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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 118511. Отображено 100.
05-01-2012 дата публикации

Dispersion composition and method for manufacturing dispersion composition

Номер: US20120003288A1
Автор: Hisahiro Mori
Принадлежит: Fujifilm Corp

The present invention provides: a dispersion composition including a poorly water-soluble polyphenol compound, an emulsifier including a sucrose fatty acid ester, and a water-soluble polymer, in which a content of a polyglycerin fatty acid ester in the composition is 0, or 0.1 or fewer times a total mass of the sucrose fatty acid ester in the composition, and a particle size of the dispersed particles including the poorly water-soluble polyphenol is 200 nm or smaller; and a method for manufacturing the dispersion composition, the method including an oil phase preparation process in which an oil phase is prepared by dissolving one or more oil phase components including the poorly water-soluble polyphenol in a good solvent for the poorly water-soluble polyphenol compound, and a mixing process in which the obtained oil phase and a phase of a poor solvent for the poorly water-soluble polyphenol compound are mixed to obtain the dispersion composition which includes the poorly water-soluble polyphenol compound and includes dispersed particles having an average volume particle size of 200 nm or smaller.

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Номер записи: 1
05-01-2012 дата публикации

Composition Comprising Vascular Endothelial Growth Factor (VEGF) for the Treatment of Hair Loss

Номер: US20120003300A1
Автор: Elliot Isaacs, Toby Cobbledick
Принадлежит: Pangaea Laboratories Ltd

A composition to treat hair loss and enhance hair growth and condition. The composition comprises: i) one or more of VEGF, a VEGF biomimetic peptide, and/or a VEGFR2 receptor agonist; ii) ciclopirox olamine; and iii) a pharmaceutically acceptable carrier.

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Номер записи: 2
05-01-2012 дата публикации

Formulation Comprising Bioactive Agents And Method Of Using Same

Номер: US20120004170A1
Автор: Daniel Schwartz, Susan J. Sofia, Wolfgang Friess
Принадлежит: Friedrich Alexander Univeritaet Erlangen Nuernberg FAU

Disclosed are methods of making bioactive BMP-2 microparticles and methods of using the microparticles.

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Номер записи: 3
05-01-2012 дата публикации

Methods of using a methylxanthine compound

Номер: US20120004248A1
Автор: Clifford S. Deutschman, Richard J. Levy
Принадлежит: Deutschman Clifford S, Levy Richard J

The invention relates to compositions and methods for treating various diseases or medical conditions by administering a methylxanthine compound. Specifically, the invention relates to compositions and methods for treating cytochrome oxidase (CcOX) mediated diseases or medical conditions by administering compositions comprising a methyl xanthine compound.

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Номер записи: 4
05-01-2012 дата публикации

Use Of Serine Protease Inhibitors In The Treatment Of Neutropenia

Номер: US20120004395A1
Автор: Adriano Fontana, Christoph Kundig, Mike Recher
Принадлежит: MED DISCOVERY SA, Universitaet Zuerich

The invention relates to therapeutic compounds which are inhibitors of serine proteases, to pharmaceutical compositions thereof and to their use in the treatment of the human or animal body. More specifically, the present invention relates to a method for the treatment of neutropenia comprising the administration to a subject in need thereof of a therapeutically effective amount of a serine protease inhibitor. The invention also comprises prevention of apoptosis of myeloid cells (1) during and after transfection of bone marrow cells performed for gene therapy, (2) during blood stem cell mobilization performed for reconstitution of hematopoiesis and (3) during infusion of cells of the myeloid lineage for reconstitution of hematopoiesis for gene therapy or for treatment of neutropenia by infusion of neutrophils.

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Номер записи: 5
05-01-2012 дата публикации

In vitro micro-organs, and uses related thereto

Номер: US20120004642A1
Автор: Eduardo N. Mitrani
Принадлежит: Yissum Research Development Co of Hebrew University of Jerusalem

Micro-organ cultures which include isolated populations of cells having specific characteristics are described. Salient features of the subject micro-organ cultures include the ability to be maintained in culture for relatively long periods of time, as well as the preservation of an organ microarchitecture which facilitates, for example, cell-cell and cell-matrix interactions analogous to those occurring in the source organ. The micro-organ cultures of the invention can be used in methods for delivering gene products to recipient subjects, for identifying cell proliferative and cell differentiating agents, and identification and isolation of progenitor and stem cells. In addition, the micro-organ cultures of the present invention can be used in methods for identifying inhibitors of cell proliferation, cell differentiation and viral infectivity. In other embodiments, the micro-organ cultures can be used for transplantation.

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Номер записи: 6
12-01-2012 дата публикации

Choline and tromethamine salt of licofelone

Номер: US20120010261A1
Автор: Hans-Günter Striegel, Stefan Laufer, Wolfgang Albrecht
Принадлежит: CAIR Biosciences GmbH

The present invention relates to the choline and tromethamine salt of Licofelone.

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Номер записи: 7
12-01-2012 дата публикации

Avermectin compounds and treatment of dermatological disorders in humans therewith

Номер: US20120010277A1
Автор: Alexandre Kaoukhov, Cecile Cousin
Принадлежит: GALDERMA SA

Compounds of the avermectin family or derivatives thereof, notably latidectin, are formulated into pharmaceutical compositions useful for the treatment of dermatological conditions in humans, in particular rosacea.

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Номер записи: 8
12-01-2012 дата публикации

Improved chemical synthesis of diazaindoles by chichibabin cyclization

Номер: US20120010409A1
Автор: Franz J. Weiberth, George E. Lee, II Frederick L. Shrimp
Принадлежит: SANOFI SA

An improved synthesis method for making diazaindoles using a Chichibabin cyclization is disclosed. In particular, this method is useful for making the compound of Formula I.

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Номер записи: 9
19-01-2012 дата публикации

Soothing cosmetic or pharmaceutical composition comprising a peptide which activates hmg-coa reductase

Номер: US20120014886A1
Автор: Claude Dal Farra, Jean-Marie Botto, Nouha Domloge
Принадлежит: ISP Investments LLC

The present invention relates to a soothing cosmetic or pharmaceutical composition comprising at least one peptide that activates human HMG-CoA reductase of general formula (I): R 1 -(AA) n -X 1 -Gly-Lys-X 2 -(AA) p -R 2 and sequence SEQ ID No. 1 to SEQ ID No. 10, in a physiologically suitable medium. The present invention further relates to the utilization of this novel peptide as a soothing active principle in a cosmetic composition. The invention further applies to a cosmetic treatment method intended to combat skin irritations.

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Номер записи: 10
19-01-2012 дата публикации

Formulations for the treatment of urushiol-induced contact dermatitis

Номер: US20120015044A1
Автор: Angela Hansen, Laszlo TREIBER
Принадлежит: Laszlos Solutions Inc

Disclosed herein are compositions comprising: a pharmaceutically acceptable oxidizing agent; a pharmaceutically acceptable base; and a pharmaceutically acceptable solvent or mixture of solvents. Also disclosed are methods of treating urushiol-induced contact dermatitis in a patient, the method comprising: identifying a patient in need thereof; and administering to the patient a composition as described herein. Further disclosed herein are devices for the treatment of urushiol-induced contact dermatitis, the device comprising: an absorbent material, contained therein a composition as described herein; and means for attaching the device to the skin of a patient in need thereof.

