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27-01-2005 дата публикации

СТЕНД ДЛЯ ИЗГОТОВЛЕНИЯ МИКРОСФЕР

Номер: RU0000043476U1
Автор: Дрожжин В.С., Кардаш В.К., Куваев М.Д., Пикулин И.В.
Принадлежит: Российская Федерация в лице Федерального агентства по атомной энергии, Федеральное государственное унитарное предприятие "Российский федеральный ядерный центр - Всероссийский научно-исследовательский институт экспериментальной физики"-ФГУП "РФЯЦ-ВНИИЭФ"

1. Стенд для изготовления микросфер, включающий вертикальную трубчатую высокотемпературную печь с вакуумными затворами на входе и выходе, устройство загрузки шихты, сборник микросфер, холодильник, установленный между печью и сборником микросфер, источник газа, вакуумный насос и датчики давления, установленные в магистралях, соединяющих печь с источником газа и вакуумным насосом, отличающийся тем, что стенд дополнительно содержит элементы для создания в печи непрерывного газового потока и регулирования его скорости при заданном составе и давлении газовой среды, при этом один элемент установлен в магистрали, соединяющей источник газа с печью, а второй - между сборником микросфер и вакуумным насосом. 2. Стенд по п.1, отличающийся тем, что сборник микросфер с вакуумным насосом соединен двумя параллельными магистралями с разной пропускной способностью, в одной из которых установлен второй элемент для регулирования скорости газового потока. 3. Стенд по п.1 или 2, отличающийся тем, что элемент регулирования скорости газового потока выполнен в виде ротаметра и вентиля. 4. Стенд по п.1, отличающийся тем, что перед вакуумным насосом установлен защитный электромагнитный клапан. 5. Стенд по п.1, отличающийся тем, что между устройством загрузки и вакуумным затвором установлен предохранительный клапан. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 43 476 (13) U1 (51) МПК B01J 13/02 (2000.01) C03B 19/10 (2000.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21), (22) Заявка: 2004127348/22 , 13.09.2004 (24) Дата начала отсчета срока действия патента: 13.09.2004 (45) Опубликовано: 27.01.2005 4 3 4 7 6 R U Формула полезной модели 1. Стенд для изготовления микросфер, включающий вертикальную трубчатую высокотемпературную печь с вакуумными затворами на входе и выходе, устройство загрузки шихты, сборник микросфер, холодильник, установленный между печью и сборником микросфер, источник газа, вакуумный насос и датчики давления ...

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Номер записи: 1
20-11-2013 дата публикации

УСТРОЙСТВО ДЛЯ СИНТЕЗА КОЛЛОИДНЫХ ПОЛУПРОВОДНИКОВЫХ НАНОКРИСТАЛЛОВ НИЗКОТЕМПЕРАТУРНЫМ ЗОЛЬ-ГЕЛЬ МЕТОДОМ

Номер: RU0000134445U1
Автор: Овчинников Олег Владимирович, Перепелица Алексей Сергеевич, Смирнов Михаил Сергеевич, Шапиро Борис Исаакович, Шатских Тамара Сергеевна
Принадлежит: Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный университет" (ФГБОУ ВПО "ВГУ")

Устройство для синтеза коллоидных полупроводниковых нанокристаллов низкотемпературным золь-гель методом, включающее термостатируемый реактор, жидкостный термостат, насос, мешалку, электродвигатель и блок питания электродвигателя, отличающееся тем, что содержит pH-метр, частотометр, термостатируемый реактор емкостного типа, который представляет из себя цилиндрический сосуд из коррозионно-стойкой стали с двойными стенками и штуцерами в верхней части для подключения жидкостного термостата, причем используется перистальтический насос, а крышка реактора имеет окно визуального контроля и технологические отверстия для введения реагентов, электродов pH-метра, мешалки, термометра. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 134 445 U1 (51) МПК B01J 13/00 (2006.01) B82B 3/00 (2006.01) B82Y 40/00 (2011.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ 2013127444/05, 17.06.2013 (24) Дата начала отсчета срока действия патента: 17.06.2013 (45) Опубликовано: 20.11.2013 Бюл. № 32 1 3 4 4 4 5 R U Формула полезной модели Устройство для синтеза коллоидных полупроводниковых нанокристаллов низкотемпературным золь-гель методом, включающее термостатируемый реактор, жидкостный термостат, насос, мешалку, электродвигатель и блок питания электродвигателя, отличающееся тем, что содержит pH-метр, частотометр, термостатируемый реактор емкостного типа, который представляет из себя цилиндрический сосуд из коррозионно-стойкой стали с двойными стенками и штуцерами в верхней части для подключения жидкостного термостата, причем используется перистальтический насос, а крышка реактора имеет окно визуального контроля и технологические отверстия для введения реагентов, электродов pH-метра, мешалки, термометра. Стр.: 1 U 1 U 1 (54) УСТРОЙСТВО ДЛЯ СИНТЕЗА КОЛЛОИДНЫХ ПОЛУПРОВОДНИКОВЫХ НАНОКРИСТАЛЛОВ НИЗКОТЕМПЕРАТУРНЫМ ЗОЛЬ-ГЕЛЬ МЕТОДОМ 1 3 4 4 4 5 Адрес для переписки: 394006, г. Воронеж, Университетская пл., 1, ФГБОУ ВПО "ВГУ", ЦКТ (73) ...

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27-10-2015 дата публикации

ПРОГРАММИРУЕМОЕ УСТРОЙСТВО ДЛЯ ЭЛЕКТРОХИМИЧЕСКОЙ ОБРАБОТКИ РАСТВОРОВ

Номер: RU0000156135U1
Автор: Борисанова Яна Андреевна, Купцов Никита Дмитриевич, Наумова Галина Алексеевна, Саманов Виктор Васильевич, Синельникова Юлия Юрьевна, Фомичев Валерий Тарасович
Принадлежит: Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Волгоградский государственный университет"

Программируемое устройство для электрохимической обработки растворов, содержащее задающий генератор с устройством управления, электролизер, в котором размещены электроды, выполненные из растворимого металла, отличающееся тем, что введен полупроводниковый усилитель мощности, который обеспечивает комплексную автоматизацию процесса изменения свойств электролизера, а именно, поддержание реверсивного значения тока за счет обратной связи с задающим генератором с устройством управления, причем выход задающего генератора с устройством управления взаимосвязан со входом полупроводникового усилителя мощности, который, в свою очередь, связан с двумя электродами, выполненными из растворимого металла, и помещенными в раствор, находящийся в электролизере. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 156 135 U1 (51) МПК C02F 1/463 (2006.01) B01J 13/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ 2015101661/05, 20.01.2015 (24) Дата начала отсчета срока действия патента: 20.01.2015 (45) Опубликовано: 27.10.2015 Бюл. № 30 (73) Патентообладатель(и): Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Волгоградский государственный университет" (RU) 1 5 6 1 3 5 R U Формула полезной модели Программируемое устройство для электрохимической обработки растворов, содержащее задающий генератор с устройством управления, электролизер, в котором размещены электроды, выполненные из растворимого металла, отличающееся тем, что введен полупроводниковый усилитель мощности, который обеспечивает комплексную автоматизацию процесса изменения свойств электролизера, а именно, поддержание реверсивного значения тока за счет обратной связи с задающим генератором с устройством управления, причем выход задающего генератора с устройством управления взаимосвязан со входом полупроводникового усилителя мощности, который, в свою очередь, связан с двумя электродами, выполненными из растворимого ...

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Номер записи: 3
18-09-2017 дата публикации

Устройство для синтеза наночастиц методом импульсной лазерной абляции в потоке жидкости

Номер: RU0000173887U1
Автор: Савкин Александр Николаевич, Сидоровнина Татьяна Юрьевна
Принадлежит: Сидоровнина Татьяна Юрьевна

Полезная модель относится к области получения наночастиц методом импульсной лазерной абляции в жидкости, в частности, и может быть использована для получения наночастиц различных материалов, как металлических, так и неметаллических. Устройство содержит проточную кювету для размещения мишени, имеющую входное окно для лазерного излучения, резервуар с исходным раствором и резервуар с раствором наночастиц, перистальтический насос и датчик контроля концентрации частиц. Также оно снабжено микрорасходомером, двумя цанговыми штуцерами, демпфером пульсаций скорости потока, краном прямого потока, краном возвратного потока и узлом для крепления мишени, а в боковых стенках корпуса кюветы выполнены продольные каналы для распределения потока. В дне корпуса - центральный канал, в котором установлен узел для крепления мишени, выполненный в виде крышки, закрепленной на дне центрального канала. При этом один канал для распределения потока через штуцер, микрорасходомер и перистальтический насос гидравлически связан с резервуаром с исходным раствором. Второй канал для распределения потока через второй штуцер, датчик контроля концентрации частиц и кран прямого потока гидравлически связан с резервуаром с раствором наночастиц, а резервуар с раствором наночастиц и резервуар с исходным раствором гидравлически связаны между собой через кран возвратного потока. Устройство позволяет получить ламинарный поток в рабочем объеме кюветы при двух способах протока жидкости в системе - прямом и возвратном. 1 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 173 887 U1 (51) МПК B01J 13/00 (2006.01) B82B 3/00 (2006.01) B82Y 40/00 (2011.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21)(22) Заявка: 2016119032, 17.05.2016 (24) Дата начала отсчета срока действия патента: 17.05.2016 (72) Автор(ы): Савкин Александр Николаевич (RU), Сидоровнина Татьяна Юрьевна (RU) (73) Патентообладатель(и): Сидоровнина Татьяна Юрьевна (RU) Дата регистрации: (56) Список документов, ...

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Номер записи: 4
29-04-2021 дата публикации

УСТАНОВКА ДЛЯ ПОЛУЧЕНИЯ ПОЛИМЕРНЫХ МИКРОКАПСУЛ СФЕРИЧЕСКОЙ ФОРМЫ

Номер: RU0000203963U1
Автор: Акунец Александр Алексеевич, Борисенко Наталия Глебовна, Пастухов Александр Валерьянович
Принадлежит: Федеральное государственное бюджетное учреждение науки Физический институт им. П.Н. Лебедева Российской академии наук (ФИАН)

Полезная модель относится к установке для получения полимерных микрокапсул сферической формы, используемых в качестве контейнеров термоядерного топлива. Установка для получения полимерных микрокапсул 17 сферической формы содержит: капельницу 1, выполненную из помещенных одна в другую внутренней, средней и внешней коаксиальных трубок, средство 3 подачи воды, соединенное со входом внутренней коаксиальной трубки капельницы 1, средство 4 подачи раствора полимера, соединенное со входом средней коаксиальной трубки капельницы 1, средство 5 подачи раствора поверхностно-активного вещества (ПАВ), соединенное со входом внешней коаксиальной трубки капельницы 1, реактор 2, в который сверху введены выходы всех трех коаксиальных трубок капельницы 1, спиральную лопасть мешалки 6, помещенную в реактор 2 и предназначенную для перемешивания его содержимого. Вал двигателя 7 соединен со спиральной лопастью 6 через еще одно горло реактора 2. В реакторе 2 поддерживается уровень 10 раствора ПАВ. Реактор 2 может быть помещен своей нижней частью в емкость 8 с теплоносителем, например водой, где под емкостью 8 установлен регулируемый источник 9 нагрева. Технический результат - повышение количественного выхода капсул-оболочек строго сферической формы. 6 з.п. ф-лы, 5 ил., 4 пр. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 203 963 U1 (51) МПК B01J 13/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК B01J 13/00 (2021.02) (21)(22) Заявка: 2020131403, 24.09.2020 (24) Дата начала отсчета срока действия патента: Дата регистрации: Приоритет(ы): (22) Дата подачи заявки: 24.09.2020 (45) Опубликовано: 29.04.2021 Бюл. № 13 2 0 3 9 6 3 R U (56) Список документов, цитированных в отчете о поиске: US 20170133110 A1, 11.05.2017. WO 2016002365 A1, 07.01.2016. RU 2109521 C1, 27.04.1998. JP 5728560 B2, 03.06.2015. TAKAGI MASARU ET AL, Development of High Quality Poly(α-Methylstyrene) Mandrels for NIF. Fusion Science and Technology, 2002, 41(3P1), pp. ...

