit which stores a received signal, and a display unit which displays an analysis program that analyzes a stored signal, a determination program that performs determination from the result of the analysis and/or performs determination from the stored signal, and the result of the analysis and/or the result of the determination, wherein the determination program performs the determination using that information relating to the received signal varies depending on the reflector within a living organism.

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31-05-2012 дата публикации

Method and apparatus for treatment of adipose tissue

Номер: US20120136282A1
Принадлежит: SYNERON MEDICAL LTD

The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.

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21-06-2012 дата публикации

Systems and methods for automatically identifying and segmenting different tissue types in ultrasound images

Номер: US20120157842A1
Принадлежит: General Electric Co

A system for providing non-invasive ultrasound based treatment to a region of interest is provided. The system comprises an imaging unit for imaging one or more tissue types in the region of interest, an image processing unit that is configured to identify the one or more tissue types in the region of interest, an ultrasound transducer that is configured to focus an ultrasound beam to ablate at least a portion of the identified tissues, and a controller unit that controls a delivery of the ultrasound beam to the region of interest.

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21-06-2012 дата публикации

System for controlling tissue ablation using temperature sensors

Номер: US20120157890A1
Принадлежит: Biosense Webster Israel Ltd

Body tissue ablation is carried out by inserting a probe into a body of a living subject, urging the probe into contact with a tissue in the body, generating energy at a power output level, and transmitting the generated energy into the tissue via the probe. While transmitting the generated energy the ablation is further carried out by determining a measured temperature of the tissue and a measured power level of the transmitted energy, and controlling the power output level responsively to a function of the measured temperature and the measured power level. Related apparatus for carrying out the ablation is also described.

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28-06-2012 дата публикации

Endoluminal fold creation

Номер: US20120165604A1
Принадлежит: Ethicon Endo Surgery Inc

Devices and methods are provided for forming one or more plications in the walls of a body cavity. In particular, endoscopic devices and methods are provided for forming and/or securing endoluminal tissue folds to reduce the volume of the gastric cavity. An end effector that includes a tissue receiving cavity can be delivered to a desired surgical site to allow a tissue fold to be formed within the tissue receiving cavity. A fastener can be used to secure the adjacent layers of tissue that form the tissue fold. The tissue folds can be effective to limit the stomach's capacity and create a feeling of satiety.

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28-06-2012 дата публикации

Endoluminal fold creation

Номер: US20120165842A1
Принадлежит: Ethicon Endo Surgery Inc

Devices and methods are provided for forming one or more plications in the walls of a body cavity. In particular, endoscopic devices and methods are provided for forming and/or securing endoluminal tissue folds to reduce the volume of the gastric cavity. An end effector that includes a tissue receiving cavity can be delivered to a desired surgical site to allow a tissue fold to be formed within the tissue receiving cavity. A fastener can be used to secure the adjacent layers of tissue that form the tissue fold. The tissue folds can be effective to limit the stomach's capacity and create a feeling of satiety.

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05-07-2012 дата публикации

Mr imaging guided theraphy

Номер: US20120172708A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

The invention relates to a therapeutic system which comprises an ultrasound therapy unit ( 1, 518 ) arranged to insonify at least a portion of a body ( 2, 508 ) of a patient with high intensity ultrasound and a MR imaging unit ( 3, 500 ) arranged to acquire MR signals from the portion of the body ( 2, 508 ) and to reconstruct a thermographic MR image from the MR signals. It is an object of the invention to enable MR guided high intensity focused ultrasound (HIFU) treatment, in which temperature values within critical anatomic regions containing fat can be monitored. The invention proposes that the therapeutic system further comprises an ultrasound diagnostic unit ( 5, 518 ) which is arranged to acquire ultrasound signals from the portion of the body ( 2, 508 ) and to derive at least one local temperature value from the ultrasound signals.

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12-07-2012 дата публикации

Ischemic Stroke Therapy

Номер: US20120179073A1
Автор: Henry Nita
Принадлежит: Individual

A method for delivering ultrasound energy to a patient's intracranial space includes the steps of forming a hole in a patient's skull, locating an ultrasound transmitter near or into the hole, and transmitting ultrasound from the transmitter into the intracranial space, wherein the Mechanical Index of ultrasound energy traveling through cerebral tissue in the intracranial space is less than 1.0, the power intensity delivered to a target tissue in the intracranial space is greater than 50 mW/cm 2 and less than 200 mW/cm 2 , and the frequency of the transmitted ultrasound is within the range between 500 kHz and 2 MHz. Microbubbles, aspirin, both microbubbles and aspirin, and a mixture of microbubbles and aspirin, can also be delivered into the intracranial space.

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26-07-2012 дата публикации

Low temperature hyperthermia system for therapeutic treatment of invasive agents

Номер: US20120190911A1
Принадлежит: Actium Biosystems LLC

The Low Temperature Hyperthermia System illuminates nano-particles, which are implanted in a living organism at the locus of the cancer or into the cancer cells, with a precisely determined energy field. This energy field ensures that the optimal cancer cell and cancer stem cell destruction temperature of 42° C. is not exceeded in the tissue, which minimizes the release of Heat Shock Proteins and cancer stem cells. The Low Temperature Hyperthermia System uses specially designed nano-particles that exhibit a specific temperature rise in a given illumination energy field and then have no further temperature rise even if the applied illumination energy field increases beyond the optimal level. Alternatively, the nano-particles exhibit a tightly controlled temperature rise based on a pre-determined illumination energy field strength. This innovative approach can also use radiation and/or chemotherapy in conjunction with the nano-particle illumination to kill the majority of the cancer cells.

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09-08-2012 дата публикации

Ultrasound power supply for an ultrasound transducer

Номер: US20120203098A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

An ultrasound power supply ( 100 ) adapted for supplying electrical power for driving an ultrasound transducer ( 202, 702 ) in contact with a subject ( 208 ), wherein the ultrasound power supply comprises:—a communications interface ( 102 ) adapted for receiving a first temperature measurement of a first volume ( 211, 318 ) of the subject and a second temperature measurement of a second volume ( 214, 320 ) of the subject;—a controller ( 108 ) adapted for modulating the output of electrical power for driving the ultrasound transducer such that via ultrasonic heating by the ultrasound transducer: a. the first temperature measurement is maintained above a first predetermined threshold, b. the first temperature measurement is maintained below a second predetermined threshold, and c. the second temperature measurement is maintained below a third predetermined threshold; and wherein the first predetermined threshold is above the third predetermined threshold.

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09-08-2012 дата публикации

Systems, assemblies, and methods for treating a bronchial tree

Номер: US20120203216A1
Принадлежит: Innovative Pulmonary Solutions Inc

Systems, assemblies, and methods to treat pulmonary diseases are used to decrease nervous system input to distal regions of the bronchial tree within the lungs. Treatment systems damage nerve tissue to temporarily or permanently decrease nervous system input. The treatment systems are capable of heating nerve tissue, cooling the nerve tissue, delivering a flowable substance that cause trauma to the nerve tissue, puncturing the nerve tissue, tearing the nerve tissue, cutting the nerve tissue, applying pressure to the nerve tissue, applying ultrasound to the nerve tissue, applying ionizing radiation to the nerve tissue, disrupting cell membranes of nerve tissue with electrical energy, or delivering long acting nerve blocking chemicals to the nerve tissue.

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23-08-2012 дата публикации

Medical device

Номер: US20120215136A1
Принадлежит: Smith and Nephew Inc

A modular medical device includes a core module housing. The core module housing includes a treatment module interface configured to couple to any one of a plurality of treatment modules, and each of the plurality of treatment modules includes a treatment assembly configured to apply a medical treatment. The core housing module contains one or more processing devices coupled to the treatment module interface and configured to determine which particular treatment module, from the plurality of treatment modules, is coupled to the treatment module interface. The one or more processing devices are configured to select, based on the determination, a set of control instructions for the particular treatment module from a plurality of control instructions, and control the particular treatment module using the selected control instructions such that the treatment assembly of the particular treatment module applies the medical treatment for which the treatment assembly is configured.

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23-08-2012 дата публикации

Device, Methods, and Control for Sonic Guidance of Molecules and Other Material Utilizing Time-Reversal Acoustics

Номер: US20120215157A1
Принадлежит: UNIVERSITY OF CALIFORNIA

The present invention provides for a method of controlling mass movement of fluid material within a field of interest comprising using time reversal acoustic focusing. The time reversal acoustic focusing can be is used for simultaneous spatial and temporal focusing of acoustic energy to control the duration of localization and/or direction of movement of material within tissue or liquid within tissue. Both delivery of material and persistence with respect to target locations can be enhanced by focusing of sonic waveforms or transmissions towards targeted areas in a field of interest, such as within a patient.

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30-08-2012 дата публикации

Methods and protocols for providing artificially induced vibrations (aivs) to mammalian patients for therapeutic purposes

Номер: US20120220905A1
Автор: Yuval Avni
Принадлежит: ADS and B INVESTMENT FUND LP

The present invention discloses a method of producing therapeutic oscillations useful in treating a mammalian patient comprising steps of: obtaining an artificially induced vibrations device (AIVD) useful for a patients wellness for producing artificially induced vibrations of any of a given frequency, pressure, amplitude, volume and duration according to a protocol; said AIVD comprising: a. plurality of regulators, each of which is adapted to define an AIVD; b. mechanism for producing the protocol of said defined individual AIVs; and, c. effector adapted to introduce said protocol of produced AIVs to impinge in or on at least at least one body portion of a patient; wherein said therapeutic protocol of AIVs comprises two or more different individual time resolved AIVs.

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13-09-2012 дата публикации

System and method for renal artery occlusion during renal denervation therapy

Номер: US20120232409A1
Принадлежит: Boston Scientific Scimed Inc

A catheter includes a flexible shaft having a length sufficient to access a patient's renal artery relative to a percutaneous access location. A treatment arrangement is provided at a distal end of the shaft and configured for deployment in the renal artery. The treatment arrangement includes an ablation arrangement configured to deliver renal denervation therapy. An occlusion arrangement is configured for deployment in the renal artery and for altering blood flow through the renal artery during or subsequent to renal denervation therapy delivery. A monitoring unit is configured for monitoring for a change in one or more physiologic parameters influenced by the renal denervation therapy. The monitoring unit is configured to produce data useful in assessing effectiveness of the renal denervation therapy based on the physiologic parameter monitoring.

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20-09-2012 дата публикации

Nerve treatment system

Номер: US20120238919A1
Автор: Michael Gertner
Принадлежит: Kona Medical Inc

In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.

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04-10-2012 дата публикации

Ultrasonic probe and ultrasonic probe manufacturing method

Номер: US20120253199A1
Автор: Minoru Aoki
Принадлежит: Toshiba Corp, Toshiba Medical Systems Corp

According to one embodiment, an ultrasonic probe includes a transducer element, a backing material, and a buffer layer. The transducer element vibrates to transmit and receive an ultrasonic wave. The buffer layer is provided on the back side of the transducer element. The backing material is provided on the back side of the buffer layer and damps an ultrasonic wave from the transducer element. The buffer layer has a Poisson ratio larger than that of the backing material.

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11-10-2012 дата публикации

Apparatus and methods to create and maintain an intra-atrial pressure relief opening

Номер: US20120259263A1
Принадлежит: DC Devices Inc

The present disclosure relates to a method and a device for treating heart failure by normalizing elevated blood pressure in the left and right atria of a heart of a mammal The present disclosure includes methods for creating and maintaining an opening in the atrial septum. Tools for making an opening and enlarging the opening are also disclosed. Use of the techniques and tools described herein prolongs the patency of an intra-atrial pressure relief opening.

