Поиск патентов

05-01-2012 дата публикации

Dpp iv inhibitor formulations

Номер: US20120003313A1

Автор: Anja Kohlrausch, Gerd Seiffert, Patrick Romer

Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

The present invention relates to pharmaceutical compositions of DPP IV inhibitors with an amino group, their preparation and their use to treat diabetes mellitus.

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Номер записи: 1

05-01-2012 дата публикации

Formulation Comprising Bioactive Agents And Method Of Using Same

Номер: US20120004170A1

Автор: Daniel Schwartz, Susan J. Sofia, Wolfgang Friess

Принадлежит: Friedrich Alexander Univeritaet Erlangen Nuernberg FAU

Disclosed are methods of making bioactive BMP-2 microparticles and methods of using the microparticles.

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Номер записи: 2

05-01-2012 дата публикации

Salt of cd 80 antagonist

Номер: US20120004237A1

Автор: Richard Ian MATTHEWS

Принадлежит: MEDIGENE AG

Choline salt of the CD80 antagonist compound 4-(6-fluoro-3-oxo-1,3-dihydro-pyrazolo[4,3-c]cinnolin-2-yl)-N-(2,2-difluoro-ethyl)-benzamide.

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Номер записи: 3

19-01-2012 дата публикации

Estrogen receptors and methods of use

Номер: US20120016109A1

Автор: Zhao Yi Wang

Принадлежит: CREIGHTON UNIVERSITY

The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has ER-α36 activity. The invention further provides methods for identifying agents that bind to such polypeptides, methods for detecting such polypeptides, and methods for altering the activity of such polypeptides. Also provided are antibodies that specifically bind to an amino acid sequence depicted at SEQ ID NO:1, or an immunogenic fragment thereof, and methods for making and using such antibodies.

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Номер записи: 4

02-02-2012 дата публикации

Bisphosphonate product in a cycloolefinic polymer container

Номер: US20120027818A1

Автор: Alexandra Glausch, Juergen Sigg, Rolf Loeffler

Принадлежит: Individual

A pharmaceutical product comprises a container containing a bisphosphonate solution, in which at least the internal surface of the container comprises a plastic material and in which the container is heat sterilisable, and which is in the form of an infusion solution preconcentrate for administration of the bisphosphonate to a patient in need of bisphosphonate treatment.

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Номер записи: 5

02-02-2012 дата публикации

Clonidine for treatment of bone cancer

Номер: US20120029042A1

Автор: Vanja Margareta King

Принадлежит: WARSAW ORTHOPEDIC INC

The present invention is directed to a method for treating osteolytic bone cancer. The method comprises implanting a drug depot locally at or near the osteolytic bone cancer, wherein the drug depot comprises at least one biodegradable polymer and clonidine in an amount from about 0.1 wt. % to about 30 wt. % of the drug depot.

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Номер записи: 6

02-02-2012 дата публикации

Novel Crystalline Form of Atorvastatin Hemi-calcium Salt, Hydrate Thereof, And Method of Producing The Same

Номер: US20120029207A1

Автор: Do Yeon Oh, Doo Seong Choi, Hoe Joo Son, Kyung Ju Lee, Sun Ho Chang

Принадлежит: KYONGBO PHARM

The present invention provides a novel crystalline form of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-mthylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptanoic acid hemi-calcium salt (atorvastatin hemi-calcium salt) of the following formula 1, which is known to be useful as a drug, a hydrate thereof and a preparation method thereof:

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Номер записи: 7

16-02-2012 дата публикации

Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use

Номер: US20120039980A1

Автор: David M. Gravett, George Y. Daniloff, Jacqueline Schroeder, Louis C. Sehl, Olof Mikael Trollsas, Philip M. Toleikis

Принадлежит: AngioDevice International GmbH

Methods of preventing adhesion between issues are provided that utilizes in situ crosslinked biomaterials. The biomaterial contains at least the crosslinked product of two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Exemplary uses for the crosslinked compositions include preventing adhesions following surgery or injury, and preventing scar tissue formation.

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Номер записи: 8

16-02-2012 дата публикации

Collagen peptide composition having good ability to enter the blood and food or beverage containing the same

Номер: US20120040055A1

Автор: Hidetoshi Nishizawa, Hiroki Ohara, Hitoshi Matsumoto, Koichi Terauchi, Masataka Hata

Принадлежит: Meiji Co Ltd

An object of the present invention is to elucidate a collagen peptide effective for causing dipeptides or tripeptides serving as the active component to enter the blood, and thus to reduce the required intake thereof. According to the present invention, a collagen peptide composition obtained by digesting collagen or gelatin with protease is provided, wherein: (a) the ratio of hydroxyproline to total of amino acid residues at the second position from the N terminus of the peptides in the composition is 2 mol % or more and 20 mol % or less, and the ratio of glycine to total of amino acid residues at the third position from the N terminus of the peptides in the composition is 20 mol % or more and 50 mol % or less; and (b) the average molecular weight is 500 or more and 2000 or less.

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Номер записи: 9

23-02-2012 дата публикации

Methods and uses of hypoxic compartment cells

Номер: US20120045419A1

Автор: Michael George Fehlings, Robert Davies Inman, William Mark Erwin

Принадлежит: UNIVERSITY HEALTH NETWORK

The disclosure relates to methods of maintaining and/or expanding an in vitro population of hypoxia compartment cells comprising culturing said population of cells optionally in an oxygen controlled environment, wherein the population of hypoxia compartment cells is exposed to an oxygen concentration of between about 1.5% and about 10%, preferably between about 2% and about 5%, and uses of cells expanded according to these methods.

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Номер записи: 10

08-03-2012 дата публикации

method for promoting bone growth using activin-actriia antagonists

Номер: US20120058115A1

Автор: Jasbir Seehra, John Knopf

Принадлежит: Acceleron Pharma Inc

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.

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Номер записи: 11

08-03-2012 дата публикации

METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-203

Номер: US20120058914A1

Автор: Aaron J. Schetter, Carlo M. Croce, Curtis C. Harris

Принадлежит: Ohio State University Research Foundation, US Department of Health and Human Services

The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.

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Номер записи: 12

08-03-2012 дата публикации

Phosphonate Compounds

Номер: US20120058975A1

Автор: Ganesh D. Kini, James R. Beadle, Karl Y. Hostetler

Принадлежит: UNIVERSITY OF CALIFORNIA

The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.