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Номер записи: 5
08-09-2021 дата публикации

ЭЛЕКТРОЛИТИЧЕСКИЙ ГЕНЕРАТОР КОЛЛОИДНОГО НАНОСЕРЕБРА, ИНТЕГРИРОВАННЫЙ В ИНЪЕКЦИОННЫЙ ШПРИЦ

Номер: RU0000206365U1
Автор: Василевич Фёдор Иванович, Гаусс Константин Робертович, Ипполитова Татьяна Владимировна
Принадлежит: Федеральное государственное бюджетное образовательное учреждение высшего образования "Московская государственная академия ветеринарной медицины и биотехнологии - МВА имени К.И. Скрябина" (ФГБОУ ВО МГАВМиБ - МВА имени К.И. Скрябина)

Предметом описываемой полезной модели является электроприбор, предназначенный для получения, хранения и точного дозирования препарата - гидроколлоидного наносеребра. Данная разработка относится к области медицинской электротехники и приборостроения и применима в областях: фармакологии, гуманной и ветеринарной медицины, зоотехники, лабораторной техники и оборудования, растениеводства, а также в сфере быта. Осуществление полезной модели достигается путем монтажа основных конструктивных элементов электролитического генератора внутри медицинского инъекционного шприца. При этом пара серебряных (999,9) электродов (1) закрепляется на поверхности поршня шприца (2) таким образом, чтобы электрическая контактная часть электрода проходила сквозь поршень и была герметично в него вмонтирована (3). При этом максимально большая часть рабочей поверхности серебряных электродов должна быть размещена внутри цилиндра шприца (7), а место электрического соединения электрода с электрическим разъемом или электрокабелем - в толще массы герметика (3) с внешней стороны поршня. Штекерный электрический разъем (4) также крепится на поверхности штока шприца (5) и служит как для подключения генератора к внешнему источнику питания и электронных блоков, так и для мануального переключения с целью изменения электрической полярности. Такой электролитический генератор способен работать с любым низковольтным источником электропитания, работающим в миллиамперном диапазоне, не зависимо от характера тока. Настоящей полезной моделью также предусмотрено создание адаптера (6), обеспечивающего подключение штекерного разъема генератора к внешним USB-источникам тока, либо электронно-измерительному оборудованию. Для производства коллоидного наносеребра внутреннюю полость шприца заполняют дистиллированной водой, затем удаляют излишний воздух и подключают генератор к соответствующему источнику электропитания. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 206 365 U1 (51) МПК C02F 1/46 (2006.01) B01J 13/00 (2006.01) B82Y 40/ ...

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Номер записи: 6
12-01-2012 дата публикации

Encapsulated cure systems

Номер: US20120010364A1
Автор: Adam Gregg Malofsky, Bernard Miles Malofsky, Gregory Stephen Kulibert, Michael Curley Krzoska, Nagib Maurice Ward, Todd Arlin Schwantes
Принадлежит: Appleton Papers Inc

Encapsulated cure systems are provided wherein a curative is incorporated into a solid or semi-solid carrier material whereby mere fracturing or failure of the capsule wall encapsulating such cure systems will not provide for or allow sufficient release of the curative. Also provided are adhesive systems incorporating said encapsulated cure systems.

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Номер записи: 7
19-01-2012 дата публикации

Electrospinning manufacture for drug carriers

Номер: US20120013046A1
Автор: Chih-Hui Yang, Keng-Shiang Huang, Yung-Sheng Lin
Принадлежит: I-SHOU UNIVERSITY

An electrospinning manufacture for drug carriers is disclosed. The method comprises a preliminary step mixing a predetermined drug, an alginate, and a saline to obtain a mixture; an electric field establishing step providing a collection plate and an emitter filled with divalent cation agent and the mixture individually, wherein an electric field is applied to the collection plate and the emitter to form a voltage therebetween; and an electrospinning step sequentially dropping the mixture from the emitter into the divalent cation agent filled in the collection plate via the driving of the electric field, triggering a crosslinking-gelating reaction between the divalent cation and the alginate, wherein a plurality of gel particles is produced for a coating of the predetermined drug presenting a drug carrier performance.

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Номер записи: 8
19-01-2012 дата публикации

Microencapsulated catalyst

Номер: US20120016139A1
Автор: Mohammed Nisar, Thomas Eric Oliver Screen
Принадлежит: REAXA Ltd

The present invention relates to a catalyst system. In particular the invention relates to a catalyst in the form of metal or an alloy that is encapsulated within a polymer shell or matrix. More specifically the invention is directed towards reactive catalytic metals that may be pyrophoric or otherwise reactive in air and/or susceptible to oxidation. In particular, the invention is concerned with catalysts based on nickel. Raney or sponge nickel is highly hazardous: a self-igniting solid; produces hazardous fumes when burning; causes irritation of the respiratory tract, nasal cavities; causes pulmonary fibrosis if inhaled; ingestion may lead to convulsions and intestinal disorders; causes eye and skin irritation; and chronic exposure may lead to pneumonitis and sensitization (“nickel itch”). The invention provides metal catalysts that avoid such problems and have a good shelf life and working life.

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Номер записи: 9
19-01-2012 дата публикации

Process for preparing a core-layer material having good mechanical strength

Номер: US20120016170A1
Автор: Antoine Fecant, Lars Fischer, Loic Rouleau, Mehrdji Hemati, Samy Ould-Chikh
Принадлежит: IFP Energies Nouvelles IFPEN

A process is described for preparing a spherical material comprising a porous core coated with a continuous and homogeneous porous layer, the degree of attrition of said material being less than 20%. Said preparation process comprises a) bringing a bed of spherical particles constituting the core of said material into contact with a suspension containing an inorganic binder in order to form a solid having a pre-layer around said core; b) bringing the solid derived from step a) into contact, in a stream of hot air, with a powder constituted by spherical particles of an inorganic oxide and a suspension containing an inorganic binder and an organic binder in order to form a solid the core of which is coated with at least one continuous and homogeneous porous layer, the ratio of the (mass of anhydrous inorganic binder/volume of powder particles) being in the range 0.05 to 1 g.mL −1 ; c) drying the solid derived from said step b); and d) calcining the solid derived from said step c).

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Номер записи: 10
29-03-2012 дата публикации

Delivery of Herbicidal Actives From Highly Charged Microcapsules

Номер: US20120074603A1
Автор: Daniel H. Traynor, Henry G. Traynor
Принадлежит: Individual

This invention relates to a method for forming hollow silica-based particles suitable for containing one or more herbicidal active ingredients. In the method for forming the herbicidal composition, an emulsion is prepared wherein the emulsion includes a continuous phase that is polar or non-polar, and a dispersed phase comprising droplets including (i) a polar herbicidal active ingredient when the continuous phase is non-polar or (ii) a non-polar herbicidal active ingredient when the continuous phase is polar. A silica precursor is added to the emulsion such that the silica precursor can be emulsion templated on the droplets to form hollow silica-based particles that encapsulate the herbicidal active ingredient,

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Номер записи: 11
10-05-2012 дата публикации

Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein

Номер: US20120114707A1
Автор: Trevor P. Castor
Принадлежит: Individual

This invention is an improved process to formulate polymeric microspheres/nanospheres and encapsulate therapeutic proteins or other useful substances, and a polymer sphere apparatus. The invention is also methods of purifying protein-containing-polymeric-microspheres from unused polymer, and an apparatus therefore.

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Номер записи: 12
23-08-2012 дата публикации

Preparation of polyphosphazene microspheres

Номер: US20120214951A1
Автор: Alexander K. Andrianov, Bryan E. Roberts
Принадлежит: Individual

Methods of producing polyphosphazene microspheres comprising admixing aqueous solutions of a water-soluble polyphosphazene and an organic amine, or salt thereof, are disclosed.

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Номер записи: 13
08-11-2012 дата публикации

Silica particle including a molecule of interest, method for preparing same and uses thereof

Номер: US20120283379A1
Автор: Aurelien Auger, Chloe Schubert, Jorice Samuel, Olivier Jean Christian Poncelet, Olivier Raccurt, Sylvie Sauvaigo
Принадлежит: Commissariat a lEnergie Atomique et aux Energies Alternatives CEA

What is provided includes a nanoparticle of porous silica, incorporating at least one molecule of interest, the silica network inside said nanoparticle being functionalized by at least one group capable of setting up an ionic and/or hydrogen non-covalent bond with the molecule of interest, whereby the molecule(s) of interest is(are) linked to the silica network solely by non-covalent bonds. In addition, a method for preparing said silica particle and uses thereof is provided.

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Номер записи: 14
27-12-2012 дата публикации

Microparticle dispersion liquid manufacturing method and microparticle dispersion liquid manufacturing apparatus

Номер: US20120328480A1
Автор: Gen Takebe, Mitsuo Hiramatsu, Tokio Takagi
Принадлежит: Hamamatsu Photonics KK

In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues are obtained by the organic solvent removal, and the residues are fixed on respective bottom surfaces of a plurality of locations of a container. In a water injecting step, water is injected into each of a plurality of recesses of the container. In an irradiating step, laser light L, emitted from a light irradiating unit, is irradiated simultaneously or successively on the residues fixed on the respective bottom surfaces of the recesses of the container, and the residues are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water, is manufactured.

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Номер записи: 15
14-03-2013 дата публикации

Process of treatment of fibers and/or textile materials

Номер: US20130064876A1
Автор: Alfonso FERNÁNDEZ BOTELLO, Josep LLuís VILADOT PETIT, Raquel DELGADO GONZÁLEZ
Принадлежит: Lipotec SA

A process of treatment of textile materials containing microcapsules of active ingredients, the fibers and/or textile materials resulting from this process and their cosmetic or pharmaceutical use and/or their use as a repellent.

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Номер записи: 16
21-03-2013 дата публикации

Compositions Comprising Solid Particles Entrapped In Collapsed Polymeric Microspheres, And Methods Of Making The Same

Номер: US20130071453A1
Автор: Cummins Phillip, Fthenakis Christina F., Sojka Milan F., Xavier Jean Harry
Принадлежит:

The present invention relates to topical compositions containing solid particles that are stabilized via entrapment by microspheres and methods for making the same. Each of the microspheres contains a collapsed polymeric shell that has entrapped therein one or more solid particles. The solid particles are preferably formed of zinc oxide or titanium dioxide or both, which can readily be used either alone or in combination with other sunscreen agents to form sunscreen compositions of broader UV protection spectrum and enhanced photostability. 1. A method for modifying or treating solid particles , comprising:(a) forming a gelled mixture by mixing either simultaneously or sequentially in any order (1) hollow microspheres each comprising a deformable polymeric shell having entrapped therein an expandable fluid, (2) a first organic solvent which is present in an amount sufficient to swell and implode the microspheres but not dissolve the polymeric shells of the hollow microspheres, and (3) solid particles, wherein molecules of the first solvent enter between polymeric chains of the polymeric shell and disrupt intermolecular bonds between the chains, forming micro-channels in the swelled polymer shells which substantially simultaneously allow entry of the solid particles into the hollow microspheres and exit of a first portion of the expandable fluid therefrom, thereby collapsing the microspheres and entrapping the solid particles therein;(b) introducing a second solvent which is miscible with the first solvent into the gelled mixture with sufficient agitation to quench the gelled mixture, thereby diluting the first solvent and permitting exit of a second portion of expandable fluid from the microspheres so as to form separated microspheres, each comprising a collapsed polymeric shell, having an average particle size in the range of from about 1 to about 50 microns, and having one or more of said solid particles entrapped therein; and(c) removing the expandable fluid and ...

