Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 7079. Отображено 100.
05-01-2012 дата публикации

Sensitivity enhancement in grating coupled surface plasmon resonance by azimuthal control

Номер: US20120002203A1
Автор: Chee Cheong Wong, Filippo Romanato, Gianluca Ruffato, Husen Kartasamita Kang, Lee Kwang Hong
Принадлежит: NANYANG TECHNOLOGICAL UNIVERSITY, UNIVERSITA DEGLI STUDI DI PADOVA

A method and a system for the enhancement of the sensitivity in surface plasmon resonance (SPR) sensors based metallic grating by exploiting the conical configuration is presented. We consider the propagation of surface plasmon polaritons (SPPs) excited by light from the visible to infrared spectrum range, incident on a plasmonic grating at different directions by varying both the zenith and azimuthal angles. For specific azimuthal angles, SPPs propagate in the grating plane perpendicular to the incident light momentum. This is the condition that allows increasing the number of different excited SPPs modes largely. We exploit this effect to increase the sensor sensitivity with the change of refractive index of thin film on the plasmonic grating surface. Polarization effects also contribute to a further modes enhancement and increase the sensitivity. A scheme for a lab-on-chip implementation of a system that allows a parallel detection in microfluidic channels has been shown.

Подробнее
Номер записи: 1
26-01-2012 дата публикации

Optics collection and detection system and method

Номер: US20120021525A1
Автор: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
Принадлежит: Pacific Biosciences of California Inc

Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

Подробнее
Номер записи: 2
02-02-2012 дата публикации

On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference

Номер: US20120026509A1
Автор: Axel Scherer, Changhuei Yang, Demetri Psaltis, Xin Heng, Xiquan Cui
Принадлежит: California Institute of Technology CalTech

A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface wave assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector.

Подробнее
Номер записи: 3
08-03-2012 дата публикации

Blood Chamber for an Optical Blood Monitoring System

Номер: US20120059234A1
Автор: Louis L. Barrett, Perry N. Law
Принадлежит: Hema Metrics LLC

An extracorporeal blood chamber for an optical blood monitoring system includes an opaque chamber body in order to prevent inaccuracies when measuring oxygen saturation levels due to light ducting, which can occur at low oxygen saturation levels and low hematocrit levels. In one embodiment, the blood chamber need not include a moat as is present in conventional blood chambers.

Подробнее
Номер записи: 4
29-03-2012 дата публикации

Fiber probe based microfludic raman spectroscopy

Номер: US20120075627A1
Автор: Gajendra Pratap Singh, Khay Tan, Kishan Dholakia, Praveen Cheriyan Ashok
Принадлежит: University of St Andrews

A microfluidic device comprising at least one microfluidic channel with an input and an output for allowing fluid flow; and at least one Raman fiber based probe having an excitation fiber probe and/or a collection fiber probe positioned so that one end of the probe is in the microfluidic channel.

Подробнее
Номер записи: 5
19-04-2012 дата публикации

Systems and methods for collecting tear film and measuring tear film osmolarity

Номер: US20120090388A1
Автор: Benjamin Sullivan, Eric Donsky
Принадлежит: Tearlab Res Inc

A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.

Подробнее
Номер записи: 6
31-05-2012 дата публикации

Systems And Methods For Multi-Wavelength SPR Biosensing With Reduced Chromatic Aberration

Номер: US20120133943A1
Автор: Anping Liu, Guangshan Li, Jinlin Peng, Norman Henry Fontaine
Принадлежит: Corning Inc

Systems and methods for sensing a surface plasmon resonance (SPR) biosensor using two or more wavelengths and with reduced chromatic aberration are disclosed. The system includes a beam-forming optical system that has chromatic aberration at the two or more wavelengths. A light source system provides respectively light of the two or more wavelengths, with light of each wavelength provided from a different distance from the beam-forming optical system. The different distances are selected to reduce or eliminate adverse effects of chromatic aberration on the formation of a focus spot on the SPR biosensor chip. An illumination system for illuminating a SPR biosensor using different light having different wavelengths is also disclosed.

Подробнее
Номер записи: 7
31-05-2012 дата публикации

Multi-Shell Microspheres With Integrated Chromatographic And Detection Layers For Use In Array Sensors

Номер: US20120135396A1
Автор: Adrian Goodey, Dean P. Neikirk, Eric Anslyn, Jason Shear, John T. McDevitt
Принадлежит: University of Texas System

The development of miniaturized chromatographic systems localized within individual polymer microspheres and their incorporation into a bead-based cross-reactive sensor array platform is described herein. The integrated chromatographic and detection concept is based on the creation of distinct functional layers within the microspheres. In this first example of the new methodology, complexing ligands have been selectively immobilized to create “separation” layers harboring an affinity for various analytes. Information concerning the identities and concentrations of analytes may be drawn from the temporal properties of the beads' optical responses, Varying the nature of the ligand in the separation shell yields a collection of cross-reactive sensing elements well suited for use in array-based micro-total-analysis systems.

Подробнее
Номер записи: 8
31-05-2012 дата публикации

Method and Apparatus for Detecting and Quantifying a Chemical Substance Employing an Optical Transmission Property of Metallic Islands on a Transparent Substrate

Номер: US20120135536A1
Автор: Alexander Vaskevich, Gregory Kalyuzhny, Israel Rubinstein
Принадлежит: Yeda Research and Development Co Ltd

A sensor for use in detecting and analyzing predetermined chemical substances is presented. The sensor comprises: a first structure configured for binding to a certain substance and comprising a substantially transparent substrate with respect to electromagnetic radiation of a predetermined wavelength range and a plurality of metallic islands deposited onto the transparent substrate and having a first spectral transmission profile with respect to the electromagnetic radiation of the predetermined wavelength range; the metallic islands comprising metallic films having a thickness selected such that binding of said certain substance to the first structure provides a change in a localized surface plasmon extinction in the metallic films being in a predetermined correlation with a change in a spectral transmission profile of the electromagnetic radiation of the predetermined wavelength range transmitted through the first structure and the substance as compared to said first spectral transmission profile, thereby enabling detection of said substance.

Подробнее
Номер записи: 9
14-06-2012 дата публикации

Pathogen and particle detector system and method

Номер: US20120147370A1
Автор: Jian-Ping Jiang, John Babico, Michael Morrell
Принадлежит: Biovigilant Systems Inc

A particle detector has a sample area of cross section no in excess of about 2 mm for containing environmental fluid, a light source on one side of the sample area for directing a collimated or nearly collimated beam of light through the sample air or water so that part of the light beam will be scattered by any particles present in the air or water while the remainder remains unscattered, and a beam diverting device on the opposite side of the sample area for diverting or blocking at least the unscattered portion of the beam of light and directing at least part of the scattered light onto a detector. The detector produces output pulses in which each pulse has a height proportional to particle size and a pulse height discriminator obtains the size distribution of airborne particles detected in the air or water sample at a given time from the detector output. The detector may also include a device for discriminating between biological agents and inorganic particles.

Подробнее
Номер записи: 10
21-06-2012 дата публикации

Liquid feeding system for microchip, sample detection device, and liquid feeding method for liquid feeding system for microchip

Номер: US20120156800A1
Автор: Kusunoki Higashino, Naoki Hikage, Youichi Aoki
Принадлежит: KONICA MINOLTA INC

A liquid feeding system for a microchip performs: a first liquid feeding step in which a sample liquid in a sample liquid containing section is fed in the direction to a primary containing section via a reaction field; a second liquid feeding step in which, after the first liquid feeding step, the sample liquid is fed from the primary containing section in the direction to the reaction field; and a third liquid feeding step in which, after the second liquid feeding step, the feedings of the sample liquid from and to the reaction field and the primary containing section a rear side gas-liquid boundary face of the sample liquid in the first liquid feeding step and the front side and rear side gas-liquid boundary faces of the sample liquid in the second and third liquid feeding steps do not pass through the reaction field.

Подробнее
Номер записи: 11
28-06-2012 дата публикации

Apparatus and method for measuring transmittance

Номер: US20120162651A1
Автор: James Andrew Glover
Принадлежит: Real Tech Inc

A device to measure the amount of light able to transmit through a liquid. The device uses a light detector and light source mounted to a support mechanism such that the detector and light source define a path of light emitted by the light source and detected by the detector. The device uses a structure designed to surround a liquid to be tested such that the structure allows light to transmit through the structure and the liquid. An actuator engenders relative motion between the support mechanism and the structure such that at certain times the light propagating between the light source and the detector passes substantially through the structure and the liquid to be tested such that the amount of light able to transmit through the liquid is detected by the detector, and at other times the light propagates directly from the light source to the detector without passing through the structure or the liquid such that the amount of light emitted from the light source is directly detected by the detector. A microprocessor then uses the two sets of detector readings to allow the transmittance measurement of the liquid to be compensated for errors introduced by drift and fluctuations in the amount of light emitted by the light source and also by drift in the light detector and electronics. Such fluctuation and drift is very common in light sources and is due primarily to changes in temperature and imperfections in the light source itself and the power supply.

Подробнее
Номер записи: 12
02-08-2012 дата публикации

Process analyzer

Номер: US20120195799A1
Автор: Aria Farjam, Bas De Heij, Kai Berggold, Rolf Uthemann, Ulrich Lundgreen
Принадлежит: HACH LANGE GMBH

A process analyzer for detection of an analyte in a liquid under analysis includes a base module and an exchangeable cartridge module. The exchangeable cartridge module comprises a sample taking device comprising a membrane configured to obtain a sample from the liquid under analysis. A first pump mechanism is configured to pump the sample away from the sample taking device. A second pump mechanism is configured to introduce a reagent into the sample. A measuring section is configured to perform a quantitative detection of the analyte in the sample. A degassing device is arranged downstream of the first pump mechanism and the second pump mechanism. The degassing device is configured to degas the sample.

Подробнее
Номер записи: 13
02-08-2012 дата публикации

Three-dimensional (3d) hydrodynamic focusing using a microfluidic device

Номер: US20120196314A1
Автор: Ahmad Ahsan Nawaz, Tony Jun Huang, Xiaole Mao
Принадлежит: PENN STATE RESEARCH FOUNDATION

A microfluidic device comprises inlets for a sample flow and an out-of-plane focusing sheath flow, and a curved channel section configured to receive the sample flow and out-of-plane focusing sheath and to provide hydrodynamic focusing of the sample flow in an out-of-plane direction, the out-of-plane direction being normal to a plane including the curved channel. Examples of the invention also include improved flow cytometers.

Подробнее
Номер записи: 14
16-08-2012 дата публикации

Method and Apparatus for the Optical Determination of Total Organic Carbon in Aqueous Streams

Номер: US20120205547A1
Автор: Chris J. Russo, Don Jackson, Gary P. Klinkhammer, Paul H. Mcclelland
Принадлежит: ZAPS Tech Inc

A method and apparatus for the measurement of total organic carbon content in an aqueous stream is disclosed. Absorbance of electromagnetic energy by the aqueous stream is measured in an optical sample cell with pulsed light at a wavelength of 190 nm±10 nm. A value of total organic carbon from the measured absorbance is calculated without absorbance or fluorescence measurement at any other wavelength.

Подробнее
Номер записи: 15
16-08-2012 дата публикации

Systems and Methods for Detection and Quantitation of Analytes Using an Oscillating Stimulus

Номер: US20120208283A1
Автор: Cristina Polonschii, Dumitru Bratu, Eugen Gheorghiu, Mihai Sorin DAVID
Принадлежит: Centrul International de Biodinamica

Described systems and methods allow the detection of and determination of a concentration of a target analyte such as a biological cell, a virus, a polypeptide, a toxin, a pesticide, a drug, a drug residue, or a DNA strand, in a fluid sample. A variable stimulus, such as an oscillating magnetic field or a light beam of oscillating intensity, is applied to the sample, inducing variations in a position or shape of a constituent of the sample, or variations in a fluorescence of the sample. Such variations produce measurable variations in electric and/or optical properties of a sensor, variations which allow the determination of the concentration of the target analyte.

Подробнее
Номер записи: 16
20-09-2012 дата публикации

Apparatus for detecting target molecules and related methods

Номер: US20120234393A1
Автор: Axel Scherer, George Maltezos, Jeremy Witzens
Принадлежит: California Institute of Technology CalTech

An apparatus for analysis of a sample and in particular of a biological sample. The apparatus contains a microfluidic chip with dies, adapted to be selectively activated or deactivated by presence of target molecules in the biological sample. The apparatus further contains a light source to emit light for illumination of the microfluidic chip and an optical filter to allow passage of the light from the dies once activated or deactivated by the presence of the target molecules. A method for pressurizing a microfluidic chip is also disclosed, where a chamber is provided, the chamber is connected with the microfluidic chip and pressure is applied to the chamber.

Подробнее
Номер записи: 17
20-09-2012 дата публикации

Antigen Binding Proteins

Номер: US20120237506A1
Автор: Birgit Bossenmaier, Christian Klein, Claudio Sustmann, Hubert Kettenberger, Joerg-Thomas Regula, Klaus-Peter Kuenkele, Manfred Schwaiger, Wolfgang Schaefer
Принадлежит: Hoffmann La Roche Inc

The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said antigen binding proteins, and uses thereof.

Подробнее
Номер записи: 18
27-09-2012 дата публикации

System for and Method of Performing Multi-Technique Imaging

Номер: US20120241596A1
Автор: Cagri A. Savran, Khalid M. Arif
Принадлежит: PURDUE RESEARCH FOUNDATION

A system for and method of performing multi-technique imaging are disclosed. Such multi-technique imaging system includes a surface for supporting a specimen and at least two illumination sources for producing light radiation. The system also includes a plurality of reflective and refractive devices arranged to direct at least part of the light radiation from each of the at least two illumination sources to the surface such that the at least part of the light radiation from each of the at least two illumination sources illuminates substantially the same area on the surface. The system also includes a sensor configured to receive light radiation from the at least two illumination sources reflected by the specimen and/or that pass by the specimen. The system also includes a power source configured to power the at least two illumination sources and the sensor.