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25-10-2012 дата публикации

Energetic modulation of nerves

Номер: US20120271171A1
Автор: Michael Gertner
Принадлежит: Kona Medical Inc

A system to modulate an autonomic nerve in a patient utilizing transcutaneous ultrasound energy delivery includes a processor comprising an input for receiving information regarding energy and power to be delivered to a treatment region containing the nerve, and an output for outputting a signal, wherein the processor is configured to determine a position of a reference target from outside the patient to localize the nerve relative to the reference target, a therapeutic energy device comprising a transducer for delivering ultrasound energy from outside the patient, a controller to control an aiming of the transducer based at least in part on the signal from the processor, and an imaging system coupled to the processor or the therapeutic energy device.

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25-10-2012 дата публикации

Apparatus and Method for Ablating Tissue

Номер: US20120271334A1
Принадлежит: Individual

A control system alters one or more characteristics of an ablating element to ablate tissue. In one aspect, the control system delivers energy nearer to the surface of the tissue by changing the frequency or power. In another aspect, the ablating element delivers focused ultrasound which is focused in at least one dimension. The ablating device may also have a number of ablating elements with different characteristics such as focal length.

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01-11-2012 дата публикации

Method and apparatus for real time monitoring of tissue layers

Номер: US20120277587A1
Принадлежит: SYNERON MEDICAL LTD

The disclosed method and apparatus employ ultrasound beams to monitor the tissue type composition of body tissue that is to be treated and the temperature at each body tissue type or layer in real time. Additionally, the disclosed method and apparatus also provides ultrasound-based thermo-control of an aesthetic body treatment session.

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01-11-2012 дата публикации

Dissection handpiece and method for reducing the appearance of cellulite

Номер: US20120277674A1
Принадлежит: Cabochon Aesthetics Inc

A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

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08-11-2012 дата публикации

Photonic and Thermal Kinetic Energy Therapeutic Device, System and Method

Номер: US20120283603A1
Принадлежит: Shapiro Ronald S, Sutton David B

An apparatus includes a housing having a treatment surface, a light source disposed adjacent the treatment surface and configured to emit dynamic photonic energy, a thermal element disposed adjacent the treatment surface and configured to emit dynamic thermal kinetic energy, and a controller disposed in the housing, the controller in communication with the light source and the thermal element to vary a plurality of parameters of the light source and the thermal element to control the characteristics of the dynamic photonic energy and the dynamic thermal kinetic energy emitted thereby. The treatment surface can also house a variety of sensors that can capture a variety of physical and chemical data, which is integrated with a malleable energy composition and delivery system that co-ordinates with the treatment progress.

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15-11-2012 дата публикации

Ultrasound probe

Номер: US20120285250A1
Принадлежит: Humanscan Co Ltd

The present invention relates to an ultrasound therapy system using high-intensity focused ultrasound. The ultrasound therapy improves ultrasound and heat release characteristics and provides an ultrasound probe which easily performs manufacturing and maintenance processes. According to the present invention, a housing is recessed on the inward side around the upper-part edge. A plurality of mounting holes is uniformly formed from the outside at a constant radius to the edge in the center of the upper part. A plurality of probe units is respectively installed in the plurality of mounting holes to form a sphere on the upper part of the housing. And a grounding film covers the sphere which the plurality of probe units forms.

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15-11-2012 дата публикации

Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject

Номер: US20120289761A1
Принадлежит: SEARETE LLC

Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more cooling elements is configured to be implantable, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.

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15-11-2012 дата публикации

Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject

Номер: US20120289763A1
Принадлежит: SEARETE LLC

Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more passive cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more passive cooling elements is configured to be implantable, and wherein the one or more passive cooling elements includes a first portion configured to be in association with the one or more tissues to be cooled, and a second portion configured to be placed in association with one or more tissues adjacent to an external epidermal tissue of the vertebrate subject.

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22-11-2012 дата публикации

Energy facilitated composition delivery

Номер: US20120296262A1
Автор: Osamu Katoh, Wayne Ogata
Принадлежит: RetroVascular Inc

A device for delivering a composition to a hollow body region is disclosed. In one aspect, the device comprises a first longitudinal member and a second longitudinal member. Both of the longitudinal members may comprise conductive electrodes. The longitudinal members are further configured to be connected to an energy source such that the conductive electrodes are configured to generate an energy field. At least one of the longitudinal members further comprises a delivery element configured to deliver at least one composition to the body region, such that the composition is delivered in a direction that is influenced by the generated energy field. In one aspect, the body region is a vessel comprising an occlusion.

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29-11-2012 дата публикации

Method and system for treatment and diagnosis using ultrasound

Номер: US20120302883A1
Принадлежит: SAMSUNG ELECTRONICS CO LTD

A method and system for treatment and diagnosis using ultrasound includes irradiating ultrasound for treatment into a treatment site, inducing a shear wave around the treatment site, irradiating ultrasound for diagnosis into the treatment site, and determining a degree of treatment or necrosis of a tissue of the treatment site by using a measured displacement of the shear wave.

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13-12-2012 дата публикации

Image guided high intensity focused ultrasound treatment of nerves

Номер: US20120316426A1
Принадлежит: UNIVERSITY OF WASHINGTON

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

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03-01-2013 дата публикации

Low-profile ultrasound transducer

Номер: US20130006153A1
Автор: George K. Lewis, Jr.
Принадлежит: ZETROZ LLC

The present invention relates to a low-profile ultrasound transducer. The low-profile ultrasound transducer includes a piezoelectric component operative to receive a driving signal from an energy generating module and to emit the driving signal as ultrasonic energy. The piezoelectric component has a front surface and a back surface, and the energy generating module includes a plurality of electronic components. The low-profile ultrasound transducer also includes a lens component directly or indirectly deposited on the front surface of the piezoelectric component. The lens component includes a lens portion and a support portion. The lens portion of the lens component is configured to control the direction and wave pattern of the ultrasonic energy emitted from the piezoelectric component. The support portion of the lens component is configured to hold the piezoelectric component in place and to provide a chamber for housing at least one electronic component of the energy generating module. Methods of use and related devices are also disclosed.

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10-01-2013 дата публикации

Methods and systems for ultrasound treatment

Номер: US20130012842A1
Автор: Peter G. Barthe
Принадлежит: Guided Therapy Systems LLC

A method and system for ultrasound treatment are provided. Acoustic energy, including ultrasound, can serve as input energy to a mask with apertures, such apertures acting as secondary acoustic sources to create a modulated output acoustic energy in a treatment region and treatment effects. Under proper control output energy can be precisely placed and controlled in tissue. In some embodiments, methods and systems are configured for ultrasound treatment based on creating an output energy distribution in tissue. In some embodiments, methods and systems are configured based on creating an output temperature distribution in tissue.

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10-01-2013 дата публикации

Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen

Номер: US20130012867A1
Принадлежит: Ardian Inc

Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.

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24-01-2013 дата публикации

Ultrasonic transducer

Номер: US20130023801A1
Принадлежит: Chongqing Haifu Hifu Technology Co Ltd

An ultrasonic transducer is disclosed, which includes one or a plurality of ultrasonic emitting units. Wavefronts of the ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are sphere surfaces with uniform radius, and the one or the plurality of ultrasonic emitting units can reflect ultrasound. The one ultrasonic emitting unit is configured to form a spherical resonant cavity, or the plurality of ultrasonic emitting units are configured to form a spherical resonant cavity collectively. An internal cavity of the spherical resonant cavity has a spherical shell shape or a cross-sectional spherical shell shape with a spherical center therein. The ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are focused on an area in which the spherical center of the spherical resonant cavity is located. The ultrasonic transducer not only can be provided with a large ultrasonic emitting area and a great focusing gain that render the energy of the ultrasonic focus enhanced dramatically, but also can be free from the influence of work frequency of an ultrasonic source.

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07-02-2013 дата публикации

Robotic systems and methods for treating tissue

Номер: US20130035537A1
Принадлежит: Hansen Medical Inc

A method of manipulating an elongate member in at least two degrees of freedom includes holding an elongate member between two rotary members that define respective rotational axes, the elongate member having a flexible proximal portion, a distal rigid needle attached to the proximal portion, and an operative element for delivering energy, the needle having a distal port, actuating at least one of the rotary members in a rotational direction about its rotational axis to generate a corresponding linear motion of the elongate member along a longitudinal axis of the elongate member, and actuating at least one of the rotary members in a linear direction along its rotational axis to generate a corresponding rotational motion of the elongate member about the longitudinal axis of the elongate member.

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14-02-2013 дата публикации

Lesion generation through bone using histotripsy therapy without aberration correction

Номер: US20130041293A1
Автор: Charles A. Cain
Принадлежит: University of Michigan

A medical imaging and therapy device is provided that may include any of a number of features. The device may include a Histotripsy transducer, a generator and controller configured to deliver Histotripsy energy from the transducer to target tissue, and an imaging system. In some embodiments, a method of treating tissue with Histotripsy energy comprises positioning a focus of a histotripsy transducer on a target tissue, delivering histotripsy energy from the histotripsy transducer through a bone aberrator, forming a histotripsy bubble cloud on the focus, and preventing the formation of secondary histotripsy bubble clouds without implementing an aberration correction algorithm.

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21-02-2013 дата публикации

Apparatuses and systems for generating high-frequency shockwaves, and methods of use

Номер: US20130046207A1
Принадлежит: University of Texas System

Apparatuses and methods for generating therapeutic shock waves. Some embodiments comprise: an acoustic-wave generator configured to emit acoustic waves having at least one frequency between 1 MHz and 1000 MHz; a shock wave housing coupled to the acoustic-wave generator; and a shock wave medium disposed in the shock wave housing; where the apparatus is configured such that if the acoustic-wave generator emits acoustic waves then at least some portion of the acoustic waves will travel through the shock wave medium and form one or more shock waves.

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07-03-2013 дата публикации

Dual-Mode Piezocomposite Ultrasonic Transducer

Номер: US20130060140A1
Автор: Yegor Sinelnikov
Принадлежит: Individual

A compact, high power, dual mode, emitting and receiving ultrasound transducer and method for applying ultrasonic energy within a living subject and for monitoring the effects it induces in tissue comprises a set of piezoelectric polymeric transducer elements and a set of piezoelectric ceramic elements, bonded together. The polymeric transducer elements have electrodes enabling their use for low power diagnostic imaging interrogation of the tissue and the ceramic transducer elements have electrodes enabling their use for high power therapy applications.

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07-03-2013 дата публикации

Medical apparatus and method of controlling thereof

Номер: US20130060170A1
Принадлежит: SAMSUNG ELECTRONICS CO LTD

A medical apparatus and a method of controlling thereof are provided. The medical apparatus includes an ultrasound transducer unit including a plurality of ultrasound transducer elements, the ultrasound transducer elements being configured to transform signals into ultrasound and output the transformed ultrasound, a grouping unit configured to group the ultrasound transducer elements into a plurality of groups, and a signal generating unit configured to generate the signals to be transformed into the ultrasound and output the generated signals to the groups via a plurality of output channels respectively corresponding to the groups.