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Номер записи: 13

15-03-2012 дата публикации

Il-17 homologous polypeptides and therapeutic uses thereof

Номер: US20120064073A1

Автор: Audrey Goddard, Austin L. Gurney, Colin K. Watanabe, Daniel G. Yansura, Daniel Tumas, Dorothy French, Ellen Fllvaroff, Hanzhong Li, J. Christopher Grimaldi, James Pan, Jian Chen, Kenneth J. Hillan, Melissa A. Starovasnik, Menno Van Lookeren, P. Mickey Williams, Paul J. Godowski, Richard Vandlen, Sarah G. Hymowitz, Sherman Fong, William I. Wood

Принадлежит: Individual

The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

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Номер записи: 14

15-03-2012 дата публикации

Methods of Diagnosing Hypophosphatemic Disorders

Номер: US20120064544A1

Автор: Ken White, Michael Econs, Thomas Meitinger, Tim Matthias Strom

Принадлежит: Indiana University Research And Technology Corp, Ludwig Maximilians Universitaet Muenchen LMU

The present invention relates to methods of diagnosing hypophosphatemic disorders.

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Номер записи: 15

15-03-2012 дата публикации

Crystalline forms of the di-sodium salt of n-(5-chlorosalicyloyl)-8-aminocaprylic acid

Номер: US20120065128A1

Автор: Doris C. O'Toole, JoAnne P. Corvino, Nikhil Dhoot, Shingai Majuru, Steven Dinh, William Elliott Bay

Принадлежит: Emisphere Technologies Inc

The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.

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Номер записи: 16

15-03-2012 дата публикации

Isoform nell-1 peptide

Номер: US20120065574A1

Автор: Chia Soo, Kang Ting

Принадлежит: UNIVERSITY OF CALIFORNIA

This application generally relates to an isoform Nell-1 peptide, compositions thereof, and methods of using the same.

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Номер записи: 17

15-03-2012 дата публикации

Identification of a jak2 mutation involved in vaquez polyglobulia

Номер: US20120066776A1

Автор: Chloe James, Jean-Pierre Le Couedic, Nicole Casadevall, Valerie Ugo, William Vainchenker

Принадлежит: Assistance Publique Hopitaux de Paris APHP, IGR&D SA, Institut National de la Sante et de la Recherche Medicale INSERM

The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.

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Номер записи: 18

29-03-2012 дата публикации

Terpolymers as pressure-sensitive adhesives

Номер: US20120077887A1

Автор: Bruce W. Hudson, Howard Bowman

Принадлежит: Surmodics Pharmaceuticals Inc

Disclosed herein are terpolymers that can function as pressure-sensitive adhesives. The disclosed articles comprise the terpolymers adhered to a release liner. The disclosed implant devices comprise the pressure-sensitive adhesive terpolymer adhered to a surface thereof. The pressure-sensitive adhesive terpolymer can promote adhesion of the implant device to a location in a subject.

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Номер записи: 19

26-04-2012 дата публикации

CD86 Antagonist Multi-Target Binding Proteins

Номер: US20120100139A1

Автор: John W. Blankenship, Peter Armstrong Thompson, Peter Robert Baum, Philip Tan, Sateesh Kumar Natarajan

Принадлежит: Emergent Product Development Seattle LLC

This disclosure provides a multi-specific fusion protein composed of a CD86 antagonist binding domain and another binding domain that is an IL-10 agonist, an HLA-G agonist, an HGF agonist, an IL-35 agonist, a PD-1 agonist, a BTLA agonist, a LIGHT antagonist, a GITRL antagonist or a CD40 antagonist. The multi-specific fusion protein may also include an intervening domain that separates the other domains. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.

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Номер записи: 20

26-04-2012 дата публикации

Osteoinductive bone graft injectable cement

Номер: US20120100225A1

Автор: William F. Mckay

Принадлежит: WARSAW ORTHOPEDIC INC

Osteoconductive bone graft materials are provided. These compositions contain injectable cements and demineralized bone matrix fibers. The combination of these materials enables the filling of a bone void while balancing strength and resorption.

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Номер записи: 21

03-05-2012 дата публикации

Compositions and methods for modifying cell surface glycans

Номер: US20120107281A1

Автор: Robert Sackstein

Принадлежит: Individual

Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.

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Номер записи: 22

03-05-2012 дата публикации

Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same

Номер: US20120107383A1

Автор: William F. Mckay

Принадлежит: WARSAW ORTHOPEDIC INC

Osteoconductive matrices and methods are provided that have one or more statins disposed in calcium phosphate particles. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustained release of the statin and facilitate bone formation and repair of the fracture site.

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Номер записи: 23

03-05-2012 дата публикации

Osteoconductive matrices comprising statins and methods of using the same

Номер: US20120107401A1

Автор: William F. Mckay

Принадлежит: WARSAW ORTHOPEDIC INC

Osteoconductive matrices and methods are provided that have one or more statins disposed therein. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustain release of the statin and facilitate bone formation and repair of the fracture site.

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Номер записи: 24

10-05-2012 дата публикации

Method for treating immune disorders

Номер: US20120114555A1

Автор: Andrew T. Hutchinson, Darren R. Jones, Parisa Asvadi, Robert L. Raison, Rosanne D. Dunn

Принадлежит: IMMUNE SYSTEM THERAPEUTICS LTD

The present invention relates to the treatment of B-cell mediated immune disorders such as rheumatoid arthritis, systemic lupus erythromatomus, diabetes mellitus, and multiple sclerosis. In particular, the present invention relates to the treatment of B-cell mediated immune disorders using antibodies which bind to membrane-bound free light chain expressed on the surface of plasma cell precursors.

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Номер записи: 25

10-05-2012 дата публикации

Collagen extraction from aquatic animals

Номер: US20120114570A1

Автор: Awis Qurni Sazili, Badlishah Sham Baharin, Dzulkifly Mat Hashim, Harvinder Kaur, Jamilah Bakar, Kaur Harvinder, Russly Abdul Rahman, Umi Hartina Mohamad Razali

Принадлежит: UNIVERSITI PUTRA MALAYSIA (UPM)

The present invention relates to the use of fish skin as novel industrial source of collagen. Advantageously, said skin is obtained after the filleting or cutting of the fresh fish and frozen immediately after filleting/cutting, thus guaranteeing a very good quality of the base material, both from the bacteriological standpoint and from the standpoint of the native property of the protein.

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Номер записи: 26

10-05-2012 дата публикации

Olfactory stem cells and uses thereof

Номер: US20120114616A1

Автор: Chaker N. Adra

Принадлежит: King Faisal Specialist Hospital and Research Centre

Some aspects of this invention are based, at least in part, on the discoveries (i) pluripotent stem cell populations can be obtained from olfactory mucosa, (ii) that various regions of the olfactory mucosa contain pluripotent stem cells, (iii) that cells from these olfactory mucosa derived stem cell populations can be maintained in cultures containing EGF and/or bFGF, (iv) that cells from these olfactory mucosa derived stem cell populations are able to form neurospheres, and/or (v) that cells from these olfactory mucosa derived stem cell populations can differentiate into various lineages, including mesenchymal and neuronal lineages.