Подробнее
Номер записи: 19
27-09-2012 дата публикации

Method and system for interaction analysis

Номер: US20120244637A1
Автор: Olof Karlsson
Принадлежит: GE Healthcare Bio Sciences AB

A method of determining one or more interaction parameters for the interaction between an analyte and a ligand using a biosensor, which comprises the steps of: A: providing a sensor surface having the ligand immobilized thereto, B: contacting the sensor surface with a control analyte, C: registering the sensor response from binding of the control analyte to binding sites of the ligand, D: determining the control saturation response (R maxC ) for the interaction between the control analyte and the ligand, E: transforming the control saturation response (R maxC ) to an analyte saturation response (R maxA ) using the relative molar response contribution of the analyte and the control analyte. F: contacting the sensor surface with one or more samples containing different concentrations of the analyte, G: registering the sensor response from binding of the analyte to the binding sites, and H: fitting the registered sensor response to a predetermined interaction model using the analyte saturation response (R maxA ) to determine the interaction parameters.

Подробнее
Номер записи: 20
08-11-2012 дата публикации

Fluorescence detecting optical system and multi-channel fluorescence detection apparatus including the same

Номер: US20120280143A1
Автор: Joon-Ho Kim, Kak Namkoong, Kyung-Ho Kim, Won-Seok Chung
Принадлежит: SAMSUNG ELECTRONICS CO LTD

A fluorescence detection optical system detects fluorescence beams with two or more different wavelengths and maintains a focal position through an automatic focusing function. A multi-channel fluorescence detection apparatus includes the fluorescence detection optical system. The fluorescence detection optical system includes an automatic focusing unit which receives light reflected off a microfluidic device and determines a focal point by using an astigmatic method or a knife edge method, and an actuator which adjusts a position of an objective lens according to control of the automatic focusing unit. In addition, the fluorescence detection optical system may include a plurality of dual band pass filters, dichroic devices, etc., which provide light beams emitted from at least two light sources and transfer fluorescence generated from the microfluidic device to a photodetector.

Подробнее
Номер записи: 21
08-11-2012 дата публикации

Microfluidic device comprising microchannel where protrusions are formed on bottom surface

Номер: US20120282625A1
Автор: Dae Sung Hur, Eun Hee Park, Jae Jeong Kim, Jong Hyun Oh
Принадлежит: Nanoentek Inc

Disclosed is a microfluidic device comprising a microchannel through which fluid can flow. Protrusions are formed on the bottom surface of the microchannel. The microfluidic device increases detection sensitivity by improving optical characteristics and enhances the reactivity of biochemical reaction by slowing down the velocity of fluid flowing inside the microchannel.

Подробнее
Номер записи: 22
03-01-2013 дата публикации

Gas concentration calculation device and gas concentration measurement module

Номер: US20130003046A1
Автор: Tadayoshi Murakami, Toshiyuki Izawa
Принадлежит: Hamamatsu Photonics KK

A device includes a gas cell ( 10 X) configured to form an introduction space ( 11 X) into which a target gas is introduced, an infrared light source ( 20 X) disposed at one end of the gas cell ( 10 X), a modulation mirror ( 70 X) disposed at one end of the gas cell ( 10 X) and configured to reflect or transmit light emitted from the infrared light source ( 20 X), a reflecting mirror ( 60 X) configured to reflect light transmitted through the modulation mirror ( 70 X), a saturated gas chamber ( 40 X), in which a predetermined comparison gas is hermetically enclosed, disposed on an optical path of light transmitted through the modulation mirror ( 70 X), a light receiving unit ( 30 X) disposed at the other end of the gas cell ( 10 X) and configured to receive light reflected by the modulation mirror ( 70 X) and light transmitted through the modulation mirror ( 70 X) and reflected by the reflecting mirror ( 60 X) through the saturated gas chamber ( 40 X), and a calculation circuit ( 3 X) configured to calculate the concentration of the target gas based on received light energy values of the light receiving unit ( 30 X) in each case in which light is reflected or transmitted by the modulation mirror ( 70 X).

Подробнее
Номер записи: 23
17-01-2013 дата публикации

Immersion probe using ultraviolet and infrared radiation for multi-phase flow analysis

Номер: US20130016336A1
Автор: Cheng-Gang Xie
Принадлежит: Schlumberger Technology Corp

A system and method for determining characteristics of a multiphase flow in a well/pipe are disclosed. The disclosed system and method use an optical immersion probe including a flow gap across which two or more types of radiation are transmitted in order to measure absorptions of two or more substances within the multiphase flow. Primarily, broadband ultraviolet (UV) and/or near infrared radiations (NIR) are utilized with the probe to gather absorption data at and/or around at least one of the water peaks and at and/or around one or more oil or oil-condensate peaks. This data may be utilized to calculate the water-cut of the multiphase flow over a wider range of gas volume fractions. Additionally, pressure ports having pressure sensors being located on the optical immersion probe for determining the impact pressures and flow rates of different phases of the multiphase flow may also be used.

Подробнее
Номер записи: 24
31-01-2013 дата публикации

Plasmon sensor, and usage method and manufacturing method thereof

Номер: US20130029430A1
Автор: Hiroaki Oka, Hiroshi Kagata, Masaya Tamura, Susumu Fukushima
Принадлежит: Panasonic Corp

A plasmon sensor has a first metal layer and a second metal layer. The first metal layer has a bottom surface and a top surface configured to be supplied with an electromagnetic wave. The second metal layer has a top surface confronting the bottom surface of the first metal layer. Between the first metal layer and the second metal layer, there is provided a hollow region configured to be filled with a specimen containing a medium. Analyte capturing bodies are physically adsorbed at least one of below the first metal layer and above the second metal layer.

Подробнее
Номер записи: 25
21-02-2013 дата публикации

Fluidic Coupler Assembly With Conical Ferrule

Номер: US20130043672A1
Автор: Anthony C. Jeannotte, Charles T. Murphy, John A. Leason
Принадлежит: Waters Technologies Corp

A fluidic coupler assembly ( 10 ) for use in a light-guided flow cell comprises a coupler body ( 12 ) having a sealing face ( 10 a ), a tubular insert such as an optical fibre ( 16 ) passing through a through bore ( 14 ) of the coupler body and through a ferrule ( 18 ) located adjacent the sealing face of the coupler body. A backing plug ( 20 ) holds the ferrule in position within the coupler body.

Подробнее
Номер записи: 26
07-03-2013 дата публикации

Sensor system using a hollow waveguide

Номер: US20130058830A1
Автор: Andrei Deev, Sheng Wu, Yongchun Tang
Принадлежит: GEOISOCHEM CORP

The present application provides a method for determining one or two parameters of a sensor system for detecting a gaseous sample. The sensor system comprises a light source to generate a light beam, a hollow waveguide to receive the light beam and the gaseous sample, and a detector to detect an absorption peak of the gaseous sample, where the length and inner diameter of the hollow waveguide satisfy relationships as disclosed herein.

Подробнее
Номер записи: 27
14-03-2013 дата публикации

Flow cell for measuring electromagnetic radiation absorption spectra in a continuously flowing immiscible liquid(s) or liquids with entrained gas phases

Номер: US20130061657A1
Автор: Alexey Leonidovich Moskvin, Andrey Vladimirovich Zinenkov, Arkady Samuilovich Dykman, Lubov Borisovna Drozdova, Mark Erik Nelson
Принадлежит: SABIC INNOVATIVE PLASTICS IP BV

An apparatus and method for spectral analysis of immiscible phases are disclosed. A flow cell for online absorption measurements of immiscible process phases can comprise: a body containing an inlet window and an outlet window in operable communication with a measurement instrument; and a series of partitions that divide the inside of the flow cell into three (3) or more vessels that have an inlet and an outlet, wherein the vessels are connected in series with one another. Optionally, the first vessel is equipped with a porous membrane to facilitate the separation of immiscible process phases.

Подробнее
Номер записи: 28
21-03-2013 дата публикации

Waveguide-based optical scanning systems

Номер: US20130071850A1
Автор: Reuven Duer
Принадлежит: PLC Diagnostics Inc

A scanning sensor system, methods of use and kits for detecting a biologically active analyte are provided. The scanning senor system includes a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector.

Подробнее
Номер записи: 29
28-03-2013 дата публикации

Preparation of microfluidic device on metal nanoparticle coated surface, and use thereof for nucleic acid detection

Номер: US20130078740A1
Автор: Benjamin L. Miller, Hsin-I Peng
Принадлежит: UNIVERSITY OF ROCHESTER

The invention relates to a microfluidic device that utilizes nucleic acid-based detection and a detection system containing the same, as well as a process for preparing the micro fluidic device and for using the same to detect the presence of a target nucleic acid molecule in a sample.

Подробнее
Номер записи: 30
25-04-2013 дата публикации

INTEGRATED PLASMONIC SENSING DEVICE AND APPARATUS

Номер: US20130100454A1
Автор: WALTERS Robert Joseph
Принадлежит: Integrated Plasmonics Corporation

An integrated plasmonic sensing device is monolithically integrated and provides marker-free detection (eliminating the need to use fluorescent or absorbing markers) and in-situ monitoring of conditions at each detection region. The integrated plasmonic sensing device includes a plasmonic backplane disposed on a monolithically integrated image sensor. One or more plasmonic scattering regions and one or more plasmonic via regions laterally offset from the plasmonic scattering regions are provided in the plasmonic sensing device. Guided plasmonic modes mediate power transfer through the plasmonic backplane to one or more underlying image sensor pixels. 1. A sensor comprising:a plurality of measurement regions supporting changes in surface plasmon excitation in response to incident light at each measurement region,a plurality of photodetectors, with each photodetector connected to one or more measurement regions by plasmon vias capable of supporting guided plasmons, andwherein the plurality of measurement regions and plurality of photodetectors are monolithically integrated and together form an integrated sensor capable of producing electrical signals in response to molecular recognition events at each measurement region.2. A sensor in accordance with wherein the plurality of photodetectors together comprise an image sensor formed in a semiconductor substrate and the plurality of measurement regions form part of a plasmonic backplane located between a fluid chamber and the plurality of photodetectors.3. A sensor in accordance with wherein more than one of the plurality of photodetectors are connected to one of the plurality of measurement regions by one or more plasmon vias.4. A sensor in accordance with wherein more than one of the plurality of measurement regions are connected to one of the plurality of photodetectors by one or more plasmon vias.5. A sensor in accordance with wherein at least some of the plurality of measurement regions are laterally offset from and ...

Подробнее
Номер записи: 31
16-05-2013 дата публикации

Optical phase device, method and system

Номер: US20130120750A1
Автор: Guan Jingyi, Lv Zhiting, Wan Yuhang, ZHAO XIN, Zheng Zheng
Принадлежит: BEIHANG UNIVERSITY

The invention provides an optical phase device with its application method and system. The optical phase device consists of a transparent dielectric substrate, a multilayer stack of dielectrics and a buffer layer. The refractive index of the transparent dielectric substrate, the multilayer stack of dielectrics and the buffer layer are all larger than that of the external medium. For the wavelength of the incident beam, the optical phase device has a phase variation in the angular range [α, β] and the critical angle for total reflection on the interface between the buffer layer and the external medium adjacent to the buffer layer is γ, γ>β. Our invention of the optical device has both low loss and large phase variation, which leads to a large Goos-Hanchen shift. As a dispersion compensation component, it can produce bigger and tunable dispersion, and different dispersion compensations can be got by adjusting the operating angle or parameters in the structure.

Подробнее
Номер записи: 32
06-06-2013 дата публикации

Spfs sensor equipped with mechanism purifying non-specifically adsorptive contaminants

Номер: US20130143332A1
Автор: Masanori Tsukagoshi, Noriaki Yamamoto, Takatoshi KAYA
Принадлежит: KONICA MINOLTA INC

[Object] It is an object of the invention to provide a sensor area which can suppress a decrease in assay signal and an increase in assay blank in an SPFS measurement. [Solution] An SPFS sensor chip of the invention includes a purification area and a sensor area arranged upstream and downstream, respectively, relative to each other along a flow direction in a channel for surface plasmon-field enhanced fluorescence spectroscopy [SPFS].

Подробнее
Номер записи: 33
27-06-2013 дата публикации

PLASMON SENSOR

Номер: US20130163001A1
Автор: Hashimotodani Kiyoshi, Kagata Hiroshi, Tamura Masaya
Принадлежит: Panasonic Corporation

A plasmon sensor includes a supporter, a first metal layer on a lower surface of the first supporter, and a second metal layer having an upper surface facing a lower surface of the first metal layer. A hollow space is provided between the first and second metal layers, and is configured to be filled with a test sample containing a medium. The area of the first metal layer is smaller than the area of the upper surface of the supporter. The supporter has a region having hydrophilic property and facing and contacting the hollow space. This the plasmon sensor has a small size and a simple structure. 1. A plasmon sensor comprising:a first supporter having a lower surface;a second supporter having an upper surface;a first metal layer having a lower surface and an upper surface which is configured to receive electromagnetic wave and disposed on the lower surface of the first supporter; anda second metal layer having a lower surface and an upper surface which faces the lower surface of the first metal layer, the lower surface of the second metal layer being disposed on the upper surface of the second supporter,wherein a hollow space is provided between the first metal layer and the second metal layer, and is configured to be filled with a test sample containing a medium,wherein one of the first supporter and the second supporter has hydrophilic property,wherein an area of the first metal layer is smaller than an area of the lower surface of the first supporter in a case that the first supporter has hydrophilic property, andwherein an area of the second metal layer is smaller than an area of the upper surface of the second supporter in a case that the second supporter has hydrophilic property.2. The plasmon sensor according to claim 1 ,wherein the lower surface of the first supporter has a first region facing the hollow space in a case that the first supporter has hydrophilic property, andwherein the upper surface of the second supporter has a second region facing the hollow ...

Подробнее
Номер записи: 34
04-07-2013 дата публикации

Versatile surface plasmon resonance analyzer with an integral surface plasmon resonance enhanced fluorescence mode

Номер: US20130169954A1
Автор: Ernest F. Guignon, George N. Gibson, Michael T. Reilly
Принадлежит: Ciencia Inc

An instrument for measuring and analyzing surface plasmon resonance on a sensor surface has a polarized light source optically connected to the sensor surface by a plurality of optical elements, including in one embodiment an optical telescope that transfers light from a rotatable reflecting surface to the sensor surface. Selective positioning of a cylindrical lens into a first position within the path of light transforms collimated light to a rectangular wedge that is incident upon the sensor surface at numerous angles. In another embodiment, the light source is operated as a laser to excite fluorescence on the sensor surface and the fluorescence is selectively directed to a detector by appropriate optical elements positioned in specific configurations.