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Номер записи: 17
21-03-2013 дата публикации

Particles which are surface coated with hyaluronan or one of the derivatives thereof and the use of same as biological vectors for active substances

Номер: US20130071480A1
Автор: DELLACHERIE Edith, Gref Ruxandra, Leonard Michele, Netter Patrick, Payan Elisabeth
Принадлежит: Centre National De La Recherche Scientifique

Particles having a core based on at least one biodegradable organosoluble polymer. At least a part of the surface of the particles is coated with at least one hyaluronan or a derivative thereof, the hyaluronan being a water-soluble, amphiphilic hyaluronan of which the carboxylic functions are in part transformed to form hydrophobic groups. 1. A method of preparing particles encapsulating a hydrophobic active substance , comprising: dissolving a biodegradable polymer in en organic phase with the hydrophobic active substance to be encapsulated,', 'dissolving an amphiphilic hyaluronan in an aqueous phase, the aqueous phase being a dispersing medium for the organic phase, and', 'mixing the organic phase and the aqueous phase;, 'preparing a single emulsion includingevaporating off an organic solvent; andrecovering the particles encapsulating the hydrophobic active substance.2. The method of claim 1 , further comprising washing the particles with water.3. The method of claim 1 , farther comprising subjecting the particles to centrifugation or lyophilization.4. The method of claim 1 , wherein the organic phase is a solvent that is barely soluble in water.5. The method of claim 4 , wherein the organic solvent is methylene chloride or ethyl acetate.6. The method of claim 1 , further comprising incorporating a diagnostic compound into the particles.7. The method of claim 6 , wherein the diagnostic compound comprises at least one substance capable of being detected by X-rays claim 6 , fluorescence claim 6 , ultrasound claim 6 , substances nuclear magnetic resonance claim 6 , or radioactivity.8. The method of claim 6 , wherein incorporating the diagnostic material occurs during formation of the particles claim 6 ,9. A method of preparing particles encapsulating a hydrophilic active material claim 6 , comprising: the organic phase contains a biodegradable organosoluble polymer, and', 'the first aqueous phase contains the hydrophilic active material to be encapsulated;, ' ...

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Номер записи: 18
21-03-2013 дата публикации

Thermally Robust Capsule System, And Composites Including The Capsules

Номер: US20130072596A1
Автор: Blaiszik Benjamin J., Caruso Mary M., Moore Jeffrey S., Sottos Nancy R., White Scott R.
Принадлежит: The Board of Trustees of the University of Illinois

A method of making capsules includes forming a mixture including a core liquid, a polyurethane precursor system, a first component of a two-component poly(urea-formaldehyde) precursor system, and a solvent. The method further includes emulsifying the mixture, adding a second component of the two-component poly(urea-formaldehyde) precursor system to the emulsified mixture, and maintaining the emulsified mixture at a temperature and for a time sufficient to form a plurality of capsules that encapsulate at least a portion of the core liquid. The capsules made by the method may include a polymerizer in the capsules, where the capsules have an inner capsule wall including a polyurethane, and an outer capsule wall including a poly(urea-formaldehyde). The capsules may include in the solid polymer matrix of a composite material. 1. A method of making capsules , comprising: a core liquid,', 'a polyurethane precursor system,', 'a first component of a two-component poly(urea-formaldehyde) precursor system, and', 'a solvent;, 'forming a mixture comprising'}emulsifying the mixture;adding a second component of the two-component poly(urea-formaldehyde) precursor system to the emulsified mixture; andmaintaining the emulsified mixture at a temperature and for a time sufficient to form a plurality of capsules that encapsulate at least a portion of the core liquid.2. The method of claim 1 , where the core liquid is selected from the group consisting of a polymerizer and an activator for a polymerizer.3. The method of claim 1 , where the polyurethane precursor system comprises a polyisocyanate and a first polyol;the first component of the two-component poly(urea-formaldehyde) precursor system comprises urea, a base, a second polyol and an anhydride; andthe second component of the two-component poly(urea-formaldehyde) precursor system comprises formaldehyde.4. The method of claim 3 , where the first and second polyol are identical.5. The method of claim 1 , where the solvent comprises ...

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Номер записи: 19
28-03-2013 дата публикации

ENCAPSULATION DEVICE, MEDICAL CAPSULES, AND ENCAPSULATION METHOD

Номер: US20130078308A1
Автор: Fukui Yoshiki, Hashimoto Taki
Принадлежит: SEIKO EPSON CORPORATION

An encapsulation device includes: a fluid injection device that injects a first liquid forming a core; a liquid film holder that holds in film form a second liquid forming a shell containing the core; and a liquid contact device that makes the shell in contact with a third liquid, in which the first liquid is injected toward a liquid film of the second liquid retained by the liquid film holder to form a core, the core is wrapped with the second liquid on passing through the liquid film of the second liquid, thereby forming the shell, and the shell is made in contact with the third liquid to induce chemical reaction. 1. An encapsulation device comprising:a fluid injection device that injects a first liquid forming a core;a liquid film holder that holds in film form a second liquid forming a shell containing the core; anda liquid contact device that makes the shell in contact with a third liquid,the first liquid being injected toward a liquid film of the second liquid retained by the liquid film holder to form a core,the core being wrapped with the second liquid on passing through the liquid film of the second liquid, thereby forming the shell, andthe shell being made in contact with the third liquid to induce chemical reaction.2. The encapsulation device according to claim 1 , whereinthe liquid contact device has a liquid reservoir that reserves the third liquid in liquid form, andthe second liquid is made in contact with the third liquid by making the core wrapped with the second liquid to enter the liquid reservoir.3. The encapsulation device according to claim 1 , whereinthe liquid contact device has a mist generator that mists the third liquid in mist form, andthe second liquid is made in contact with the third liquid by misting the third liquid from the mist generator to an area, toward which the core wrapped with the second liquid is moved.4. The encapsulation device according to claim 2 , whereinthe second liquid is an aqueous solution containing a ...

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Номер записи: 20
11-04-2013 дата публикации

LOCALIZATION OF AGENTS AT A TARGET SITE WITH A COMPOSITION AND AN ENERGY SOURCE

Номер: US20130090591A1
Автор: FERRARA Katherine W., Kheirolomoom Azedah
Принадлежит: The Regents of the University of California

A method for localizing delivery of an agent to a target site in a subject is provided. The method allows accumulation and/or release of the agent at the target site in the subject through the use of an energy source. 1. A method for localized delivery of an agent to a target site , comprising:administering a composition to a subject, wherein the subject comprises the target site and the composition comprises an agent-transition metal complex; andirradiating the target site with an energy source, the irradiating causing accumulation of the agent-transition metal complex at the target site or release of the agent-transition metal complex from the composition at the target site, thereby producing localized delivery of the agent to the target site.2. The method of claim 1 , wherein the administered composition further comprises a liposome comprising a 63:7:25:5 molar ratio of DPPC:DSPC:chol:DSPE-PEG2k claim 1 , wherein the liposome comprises the complex claim 1 , wherein the agent is doxorubicin claim 1 , wherein the transition metal is copper (II) claim 1 , wherein the energy source is ultrasound claim 1 , wherein the target site comprises a tumor claim 1 , and wherein the method further comprises administering rapamycin to the subject.3. The method of claim 1 , wherein the agent is doxorubicin.4. The method of claim 1 , wherein the agent is an anthracycline.5. The method of claim 4 , wherein the anthracycline is selected from the group consisting of: daunorubicin claim 4 , doxorubicin claim 4 , epirubicin claim 4 , idarubicin claim 4 , mitoxantrone claim 4 , valrubicin claim 4 , and irinotecan.6. The method of claim 3 , wherein the transition metal is copper.7. The method of claim 6 , wherein the molar ratio of doxorubicin to copper in the composition is 2:1.8. The method of claim 6 , wherein the molar ratio of doxorubicin to copper in the composition is 1:1.9. The method of claim 3 , wherein the doxorubicin concentration in the composition is less than 50 mM claim 3 ...

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Номер записи: 21
18-04-2013 дата публикации

PROCESS FOR THE PREPARATION OF CONTROLLED-RELEASE SOLID FORMULATIONS CONTAINING OXCARBAZEPINE, AND FORMULATIONS OBTAINABLE BY SAID PROCESS

Номер: US20130095149A1
Автор: "SANSO Giovanni", BANFI Aldo, Bertolini Giorgio, SILVA Claudio
Принадлежит: ARCHIMICA S.R.L.

The present invention relates to a process for the preparation of controlled-release solid oral pharmaceutical formulations of oxcarbazepine, and the pharmaceutical formulations obtainable by said process. 1. A process for the preparation of controlled-release solid oral pharmaceutical formulations of oxcarbazepine which comprises:a) dissolving the oxcarbazepine and mixtures of mono-, di- and triglycerides in an organic solvent miscible with water to obtain a solution;b) adding an aqueous suspension of water-insoluble excipients to the solution obtained in a) to obtain a wet microcrystalline co-precipitate;c) adding any water-soluble excipients to the wet microcrystalline co-precipitate obtained in b) and granulating the resulting mixture; andd) compressing or distributing the granulate obtained in c) in the pharmaceutical administration form.2. The process as claimed in claim 1 , wherein step b) is performed at a temperature of between 0 and 8° C.3. The process as claimed in claim 2 , wherein the microcrystalline co-precipitate obtained has an average particle-size distribution of approximately 50 μm.4. The process as claimed in claim 1 , wherein the organic solvent miscible with water is dimethylformamide.5. The process as claimed in claim 1 , wherein the water-insoluble excipients are selected from microcrystalline cellulose and derivatives thereof claim 1 , methylcellulose claim 1 , hydroxypropyl methylcellulose claim 1 , ethylcellulose claim 1 , pineapple fibres claim 1 , talc claim 1 , colloidal silicon dioxide claim 1 , calcium phosphate claim 1 , magnesium phosphate claim 1 , milk protein claim 1 , soy proteins and gelatin.6. The process as claimed in claim 1 , wherein the water-soluble excipients to be added at step c) are selected from mannitol claim 1 , xylitol claim 1 , maltodextrins claim 1 , sodium carboxymethylcellulose claim 1 , polyethylene glycols claim 1 , agar agar and mixtures thereof.7. Pharmaceutical compositions obtainable by the process as ...

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Номер записи: 22
18-04-2013 дата публикации

Process For Producing Microcapsules

Номер: US20130095158A1
Автор: Denuell Wolfgang, Hotz Jutta
Принадлежит: Cognis IP Management GmbH

The application describes a process for producing microcapsules which contain a shell made of polyurea and which surround in their interior a water-insoluble oil, where the shell is obtained by the reaction of two structurally different diisocyanates in emulsion form. 1. A process for producing microcapsules which contain a shell and a core of a liquid , water-insoluble material , the process comprising:bringing together an aqueous solution of a protective colloid and a solution of a mixture of at least two structurally different at least difunctional diisocyanates (A) and (B) in a water-insoluble liquid until an emulsion is formed;adding an at least difunctional amine to the emulsion; andheating to a temperature of at least 60° C. until the microcapsules are formed,wherein the isocyanate (B) is selected from the anionically modified isocyanates or the polyethylene oxide-containing isocyanates and the isocyanate (A) is uncharged and is not a polyethylene oxide-containing isocyanate.2. The process of claim 1 , wherein the protective colloid comprises a polyvinylpyrrolidone.3. The process of claim 1 , wherein the isocyanate (A) is selected from the group consisting of hexane 1 claim 1 ,6-diisocyanate claim 1 , hexane 1 claim 1 ,6-diisocyanate biuret claim 1 , or oligomers of hexane 1 claim 1 ,6-diisocyanate.4. The process of claim 1 , wherein the isocyanate (B) is selected from the group of anionically modified diisocyanates which contain at least one sulfonic acid group.5. The process of claim 1 , wherein the at least difunctional amine comprises a polyethyleneimine.6. The process of claim 1 , wherein the weight ratio between the isocyanates (A) and (B) is in the range of from 10:1 to 1:10.7. The process of claim 1 , wherein the core-shell ratio (w/w) of the microcapsules is 20:1 to 1:10.8. The process of claim 1 , further comprising:(a) preparing a first premix (I) from water and the protective colloid;(b) adjusting a pH of the first premix in the range of from 5 to ...