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Номер записи: 11
19-01-2012 дата публикации

Pharmaceutical composition for external use

Номер: US20120015997A1
Автор: Akira Nozawa, Hirokazu Kobayashi, Hiroyuki Fujii, Toyohiko Miki
Принадлежит: Nihon Nohyaku Co Ltd, Pola Pharma Inc

Provided is a pharmaceutical composition for external use, including: (i) a compound represented by structural formula (2) and/or a salt thereof; and (ii) N-methyl-2-pyrrolidone.

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Номер записи: 12
19-01-2012 дата публикации

Phototherapy methods and devices comprising emissive aryl-heteroaryl compounds

Номер: US20120015998A1
Автор: Amane Mochizuki, Brett T. Harding, Jensen Cayas, Keisaku Okada, Sazzadur Rahman Khan, SHENG Li, Shijun Zheng
Принадлежит: Nitto Denko Corp

Disclosed herein are compounds represented by a formula: R 1 —Ar 1 —X—Ar 2 —Ar 3 -Het, wherein R 1 , Ar 1 , X, Ar 2 , Ar 3 , and Het are described herein. Compositions and light-emitting devices related thereto are also disclosed.

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Номер записи: 13
19-01-2012 дата публикации

Biphenyl compound selective agonists of gamma rar receptors

Номер: US20120016031A1
Автор: Etienne Thoreau, Thibaud Biadatti
Принадлежит: Galderma Research and Development SNC

Biphenyl compounds having the formula (I): are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.

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Номер записи: 14
26-01-2012 дата публикации

Methods for accelerating wound healing by administration of adipokines

Номер: US20120020917A1
Автор: Inessa Solomonik, Liora Braiman-Wiksman
Принадлежит: Individual

Methods for inducing or accelerating a healing process of a damaged skill or skin wounds are described. The methods include administering to the skin cells colonizing the damaged skin or skin wound a therapeutically effective amount of an adipokine, an adipocyte or preadipocyte modulator, adipocytes, preadipocytes, or stem cells, or transforming the skin cells colonizing the damaged skin or skin wound such as to express and secrete an adipokine, thereby inducing or accelerating the healing process of the damaged skin or skin wound.

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Номер записи: 15
26-01-2012 дата публикации

METHODS FOR TREATING IgE-MEDIATED DISORDER

Номер: US20120020979A1
Автор: Andrea Cerutti, KANG Chen
Принадлежит: CORNELL UNIVERSITY

This invention relates to methods of treating IgE mediated disorders such as allergy and asthma based on activating surface-bound IgD molecules on basophils. The invention also relates to methods of making IgD, as well as methods of screening for antimicrobial agents from IgD-activated basophils.

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Номер записи: 16
26-01-2012 дата публикации

Formulations and treatments for trichology

Номер: US20120020982A1
Автор: Jon Phillips
Принадлежит: Individual

A formulation for trichological treatment of a patient including, in a dosage in the range of 3 g to 8 g: phytosterols in the range of 200 mg to 2500 mg; the quantitative equivalent of Polygonum multiflorum root 4:1 in 70% EW in the range of 600 mg to 2600 mg; methylsulfonylmethane in the range of 500 mg to 2000 mg; and bovine colostrum in the range of 500 m to 2000 m.

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Номер записи: 17
26-01-2012 дата публикации

Corrosion current-generating metal particulates and use thereof

Номер: US20120021014A1
Автор: Brooks Story, Chunlin Yang, James E. Hauschild, Jeannette Chantalat, Jeffrey C. Geesin, Jue-Chen Liu, Julia Hwang, Michael D. Southall, Wei Kong, William R. Parrish, Ying Sun
Принадлежит: Johnson and Johnson Consumer Companies LLC

Metal particulates capable of generating low levels of corrosion current beneficial for pharmaceutical, cosmetic and other medical uses are provided.

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Номер записи: 18
02-02-2012 дата публикации

Thermoreversible collagen

Номер: US20120027732A1
Автор: Sherry L. Voytik-Harbin
Принадлежит: PURDUE RESEARCH FOUNDATION

This invention relates to collagen formulations. More particularly, this invention relates to thermoreversible collagen formulations and methods of their use and preparation.

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Номер записи: 19
02-02-2012 дата публикации

Methods for treating adult respiratory distress syndrome

Номер: US20120027742A1
Автор: Jahar Bhattacharya, Sadiqa K. Quadri, Shonit Das
Принадлежит: Columbia University of New York

We have discovered that the activated phosphorylated form of focal adhesion kinase (hereafter “FAKp”) strengthens the microvascular endothelial cell (EC) junctions that form a barrier in pulmonary endothelia, and the increased barrier helps to prevent acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Thus certain embodiments of the invention are directed to prevention and treatment of ALI and ARDS by administering a therapeutically effective amount of FAKp to subjects at risk of developing or diagnosed as having either ALI or ARDS.

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Номер записи: 20
02-02-2012 дата публикации

Cosmetic compositions comprising oridonin and new cosmetic uses

Номер: US20120028916A1
Автор: Arnaud Fournial, Philippe Mondon
Принадлежит: Sederma SA

The present invention related to cosmetic compositions comprising oridonin and new cosmetic uses. Oridonin is used for fighting the signs of cutaneous aging and for slimming. A composition comprising a combination of oridonin and darutigenol or a derivative thereof, in particular darutoside, is disclosed together with the cosmetic use of such composition.

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Номер записи: 21
02-02-2012 дата публикации

Medicinal Cream Made Using Neomycin Sulphate, Betamethasone Valerate, And Chitosan, And A Process To Make The Same

Номер: US20120028942A1
Автор: Haridas Sankar, Kuppusamy Senthilkumar, Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Vanangamudi Subramaniam Sulur
Принадлежит: Apex Labs Private Ltd

The present invention is directed to a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antibacterial active ingredient. It discloses a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs), neomycin sulphate & betamethasone valerate used in treating bacterial skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, a corticosteroid Betamethasone Valerate, and an antibacterial agent Neomycin Sulphate, are incorporated in cream base for use in treating bacterial skin infections and skin inflammation due to allergy & itching, & wounds on human skin involving contacting human skin with the above identified composition.

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Номер записи: 22
09-02-2012 дата публикации

Ophthalmic preparation containing menthyl ester of indomethacin

Номер: US20120034278A1
Автор: Joseph Schwarz, Michael Weisspapir
Принадлежит: Alpharx Inc

There is provided an ophthalmic pharmaceutical preparation comprising menthyl ester of indomethacin as an active ingredient. Also provided are different possible formulations of the ophthalmic preparation, and different methods of treating ophthalmic irritation using the ophthalmic preparation.