Подробнее
Номер записи: 35
25-07-2013 дата публикации

OPTICAL BIOSENSOR REFERENCING METHOD

Номер: US20130189797A1
Автор: Quinn John Gerard
Принадлежит: FLIR SYSTEMS, INC.

A referencing method for an optical biosensor system using a single sensing region is provided. The method involves limiting the ligand immobilized in a single sensing region to only a portion thereof. In one embodiment, this is accomplished by selectively deactivating a portion of the sensing surface to prevent immobilization of ligand to that portion. As a result, a reference response can be recorded in the same sensing region as a molecular interaction response. Thus, the bulk refractive index can be accurately accounted for in measuring the kinetics of a molecular interaction. 1. A method for providing a reference bulk refractive index response and a binding response in a sensing region defined along a channel in a flow cell of a biosensor system comprising the steps of:injecting a first sample through a first input port at a first end of the sensing region wherein a second exit port at a second end of the sensing region is open and a first exit port at the first end of the sensing region is closed such that the first sample is caused to flow from the first end of the sensing region to the second end of the sensing region, wherein the first sample comprises an activating agent sufficient to permit immobilization of a ligand;terminating the injection of the first sample;injecting a second sample at a flow rate through the first input port, wherein the first exit port is opened and the second exit port is closed;modifying the flow rate of the second sample in a manner sufficient to cause the second sample to contact a first portion of the sensing region thereby defining a second portion of the sensing region that is not contacted by the second sample, wherein the second sample comprises a deactivating agent sufficient to render the first portion unable to immobilize the ligand;terminating the injection of the second sample;injecting a third sample comprising a ligand through the first input port with the second exit port open and the first exit port closed such ...

Подробнее
Номер записи: 36
29-08-2013 дата публикации

Microbubble optical resonator

Номер: US20130219970A1
Автор: Mikhail Sumetsky
Принадлежит: OFS FITEL LLC

An optical microresonator is configured as an optical microbubble formed along a section of an optical microcapillary. The curvature of the outer surface of the microbubble creates an optical resonator with a geometry that encourages the circulating WGMs to remain confined in the central region of the bubble, creating a high Q optical resonator. The resonator may be tuned by modifying the physical properties of the microbubble, allowing the resonator to be used as an optical filter. The resonator may also be used as a sensor or laser by introducing the material to be sensed (or the active laser material) into the microcapillary along which the microbubble is formed.

Подробнее
Номер записи: 37
29-08-2013 дата публикации

Spectrophotometer

Номер: US20130222789A1
Автор: Hideyuki Akiyama, Shigeru Matsui, Shuhei Yamamura, Yoshisada Ebata
Принадлежит: Hitachi High Technologies Corp

In a spectrophotometer of the single-beam type, highly stable transmission and absorption spectra can be obtained with a high SNR while drifting is suppressed and for a long time even when the amount of light from the light source is varied over time. The spectrophotometer includes: a light source; a sample cell; a polychromator that generates a transmission spectrum of a sample in the sample cell by dispersing a portion of light from the light source that has passed through the sample into a plurality of spectral components; an image sensor that detects the transmission spectrum of the sample; a light source monitoring photodetector that detects a portion of the light from the light source that has not passed through the sample cell; and an operation unit that corrects the transmission spectrum of the sample by using an output signal from the light source monitoring photodetector.

Подробнее
Номер записи: 38
12-09-2013 дата публикации

DIAGNOSTIC INSTRUMENT AND FLOW PROCESS

Номер: US20130234053A1
Автор: Thomas Michael A, Thomas Richard A
Принадлежит: BECKMAN COULTER BIOMEDICAL, LLC.

A diagnostic instrument is disclosed. The diagnostic instrument may have a highly efficient probe washer station and/or may be able to sense whether there is a tube septum on a specimen tube to be sampled. The instrument may also be able to determine where the bottom of the tube is located. The probe washer station may have a flow of saline that is used to wash both the internal cavity and the external circumference of the probe. 120.-. (canceled)21. A flow cytometer comprising:a laser beam positioned to excite sample particles in a sensing zone;an aperture that directs a flow of the sample particles through the sensing zone where the sample particles are interrogated by the laser beam, the aperture having a cross-sectional size; anda flow cytometer filtration system including a filter having multiple holes with cross sectional sizes that are less than or equal to the cross-sectional size of the aperture, wherein the filter is located in an area of the flow cytometer having a fluid velocity of less than 200 microliters per minute.22. The flow cytometer of claim 21 , further comprising a sample injector located in the area of the flow cytometer having a fluid velocity of less than 200 microliters per minute.23. The flow cytometer of claim 22 , further comprising a backflushing system claim 22 , wherein the filter is positioned in the flow cytometer at a location where the filter can be back flushed at a high fluid velocity of greater than 200 microliters per minute.24. The flow cytometer of claim 23 , wherein the backflushing system further comprises an automatic clog detecting system.25. The flow cytometer of claim 21 , wherein the aperture has a cross sectional shape selected from: a square claim 21 , a rectangle claim 21 , and an equilateral triangle.26. The flow cytometer of claim 25 , wherein the cross-sectional size of the aperture is from 100 to 300 microns per side.27. The flow cytometer of claim 26 , wherein the aperture has a length greater than 1000 ...

Подробнее
Номер записи: 39
19-09-2013 дата публикации

Polymeric device suitable for ultraviolet detection

Номер: US20130240747A1
Автор: Hanno Ehring
Принадлежит: GE Healthcare Bio Sciences AB

The present invention relates to a flow cell ( 10 ) comprising a fluid inlet ( 16 ) and a fluid outlet ( 18 ) separated by a sample flow-through chamber ( 12 ) comprising at least one UV-transparent window ( 22 ′), wherein the at least one UV-transparent window ( 22 ′) is made of a polymer material and has been subjected to Gamma radiation sterilisation. In one aspect, the flow cell is combustible.

Подробнее
Номер записи: 40
19-09-2013 дата публикации

Device for Reading Assay Results on Test Carrier

Номер: US20130242308A1
Автор: "Zhan Yingan", Gao Fei, Liu Wei, Wu Yinfei
Принадлежит: ABON Biopharm (Hangzhou)Co., Ltd.

A device for reading an assay test result on a test carrier comprises: a light-emitting element () for emitting and irradiating light onto corresponding one or more zones of the test carrier (); a light-blocking element () for blocking the light mirror-reflected by the test carrier () from being irradiated on a photodetector (); and a window (), through which the light emitted from the light-emitting element () is irradiated onto the corresponding zones of the test carrier (). In one preferred embodiment, the positions of the light-emitting element (), the light-blocking element and the window () meet the function of S*S−S*SS where S represents the vertical distance between the light-emitting element and the window; S represents the vertical height of the light-blocking element; S represents the vertical distance between the light-blocking element and the light-emitting element; and S represents the length of the window. 1. A device for reading an assay test result on a test carrier , comprising:a light-emitting element, for emitting and irradiating light onto corresponding one or more zones of the test carrier; anda light-blocking element, for blocking the light mirror-reflected by the test carrier from being irradiated on a photodetector.2. The device according to claim 1 , wherein the device further comprises a window through which the light emitted from the light-emitting element is irradiated onto the test carrier.3377211237. The device according to claim 2 , wherein positions of the light-emitting element claim 2 , the light-blocking element and the window meet a function of S≧2×S−S×S÷S claim 2 , where S represents a vertical distance between the light-emitting element and the window; S represents a vertical height of the light-blocking element; S represents a vertical distance between the light-blocking element and the light-emitting element; and S represents a length of the window.437721. The device according to claim 3 , wherein the positions of the light- ...

Подробнее
Номер записи: 41
24-10-2013 дата публикации

Flow cells for high density array chips

Номер: US20130281305A1
Автор: Anthony Delacruz, Bill J. Peck, Daniel West, Mark Fuller
Принадлежит: Complete Genomics Inc

Biochemical flow cells having sealed inlets and outlets are provided for performing high-volume assays on macromolecules. In one example embodiment, a flow cell with detachable inlet and outlet connectors comprises an inlet manifold, a coverslip, and a substrate disposed below the coverslip to form a reaction chamber, where the substrate is disposed to partially cover the inlet manifold such that a slit is formed along an entire edge of the substrate where fluids can flow from the inlet manifold through the slit, around substantially the entire edge of the substrate, and into the reaction chamber at equalized pressure and without bubbles. In another embodiment, a flow cell comprises an outlet manifold, two or more flow regions each connected to its own loading port via its own flow distribution funnel, each loading port connected to the outlet manifold, and plugs in a wall of the outlet manifold opposite each loading port, such that when a plug is absent from the wall of the outlet manifold, a loading tip may be inserted in its place, passing through the outlet manifold and connecting directly to a loading port.

Подробнее
Номер записи: 42
07-11-2013 дата публикации

Interactive variable pathlength device

Номер: US20130293894A1
Автор: Craig Harrison, I-Tsung Shih, Mark Salerno
Принадлежит: Craig Harrison, I-Tsung Shih, Mark Salerno

This disclosure relates generally to a sampling device, and more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software controlled algorithms and methods for such a device.

Подробнее
Номер записи: 43
07-11-2013 дата публикации

Sensing Device

Номер: US20130293896A1
Автор: Akiyama Shoji, Fujimaki Makoto, Nagata Kazutoshi
Принадлежит:

[Problem] To provide a small-sized, stable, and highly sensitive detection device by achieving an optical system which is the most suitable for an optical waveguide mode sensor using a spectral measurement method. 1. A detection device , comprising:a detection plate in which a silicon layer and a silicon oxide layer are arranged in this order on a silica glass substrate;an optical prism which is optically adhered to a surface of the silica glass substrate of the detection plate, where the surface is not provided with the silicon layer and the silicon oxide layer;a light-irradiation unit configured to irradiate light to the detection plate through the optical prism and arranged so that light is incident on the optical prism with a fixed incident angle; anda light-detection unit configured to detect intensity of reflected light reflected from the detection plate,wherein the detection device detects a change in dielectric constant in the proximity of the surface of the silicon oxide layer of the detection plate by detecting a change in property of the reflected light, andwherein in the optical prism, an angle between an incident surface on which light irradiated from the light-irradiation unit is incident and an adhesion surface which adheres to the detection plate is 43° or less.2. The detection device according to claim 1 , wherein the light-irradiation unit irradiates light in parallel with an in-plane direction of the adhesion surface.3. The detection device according to claim 1 , wherein the silicon layer is formed from single crystal silicon.4. The detection device according to claim 1 , wherein an interface roughness between the silicon layer and the silicon oxide layer is 0.5 nm or less as a RMS value.5. The detection device according to claim 1 , wherein the light-irradiation unit comprises a light source claim 1 , a collimator configured to collimate light irradiated from the light source to form collimated light claim 1 , and a polarizing plate configured to ...

Подробнее
Номер записи: 44
28-11-2013 дата публикации

Test chip and test chip unit incorporated with test chip

Номер: US20130312546A1
Автор: Shigeru Wada
Принадлежит: KONICA MINOLTA INC

The present invention is characterized in being provided with a chip main body, which is provided with a flow channel having the end portion thereof opened in the surface, and a sheet-like sealing member, which brings the inside of the flow channel into a hermetically closed state by covering at least the opening in the surface of the chip main body. The present invention is also characterized in that in the sealing member, a plurality of sheets are laminated, said sheets including a first sheet, which has ductility and elasticity such that the first sheet can be penetrated by means of a nozzle member, and a second sheet having ductility lower than that of the first sheet, the sheets adjacent to each other are bonded with an adhesive agent or a cohesive agent, and that the second sheet is positioned further toward the chip main body side than the first sheet.

Подробнее
Номер записи: 45
12-12-2013 дата публикации

Method of patterning self-organizing material, patterned substrate of self-organizing material and method of producing the same, and photomask using patterned substrate of self-organizing material

Номер: US20130330674A1
Автор: Hitoshi Tabata, Ken-Ichiro Nakamatsu, Shinji Matsui, Tomoji Kawai, Toshihito Ohtake
Принадлежит: Individual

A method for performing micro fabrication includes using, as a photomask, a self-organizing material-patterned substrate which is soluble in an organic solvent. A method for emitting light includes emitting the light in a pattern of a nucleic acid which is a self-organizing material immobilized on a self-organizing material-patterned substrate. An immobilization layer containing a binding material capable of binding to a self-organizing material is formed on a substrate. Then this immobilization layer is patterned by transferring a protrusion and recess pattern formed in a mold thereto by the imprint process. The self-organizing material is supplied onto the side having the protrusion and recess pattern of the immobilization layer transferred thereto. Thus, the self-organizing material is immobilized according to the protrusion and recess pattern of the immobilization layer owning to the self-organizing ability of the material per se and the binding ability of the binding material contained in the immobilization layer.

Подробнее
Номер записи: 46
12-12-2013 дата публикации

SURFACE PLASMON RESONANCE SENSOR

Номер: US20130330838A1
Автор: Lipson Ariel, LIPSON Doron, Lipson Stephen G., Nimri Shay, Notcovich Ariel G., RAN Boaz
Принадлежит: Bio-Rad Laboratories Inc.

An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen. 1. A surface plasmon resonance (SPR) system using a ligand , the system comprising:a) a thin conducting layer suitable for SPR formed on a transparent substrate, the conducting layer comprising a plurality of electrodes;b) at least one flow channel crossing the electrodes at crossover regions;c) a power supply connected to the electrodes, and differently electrifying the electrodes at two different cross-over regions, such that the ligand flowing through the flow channel is attracted to and immobilized on the electrode at one of the cross-over regions, and repelled by and substantially prevented from immobilizing on the electrode at the other of the cross-over regions; andd) a photosensitive surface that generates SPR signals in response to light reflected from the crossover region at which the ligand is immobilized, that can be used to determine an SPR parameter, and generates reference SPR signals in response to light reflected from the crossover region at which the ligand is prevented from immobilizing, that can be used to normalize and correct the SPR signals from the crossover region at which the ligand is immobilized.2. A system according to ...