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Номер записи: 23
30-05-2013 дата публикации

METHOD OF PRODUCING NANO- AND MICROCAPSULES OF SPIDER SILK PROTEIN

Номер: US20130136779A1
Автор: Bausch Andreas, Hermanson Kevin, Huemmerich Daniel, Scheibel Thomas
Принадлежит: AMSILK GMBH

The present invention is directed to a method of producing nano- and microcapsules from spider silk proteins The invention is further directed to nano- or microcapsules obtainable by this method as well as pharmaceutical, cosmetical and food compositions containing same. 1. A nanocapsule of spider silk proteins , wherein the spider silk proteins form a polymer network that encapsulates an emulsion droplet.2. The nanocapsule of spider silk proteins of claim 1 , wherein said nanocapsule has a wall.3. The nanocapsule of spider silk proteins of claim 2 , wherein the wall thickness of said nanocapsule is between 5 and 100 nm.4. The nanocapsule of spider silk proteins of claim 1 , wherein the spider silk proteins comprise 5 to 50 repeat units claim 1 , wherein the repeat unit is selected from the group consisting of the amino acid sequence according to SEQ ID NO: 3 claim 1 , the amino acid sequence according to SEQ ID NO: 4 claim 1 , and the amino acid sequence according to SEQ ID NO: 5.5. The nanocapsule of spider silk proteins of claim 1 , wherein the spider silk proteins are selected from the group consisting of C claim 1 , C claim 1 , (AQ) claim 1 , (AQ) claim 1 , (QAQ)and (QAQ) claim 1 , wherein C represents the amino acid sequence according to SEQ ID NO: 5 claim 1 , A represents the amino acid sequence according to SEQ ID NO: 3 and Q represents the amino acid sequence according to SEQ ID NO: 4.6. The nanocapsule of spider silk proteins of claim 1 , wherein the nanocapsule comprises pharmaceutical agents claim 1 , cosmetical agents claim 1 , foodstuffs or food additives.7. The nanocapsule of spider silk proteins of claim 6 , wherein the pharmaceutical agents claim 6 , cosmetical agents claim 6 , foodstuffs or food additives are encapsulated in the nanocapsule.8. The nanocapsule of spider silk proteins of claim 6 , wherein the nanocapsule is coated by the pharmaceutical agents claim 6 , cosmetical agents claim 6 , foodstuffs or food additives.9. A microcapsule of ...

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Номер записи: 24
30-05-2013 дата публикации

Microcapsules and production thereof

Номер: US20130137626A1
Автор: Daniel Mues, Klaus Last
Принадлежит: Follmann and Co Gesellschaft fur Chemie Werkstoffe und Verfahrenstechnik mbH and Co KG

The invention relates to microcapsules, the capsule walls of which comprise a resin that can be obtained by reacting a) at least one compound selected from the group consisting of a1) amines and a2) aromatic or heteroaromatic compounds which are unsubstituted or substituted with one or more substituents from the group consisting of C 1 -C 20 -alkyl, OH, OR, COOH, SH, SR, NHCOR, OCOR, halogen, or an aromatic compound, where R is a C 1 -C 10 -alkyl group, with b) at least one aldehydic component that contains at least two carbons atoms per molecule, in the presence of c) at least one copolymer which contains units of 2-acrylamido-2-methylpropane sulphonic acid or salts (AMPS) thereof and/or 2-acrylamido-2-methylpropane phosphonic acid or salts (AMPP) thereof and units of one or more (meth)acrylates.

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Номер записи: 25
06-06-2013 дата публикации

BECLOMETHASONE DIPROPIONATE COMPOSITIONS IN MODIFIED-RELEASE GASTRO-RESISTANT MICROSPHERES AND PROCESS FOR OBTAINING THEM

Номер: US20130142880A1
Автор: LABRUZZO Carla
Принадлежит: SOFAR SPA

The present invention refers to pharmaceutical beclomethasone dipropionate compositions in modified-release gastro-resistant microspheres and to their oral use in the treatment of inflammatory pathologies of the intestinal tract. Said compositions in microspheres comprise: a) a core consisting of a microsphere of inert material; b) a first intermediate coating comprising beclomethasone dipropionate and at least one physiologically acceptable excipient; c) a second modified-release gastro-resistant coating. The present invention also refers to a process for obtaining said compositions. 1. A pharmaceutical composition in modified-release gastro-resistant microspheres , each microsphere comprising:a) a core consisting of a microsphere of inert material;b) a first intermediate coating comprising beclomethasone dipropionate and at least one physiologically acceptable excipient;c) a second modified-release gastro-resistant coating.2. A pharmaceutical composition according to claim 1 , wherein said microsphere of inert material has an average particle size of between 100 and 1000 microns claim 1 , preferably between 350 and 500 microns.3. A pharmaceutical composition according to claim 2 , wherein said inert material is a diluent.4. A pharmaceutical composition according to claim 3 , wherein said diluent is selected from microcrystalline cellulose claim 3 , saccharose claim 3 , corn starch claim 3 , lactose and/or a mixture thereof.5. A pharmaceutical composition according to claim 1 , wherein said at least one physiologically acceptable excipient is selected from suspending agents and/or glidants claim 1 , filming agents claim 1 , plasticizing agents and/or a mixture thereof6. A pharmaceutical composition according to claim 5 , wherein said suspending agents and/or glidants are selected from colloidal anhydrous silica claim 5 , talc and/or a mixture thereof.7. A pharmaceutical composition according to claim 5 , wherein said filming agents are selected from alkyl cellulose ...

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Номер записи: 26
20-06-2013 дата публикации

Formulations Preserving Bioactivity and Methods of Their Preparation

Номер: US20130156858A1
Автор: Lilyan Yachoh, Per Wikstrom, Tobias Bramer
Принадлежит: RPH Pharmaceuticals AB

A pharmaceutical composition comprising an alginate hydrogel core where a bioactive agent is entrapped. The water content of the hydrogel is at least 10% of equilibrium water content. The beads have an enteric coating and are intended for oral administration. The bioactive agent is bioactive proteins, antibodies or viable cells and it is intended to exert its activity in the duodenum and the upper intestines.

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Номер записи: 27
27-06-2013 дата публикации

Porous Metal Oxide Particles and Their Methods of Synthesis

Номер: US20130164536A1
Автор: Chen Fanglin, Liu Qiang
Принадлежит: UNIVERSITY OF SOUTH CAROLINA

Methods are generally disclosed for synthesis of porous particles from a solution formed from a leaving agent, a surfactant, and a soluble metal salt in a solvent. The surfactant congregates to form a nanoparticle core such that the metal salt forms about the nanoparticle core to form a plurality of nanoparticles. The solution is heated such that the leaving agent forms gas bubbles in the solution, and the plurality of nanoparticles congregate about the gas bubbles to form a porous particle. The porous particles are also generally disclosed and can include a particle shell formed about a core to define an average diameter from about 0.5 μm to about 50 μm. The particle shell can be formed from a plurality of nanoparticles having an average diameter of from about 1 nm to about 50 nm and defined by a metal salt formed about a surfactant core. 1. A porous particle comprising a particle shell formed about a core to define an average diameter from about 0.5 μm to about 50 μm , wherein particle shell comprises a plurality of nanoparticles having an average diameter of from about 1 nm to about 50 nm , wherein the nanoparticles are defined by a metal salt formed about a surfactant core , and wherein the surfactant core comprises a surfactant molecule having a hydrophobic tail and a hydrophilic head.2. The porous particle of claim 1 , wherein the surfactant comprises a block copolymer.3. The porous particle of claim 2 , wherein the surfactant comprises poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol).4. The porous particle of claim 1 , wherein the metal salt comprises a metal oxide.5. The porous particle of claim 1 , wherein the metal salt comprises a metal nitrate.6. The porous particle of claim 1 , wherein the metal salt comprises a metal acetate.7. The porous particle of claim 6 , wherein the metal salt comprises a metal ion formed from cobalt claim 6 , cerium claim 6 , strontium claim 6 , iron claim 6 , samaria claim 6 , lanthanum claim 6 , ...

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Номер записи: 28
18-07-2013 дата публикации

PROCESS FOR MANUFACTURING POLYSILOXANE MICROCAPSULES THAT ARE FUNCTIONALIZED AND ARE NOT VERY POROUS

Номер: US20130181363A1
Автор: Bouazza Vincent, Monfray Jeremy, RAYNAUD Elodie, Robert Peggy, Viaud-Massuard Marie-Claude
Принадлежит: UNIVERSITE DE TOURS FRANCOIS RABELAIS

A method is provided for encapsulating products that can have lipophilic or hydrophilic, including volatile, properties in a polysiloxane membrane that is particularly impervious. A method is also provided for evaluating the imperviousness of capsules. The present method includes the following steps: 1. A method for encapsulating one or more products that can have lipophilic or hydrophilic properties in a polysiloxane membrane , comprising the following steps:a) formation of droplets by an emulsion between an oily phase containing the product to be encapsulated and an acidic aqueous phase heated between 40° C. and 70° C., and in the presence of surfactants;b) addition and hydrolysis of at least one silane in order to obtain a silanol;c) increasing the pH in order to start condensation of the silanol to form a first membrane around the droplets of the product to be encapsulated;d) lowering the pH; ande) increasing the pH in order to obtain new or better condensation of the silanol around the droplets of the product to be encapsulated.2. The method according to claim 1 , characterized in that step e) further comprises the addition of at least one silane.3. The method according to claim 1 , characterized in that at least one silane added during step e) is a silane different from the silane or silanes added during step b) claim 1 , thus forming a second membrane around the droplets of the product to be encapsulated during the new condensation of silanol during step e).5. The The method according to any one of the claim 1 , characterized in that one or more silanes used in step b) claim 1 , or step e) claim 1 , or both claim 1 , is selected from the following substances:(3-(trimethoxysilyl)propyl)diethylenetriamine, (3-chloropropyl)triethoxysilane,1-[3-(trimethoxysilyl)]-propylurea,3-[2-(2-aminoethylamino)ethylamino]propyltrimethoxysilane,3-aminopropyldiethoxymethylsilane, 3-aminopropylmethyldiethoxysilane,3-aminopropyltriethoxysilane, 3-aminopropyltrimethoxysilane,3- ...

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Номер записи: 29
18-07-2013 дата публикации

Microencapsulated Volatile Insect Repellent and/or Insecticide Agent and Methods of Making and Using the Same

Номер: US20130185817A1
Автор: Langley Jeffrey T., Massey Troy S.
Принадлежит:

This disclosure is particularly directed to arthropodal compositions in the form of capsules containing an active arthropod agent, more particularly to capsules containing an active arthropod agent and methods of making and using the same. The active arthropod agent may be an insect repellent and/or an insecticide agent. 1. A composition , comprising:a wall defining a void volume, wherein the wall comprises a polymeric material; andan active arthropod agent filing at least some of the void volume, wherein the wall one or both of is permeable to and controls the release of active arthropod agent.2. The composition of claim 1 , wherein the active arthropod agent has a calculated vapor pressure at 25 degrees Celsius of more than about 1×10mm Hg and wherein the composition is in the form of capsules having an average capsule size of no more than about 1 claim 1 ,000 μm.3. The composition of claim 1 , wherein the active arthropod agent is a fatty acid having six or more carbon atoms or a mixture of fatty acids having six or more carbon atoms.4. The composition of claim 1 , wherein the active arthropod agent comprises one of:{'sub': 8', '9', '10, 'i) one or more of a Cfatty acid, Cfatty acid, and Cfatty acid; or'}{'sub': 6', '7', '8', '9', '10, 'ii) one or more of a Cfatty acid, Cfatty acid, Cfatty acid, Cfatty acid, and Cfatty acid.'}5. The composition of claim 1 , wherein the wall material comprises one of a polyurethane claim 1 , polyurea claim 1 , urea-formaldehyde claim 1 , urea-resorcinol-formaldehyde claim 1 , melamine formaldehyde or combination thereof.6. The composition of claim 1 , wherein the wall material comprises melamine formaldehyde.7. The composition of claim 1 , wherein the capsules have an average capsule size from about 1 to about 100 μm.8. The composition of claim 1 , wherein the active arthropod agent fills more than about 90% of the void volume.9. A device claim 1 , comprising:a target substrate;a capsule positioned one or both of on and in the ...