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Номер записи: 23
09-02-2012 дата публикации

Methods for applying a skin graft

Номер: US20120035619A1
Автор: Andrew Ziegler, M. Josh Tolkoff, Sameer Ahmed Sabir
Принадлежит: Momelan Technologies Inc

The present invention generally relates to methods for applying a skin graft. Methods of the invention involve harvesting an epidermal skin graft, and applying the epidermal skin graft to a recipient site such that the basal layer of the skin graft makes direct contact with the recipient site.

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Номер записи: 24
16-02-2012 дата публикации

Methods of treating pain

Номер: US20120039866A1
Автор: Daniela Salvemini
Принадлежит: St Louis University

The invention relates to methods for treating pain disorders including neuropathic and inflammatory pain and to methods to reduce or eliminate nociceptive tolerance induced by opiate analgesic use by administering an agent that suppresses or blocks S1P biological activity.

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Номер записи: 25
16-02-2012 дата публикации

Human monoclonal antibody against a costimulatory signal transduction molecule ailim and pharmaceutical use thereof

Номер: US20120039874A1
Автор: Katsunari Tezuka, Nobuaki Hori, Takashi Tsuji
Принадлежит: Japan Tobacco Inc

Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety of biological reactions (for example, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.) associated with AILIM-mediated costimulatory signal (secondary signal) transduction. Furthermore, it has been revealed that the human monoclonal antibody is effective to treat and prevent various diseases associated with AILIM-mediated costimulatory signal transduction, being capable of inhibiting the onset and/or advancement of the diseases.

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Номер записи: 26
16-02-2012 дата публикации

Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use

Номер: US20120039980A1
Автор: David M. Gravett, George Y. Daniloff, Jacqueline Schroeder, Louis C. Sehl, Olof Mikael Trollsas, Philip M. Toleikis
Принадлежит: AngioDevice International GmbH

Methods of preventing adhesion between issues are provided that utilizes in situ crosslinked biomaterials. The biomaterial contains at least the crosslinked product of two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Exemplary uses for the crosslinked compositions include preventing adhesions following surgery or injury, and preventing scar tissue formation.

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Номер записи: 27
16-02-2012 дата публикации

Brimonidine compositions for treating erythema

Номер: US20120040016A1
Автор: Christopher V. Powala, Klaus P. Theobald
Принадлежит: Individual

The present invention is directed to a pharmaceutical composition including brimonidine tartrate in an amount from about 0.17 percent by weight to about 0.19 percent by weight in a pharmaceutically acceptable carrier such as a gel or cream. The invention also relates to a method of treating erythema in a patient with rosacea by administering the composition of the invention to the site of erythema on the skin of the patient.

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Номер записи: 28
16-02-2012 дата публикации

Collagen peptide composition having good ability to enter the blood and food or beverage containing the same

Номер: US20120040055A1
Автор: Hidetoshi Nishizawa, Hiroki Ohara, Hitoshi Matsumoto, Koichi Terauchi, Masataka Hata
Принадлежит: Meiji Co Ltd

An object of the present invention is to elucidate a collagen peptide effective for causing dipeptides or tripeptides serving as the active component to enter the blood, and thus to reduce the required intake thereof. According to the present invention, a collagen peptide composition obtained by digesting collagen or gelatin with protease is provided, wherein: (a) the ratio of hydroxyproline to total of amino acid residues at the second position from the N terminus of the peptides in the composition is 2 mol % or more and 20 mol % or less, and the ratio of glycine to total of amino acid residues at the third position from the N terminus of the peptides in the composition is 20 mol % or more and 50 mol % or less; and (b) the average molecular weight is 500 or more and 2000 or less.

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Номер записи: 29
16-02-2012 дата публикации

Novel biomaterials, their preparation and use

Номер: US20120040901A1
Автор: Christian Schoch, György Lajos KIS, Jozsef Szejtli, Lajos Szente
Принадлежит: Individual

The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.

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Номер записи: 30
23-02-2012 дата публикации

STABLE PHARMACOLOGICALLY ACTIVE COMPOSITIONS INCLUDING VITAMIN D CONTAINING AND CORTICOSTEROID COMPOUNDS WITH LOW pH COMPATIBILITY

Номер: US20120046253A1
Автор: Michael Fox, Rakefet Cohen
Принадлежит: Teva Pharmaceutical Industries LTD

Provided are pharmaceutical compositions comprising at least one vitamin D-containing compound, at least one corticosteroid compound, and at least one solvent component selected from the group consisting of triglycerides, sorbitan, sorbitan fatty esters, cetearyl glucoside, PEG-n sorbitan stearate, acrylamide/sodium acryloyldimethyl taurate copolymers, and mixtures thereof. Also provided are methods of making such compositions, and methods for treating psoriasis using such compositions.

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Номер записи: 31
01-03-2012 дата публикации

(R)-(-)-1,2-propanediol compositions and methods

Номер: US20120053152A1
Автор: Edward T. Wei
Принадлежит: Individual

Short-chain 2- to 3-carbon alcohols are used as solvents for cooling agents in the preparation of topical therapeutic and cosmetic formulations. Some of these alcohols, especially ethanol, inhibit the ability of the cooling agent to activate its target receptor. In one embodiment of this invention, (R)-1,2-propanediol is used as an alcoholic solvent for the topical delivery of cooling agents to biological surfaces. This propanediol enantiomer has a minimum inhibitory effect on cooling with respect to standard 2- to 3-carbon alcoholic solvents, and functions to substantially protect the agent's cooling activity from inhibition when in the presence of a short-chain alcohol.

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Номер записи: 32
08-03-2012 дата публикации

Treatment of cutaneous hemangioma

Номер: US20120058056A1
Автор: Suqin Guo
Принадлежит: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

This invention concerns a method of treating hemangiomas with a beta blocker by applying the beta blocker onto the hemangiomas directly. The invention also concerns a combination therapy by using a beta blocker along with a corticosteroid or an alpha adrenergic receptor agonist for the treatment of hemangiomas.

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Номер записи: 33
08-03-2012 дата публикации

Two component interactive emulsion product

Номер: US20120058062A1
Автор: John C. Carson
Принадлежит: Carson Product Development Inc

The present invention describes, in one aspect, the use of two oppositely charged surfactants as the primary emulsifiers in two separated parts of a product. The emulsifiers are chosen such that when the two parts of the emulsion product are mixed, the emulsifiers react to form water insoluble compounds that are no longer able to function as emulsifiers, thus, the oil phase of the emulsion is precipitated onto the skin along with the emulsifier reaction product. Since none of the deposited materials are water soluble, or capable of functioning as emulsifiers, the deposited oil phase is extremely resistant to being washed off. This technology finds applications in hand and body creams and lotions, baby care products, sunscreens, skin protective products, makeup systems, and automotive and furniture polishes.