Подробнее
Номер записи: 47
19-12-2013 дата публикации

Large area, low f-number optical system

Номер: US20130334407A1
Автор: Donald Francis Perrault, JR., Johnathan Charles Sharpe
Принадлежит: Cytonome ST LLC

Large area, low f-number optical systems, and microfluidic systems incorporating such optical systems, are disclosed. Large area, low f-number optical systems may be used to collect light from plurality of micro channels associated with a plurality of flow cytometers. The optical systems may be configured to collect light from a source area having an object lateral length or width within a range of 25 mm and 75 mm, configured to have an f-number within a range of 0.9 to 1.2, and configured to have a working distance within a range of 10 mm to 30 mm.

Подробнее
Номер записи: 48
26-12-2013 дата публикации

Sealed fluidic component comprising a composite material of different paek materials

Номер: US20130341260A1
Автор: Bernhard Dehmer
Принадлежит: AGILENT TECHNOLOGIES INC

A sealed fluidic component ( 280 ) for use in a fluidic flow path is made by providing a composite material ( 300 ) comprising a first material ( 305 ) and a second material ( 310 ), wherein the first material ( 305 ) and the second material ( 310 ) are different PAEK materials with the first material ( 305 ) having a lower melting point than the second material ( 310 ). The composite material ( 300 ) is heated in order to provide a sealing by the first material ( 305 ).

Подробнее
Номер записи: 49
26-12-2013 дата публикации

NON-SCANNING SPR SYSTEM

Номер: US20130344623A1
Автор: Barak Itay, RAN Boaz
Принадлежит: Bio-Rad Laboratories Inc.

A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: 2. A system according to claim 1 , wherein the detector comprises a plurality of detector elements claim 1 , arranged on the detector in a one-dimensional array claim 1 , and the different responses of the detector to light received at different locations is due to a different response of the detector to light received by different detector elements.3. A system according to claim 1 , wherein the evanescent wave phenomenon comprises surface plasmon resonance (SPR) claim 1 , and the sample surface comprises a material that exhibits SPR.4. A system according to claim 1 , wherein the illumination sub-system is configured to illuminate all sensing areas of interest simultaneously.5. A system according to claim 1 , wherein claim 1 , for each sensing area of interest claim 1 , the illumination sub-system is configured to illuminate said sensing area of interest over the entire range of angles of incidence simultaneously.6. A system according to claim 1 , wherein the detector comprises a plurality of detector elements claim 1 , and the different response of the detector to light received at different locations is due to a different response of the detector to light received by different detector elements.7. A system according to claim 6 , configured so that light reflected from each sensing area of interest claim 6 , at different angles of incidence in the range for that area claim 6 , is received by the elements of the detector with substantially different distributions of intensities claim 6 , thereby making it possible to determine claim 6 , from the response of the detector claim 6 , how much light is reflected from each sensing area of interest claim 6 , as a function of angle of incidence.8. A system according to claim 7 , wherein the projection optics projects light reflected from each sensing area of interest claim 7 , within each of a plurality of sub-ranges of ...

Подробнее
Номер записи: 50
23-01-2014 дата публикации

Rotating stall detection using optical measurement of blade untwist

Номер: US20140023498A1
Автор: Daniel Kominsky
Принадлежит: Prime Photonics LC

Systems and methods are provided for real-time detection of the onset of stall in turbomachinery, such as compressor stall. The methods are capable of detecting and analyzing time of arrival of the chord of the blade at a sensor array to provide an indication of the onset of compressor stall. Systems for detecting the onset of compressor stall include: light sources; a plurality of linearly arranged optical fibers for transmitting light from the light sources and for receiving transmitted light reflected from a blade; a detector for measuring intensity of the reflected light; and a processor for analyzing the intensity of the reflected light to determine blade twist angle and from the blade twist angle identify onset of compressor stall. The invention can prevent the needless loss of life and assets caused by compressor stall that may lead to unexpected catastrophic failure of an engine.

Подробнее
Номер записи: 51
23-01-2014 дата публикации

Flow-channel device for detecting light emission

Номер: US20140024126A1
Автор: Makoto Ogusu
Принадлежит: Canon Inc

The present invention provides a flow-channel device for detecting light emission, which suppresses a noise originating in unnecessary light emission, and can be simply bonded with the use of an organic material. The flow-channel device having a flow channel is structured by the bonding of at least two substrates, wherein at least any one substrate has a first groove which constitutes the flow channel, and a second groove for arranging an adhesive therein which contains an organic material, and a light-shielding layer is provided on an inner wall of the second groove so as to block a light emitted from the second groove from penetrating into the first groove.

Подробнее
Номер записи: 52
13-02-2014 дата публикации

METHOD AND APPARATUS FOR PROVIDING IMAGE DATA FOR CONSTRUCTING AN IMAGE OF A REGION OF A TARGET OBJECT

Номер: US20140043616A1
Автор: Humphry Martin James, Maiden Andrew Michael
Принадлежит: PHASE FOCUS LIMITED

Embodiments of the present invention provide a method () of providing image data for constructing an image of a region of a target object, comprising detecting, by at least one detector (), at least a portion of radiation scattered by a target object () with the incident radiation () or an aperture at a predetermined probe position, determining an offset vector () for reducing an error associated with the probe position (), estimating a wavefront () based on a probe function having the offset vector applied to the probe position, and providing image data responsive to the detected radiation. 1. A method of providing image data for constructing an image of a region of a target object , comprising:detecting, by at least one detector, at least a portion of radiation scattered by the target object with the incident radiation or an aperture at a predetermined probe position;determining an offset vector for reducing an error associated with the probe position;estimating a wavefront based on a probe function having the offset vector applied to the probe position; andproviding image data responsive to the detected radiation.2. The method of claim 1 , comprising:updating a current best offset vector associated with the probe position when a current best error metric associated with the probe position is improved.3. The method of claim 2 , wherein the updating of the current best offset vector comprises:determining an error metric for the offset vector based on a difference between the estimated wavefront and a wavefront corresponding to the radiation detected by the at least one detector; andcomparing the error metric for the offset vector with the current best error metric associated with a current best offset vector for the probe position.4. The method of claim 1 , comprising:determining an offset vector for each of a plurality of probe positions.5. The method of claim 1 , wherein the offset vector is determined in an at least partly random manner.6. The method of claim 1 ...

Подробнее
Номер записи: 53
27-02-2014 дата публикации

DISPOSABLE SENSOR HEAD AND DISPOSABLE CONTAINER

Номер: US20140054186A1
Автор: Grimm Christian, Riechers Daniel
Принадлежит: SARTORIUS STEDIM BIOTECH GMBH

A disposable sensor head for an optical sensor has a central body () with an axial through-channel () closed by a transparent viewing disk () oriented transversely with respect to its longitudinal direction, and a circumferential fastening flange (), by which the central body is fastenable in a sealing fashion on a wall of a flexible container () so that the through-channel () passes through the wall. The through-channel () forms in one section an open flow chamber () that is bounded on one side by the viewing disk () and on the other side by a reflector disk () arranged opposite the viewing disk (). 112. A disposable sensor head for an optical sensor , comprising a central body () having{'b': 20', '14, 'an axial through-channel () closed by a transparent viewing disk () oriented transversely with respect to its longitudinal direction, and'}{'b': 22', '62', '20, 'claim-text': wherein', {'b': 20', '34', '14', '16', '14, 'the through-channel () forms in one section an open flow chamber (), that is bounded on one side by the viewing disk () and on the other side by a reflector disk () arranged opposite the viewing disk ().'}], 'a circumferential fastening flange (), by which the central body is fastenable in a sealing fashion on a wall of a flexible container () in such a way that the through-channel () passes through the wall,'}2. The sensor head of claim 1 ,wherein{'b': 34', '36', '14', '16, 'the flow chamber () comprises at least two lateral openings () arranged between the viewing disk () and the reflector disk ().'}3. The sensor head of claims 1 ,wherein{'b': 12', '14', '16', '25', '40, 'the central body () comprises, on a side of the viewing disk () facing away from the reflector disk (), a coupling device () for reversible coupling of an optoelectronic sensor module ().'}4. The sensor head of claims 1 ,wherein{'b': 12', '18', '24', '26, 'the central body () is constructed in a plurality of parts and comprises a main body () and at least one further central body ...

Подробнее
Номер записи: 54
06-03-2014 дата публикации

FLOW CELL

Номер: US20140063494A1
Автор: HATAHORI Takahide, MORIYA Naoji, NAKAMA Yuji, WADA Yukihisa
Принадлежит:

In a flow cell, where a light introducing member for introducing light for measurement into a linear capillary through which sample liquid flows is attached to one end of the capillary, and a light leading out member for leading light transmitted through the capillary while transmitting through the sample liquid flowing through the capillary out to the outside is attached to the other end, the light introducing member is a light waveguide inserted into the capillary, and the light leading out member is a window member attached to an opening at the other end of the capillary so the loss of the amount of light transmitted through the capillary can be suppressed, while it is possible for flow cells of which the optical path has a different length to be attached without causing a problem relating to the positional relationships in the optical system, such as an absorbance detector. 1. A flow cell , comprising: a linear capillary through which a sample liquid flows; a light introducing member for introducing light for measurement into the capillary , the light introducing member being attached to one end of the capillary; and a light leading out member for leading light that has transmitted through the capillary while transmitting through the sample liquid flowing through the capillary out to the outside , the light leading out member being attached to the other end of the capillary , and being characterized in thatsaid light introducing member is a light waveguide inserted into the capillary through an opening at one end of said capillary, and said light leading out member is a window member attached to an opening at the other end of the capillary.2. The flow cell according to claim 1 , characterized in that said light waveguide is an optical fiber without an outer coating or a quartz cylinder.3. The flow cell according to claim 1 , characterized in that a quartz convex lens is provided in the end portion of said light waveguide on the light source side.4. The flow cell ...

Подробнее
Номер записи: 55
13-03-2014 дата публикации

Microfluidic photoporation

Номер: US20140073027A1
Автор: Frank Gunn-Moore, Kishan Dholakia, Robert Marchington, Yoshihiko Arita
Принадлежит: University of St Andrews

A cell permeabilizing micro fluidic system for permeabilizing one or more cells in a fluid flow. The system has a micro fluidic channel for channeling at least one cell in a fluid flow and an optical source for generating a beam of light for permeabilizing the at least one cell, wherein the channel and the source are arranged so that the light beam and fluid flow are collinear in a permeabilization part of the channel and cells are permeabilized within the permeabilization part.

Подробнее
Номер записи: 56
20-03-2014 дата публикации

PATHOGEN AND PARTICLE DETECTOR SYSTEM AND METHOD

Номер: US20140078500A1
Автор: Babico John, Jiang Jian-Ping, Morrell Michael
Принадлежит:

A particle detector has a sample area of cross section no in excess of about 2 mm for containing environmental fluid, a light source on one side of the sample area for directing a collimated or nearly collimated beam of light through the sample air or water so that part of the light beam will be scattered by any particles present in the air or water while the remainder remains unscattered, and a beam diverting device on the possible side of the sample area for diverting or blocking at least the unscattered portion of the beam of light and directing at least part of the scattered light onto a detector. The detector produces output pulses in which each pulse has a height proportional to particle size and a pulse height discriminator obtains the size distribution of airborne particles detected in the air or water sample at a given time from the detector output. The detector may also include a device for discriminating between biological agents and inorganic particles. 1. A flow cell for a particle detection apparatus comprising:an inlet in fluid communication with a source of fluid to be measured;an outlet;a fluid moving unit in fluid communication with the outlet;a first channel defined by the flow cell between and in fluid communication with the inlet and the outlet, the channel having a sampling region where particles carried in a fluid from the inlet are measured, anda second channel defined by the flow cell between and in fluid communication with the inlet and the outlet.2. The flow cell of claim 1 , wherein the second channel is arranged substantially parallel to the first channel.3. The flow cell of claim 1 , wherein the sampling region comprises an optical window enabling optical interrogation of particles in the fluid from the inlet.4. The flow cell of claim 1 , wherein the inlet is conical.5. The flow cell of claim 1 , wherein the outlet is conical.6. The flow cell of claim 1 , wherein the second channel connects the inlet to the outlet.7. The flow cell of ...

Подробнее
Номер записи: 57
20-03-2014 дата публикации

Optical sensing device for sensing analytes and related apparatus and methods

Номер: US20140080729A1
Автор: Kristin Hedgepath Gilchrist, Sonia Grego
Принадлежит: Research Triangle Institute International

An optical sensing device and associated apparatus are configured for multiplexed detection of specific analytes in fluid samples. The device has a wavelength-tunable grating-coupler configuration in which a grating is disposed on a surface of a waveguide. Different regions of the grating may be functionalized with different receptors, and may form binding-specific sensors and reference sensors. The receptors are exposed to a fluid sample utilizing a fluidic structure mounted to the device. The device utilizes evanescent waves to sense analytes bound to the waveguide surface. The evanescent wave is sensitive to changes in refractive index at (or near) the waveguide surface. Changes in refractive index occur proportionally to the mass of the bound analyte. The apparatus utilizes a tunable light source to implement swept wavelength interrogation while the input beam is held at a fixed coupling angle relative to the waveguide and grating.

Подробнее
Номер записи: 58
03-01-2019 дата публикации

SAMPLE CELLS FOR RESPIRED GAS SAMPLING AND METHODS OF MANUFACTURING SAME

Номер: US20190000351A1
Автор: SCAMPOLI DAVID
Принадлежит:

A sample cell () for a respired gas sensor has a single-piece injection molded main body () defining a gas flow path including an optical sampling bore (), a gas inlet lumen () connected with the inlet end () of the optical sampling bore, and a gas outlet lumen () connected with the outlet end () of the optical sampling bore. The gas flow path includes at least two curved walls (). The sample cell may be manufactured by assembling mold pins () for defining the gas flow path wherein at least two mold pins () have curved surfaces for defining the at least two curved walls of the gas flow path, and injection molding the single piece injection molded main body including removing the mold pins after defining the gas flow path including the at least two curved walls. 1. A sample cell for a respired gas sensor , the sample cell comprising:a single-piece injection molded main body defining a gas flow path including (i) an optical sampling bore with opposite inlet and outlet ends, (ii) a gas inlet lumen connected with the inlet end of the optical sampling bore, and (iii) a gas outlet lumen connected with the outlet end of the optical sampling bore;an inlet optical window attached to the single-piece injection molded main body and covering the inlet end of the optical sampling bore; andan outlet optical window attached to the single-piece injection molded main body and covering the outlet end of the optical sampling bore.2. The sample cell of wherein:the inlet optical window seals the inlet end of the optical sampling bore; and the outlet optical window seals the outlet end of the optical sampling bore.3. The sample cell of wherein:the optical sampling bore defines an optical axis,the inlet optical window is oriented transverse to the optical axis, andthe outlet optical window is oriented transverse to the optical axis.4. The sample cell of wherein:the gas inlet lumen and the gas outlet lumen are parallel,the gas inlet lumen is orthogonal to the optical axis, andthe gas ...