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14-03-2013 дата публикации

METHOD AND COMPOSITION FOR HYPERTHERMALLY TREATING CELLS

Номер: US20130066190A1
Автор: PEYMAN Gholam A.
Принадлежит:

A method and composition for hyperthermally treating tumor cells in a patient under conditions that affect tumor stem cells and tumor cells. In one embodiment, the method is administered in combination with localized internal ionizing radiation therapy. 1. A method of simultaneously providing localized internal ionizing radiation therapy in combination with thermal therapy to a target site in a patient in need thereof , the method comprisingadministering to the patient a composition of nanoparticles, the nanoparticles containing at least one radioactive isotope and coated with anti-tumor antibodies, the radioactive nanoparticle resulting in radiation therapy at a dose sufficient to damage tumor-associated vessels at the localized target site, andadministering localized thermal therapy at the target site essentially simultaneously during the radiation therapy.3. The method of where the target is a tumor site.4. The method of where the target is neovascularization tissue.5. The method of where the target is endothelial cells in new blood vessels in a patient with exudative age related macular degeneration.6. The method of wherein the radioactive nanoparticle is a magnetic claim 1 , diamagnetic claim 1 , ferromagnetic claim 1 , non-ferromagnetic and/or paramagnetic nanoparticle.7. The method of wherein the antitumor antibody is coated on or conjugated with the radioactive nanoparticle.8. The method of wherein the composition is administered intravenously.9. The method of wherein the radioactive isotope is an α-emitting isotope claim 1 , a β-emitting isotope claim 1 , or a combination thereof.10. The method of wherein the isotope is selected from the group consisting of AtAc claim 9 , Bi claim 9 , Bi claim 9 , Ra claim 9 , Pb claim 9 , Tb claim 9 , I claim 9 , cu claim 9 , I claim 9 , Bi claim 9 , and Bi11. The method of wherein the dose of the isotope ranges from 10 μCi to 20 claim 9 ,000 μCi.12. The method of wherein thermal therapy is applied with a controlled energy ...

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14-03-2013 дата публикации

High-frequency operation apparatus and operation apparatus

Номер: US20130066238A1
Принадлежит: OLYMPUS MEDICAL SYSTEMS CORP

A high-frequency operation apparatus includes a grasping portion for grasping a treatment target living tissue, an electrode for supplying a high-frequency current to the living tissue, a high-frequency current supplying section that generates the high-frequency current necessary for treatment, a cable section that transmits the high-frequency current, an impedance measuring section for measuring an impedance value of the living tissue, a detecting section that detects that the impedance value reaches an impedance threshold at a time when moisture in the living tissue starts to evaporate, a measuring section that measures an output time of the high-frequency current after the detection, a storing section that stores a set time, and an output control section that performs control for stopping an output when the output time of the high-frequency current reaches the stored set time.

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14-03-2013 дата публикации

ULTRASOUND NEUROMODULATION OF THE BRAIN, NERVE ROOTS, AND PERIPHERAL NERVES

Номер: US20130066239A1
Автор: Mishelevich David J.
Принадлежит:

Disclosed are methods and systems for non-invasive ultrasound neuromodulation of superficial cortex of the brain or stimulation of nerve roots or peripheral nerves. Such stimulation is used for such purposes as determination of motor threshold, demonstrating whether connectivity to peripheral nerves or motor neurons exists and performing nerve conduction-speed studies. Neuromodulation of the brain allows treatment of conditions such as depression via stimulating superficial neural structures that have connections to deeper involved centers. Imaging is optional. 1. A system of non-invasively neuromodulating the brain using ultrasound stimulation , the system comprising:aiming an ultrasound transducer at superficial cortex,applying pulsed power to said ultrasound transducer via a control circuit thereby neuromodulating the target,whereby results are selected from the group consisting of functional and diagnostic.2. The system of claim 1 , wherein the plurality of control elements is selected from the group consisting of intensity claim 1 , frequency claim 1 , pulse duration claim 1 , and firing pattern.3. The system of claim 1 , wherein the mechanism for focus of the ultrasound is selected from the group of fixed ultrasound array claim 1 , flat ultrasound array with lens claim 1 , non-flat ultrasound array with lens claim 1 , flat ultrasound array with controlled phase and intensity relationships claim 1 , and ultrasound non-flat array with controlled phase and intensity relationships.4. The system of wherein the level ultrasound stimulation is used to assess the excitability of the cortex.5. A system of non-invasively neuromodulating the brain using ultrasound stimulation claim 1 , the system comprising:aiming an ultrasound transducer at a neural target,applying pulsed power to said ultrasound transducer via a control circuit thereby stimulating the target,placement of one or a plurality of sensors at a distance from the target, whereby results are selected from the ...

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14-03-2013 дата публикации

ULTRASOUND TRANSDUCER FOR SELECTIVELY GENERATING ULTRASOUND WAVES AND HEAT

Номер: US20130066240A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

In order to provide heating means for an ultrasonic application setup, adapted for heating a sample () gently and fast and saving costs and space, an ultrasound transducer () capable of being driven at multiple frequencies including a main frequency for efficient production of ultrasound waves and at least one alternative frequency, at which almost no ultrasound is generated, a system for sample analysis comprising such an ultrasound transducer () and a method for controlling such an ultrasound transducer () are proposed, wherein the ultrasound transducer () is driven either at the main frequency for generating ultrasonic waves or at the alternative frequency for generating heat in the ultrasound transducer (), if the sample () is to be heated. 1. A method of operating an ultrasound transducer or for sample analysis , comprising:{'b': 10', '10, 'controlling the ultrasound transducer () that is capable of being operated at at least two frequencies including a main frequency and at least one alternative frequency, wherein the ultrasound transducer () is operated'}{'b': '20', 'at the main frequency for generating ultrasound waves, if ultrasound waves are to be coupled into the sample (); and'}{'b': 10', '20, 'at one of the alternative frequencies for generating heat in the ultrasound transducer (), if the sample () is to be heated.'}210. The method of claim 1 , wherein the main frequency and the alternative frequency are resonance frequencies of the ultrasound transducer ().31010. The method of claim 1 , wherein when driving the ultrasound transducer () at at least one of the alternative frequencies claim 1 , less ultrasound intensity is generated than when driving the ultrasound transducer () at the main frequency.41020. The method according to claim 1 , wherein the ultrasound intensity generated when driving the ultrasound transducer () at at least one of the alternative frequencies is not sufficient for generating cavitations in the sample ().520. The method ...

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21-03-2013 дата публикации

APPARATUS AND METHODS FOR THE DESTRUCTION OF ADIPOSE TISSUE

Номер: US20130072825A1
Принадлежит: LIPOSONIX, INC.

Methods and apparatus are described for modifying unwanted tissue for cosmetic reasons. The methods provide a non-invasive manner to perform body contouring by destroying adipose tissue while simultaneously causing collagen contraction in a single procedure so that as destroyed tissue is removed from a treatment volume, the volume shrinks gradually to maintain the skin tone of the treatment area. The procedure may involve multiple treatments to the same treatment area or location. 1. A method of modifying adipose tissue using high intensity focused ultrasound energy , the method comprising:determining a volume of adipose tissue to be treated;identifying a corresponding surface area of skin over the volume of adipose tissue;moving a therapy transducer on the surface area of skin; and{'sup': '2', 'applying multiple treatments of the high intensity focused ultrasound energy with an energy flux less than 35 J/cminto a targeted volume of the volume of adipose tissue.'}2. The method of further comprising:marking the corresponding surface area of skin to create a plurality of guide markers at a predetermined spacing within the corresponding surface area.3. The method of wherein a temperature of the adipose tissue in the targeted volume is less than 37 degrees Celsius between consecutive treatments of the multiple treatments and is greater than 37 degrees Celsius after the multiple treatments are applied.4. The method of further comprising:during the application of the multiple treatments, reducing a velocity at which the therapy transducer is moving.5. The method of wherein the adipose tissue in the targeted volume includes a lesion field at the focal zone of the therapy transducer and a halo field surrounding the lesion field claim 4 , and applying the multiple treatments of the high intensity focused ultrasound energy further comprises:increasing a size of the halo field from the reduction in the velocity at which the therapy transducer is moving.6. The method of further ...

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21-03-2013 дата публикации

Ultrasound treatment of sub-dermal tissue for cosmetic effects

Номер: US20130072826A1
Принадлежит: Guided Therapy Systems LLC

A method and system for noninvasive face lifts and tissue tightening are disclosed. The method and treatment system are configured for thermal treatment of Superficial Muscular Aponeurosis System (SMAS) tissue, muscular fascia, or both. In one embodiment, a cosmetic system is configured for treating the SMAS and/or muscular fasica through delivery of ultrasound energy at a depth, distribution, timing, and energy level to achieve the desired therapeutic effect.

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28-03-2013 дата публикации

METHOD AND SYSTEM OF OPERATING A MULTI FOCUSED ACOUSTIC WAVE SOURCE

Номер: US20130079621A1

A method of operating a multi focused acoustic wave source. The method comprises providing the multi focused acoustic wave source, providing a plurality of target acoustic pressures to be applied on a plurality of regions of interest (ROIs) in at least one cellular tissue, computing a transmission pattern of multi-focal acoustic energy according to the plurality of target acoustic pressures, and operating the multi focused acoustic wave source according to the transmission pattern. 1. A method of operating a multi focused acoustic wave source , comprising:providing a multi focused acoustic wave source having a plurality of acoustic energy elements;providing a multi-focal stimulation pattern that defines a plurality of target acoustic pressures to be applied in a plurality of focuses in a target area in at least one cellular tissue;computing a spatially non segmented transmission pattern which defines at least one transmission characteristic of each one of a plurality of acoustic energy elements according to said multi-focal stimulation pattern; andoperating said plurality of acoustic energy elements according to said spatially non segmented transmission pattern to apply said plurality of target acoustic pressures on said target area, each of said plurality of acoustic energy elements transmits an acoustic energy to a several of said plurality of focuses.2. The method of claim 1 , wherein said spatially non segmented transmission pattern is transmitted with energy in frequencies at the range between 1 Mega Hertz (MHz) and 20 MHz.3. The method of claim 1 , wherein said spatially non segmented transmission pattern is transmitted with energy having a pulse average acoustic intensity of up to 100 W/cm̂2.4. The method of claim 1 , wherein said at least one cellular tissue is a retina of the eye.5. The method of claim 1 , wherein each said target acoustic pressure is different from another said target acoustic pressures.6. The method of claim 1 , wherein said providing ...

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28-03-2013 дата публикации

ULTRASOUND-NEUROMODULATION TECHNIQUES FOR CONTROL OF PERMEABILITY OF THE BLOOD-BRAIN BARRIER

Номер: US20130079682A1
Автор: Mischelevich David J.
Принадлежит:

Disclosed are methods and systems and methods employing non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier. For example, such an alteration can permit increased penetration of a medication to increase its therapeutic effect. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency (carrier and/or neuromodulation frequency), pulse duration, firing pattern, and phase/intensity relationships for beam steering and focusing on targets and accomplishing up-regulation and/or down-regulation. 1. A method for altering a permeability of a blood-brain barrier in a patient , the method comprising:aiming at least one ultrasound transducer at least one target in a brain or a spinal cord of a human or animal, andenergizing at least one transducer to deliver pulsed ultrasound energy to the at least one target,wherein permeability of the blood-brain barrier in the vicinity of the target is altered.2. The method of wherein the transducer is controlled to deliver ultrasound pulsed power that increases the permeability of the blood-brain barrier.3. The method of further comprising administering a drug to the patient wherein the effectiveness of the drug is enhanced by increased penetration of that drug into the target because of the increase in permeability of the blood-brain barrier.4. The method of wherein the transducer is controlled to deliver ultrasound pulsed power which decreases the permeability of the blood-brain barrier.5. The method of further comprising administering a drug to the patient wherein the side effects of the drug are reduced due to decreased penetration of the drug into the target because of the decrease in permeability of the blood-brain barrier.6. The method of wherein a target is selected to have permeability to a drug increased ...