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Номер записи: 34
08-03-2012 дата публикации

Activated leukocyte composition and uses for wound healing

Номер: US20120058156A1
Автор: Adi Zuloff-Shani, Eilat Bain, Eilat Shinar, Irene Ginis, Marina Bubis, Mitchell Shirvan, Orit Frenkel
Принадлежит: Macrocure Ltd

Disclosed are therapeutic, blood-derived activated leukocyte compositions, methods of making them, and methods of using the compositions to repair or promote the prevention and healing of wounds.

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Номер записи: 35
08-03-2012 дата публикации

Cleaning or cosmetic compositions comprising natural zeolites

Номер: US20120058164A1
Автор: Paul Lap Shun Chan, Philip John Ashenden, Ray John Merchant
Принадлежит: ZEOSOFT Ltd

The invention describes compositions which are useful as cleansers of the skin. The compositions described comprise zeolitic ingredients which are in general softer than known products. The natural zeolitic ingredients are inherently soft. The softness is due to a number of factors including but not limited to younger zeolitic rock types, softer constituent elements, more porous rock types and less dense rock types. The overall softness provided by the compositions according to the invention provides a cleaning product that is softer to the skin, especially the human skin.

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Номер записи: 36
08-03-2012 дата публикации

Compositions, use and method for the use of surface active proteins in topical drug delivery across keratin

Номер: US20120058199A1
Автор: Andreas Buthe, Andreas Hafner, Babette Fiedler, Franz Kaufmann, Gordon Bradley, Guido Meurer
Принадлежит: BASF SE

The present invention provides the use of surface active proteins, especially class I and class II hydrophobins, in topically applied pharmaceutical formulations. The invention is particularly directed to topically applied pharmaceutical products for enhancing the penetration to achieve a transungual delivery of a prophylactically and/or therapeutically effective amount of an active ingredient (drug) to a patient (including animals and humans) into and/or through a nail, of the animal or human body, in order to treat one or more of a variety of diseases or disorders. Related embodiments of the invention are also disclosed.

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Номер записи: 37
08-03-2012 дата публикации

Hmg-coa reductase derived peptide and cosmetic or pharmaceutical composition containing same

Номер: US20120058952A1
Автор: Claude Dal Farra, Jean-Marie Botto, Nouha Domloge
Принадлежит: ISP Investments LLC

The present invention relates to a peptide of general formula (I): R 1 -(AA) n -X 1 -Gly-Glu-Leu-Ser-X 2 -X 3- (AA) p -R 2 , derived from human HMG-CoA reductase. The present invention also relates to a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a physiologically suitable medium. The present invention further relates to the use of this novel peptide as an active principle that activates human HMG-CoA reductase in a cosmetic composition intended to strengthen the barrier function of the skin and to stimulate epidermal differentiation. The invention further applies to a cosmetic treatment method intended to prevent and/or combat the external stresses and signs of cutaneous aging.

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Номер записи: 38
08-03-2012 дата публикации

Methods and compositions for modification of a hla locus

Номер: US20120060230A1
Автор: Andreas Reik, Edward J. Rebar, Fyodor Urnov, Jeffrey C. Miller, Laurence J.N. Cooper, Michael C. Holmes, Philip D. Gregory, Trevor Collingwood
Принадлежит: Individual

Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.

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Номер записи: 39
15-03-2012 дата публикации

Absorbable adhesive paste

Номер: US20120064027A1
Автор: Shalaby W. Shalaby
Принадлежит: Poly Med Inc

An absorbable adhesive paste contains absorbable solid carboxy-bearing microparticles dispersed in a continuous phase of an alkoxyalkyl cyanoacrylate. The paste may contain a soluble absorbable polymeric viscosity modifier and at least one bioactive agent to maximize the effective application as a cover for compromised tissues and wounds or as sealants, blocking agents, or hemostatic agents.

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Номер записи: 40
15-03-2012 дата публикации

Il-17 homologous polypeptides and therapeutic uses thereof

Номер: US20120064073A1
Автор: Audrey Goddard, Austin L. Gurney, Colin K. Watanabe, Daniel G. Yansura, Daniel Tumas, Dorothy French, Ellen Fllvaroff, Hanzhong Li, J. Christopher Grimaldi, James Pan, Jian Chen, Kenneth J. Hillan, Melissa A. Starovasnik, Menno Van Lookeren, P. Mickey Williams, Paul J. Godowski, Richard Vandlen, Sarah G. Hymowitz, Sherman Fong, William I. Wood
Принадлежит: Individual

The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

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Номер записи: 41
15-03-2012 дата публикации

Novel Target for Regulating Multiple Sclerosis

Номер: US20120064092A1
Автор: Brian A. Zabel, Eugene C. Butcher, Kareem Graham
Принадлежит: Leland Stanford Junior University, US Department of Veterans Affairs VA

Methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). Methods are also provided for screening for agents that find use in treating demyelinating inflammatory disease in a subject.

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Номер записи: 42
15-03-2012 дата публикации

Enhanced Binding of Pro-Inflammatory Cytokines by Polysaccharide-Antibody Conjugates

Номер: US20120064097A1
Автор: Liang Tso Sun, Newell R. Washburn
Принадлежит: WASHBURN THERAPEUTICS Inc

We provide monoclonal antibodies against interleukin-1β and tumor necrosis factor-α that remain biologically active in vitro when conjugated to high molecular weight polysaccharides. We report enhanced binding of these cytokines when their monoclonal antibodies are conjugated to alginate compared to non-conjugated monoclonal antibodies. In cell assays, polysaccharide-antibody constructs of the invention inhibited cytokine signaling to comparable levels as that of unmodified antibodies. Conjugation of cytokine-neutralizing antibodies to high molecular weight polymers enhances the affinities cytokine-binding moieties used as anti-inflammatory therapeutics.

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Номер записи: 43
15-03-2012 дата публикации

Biocompatible materials containing stable complexes of tsg-6 and hyaluronan and method of using same

Номер: US20120064150A1
Автор: Hans-Georg Wisniewski, Mary K. COWMAN, Philip Band
Принадлежит: Polytechnic Institute of NYU

The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable comples of TNF-stimulated gene 6 protein (TSG-6) and hyaluronan.

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Номер записи: 44
15-03-2012 дата публикации

Cosmetic or dermatological preparation comprising collagen, chitosan, glycosylaminoglycan and cell growth promoting peptide and/or cellular complex

Номер: US20120064182A1
Автор: Daniel Stangl, Sven Gohla
Принадлежит: Beiersdorf AG

A cosmetic or dermatological preparation that is obtainable by combining collagen and/or a derivative thereof, chitosan and/or a derivative thereof, glycosylaminoglycan and/or a derivative thereof with a peptide which is capable of promoting skin cell growth and/or with a composition which comprises glycoproteins 1 and 2 and ginseng and horsetail extracts.