Подробнее
Номер записи: 59
01-01-2015 дата публикации

Sample Processing Improvements For Microscopy

Номер: US20150002834A1
Автор: Fine Alan Marc, Hymes-Vandermeulen Noah, Macaulay Hershel
Принадлежит:

Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface. 1. A method comprisingmoving one surface of a microscopy sample chamber to a distance from another surface of the sample chamber that will enable capillary flow of a fluid containing a sample within the chamber, andafter the capillary flow, moving the one surface closer to the other surface to a distance that forces the sample against the other surface for high resolution digital microscopy.2. The method of in which the moving of the surface toward the other surface is controlled automatically.3. The method of comprising ejecting the fluid into the sample chamber before moving the one surface closer to the other surface.4. The method of in which the fluid is ejected automatically.5. The method of in which the moving of the surface toward the other surface is controlled automatically.6. An apparatus comprisinga chamber to contain a fluid sample for use in microscopy, anda mechanism to controllably deliver the sample to a location of the chamber to enable the sample to be drawn across the chamber by capillary action.7. The apparatus of comprising a hydrophilic coating on a wall of the chamber.8. The apparatus of comprising a sensor exposed in the chamber and a hydrophilic hydrophobic coating of areas in the vicinity of the sensor.9. The apparatus of in which the mechanism comprises a feature of the chamber to cooperate with ...

Подробнее
Номер записи: 60
05-01-2017 дата публикации

SHEATH FLUID SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES

Номер: US20170003273A1
Автор: Adams Thomas H., Farrell Gregory A., Groner Warren, Wanders Bart J., Zhao Xiaodong
Принадлежит:

Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. 1. A particle and intracellular organelle alignment liquid (PIOAL) for use in a combined viscosity and geometric hydrofocusing analyzer , the PIOAL directing flow of a blood sample fluid of a given viscosity that is injected into a narrowing flowcell transition zone of the visual analyzer so as to produce a sample fluid stream enveloped by the PIOAL , the PIOAL comprising:a fluid having a higher viscosity than the viscosity of the blood sample fluid,a pH adjusting agent, andProcaine HCl,wherein a viscosity hydrofocusing effect induced by an interaction between the PIOAL fluid and the sample fluid associated with the viscosity difference, in combination with a geometric hydrofocusing effect induced by an interaction between the PIOAL fluid and the sample fluid associated with the narrowing flowcell transition zone, is effective to provide a target imaging state in at least some of the plurality of particles at an imaging site of the visual analyzer while a viscosity agent in the PIOAL retains viability of cells in the sample fluid stream leaving structure and content of the cells intact when the cells extend from the sample fluid stream into the flowing sheath fluid, andwherein the viscosity agent of the sheath fluid comprises glycerol at a concentration between about 1 to about 50% (v/v).2. The PIOAL of claim 1 , wherein the viscosity agent of the sheath fluid comprises polyvinylpyrrolidone (PVP).3. The PIOAL of claim 2 , wherein the polyvinylpyrrolidone (PVP) is at a concentration of 1% (w/v).4. The PIOAL of claim 1 , wherein the viscosity agent of the sheath fluid comprises glycerol at a concentration of 5% (v/v) and polyvinylpyrrolidone (PVP) ...

Подробнее
Номер записи: 61
04-01-2018 дата публикации

SYSTEMS, METHODS AND APPARATUS FOR ANALYSIS OF RESERVOIR FLUIDS USING SURFACE PLASMON RESONANCE

Номер: US20180003619A1
Автор: Chau Kenneth John, Molla Shahnawaz Hossain, Mostowfi Farshid, Sieben Vincent Joseph, Smythe Elizabeth Jennings Smythe Jennings
Принадлежит:

An optical sensor includes a flow cell permitting flow of a hydrocarbon-based analyte therethrough. A metallic film is disposed adjacent or within the flow cell. At least one optical element directs polychromatic light for supply to an interface of the metallic film under conditions of surface plasmon resonance (SPR) and directs polychromatic light reflected at the interface of the metallic film (which is sensitive to SPR at such interface and thus provides an SPR sensing region within the flow cell) for output to at least one spectrometer that measures spectral data of such polychromatic light. A computer processing system is configured to process the measured spectral data over time as the hydrocarbon-based analyte flows through the flow cell to determine SPR peak wavelength over time and to process the SPR peak wavelength over time to determine at least one property related to phase transition of the analyte. 1. An optical sensor comprising:a flow cell that is configured to permit flow of a hydrocarbon-based analyte through the flow cell;a metallic film disposed adjacent or within the flow cell;a light source configured to generate polychromatic light;at least one optical element configured to direct polychromatic light produced by the light source for supply to an interface of the metallic film under conditions of surface plasmon resonance and to direct polychromatic light reflected at the interface of the metallic film for output from the at least one optical element, wherein the polychromatic light reflected at the interface of the metallic film is sensitive to surface plasmon resonance at the interface of the metallic film in order to provide an SPR sensing region within the flow cell;at least one spectrometer operably coupled to the at least one optical element, wherein the at least one spectrometer is configured to measure spectral data of polychromatic light reflected at the interface of the metallic film as output by the least one optical element; anda ...

Подробнее
Номер записи: 62
04-01-2018 дата публикации

Surface plasmon resonance approach to monitor protein-ligand interactions

Номер: US20180003631A1
Автор: Frank Bosmans, Marie-France Eauclair, Pierre E. Bougis
Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, JOHNS HOPKINS UNIVERSITY

The present invention provides assays utilizing SPR to detect protein-ligand interactions as well as compositions utilized is such assays.

Подробнее
Номер записи: 63
02-01-2020 дата публикации

Apparatus to measure multiple signals from a liquid sample

Номер: US20200003663A1
Автор: Barbara R. MAURER, David Cannell, Mario YASA, Philip J. Wyatt, Steven P. Trainoff, Vincent H. Hsieh
Принадлежит: Wyatt Technology LLC

One or more homogenizing elements are employed in a flow through, multi-detector optical measurement system. The homogenizing elements correct for problems common to multi-detector flow-through systems such as peak tailing and non-uniform sample profile within the measurement cell. The homogenizing elements include coiled inlet tubing, a flow distributor near the inlet of the cell, and a flow distributor at the outlet of the cell. This homogenization of the sample mimics plug flow within the measurement cell and enables each detector to view the same sample composition in each individual corresponding viewed sample volume. This system is particularly beneficial when performing multiangle light scattering (MALS) measurements of narrow chromatographic peaks such as those produced by ultra-high pressure liquid chromatography (UHPLC).

Подробнее
Номер записи: 64
02-01-2020 дата публикации

Method and system for integrated mutliplexed modular photometry

Номер: US20200003676A1
Автор: Anne Celia PETROFSKY, Kenneth T. Kotz, Ramin Haghgooie, Robert GRANIER
Принадлежит: General Hospital Corp

Reusable network of spatially-multiplexed microfliuidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid. System and method for photometric measurements of multiple fluid samples employing such network of channels.

Подробнее
Номер записи: 65
02-01-2020 дата публикации

Surface Plasmon Resonance Fluorescence Analysis Device And Surface Plasmon Resonance Fluorescence Analysis Method

Номер: US20200003688A1
Автор: FUJII Hideyuki, NAKAMURA Yukito, Noda Tetsuya
Принадлежит:

A surface plasmon fluorescence analysis device that has a chip holder, a light source, an angle adjustment unit, a light sensor, a filter holder, an excitation light cut filter, a scattered light transmission unit, a transmission adjustment unit, and a control unit. As seen in plan view, the area occupied by the scattered light transmission unit is arranged on the excitation light cut filter or on the filter holder and is smaller than the area of a fluorescence transmission region as seen in plan view. 1. A surface plasmon resonance fluorescence analysis device to which an analysis chip including a dielectric having a metal film on one surface of the dielectric is attached and in which the metal film is irradiated with excitation light through the dielectric to excite a fluorescent material for labelling a detection target substance on the metal film , and then fluorescence emitted from the fluorescent material is detected to thereby detect the presence or amount of the detection target substance , the surface plasmon resonance fluorescence analysis device comprising:a chip holder configured to detachably hold the analysis chip;an adjustable light source configured to emit excitation light at an incident angle with respect to the metal film to irradiate the metal film with the excitation light through the dielectric at an incident angle;a light sensor configured to detect light emitted from the vicinity of a surface of the metal film, the surface facing away from the dielectric;an excitation-light cut filter configured to allow fluorescence emitted from the metal film to pass through the filter and block at least light having a certain wavelength of the excitation light; andan adjustable stage configured to tilt the excitation-light cut filter with respect to a normal line of a surface of the metal film such that plasmon scattering light emitted from the metal film is allowed to pass through;wherein the chip holder is configured to hold the analysis chip in an ...

Подробнее
Номер записи: 66
07-01-2021 дата публикации

ANALYTE SENSOR AND METHOD OF USE

Номер: US20210003499A1
Автор: Beyette, De Silva Geethanga Gayan, JR. Fred R.
Принадлежит: University of Cincinnati

A sensor for isolating, identifying, and quantifying one or more analytes in a sample is provided, the sensor having a metal substrate base and a polymer waveguide disposed on the metal substrate base, the polymer waveguide including an optical channel and a polymer disposed in the optical channel; wherein the polymer waveguide optically couples a first and a second fiber optic cable. Also provided herein are methods of using the sensor for isolating, identifying, and quantifying one or more analytes in a sample, the method including contacting the polymer waveguide with a sample, sequentially heating the sensor to a plurality of temperature thresholds, obtaining an optical output at each temperature threshold, and analyzing differences in sequentially-obtained optical outputs in order to identify and determine concentrations of individual analytes of interest in the sample.

Подробнее
Номер записи: 67
03-01-2019 дата публикации

Particle Detection Methods and Systems for Practicing Same

Номер: US20190003952A1
Автор: Hulett, III Frederic M., Shah Amish P.
Принадлежит:

Aspects of the present disclosure include methods for detecting events in a flow cytometer. Also provided are methods of detecting cells in a flow cytometer. Other aspects of the present disclosure include methods for determining a level of contamination in a flow cell. Computer-readable media and systems, e.g., for practicing the methods summarized above, are also provided. 123-. (canceled)24. A method for detecting cells in a flow cytometer , comprising:flowing a cellular sample comprising cells through a flow cell of a flow cytometer;detecting optical signals from the cells flowing through the flow cell at a first gain setting; anddetecting optical signals from the cells flowing through the flow cell at the second gain setting, wherein the second gain setting is different from the first gain setting.25. The method according to claim 24 , wherein the second gain setting is greater than the first gain setting.26. The method according to claim 25 , wherein the second gain setting is to account for the cellular sample having a high cell concentration.27. The method according to claim 24 , wherein the second gain setting is less than the first gain setting.28. The method according to claim 27 , wherein the second gain setting is to account for the cellular sample having a low cell concentration.29. The method according to claim 24 , wherein the first and second gain settings comprise a photo diodes gain setting claim 24 , a photo multiplier tubes (PMT) gain setting claim 24 , or both.30. The method according to claim 24 , wherein the cellular sample is a blood sample.31. The method according to claim 24 , comprising:analyzing the optical signals detected at the first gain setting to detect a first cell type; andanalyzing the optical signals detected at the second gain setting to detect a second cell type.32. The method according to claim 31 , wherein the first gain setting is higher than the second gain setting claim 31 , and wherein platelets are detected at the ...

Подробнее
Номер записи: 68
03-01-2019 дата публикации

METHOD FOR THERMAL CONTROL DURING SURFACE PLASMON RESONANCE ANALYSIS

Номер: US20190003957A1
Автор: Goad David Wesley, Lagrone Marcus Jeanfreau, Martin Aaron David
Принадлежит: Pall Corporation

Disclosed is an SPR sensor which includes a thermally controlled biosensor. Additionally, the current disclosure describes SPR techniques which include the step of heating the SPR sensor to temperatures greater than ambient temperature. 1. A biosensor system comprising:an optically clear substrate having a first side and a second side, said first side carrying a conductive thin metal film;a pair of conductive electrodes in contact with said conductive thin metal film;an optical prism positioned adjacent to said second side of said optically clear substrate;a block having a recessed area defining a flow channel positioned adjacent to said first side of said optically clear substrate;a flow cell defined by said first side of optically clear substrate and said block;a light source positioned to illuminate said second side of said optically clear substrate, by passing light through said optical prism;a detector apparatus positioned to receive light reflected from said second side of said optically clear substrate; and,a source of direct current electricity connected to said pair of conductive electrodes.2. The biosensor system of claim 1 , wherein said pair of electrodes contact said conductive thin metal film outside of the flow cell defined by said first side of optically clear substrate and said block.3. The biosensor system of claim 1 , further comprising a temperature sensor positioned to monitor the temperature of said flow cell defined by said first side of optically clear substrate and said block.4. The biosensor system of claim 3 , wherein said temperature sensor is positioned within said flow cell.5. The biosensor system of claim 3 , wherein said temperature sensor is secured to said thin metal film within said flow cell.6. The biosensor system of claim 3 , wherein said temperature sensor is incorporated into said block.7. The biosensor system of claim 3 , further comprising a controller configured to receive input from said temperature sensor and to adjust ...