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Номер записи: 27

10-05-2012 дата публикации

Integrin heterodimer and an alpha subunit thereof

Номер: US20120114708A1

Автор: Donald Gullberg

Принадлежит: HANSA MEDICAL AB

A recombinant or isolated integrin heterodimer comprising a novel subunit α11 in association with a subunit β is described. The integrin or the subunit α11 can be used as marker or target of all types of cells. The integrin or subunit α11 thereof can be used as marker or target in different physiological or therapeutic methods. They can also be used as active ingredients in pharmaceutical compositions and vaccines.

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Номер записи: 28

10-05-2012 дата публикации

Porogen Containing Calcium Phosphate Cement Compositions

Номер: US20120115780A1

Автор: Ali Sait Ismailoglu, David C. Delaney, Duran N. Yetkinler, Ravinder Singh, Sahil Jalota

Принадлежит: Skeletal Kinetics LLC

Porogen containing calcium phosphate cement compositions are provided. Aspects of the cement compositions include a dry calcium phosphate reactant component, a setting fluid component and a porogen component. The porogen component includes at least first and second porogens having different pore forming profiles. Aspects of the invention include combining the cement components to produce a settable composition. Aspects of the invention further include the settable compositions themselves as well as kits for preparing the same. Methods and compositions as described herein find use in a variety of applications, including hard tissue repair applications.

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Номер записи: 29

17-05-2012 дата публикации

cRGD PEPTIDE DERIVATIVE AND ITS MANUFACTURE, AND IMPLANT HAVING A COATING CONTAINING A cRGD PEPTIDE DERIVATIVE

Номер: US20120121682A1

Автор: Alexander Borck

Принадлежит: BIOTRONIK AG

Various embodiments of the invention relate to a cRGD peptide derivative and an associated manufacturing method, and to an implant having a coating containing a cRGD peptide derivative. One aspect of the invention is the provision of a cRGD peptide derivative having the formula (1): wherein x=0-8, in particular 4-8, and R is a hydrophobic group.

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Номер записи: 30

17-05-2012 дата публикации

Lactoferrin-based biomaterials for tissue regeneration and drug delivery

Номер: US20120122767A1

Автор: Lakshmi Sreedharan Nair

Принадлежит: University of Connecticut

The invention provides biomatrix compositions comprising cross-linked lactoferrin, either alone or in combination with other organic or inorganic components. Also provided are methods of making and using the biomatrix compositions. As described herein, cross-linked lactoferrin biomatrix retains the bioactivities of the lactoferrin molecule. The biomatrix composition can act as a matrix for cell adhesion and growth and is particularly useful in musculoskeletal tissue regeneration. The biomatrix compositions can be pre-formed or injectable and can act as a cell, drug or protein delivery vehicle.

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Номер записи: 31

17-05-2012 дата публикации

Novel crystalline form of atorvastatin hemi-calcium salt, hydrate thereof, and method of producing the same

Номер: US20120123132A1

Автор: Do Yeon Oh, Doo Seong Choi, Hoe Joo Son, Kyung Ju Lee, Sun Ho Chang

Принадлежит: KYONGBO PHARM

The present invention provides a novel crystalline form of [R-(R * ,R * )]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-mthylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptanoic acid hemi-calcium salt (atorvastatin hemi-calcium salt) of the following formula 1, which is known to be useful as a drug, a hydrate thereof and a preparation method thereof:

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Номер записи: 32

24-05-2012 дата публикации

Il-17 homologous polypeptides and therapeutic uses thereof

Номер: US20120128627A1

Автор: Audrey Goddard, Austin Gurney, Ellen Filvaroff, Hanzhong Li, Jian Chen, William I. Wood

Принадлежит: Individual

The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

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Номер записи: 33

24-05-2012 дата публикации

Modified hyaluronic acid polymer compositions and related methods

Номер: US20120128741A1

Автор: David M. Gravett, George Y. Daniloff, Pingren He

Принадлежит: Carbylan Biosurgery Inc

The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.

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Номер записи: 34

24-05-2012 дата публикации

Methods and compositions for diagnosing ankylosing spondylitis using biomarkers

Номер: US20120129185A1

Автор: Robert L. Wong, Walter P. Maksymowych

Принадлежит: Abbott Biotech Ltd Bermuda

The invention provides a method for determining the efficacy of a TNFα inhibitor, such as a TNFα antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS), using a collagen degradation biomarker and/or a synovitis biomarker.

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Номер записи: 35

24-05-2012 дата публикации

Compositions and methods for arthrodetic procedures

Номер: US20120130435A1

Автор: Charles E. Hart, Samuel E. Lynch

Принадлежит: Biomimetic Therapeutics LLC

The present invention provides compositions and methods for facilitating fusion of bones in a joint. The present invention provides compositions and methods for promoting fusion of bones in arthrodetic procedures. In one embodiment, a method of performing an arthrodetic procedure comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to a site of desired bone fusion in a joint.

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Номер записи: 36

31-05-2012 дата публикации

Methods of correcting imbalance between bone resorption and bone formation and kits and compositions therefor

Номер: US20120135930A1

Автор: Alain Moreau, Genevieve Mailhot

Принадлежит: CHU SAINTE-JUSTINE

Compounds, methods, uses, compositions, kits and packages for the treatment of imbalance between bone resorption and bone formation, based on uses of 4-phenyl-2-propionamidotetralin (4-P-PDOT) and analogs, derivatives, prodrugs, precursors thereof, and salts thereof, are described.

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Номер записи: 37

31-05-2012 дата публикации

Ameliorant for renal insufficiency

Номер: US20120136068A1

Автор: Bang Luu, Hiroto Suzuki, Keisuke Sato, Masashi Yamada, Motoaki Saito

Принадлежит: Meiji Co Ltd

The present invention relates to an agent for improving renal dysfunction comprising as an active ingredient a compound represented by the following formula (1): wherein each R 1 , R 2 , and R 3 represents a hydrogen atom or a methyl group, and X represents a linear or branched alkylene or alkenylene group having 10 to 28 carbon atoms.

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Номер записи: 38

07-06-2012 дата публикации

Composition including an unsaponifiable fraction

Номер: US20120141387A1

Автор: David Daguet, Philippe Msika

Принадлежит: Laboratoires Expanscience SA

The present invention relates to a composition, notably cosmetic, nutraceutical, dermatological, pharmaceutical or dietary, including at least one unsaponif iable extract, a drug including one such composition, the use of one such composition, a treatment method consisting in administering one such composition and a method comprising the administration of one such composition.

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Номер записи: 39

07-06-2012 дата публикации

Highly-mineralized osteogenic sponge compositions and uses thereof

Номер: US20120141557A1

Автор: William F. Mckay

Принадлежит: WARSAW ORTHOPEDIC INC

Osteogenic sponge compositions having enhanced osteoinductive properties for use in bone repair are described. The compositions include a quickly resorbable porous carrier, a more slowly resorbed mineral scaffold and an osteogenic factor, preferably a bone morphogenetic protein. The compositions enable increased osteoinductive activity while retaining a reliable scaffold for the formation of new bone at an implant site. Methods for therapeutic use of the compositions are also described.