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Номер записи: 30
25-07-2013 дата публикации

METHOD OF DRUG FORMULATION BASED ON INCREASING THE AFFINITY OF ACTIVE AGENTS FOR CRYSTALLINE MICROPARTICLE SURFACES

Номер: US20130189365A1
Автор: Hokenson Mark, Oberg Keith A.
Принадлежит: MANNKIND CORPORATION

Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle. 1. A method of promoting binding of an active agent to a preformed crystalline diketopiperazine microparticle in suspension comprising:modifying the chemical potential of the active agent by modifying the structure, flexibility, rigidity, solubility or stability of the active agent to allow for an energetically favorable interaction between the active agent and the preformed crystalline diketopiperazine microparticle independent of removal of solvent;wherein said modifying step causes adsorption of said active agent onto a surface of said preformed crystalline diketopiperazine microparticle to provide a coating of said active agent on said preformed crystalline diketopiperazine microparticle, said preformed crystalline diketopiperazine microparticle does not comprise an active agent, and said active agent comprises an antibody or fragment thereof.2. The method of wherein the antibody or fragment thereof is humanized or chimeric.3. The method of wherein the antibody or fragment thereof comprises F(ab) claim 1 , F(ab)2 claim 1 , or a single-chain antibody.4. The method of wherein the antibody or fragment thereof is fused to a polypeptide.5. The method of wherein the antibody or fragment thereof can recognize a disease-associated antigen.6. The method of wherein the disease-associated antigen is a tumor-associated antigen or an infectious pathogen-related antigen.7. The method of wherein the disease-associated antigen is one of cancer antigens claim 5 , cytokines claim 5 , infectious agents claim 5 , inflammatory mediators claim 5 , hormones claim 5 , and cell surface antigens.8. The method of wherein the antibody or fragment thereof is one of anti-SSX-2(synovial sarcoma claim 7 , X breakpoint 2) claim 7 , anti-NY-ESO-1 (esophageal tumor associated antigen) ...

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Номер записи: 31
01-08-2013 дата публикации

WATER-SOLUBLE MELOXICAM GRANULES

Номер: US20130193028A1
Автор: Folger Martin A., HENKE Stefan, HERZ Nina, Keilhofer Diana C., KROFF Hans-Juergen, Lehmann (nee Schmalz) Jens
Принадлежит: BOEHRINGER INGELHEIM VETMEDICA GMBH

Water soluble meloxicam granules include meloxicam, a salt forming agent which forms the meglumine, sodium, potassium, or ammonium salt of meloxicam, a binder, a sugar or sweetener, and a carrier, and a flavoring agent. 1. A method of treating animals comprising administering water soluble granules to an animal , the water soluble granules comprising meloxicam; a salt forming agent operable to form a meloxicam salt; a binder; and a carrier.2. The method according to further comprising dissolving the water soluble granules in water prior to administration.3. The method according to further comprising mixing the water soluble granules with animal feed prior to administration.4. The method according to claim 1 , wherein the salt forming agent is selected from the group consisting of meglumine claim 1 , sodium claim 1 , potassium claim 1 , or ammonium meloxicam salt.5. The method according to claim 1 , wherein the salt forming agent is meglumine.6. The method according to claim 1 , wherein the binder is selected from hydroxypropylmethylcellulose claim 1 , polyvinylpyrrolidone claim 1 , gelatine claim 1 , starch claim 1 , or polyethylene glycol ether.7. The method according to claim 6 , wherein the binder is present in an amount of 20 mg/g to 150 mg/g.8. The method according to claim 1 , wherein the water soluble granules are administered in conjunction with antibiotic treatment.9. The method according to claim 1 , wherein the animal includes horses claim 1 , pigs claim 1 , cattle claim 1 , dogs claim 1 , or cats.10. The method according to claim 1 , wherein the meloxicam granules comprises meloxicam claim 1 , meglumine claim 1 , hydroxypropylmethylcellulose claim 1 , povidone claim 1 , and glucose monohydrate.11. The method according to claim 1 , wherein the granules possess a particle size distribution of 125 μm to 500 μm.12. The method according to claim 1 , wherein:the salt forming agent is meglumine;the molar ratio of meglumine and meloxicam is 9:8 to 12:8.13. An ...

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Номер записи: 32
01-08-2013 дата публикации

METHOD FOR FORMULATING LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES

Номер: US20130195965A1
Автор: Los Kathleen D.A., McGuire Ronald Warren, Schutt Ernest George, Walters Peter Andrew
Принадлежит: PACIRA PHARMACEUTICALS, INC.

The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated. 1. An atomizing nozzle apparatus , comprising:a first fluid conduit and a second fluid conduit each having at least one entrance orifice and at least one exit orifice;a fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and connecting to the at least one exit orifice of the first fluid conduit; anda third fluid conduit, wherein the third fluid conduit annularly surrounds a portion of the fluid contacting chamber.2. The atomizing nozzle of claim 1 , wherein the fluid contacting chamber connects to the at least one exit orifice of the second fluid conduit.3. The atomizing nozzle of claim 1 , wherein the at least one exit orifice of the fluid contacting chamber and the at least one exit orifice of the third fluid conduit are flush.4. The atomizing nozzle of claim 1 , wherein the at least one exit orifice of the fluid contacting chamber is recessed within the at least one exit orifice of the third fluid conduit.5. The atomizing nozzle of claim 1 , wherein the at least one exit orifice of the fluid contacting chamber extends beyond the at least one exit orifice of the third fluid conduit.6. The atomizing nozzle of claim 1 , wherein the first fluid conduit and the second fluid conduit are co-axial for a first portion of the first fluid conduit ...

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Номер записи: 33
01-08-2013 дата публикации

New Particles of Tetracyclines and Protecting Agent

Номер: US20130195986A1
Автор: de Faria Cristina Maria Sanches Simoes, Heggie William
Принадлежит: HOVIONE INTER LTD

Particles containing a tetracycline or one of its pharmaceutically acceptable salts and an antioxidant, formulations containing the same and their use in the treatment of infectious diseases are described. Methods of encapsulation of a tetracycline or one of its pharmaceutically acceptable salts and an antioxidant are also disclosed. 1. A particle comprising a tetracycline and an antioxidant characterized in that the tetracycline and the antioxidant are encapsulated in a polymeric material , wherein , in use , the tetracycline and the antioxidant are delivered simultaneously in precise and fixed proportions.2. A particle according to characterized in that the tetracycline is doxycycline claim 1 , minocycline claim 1 , tigecycline or tetracycline or one of their pharmaceutically acceptable salts.3. A particle according to wherein the tetracycline is doxycycline or minocycline or a pharmaceutically acceptable salt thereof.4. A particle according to claim 1 , characterized in that the antioxidant is ascorbic acid (vitamin C); a tocopherol or a tocotrienol such as vitamin E; a carotene; a flavonoid such as quercetin or a mixture of one or more of the above.5. A particle according to claim 1 , wherein the antioxidant is ascorbic acid (vitamin C) or quercetin.6. A particle according to claim 1 , characterized in that the polymer is a polysaccharide such as a starch claim 1 , a maltodextrine or gum arabic claim 1 , a lipid such as stearic acid or a mono or diglyceride claim 1 , a protein such as gelatin claim 1 , casein or soy claim 1 , a polymer such hydroxypropylmethyl cellulose or its derivatives claim 1 , polymethacrylate or its derivatives claim 1 , polyvinylpyrrolidone or its derivatives claim 1 , polyethyleneglycol or its derivatives; or a mixture of one or more of the above.7. A particle according to wherein the polymer is a hydropropylmethyl cellulose derivative such as hydropropylmethyl cellulose acetate succinate.8. A particle according to claim 1 , ...

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Номер записи: 34
01-08-2013 дата публикации

Microencapsulation of reactive diisocyanates and the application to self-healing anticorrosion coatings

Номер: US20130196071A1
Автор: Jinglei YANG, Mingxing Huang
Принадлежит: NANYANG TECHNOLOGICAL UNIVERSITY

The disclosure provides a polyurethane microcapsule consisting of a polymerization product of methylene diphenyl diisocyanate (MDI) prepolymer with a polyol, the polyurethane microcapsule comprising a liquid isocyanate compound encapsulated within the microcapsule. The disclosure also provides self-healing coating compositions comprising such polymeric microcapsules and methods of preventing or slowing corrosion using such coating compositions.

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Номер записи: 35
15-08-2013 дата публикации

Novel method for producing nanocapsules in the absence of an organic solvent, and nanocapsules produced thereby

Номер: US20130207286A1
Автор: Fabrice Pirot, Francoise Falson
Принадлежит: Individual

A method for preparing an aqueous suspension of nanocapsules comprising an oily core surrounded by a polymeric shell, comprises mixing first and second phases, wherein the first oily phase comprises a hydrophobic polymer, an oil or a mixture of oils, at least one active ingredient, and a surfactant TA 1 . The oily phase is brought to a temperature T 1 higher than the melting point of the hydrophobic polymer, the hydrophobic polymer being miscible, at this temperature T 1 , with the mixture of the surfactant TA 1 and the oil or mixture of oils, and the active ingredient being miscible, soluble or solubilized in the mixture of the surfactant TA 1 and the oil or mixture of oils. The second polar phase comprises a hydrophilic polymer in the form of a hydrogel in an aqueous solution containing a surfactant TA 2 , to form the nanocapsules in an aqueous suspension.

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Номер записи: 36
15-08-2013 дата публикации

"NANOPARTICLES FOR THE ENCAPSULATION OF COMPOUNDS, PREPARATION THEREOF AND USE OF SAME"

Номер: US20130209530A1
Автор: AGÜEROS BAZO Maite, Esparza Catalán Irene, GONZÁLEZ FERRERO Carolina, GONZÁLEZ NAVARRO Carlos Javier, IRACHE GARRETA Juan Manuel, ROMO HUALDE Ana
Принадлежит:

The present invention relates to nanoparticles for encapsulating compounds, the preparation and uses thereof, comprising a casein matrix, a basic amino acid and a metal selected from a divalent metal, a trivalent metal and combinations thereof. Said nanoparticles can encapsulate a water soluble or fat soluble biologically active compound. The invention is applicable in the food, pharmaceutical and cosmetic sectors and in the nanotechnology sector. 1. A nanoparticle comprising a casein matrix , a basic amino acid and a metal selected from a divalent metal , a trivalent metal and combinations thereof.2. The nanoparticle according to claim 1 , wherein said basic amino acid is selected from the group consisting of arginine claim 1 , lysine claim 1 , histidine claim 1 , and mixtures thereof.3. The nanoparticle according to claim 1 , wherein said divalent metal is selected from the group consisting of calcium claim 1 , magnesium claim 1 , zinc claim 1 , iron in divalent form claim 1 , and combinations thereof claim 1 , preferably calcium.4. The nanoparticle according to claim 1 , further comprising a biologically active compound.57.-. (canceled)8. A process for producing nanoparticles comprising a casein matrix claim 1 , a basic amino acid and a metal selected from a divalent metal claim 1 , a trivalent metal and combinations thereof claim 1 , which comprises:a) preparing an aqueous solution containing a source of casein and a basic amino acid; andb) adding an aqueous solution of a metal selected from a divalent metal, a trivalent metal and combinations thereof to the solution of step a).9. A process for producing a nanoparticle comprising a casein matrix claim 1 , a basic amino acid claim 1 , a metal selected from a divalent metal claim 1 , a trivalent metal claim 1 , and combinations thereof and a biologically active compound claim 1 , which comprises:a) mixing (i) an aqueous solution containing a source of casein and a first basic amino acid with (ii) a solution ...