Подробнее
Номер записи: 69
03-01-2019 дата публикации

A METHOD AND A SYSTEM FOR DETERMINING A CONCENTRATION RANGE FOR A SAMPLE BY MEANS OF A CALIBRATION CURVE

Номер: US20190005401A1
Автор: FROSTELL-KARLSSON Asa, KARNHALL Johan Hans Fredrik, RYDEN Niklas
Принадлежит:

A system and a method for determining a concentration region for a measurement of a response value by means of a calibration curve is disclosed. The calibration curve includes response values as a function of concentrations. The method includes providing a series of measured calibration data; fitting a regression model to the series of measured calibration data; calculating a standard deviation and a standard error for the measured calibration data; calculating a probability using the t-distribution with parameters including degrees of freedom and a requested confidence interval; calculating a response value interval; applying the response value interval to the calibration model; measuring a response value for a sample; and determining the concentration region by means of the response value interval and the calibration model. 1. A method for determining a concentration region for a measurement of a response value by means of a calibration curve , the calibration curve comprises response values as a function of concentrations , wherein the method comprising:providing a series of measured calibration data;fitting a regression model to the provided series of measured calibration data;calculating a standard deviation for the measured calibration data;calculating a standard error for the measured calibration data;calculating a probability using the t-distribution with parameters, the parameters comprising degrees of freedom, and a requested confidence interval;calculating a response value interval as a product of the standard error and the probability;applying the response value interval to the calibration model;measuring a response value for a sample;determining the concentration region by means of the response value interval and the calibration model.2. The method of claim 1 , wherein the step of applying the response value interval comprises:calculating a lower curve by means of subtracting the response value interval from the calibration model;calculating an upper ...

Подробнее
Номер записи: 70
20-01-2022 дата публикации

Optical Flow Cell for an Optical Measuring Device

Номер: US20220018757A1
Автор: EHRING HANNO, Ostlund Erik Nils, Svanberg Henrik
Принадлежит:

The present invention relates to an optical flow cell for a measuring device, having an input light guide with a light exit surface, an output light guide with a light entrance surface, said input light guide and output light guide being integrated with a holder to form an optical flow cell, and wherein the holder extends along a first axis and has a through hole for receiving a flow of a sample fluid, said through hole being transversal to said first axis, and the input light guide and output light guide further are arranged in said holder so that the light exit surface and the light entrance surface extend into said through hole and are arranged to be in optical alignment with each other and at a first distance from each other. The invention also relates to a measuring device having at least one optical flow cell. 2. The optical flow cell according to claim 1 , further comprising sealing rings provided to prevent leakage from the through hole.3. The optical flow cell according to claim 1 , wherein the material comprises titanium or a ceramic.4. The optical flow cell according to claim 1 , wherein the first distance is 0.2 mm or less claim 1 , preferably 0.1 mm.5. The optical flow cell according to claim 1 , wherein the input light guide is mounted in a first light guide holder and the output light guide is mounted in a second light guide holder each light guide preferably held in place in its respective holder by means of an adhesive claim 1 , and wherein the first light guide holder and second light guide holder are mounted in the holder in respective first and second mounting holes.6. The optical flow cell according to claim 5 , wherein the mounting holes are threaded and the first light guide holder and second light guide holder comprise corresponding threads claim 5 , whereby the distance is variable.7. The optical flow cell according to claim 5 , wherein the input light guide is arranged to protrude from the first light guide holder into the through hole ...

Подробнее
Номер записи: 71
08-01-2015 дата публикации

GAS SENSOR

Номер: US20150009503A1
Автор: Honda Masahito, Ishizu Koutaro, Kan Tetsuo, Matsumoto Kiyoshi, Shimoyama Isao, Takahashi Hidetoshi, TAKEI Yusuke
Принадлежит:

A gas sensor is proposed, which can detect a gas by a novel configuration while reduction in size is achieved. The gas sensor () does not need a light absorption path as in a prior art so that the size can be reduced correspondingly. Further, in the gas sensor (), a gas is absorbed in an ionic liquid (IL), and a dielectric constant of the ionic liquid (IL) that changes by absorbing the gas can be measured according to a change in light intensity that occurs by a surface plasmon resonance phenomenon in a metal layer (). Thus, the gas sensor () including the novel configuration that can detect a gas based on the change in the light intensity can be realized. 1. A gas sensor that detects a gas that is a target of detection , comprising:a prism having a metal layer in an irradiation range of an incident light incident from a light source, and changing a path of the incident light at the metal layer to emit the incident light as an exit light; anda gas absorbing liquid provided on a surface of the metal layer, and capable of absorbing the gas,wherein a dielectric constant of the gas absorbing liquid changes due to absorption of the gas in the gas absorbing liquid, and based on a change in light intensity of the exit light by a surface plasmon resonance phenomenon that occurs in the metal layer in response to the change in the dielectric constant, the gas is detected.2. The gas sensor according to claim 1 ,wherein the gas is detected based on a change amount of a dip angle that occurs by the surface plasmon resonance phenomenon when the gas absorbing liquid absorbs the gas.3. The gas sensor according to claim 1 ,wherein the gas is detected based on a change amount of reflection intensity that occurs by the surface plasmon resonance phenomenon when the gas absorbing liquid absorbs the gas.4. The gas sensor according to claim 1 ,further comprising holding means that covers the gas absorbing liquid, and causes the gas absorbing liquid to be held on the metal layer.5. The gas ...

Подробнее
Номер записи: 72
27-01-2022 дата публикации

Seal material for analyzer, and flow cell, detector, and analyzer using the same

Номер: US20220026345A1
Автор: Akiyasu OYAIZU, Katsuya Okumura, Minoru Tsuchida, Yusuke Nagai
Принадлежит: Shimadzu Corp, Tomoegawa Paper Co Ltd

Provided is a seal material having high rigidity without deformation or breakage, excellent corrosion resistance to fluid, and low solubility when used under high sealing force, and to provide a flow cell, a detector, and an analyzer in which there is no fluid leakage, contamination of the seal material components is prevented, and the replacement frequency is low. Provided are a seal material for an analyzer, including a resin and at least one layer of fiber sheet embedded in the resin, wherein the at least one layer of fiber sheet is embedded between and in substantially parallel to two seal surfaces: a first seal surface, which is one resin surface of the seal material; and a second seal surface, which is the other resin surface substantially parallel to the former one, and a flow cell, a detector, and an analyzer using the seal material.

Подробнее
Номер записи: 73
12-01-2017 дата публикации

Flow cell and liquid feed system

Номер: US20170010205A1
Автор: Emi Tamechika, Katsuyoshi Hayashi, Nobuaki Matsuura, Suzuyo Inoue, Tsutomu Horiuchi, Yuzuru Iwasaki
Принадлежит: Nippon Telegraph and Telephone Corp

A flow cell ( 2 ) includes a plate-shaped body 21 that is almost rectangular in a plan view, an introduction portion ( 22 ) that is made of a concave portion formed in the upper surface of the body ( 21 ), a channel ( 23 ) that is formed inside the body ( 21 ) and has one end connected to the lower end of the introduction portion ( 22 ), and a delivery portion ( 24 ) that is made of a concave portion formed in the body ( 21 ) and has the lower end connected to the other end of the channel ( 23 ). The introduction portion ( 22 ) is formed to cause the meniscus of a liquid introduced from an opening to apply, to the liquid, a positive pressure or a negative pressure whose absolute value is smaller than that of a negative pressure applied to the liquid introduced into the channel ( 23 ) by the meniscus of the liquid. The channel ( 23 ) is formed to cause the meniscus of the liquid introduced into the channel ( 23 ) to apply a negative pressure to the liquid. This invention provides a flow cell and a liquid feed system capable of more easily controlling feed of a trace amount of liquid.

Подробнее
Номер записи: 74
12-01-2017 дата публикации

Device for determining the concentration of at least one gas in a sample gas flow by means of infrared absorption spectroscopy

Номер: US20170010207A1
Автор: Raimund Brunner, Stephan Fetzner, Ulrich Ulmer
Принадлежит: AVL EMISSION TEST SYSTEMS GMBH

A device for determining a concentration of at least one gas in a sample gas flow by infrared absorption spectroscopy. The device includes a gas cell which includes a thermal insulation, a chamber, a heating source arranged within the thermal insulation which heats the sample gas flow to a desired temperature, and a sample gas duct having an outlet. The sample gas duct is heated by the heating source upstream of the outlet. An infrared radiation source emits a radiation which is conducted through the chamber of the gas cell. The sample gas flow is conducted into the chamber and into the radiation. A detector has the radiation exiting the chamber conducted thereto to determine an absorption spectrum.

Подробнее
Номер записи: 75
12-01-2017 дата публикации

DEVICE AND METHOD FOR DETERMINING THE CONCENTRATION OF AT LEAST ONE GAS IN A SAMPLE GAS STREAM BY MEANS OF INFRARED ABSORPTION SPECTROSCOPY

Номер: US20170010208A1
Автор: FETZNER STEPHAN
Принадлежит: AVL EMISSION TEST SYSTEMS GMBH

A device for determining a concentration of at least one gas in a sample gas flow by infrared absorption spectroscopy. The device includes an infrared radiation source which emits a radiation which is conducted through an analysis cell, a feed line, the sample gas flow which is conducted into and out of the analysis cell via the feed line, a detector which measures an absorption spectrum arising in the analysis cell, a suction jet pump which includes a propellant gas connection, and a propellant gas line which extends to the propellant gas connection of the suction jet pump. The suction jet pump is arranged downstream of the analysis cell and feeds the sample gas flow through the analysis cell via the feed line. The propellant gas line includes a regulating valve which regulates a propellant pressure in the propellant gas line. 113-. (canceled)14. A device for determining a concentration of at least one gas in a sample gas flow by infrared absorption spectroscopy , the device comprising:an infrared radiation source configured to emit a radiation which is conducted through an analysis cell;a feed line;the sample gas flow which is configured to be conducted into and out of the analysis cell via the feed line;a detector configured to measure an absorption spectrum arising in the analysis cell;a suction jet pump comprising a propellant gas connection, the suction jet pump being arranged downstream of the analysis cell and being configured to feed the sample gas flow through the analysis cell via the feed line; anda propellant gas line extending to the propellant gas connection of the suction jet pump, the propellant gas line comprising a regulating valve which is configured to regulate a propellant pressure in the propellant gas line.15. The device as recited in claim 14 , wherein the regulating valve is a proportional valve which is configured to regulate the propellant pressure in the propellant gas line as a direct function of a feed pressure in the feed line ...

Подробнее
Номер записи: 76
14-01-2016 дата публикации

COMPOUND OPTICAL FLOW CELLS AND METHOD OF MANUFACTURE AND USE

Номер: US20160011098A1
Автор: ARBOLEDA Carlos Alberto, CANO Jose M., CLARKIN James P., GRAHAM Marshall Donnie, GRAHAM William Gerry, SANCHEZ Armando J., WELLS Mark A.
Принадлежит:

An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship. 1. A method for making a transparent compound optical flow cell of the type used to characterize formed bodies passing through the flow cell , the optical flow cell having formed therein a rectilinear internal flow channel , the method comprising the steps of:providing a cylindrical monolithic preform comprising a thick-wall glass tube having an axially-extending channel therethrough and a transition temperature, the channel comprising a substantially uniform original cross-section of a desired shape;heating the preform to a predetermined temperature above the transition temperature of the glass tube;axially drawing the preform at a controlled rate, for a controlled time, and at a constant angular orientation, to achieve a desired reduced cross-sectional area of the axially-extending channel;providing an optical element, the optical element comprising a conforming surface that conforms to a segment of the drawn preform, and an exterior non-cylindrical envelope of predetermined form and orientation relative to the conforming surface;assembling the optical element ...

Подробнее
Номер записи: 77
14-01-2016 дата публикации

DISPLAY APPARATUS AND METHOD OF TESTING THE SAME

Номер: US20160011108A1
Автор: HWANG Myoungho, JEON Junhyuck, LIM DongJoon, MYOUNG Soyoung
Принадлежит:

A display apparatus includes a base substrate and a test device group. The base substrate includes a display area in which a plurality of pixels connected to a plurality of signal lines is disposed and a peripheral area disposed adjacent to the display area. The test device group includes a first pad on which a surface plasmon resonance is induced due to an electromagnetic wave incident to the first pad. The first pad is disposed in the peripheral area and completely covered by an insulating layer. 1. A display apparatus comprising:a base substrate comprising a display area in which a plurality of pixels connected to a plurality of signal lines is disposed and a peripheral area disposed adjacent to the display area; anda test device group comprising a first pad on which a surface plasmon resonance is induced due to an electromagnetic wave incident to the first pad, the first pad being disposed in the peripheral area and completely covered by an insulating layer.2. The display apparatus of claim 1 , wherein the electromagnetic wave is a polarization light in a transverse magnetic mode3. The display apparatus of claim 2 , further comprising a prism disposed on a rear surface of the base substrate to overlap with the first pad and to receive the electromagnetic wave claim 2 , wherein the first pad is disposed on a front surface of the base substrate claim 2 , which is opposite to the rear surface.4. The display apparatus of claim 3 , wherein the prism has a shape integrally formed with the base substrate.5. The display apparatus of claim 1 , wherein the first pad is connected to at least one of the plurality of signal lines.6. The display apparatus of claim 5 , wherein the first pad is disposed on a same layer as the plurality of signal lines.7. The display apparatus of claim 1 , wherein the test device group further comprises:a test circuit part connected to the first pad; anda second pad connected to the test circuit part.8. The display apparatus of claim 7 , wherein ...

Подробнее
Номер записи: 78
11-01-2018 дата публикации

APPARATUS FOR INLINE TRACE ANALYSIS OF A LIQUID

Номер: US20180011005A1
Автор: Bauhuber Michael, Hummel Helmut, Kirschner Gerhard, Lechner Alfred, Sczepan Martin, Wisspeintner Thomas
Принадлежит:

The invention relates to an apparatus for the inline trace analysis of a liquid, preferably of an aqueous process solution, comprising: a housing (); a micro-channel () through which the liquid to be examined is allowed to flow and into which light of a light source () is coupled; a detector () for light emerging from the micro-channel (); and a user interface () for monitoring and/or operating the apparatus. The micro-channel (), the detector () and/or the user interface () are arranged in the housing () and/or are integrated into the housing (), and the housing () has a connection () for feeding the liquid in the micro-channel () and a connection () for power supply of the apparatus. 115-. (canceled)16. Apparatus for inline trace analysis of a fluid , said apparatus comprising:{'b': '1', 'a housing ();'}{'b': 2', '3, 'a microchannel (), through which the fluid to be analyzed is allowed to flow and into which light of a light source () is coupled;'}{'b': 4', '2, 'a detector () for light emerging from the microchannel (); and'}{'b': '5', 'a user interface () for at least one of monitoring or operating the apparatus,'} [{'b': 2', '4', '5', '1, 'at least one of the microchannel (), the detector () or the user interface () is at least one of arranged in or integrated into the housing (), and'}, {'b': 1', '6', '2', '7, 'the housing () has a port () for feeding the fluid into the microchannel () and a terminal () for supplying power to the apparatus.'}], 'wherein17. Apparatus claim 16 , as claimed in claim 16 , wherein either:{'b': 3', '1, 'the light source () is arranged in the housing (), or'}{'b': 1', '3', '2, 'the housing () has a port for feeding the light of the light source () into the microchannel ().'}18. Apparatus claim 16 , as claimed in claim 16 , wherein either:{'b': 1', '8', '2, 'the housing () has a port () for discharging the fluid from the microchannel (), or'}{'b': 2', '1, 'a collecting container for fluid emerging from the microchannel () is arranged ...