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Номер записи: 40

07-06-2012 дата публикации

Biomolecular coating for implants

Номер: US20120142597A1

Автор: Abigail M. Wojtowicz, Andres J. Garcia, Barbara D. Boyan, Catherine D. Reyes, David M. Collard, Jenny E. RAYNOR, Robert E. Guldberg, Timothy Petrie, Zvi Schwartz

Принадлежит: Georgia Tech Research Corp

Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an α 2 β 1 or α 5 β 1 integrin-specific ligand are provided. The substrates and devices coated with an α 2 β 1 or α 5 β 1 integrin-specific ligand are shown to have greater tissue formation on the surface relative to controls, in particular greater bone formation.

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Номер записи: 41

07-06-2012 дата публикации

Targetted drug delivery to the bone

Номер: US20120142641A1

Автор: Say Chye Joachim Loo, Subramanian Venkatraman

Принадлежит: NANYANG TECHNOLOGICAL UNIVERSITY

The present invention relates to a complex of a bisphosphonate compound, methods of preparing such complex and uses thereof.

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Номер записи: 42

07-06-2012 дата публикации

Implantable material and a method for the preparation thereof

Номер: US20120142898A1

Автор: Andrew Michael Collins, Christopher Holland, David Philip Knight, Nicholas James Vavasour Skaer, Tom Louis Dirk Gheysens

Принадлежит: Individual

A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C.; and subsequently degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.

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Номер записи: 43

14-06-2012 дата публикации

Composition for hard tissue formation and, dentin or pulp regeneration containing ameloblast, apical bud cell or its culture fluid as an active ingredient

Номер: US20120148538A1

Автор: Jihyun Lee, Joo-Cheol PARK, Won-Jun SHON

Принадлежит: SNU R&DB FOUNDATION

The present invention relates to a composition for hard tissue formation and dentin, or dental pulp regeneration comprising ameloblasts, apical bud cells, or its culture fluid as an active ingredient. The ameloblasts, apical bud cells, or its culture fluid promotes the differentiation of odontoblasts, human dental pulp stem cells and osteoblasts, increases DSPP promoter activity, induces dental pulp regeneration of dental pulp stem cells, and induces hard tissue formation significantly in vivo, so that they can be effectively used for a composition for promoting hard tissue formation and dentin or dental pulp regeneration.

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Номер записи: 44

14-06-2012 дата публикации

Methods and Compositions for Tissue Engineering

Номер: US20120148539A1

Автор: Moulay Hicham Alaoui-Ismaili

Принадлежит: Individual

Disclosed herein are methods and compositions for promoting endochondral bone formation. The invention includes methods of promoting endochondral bone formation by down-regulating the expression of the DIO2 gene or the activity of the deiodinase protein. The invention also includes methods of up-regulating the activity of the FGFR3, ADAMTS9, HEY1, HAS3, and/or MFI2 genes and/or the activity of the expression products of those genes to promote endochondral bone formation. The invention also includes compositions of BMP-7 and agonists of FGFR3, ADAMTS9, HEY1, HAS3, and/or MFI2 proteins. Compositions can further include mesenchymal stem cells.

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Номер записи: 45

14-06-2012 дата публикации

PEG-Urate Oxidase Conjugates and Use Thereof

Номер: US20120149083A1

Автор: L. David Williams, Mark G.P. Saifer, Merry R. Sherman, Michael S. Hershfield, Susan J. Kelly

Принадлежит: Duke University, Mountain View Pharmaceuticals Inc

A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.

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Номер записи: 46

21-06-2012 дата публикации

Method for inducing extended self-renewal of functionally differentiated somatic cells

Номер: US20120156179A1

Автор: Michael Sieweke

Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Institut National de la Sante et de la Recherche Medicale INSERM, Universite de la Mediterranee Aix Marseille II

The present invention relates to a method for inducing proliferation of functionally differentiated somatic cells comprising a step of activating expression of a Myc family gene and a KIf family gene in said cells or contacting said cells with a Myc family protein and a KIf family protein.

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Номер записи: 47

21-06-2012 дата публикации

Soluble lymphotoxin-beta receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological diseases

Номер: US20120156214A1

Автор: Fabienne MacKay, Jeffrey L. Browning, Paul D. Rennert, Paula S. Hochman

Принадлежит: BIOGEN IDEC MA INC

Compositions and methods comprising “lymphotoxin-β receptor blocking agents” which block lymphotoxin-β receptor signalling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.

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Номер записи: 48

05-07-2012 дата публикации

Novel Formulations of Volatile Anesthetics and Methods of Use for Reducing Inflammation

Номер: US20120171281A1

Автор: Danguole Spakevicius, Hatice Ozsoy

Принадлежит: University of Texas System

The present invention provides methods for treating inflammation or a wound in a subject in need of such wound treatment or inflammation treatment by delivering a volatile anesthetic to the wound or the inflammation site.

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Номер записи: 49

05-07-2012 дата публикации

Co-crystals of tramadol and coxibs

Номер: US20120172398A1

Автор: Carlos Ramon Plata Salaman, Nicolas Tesson

Принадлежит: Laboratorios del Dr Esteve SA

The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses in pharmaceutical formulations for the treatment of pain.

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Номер записи: 50

12-07-2012 дата публикации

Unsaturated Heterocyclic Derivatives

Номер: US20120178716A1

Автор: David C. Dalgarno, R. Mathew Thomas, Rajeswari Sundaramoorthi, Tomi K. Sawyer, Wei-Sheng Huang, William C. Shakespeare, Xiaotian Zhu, Yihan Wang

Принадлежит: Ariad Pharmaceuticals Inc

This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

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Номер записи: 51

19-07-2012 дата публикации

Theophylline Derivative Inhibits Osteoporosis

Номер: US20120184570A1

Автор: Ing-Jun Chen, Jwu-Lai Yeh

Принадлежит: KAOHSIUNG MEDICAL UNIVERSITY

The theophylline derivative disclosed in the present invention is characterized by having the pharmaceutical functions of osteoporosis. The theophylline derivative protects against bone resorption and inflammatory mediator infiltration.

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Номер записи: 52

26-07-2012 дата публикации

Co-precipitate comprising a phosphodiesterase-5 inhibitor (pde-5-inhibitor) and a pharmaceutically compatible carrier, production and use thereof

Номер: US20120189694A1

Автор: Frank Muskulus, Katrin Rimkus

Принадлежит: ratiopharm GmbH

The invention relates to a co-precipitate comprising a phosphodiesterase-5 inhibitor (PDE-5-inhibitor) and a pharmaceutically compatible copolymer carrier comprising 2 or more different acrylic acid derivatives, a method for production thereof and a medication comprising the co-precipitate according to the invention, a method for producing said medication and the use of said medication for treating an illness wherein the inhibiting of phosphodiesterase-5 is of therapeutic benefit.