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11-04-2013 дата публикации

Device and methods for renal nerve modulation

Номер: US20130090578A1
Принадлежит: Boston Scientific Scimed Inc

Systems for nerve modulation are disclosed. An example system may include a first elongate element having a distal end and a proximal end and having at least one transducer disposed adjacent the distal end. The transducer may be an ultrasound transducer. Activation of the transducer may radiate acoustic energy from in two directions simultaneously.

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11-04-2013 дата публикации

Pulsed Cavitational Therapeutic Ultrasound With Dithering

Номер: US20130090579A1
Принадлежит:

Cavitation memory effects occur when remnants of cavitation bubbles (nuclei) persist in the host medium and act as seeds for subsequent events. In pulsed cavitational ultrasound therapy, or histotripsy, this effect may cause cavitation to repeatedly occur at these seeded locations within a target volume, producing inhomogeneous tissue fractionation or requiring an excess number of pulses to completely homogenize the target volume. Cavitation memory can be removed with a dithering technique. The spatial-temporal memory effect of micro-bubbles can be defeated by (1) passive temporal dithering, (2) active dithering, or (3) use of therapy pulses above the de novo threshold. 1. A method of performing histotripsy therapy , comprising;delivering at least one histotripsy therapy pulse to a volume of human tissue to generate acoustic cavitation in the volume of tissue;defeating a spatial-temporal memory effect generated by the acoustic cavitation with a dithering technique; andapplying at least one additional histotripsy therapy pulse to form a homogeneous lesion in the volume of human tissue.2. The method of wherein the delivering at least one histotripsy therapy pulse step comprises delivering at least one ultrasound pulse having a peak negative pressure >10 MPa claim 1 , a duration <50 μs claim 1 , and a duty cycle <1%.3. The method of wherein the dithering technique comprises passive temporal dithering.4. The method of wherein passive temporal dithering comprises limiting a pulse repetition frequency of the histotripsy therapy pulse.5. The method of wherein passive temporal dithering comprises waiting for remnant micronuclei to disappear before initiating another histotripsy therapy pulse.6. The method of wherein the waiting step comprises waiting for a period of approximately 1 ms to approximately 10 ms.7. The method of wherein the dithering technique comprises active dithering.8. The method of wherein active dithering comprises applying highly localized histotripsy ...

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18-04-2013 дата публикации

METHOD FOR USING HIGH INTENSITY FOCUSED ULTRASOUND AND ASSOCIATED SYSTEMS AND DEVICES

Номер: US20130096431A1
Принадлежит: UNIVERSITY OF WASHINGTON

A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface. 1. A probe for administering ultrasound therapy to a treatment site within a patient's body , wherein a tissue mass is disposed between the probe and the treatment site , comprising:(a) an elongate supporting structure having a distal end and a proximal end, said elongate supporting structure including a section at its proximal end that is adapted to be grasped and manipulated by a clinician to at least initially position the distal end of the elongate supporting structure at a desired location generally adjacent to the tissue mass;(b) a high intensity focused ultrasound (HIFU) transducer disposed at the distal end of the elongate supporting structure, said HIFU transducer having an aperture through which HIFU waves are transmitted, said aperture being of a sufficient size to transmit therapeutic HIFU waves, so that the therapeutic HIFU waves have sufficient intensity remaining upon reaching the treatment site after being attenuated by their passage through the tissue mass, to achieve a desired therapeutic effect, without ...

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18-04-2013 дата публикации

SYSTEMS AND METHODS FOR TREATING INJURIES TO JOINTS AND CONNECTIVE TISSUE

Номер: US20130096471A1
Принадлежит: GUIDED THERAPY SYSTEMS, LLC

According to various embodiments, methods and systems useful for treating injuries to joints are provided herein. In some embodiments, methods and systems useful for permanent relief of pain in joints are provided herein. Various embodiments provide for combining therapeutic ultrasound energy directed to a joint with a medicant injected into the joint. 1. A method of treating an injury in a joint , the method comprising:targeting injured fibrous soft tissue located in at least one of at and proximate to an injury location comprising a portion of a joint;directing therapeutic ultrasound energy to the injured fibrous soft tissue;creating a conformal region of elevated temperature in the injured fibrous soft tissue; andcreating at least one thermally induced biological effect in the injured fibrous soft tissue.2. The method according to claim 1 , wherein the thermally induced biological effect is at least one of coagulation claim 1 , increased perfusion claim 1 , reduction of inflammation claim 1 , generation of heat shock proteins claim 1 , and initiation of healing cascade.3. The method according to claim 1 , further comprising targeting a capsule in the portion of the joint; and treating inflamed tissue at or proximate to the capsule.4. The method according to claim 1 , further comprising driving a medicant into the injured soft fibrous tissue.5. The method according to claim 4 , further comprising activating the medicant with the therapeutic ultrasound energy claim 4 , wherein the medicant is a steroid.6. The method according to claim 1 , further comprising peaking inflammation in the injury location and initiating a coagulation cascade in at least a portion of the joint.7. The method according to claim 1 , further comprising welding a portion of the injured fibrous soft tissue with the conformal ultrasound energy and repairing a tear in the portion of the joint.8. The method according to claim 1 , further comprising stimulating collagen growth in a portion of the ...

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18-04-2013 дата публикации

METHODS FOR USING ULTRASOUND FOR ENHANCING EFFICIENCY AND TARGETING OF INTRANASAL ADMINISTRATION OF THERAPEUTIC COMPOUNDS TO THE CENTRAL NERVOUS SYSTEM

Номер: US20130096488A1
Автор: Frey, II William H.
Принадлежит: HealthPartners Research & Education

The present invention is directed to methods for reducing systemic absorption of therapeutic compounds or agents while enhancing efficiency of delivery and targeting of intranasal administration of such compounds or agents to the central nervous system. More specifically, use of ultrasound technology in conjunction with intranasal delivery of a therapeutic compound, or pharmaceutical composition, wherein the intranasal delivery is preferably to the upper one third of a patient's nasal cavity, thereby reducing therapeutic compound or agent absorption into the blood. At the same time, the present invention results in reducing the delivery of therapeutic compounds and/or agents to the peripheral tissues, increases therapeutic delivery of the compounds and/or agents to the central nervous system generally, and increases targeting of the therapeutics and/or agents to specific target regions within the central nervous system. 1. A method for transporting an effective dose comprising at least one therapeutic agent and/or compound to a damaged or degenerating or injured central nervous system of a mammal , wherein the damage or degeneration or injury is caused by a neurological disease or condition or trauma within at least one region of the central nervous system , comprising:administering the effective dose to the nasal cavity of the mammal;enabling at least some of the effective dose comprising at least one therapeutic agent and/or compound of the effective dose to directly access the damaged or degenerating or injured central nervous system by bypassing the blood-brain barrier of the mammal, wherein at least a portion of the at least one therapeutic agent and/or compound of the effective dose enters the mammal's bloodstream and/or the perivascular spaces of blood vessels of the mammal's cerebrovasculature;allowing a time period to pass;after passage of the time period, focusing ultrasound energy on at least one selected target region corresponding to the at least one ...

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18-04-2013 дата публикации

METHOD FOR ABLATING BODY TISSUE

Номер: US20130096592A1
Принадлежит: VytronUS, Inc.

A tissue ablation system for treating fibrillation in a patient comprises a steerable interventional catheter having an energy source that emits a beam of energy to ablate tissue thereby creating a conduction block for aberrant electrical pathways. The system also includes a handle disposed near a proximal end of the interventional catheter and has an actuation mechanism for steering the interventional catheter. A console allows the system to be controlled and provides power to the system, and a display pod is electrically coupled with the console. The display pod has a display panel to display system information to a user and allows the user to control the system. A catheter pod is releasably coupled with the handle electrically and mechanically, and also electrically coupled with the display pod. 1. A system for ablating tissue , said system comprising:an elongate flexible shaft having a proximal portion, a distal portion, and a rotation axis;an ultrasound transducer adjacent the distal end of the elongate flexible shaft, wherein the ultrasound transducer is configured to emit a beam of ultrasound energy; andwherein the beam of ultrasound energy is configured to ablate target tissue without contact between the ultrasound transducer and the target tissue, andwherein the beam of ultrasound energy forms a continuous lesion in the target tissue while the distal portion of the elongate flexible shaft is moving.2. The system of claim 1 , further comprising a sensor adjacent the ultrasound transducer claim 1 , the sensor adapted to sense distance between the ultrasound transducer and a surface of the target tissue or adapted to sense properties of the target tissue.3. The system of claim 2 , wherein the sensed properties comprise target tissue wall thickness claim 2 , lesion properties in the target tissue claim 2 , or other target tissue properties.4. The system of claim 2 , wherein the ultrasound transducer and the sensor are the same ultrasound transducer.5. The ...

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18-04-2013 дата публикации

SYSTEM AND METHOD FOR ENERGY DELIVERY TO TISSUE WHILE MONITORING POSITION, LESION DEPTH, AND WALL MOTION

Номер: US20130096593A1
Принадлежит: VytronUS, Inc.

Systems and methods for ablating tissue include an ablation device having an energy source and a sensor. The energy source provides a beam of energy directable to target tissue, and the sensor senses energy reflected back from the target tissue. The sensor collects various information from the target tissue in order to facilitate adjustment of ablation operating parameters, such as changing power or position of the energy beam. Gap distance between the energy source and target tissue, energy beam incident angle, tissue motion, tissue type, lesion depth, etc. are examples of some of the information that may be collected during the ablation process and used to help control ablation of the tissue. 1. A method for ablating tissue , said method comprising:providing an elongate shaft having an ultrasound transducer and a sensor adjacent a distal portion of the elongate shaft, the ultrasound transducer providing a beam of ultrasound energy;positioning the ultrasound transducer adjacent target tissue for treatment;sensing the target tissue with the sensor thereby determining characteristics of the target tissue;ablating the target tissue with the beam of ultrasound energy thereby forming a continuous lesion in the target tissue; andadjusting the ablating based on the sensed characteristics of the target tissue.2. The method of claim 1 , wherein the sensing is conducted before the ablating.3. The method of claim 1 , wherein the sensing is conducted while the ablating is performed.4. The method of claim 1 , wherein the adjusting comprises adjusting power of the beam of ultrasound.5. The method of claim 1 , wherein the adjusting comprises repositioning the ultrasound transducer relative to the target tissue.6. The method of claim 5 , wherein the repositioning comprises rotating or translating the ultrasound transducer relative to the target tissue.7. The method of claim 1 , wherein the sensor and the ultrasound transducer are the same ultrasound transducer.8. The method of ...

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18-04-2013 дата публикации

SYSTEM AND METHOD FOR DELIVERY OF ENERGY TO TISSUE WHILE COMPENSATING FOR COLLATERAL TISSUE

Номер: US20130096594A1
Принадлежит: VytronUS, Inc.