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Номер записи: 37
22-08-2013 дата публикации

NANOCAPSULES CONTAINING MICROEMULSIONS

Номер: US20130216596A1
Автор: Delgado Gonzalez Raquel, Fernández Botello Alfonso, Viladot Petit Josep LLuis
Принадлежит: LIPOTEC, S.A.

Delivery system based on polymeric nanocapsules which contain microemulsions, and their use in the preparation of pharmaceutical, cosmetic and/or alimentary compositions. 1. A Polymerically coated nanocapsules which contain microemulsions of water in liquid lipids and which comprise at least one hydrophilic active ingredient dissolved in the internal aqueous phase and wherein the polymeric coating is a complex coacervate.2. The nanocapsules according to claim 1 , wherein the liquid lipids are selected from the group formed by vegetable oils claim 1 , soybean oil claim 1 , sunflower oil claim 1 , corn oil claim 1 , olive oil claim 1 , palm oil claim 1 , cottonseed oil claim 1 , colza oil claim 1 , peanut oil claim 1 , coconut oil claim 1 , castor oil claim 1 , linseed oil claim 1 , borage oil claim 1 , evening primrose oil claim 1 , marine oils claim 1 , fish oils claim 1 , algae oils claim 1 , oils derived from petroleum claim 1 , mineral oil claim 1 , liquid paraffin claim 1 , vaseline claim 1 , short-chain fatty alcohols claim 1 , medium-chain aliphatic branched fatty alcohols claim 1 , fatty acid esters with short-chain alcohols claim 1 , isopropyl myristate claim 1 , isopropyl palmitate claim 1 , isopropyl stearate claim 1 , dibutyl adipate claim 1 , medium-chain triglycerides claim 1 , capric and caprylic triglycerides claim 1 , C12-C16 octanoates claim 1 , fatty alcohol ethers claim 1 , dioctyl ether and/or mixtures thereof.3. The nanocapsules according to claim 1 , wherein the polymer of the coating is selected from the group formed by proteins claim 1 , polysaccharides claim 1 , polyesters claim 1 , polyacrylates claim 1 , polycyanoacrylates claim 1 , copolymers and/or mixtures thereof.4. The nanocapsules according to claim 3 , wherein the polymer of the coating is selected from the group formed by gelatin claim 3 , albumin claim 3 , soy protein claim 3 , pea protein claim 3 , broad bean protein claim 3 , potato protein claim 3 , wheat protein claim 3 , whey ...

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Номер записи: 38
22-08-2013 дата публикации

SPECIFIC DELIVERY OF AGROCHEMICALS

Номер: US20130217572A1
Автор: De Jonghe Chris, Verheesen Peter
Принадлежит:

Described is the specific delivery of agrochemicals to plants. More specifically, described is a composition having a targeting agent comprising at least one binding domain that specifically binds to a binding site on an intact living plant and an agrochemical or a combination of agrochemicals. Also described is a binding domain that specifically binds the binding site on an intact living plant. More specifically, described are binding domains comprising a peptide sequence that comprises four framework regions and three complementary-determining regions, or any suitable fragment thereof, so that the binding domains are able to bind or retain a carrier onto a plant. Described are binding domains that specifically bind trichomes, stomata, cuticle, lenticels, thorns, spines, root hairs, or wax layer. Described is a method for delivery of agrochemicals to a plant, for improving the deposition of agrochemicals on a plant, and for retaining the agrochemicals on a plant, using targeting agents comprising the binding domains, and to a method for protecting a plant against biotic or abiotic stress or controlling plant growth using the same. Also, described is a method for manufacturing a specifically targeting agrochemical carrier. 1. A process for producing specifically targeting microcapsules , the process comprising:emulsifying into a continuous aqueous phase an organic phase in which a to be encapsulated agrochemical or combination of agrochemicals is dissolved or dispersed to form an emulsion of droplets of the organic phase in the continuous aqueous phase;causing an aqueous suspension of microcapsules with polymer walls having anchor groups at their surface to be formed; andcovalently linking at least one targeting agent to the anchor groups at the microcapsule surface, at a ratio from about 0.01 μg to about 1 μg targeting agent per square centimeter microcapsular surface.2. The process of claim 1 , further comprising:causing polymerization of polyfunctional monomers ...

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Номер записи: 39
22-08-2013 дата публикации

PROCESS FOR MAKING MULTIPARTICULATE GASTRORETENTIVE DOSAGE FORMS

Номер: US20130217777A1
Автор: Kirkorian Joel Sylvain Michel
Принадлежит: Meliatys

The instant invention relates to a process for making inherent low density particles, comprising the steps of (i) providing a powder mixture comprising a swelling agent; (ii) granulating the powder of step (i) with a granulating solution comprising a lipophilic agent into granules and (iii) drying the granules of step (ii). The instant invention further relates to multiparticulate oral gastro-retentive dosage forms comprising the inherent low density particles obtainable by the process. 1. A process for making low density particles , comprising the steps of:(i) providing a powder mixture comprising a swelling agent;(ii) granulating the powder of step (i) with a granulating solution comprising a lipophilic agent into granules;(iii) drying the granules of step (ii).2. The process according to claim 1 , further comprising the step (iv) of compressing the granules of step (iii).3. The process according to claim 1 , further comprising the step (v) of coating the granules resulting from step (ii) or step (iii).4. The process according to claim 1 , wherein the active ingredient is added into the starting powder of step (i) and/or the granulating solution of step (ii) claim 1 , preferably into the starting powder of step (i) and/or is laid on the granules obtained in step (iii).5. The process according to claim 1 , wherein a binder is added with the starting material in step (i) and/or the granulating solution of step (ii) claim 1 , preferably into the starting powder of step (i).6. The process according to claim 1 , wherein the swelling agent is a cellulose derivative having a molecular weight from 4 claim 1 ,000 to 2 claim 1 ,000 claim 1 ,000 claim 1 , hydroxymethylcellulose claim 1 , hydroxyethylcellulose hydroxypropyl methylcellulose claim 1 , superporous hydrogels; polyethylene oxides claim 1 , polyethylenes; polypropylenes; polyvinyl chlorides; polycarbonates; polystyrenes; polyacrylates; carboxyvinyl polymers; polyvinyl alcohols; glucans; scleroglucans; chitosans; ...

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Номер записи: 40
29-08-2013 дата публикации

METHOD FOR PREPARING MICROSPHERES AND MICROSPHERES PRODUCED THEREBY

Номер: US20130224257A1
Автор: Hong Seok Hyun, Hwang Yong Youn, KIM Hong-Kee, Lee Bong-Yong, LEE Kyu Ho, Lee Yoon-Jung, Oh Joon-Gyo, Sah Hong Kee, UM Key-An
Принадлежит:

The present invention relates to a method for preparing microsphere and microspheres produced thereby. The method comprises: mixing a water-insoluble organic solvent with a dispersion solvent; mixing a polymer compound, a drug and a water-insoluble organic solvent to prepare a dispersed phase; mixing the dispersed phase with the dispersion solvent mixed with the water-insoluble organic solvent to prepare an emulsion; and adding a base or an acid to the prepared emulsion. With the method, it is possible to prepare a drug-containing polymeric microsphere cost-effectively and conveniently. 1. A method for preparing a polymeric microsphere , comprising the steps of:(a) mixing a water-insoluble organic solvent with a dispersion solvent;(b) mixing a polymer compound, a drug and a water-insoluble organic solvent so as to prepare a dispersed phase;(c) mixing the dispersed phase of step (b) with the dispersion solvent mixed with the water-insoluble organic solvent of step (a) so as to prepare an O/W (oil-in-water), O/O (oil-in-oil) or W/O/W (water-in oil-in-water) type emulsion; and(d) adding a base or an acid to the emulsion of step (c) so as to remove the water-insoluble organic solvent from the emulsion.2. A method for preparing a polymeric microsphere , comprising the steps of:(a) mixing a water-insoluble organic solvent with a dispersion solvent;(b) mixing a polymer compound, a drug and a water-insoluble organic solvent so as to prepare a dispersed phase;(c) mixing the dispersed phase of step (b) with the dispersion solvent mixed with the water-insoluble organic solvent of step (a) so as to prepare an O/W (oil-in-water), O/O (oil-in-oil) or W/O/W (water-in oil-in-water) type emulsion; and(d) adding a base or an acid to the prepared emulsion of step (c) so as to remove the water-insoluble organic solvent from the emulsion.(e) obtaining the polymeric microsphere prepared of step (d) and re-dispersing the obtained polymeric microsphere in a warmed dispersion solvent.3. The ...

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Номер записи: 41
29-08-2013 дата публикации

MICROCAPSULES

Номер: US20130225717A1
Автор: DYLLICK-BRENZINGER Rainer, Hentze Hans-Peter, Jung Marc Rudolf, Niederberger Dieter, Willax Hans
Принадлежит: BASF SE

The present invention concerns microcapsules comprising a capsule core and a capsule wall, the capsule wall being constructed from 1. Microcapsules comprising a capsule core and a capsule wall , wherein the capsule wall is formed from at least one polymer comprising:{'sub': 1', '24, '(A) 30% to 90% by weight of one or more C-C-alkyl esters of acrylic and/or methacrylic acid, acrylic acid, and/or methacrylic acid and/or maleic acid as monomer I,'}(B) 10% to 70% by weight of a mixture of divinyl and polyvinyl monomers as monomer II, wherein a fraction of the polyvinyl monomers is in the range from 2% to 90% by weight based on the monomers II, and(C) 0% to 30% by weight of one or more additional monomers other than monomers I and II, as monomer III,wherein the weight percent of (A), (B), and (C) is based on the total weight of the monomers, andwherein the capsule core comprises a lipophilic substance which comprises a biocide.2. The microcapsules according to claim 1 , which have an average particle size of 1.5-2.5 μm and 90% of the particles have a particle size ≦4 μm.3. The microcapsules according to claim 1 , wherein the fraction of the polyvinyl monomers is in the range from 5% to 80% by weight based on the sum total of divinyl and polyvinyl monomers.4. The microcapsules according to claim 2 , wherein the fraction of the polyvinyl monomers is in the range from 5% to 80% by weight based on the sum total of divinyl and polyvinyl monomers.5. The microcapsule according to claim 1 , wherein the polyvinyl monomer is at least one monomer selected from the group consisting of trimethylolpropane triacrylate claim 1 , trimethylolpropane trimethacrylate claim 1 , pentaerythritol triallyl ether claim 1 , pentaerythritol tetraallyl ether claim 1 , pentaerythritol triacrylate claim 1 , and pentaerythritol tetraacrylate.6. The microcapsule according to claim 1 , wherein additionally polyelectrolytes having an average molecular weight in the range from 500 g/mol to 10 million g/ ...

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Номер записи: 42
05-09-2013 дата публикации

Process for preparing polyurea microcapsules

Номер: US20130230574A1
Автор: Arnaud Struillou, Claudie Bellouard Drevet, Nicolas Pichon, Sonia GODEFROY
Принадлежит: FIRMENICH SA

The present invention relates to a process for producing perfume-containing microcapsules with a polyurea wall that can be used in home or personal care products, as well as to the microcapsules themselves and consumer products that contain these microcapsules. The process of the invention uses a combination of aromatic and aliphatic polyisocyanates in specific relative concentrations.