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Номер записи: 53

26-07-2012 дата публикации

Modular Extracorporeal Systems and Methods for Treating Blood-Borne Diseases

Номер: US20120189711A1

Автор: David G. Greenberg, Juan N. Walterspiel, Scott Puritz, Tatiana Koutchma

Принадлежит: Somerset Group Enterprises Inc

Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

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Номер записи: 54

26-07-2012 дата публикации

Novel oral forms of a phosphonic acid derivative

Номер: US20120190647A1

Автор: David Weyna, Mazen Hanna, Miranda Cheney, Ning SHAN

Принадлежит: Thar Pharmaceuticals Inc

Novel solution complexes of zoledronic acid are described which give rise to improved properties of zoledronic acid. The invention includes aqueous solution and molecular complexes of zoledronic acid with and optical isomers of asparagine, histidine, arginine and proline as well as pharmaceutical complexes containing them and methods of treatment using them.

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Номер записи: 55

02-08-2012 дата публикации

Injectible, biocompatible synthetic bone growth composition

Номер: US20120195982A1

Автор: Chenguang Liu, Eric G. Hu, Fuzai Cui, Kun Hu, Zonggang Chen

Принадлежит: Beijing Allgens Medical Science and Technology Co Ltd

An injectible, biocompatible synthetic bone growth composition comprising a mineralized collagen and a calcium sulfate component. The composition is formed into injectible formulation that may be provided at the site of a skeletal defect via minimally invasive manner. An osteoinductive component may be further added, either before or after forming the unitary article. The composition may be formulated as a paste or putty and facilitates bone growth and/or repair.

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Номер записи: 56

02-08-2012 дата публикации

Pharmaceutical compositions of cytidine analogs and methods of use thereof

Номер: US20120196823A1

Автор: Anthony Tutino, Jeffrey B. Etter, Mei Lai

Принадлежит: Celgene Corp

The present disclosure provides pharmaceutical compositions comprising cytidine analogs for parenteral administration. Also provided are methods of preparing the compositions and methods of treating diseases and disorders using the compositions provided herein.

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Номер записи: 57

09-08-2012 дата публикации

Antibodies specific for dkk-1

Номер: US20120201835A1

Автор: Alfred A. Reszka, Donald B. Kimmel, Fang Chen, Fubao Wang, Helmut Glantschnig, John E. Fisher, Zhiqiang An

Принадлежит: Merck and Co Inc

Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis.

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Номер записи: 58

16-08-2012 дата публикации

Thin shell graft for cartilage resurfacing

Номер: US20120207718A1

Автор: Kevin R. Stone, Thomas J. Turek

Принадлежит: Individual

An articular cartilage shell graft is designed to treat the arthritic population for which current biologic treatments are insufficient and as a biological-stage repair for intervention before prosthetic knee arthroplasty.

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Номер записи: 59

16-08-2012 дата публикации

Cartilage Repair

Номер: US20120207847A1

Автор: Michael Philbrook, Peter K. Jarrett, Timothy J. Butler

Принадлежит: Genzyme Corp

This invention relates to compositions, methods of preparation thereof, and use thereof for cartilage repair.

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Номер записи: 60

23-08-2012 дата публикации

Immunoneutral silk-fiber-based medical devices

Номер: US20120210547A1

Автор: David J. Horan, Gregory H. Altman, Jingsong Chen, Rebecca Horan

Принадлежит: Allergan Inc

Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.

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Номер записи: 61

23-08-2012 дата публикации

Process for demineralization of bone matrix with preservation of natural growth factors

Номер: US20120213859A1

Автор: Benjamin P. Luchsinger, Darrel L. Holmes, Gregory A. Juda, Jesus Hernandez, Kelly R. Kirker, Nancy J. Shelby, Steven M. Scott

Принадлежит: Bacterin International Inc

A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

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Номер записи: 62

30-08-2012 дата публикации

Freeze-dried fibrin matrices and methods for preparation thereof

Номер: US20120219534A1

Автор: Avner Yayon, Malkit Azachi, Micha Gladnikoff

Принадлежит: Prochon Biotech Ltd

Methods for treating diseased or injured tissue by implanting into the tissue at a site of the disease or injury a porous freeze-dried fibrin matrix formed from plasma proteins. The proteins include fibrinogen cleaved by the action of thrombin at varying concentrations sufficient to cleave the fibrinogen and Factor XIII. The matrix has less than 10% residual moisture and is devoid of exogenous anti-fibrinolytic agents, plasminogen and of organic chelating agents. Alternatively, the plasma proteins comprise partially purified plasma proteins that are devoid of plasminogen.

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Номер записи: 63

30-08-2012 дата публикации

Biodegradable fiber and fiber wadding for filling bone defects and method for producing the same

Номер: US20120219595A1

Автор: Toshihiro Kasuga, Xianfeng Yao, Yoshio Ota

Принадлежит: Nagoya Institute of Technology NUC, Orthorebirth Co Ltd

A fiber wadding formed from a biodegradable polymer fiber containing calcium carbonate fine particles including silicon that is characterized in that hydroxyapatite is precipitated and scattered nearly uniformly on the surface of the biodegradable polymer fiber is disclosed. Further, a method for production of fiber wadding that includes the steps of heating and kneading silicon-containing calcium carbonate fine particles and a biodegradable polymer to produce a composite, dissolving the composite by mixing the composite with a solvent to obtain a spinning solution, processing the spinning solution into fiber wadding by using electrospinning method, and alternatingly immersing the fiber wadding in a calcium aqueous solution and a phosphate aqueous solution to cause precipitation of hydroxyapatite in an approximately uniformly scattered manner on the surface of the fibers is disclosed.

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Номер записи: 64

06-09-2012 дата публикации

Therapeutic combination for painful medical conditions

Номер: US20120225119A1

Автор: Bettina Beyreuther, Thomas Stöhr

Принадлежит: UCB PHARMA GMBH

An embodiment of the present invention relates to a therapeutic combination including (a) lacosamide and/or a pharmaceutically acceptable salt thereof; and (b) levetiracetam and/or a pharmaceutically acceptable salt thereof. The combination can be provided in a single dosage form or separate dosage forms.

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Номер записи: 65

13-09-2012 дата публикации

Tissue transplant compositions and methods for use

Номер: US20120230966A1

Автор: John M. Garvey, Keith D. Crawford, Pamela Layton

Принадлежит: Brigham and Womens Hospital Inc, PARCELL LABS LLC

Provided are transplants and methods for augmenting formation and restoration of organ and tissue, for example, bone formation, by administering autologous or allogeneic human embryonic-like adult stem cells (ELA cells). Also provided is a method for augmenting formation of tissues and organs by administering a transplant having ELA stem cells or combination of ELA stem cells.