A tissue ablation method for treating atrial fibrillation in a patient comprises locating an ostium of a pulmonary vein and positioning an interventional catheter adjacent the ostium. The interventional catheter has an energy source. Collateral tissue adjacent the ostium is located and tissue around the ostium is ablated with energy from the energy source so as to form a contiguous lesion circumscribing the ostium. The lesion blocks aberrant electrical pathways in the tissue so as to reduce or eliminate the atrial fibrillation. The ablating is modified so as to avoid ablating or otherwise damaging the collateral tissue. 1. A method for ablating tissue , said method comprising:providing a catheter having an ultrasound transducer adjacent a distal end thereof and a sensor adjacent the ultrasound transducer;positioning the ultrasound transducer and the sensor adjacent target tissue;ablating the target tissue with a beam of ultrasound from the ultrasound transducer thereby forming a continuous lesion in the target tissue;sensing collateral tissue adjacent the target tissue with the sensor; andmodifying the ablating based on feedback from the sensing thereby avoiding or minimizing ablation of the collateral tissue.2. The method of claim 1 , wherein the ultrasound transducer and the sensor are the same ultrasound transducer.3. The method of claim 1 , wherein the positioning comprises positioning the catheter intravascularly.4. The method of claim 1 , wherein sensing the collateral tissue comprises identifying or characterizing properties of the collateral tissue.5. The method of claim 1 , wherein the sensing is performed before the ablating.6. The method of claim 1 , wherein the sensing is performed during the ablating.7. The method of claim 1 , wherein the modifying comprises modifying lesion path from an originally planned lesion path to a modified lesion path in order to avoid the collateral tissue.8. The method of claim 1 , wherein the modifying comprises adjusting ...

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18-04-2013 дата публикации

METHODS AND SYSTEMS FOR INDUCING HYPERTHERMIA

Номер: US20130096595A1
Принадлежит:

A system and methods are provided and thrombi treatments in which hyperthermia is induced in an initial phase and cavitation and/or drug release are induced in a subsequent phase in a region of interest in a human or animal body. The system includes an energy transmitter having a variable intensity and/or a variable frequency; and a control unit arranged to control the energy transmitter to operate in at least two different modes. In one embodiment, the first mode is a mode of operation having a mechanical index below a threshold level for cavitation; and the second mode is a mode of operation having a mechanical index above a threshold level for cavitation. In another embodiment, the first mode induces hyperthermia below a temperature threshold for releasing an encapsulated agent and the second mode induces hyperthermia above the temperature threshold. The initial hyperthermia treatment enhances the effect of subsequent treatments. 140.-. (canceled)41. A system for inducing hyperthermia and cavitation in a region of interest in a human or animal body comprising:an energy transmitter having a variable frequency; anda control unit arranged to control the energy transmitter to operate in at least two different modes,wherein a first mode is a mode of operation having a mechanical index below a threshold level for cavitation;wherein a second mode is a mode of operation having a mechanical index above a threshold level for cavitation,wherein the ultrasound transmitter is a single frequency band ultrasound transmitter, andwherein in the first mode of operation the ultrasound transmitter is arranged to operate at a high frequency above the centre frequency of the frequency band and wherein in the second mode of operation the ultrasound transmitter is arranged to operate at a low frequency below the centre frequency of the frequency band.42. A system as claimed in claim 41 , further comprising a monitoring unit arranged to monitor at least one parameter related to ...

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18-04-2013 дата публикации

REAL-TIME MONITORING AND CONTROL OF HIFU THERAPY IN MULTIPLE DIMENSIONS

Номер: US20130096597A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

Energy is transferred () to cause a mechanical property of biological tissue to change, as in ablation. An effect of the transferring is examined in more than one spatial dimension to, for example, make an ablation halting decision for a treatment region, i.e., line () or layer (), or for a location () within the region. Halting decisions can be based on lesion-central and/or lesion-peripheral longitudinal displacement of treated tissue evaluated in real time against a characteristic curve. Steering in the azimuthal and/or elevation direction is afforded by, for example, linear, or 2D, multi-channel ultrasound arrays for therapy and imaging. Protocols includable are region-wide scanning (SI ) and location-by-location completion for both (HIFU) therapy and tracking (acoustic-radiation-forced-based) displacement of treated tissue. Fine, location- to-location monitoring can be used for relatively inhomogeneous tissue; whereas, quicker, sparser and more generalized monitoring () can be employed for relatively homogeneous tissue. 1115110125130304844. A control device () for an ablation system that includes an ablation unit () , the ablation unit including a multi-element diagnostic array () placed confocally with a therapy array () that issues a therapy beam for transferring energy for changing a mechanical property () of biological tissue , said therapy beam having a most recent focus () , said control device comprising:{'b': '135', 'a combination multi-channel high power amplifier and matching network module ();'}{'b': '140', 'a triggering and control logic module (); and'}{'b': '145', 'a multi-channel ultrasound data acquisition and analysis module (),'}{'b': '140', 'wherein the triggering and control logic module () outputs triggering and control signals to synchronize timing and electronic steering of three types of acoustic beams, including therapy beams, push beams, and tracking beams, that are interspersed,'}{'b': 135', '140', '130', '830, 'further wherein the ...

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25-04-2013 дата публикации

METHODS DEVICES AND SYSTEMS OF PREPARING TARGETED MICROBUBBLE SHELLS

Номер: US20130101521A1
Принадлежит:

Targeted microbubbles are generated by post-labeling buried ligand microbubbles. According to embodiments, buried ligand microbubbles are created with steric brushes protecting functionalized polymer tethers. Ligands were attached to the functionalized tethers by diffusion of ligands of a small size through the steric barrier. The steric barrier was substantially capable of hindering access to the tethers by larger molecules. The embodiments disclosed include methods for creating microbubble batches that can be loaded with selected ligands, for titrating the targeting ligands thereby to reduce waste and cost, and for using resulting buried ligand molecules for medical purposes. 147-. (canceled)48. A method of making microbubbles , comprising:forming size-isolated microbubbles with a first attachment component, the forming including selecting microbubbles of a first size range from microbubbles spanning a second size range;storing the size-isolated microbubbles;recovering the stored size-isolated microbubbles and attaching a second attachment component to the size-isolated microbubbles.49. The method of claim 48 , wherein the forming includes generating a cake of microbubbles.50. The method of claim 49 , wherein the storing includes storing the cake of microbubbles.51. The method of claim 49 , wherein the attaching includes diluting the cake of microbubbles.52. The method of claim 48 , wherein the forming includes incorporating a shielding component in the microbubbles and the shielding and first attachment components include PEG chains.53. The method of claim 52 , wherein the attaching includes diffusing the second attachment component through a steric overbrush formed by the shielding component.54. The method of claim 48 , wherein the size-isolated microbubbles include a surface of amphiphilic phospholipids that are self-assembled in the forming to form a lipid monolayer shell.55. The method of claim 48 , further comprising using the size-isolated microbubbles as a ...

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25-04-2013 дата публикации

MODULATION AND ANALYSIS OF CEREBRAL PERFUSION IN EPILEPSY AND OTHER NEUROLOGICAL DISORDERS

Номер: US20130102833A1
Принадлежит: NEUROPACE, INC.

A system including an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required. 1. A method for responding to a neurological disorder in a human patient comprising:generating, by an implantable device, a signal representative of a cerebral perfusion measurement;receiving and processing, by the implantable device, at predetermined times, a cerebral perfusion measurement;automatically identifying, by the implantable device, a condition in the signal, wherein the condition comprises a predetermined change in cerebral perfusion;identifying, by the implantable device, a structure in a first hemisphere,monitoring, by the implantable device, the first hemisphere for increased blood flow; andautomatically performing an action, by the implantable device, wherein the action comprises generating an instruction for therapy based on the identified change in the cerebral perfusion, wherein the therapy comprises stimulating a neural structure in a second hemisphere that is contralateral to the first hemisphere.2. The method of claim 1 , wherein the therapy is intended to return the cerebral perfusion measurement to a desired value or range of values.3. The method of claim 1 , further comprising:continuously monitoring the signal; andidentifying, with an algorithm, a predetermined change in the cerebral perfusion, wherein the algorithm uses at least one of a control law or a threshold comparison to determine whether to cause an instruction to provide responsive therapy.4. The method of claim 1 , wherein the therapy is adapted to modulate the cerebral perfusion by modulating at least one of electrical activity or chemical ...

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25-04-2013 дата публикации

Imaging Feedback of Histotripsy Treatments with Ultrasound Transient Elastography

Номер: US20130102932A1
Принадлежит:

Methods and devices for imaging tissue elasticity change as a tool to provide feedback for histotripsy treatments. Tissue lesion elasticity was measured with ultrasound shear wave elastography, where a quasi-planar shear wave was induced by acoustic radiation force generated by the therapeutic array, and tracked with ultrasound imaging at 3000 frames per second. Based on the shear wave velocity calculated from the sequentially captured frames, the Young's modulus in the lesion area was reconstructed. Results showed that the lesions were clearly identified on the elasticity images as an area with decreased elasticity. Lesions produced by histotripsy can be detected with high sensitivity using shear wave elastography. Decrease in the tissue elasticity corresponds well with the morphological and histological change. 1. A histotripsy therapy system , comprising:an ultrasound therapy transducer configured to deliver histotripsy therapy pulses to tissue; andan ultrasound imaging transducer configured to generate shear waves and form elastography images from the shear waves, the ultrasound imaging transducer also being configured to detect varying degrees of tissue homogenization in the tissue resulting from the delivered histotripsy therapy pulses.2. The system of wherein the ultrasound therapy transducer is configured to deliver histotripsy therapy pulses having a peak negative pressure >10 MPa claim 1 , a duration <50 μs claim 1 , and a duty cycle <1%.3. The system of wherein the combination of the ultrasound therapy transducer and the ultrasound imaging transducer generates cavitation bubble clouds that increase the magnitude of pushing displacements available for elastography imaging to create higher resolution and improved image quality at greater target depths.4. The system of wherein the ultrasound therapy transducer and the ultrasound imaging transducer are aligned with a treatment zone of the tissue to apply an acoustic radiation force pushing from outside of the ...

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25-04-2013 дата публикации

Reflectance-facilitated ultrasound treatment and monitoring

Номер: US20130103028A1
Принадлежит: Liat Tsoref, Michael Kardosh, Yossi Gross

Apparatus comprising an ultrasound ablation system ( 10 ), which comprises a reflection-facilitation element ( 12 ), configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultra-sound tool ( 20 ), which comprises at least one ultrasound transducer ( 40 ) configured to be positioned within a heart chamber of the subject. The ultrasound transducer ( 40 ) is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.

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25-04-2013 дата публикации

INTEGRATED ABLATION AND MAPPING SYSTEM

Номер: US20130103064A1
Принадлежит: VytronUS, Inc.

A system for ablating and mapping tissue comprises a stand alone tissue ablation system adapted to ablate the tissue, and a stand alone cardiac mapping system adapted to map the tissue. The ablation system is operably coupled with the cardiac mapping system such that mapping data from the cardiac mapping system is provided to the ablation system to create a graphical display of the tissue and the ablation system position relative to the tissue. Motion of the ablation system may be monitored and adjusted based on feedback provided by ablation system actuators as well as position sensors. 1. A system for ablating and mapping tissue , said system comprising:a stand alone tissue ablation system adapted to ablate the tissue; anda stand alone cardiac mapping system adapted to map the tissue,wherein the ablation system is operably coupled with the cardiac mapping system such that mapping data from the cardiac mapping system is provided to the ablation system to create a graphical display of the tissue and the ablation system position relative to the tissue.2. The system of claim 1 , wherein the tissue ablation system comprises an actuatable catheter based ultrasound ablation system.3. The system of claim 2 , wherein the tissue ablation system comprises a low intensity collimated ultrasound ablation system.4. The system of claim 2 , wherein the catheter comprises at least one sensing element adjacent a distal portion of the catheter claim 2 , the at least one sensing element operably coupled with the cardiac mapping system.5. The system of claim 4 , wherein the cardiac mapping system is adapted to determine location of the at least one sensing element in space claim 4 , and wherein the cardiac mapping system graphically displays the location of the at least one sensing element superimposed on a representation of the tissue in a display device.6. The system of claim 5 , wherein the one or more sensors are adapted to capture intracardiac electrogram signals from the tissue ...