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Номер записи: 43
05-09-2013 дата публикации

Self-Assembling Polymer Particle Release System

Номер: US20130231244A1
Автор: JR. Robert S., McGinniss Vincent D., Monson K. David, Risser Steven B., Roshon Melissa S., Spahr Kevin B., Whitmore
Принадлежит: BATTELLE MEMORIAL INSTITUTE

Self-assembly is defined as the ability of an active ingredient (AI), when mixed with a polymer or polymers (solid or liquid state), to form either a complex or a strong attraction with the polymer/polymers, which influences the controlled release of the total system. This AI-polymer interaction or strong attraction can form in the solid state or in solution. The AI-polymer interaction also can form when applied to a filter paper, soil, seeds, or plant vegetation substrates, where the AI and polymer self-assembles into an AI-polymer-substrate matrix or complex that influences how the AI releases from the complex or matrix in a controlled manner. 1. Method for constructing a self-assembling polymeric particle bearing an active ingredient (“AI”) , which comprises the steps of:(a) determining the solubility parameter for an AI, said AI having a user defined characteristic not evidenced by the AI for a user defined application;(b) matching the AI solubility parameter with the solubility parameter of a first polymer for forming an AI/first polymer stable blend;(c) determining a second polymeric interface control agent that assists said AI in said AI/first polymer blend to evince the user defined characteristic for the user defined application, and blending said second polymeric interface control agent with said AI/first polymer blend to form a second blend;(d) if said second blend is not stable in water, adding a water-stabilizing additive to said second blend; and(e) making a water stable blend of said second blend and said water-stabilizing additive, if any;said second blend forming a self-assembled polymeric particle upon deposition of said second blend upon a surface, said self-assembling polymeric particle having a core of said AI with said first polymer, said second polymeric interface control agent, and said water-stabilizing additive, if any, enveloping said AI.2. The method of claim 1 , wherein the AI is combined with solubility parameter matched free radical or ...

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Номер записи: 44
19-09-2013 дата публикации

Micro-encapsulated Chemical Re-application Method

Номер: US20130239429A1
Автор: Marks Thomas I., Vella Judy
Принадлежит:

An application is provided that transfers volatile compounds encapsulated by a variety of methods to achieve a targeted release of those compounds to provide specific functional effects during normal use of the fabrics to which the encapsulated materials are transferred. This application is renewable and is typically performed during normal laundering of targeted fabrics. 1. A method of re-applying an encapsulated compound comprising the steps of:applying a designed blend of encapsulated compound to a substrate as a carrier of the encapsulated compounds, for use as one of a pesticide and aromatherapy; and thendrying a fabric with the substrate in a dryer thereby transferring the compound to the fabric in the dryer in a effective amount to perform a desired effect selected from the group of providing a pesticide and an aromatherapy effect.2. The method of wherein the substrate is a non-woven selected from the group of natural claim 1 , synthetic claim 1 , and regenerated fibers.3. The method of wherein the substrate is selected form the group of woven fabrics claim 1 , foam claim 1 , and sponges.4. The method of wherein the encapsulated compound is applied to the substrate through spraying claim 1 , dipping claim 1 , and other coating.5. The method of wherein the encapsulated compound is one of solvent-based claim 1 , water-based claim 1 , and dry powder-based as applied to the substrate.6. The method of whereby the encapsulated compounds are volatile essential oils and floral essences selected from the group of bergamot oil claim 1 , cedar oil claim 1 , chamomile oil claim 1 , cinnamon oil claim 1 , citronella oil claim 1 , clove oil claim 1 , eucalyptus oil claim 1 , frankincense oil claim 1 , garlic oil claim 1 , geranium oil claim 1 , ginger oil claim 1 , lavender oil claim 1 , lemon oil claim 1 , lemongrass oil claim 1 , lime oil claim 1 , mandarin oil claim 1 , melissa oil claim 1 , mint oil claim 1 , myrrh oil claim 1 , orange oil claim 1 , oregano oil claim 1 ...

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Номер записи: 45
19-09-2013 дата публикации

Anionic lipids and lipid nano-structures and methods of producing and using same

Номер: US20130243688A1
Автор: Pallavi Lagisetty, Vibhudutta Awasthi
Принадлежит: The Board of Regents of the University of Oklahoma

Anionic non-phospholipids, as well as lipid nanostructures formed therefrom, are disclosed herein. Also disclosed are methods of producing and using same.

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Номер записи: 46
19-09-2013 дата публикации

ENCAPSULATED SOLID HYDROPHILIC PARTICLES

Номер: US20130245153A1
Автор: SCHWANTES Todd Arlin
Принадлежит:

A process of forming microcapsules is described. The microcapsule population is formed by providing an anionic or cationic, solid hydrophilic core material; providing an oil continuous phase, the oil continuous phase comprising one or more esters with chain length up to about 18 carbons. Emulsification is achieved by subjecting the mixture to high shear agitation and heating the mixture for a time sufficient to enable acid or amine acrylate or methacrylate and multifunctional acrylate or methacrylate to form a prepolymer which migrates to the anionic or cationic solid hydrophilic material, thereby forming prepolymers adhered to the hydrophilic core materials. Temperature is held or heating continued for a time sufficient to enable the prepolymer to flow onto and coalesce into a continuous film surface coating on the hydrophilic core material. Heating is carried out or light exposure or both for a time and temperature sufficient to cross link the prepolymers. 1. A process of forming a population of microcapsules comprising a solid hydrophilic core material and a wall material at least partially surrounding the core material , the microcapsule population being formed by:providing particles of a solid hydrophilic core material; forming a mixture by:', 'adding an oil soluble or dispersible amine acrylate or methacrylate;', 'adding a multifunctional acrylate or methacrylate monomer or oligomer;', 'adding an acid and an initiator;, 'providing an oil continuous phase which is low boiling and preferably nonflammable, the oil continuous phase comprising one or more hydrocarbons with chain length up to about 18 carbons;'}optionally adding a surfactant;dispersing the mixture by subjecting the mixture to agitation; heating the mixture for a time sufficient to enable the amine acrylate or methacrylate and the multifunctional acrylate or methacrylate to form a cationic prepolymer;dispersing the solid hydrophilic material in the oil continuous phase whereby the cationic prepolymer ...

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Номер записи: 47
26-09-2013 дата публикации

Method of Inducing a Phase Transition of a Bilayer Membrane Vesicle

Номер: US20130251788A1
Автор: Kunishima Munetaka
Принадлежит: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Provided is a bilayer membrane vesicle capable of undergoing a phase transition. The bilayer membrane vesicle includes: (a) a fatty acid salt having 6 to 20 carbon atoms; (b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms; and (c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane. Preferably, this bilayer membrane vesicle further contains (d) a tertiary amine as a component of the membrane. Also provided is a method of inducing a phase transition of a bilayer membrane vesicle, the method including the step of adding a dehydrating condensing agent or a dehydrating condensing agent precursor having the property of accumulating at an interface to the bilayer membrane vesicle. By causing the lipids that form a molecular aggregate to chemically change, it is possible to change the physical property and the morphology of the molecular aggregate and control the timing of phase transitions such as membrane fusion. In the membrane fusion, for example, fusion can occur without leakage of the contents of the bilayer membrane vesicle. 1. A method of inducing a phase transition of a bilayer membrane vesicle , comprising:preparing a bilayer membrane vesicle, in which the bilayer membrane vesicle comprises as components of the membrane:(a) a fatty acid salt having 6 to 20 carbon atoms;(b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms; and(c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane; andadding a dehydrating condensing agent or a dehydrating condensing agent precursor to the bilayer membrane vesicle.2. The method of claim 1 , wherein the (b) alcohol or amine compound is a dihydric alcohol represented by the following formula I:{'br': None, 'sup': '1', 'sub': 2', '2, 'R—NH—CH—CH(OH)—CHOH\u2003\u2003(I)'}{'sup': '1', 'wherein Ris an alkyl group having 6 to 20 carbon atoms, an alkenyl group having 6 to 20 carbon atoms, or an alkynyl ...

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Номер записи: 48
17-10-2013 дата публикации

METHODS FOR PREPARATION OF LIPID-ENCAPSULATED THERAPEUTIC AGENTS

Номер: US20130273146A1
Автор: Cullis Pieter R., Maurer Norbert, Wong Kim F.
Принадлежит:

Fully lipid-encapsulated therapeutic agent particles of a charged therapeutic agent are prepared by combining a lipid composition containing preformed lipid vesicles, a charged therapeutic agent, and a destabilizing agent to form a mixture of preformed vesicles and therapeutic agent in a destabilizing solvent. The destabilizing solvent is effective to destabilize the membrane of the preformed lipid vesicles without disrupting the vesicles. The resulting mixture is incubated for a period of time sufficient to allow the encapsulation of the therapeutic agent within the preformed lipid vesicles. The destabilizing agent is then removed to yield fully lipid-encapsulated therapeutic agent particles. The preformed lipid vesicles comprise a charged lipid which has a charge which is opposite to the charge of the charged therapeutic agent and a modified lipid having a steric barrier moiety for control of aggregation. 2. The method of claim 1 , wherein the charged lipid in the preformed lipid vesicles comprises a cationic lipid and the therapeutic agent is an anionic therapeutic agent.3. The method of claim 2 , wherein the therapeutic agent is a polynucleotide.4. The method of or claim 2 , wherein the cationic lipid is selected from the group consisting ofdioleyl-N,N-dimethylammonium chloride (“DODAC”);N-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium chloride (“DOTMA”);N,N-distearyl-N,N-dimethylammonium bromide (“DDAB”); N-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium chloride (“DOTAP”);3β-(N-(N′,N′-dimethylaminoethane)-carbamoyl)cholesterol (“DC-Chol”);N-(1,2-dimyristyloxyprop-3-yl)-N,N-dimethyl-N-hydroxyethyl ammonium bromide (“DMRIE”);cationic liposomes comprising DOTMA and 1,2-dioleoyl-sn-3-phosphoethanolamine (“DOPE”);cationic liposomes comprising N-(1-(2,3-dioleyloxy)propyl)-N-(2-(sperminecarboxamido)ethyl)-N,N-dimethylammonium trifluoroacetate (“DOSPA”) and DOPE;cationic lipids comprising dioctadecylamidoglycyl carboxyspermine (“DOGS”) in ethanol;N-(2,3-dioleyloxy) ...

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Номер записи: 49
07-11-2013 дата публикации

POLY(METH)ACRYLATE BASED MICROCAPSULES COMPRISING PHEROMONE

Номер: US20130295154A1
Автор: Benlahmar Ouidad, Hennessey Tiffany, Klein Clark D., Schroeder-Grimonpont Tina, Stracke Joseph, Taranta Claude
Принадлежит: BASF SE

The present invention relates to a microcapsule comprising a capsule core, which contains a pheromone, and a capsule wall, which contains in polymerized form 30 to 90% by weight of one or more C-C-alkyl esters of acrylic acid and/or methacrylic acid, acrylic acid, methacrylic acid and/or maleic acid (monomers I), 10 to 70% by weight of one or more difunctional and/or poly-functional monomers (monomers II), and 0 to 40% by weight of one or more other monomers (monomer III), in each case based on the total weight of the monomers. The invention further relates to a process for the preparation of said microcapsules; a method for controlling undesired insect infestation; and a composition for controlling undesired insect infestation comprising a pheromone and ethyl 3-methylbutanoate. 117-. (canceled)18. A microcapsule comprising a capsule core , which contains a pheromone and a water-immiscible organic solvent , and a capsule wall , which contains in polymerized form{'sub': 1', '24, '30 to 90% by weight of one or more C-C-alkyl esters of acrylic acid and/or methacrylic acid, acrylic acid, methacrylic acid and/or maleic acid (monomers I),'}10 to 70% by weight of one or more difunctional and/or polyfunctional monomers (monomers II), and0 to 40% by weight of one or more other monomers (monomer III),in each case based on the total weight of the monomers,wherein the pheromone is present in dissolved form in the capsule core,wherein the capsule core contains an attractant selected from non-food attractants and food attractants, and wherein the non-food attractants are flavors of natural or synthetic origin, or mixtures thereof,wherein the water-immiscible organic solvent has a solubility in water of up to 10 g/l at 20° C.,wherein the difunctional monomers are divinylmonomers selected from diesters of diols with acrylic acid or methacrylic acid, and diallyl and divinyl ethers of diols, andwherein the polyfunctional monomers are polyvinylmonomers selected from polyesters of ...