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Номер записи: 66

13-09-2012 дата публикации

Coated Tablets, Their Method of Preparation, and Related Uses

Номер: US20120231077A1

Автор: Kern Lystrup, Leif Knudsen, Peter B. Samuelsen

Принадлежит: SPORTSCOM DANMARK APS

A tablet comprising a tabletted core comprising a triglyceride granulate, and an enteric coating surrounding said tabletted core. In particular, a tablet wherein the tabletted core contains esterified omega-3 fatty acids such as eicosapentaenoic acid and/or docosahexaenoic acid.

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Номер записи: 67

13-09-2012 дата публикации

Use of Rapamycin and Rapamycin Derivatives for the Treatment of Bone Loss

Номер: US20120232011A1

Автор: Michaela Kneissel, Mira Susa Spring

Принадлежит: Individual

The present invention relates to a new use of rapamycin and rapamycin derivatives.

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Номер записи: 68

20-09-2012 дата публикации

Modulation Of Osteoclast Differentiation

Номер: US20120238501A1

Автор: Refael Aharon, Zvi Bar-Shavit

Принадлежит: NITZOZOT Ltd

The present invention concerns the use of an aquaprin-9 (AQP-9) modulator for the preparation of a pharmaceutical composition for treating or preventing a pathological condition associates with unbalanced osteoclast differentiation. In accordance with one embodiment, the modulator is an AQP-9 inhibitor. An example of an inhibitor is phloretin which was shown to inhibit osteoclast differentiation following induction of bone marrow cells with RANKL. The invention also concerns methods for modulating osteoclast differentiation, methods for treating pathological conditions associated with unbalanced osteoclast differentiation as well as pharmaceutical composition comprising such modulators.

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Номер записи: 69

20-09-2012 дата публикации

Cytotoxic compounds

Номер: US20120238604A1

Автор: Robin Scaife

Принадлежит: Molecular Discovery Systems Ltd

The present invention relates to a compound of general formula (I) or a pharmaceutically acceptable salt or solvate or thereof. In particular, the present invention relates to a method treating diseases involving cell proliferation, migration, apoptosis, or adhesion, comprising administering to a human or non-human mammalian patient an effective amount of a compound of general formula (I) or a pharmaceutically acceptable salt or solvate or thereof.

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Номер записи: 70

27-09-2012 дата публикации

Stable formulations of polypeptides and uses thereof

Номер: US20120244158A1

Автор: Ann Brige, Veronique De Brabandere

Принадлежит: Ablynx NV

Formulations are provided that contain single variable domains with a good solubility and good stability under different storage, transportation and stress conditions. The formulations are useful as pharmaceutical formulation. The formulation comprises an aqueous carrier with a pH of 5.5 to 8.0, a buffer selected from the group consisting of histidine pH 6.0-6.5, hepes pH 7.0-8.0, MES pH 6.0, succinate pH 6.0-6.5 and acetate pH 5.5-6.0; an excipient; and/or a surfactant selected from Tween 80, Tween 20 and poloxamers. The formulation is further characterized that it has an inorganic salt concentration of 150 mM or lower. The invention further relates to containers and pharmaceutical units comprising such formuSations and to methods for preparing and prophylactic and therapeutic uses of the formulations and pharmaceutical units of the invention.

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Номер записи: 71

27-09-2012 дата публикации

WNT10-Derived Peptide and Use Thereof

Номер: US20120245086A1

Автор: Eun Mi Kim, Kyoung Mi Cho, Sang Su Song, Young Ji Chung

Принадлежит: Caregen Co Ltd

The present invention relates to a WNT10-derived peptide, a composition for improving hair loss and skin conditions using the same, and a composition for treating a WNT10 signal transduction pathway-related disorder and DKK-1 protein-induced disorder using the same. WNT10-derived peptide of the present invention possesses identical or similar activities to natural-occurring WNT10, and has much higher stability and skin penetration potency than natural-occurring WNT10. Therefore, the composition containing the present peptide not only shows excellent effects on improvement in hair loss (for example, promotion of hair growth or production of hair), but also has superior efficacies on treatment of a WNT10 signal transduction pathway-related disorder and a DKK-1 protein-induced disorder. In addition, the outstanding activity and stability of the present peptide described above may be greatly advantageous in application to pharmaceutical compositions, quasi-drugs and cosmetics.

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Номер записи: 72

04-10-2012 дата публикации

Pth-containing therapeutic/prophylactic agent for osteoporosis, characterized in that pth is administered once a week in a unit dose of 100 to 200 units

Номер: US20120252729A1

Автор: Hiroki Kato, Kazuyoshi Hori, Masashi Serada, Nobuyuki Kobayashi, Shinichiro Shirae, Tatsuhiko Kuroda, Yasuo Nakamura, Yoshihide Nozaki, Yuiko Oya

Принадлежит: Asahi Kasei Pharma Corp

A method of treating osteoporosis by PTH that has excellent safety and high efficacy is disclosed, along with a method for inhibiting/preventing bone fractures by PTH that has excellent safety, as well as providing a drug to do this. A drug containing PTH as the active ingredient is disclosed, characterized in that a unit dose of PTH of 100 to 200 units is administered weekly in the above method.

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Номер записи: 73

11-10-2012 дата публикации

Linkable Lewis X Analogs

Номер: US20120258043A1

Автор: Edmund R. Marinelli, Kondareddiar Ramalingam, Radhakrishna Pillai, Ramachandran Ranganathan, Rolf E. Swenson

Принадлежит: Bracco Suisse SA

Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe X ) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLe X compositions. In particular, the disclosed SLe X compounds can be used to prepare selectin binding ligand conjugates by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLe X compounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl Le X , and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.

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Номер записи: 74

11-10-2012 дата публикации

Reagents, Methods and Systems to Suppress Pro-Inflammatory Cytokines

Номер: US20120258999A1

Автор: Jeffrey C. Marx

Принадлежит: WARSAW ORTHOPEDIC INC

The present invention relates to reagents, methods and systems to treat inflammation and pain in a subject using small interfering RNA (siRNA) molecules targeted to either TNFα, IL1 IL6 and other pro-inflammatory cytokines.

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Номер записи: 75

18-10-2012 дата публикации

Medical compositions containing ghrelin

Номер: US20120264691A1

Автор: Masaru Matsumoto, Yoshiharu Minamitake

Принадлежит: Daiichi Sankyo Co Ltd

It is provided a pharmaceutical composition stably containing ghrelin or its derivative, which is an endogenous growth hormone secretagogue (GHS) to a growth hormone secretagogue-receptor (GHS-R), comprising a aqueous solution containing the ghrelins having pH range of 2 to 7, wherein the aqueous solution having pH range of 2 to 7 is a buffer solution, especially, glycine hydrochloride buffer, acetate buffer, citrate buffer, lactate buffer, phosphate buffer, citric acid-phosphate buffer, phosphate-acetate-borate buffer or phthalate buffer, and the concentration of the ghrelins in the solution is from 0.03 nmol/mL to 6 μmol/mL.