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02-05-2013 дата публикации

Targeted inhibition of physiologic and pathologic processes

Номер: US20130110012A1
Автор: Michael Gertner
Принадлежит: Kona Medical Inc

In some embodiments, sympathetic nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.

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09-05-2013 дата публикации

TRANSMISSIVE IMAGING AND RELATED APPARATUS AND METHODS

Номер: US20130116561A1
Принадлежит: Butterfly Network, Inc.

Apparatus and methods are described that include ultrasound imaging devices, which may operate in a transmissive ultrasound imaging modality, and which may be used to detect properties of interest of a subject such as index of refraction, density and/or speed of sound. Devices suitable for performing high intensity focused ultrasound (HIFU), as well as HIFU and ultrasound imaging, are also described. 1. An apparatus , comprising:a plurality of radiation sources comprising a first radiation source, a second radiation source, and a third radiation source;a first radiation sensor and a second radiation sensor; andprocessing circuitry coupled to the first radiation sensor and the second radiation sensor and configured to receive and discriminate between, for each of the first and second radiation sensors, respective source signals emitted by the first, second, and third radiation sources,wherein the first radiation source, the second radiation source, and the first radiation sensor lie in a first plane, andwherein the second radiation source, the third radiation source, and the second radiation sensor lie in a second plane different than the first plane.2. The apparatus of claim 1 , wherein the first radiation source is an ultrasound source.3. The apparatus of claim 2 , wherein the first radiation sensor and the second radiation sensor are ultrasound radiation sensors.4. The apparatus of claim 1 , wherein the processing circuitry is configured to receive and discriminate between claim 1 , for each of the first and second radiation sensors claim 1 , the respective source signals emitted by at least ten radiation sources of the plurality of radiation sources.5. The apparatus of claim 4 , wherein the processing circuitry is configured to receive and discriminate between claim 4 , for each of the first and second radiation sensors claim 4 , the respective source signals emitted by at least 100 radiation sources of the plurality of radiation sources.6. The apparatus of claim ...

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09-05-2013 дата публикации

Methods and Apparatus for Intracranial Ultrasound Delivery

Номер: US20130116603A1
Автор: Nita Henry
Принадлежит:

A method for delivering ultrasound energy to a patient's intracranial space involves forming at least one hole in the patient's skull, advancing at least one ultrasound delivery device at least partway through the hole(s), and transmitting ultrasound energy from the ultrasound delivery device(s). According to various embodiments, ultrasound delivery devices may be advanced into the epidural space, one or both ventricles and/or an intracerebral space of the patient's brain. In alternative embodiments, one or multiple holes may be formed in the skull, and any number of ultrasound delivery devices may be used. Intracranial ultrasound delivery may be used in diagnostic or therapeutic treatment of ischemic stroke, head trauma, atherosclerosis, perfusion disorders and other acute or chronic neurological conditions. 137-. (canceled)38. A method for treating blood clots in a patient's head , comprising:forming at least one aperture in the patient's head;positioning an ultrasound device within the at least one aperture;transmitting ultrasound energy from the ultrasound device at frequencies between 10 kHz and 10 Mhz to a treatment location; andevacuating blood clots outside of the patient's head.39. The method of claim 38 , wherein the ultrasound device is positioned on the patient's dura mater.40. The method of claim 38 , further providing a conductive medium which interfaces between the ultrasound device and the patient's head.41. The method of claim 40 , further including providing the conductive medium in the form of a compliant pack.42. The method of claim 40 , wherein conductive medium is selected from the group consisting of: gel claim 40 , oil claim 40 , saline claim 40 , and a combination of all three.43. The method of claim 38 , further comprising delivering at least one pharmacologic agent to the treatment location.44. The method of claim 38 , further comprising delivering bubbles or microbubbles to the treatment location.45. A method for treating blood clots in a ...

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09-05-2013 дата публикации

Ostial renal nerve ablation

Номер: US20130116687A1
Автор: Martin R. Willard
Принадлежит: Boston Scientific Scimed Inc

A catheter including an elongated shaft having a distal end and a proximal end, where the catheter includes a thermal element at the distal end thereof. The thermal element may be used in an ablation procedure or other procedure to heat a tissue adjacent a vessel. In some instances, the thermal element may be positioned in a first vessel and may operate to heat tissue adjacent a second vessel or adjacent an ostium between the first vessel and the second vessel. Further, the catheter may include an expandable portion on which the thermal element may be connected or positioned. The expandable portion(s) may comprise a basket or cage, a balloon, a memory shape and formable portion, and/or other mechanical expanders.

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16-05-2013 дата публикации

INTEGRATED ULTRASOUND ABLATION AND IMAGING DEVICE AND RELATED METHODS

Номер: US20130123625A1
Принадлежит: BOSTON SCIENTIFIC SCIMED, INC.

Intravascular nerve modulation systems and methods for making and using the same are disclosed. An example system may include an elongate shaft having a proximal end region and a distal end region and a central longitudinal axis. An ablation transducer may be disposed at the distal end region. The system may also include a rotational drive configured to rotate the ablation transducer about the central longitudinal axis. A control and power system may be operably connected to the ablation transducer and the rotational drive. In some instances, the ablation transducer may be a combined ablation and imaging transducer. 1. An intravascular nerve modulation system , comprising:an elongate shaft having a proximal end region and a distal end region and a central longitudinal axis;an ablation transducer disposed at the distal end region;a rotational drive configured to rotate the ablation transducer about the central longitudinal axis; anda control and power system operably connected to the ablation transducer and the rotational drive.2. The intravascular nerve modulation system of claim 1 , wherein the ablation transducer is a combined ablation and imaging transducer.3. The intravascular nerve modulation system of claim 1 , wherein the ablation transducer comprises a single planar ablation transducer.4. The intravascular nerve modulation system of claim 1 , wherein the ablation transducer comprises a plurality of ablation transducers claim 1 , the plurality of ablation transducers disposed in a single plane.5. The intravascular nerve modulation system of claim 1 , wherein the ablation transducer comprises a first ablation transducer and a second ablation transducer claim 1 , the second ablation transducer defining a first cavity in which the first ablation transducer is disposed.6. The intravascular nerve modulation system of claim 5 , wherein the ablation transducer further comprises a third ablation transducer claim 5 , the third ablation transducer defining a second ...

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16-05-2013 дата публикации

Dissection handpiece and method for reducing the appearance of cellulite

Номер: US20130123771A1
Принадлежит: Cabochon Aesthetics Inc

A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

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16-05-2013 дата публикации

Integrative atrial fibrillation ablation

Номер: US20130123773A1
Автор: Yitzhack Schwartz
Принадлежит: Biosense Webster Israel Ltd

Cardiac tissue ablation is carried out by defining first regions containing first locations including ganglionated plexi in a heart of a living subject, and inserting a probe into the heart. The method is further carried out by detecting electrical activity in the heart via electrodes on the distal portion of the probe, defining second regions having second locations, wherein the electrical activity exhibits a dominant frequency that is higher than a predefined threshold, defining third regions having third locations, wherein the electrical activity exhibits complex fractionated atrial electrograms, constructing an electroanatomical map of the heart that defines intersections of the first regions and at least one of the second regions and the third regions, selecting ablation sites within the intersections, and ablating cardiac tissue at the ablation sites.

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16-05-2013 дата публикации

SURGICAL SYSTEM

Номер: US20130123820A1
Принадлежит: OLYMPUS MEDICAL SYSTEMS CORP.

A surgical system includes a surgical instrument including a conducting section transmitting ultrasound vibration generated by an ultrasound transducer to a distal end portion and transmitting a high-frequency output signal to the distal end portion, an ultrasound drive section outputting an ultrasound drive signal to the ultrasound transducer, a high-frequency output section outputting a high-frequency output signal to the conducting section, a detection section detecting an ultrasound impedance of a surgical site to which ultrasound energy and high-frequency energy are provided from the distal end portion by outputting both signals simultaneously to the surgical instrument, a determination section determining whether the detected ultrasound impedance is in a predetermined range, and a control section performing control to increase a high-frequency output value by a first predetermined amount or decrease the high-frequency output value by a second predetermined amount when the detected ultrasound impedance is out of the predetermined range. 1. A surgical system comprising:a grasping section grasping a living biological tissue;a first energy output section applying first energy to the living biological tissue grasped by the grasping section;a second energy output section applying second energy which is a kind of energy different from the first energy to the living biological tissue grasped by the grasping section;a detection section detecting a physical amount that specifies a changes of energy passed through the living biological tissue, the physical amount being obtained by applying the first energy or the second energy to the living biological tissue;a storage section storing another physical amount different from the physical amount detected by the detection section, the other physical amount being determined beforehand so as to correspond to the physical amount detected by the detection section;a determination section determining whether or not the physical ...

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23-05-2013 дата публикации

PLANNING SYSTEM FOR TARGETING TISSUE STRUCTURES WITH ULTRASOUND

Номер: US20130131495A1

The disclosed subject matter provides systems and methods for targeting tissue structures and applying ultrasound thereto. A method according to the disclosed subject matter for targeting a tissue structure using corresponding tissue structure image data includes inputting the tissue structure image data into a targeting simulator, determining acoustic properties of the tissue structure from the corresponding tissue structure image data, and utilizing the determined acoustic properties to align a simulated transducer with the tissue structure such that the tissue structure is targeted. The method can further include acquiring the tissue structure image data, aligning the image data with an atlas of a body structure encompassing the tissue structure and/or selecting parameters of the simulated transducer such that a focal region of an ultrasound wave generated by the simulated transducer targets the tissue structure. 1. A method for targeting a tissue structure using corresponding tissue structure image data , comprising:receiving the tissue structure image data into a targeting simulator;determining one or more acoustic properties of the tissue structure from the corresponding tissue structure image data; andutilizing the determined one or more acoustic properties to align a simulated transducer with the tissue structure such that the tissue structure is targeted.2. The method of claim 1 , further comprising acquiring the tissue structure image data.3. The method of claim 2 , wherein the acquiring comprises acquiring a CT scan of at least the tissue structure.4. The method of claim 2 , wherein the acquiring comprises acquiring an MRI of at least the tissue structure.5. The method of claim 1 , further comprising aligning the tissue structure image data with an atlas of a body structure encompassing the tissue structure.6. The method of claim 1 , further comprising selecting parameters of the simulated transducer such that a focal region of an ultrasound wave ...

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23-05-2013 дата публикации

Recanalizing occluded vessels using radiofrequency energy

Номер: US20130131513A1
Автор: Osamu Katoh, Wayne Ogata
Принадлежит: RetroVascular Inc

A method and systems for treating chronic total occlusions, particularly those that are difficult to treat, is disclosed. In this approach, recanalizing the CTO is achieved using a combined antegrade and retrograde approach. The proximal end of the occlusion is penetrated using an antegrade wire, using a traditional approach. Using collateral vessels, the distal end of the occlusion is crossed in a retrograde fashion. By appropriately maneuvering each member and applying radiofrequency energy between the proximal and distal ends of the occlusion, a continuous channel is created.

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23-05-2013 дата публикации

ULTRASONIC PROBE

Номер: US20130131705A1
Автор: AKAGANE Tsunetaka
Принадлежит: OLYMPUS MEDICAL SYSTEMS CORP.