Подробнее
Номер записи: 79
10-01-2019 дата публикации

POLYMERIC DEVICE SUITABLE FOR ULTRAVIOLET DETECTION

Номер: US20190011356A1
Автор: EHRING HANNO
Принадлежит: GE HEALTHCARE BIO-SCIENCES AB

The present invention relates to a flow cell () comprising a fluid inlet () and a fluid outlet () separated by a sample flow-through chamber () comprising at least one UV-transparent window (), wherein the at least one UV-transparent window () is made of a polymer material and has been subjected to Gamma radiation sterilisation. In one aspect, the flow cell is combustible. 1. A method for measuring UV absorption of a sample along an optical path using a Gamma radiation sterilized flow cell wherein the flow cell comprises a polypropylene material with the optical path passing at least a portion of the polypropylene material during the measurement , the method comprising:conveying the sample through the flow cell; anddetermining the UV absorption of the sample by transmitting UV light along the optional path through the polypropylene material and through the sample.2. The method of claim 1 , wherein the determining is based on the UV light transmitted through the flow cell containing the sample.3. The method of claim 2 , wherein the determining includes measuring an intensity of the transmitted UV light.4. The method of claim 3 , wherein the measuring includes detecting the transmitted UV light using a detector disposed adjacent to the flow cell.5. The method of claim 1 , wherein the flow cell is sterilized by subjecting the flow cell to a dose of at least 10 kGy of Gamma radiation.6. The method of claim 1 , wherein the flow cell includes at least one of (i) a circular wall made of polypropylene and (ii) a polypropylene window.7. The method of claim 1 , wherein a UV transmission of the polypropylene material after being sterilized does not vary by more than about 10% during an exposure to UV light for a period of about 72 hours.8. The method of claim 7 , wherein an optical power density during the exposure to UV light is about 0.6 μW/mm.9. The method of claim 1 , wherein a UV transmission of the polypropylene material after being sterilized does not vary by more than ...

Подробнее
Номер записи: 80
09-01-2020 дата публикации

OPTICAL DIFFERENTIAL INTERROGATION METHOD AND APPARATUS FOR SURFACE PLASMON RESONANCE IMAGING

Номер: US20200011790A1
Автор: CHOI Yo Han, KIM Jong Deog
Принадлежит:

According to the present invention, an optical differential interrogation method for surface plasmon resonance imaging including: letting first incident light of a first wavelength and second incident light of a second wavelength to be incident on a sample while varying an incident angle; detecting intensity of first reflection light of the first incident light and intensity of second reflection light of the second incident light; and identifying the sample by using a difference between the intensity of the first reflection light and the intensity of the second reflection light, can be provided, and thus it is possible to obtain much better angular resolution while using a detector or a camera, which has a relative low receiving sensitivity and a sensor chip where samples having various characteristics are two-dimensionally arrayed and integrated can be effectively measured. 1. An optical differential interrogation method for surface plasmon resonance imaging , comprising:letting first incident light of a first wavelength and second incident light of a second wavelength to be incident on a sample while varying an incident angle;detecting intensity of first reflection light of the first incident light and intensity of second reflection light of the second incident light; andidentifying the sample by using a difference between the intensity of the first reflection light and the intensity of the second reflection light.2. The optical differential interrogation method for surface plasmon resonance imaging of claim 1 , whereinthe identifying of the sample by using the difference between the intensity of the first reflection light and the intensity of the second reflection light comprises:detecting a first angle at which the difference between the intensity of the first reflection light and the intensity of the second reflection light becomes zero; andidentifying a sample that corresponds to the first angle.3. The optical differential interrogation method of claim 2 , ...

Подробнее
Номер записи: 81
14-01-2021 дата публикации

Wafer level sequencing flow cell fabrication

Номер: US20210013025A1
Автор: Cheng Frank Zhong, Jian Gong, Shifeng Li, Yan-You Lin
Принадлежит: MGI Tech Co Ltd

A method for forming sequencing flow cells can include providing a semiconductor wafer covered with a dielectric layer, and forming a patterned layer on the dielectric layer. The patterned layer has a differential surface that includes alternating first surface regions and second surface regions. The method can also include attaching a cover wafer to the semiconductor wafer to form a composite wafer structure including a plurality of flow cells. The composite wafer structure can then be singulated to form a plurality of dies. Each die forms a sequencing flow cell. The sequencing flow cell can include a flow channel between a portion of the patterned layer and a portion of the cover wafer, an inlet, and an outlet. Further, the method can include functionalizing the sequencing flow cell to create differential surfaces.

Подробнее
Номер записи: 82
14-01-2021 дата публикации

APPARATUS AND METHOD FOR INFRARED IMAGING

Номер: US20210014434A1
Автор: CHOI Bong Jun, HYUN Ho Jin, KANG Dae Kyeong, PARK Jong Hoo
Принадлежит:

Provided are an apparatus and a method for infrared imaging, more particularly, an apparatus and a method for infrared imaging, which receive infrared light, emitted from a target, and output the received infrared light as an image. An infrared imaging apparatus, in accordance with an exemplary embodiment, receives infrared light, emitted from a target, and outputs the received infrared light as an image. The infrared imaging apparatus includes: a reaction unit having physical properties changing in response to the received infrared light; a light source unit for generating measurement light irradiated toward the reaction unit; and an imaging unit for detecting the measurement light with the light quantity thereof changing depending on a change in the physical properties of the reaction unit and outputting the detected measurement light as an image. 1. An infrared imaging apparatus for receiving infrared light emitted from a target and outputting the received infrared light as an image , the infrared imaging apparatus being configured to detect measurement light comprising a wavelength band different from that of the infrared light and the light quantity thereof changing depending on the infrared light and to output the detected measurement light as an image.2. The infrared imaging apparatus of claim 1 , comprising:a reaction unit comprising a reactive layer with physical properties changing in response to the received infrared light;a light source unit disposed to irradiate the reaction unit with the measurement light; andan imaging unit disposed to detect the measurement light having passed through the reaction unit.3. The infrared imaging apparatus of claim 2 , wherein the measurement light comprises visible light claim 2 , and the imaging unit comprises an image sensor configured to convert the visible light into electric charges and output the electric charges as an image.4. The infrared imaging apparatus of claim 2 , wherein the reaction unit further comprises ...

Подробнее
Номер записи: 83
03-02-2022 дата публикации

LARGE DYNAMIC RANGE KINETIC MONITOR

Номер: US20220034798A1
Автор: Kraus Paul R., Ryther Robert James
Принадлежит:

Disclosed herein are systems and methods for measuring one or more target analyte concentrations, particularly peroxyacid compounds, in a process solution, for example, in industrial and commercial water. These systems and methods include automated methods to measure the target analyte concentration in the process solution. The methods have the advantage of providing a large dynamic range for measurement and can be used in a wider range of process solutions. 1. An automated sensor comprising:a sample treatment system comprising a sample pump and a sample filter, wherein the sample pump is for pumping a sample into a reaction manifold, wherein the sample comprises an analyte;a first reagent pump for pumping a first reagent into the reaction manifold;the reaction manifold for mixing the sample with the first reagent, the reaction manifold being in fluid communication with the sample treatment system and the first reagent pump;a measurement chamber in fluid communication with the reaction manifold;a first detector in fluid communication with the measurement chamber for detecting a property of the analyte in the measurement chamber;a waste line for removing waste from the measurement chamber and having a fluid communication to the measurement chamber;a waste pump in fluid communication with the waste line for removing the sample and the first reagent from the sensor;a rinse line in fluid communication with the measurement chamber; anda controller communicatively coupled to the sample pump, the first reagent pump, and the first detector, wherein the controller controls the sample pump to set the flow rate of the sample, controls the first reagent pump to set the flow rate of the first reagent, and receives data from the detector to detect the property of the analyte.2. The automated sensor of claim 1 , wherein the sample is a continuously flowing and refreshed sample.3. The automated sensor of claim 2 , further comprising a rinse pump for pumping a rinse solution and ...

Подробнее
Номер записи: 84
03-02-2022 дата публикации

FLUID HANDLING DEVICE, FLUID HANDLING SYSTEM AND LIQUID DETECTION METHOD

Номер: US20220034806A1
Автор: SUNAGA Nobuya
Принадлежит:

A fluid handling device includes a channel including a roughened surface that causes irregular reflection of light. A fluid handling system includes the fluid handling device, an irradiation part for irradiating the roughened surface of the channel with light, and a light detection part for detecting light reflected by the roughened surface or light transmitted through the roughened surface after irradiation from the light irradiation part. 1. A fluid handling device comprising:a channel including a roughened surface configured to cause irregular reflection of light.2. The fluid handling device according to claim 1 , wherein the roughened surface has a surface roughness Ra of 0.001 mm to 1 mm3. The fluid handling device according to claim 1 ,wherein the channel includes a detection target region configured to be irradiated with light for detection of transmitted light or reflection light, the detection target region including the roughened surface; andwherein the fluid handling device further includes a light blocking part disposed around the detection target region.4. The fluid handling device according to claim 3 , wherein in plan view of the fluid handling device claim 3 , the light blocking part is disposed at a position that does not overlap the channel5. The fluid handling device according to claim 4 , wherein in plan view of the fluid handling device claim 4 , the light blocking part is disposed also at a position that overlaps a region other than the detection target region of the channel6. The fluid handling device according to claim 1 , further comprising:a liquid storage part disposed in the channel; anda detection target region disposed adjacent to the liquid storage part at the channel and configured to be irradiated with light for detection of transmitted light or reflection light, the detection target region including the roughened surface.7. A fluid handling system comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the fluid handling ...

Подробнее
Номер записи: 85
03-02-2022 дата публикации

Integrated illumination-detection flow cell for liquid chromatography

Номер: US20220034855A1
Автор: Doug CHILDERS, Garth Eliason, Jay PASQUANTONIO, John Christopher Freitag, Patrick KAIN
Принадлежит: Phoseon Technology Inc

A liquid chromatography flow cell including an integrated light source and an integrated detection chamber. The integrated light source includes a plurality of light emitting diodes (LEDs), wherein each LED emits light of a specific wavelength. The light emitted from the integrated light source is directed to pass through a sample in a flow chamber of the flow cell without any optical conditioning, and the light not absorbed by the sample flows out of the flow chamber directly into the integrated detection chamber, where an intensity of the unabsorbed light is measured by detectors coupled to the integrated chamber.

Подробнее
Номер записи: 86
19-01-2017 дата публикации

Inline buried metal void detection by surface plasmon resonance (spr)

Номер: US20170016822A1
Автор: Sabarinath JAYASEELAN, Suraj Kumar PATIL
Принадлежит: Globalfoundries Inc

A method and apparatus are provided for using SPR to detect buried voids in a semiconductor wafer inline post metal deposition. Embodiments include forming a first, a second, and a third metal structure in a first, a second, and a third adjacent die of a wafer; performing a SPR on the first, second, and third metal structures inline; detecting a first, a second, and a third SPR wavelength corresponding to the first, second, and third metal structures, respectively; comparing a difference between the first SPR wavelength and the second SPR wavelength and a difference between the third SPR wavelength and the first SPR wavelength against a threshold value; and determining a presence or an absence of a buried void in the first metal structure based on the comparison.

Подробнее
Номер записи: 87
21-01-2016 дата публикации

Infrared absorption spectroscopy

Номер: US20160018263A1
Автор: Hatice Altug, Ronen Adato
Принадлежит: Hatice Altug, Ronen Adato

The present invention relates to an infrared absorption spectroscopy apparatus including an infrared transparent substrate comprising a first and second surface, an array of plasmonic nano-antennas arranged on the first surface of the infrared transparent substrate, a flow cell for holding a liquid to allow spectroscopy measurements in a liquid environment, the array of plasmonic nano-antennas being located inside the flow cell, an optical source providing an incident light probe signal incident on at least a part of the array of plasmonic nano-antennas via the second surface of the infrared transparent substrate, and an optical element to collect reflected light signal reflected by said part of the array of plasmonic nano-antennas.

Подробнее
Номер записи: 88
21-01-2016 дата публикации

SYSTEMS AND METHODS FOR REFRACTIVE INDEX DETECTION

Номер: US20160018326A1
Автор: BALA Senthil, BASILE Mark, FREDETTE Colin, JEANOTTE Anthony C.
Принадлежит:

The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.

Подробнее
Номер записи: 89
21-01-2016 дата публикации

OPTICAL DETECTION SYSTEM WITH TILTED SENSOR

Номер: US20160018329A1
Автор: WALTERS Robert Joseph
Принадлежит: Integrated Plasmonics Corporation

A detection system includes a planar plasmonic element for analyzing an analyte, the plasmonic element having dielectric and metallic regions, the plasmonic element emitting light that carries detected information; and a planar two-dimensional image sensor positioned in non-parallel angled relationship with respect to a plane of the plasmonic element to enhance a spatial image resolution for the light that carries detected information with respect to at least a portion of the light.