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Номер записи: 45
15-03-2012 дата публикации

Peptide for the Prophylactic or Therapeutic Treatment of Skin Tumors in Initial Stages

Номер: US20120065144A1
Автор: Javier Dotor De Las Herrerias, Miguel Quintanilla Avila, Raúl INSA BORONAT
Принадлежит: Isdin Sa

It comprises an inhibitor peptide of TGF-β1 for use in preventive or therapeutic treatment of skin tumors at early stages, in which the peptide is disitertide or a derivate thereof, and a pharmaceutical composition that comprises a therapeutically effective amount of the peptide.

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Номер записи: 46
15-03-2012 дата публикации

Dual targeting antibody of novel form, and use thereof

Номер: US20120065380A1
Автор: Jin San Yoo, Sang Ryeol Shim, Sung Woo Kim, Weon Sup Lee
Принадлежит: Pharmabcine Inc

The present invention relates to: a dual targeting antibody of a novel form having a water-soluble ligand fused to the N-terminus of a heavy chain or light chain of an antibody; a DNA encoding the dual targeting antibody; a recombinant expression vector containing the DNA; a host cell which is transformed with the recombinant expression vector; a method for preparing the dual targeting antibody by culturing the host cell; and a pharmaceutical composition including the dual targeting antibody.

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Номер записи: 47
22-03-2012 дата публикации

Extracellular yaluronidase from streptomyces koganeiensis

Номер: US20120070441A1
Автор: Giovanni Gennari, Luciano Messina, Salvatore Caruso, Susana Vaccaro
Принадлежит: KETER PLASTIC LTD

The invention relates to Streptomyces koganeiensis ATCC 31394 hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date. The invention further relates to a process for the isolation and purification of said hyaluronidase and its use for the preparation of pharmaceutical compositions or as an analytical reagent.

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Номер записи: 48
22-03-2012 дата публикации

Method of extraction from withania somnifera and one or more fractions containing pharmacologically active ingredients obtained therefrom

Номер: US20120070521A1
Автор: Debendranath Dey, Deepa Chitre, Sachin Chaturvedi, Sunetra Chaskar
Принадлежит: Bio Ved Pharmaceuticals PVT Ltd

A method of obtaining one or more fractions from a plant material of Withania somnifera (WS) is disclosed. The method includes subjecting the plant material to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain at least one extract. The method further includes subjecting the at least one extract obtained from the hydro-alcoholic extraction to at least one of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain Withaferin A in a concentration greater than concentrations of other pharmacologically active ingredients present in the one or more fractions. The one or more fraction thus obtained and one or more compositions containing the one or more fractions are effective in inhibiting proliferation of mammalian cancerous cells.

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Номер записи: 49
29-03-2012 дата публикации

Post-biopsy cavity treatment implants and methods

Номер: US20120076733A1
Автор: Ary S. Chernomorsky, James W. Vetter, Simon Chernomorsky
Принадлежит: Chernomorsky Ary S, Simon Chernomorsky, VETTER JAMES W

A post-biopsy cavity treatment implant includes a radiopaque element, a core portion and a shell portion. The core portion is coupled to the radiopaque element, and includes a first porous matrix defining a first controlled pore architecture. The shell portion is coupled to the core portion and includes a second porous matrix defining a second controlled pore architecture that is different from the first controlled pore architecture.

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Номер записи: 50
29-03-2012 дата публикации

Modified green tea polyphenol formulations

Номер: US20120076872A1
Автор: Stephen D. Hsu
Принадлежит: Georgia Health Sciences University Research Institute Inc

Modified green tea polyphenols and methods of their use are provided. One aspect provides compounds and compositions containing green tea polyphenols with one on more ester-linked fatty acids.

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Номер записи: 51
29-03-2012 дата публикации

Hydrophilic polyproylene melt additives

Номер: US20120077886A1
Автор: Matthew T. Scholz, Michael R. Berrigan, Thomas P. Klun
Принадлежит: 3M Innovative Properties Co

Melt additive ionic and non-ionic surfactants to impart stable durable hydrophilicity to thermoplastic polymers or blends thereof.

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Номер записи: 52
29-03-2012 дата публикации

Terpolymers as pressure-sensitive adhesives

Номер: US20120077887A1
Автор: Bruce W. Hudson, Howard Bowman
Принадлежит: Surmodics Pharmaceuticals Inc

Disclosed herein are terpolymers that can function as pressure-sensitive adhesives. The disclosed articles comprise the terpolymers adhered to a release liner. The disclosed implant devices comprise the pressure-sensitive adhesive terpolymer adhered to a surface thereof. The pressure-sensitive adhesive terpolymer can promote adhesion of the implant device to a location in a subject.

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Номер записи: 53
05-04-2012 дата публикации

Human cytokine receptor

Номер: US20120082673A1
Автор: Scott R. Presnell, Steven D. Hughes, Wayne R. Kindsvogel, Wenfeng Xu, Zhi Chen
Принадлежит: Zymogenetics Inc

Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”

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Номер записи: 54
05-04-2012 дата публикации

Methods for preventing and treating angioedema

Номер: US20120082676A1
Автор: Berhane Ghebrehiwet
Принадлежит: Research Foundation of State University of New York

One aspect of the present invention provides a method of treating or preventing angioedema in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R. One aspect of the present invention provides a method of treating or preventing vascular permeability in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R.

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Номер записи: 55
05-04-2012 дата публикации

Anti-il12rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders

Номер: US20120082681A1
Автор: Andrea Polzer, Christoph Heusser, Christoph Schwaerzler, Gabriela Wochnik-Veltrup, Ingo Klagge, José M. Carballido Herrera, Stefan Hartle
Принадлежит: NOVARTIS AG

The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of both the heterodimeric IL12 and IL23 receptors. The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/1L18 induced IFNγ production of blood cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNγ production, IL12 and/IL23 signaling, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.

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Номер записи: 56
05-04-2012 дата публикации

Compositions Containing HC-HA Complex and Methods of Use Thereof

Номер: US20120083445A1
Автор: Hua He, Scheffer Tseng
Принадлежит: TissueTech Inc

Disclosed herein, in certain embodiments, is an HC•HA complex comprising hyaluronan and a heavy chain of IαI, wherein the transfer of the heavy chain of IαI is catalyzed by TSG-6. Further disclosed herein, in certain embodiments, is an HC•HA complex comprising hyaluronan and a heavy chain of IαI, wherein the transfer of the heavy chain of IαI is catalyzed by the TSG-6 like protein. Additionally, disclosed herein are methods of manufacturing said complex and methods of use thereof

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Номер записи: 57
05-04-2012 дата публикации

Pharmaceutical composition for promoting the healing of wounds and containing lysophosphatidic acid and an adenylyl cyclase inhibitor as active ingredients

Номер: US20120083472A1
Автор: Eui Ju Yeo, Ji Heon Rhim, Sang Chul Park
Принадлежит: SNU R&DB FOUNDATION

The present invention relates to a pharmaceutical composition for promoting the healing of wounds, containing lysophosphatidic acid and an adenylyl cyclase inhibitor as active ingredients, and more particularly, to a pharmaceutical composition which contains an adenylyl cyclase inhibitor and which promotes the healing of wounds in senescent cells or aged persons having physiological characteristics different than those of young cells or young persons. In addition, the present invention relates to a method for promoting the healing of wounds involving treating a wounded person with an effective dose of the lysophosphatidic acid and adenylyl cyclase inhibitor.