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Номер записи: 76

18-10-2012 дата публикации

Salt forms of [R-(R,R)]-2-(4-flurorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid

Номер: US20120264934A1

Автор: Anthony Michael Campeta, Jason Albet Leonard, Joseph F. Krzyzaniak

Принадлежит: PFIZER INC

Novel salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.

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Номер записи: 77

18-10-2012 дата публикации

Transdermal Delivery of Medicinal Cetylated Fatty Esters using Phonophoresis or Iontophoresis

Номер: US20120265119A1

Автор: Jack Bain Bookout, Raj R. Barathur

Принадлежит: Cymbiotics Inc

The use of phonophoresis or iontophoresis to enhance transdermal delivery of medicinal Cetylated fatty esters when applied in cream or gel compositions is disclosed. These compositions provide hydrophilic salt forms and penetration-enhancing vehicles that work in conjunction with phonophoresis or iontophoresis to increase the efficacy of the medicinal actives.

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Номер записи: 78

01-11-2012 дата публикации

Bone Growth Compositions and Methods

Номер: US20120276204A1

Автор: Benjamin J. REMINGTON, David J. Bearss, Kavian Shahi

Принадлежит: NeuroPro Technologies Inc

The present invention provides an improved technique for spinal fusion involving the administration of an HMG-CoA reductase inhibitor to a fusion. The HMG-CoA reductase inhibitor is preferably delivered to the site by a carrier. More preferably, the HMG-CoA reductase inhibitor is delivered to the site by a non-compressible delivery vehicle. The invention is suitable for promoting non-anatomic or heterotopic bone growth between any bony surfaces where bone growth is desired but does not naturally occur.

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Номер записи: 79

01-11-2012 дата публикации

Compositions and methods for inducing bone growth and inhibiting bone loss

Номер: US20120277300A1

Автор: Yuanlong Pan

Принадлежит: Nestec SA

Compositions useful for inducing bone growth or inhibiting bone loss in an animal comprising one or more isoflavones or isoflavone metabolites and methods for inducing bone growth or inhibiting bone loss in an animal utilizing such compositions. The compositions and methods are particularly useful for post-menopause, post-andropause, gonadectomized, spayed, or neutered animals.

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Номер записи: 80

01-11-2012 дата публикации

Chroman-derived anti-androgens for treatment of androgen mediated disorders

Номер: US20120277301A1

Автор: George Wilding, Todd A. Thompson

Принадлежит: WISCONSIN ALUMNI RESEARCH FOUNDATION

Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.

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Номер записи: 81

08-11-2012 дата публикации

Medical implants containing adenosine receptor agonists and methods for inhibitiing medical implant loosening

Номер: US20120283211A1

Автор: Aranzazu Mediero Munoz, Bruce N. Cronstein

Принадлежит: Individual

The invention provides methods and compositions for reducing or inhibiting bone resorption, osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a compound or agent that modulates an adenosine receptor such as the adenosine A 2A receptor, in particular, an agonist of an adenosine A 2A receptor. The invention also extends to pharmaceutical compositions comprising such an agent that modulates an adenosine receptor such as an adenosine A 2A agonist and to prosthetic devices containing such an agent that modulates an adenosine receptor such as an A 2A agonist on one or more surfaces or within the prosthetic device such as, for example, suspended in the cement forming the prosthetic device.

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Номер записи: 82

15-11-2012 дата публикации

Gene delivery

Номер: US20120288505A1

Автор: Christopher D. Batich, Jon Dobson

Принадлежит: Nanotherics Ltd

The present invention relates to a method of delivery of a therapeutic agent to a target cell, the method comprising targeting particles comprising the therapeutic agent to the cell using magnetic means to apply a magnetic force to said particles so as to tend to move said particles towards said magnetic means and at the same time moving said magnetic means.

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Номер записи: 83

15-11-2012 дата публикации

Corticosteroids for the Treatment of Joint Pain

Номер: US20120288534A1

Автор: Anjali Kumar, Mark Moran, Michael D. Clayman, Neil Bodick, Robert C. Blanks

Принадлежит: Individual

Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and/or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous cortisol production.

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Номер записи: 84

22-11-2012 дата публикации

Injectable dbm for soft tissue repair

Номер: US20120294898A1

Автор: Christina Mossaad, Hsiu Ying Sherry Wang, Lawrence A. Shimp, William G. Hubbard

Принадлежит: WARSAW ORTHOPEDIC INC

An injectable pharmaceutical composition includes demineralized bone matrix (DBM) particles having a particle size in the range of about 25 microns to about 75 microns and a pharmaceutical carrier. The composition can further include adjuncts such as glycosaminoglycans, adjuvants such as chondroitin, and/or active ingredients such as anti-inflammatories.

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Номер записи: 85

22-11-2012 дата публикации

Reporter vector presenting extracellular binding capacity to metallic compounds

Номер: US20120295274A1

Автор: Eiichi Akahoshi, Mitsuko Ishihara

Принадлежит: Individual

According to one embodiment, a reporter vector presenting an extracellular binding capacity to metallic compounds contains a nucleotide sequence exhibiting a promoter activity depending on a specific condition, a nucleotide sequence encoding a metallic compound-binding peptide presented extracellularly, and a nucleotide sequence encoding transcription termination signals.

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Номер записи: 86

22-11-2012 дата публикации

Organic compounds

Номер: US20120295860A1

Автор: Matthias Kittelmann, Ulrich Hassiepen

Принадлежит: Individual

The present invention relates to a compound The instant invention relates to a compound of formulae (I A), (I B), (X A), (X B), (Y A) or (Y B), wherein R′ represents and R″ represents hydrogen, hydroxy, C 1 -C 7 alkoxy, C 1 -C 8 -alkanoyloxy, or R 5 R 4 N—CO—O—, where R 4 and R 5 independently are C 1 -C 7 alkyl or phenyl which is unsubstituted or substituted by a substitutent selected from C 1 -C 7 alkyl, C 1 -C 7 alkoxy, halogen and trifluoromethyl and where R 4 additionally is hydrogen; or R 4 and R 5 together represent C 3 -C 6 alkylene, in free form or in form of a pharmaceutically acceptable acid addition salt. Compounds of formulae (I A), (I B), (X A), (X B), (Y A) or (Y B) inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.

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Номер записи: 87

29-11-2012 дата публикации

Treatment of bone fracture

Номер: US20120301442A1

Автор: Simon Cool, Victor Nurcombe

Принадлежит: Agency for Science Technology and Research Singapore

The use of mesenchymal stem cells cultured in the presence of HS-2 for the treatment of bone fracture. Repair of bone fracture using such cells is enhanced compared with the treatment of bone fracture using mesenchymal cells cultured without HS-2. These mesenchymal stem cells may be formulated in a pharmaceutical composition and injected directly into tissues surrounding the fracture or used in a biocompatible implant or prosthesis.