An ultrasonic probe includes a probe body which includes an outer peripheral portion provided along a longitudinal axis, and a void defining surface defining a void, which is open to an outside along the longitudinal axis in at least one part of the outer peripheral portion, along the longitudinal axis. The void defining surface defines the void in the probe body from a first anti-node position of the ultrasonic vibrations to a second anti-node position of the ultrasonic vibrations different from the first anti-node position. 1. An ultrasonic probe configured to transmit ultrasonic vibrations from a proximal end to a distal end , the ultrasonic probe comprising:a probe body which includes an outer peripheral portion provided along a longitudinal axis; anda void defining surface which defines a void in the probe body along the longitudinal axis from a first anti-node position of the ultrasonic vibrations to a second anti-node position of the ultrasonic vibrations different from the first anti-node position, the void being open to an outside along the longitudinal axis in at least one part of the outer peripheral portion.2. The ultrasonic probe according to claim 1 , wherein the void extends from a first perpendicular direction claim 1 , which is perpendicular to the longitudinal axis claim 1 , toward a second perpendicular direction claim 1 , which is opposite to the first perpendicular direction claim 1 , andat least a first-perpendicular-direction-side end. of the void defining surface is continuous with the outer peripheral portion of the probe body.3. The ultrasonic probe according to claim 2 , further comprising a cylindrical portion coupled to a distal direction side of the probe body claim 2 , an inside of the cylindrical portion being in communication with the void.4. The ultrasonic probe according to claim 3 , further comprising a tube extending through the void along the longitudinal axis claim 3 ,wherein the cylindrical portion includes a path defining ...

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30-05-2013 дата публикации

ULTRASOUND GUIDED AUTOMATED WIRELESS DISTRACTION OSTEOGENESIS

Номер: US20130138017A1
Принадлежит:

A bone distraction device applies guided incremental forces to opposing bone segments for the purpose of generating native bone in an osteotomy site (distraction osteogenesis). The bone distraction device automatically adjusts the rate of the distraction utilizing feedback received from the ultrasound transducer and other sensors, using an adaptive decision algorithm(s). A wireless transmitter allows for remote guidance, feedback and monitoring. 1. A bone distractor comprising:a first member couplable to a first portion of a bone to be distracted during use;a second member couplable to a second portion of a bone to be distracted at a position spaced across a separation in the bone from the attachment site of the first member during use;an actuator coupling the first member and the second member, wherein the actuator moves the second member relative to the first member during use;an sensor unit, wherein the sensor unit is positioned to determine physical characteristics of the callus between the first member and the second member during use, anda controller coupled to the actuator and the sensor unit, wherein the controller determines physical characteristics of the bone based on sensor readings obtained from the sensor unit during use, and wherein the controller operates the actuator in response to the determined physical characteristics of the bone during use.2. The distractor of claim 1 , wherein the sensor unit is an ultrasound unit claim 1 , wherein the controller determines physical characteristics of the bone based on ultrasound readings obtained from the ultrasound unit during use.3. The distractor of wherein the bone distractor is implantable.4. The distractor of claim 1 , further comprising a transmitter/receiver capable of transmitting and/or receiving control signals during use.5. The distractor of claim 1 , further comprising one or more reference elements coupled to the first member and/or the second member claim 1 , wherein the controller determines ...

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30-05-2013 дата публикации

NERVE TREATMENT SYSTEM

Номер: US20130138018A1
Автор: Gertner Michael
Принадлежит: Kona Medical, Inc.

A method of treatment includes delivering an agent into a patient, and providing energy inside the patient so that the energy can interact with the agent to treat a nerve. A system for treatment includes a source of agent for delivery into a patient, and an energy source for providing energy inside the patient so that the energy can interact with the agent to treat a nerve. 160-. (canceled)61. A therapeutic ultrasonic energy system , comprising:a transducer; anda processor coupled to the transducer;wherein the processor is configured to control the transducer so that the transducer delivers energy to treatment areas that are arranged approximately in a spherical or ellipsoidal configuration around a reference position associated with a blood vessel.62. The system of claim 61 , wherein the processor is configured to control one or more operation parameter for the transducer so that the transducer delivers the energy to nerve tissue on at least two sides of the blood vessel.63. The system of claim 61 , further comprising an intravascular catheter claim 61 , wherein the transducer is located on the catheter.64. The system of claim 63 , further comprising a positioning system for determining a position of the intravascular catheter.65. The system of claim 63 , wherein the transducer on the catheter is configured to deliver therapeutic energy.66. The system of claim 61 , wherein the transducer is configured to deliver the energy from outside a patient to inside the patient.67. The system of claim 61 , wherein the transducer is configured to deliver the energy from inside the blood vessel to outside the blood vessel.68. The system of claim 61 , further comprising a motion tracking module to track motion of the blood vessel.69. The system of claim 68 , wherein the motion tracking module is configured to track speckles.70. The system of claim 68 , wherein the motion tracking module is configured to determine a three dimensional coordinate of the blood vessel.71. The system ...

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30-05-2013 дата публикации

METHODS AND DEVICES TO MODULATE THE AUTONOMIC NERVOUS SYSTEM VIA THE CAROTID BODY OR CAROTID SINUS

Номер: US20130138095A1
Автор: Gertner Michael
Принадлежит: Kona Medical, Inc.

In some embodiments, sympathetic nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents. 119-. (canceled)20. A method to modulate an autonomic nerve in a patient comprising:positioning an energy delivery device at a position for delivery of energy to a carotid body or carotid sinus;determining a position of the carotid body or the carotid sinus relative to the position of the energy delivery device;determining a dose and a direction for the energy using the determined position of the carotid body or the carotid sinus relative to the position of the energy delivery device; anddelivering the energy from the energy delivery device to the carotid body or the carotid sinus.21. The method of claim 20 , wherein the act of positioning the energy delivery is performed via percutaneous access.22. The method of claim 20 , wherein the act of positioning the energy delivery device comprises placing the energy delivery device in a jugular vein.23. The method of claim 20 , wherein the act of positioning the energy deliver device comprises placing the energy delivery device in a carotid artery.24. The method of claim 20 , wherein the energy delivery device is configured to deliver radiofrequency energy claim 20 , and the act of delivering the energy comprises delivering the radiofrequency energy.25. The method of claim 20 , wherein the energy is delivered from outside a skin of the patient to the carotid body or the carotid sinus.26. The method of claim 20 , wherein the energy is delivered to the carotid body claim 20 , not the carotid sinus.27. The method of claim 20 , further comprising determining a functioning of an autonomic nervous system ...

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06-06-2013 дата публикации

Devices, systems and methods for magnetic-assisted therapeutic agent delivery

Номер: US20130139832A1
Принадлежит: Individual

Devices, systems and methods for magnetically assisted agent delivery are included. These devices, systems, and methods make use of a plurality of magnets or magnetic configuration.

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06-06-2013 дата публикации

DUAL MODE ULTRASOUND TRANSDUCER (DMUT) SYSTEM AND METHOD FOR CONTROLLING DELIVERY OF ULTRASOUND THERAPY

Номер: US20130144165A1
Принадлежит:

A dual-mode ultrasound system provides real-time imaging and therapy delivery using the same transducer elements of a transducer array. The system may use a multichannel driver to drive the elements of the array. The system uses a real-time monitoring and feedback image control of the therapy based on imaging data acquired using the dual-mode ultrasound array (DMUA) of transducer elements. Further, for example, multimodal coded excitation may be used in both imaging and therapy modes. Still further, for example, adaptive, real-time refocusing for improved imaging and therapy can be achieved using, for example, array directivity vectors obtained from DMUA pulse-echo data. 1. A dual mode ultrasound transducer system comprising:an array of ultrasound transducer elements, the ultrasound transducer elements configured to deliver a plurality of sequential therapy bursts of ultrasonic energy to at least a portion of a target region and to transmit/receive imaging ultrasonic energy to/from the target region; and control conveyance of imaging signals to/from one or more of the plurality of ultrasound transducer elements;', 'generate treatment region image data usable to identify at least one or more target points within a target region based on imaging signals conveyed to/from one or more of the plurality of ultrasound transducer elements;', 'generate therapy signals to drive one or more of the plurality of ultrasound transducer elements to deliver a plurality of sequential therapy bursts of ultrasonic energy to at least one of the one or more target points in the target region; and', 'generate control image data based on imaging signals from one or more of the plurality of ultrasound transducer elements during and/or following delivery of each therapy burst of a plurality of sequential therapy bursts, wherein the control image data generated during and/or following delivery of a therapy burst is used to generate therapy signals to drive one or more of the plurality of ...

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06-06-2013 дата публикации

ULTRASOUND NEUROMODULATION TREATMENT OF ANXIETY (INCLUDING PANIC ATTACKS) AND OBSESSIVE-COMPULSIVE DISORDER

Номер: US20130144192A1
Принадлежит: Neurotrek, Inc.

Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat anxiety (including panic attacks) and Obsessive-Compulsive Disorder. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. 1. A method of deep-brain neuromodulation using ultrasound stimulation , the method comprising:aiming an plurality of ultrasound transducer at one or a plurality of neural targets, andapplying pulsed power to the ultrasound transducer via a control circuit,whereby the condition treated is selected from the group consisting of anxiety, (including panic attacks) and Obsessive-Compulsive Disorder.2. The method of claim 1 , whereby:a. ultrasound is transmitted into the brain at a plurality of ultrasound transducers targets one or a plurality of brain regions related to anxiety, panic attacks, obsessive compulsive disorder, or a subject's sense of relaxation, sense of being at peace, or sense of being free from agitation, excitement, disturbance, or stress;b. the dominant acoustic frequency is greater than about 100 kHz and less than about 10 MHz;{'sub': 'spta', 'sup': '2', 'c. the spatial-peak temporal-average (I) intensity of the ultrasound waveform at the site of cells to be modulated is less than about 1 W/cm;'}d. the ultrasound pulse length is less than about 5 seconds; ande. the transmitted ultrasound induces an effect in one or more brain regions such as neuromodulation, brain activation, neuronal activation, neuronal inhibition, or a change in blood flow whereby heating of brain tissue does not exceed approximately 2 degrees Celsius for a period greater than about 5 seconds.3. The method of claim 1 , whereby the effect on a subject is a ...

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06-06-2013 дата публикации

HYDROGEL ULTRASOUND COUPLING DEVICE

Номер: US20130144193A1
Принадлежит: ZETROZ LLC

The present invention relates to an ultrasound coupling device that includes a gel component and a coupling compartment. The present invention also relates to various kits and methods for using the ultrasound coupling device with low-intensity ultrasound transducers and therapy. The present invention also relates to methods of making the ultrasound coupling device of the present invention. The present invention further relates to an array that includes a plurality of ultrasound coupling devices of the present invention, and methods of using the array. 1. An ultrasound coupling device comprising:a gel component comprising a gel material effective to conduct acoustic energy; anda coupling compartment comprising a wall-like structure effective for holding the gel component in place,wherein said wall-like structure comprises a continuous or substantially continuous sidewall, a top surface for interfacing with a subject, and a bottom surface and/or side surface for interfacing with an ultrasound transducer, andwherein said gel component is contained at least within a portion of the sidewall of the wall-like structure of the coupling compartment.2. The coupling device according to claim 1 , wherein said gel material is selected from the group consisting of a gel claim 1 , a gel-like composition claim 1 , a hydrogel claim 1 , a low density cross-linked polymer hydrogel claim 1 , and the like.3. The coupling device according to claim 1 , wherein said gel component is in the form of a wafer having any two-dimensional geometric shape.4. The coupling device according to claim 3 , wherein the wafer has a thickness of between about 0.25 mm and about 5.0 mm claim 3 , and a shape to accommodate the entire face of the ultrasound transducer.5. The coupling device according to claim 3 , wherein said two-dimensional geometric shape can be of any shape claim 3 , including an arbitrary or custom shape claim 3 , or a shape selected from the group consisting of a circle claim 3 , oval ...