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Номер записи: 58
12-04-2012 дата публикации

Hair growth agent having a platelet dry powder

Номер: US20120087903A1
Автор: Chin I Lin, Han-Lei Wan
Принадлежит: Central Medical Technologies Inc

A hair growth agent having an effective dose of a platelet dry powder and a pharmaceutically acceptable solvent and/or excipient, wherein the effective dose refers to the presence of at least 1,000 platelets in every milligram of the hair growth agent.

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Номер записи: 59
12-04-2012 дата публикации

Pinane-substituted pyrimidinediamine derivatives useful as axl inhibitors

Номер: US20120088768A1
Автор: Dane Goff, Pingyu Ding, Rajinder Singh, Sacha Holland
Принадлежит: Rigel Pharmaceuticals Inc

Pinane-substituted pyrimidinediamine derivatives and pharmaceutical compositions containing the derivatives are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the derivatives in treating diseases or conditions associated with Axl catalytic activity are also disclosed.

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Номер записи: 60
19-04-2012 дата публикации

Peptide fragments for inducing synthesis of extracellular matrix proteins

Номер: US20120093740A1
Автор: Lijuan Zhang, Scott M. Harris, Timothy J. Falla
Принадлежит: Helix Biomedix Inc

Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

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Номер записи: 61
19-04-2012 дата публикации

Anti-vegf-d antibodies

Номер: US20120093811A1
Автор: Andrew J. Pow, George Kopsidas, Irene Koukoulas, Jason W. Simmonds, Vincent Emil W. Batori
Принадлежит: Vegenics Pty Ltd

The invention relates to an isolated antibody that specifically binds vascular endothelial growth factor-D (VEGF-D) and to a humanized antibody that specifically binds VEGF-D.

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Номер записи: 62
19-04-2012 дата публикации

Opioid Composition for Treating Skin Lesions

Номер: US20120093929A1
Автор: Alexander Oksche, Bernard Kennedy, Derek Prater, Hassan Mohammad, Kevin J. Smith, Malcolm Walden, Vanessa Addison, Will Heath
Принадлежит: Euro Celtique SA

The present invention relates to a composition, comprising (i) a matrix made of polymeric nanofibers, and (ii) an opioid agonist within the matrix.

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Номер записи: 63
26-04-2012 дата публикации

Humanized antibodies against light and uses thereof

Номер: US20120100074A1
Автор: Bridget A. Cooksey, Craig Rosen, Palanisamy Kanakaraj, Rodger Smith, Viktor Roschke
Принадлежит: Teva Biopharmaceuticals USA Inc

The present invention is directed to antigen-binding polypeptides, or variants or derivatives thereof which specifically bind the LIGHT polypeptide. The invention is also directed to methods of making and using such antibodies specifically in the treatment or diagnosis of immune, inflammatory and malignant diseases or conditions (e.g. inflammatory bowel disease; Crohn's disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis and transplantation).

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Номер записи: 64
26-04-2012 дата публикации

In vivo transfer methods for wound healing

Номер: US20120100107A1
Автор: Jeffrey Bonadio, Steven A. Goldstein
Принадлежит: University of Michigan

The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.

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Номер записи: 65
26-04-2012 дата публикации

CD86 Antagonist Multi-Target Binding Proteins

Номер: US20120100139A1
Автор: John W. Blankenship, Peter Armstrong Thompson, Peter Robert Baum, Philip Tan, Sateesh Kumar Natarajan
Принадлежит: Emergent Product Development Seattle LLC

This disclosure provides a multi-specific fusion protein composed of a CD86 antagonist binding domain and another binding domain that is an IL-10 agonist, an HLA-G agonist, an HGF agonist, an IL-35 agonist, a PD-1 agonist, a BTLA agonist, a LIGHT antagonist, a GITRL antagonist or a CD40 antagonist. The multi-specific fusion protein may also include an intervening domain that separates the other domains. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.

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Номер записи: 66
26-04-2012 дата публикации

Novel cellular factor-containing solution compositions

Номер: US20120101036A1
Автор: Catherine J. Trumpower, Charlotte A. Smith, Vivienne S. Marshall
Принадлежит: Stemnion LLC

The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof.

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Номер записи: 67
26-04-2012 дата публикации

Pure isomers of tritoqualine

Номер: US20120101120A1
Автор: Emile Loria, Gaetan Terrasse, Michalis Nicolaou, Yves Trehin
Принадлежит: Individual

The invention provides an isolated stereoisomer of tritoqualine having the structure of FIG. 2 and FIG. 3.

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Номер записи: 68
03-05-2012 дата публикации

Polymers and Hydrogels

Номер: US20120107369A1
Автор: Adrian S. Fox, Guoming Sun, Roy R. Yeoman, III
Принадлежит: nanoDERM LLC

Methods and compositions related polymers and hydrogels. In some cases to biodegradable hydrogels for use in medical applications are disclosed. The polymers and hydrogels may be produced from cross-linked dextran and poly(epoxides). The poly(epoxides) may be poloxamers.

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Номер записи: 69
03-05-2012 дата публикации

Processes for preparing amine salts of sildenafil-analogues and use thereof

Номер: US20120108604A1
Автор: Ing-Jun Chen
Принадлежит: KAOHSIUNG MEDICAL UNIVERSITY

A series of amine salts including a structure of formula (I) and formula (III) have provided. In formula I or formula (III), R 1 , R a and RX are as defined in the specification. The amine complex salts disclosed in the present invention are characterized in a pro-drug active form and various pharmaceutical function.

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Номер записи: 70
10-05-2012 дата публикации

Method for treating immune disorders

Номер: US20120114555A1
Автор: Andrew T. Hutchinson, Darren R. Jones, Parisa Asvadi, Robert L. Raison, Rosanne D. Dunn
Принадлежит: IMMUNE SYSTEM THERAPEUTICS LTD

The present invention relates to the treatment of B-cell mediated immune disorders such as rheumatoid arthritis, systemic lupus erythromatomus, diabetes mellitus, and multiple sclerosis. In particular, the present invention relates to the treatment of B-cell mediated immune disorders using antibodies which bind to membrane-bound free light chain expressed on the surface of plasma cell precursors.

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Номер записи: 71
10-05-2012 дата публикации

Methods for inhibiting cutaneous inflammation and hyperpigmentation

Номер: US20120114575A1
Автор: B. Jack Longley
Принадлежит: Columbia University of New York

This invention provides a method of preventing or treating in a subject contact dermatitis which comprises administering to the subject an amount of a compound capable of inhibiting the stem cell factor signaling pathway effective to prevent or treating contact dermatitis so as to thereby prevent or treat contact dermatitis in the subject. This invention also provides a method of preventing or treating in a subject hyperpigmentation, asthma, cutaneous inflammation, anaphylaxis and bronchospasm, mastocytosis, tumors which express activated kit, and conception.