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Номер записи: 88

29-11-2012 дата публикации

Boldline compounds for promoting bone growth

Номер: US20120301509A1

Автор: Debra Ellies, William Rosenberg

Принадлежит: OsteoGeneX Inc

The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.

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Номер записи: 89

06-12-2012 дата публикации

Piroxicam-Containing Transdermally Absorbable Preparation

Номер: US20120309749A1

Автор: Akiko Katayama, Katsuyuki Inoo

Принадлежит: Teikoku Seiyaku Co Ltd

An adhesive patch is provided in which piroxicam is formulated as a non-steroidal anti-inflammatory analgesic. In particular, provided is a piroxicam-containing transdermally absorbable adhesive patch in which an absorption promoter to piroxicam is formulated to achieve high anti-inflammatory and analgesic effects without inhibiting releasing of these drugs. The piroxicam-containing transdermally absorbable adhesive patch contains piroxicam as a medicinal component and oxybuprocaine or a pharmaceutically acceptable salt thereof as an absorption promoter. In the piroxicam-containing transdermally absorbable adhesive patch, the content of piroxicam is from 0.1% to 5% by weight to the total weight of a drug-containing plaster and the content of oxybuprocaine or the pharmaceutically acceptable salt thereof is from 1% to 30% by weight to the total weight of the drug-containing plaster.

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Номер записи: 90

13-12-2012 дата публикации

combination for the treatment of osteoarthritis

Номер: US20120316217A1

Автор: Arborio Mella Isabella, Edoardo Carlo Maria Conti, Francesco Saverio Dioguardi, Franco Conti, Giovanni Federico Maria Conti

Принадлежит: Professional Dietetics SpA

The present invention relates to the use of a combination of glycine, proline, and optionally a natural or synthetic viscosity-controlling polymer, and/or lysine and/or leucine, to prepare a composition for the treatment of osteoarthritis.

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Номер записи: 91

20-12-2012 дата публикации

Crystal structures and methods using same

Номер: US20120321606A1

Автор: Christian Wiesmann

Принадлежит: Genentech Inc

The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns modulators of FGFR3 function, and the identification and uses of said modulators.

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Номер записи: 92

20-12-2012 дата публикации

Humanized anti-il 10 antibodies for the treatment of systemic lupus erythematosus (sle)

Номер: US20120321618A1

Автор: André ENGLING, Andrea Wartenberg-Demand, Benjamin Daelken, Chantal Zuber, Christoph Bruecher, Christoph Uherek, Frank Osterroth, Judith Wessels-Kranz, Marcus Gutscher, Niklas Czeloth, Peter Röttgen

Принадлежит: BIOTEST AG

Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (Th-10), wherein said antibody or fragment thereof is capable of being administered to a subject in the absence of an intolerable increase in the level of pro-inflammatory cytokines. Further provided are methods of treatment involving the use of the antibody or fragment thereof.

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Номер записи: 93

27-12-2012 дата публикации

Methods of identifying obm modulators

Номер: US20120329671A1

Автор: Akihiro Tomoyasu, Eisuke Tsuda, Fumie Kobayashi, Hisataka Yasuda, Kanji Higashio, Kazuki Yano, Ken Takahashi, Kyoji Yamaguchi, Masaaki Goto, Masahiko Kinosaki, Naohiro Washida, Nobuaki Nakagawa, Nobuyuki Shima, Tomonori Morinaga

Принадлежит: AMGEN INC

Novel proteins and polypeptides binding to osteoclastogenesis inhibitory factor (OCIF) (OCIF-binding molecules, OBMs) and nucleic acids encoding these proteins and polypeptides are provided. Processes for producing these proteins, polypeptides, and nucleic acid molecules by genetic engineering are provided. Medicinal compounds are provided which comprise proteins and nucleic acids according to the invention, as well as proteins which bind to OBM, including anti-OBM antibodies. These compounds may be used for the treatment of bone disease.

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Номер записи: 94

27-12-2012 дата публикации

Dihydropteridinones, method for production and use thereof

Номер: US20120329803A1

Автор: Daniel Bischoff, Guenter Linz, Thomas Ebner

Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

The present invention relates to new dihydropteridinones of general formula (12) wherein the groups R 1 to R 5 and L, n, and m have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.

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Номер записи: 95

27-12-2012 дата публикации

Transgenic non-human animals

Номер: US20120331575A1

Автор: Angus Tester, Benjamin Cocks, Matthew Mcdonagh, Peter Hobman

Принадлежит: AGRICULTURE VICTORIA SERVICES PTY LTD, Murray Goulburn Co Opeartive Co Ltd

The invention provides a non-human transgenic animal comprising a transgene encoding angiogenin and food products comprising or obtained from the non-human transgenic animal and uses thereof.

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Номер записи: 96

03-01-2013 дата публикации

Composition and method to alleviate joint pain

Номер: US20130005828A1

Автор: John A. Minatelli, Lingan Rajendran, Rudi E. Moerck, Swati Sebastian Thomas, W. Stephen Hill

Принадлежит: US Nutraceuticals LLC

Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found with krill oil and/or marine oil in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.

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Номер записи: 97

10-01-2013 дата публикации

Preventive and/or therapeutic and/or aggravation suppressing agent for human arthritis deformans

Номер: US20130012440A1

Автор: Tatsuhiko Kuroda, Toshinori Ishizuya

Принадлежит: Asahi Kasei Pharma Corp

A medicine that is extremely useful for preventing and/or treating osteoarthritis, which includes a parathyroid hormone (PTH), and methods of use of such medicine.

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Номер записи: 98

10-01-2013 дата публикации

Compositions for Improving Bone Mass

Номер: US20130012445A1

Автор: Shunqing Wang, Xu Feng

Принадлежит: UAB RESEARCH FOUNDATION

The present invention provides a therapeutic composition, and method of use thereof, for improving bone mass, rigidity, or strength, or preventing and treating bone loss via modulation of the RANK signaling pathway. The therapeutic composition of the present invention comprises a RYBP peptide, or fragments thereof, that specifically interact with a motif of RANK to regulate osteoclastogenesis. The present invention further provides a composition, and method of use thereof, comprising a modulator that is capable of modulating the RYBP-RANK interaction, or modulating an effector in the RANK signaling pathway through the RYBP-RANK interaction.

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Номер записи: 99

10-01-2013 дата публикации

Identification of free-b-ring flavonoids as potent cox-2 inhibitors

Номер: US20130012463A1

Автор: Eric E. Rhoden, QI Jia, Scott Waite, Timothy C. Nichols

Принадлежит: Unigen Inc

The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.

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Номер записи: 100

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