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06-06-2013 дата публикации

METHOD AND APPARATUS FOR MAKING ULTRASONIC IRRADIATION PLAN BASED ON ANATOMICAL FEATURES

Номер: US20130144194A1
Автор: AHN Min-su, BANG Won-chul
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

A method of making an ultrasonic irradiation plan includes receiving image data representing anatomical features of a target object, generating information about at least one portion of the target object that is to be irradiated with ultrasound from the image data representing the anatomical features of the target object, and making an ultrasonic irradiation plan for irradiating the target object with ultrasound by simulating irradiating the target object with ultrasound based on the generated information. 1. A method of making an ultrasonic irradiation plan , the method comprising:receiving image data representing anatomical features of a target object;generating information about at least one portion of the target object that is to be irradiated with ultrasound from the image data representing the anatomical features of the target object; andmaking an ultrasonic irradiation plan for irradiating the target object with ultrasound by simulating irradiating the target object with ultrasound based on the generated information.2. The method of claim 1 , wherein the generating of the information comprises designating any one or any combination of a first portion of the target object that is to be irradiated with the ultrasound claim 1 , a second portion of the target object that the ultrasound is to avoid claim 1 , and a third portion of the target object that has a characteristic of disrupting propagation of the ultrasound.3. The method of claim 2 , wherein the making of the ultrasonic irradiation plan comprises:determining whether the ultrasound collides with the second portion or the third portion while virtually irradiating the first portion with the ultrasound using a virtual transducer; anddetermining a location of the virtual transducer at which irradiating the target object with the ultrasound is allowed based on a result of the determining of whether the ultrasound collides with the second portion or the third portion.4. The method of claim 3 , further ...

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13-06-2013 дата публикации

Catheter balloon methods and apparatus employing sensing elements

Номер: US20130150693A1
Принадлежит: Individual

An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.

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13-06-2013 дата публикации

Magnetic resonance imaging methods for rib identification

Номер: US20130150704A1
Принадлежит: Individual

A method for spatially localizing a rib cage prior to transcostal ultrasound treatment of visceral tissue includes computationally refining a three-dimensional model of the rib cage based on image slices taken at multiple locations along the ribs with orientations dependent on local rib orientations.

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13-06-2013 дата публикации

Ultrasound probe head comprising an imaging transducer with a shielding element

Номер: US20130150715A1
Автор: Lacoste Francois
Принадлежит: THERACLION SAS

The present invention relates to an ultrasound probe head (), especially for HIFU treatment, comprising a treatment ultrasound transducer () and an imaging ultrasound transducer (). The imaging transducer () comprises a shield element () configured such that most of the energy of ultrasound waves () reflected in the direction of the imaging transducer () are held back by said shield element (). The shield element () is configured in such a way as not to interfere with the emission of the imaging ultrasound waves (). 116-. (canceled)17. An ultrasound probe head for the treatment of an organ or tissue comprising:at least one treatment transducer for emission of ultrasound waves; andat least one imaging transducer;wherein said imaging transducer comprises a shield element limiting the exposure of the imaging transducer such that ultrasound waves generated by the treatment transducer and reflected at a boundary in the direction of the imaging transducer are at least partly held off by said shield element and such that ultrasound waves emitted from said imaging transducer are not obstructed by said shield element.18. Ultrasound probe head as claimed in claim 17 , wherein at least 75 of the energy of ultrasound waves from the treatment transducer reflected in the direction of the imaging transducer is held off by the shield element.19. Ultrasound probe head as claimed in claim 17 , wherein said shield element comprises or is made of a polymeric mate-rial.20. Ultrasound probe head as claimed in claim 17 , wherein the treatment transducer is in the form of a spherical cap.21. Ultrasound probe head as claimed in claim 17 , wherein the imaging transducer is of rectangular shape.23. Ultrasound probe head according to claim 17 , wherein the at least one wall of the shield element has a height H of at least 4 mm.24. Ultrasound probe head as claimed in claim 17 , wherein said shield element has a maximal thickness of at least 1.5 mm.25. Ultrasound probe head as claimed in claim ...

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20-06-2013 дата публикации

Devices and Methods for the Treatment of Endometriosis

Номер: US20130158347A1
Принадлежит: BOSTON SCIENTIFIC SCIMED, INC.

A tissue treatment device comprises an insertion section sized and shaped for insertion into the body via a trocar and a diagnostic element coupled to the insertion section, the diagnostic element illuminating tissue with light of a wavelength selected to facilitate identification of target tissue in combination with an ultrasound element coupled to the insertion section for delivering to a portion of tissue illuminated by the diagnostic element ultrasound energy. 120.-. (canceled)21. A tissue treatment device , comprising:an insertion section sized and shaped for insertion into a body;a diagnostic element coupled to the insertion section, the diagnostic element configured to illuminate a target area with a first light of a first wavelength and a second light of a second wavelength selected to facilitate identification of a select portion of a target tissue; andan ultrasound element coupled to the insertion section, the ultrasound element including a generating component that generates ultrasound energy for delivery to the select portion of the target tissue,wherein the diagnostic element and the ultrasound element are positioned and oriented within the insertion section such that the second light from the diagnostic element and the ultrasound energy from the generating component converge on a target spot.22. The device according to claim 21 , further comprising a control unit coupled to the diagnostic element and the ultrasound element claim 21 , the control unit remaining outside the body while the insertion section is inserted into the body.23. The device according to claim 22 , wherein the ultrasound element is coupled to an ultrasound controller located in the control unit.24. The device according to claim 23 , wherein the diagnostic element comprises a first illuminating component configured to generate the first light and a second illuminating component configured to generate the second light.25. The device according to claim 24 , wherein the first and second ...

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20-06-2013 дата публикации

MRI THERMAL IMAGING OF WATER TISSUE AND FAT TISSUE USING TRANSVERSE RELAXOMETRY DATA AND PROTON RESONANCE FREQUENCY SHIFT DATA

Номер: US20130158387A1
Автор: Tanttu Jukka Ilmari
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

An apparatus () comprising a magnetic resonance imaging system (), the magnetic resonance imaging system comprising: a magnet () adapted for generating a magnetic field for orientating the magnetic spins of nuclei of a subject () located within an imaging volume (); a radio frequency transceiver () adapted for acquiring magnetic resonance data () using a radio frequency coil (); a computer system () comprising a processor (), wherein the computer system is adapted for controlling the apparatus; and a memory () containing machine readable instructions (), wherein execution of the instructions cause the processor to perform the steps of: acquiring () magnetic resonance data using the magnetic resonance imaging system, wherein the magnetic resonance data comprises transverse relaxometry data, and calculating () the temperature of the subject within a temperature measurement volume () in accordance with the transverse relaxometry data. 1. An apparatus comprising a magnetic resonance imaging system , the magnetic resonance imaging system comprising:a magnet adapted for generating a magnetic field for orientating the magnetic spins of nuclei of a subject located within an imaging volume;a radio frequency transceiver adapted for acquiring magnetic resonance data using a radio frequency coil;a magnetic field gradient coil adapted for spatial encoding of the magnetic spins of nuclei within the imaging volume;a magnetic field gradient coil power supply adapted for supplying current to the magnetic field gradient coil;a computer system comprising a processor, wherein the computer system is adapted for controlling the apparatus; and acquiring magnetic resonance data using the magnetic resonance imaging system, wherein the magnetic resonance data comprises transverse relaxometry T2 or T2 star data, as well as proton resonance frequency shift data, wherein at least the transverse relaxometry T2 or T2 star data is acquired using a turbo spin echo (TSE) sequence, and', 'calculating ...

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20-06-2013 дата публикации

TREATMENT PLANNING SYSTEMS AND METHODS FOR BODY CONTOURING APPLICATION

Номер: US20130158440A1
Автор: Allison John W.
Принадлежит: Zeltiq Aesthetics, Inc.

Methods and system for treatment planning for non- and minimally-invasive alteration of body adipose tissue for reduction and contouring of body fat are described herein. Treatment plans can be generated by capturing current body part data (e.g., positioning, contour/shape, thickness of adipose tissue, etc.), determining desired outcome of treatment (e.g., percent reduction of adipose tissue thickness, degree of contour change, etc.), and determining treatment parameters to achieve desired results. Algorithms can be used to determine best-fit treatment parameters to use in treatment sessions. In some embodiments, the system can provide a predictive end-result image for communication to patient and/or for determining alteration of desired outcome. In various embodiments, real-time monitoring of feedback data can be used to determine treatment plan efficacy. Additional algorithms can provide real-time comparison of feedback data to anticipated feedback data, and can be used to change treatment parameters in real-time to achieve desired effects. 151.-. (canceled)52. A method performed using a treatment system for non-invasively and transdermally altering a patient's subcutaneous fat , the method comprising:receiving, by the treatment system, patient information, the patient information including target region information that indicates a target region of the patient;receiving, by the treatment system, treatment session information, the treatment session information is associated with a number of treatment sessions for the patient; andtransmitting the patient information and the treatment session information over a network; andstoring the transmitted patient information and the transmitted treatment session information.53. The method of claim 52 , further comprising manually inputting the patient information into a client computer of the treatment system.54. The method of claim 52 , further comprising manually inputting the treatment session information into a client ...

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20-06-2013 дата публикации

METHODS FOR THERMALLY-INDUCED RENAL NEUROMODULATION

Номер: US20130158441A1
Принадлежит: Ardian, Inc.

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. 1. A method for thermally-induced renal neuromodulation of a human patient , the method comprising:delivering a renal neuromodulation device to a vicinity of a neural fiber that contributes to renal function of the patient; andthermally inducing modulation of a function of the neural fiber with the renal neuromodulation device such that the neural fiber is thermally altered.2. The method of wherein thermally inducing modulation of a function of the neural fiber further comprises directly applying thermal energy to the neural fiber.3. The method of wherein thermally inducing modulation of a function of the neural fiber further comprises indirectly applying thermal energy to the neural fiber.4. The method of wherein thermally inducing modulation of a function of the neural fiber further comprises delivering a thermal electric field to the neural fiber via at least one electrode.5. The method of wherein:delivering a renal neuromodulation device to a vicinity of the neural fiber further comprises intravascularly delivering the renal neuromodulation device; anddelivering a thermal electric field to the neural fiber via at least one electrode further comprises delivering the thermal electric field via at least one wall-contacting electrode.6. The method of claim 1 , further comprising monitoring a parameter of (a ...

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20-06-2013 дата публикации

METHODS FOR THERMALLY-INDUCED RENAL NEUROMODULATION

Номер: US20130158442A1
Принадлежит: Ardian, Inc.

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. 1. A method of treating a human patient diagnosed with a cardio-renal disease or disorder , the method comprising:intravascularly delivering a device to a vicinity of a neural fiber associated with renal function of the patient; andthermally inhibiting neural communication along the neural fiber with the device.2. The method of wherein thermally inhibiting neural communication along the neural fiber with the device comprises thermally inhibiting afferent neural communication along the neural fiber with the device.3. The method of wherein thermally inhibiting neural communication along the neural fiber with the device comprises thermally inhibiting efferent neural communication along the neural fiber with the device.4. The method of wherein intravascularly delivering a device to a vicinity of a neural fiber associated with renal function comprises intravascularly delivering the device via a renal blood vessel to a position proximate to the neural fiber.5. The method of wherein intravascularly delivering the device via a blood vessel to a position proximate to the neural fiber comprises intravascularly positioning the device in contact with a wall of the blood vessel proximate to the neural fiber.6. The method of wherein thermally inhibiting neural communication along the neural fiber with the device ...

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