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Номер записи: 72
10-05-2012 дата публикации

Cosmetic and therapeutic use of proteins of dj-1 type for treating skin dryness

Номер: US20120114628A1
Автор: Dominique Bernard, Isabelle Castiel, Lucie Simonetti
Принадлежит: LOreal SA

The present invention relates to the use, especially the cosmetic and/or therapeutic use, of the protein DJ-1, of polypeptides derived from this protein or of analogues thereof, of a nucleic acid sequence coding for such a polypeptide or of a modulator of the activity, stability or expression of such a polypeptide, especially for preventing and/or treating the signs of skin dryness. The invention also relates to the use of the protein DJ-1, of polypeptides derived from this protein or of analogues thereof or of a nucleic acid sequence coding for such a polypeptide, as a marker for evaluating the state of dryness of an epithelium.

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Номер записи: 73
10-05-2012 дата публикации

Variants of plasminogen and plasmin

Номер: US20120114630A1
Автор: Richard Reinier Zwaal
Принадлежит: THROMBOGENICS NV

The invention relates to variants of plasminogen and plasmin comprising one or more point mutations in the catalytic domain which reduce or prevent autocatylic destruction of the protease activity of plasmin. Compositions, uses and methods of using said variants of plasminogen and plasmin are also disclosed.

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Номер записи: 74
10-05-2012 дата публикации

Use of total coumarins of cnidium fruit in preparing medicaments for treating psoriasis

Номер: US20120115940A1
Автор: Liping Yang
Принадлежит: Individual

A pharmaceutic composition for treating psoriasis. Ii has an active component and a carrier. The active component has a major active ingredient osthol and a group of minor active ingredients: xanthotoxol, xanthotoxin, isopimpinellin, bergapten, and imperatorine. The major active ingredient osthol accounts for at least 90% by weight of the active component, which accounts for 5-35% by weight of the overall pharmaceutic composition.

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Номер записи: 75
10-05-2012 дата публикации

Combination/association of adapalene and benzoyl peroxide for treating acne lesions

Номер: US20120115947A1
Автор: Christian Loesche, Denis Gross, Marie-Line Abou Chacra Vernet, Michel Poncet
Принадлежит: Galderma Research and Development SNC

Acne lesions, whether of inflammatory and/or non-inflammatory type, are simultaneously or sequentially treated and their number reduced, via daily topical regimen, with the combination or association of adapalene or pharmaceutically acceptable salt thereof and benzoyl peroxide (BPO).

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Номер записи: 76
17-05-2012 дата публикации

Localized therapy following breast cancer surgery

Номер: US20120121510A1
Автор: Daniel S. Kohane, Rachel F. Brem, Robert S. Langer
Принадлежит: Individual

Particles providing prolonged release of chemotherapy are injected or implanted into surgical sites in the breast following removal of cancerous tissue. In one embodiment, the particles are designed to not release formulation for approximately two to three weeks after surgery so as to not inhibit healing; in another embodiment particles are not administered until two to three weeks after surgery, and release immediately. The particles then release an effective amount of a chemotherapeutic such as a taxane to inhibit proliferation of any remaining cancer cells at or near the surgical site. This may also help prevent overproliferation leading to scarring with the surgical region.

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Номер записи: 77
17-05-2012 дата публикации

Nucleic acid ligands to ll37

Номер: US20120121533A1
Автор: George W. Jackson
Принадлежит: Biotex Inc

The present invention is directed to nucleic acid ligands to LL37, methods for producing said nucleic acid ligands, and methods for utilizing said nucleic acid ligands. In one exemplary embodiment, for example, this invention relates to nucleic acid ligands exhibiting high specific binding affinity to LL37 peptides, precursors and/or portions thereof. Further, the nucleic acid ligands may bind competitively with native ligands of LL37 and may also inhibit and/or interfere with LL37 function, such as by binding to LL37.

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Номер записи: 78
17-05-2012 дата публикации

Cellular electric stimulation mediated by piezoelectric nanotubes

Номер: US20120121712A1
Автор: Alfred Cuschieri, Arianna Menciassi, Gianni Ciofani, Mario PETRINI, Paolo Dario, Serena Danti, Vittoria Raffa
Принадлежит: Individual

Piezoelectric nanotransducers for use in an in vivo treatment of cell stimulation through electrical stimulation are described. The nanotransducers are localized in a target site, and an electrical stimulus is induced in the same site through external stimulation of the nanotransducers by ultrasonic waves.

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Номер записи: 79
17-05-2012 дата публикации

Skin care products and compositions

Номер: US20120121721A1
Автор: Michael James
Принадлежит: Individual

Disclosed herein is a composition for treating maladies in humans or animals that includes from about 0.01% to about 40% by weight of a member of the curcuma genus, from about 0.01% to about 40% by weight of a member of the coffea genus and the balance being a pharmaceutically acceptable carrier.

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Номер записи: 80
17-05-2012 дата публикации

Compounds, Compositions and Methods for Modulating Uric Acid Levels

Номер: US20120122780A1
Автор: Jean-Luc Girardet, Martha De La Rosa
Принадлежит: Ardea Biociences Inc

Described herein are compounds useful in the reduction of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.

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Номер записи: 81
17-05-2012 дата публикации

Topical pharmaceutical composition including rel-n-[6-[(2r,6s)-2,6-dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide

Номер: US20120122866A1
Автор: Andreas Fritze, Karine Corcelle, Melinda Eniko Grubesa
Принадлежит: NOVARTIS AG

The present invention relates to pharmaceutical compositions of 2-Methyl-4′-trifluoromethoxy-biphenyl-3-carboxylic acid [6-(cis-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-amide, to the use of such compositions in therapeutic applications and to methods for manufacturing such compositions.

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Номер записи: 82
24-05-2012 дата публикации

Il-17 homologous polypeptides and therapeutic uses thereof

Номер: US20120128627A1
Автор: Audrey Goddard, Austin Gurney, Ellen Filvaroff, Hanzhong Li, Jian Chen, William I. Wood
Принадлежит: Individual

The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

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Номер записи: 83
24-05-2012 дата публикации

Modified hyaluronic acid polymer compositions and related methods

Номер: US20120128741A1
Автор: David M. Gravett, George Y. Daniloff, Pingren He
Принадлежит: Carbylan Biosurgery Inc

The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.

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Номер записи: 84
24-05-2012 дата публикации

Skin Permeating And Cell Entering (SPACE) Peptides and Methods of Use Thereof

Номер: US20120128756A1
Автор: Samir M. Mitragotri, Tracy Hsu
Принадлежит: UNIVERSITY OF CALIFORNIA

The present disclosure provides peptides and peptide compositions, which facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells.