Подробнее
Номер записи: 90
18-01-2018 дата публикации

BINDING ASSAY SIGNAL ANALYSIS

Номер: US20180017483A1
Автор: Da Fonseca João Manuel de Oliveira Garcia
Принадлежит:

Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample. 1. A method for determining a sample concentration of target entities in a sample , the method comprising:obtaining assay data comprising data points of respective local measurements indicative of a local concentration of the target entities at each of a plurality of assay areas of an assay assembly, wherein the assay areas are connected in series such that a sample flowing through the assay assembly flows past each assay area in sequence, and wherein each assay area comprises a plurality of probe entities immobilized at a surface of the assay area, the probe entities being arranged to bind to the target entities in the sample, such that the concentration of the target entities is depleted as the sample flows from one of the assay areas to the next;modeling the assay data with a parameterized function of the local measurements against a quantity indicative of the position of the respective assay areas in the sequence, wherein one or more of the parameters are dependent on the sample concentration; anddetermining a value indicative of the sample concentration based on at least one of the one or more parameters.2. A method according to claim 1 , wherein the parameterized function is derived from assay data sets obtained for a range of sample concentrations.3. A method according to claim 1 , wherein one of the one or more parameters is indicative of an offset amount which offsets the quantity indicative of the position of the assay area in the sequence such that the parameterized function is a function of the local measurements against the quantity indicative of the position of the assay area in the sequence claim 1 , offset by the offset amount.4. A method according to claim 3 , wherein the offset amount is determined by minimizing a difference between the respective local ...

Подробнее
Номер записи: 91
16-01-2020 дата публикации

OPTICAL SENSOR EMPLOYING A REFRACTIVE INDEX ENGINEERED METAL OXIDE MATERIAL

Номер: US20200017409A1
Автор: BURIC MICHAEL PAUL, CHEN PENG, OHODNICKI PAUL R., POOLE JACOB LORENZI
Принадлежит:

An optical sensor device includes an optical waveguide portion having a core, the core having a first refractive index, and a functional material layer coupled to the optical fiber portion, the functional material layer being made of a metal oxide material, the functional material layer being structured to have a second refractive index, the second refractive index being less than the first refractive index. The functional material layer may be a nanostructure material comprising the metal oxide material with a plurality of holes or voids formed therein such that the functional material layer is caused to have the second refractive index. 1. An optical sensor device structured for spatially distributed sensing of an analyte in an environment at multiple locations along the optical sensor device , comprising:an optical waveguide portion having a core, the core having a first refractive index; anda functional material layer coupled to the optical waveguide portion, the functional material layer being comprised of a material that in a bulk, fully dense form has a natural, non-engineered refractive index that is greater than the first refractive index, the functional material layer being structured to have an engineered second refractive index that is lower than the first refractive index, wherein the functional material layer is an engineered nanostructure material with a plurality of voids formed therein, wherein throughout the functional material layer a porosity of the functional material layer is uniform and a size and a shape of the voids is uniform such that the functional material layer is caused to have the engineered second refractive index and such that light scattering in the optical sensor device is minimized, wherein the functional material layer is a material wherein at least one of the engineered second refractive index of the functional material layer or the optical absorption of the functional material layer will change in response to a parameter ...

Подробнее
Номер записи: 92
17-01-2019 дата публикации

Dual-image based bioimaging devices and techniques

Номер: US20190017905A1
Автор: TsungFeng WU, Yu-Chen Chen
Принадлежит: Vor Inc

Disclosed are methods, systems, and devices for detecting biological analytes in a sample. The disclosed technology can be used to obtain readings of analyte concentration in a sample by imaging scattered light from an angled narrow beam illuminator. A fluid sample containing one or more biological, organic, and inorganic analytes including proteins, viruses, bacteria, phages, toxins, peptides, DNA, RNA, hormones, chemicals, drugs, and isotopes can be transferred to a microfluidic device having one or more channels with dimensions to generate capillary action for sample transport. The geometry of the microfluidic device may include a reservoir and sensing area, wherein an immunometric reaction can take place for the narrow beam scanning. The test particle may be coated with a specific binding member that is used to bind the binding pair member on an analyte in a sample. Test particles form the binding and the particle/analyte conjugate may be scanned.

Подробнее
Номер записи: 93
17-01-2019 дата публикации

DIRECT AFFINITY MEASUREMENT OF HUMAN IGG1 BINDING MULTIMERIC ANTIGENS

Номер: US20190018009A1
Автор: ENDESFELDER Manuel, GASSNER CHRISTIAN, MOELLEKEN JOERG, Molhoj Michael
Принадлежит: Hoffmann-La Roche Inc.

Herein is reported a method for determining the binding affinity of the binding sites of a bivalent full length antibody of the human IgG1 subclass to a homo-multimeric antigen comprising the steps of i) incubating a mixture comprising the antibody and a polypeptide that is derived from lysine-gingipain of porphyromonas gingivalis at a pH of from pH 7.5 to pH 8.5, in the presence of a reducing agent, at a temperature of from 30° C. to 42° C., for time of from 10 min. to 240 min. to cleave the antibody into Fabs and Fc-region, and ii) determining the binding affinity of the Fabs of the antibody for its antigen using a surface plasmon resonance method by directly applying the incubated reaction mixture obtained in the previous step in the surface plasmon resonance method and therewith determining the binding affinity of the binding sites of the bivalent full length antibody of the human IgG1 subclass. 1. A method for determining the binding affinity of the binding sites of a bivalent full length antibody of the human IgG1 subclass to a homo-multimeric antigen comprising the following steps:{'i': 'porphyromonas gingivalis', 'incubating a mixture comprising the antibody and lysine-gingipain of or an enzymatically active fragment thereof at a pH of 7.5 to 8.5, in the presence of a reducing agent, at a temperature of 30° C. to 42° C., for a time of 10 min. to 240 min. to cleave the antibody into Fabs and Fc-region, and'}determining the binding affinity of the Fabs of the antibody for its antigen using surface plasmon resonance by directly applying the incubated reaction mixture obtained in the previous step in the surface plasmon resonance method andthereby determining the binding affinity of the binding sites of the bivalent full length antibody of the human IgG1 subclass.2porphyromonas gingivalis. The method according to claim 1 , wherein the lysine-gingipain of has the amino acid sequence of SEQ ID NO: 02 or SEQ ID NO: 03 or SEQ ID NO: 04 or is a functional variant ...

Подробнее
Номер записи: 94
16-01-2020 дата публикации

ELLIPSOMETRY SYSTEM FOR MEASURING MOLECULAR BINDING, ADSORPTION AND DESORPTION

Номер: US20200018690A1
Автор: Ow Dave Siak-wei, Sutarlie Laura, Tandiono Tandiono, Yakovlev Nikolai
Принадлежит:

According to one aspect of the invention, there is provided an ellipsometry system for measuring any one or more of molecular binding, adsorption and desorption on a substrate, the system comprising: a) a cuvette comprising i) a body within which a cavity is formed and an opening on the body, wherein the cavity extends into the opening through which the substrate is immersed; ii) a window formed on each of two oppositely located walls of the body, wherein the windows are aligned to allow light to enter through one of the two windows to reflect off the portion of the substrate immersed in the cavity and exit through the other of the two windows; iii) a channel arrangement enclosed within the body of the cuvette and comprising two non-contiguous portions, wherein one of the two non-contiguous portions guides fluid into the cavity and the other non-contiguous portion guides fluid out of the cavity; b) a polarized light source disposed to provide the light that enters into one of the two windows on the body of the cuvette; and c) a detection stage disposed to receive the light that exits through the other of the two windows on the body of the cuvette, wherein the detection stage is configured to measure polarization rotation of the received light, the polarization rotation caused by any one or more of molecular binding, adsorption and desorption occurring on the substrate surface. The detection stage preferably contains a polarisation modulator, which is configured to measure polarization rotation of the received light. 1. An ellipsometry system for measuring any one or more of molecular binding , adsorption and desorption on a substrate , the system comprising: (i) a body within which a cavity is formed and an opening on the body, wherein the cavity extends into the opening through which the substrate is immersed;', '(ii) a window formed on each of two oppositely located walls of the body, wherein the windows are aligned to allow light to enter through one of the two ...

Подробнее
Номер записи: 95
16-01-2020 дата публикации

System and method for impurity detection in beverage grade gases

Номер: US20200018694A1
Автор: Adam R. Klempner, Anthony S. Bonanno, Charles Mark Phillips, Martin L. Spartz, Peter Paul Behnke
Принадлежит: Mls Acq Inc

A system and method for determining impurities in a beverage grade gas such as CO 2 or N 2 relies on a coupling of FTIR analysis and UV fluorescence detection. Conversion of reduced sulphur present in some impurities to SO 2 can be conducted using a furnace. In some cases, CO 2 % also is determined.

Подробнее
Номер записи: 96
17-04-2014 дата публикации

Flow Cell Assembly for Liquid Sample Analyzer

Номер: US20140104605A1
Автор: David M. Aikens, Gregory Hanlon, Joseph L. DiCesare, Richard Edwards, Timothy Neal
Принадлежит: PerkinElmer Health Sciences Inc

A flow cell assembly for use in a liquid sample analyzer including a radiation source, a sensing device and a liquid sample source to supply a liquid sample includes an entrance joint member, a liquid core waveguide, a liquid sample feed tube, and an input optical fiber. The entrance joint member includes a waveguide receiving bore and a feed tube receiving bore. The liquid core waveguide is mounted in the waveguide receiving bore and defines a waveguide bore. The liquid sample feed tube is mounted in the feed tube receiving bore such that the liquid sample feed tube is in fluid communication with the waveguide bore to fluidly connect the liquid sample source to the waveguide bore. The input optical fiber is mounted in the entrance joint member to transmit radiation from the radiation source to the waveguide bore, which radiation is transmitted through the waveguide bore and the liquid sample therein to the sensing device.

Подробнее
Номер записи: 97
17-04-2014 дата публикации

FLOW CELL MODULES AND LIQUID SAMPLE ANALYZERS AND METHODS INCLUDING SAME

Номер: US20140104617A1
Автор: Edwards Richard, Hanlon Gregory, Neal Timothy
Принадлежит:

A flow cell module for use in a liquid sample analyzer includes a module housing, a liquid core waveguide mounted in the module housing to receive a flow of a liquid sample from a liquid sample source, an input optical fiber disposed in the module housing to transmit radiation from a radiation source to the liquid core waveguide, an input termination located on an input end of the input optical fiber, a first kinematic connection mechanism operative to bias the input termination in a first direction along a first axis while permitting displacement of the input termination in a first opposing direction along the first axis, and a second kinematic connection mechanism operative to bias the input termination in a second direction along a second axis while permitting displacement of the input termination in a second opposing direction along the second axis. The second axis is transverse to the first axis. 1. A flow cell module for use in a liquid sample analyzer , the liquid sample analyzer including a radiation source , a sensing device and a liquid sample source , the flow cell module comprising:a module housing;a liquid core waveguide mounted in the module housing and configured to receive a flow of a liquid sample from the liquid sample source;an input optical fiber disposed in the module housing and configured to transmit radiation from the radiation source to the liquid core waveguide;an input termination on an input end of the input optical fiber;a first kinematic connection mechanism operative to bias the input termination in a first direction along a first axis while permitting displacement of the input termination in a first opposing direction along the first axis; anda second kinematic connection mechanism operative to bias the input termination in a second direction along a second axis while permitting displacement of the input termination in a second opposing direction along the second axis, wherein the second axis is transverse to the first axis; the first ...

Подробнее
Номер записи: 98
26-01-2017 дата публикации

SINGLE ELEMENT HYDROGEN SENSING MATERIAL BASED ON HAFNIUM

Номер: US20170023475A1
Автор: Boelsma Christiaan, Dam Bernard
Принадлежит:

A single element thin-film device, a method for producing a thin-film device, a single element for detecting hydrogen absorption, a hydrogen sensor, and an apparatus for detecting hydrogen and to an electro-magnetic transformer comprising such sensor. A thin-film device comprises a substrate, an active sensing layer whose optical properties change depending on hydrogen content, and a protective layer on the active sensing layer. 1. An optical measuring device allowing controlled and reliable optical measurement of large range molecular hydrogen pressure comprising:(a) a substrate;(b) at least one optical thin film sensing layer of 5-1000 nm thickness on the substrate, the at least one optical sensing layer consisting of a single transition metal, the metal being selected from the group consisting of Hf, Ta, Ti, Zr, V and Nb, the optical sensing layer having optical properties that may change continuously as a function of hydrogen content;(c) a protective layer with a thickness in the range of 0.02-200 pm provided on the optical sensing layer either directly or through an adhesive layer;(d) a catalyst layer with a thickness in the range of 1.5-500 nm between the optical sensing layer and the protective layer; and(e) an optical sensor for measuring optical properties in a wavelength range of 200-3000 nm of the optical sensing layer.2. The thin-film device according to claim 1 , wherein the optical sensing layer has a thickness in the range of 1.5-500 nm claim 1 , and wherein the protective layer has a thickness in the range of 0.02-200 μm.3. The thin-film device according to claim 1 , wherein the protective layer and the catalyst layer are combined.4. The thin-film device according to claim 1 , wherein the transition metal is capable of comprising hydrogen in an amount of [transition metal (TM)]:[H] of [1 claim 1 ,2].5. The thin-film device according to claim 1 , wherein the optical sensing layer comprises at least two layers claim 1 , each layer consisting of a ...

Подробнее
Номер записи: 99
25-01-2018 дата публикации

MOTION MODULATION FLUIDIC ANALYZER SYSTEM

Номер: US20180024041A1
Автор: Guasto Jeffrey, Kuehl Donald, Marshall Charles McAllister, Wagner Matthias
Принадлежит:

A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle. 1. A method of measuring a property of a fluid with a fluid analyzer , comprising:creating adjacent spatial regions of a first fluid and a second fluid in a fluid channel of a fluidic flow cell;positioning an interrogation region across a fluid boundary region separating the first fluid and second fluid in the fluid channel such that the interrogation region sequentially contains predominately the first fluid in a first time interval and primarily the second fluid in a second time interval;illuminating the interrogation region with an optical source signal to create an interrogation signal from the interaction of the optical source signal and the first fluid and second fluid within the interrogation region;measuring the interrogation signal with a transducer to produce a measured interrogation signal; andprocessing the measured interrogation signal to determine a first property of the first fluid or a second property of the second fluid.2. The method of claim 1 , further comprising varying a relative pressure of the first fluid and second fluid to move the position of the fluid boundary region in a direction substantively orthogonal to a flow ...

Подробнее
Номер записи: 100