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Номер записи: 85
24-05-2012 дата публикации

Composition containing bee venom as an active ingredient for preventing and treating acne

Номер: US20120128784A1
Автор: Chung Sub Han, Ju Hong Yeo, Kwang Gil Lee, Sang Mi Han, Yang Gu Lee
Принадлежит: Dong Sung Pharmaceuticals Co Ltd, Korea Rural Development Administration

The present invention relates to a composition for preventing and treating acne, comprising a material which has excellent antibacterial activity against Propionibacterium acnes known as acne-causing bacteria and which shows strong antibacterial activity against skin floras that enlarge the site of inflammation to worsen acne, in which the material also helps to regenerate skin cells damaged by acne. The composition comprises bee venom (collected from Apis meliffera ) and is used the form of soap, cosmetic products, and medical products for skin application such as ointments, bands and dressings, which are used to fundamentally prevent and treat acne.

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Номер записи: 86
24-05-2012 дата публикации

Methods and compositions for diagnosing ankylosing spondylitis using biomarkers

Номер: US20120129185A1
Автор: Robert L. Wong, Walter P. Maksymowych
Принадлежит: Abbott Biotech Ltd Bermuda

The invention provides a method for determining the efficacy of a TNFα inhibitor, such as a TNFα antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS), using a collagen degradation biomarker and/or a synovitis biomarker.

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Номер записи: 87
24-05-2012 дата публикации

Clay-based hemostatic agents and devices for the delivery thereof

Номер: US20120130296A1
Автор: Daniel J. Burns, Denny Lo, Francis X. Hursey, Giacomo Basadonna, Raymond J. Huey
Принадлежит: Z Medica LLC

A hemostatic device for promoting the dotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.

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Номер записи: 88
24-05-2012 дата публикации

Detection and treatment of autoimmune disorders

Номер: US20120130350A1
Автор: Anne M. Stevens, Neelufar Mozaffarian
Принадлежит: Seattle Childrens Hospital

Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand.

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Номер записи: 89
31-05-2012 дата публикации

Whitening Agent And Skin External Preparation

Номер: US20120134944A1
Автор: Kimihiro Ogino, Kiyoshi Sato, Naoto Hanyu, Takako Shibata, Tomoko Saito
Принадлежит: Shiseido Co Ltd

The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a heterocyclic compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein R 1 , R 2 , and R 2 ′ are each independently C 1-3 alkyl; Y is S or O; and p is an integer of 0 to 3, wherein when p is 2 or 3, R 1 may be the same or different.

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Номер записи: 90
31-05-2012 дата публикации

Topical Gels and Methods of Using the Same

Номер: US20120134951A1
Автор: Nathan Stasko, Pranav R. Joshi, Susanne Bauman
Принадлежит: Individual

Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments. The topical gels comprise diazeniutndiolate-functionalized polysiloxane macromolecules.

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Номер записи: 91
31-05-2012 дата публикации

Compounds and methods for skin repair

Номер: US20120136011A1
Автор: Frederick C. Beddingfield, Guang L. Jiang, Larry A. Wheeler, Robert M. Burk, Scott M. Whitcup, Wha-Bin Im
Принадлежит: Allergan Inc

The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles.

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Номер записи: 92
31-05-2012 дата публикации

Materials and methods for measuring nitric oxide levels in biological fluids

Номер: US20120136054A1
Автор: Daniel J. Gibson, Gregory S. Schultz
Принадлежит: University of Florida Research Foundation Inc

The subject invention presides novel devices and methods for the measurement of nitric oxide in biological samples, including wound fluid samples. These advantageous devices and methods can be used for clinicians to monitor the wound's nitric oxide metabolism and/or response to treatment.

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Номер записи: 93
31-05-2012 дата публикации

Medicinal Cream For Diaper Rash And A Process To Make It

Номер: US20120136071A1
Автор: Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Vanangamudi Subramaniam Sulur
Принадлежит: Apex Labs Private Ltd

The present invention relates to a composition for treating diaper rash along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an anti diaper rash active ingredient. It discloses a composition for treating diaper rash along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active ingredients used in treating diaper rash, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, and diaper rash agents, are incorporated in cream base for use in treating diaper rash.

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Номер записи: 94
31-05-2012 дата публикации

Pyridinyl Compounds Useful As Intermediates

Номер: US20120136158A1
Автор: Alan David Swinamer, Brian Christopher Raudenbush, Brian Nicholas Cook, Can Mao, Christian Harcken, Daniel Kuzmich, Daniel Robert Fandrick, Darren DiSalvo, Hossein Razavi, Jinhua J. Song, Jochen Neu, John Lord, Jonathan Timothy Reeves, Pingrong Liu, Thomas Wai-Ho Lee, Zhulin Tan
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.

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Номер записи: 95
07-06-2012 дата публикации

Composition including an unsaponifiable fraction

Номер: US20120141387A1
Автор: David Daguet, Philippe Msika
Принадлежит: Laboratoires Expanscience SA

The present invention relates to a composition, notably cosmetic, nutraceutical, dermatological, pharmaceutical or dietary, including at least one unsaponif iable extract, a drug including one such composition, the use of one such composition, a treatment method consisting in administering one such composition and a method comprising the administration of one such composition.

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Номер записи: 96
07-06-2012 дата публикации

Skin lightening composition for hyperpigmented skin

Номер: US20120141397A1
Автор: Bomi Patel Framroze
Принадлежит: Romano Dev Inc

An improved skin composition intended for topical application to skin for lightening hyperpigmented skin is provided. The subject composition is characterized by incorporation of at least one carbohydrate-based melanin inhibiting agent selected from bearberry extract, ascorbyl glucoside, rutin and arbutin into an ultra low molecular weight aminoglycan polymer gel. It has been found that the skin composition of the present invention possesses improved skin penetration and significantly enhances the depigmenting effect of the active agents.

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Номер записи: 97
07-06-2012 дата публикации

Treatment of Melanoma Using HSV Mutant

Номер: US20120141418A1
Автор: Alasdair Roderick MacLean, Bruce Paul Randazzo, Nigel William Fraser, Susanne Moira Brown
Принадлежит: Virttu Biologics Ltd, Wistar Institute of Anatomy and Biology

Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the γ34.5 gene in the long repeat region (R L ) such that the γ34.5 gene is a non-functional, manufacture of medicaments and methods of testing cancer in mammals employing HSV mutant.

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Номер записи: 98
07-06-2012 дата публикации

Methods for treating inflammation using b7-h4 polypeptides and fragments thereof

Номер: US20120141504A1
Автор: Lieping Chen
Принадлежит: Mayo Foundation for Medical Education and Research

The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.

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Номер записи: 99
07-06-2012 дата публикации

Umbilical cord amniotic membrane products

Номер: US20120141595A1
Автор: Amy Tseng, Ek Kia Tan, Scheffer Tseng
Принадлежит: TissueTech Inc

Disclosed herein, in certain instances, are tissue grafts derived from UCAM. Further disclosed herein, in certain instances, are use for tissue grafts derived from UCAM.

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Номер записи: 100