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Номер записи: 50
14-11-2013 дата публикации

METHOD FOR ENCAPSULATING PARTICLES

Номер: US20130302429A1
Автор: Khung Yit Lung, Lee Wei Li, Loo Say Chye Joachim
Принадлежит: NANYANG TECHNOLOGICAL UNIVERSITY

The present invention relates to a method for encapsulating particles of a water-insoluble material within a capsule of a water-insoluble polymer, comprising (a) dispersing particles of the water-insoluble material or a solution containing the water-insoluble material in a first aqueous phase containing a first surfactant to obtain a first dispersion; (b) collecting the particles of the water-insoluble material coated with the first surfactant; (c) washing the collected particles; (d) adding the washed surfactant-coated water-insoluble material particles to a polymer solution containing the water-insoluble polymer of the capsule to obtain a polymer mixture; and (e) dispersing the polymer mixture in a second aqueous phase containing a second surfactant to obtain a second dispersion comprising the particles of the water-insoluble material encapsulated within the capsule of the water-insoluble polymer. 2. (canceled)3. (canceled)4. The method of claim 1 , wherein the particles of the water-insoluble material or the solution of the water-insoluble material as used in step (a) further comprises a marker substance and/or therapeutic agent.5. (canceled)6. (canceled)7. The method of claim 4 , wherein the solution of the water-insoluble material is formed by:dissolving the water-insoluble material in a first volume of a suitable solvent and combining the solution with a second volume of a suitable solvent containing the marker substance or therapeutic agent.8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. The method of claim 1 , wherein particles of the water-insoluble material further comprise particles of a further water-insoluble material.13. The method of claim 12 , wherein the further water-insoluble material comprises or consists of at least one polymer.14. The method of claim 12 , wherein the further water-insoluble material comprises or consists of iron oxide or titanium dioxide.15. The method of claim 1 , wherein prior to collecting the particles in step (b) ...

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Номер записи: 51
21-11-2013 дата публикации

LONG-LASTING CONTROLLED-RELEASE LIPOSOME COMPOSITION AND METHOD FOR PRODUCING SAME

Номер: US20130309297A1
Автор: Nozawa Shigenori, Otomo Naoki, YAMASHITA Keiko
Принадлежит: TERUMO KABUSHIKI KAISHA

A liposome composition, which is obtained by mixing a water-miscible organic solution in which a phospholipid and cholesterol are contained in a total concentration of 100 to 200 w/v % in a water-miscible organic solvent with a first aqueous phase solution in an amount of 3/1 to 12/1 in terms of volume ratio to the water-miscible organic solution, thereby obtaining an emulsion in which the total concentration of the phospholipid and cholesterol in the resulting mixed phase is 15 to 50 w/v %, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution, wherein an ion gradient is formed between an aqueous phase in an internal region of a liposome membrane, including the first aqueous phase solution, and an aqueous phase in an external region of the liposome membrane, including the second aqueous phase solution, and a drug can be introduced in a high encapsulation amount. 1. A liposome composition obtained by mixing a water-miscible organic solution in which a phospholipid and cholesterol are contained in a total concentration of 100 to 200 w/v % in a water-miscible organic solvent with a first aqueous phase solution in an amount of 3/1 to 12/1 in terms of volume ratio to the water-miscible organic solution , thereby obtaining an emulsion in which the total concentration of the phospholipid and cholesterol in the resulting mixed phase is 15 to 50 w/v % , followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution , wherein an ion gradient is formed between an aqueous phase in an internal region of a liposome membrane , the internal-region aqueous phase including the first aqueous phase solution , and an aqueous phase in an external region of the liposome membrane , the external-region aqueous phase including the second aqueous phase solution.2. The liposome composition according to claim 1 , wherein the ion gradient is pH proton gradient claim 1 , and the liposome composition has a pH ...

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Номер записи: 52
12-12-2013 дата публикации

Method of Making Small Liposomes

Номер: US20130330398A1
Автор: DUPUIT Robert A., REILLEY William J.
Принадлежит:

Liposomes of constrained particle size are prepared by substantially continuously mixing substantially continuously flowing streams of water, and of an organic solvent contain lipid(s) capable of forming liposomes, and cooling the mixture so liposomes form, the ratio of the flow rate of the stream of water to the flow rate of the stream of organic solvent, and the rate of cooling of said mixture, being controlled so as to obtain a preparation of liposomes such that at least about 90% of the liposomes are of a particle size less than about 200 nm. 125-. (canceled)26. A composition comprising liposomes of constrained particle size wherein at least about 90% of the liposomes are of a particle size less than about 200 nm and wherein the liposomes further comprise an adjuvant.27. A composition according to claim 26 , wherein the liposomes comprise phospholipids selected from the group consisting of dipalmitoylphosphatidylcholine (DPPC) claim 26 , phosphatidylcholine (PC; lecithin) claim 26 , phosphatidic acid (PA) claim 26 , phosphatidylglycerol (PG) claim 26 , phosphatidylethanolamine (PE) claim 26 , phosphatidylserine (PS). Other suitable phospholipids further include distearoylphosphatidylcholine (DSPC) claim 26 , dimyristoylphosphatidylcholine (DMPC) claim 26 , dipalmitoylphosphatidyglycerol (DPPG) claim 26 , distearoylphosphatidyglycerol (DSPG) claim 26 , dimyristoylphosphatidylglycerol (DMPG) claim 26 , dipalmitoylphosphatidic acid (DPPA); dimyristoylphosphatidic acid (DMPA) claim 26 , distearoylphosphatidic acid (DSPA) claim 26 , dipalmitoylphosphatidylserine (DPPS) claim 26 , dimyristoylphosphatidylserine (DMPS) claim 26 , distearoylphosphatidylserine (DSPS) claim 26 , dipalmitoylphosphatidyethanolamine (DPPE) claim 26 , dimyristoylphosphatidylethanolamine (DMPE) and distearoylphosphatidylethanolamine (DSPE).28. A composition according to claim 26 , wherein the liposomes comprise dipalmitoylphosphatidylcholine (DPPC).29. A composition according to claim 26 , ...

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Номер записи: 53
26-12-2013 дата публикации

SUSTAINED-RELEASE LIPOSOMAL ANESTHETIC COMPOSITIONS

Номер: US20130344132A1
Автор: Kim Sinil, Kim Taehee, Murdande Sharad
Принадлежит: PACIRA PHARMACEUTICALS, INC.

The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia. 1. A pharmaceutical composition comprising: at least one type of amphipathic lipid, and', 'at least one type of neutral lipid; and, 'a) a multivesicular liposome comprising'} 'polyhydroxy carboxylate salts and di- or tri-protic mineral salts of amide-type anesthetics,', 'b) an aqueous phase comprising'}wherein the aqueous phase is encapsulated within the multi vesicular liposome.2. The pharmaceutical composition of claim 1 , wherein the aqueous phase further comprises hydrochloric acid.3. The pharmaceutical composition of claim 1 , wherein the amphipathic lipid is provided in admixture with cholesterol claim 1 , plant sterols claim 1 , or combinations thereof.4. The pharmaceutical composition of claim 1 , wherein the di- or tri-protic mineral salts of the amide-type anesthetics are selected from the group consisting of sulfates claim 1 , phosphates claim 1 , and combinations thereof.5. The pharmaceutical composition of claim 1 , wherein the polyhydroxy carboxylate salts of the amide-type anesthetics are selected from the group consisting of glucuronate claim 1 , gluconate claim 1 , tartarate claim 1 , and combinations thereof.6. The pharmaceutical composition of claim 1 , wherein the amphipathic lipid is selected from the group consisting of phosphatidylcholines ...

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Номер записи: 54
09-01-2014 дата публикации

SERIES OF CAPSULES COMPRISING AT LEAST ONE DROP OF INTERNAL PHASE IN A DROP OF INTERMEDIATE PHASE AND MANUFACTURING METHOD THEREOF

Номер: US20140011033A1
Автор: Carreras Enric Santanach, Pafumi Yan
Принадлежит: CAPSUM

Each capsule comprises a liquid core () and a gelled shell () comprising a gelled polyelectrolyte completely encapsulating the liquid core () at the periphery thereof. The gelled shell () is suitable for retaining the liquid core () when the capsule () is immersed in a gas. 1. A series of capsules , each capsule being of the type comprising:a liquid core,a gelled shell comprising a gelled polyelectrolyte completely encapsulating the liquid core at the periphery thereof, the gelled shell being suitable for retaining the liquid core when the capsule is immersed in a gas;wherein the liquid core comprises an intermediate drop of an intermediate phase, the intermediate phase being placed in contact with the gelled shell, and at least one internal drop of an internal phase placed in the intermediate drop, the ratio of the volume of the core to the volume of the gelled shell being greater than 2.2. A series of capsules according to claim 1 , wherein the ratio of the volume of the core to the volume of the gelled shell is between 5 and 10.3. A series of capsules according to claim 1 , wherein the thickness of the gelled shell is less than 500 microns.4. A series of capsules according to claim 1 , wherein each internal drop is placed completely away from the gelled shell claim 1 , the intermediate phase being interposed between the or each internal drop and the gelled shell.5. A series of capsules according to claim 1 , wherein the or each internal drop has a volume greater than 0.5% of the volume of the core.6. A series of capsules according to claim 1 , wherein the maximum transverse dimension of the or each internal drop is greater than 150 micrometres.7. A series of capsules according to claim 1 , wherein each capsule comprises at least two internal macroscopic drops disposed in the intermediate drop claim 1 , each internal macroscopic drop comprising an internal phase.8. A series of capsules according to claim 7 , wherein each capsule comprises at least two internal ...

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Номер записи: 55
06-02-2014 дата публикации

NOVEL NANOPARTICLES

Номер: US20140037741A1
Автор: ARMES Steven, YUAN Jian-Jun
Принадлежит: DSM IP ASSETS B.V.

Methods for the preparation of polymer-templated core-shell nanoparticles include the steps of (a) preparing a cationic polymeric core material comprising polymeric micelles, and (b) coating the core material with a silica-comprising shell by depositing the shell onto the polymeric micelles from at least one silica precursor to form the core-shell nanoparticles. Compositions which include the core-shell nanoparticles are adapted to facilitate controlled delivery of at least one active agent into a system in response to controlled changes in the pH of the system. 1. A method for the preparation of polymer-templated core-shell nanoparticles comprising the steps of:(a) preparing a cationic polymeric core material comprising polymeric micelles employing a quaternized polymer; and(b) coating said core material with a shell comprising silica by depositing the shell onto the polymeric micelles from at least one silica precursor to form the core-shell nanoparticles.2. The method as in claim 1 , wherein step (a) is practiced by preparing the polymeric core material by group transfer polymerisation or controlled radical polymerisation.3. The method of claim 1 , wherein the polymeric micelles comprise copolymeric micelles.4. The method of claim 3 , wherein the copolymeric micelles comprise a diblock copolymer micelle.5. The method of claim 4 , wherein said diblock copolymer micelle has a core comprising at least one block of a first polymer and a corona comprising at least one block of a second polymer wherein said second polymer is different to said first polymer.6. The method of or claim 4 , wherein said copolymer comprises a first polymer and a second polymer which both comprise amino-group comprising (alk)acrylate monomer units.7. The method of claim 6 , wherein said (alk)acrylate units comprise acrylate units.8. The method of claim 3 , wherein the copolymeric micelles are formed of a copolymer which comprises poly[2-(diisopropylamino)ethyl methacrylate)-block-2-( ...

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Номер записи: 56
13-02-2014 дата публикации

LIPOSOMAL APPARATUS AND MANUFACTURING METHODS

Номер: US20140044772A1
Автор: Giesbrecht Cory, Jeffs Lioyd, MacLachlan Ian, PALMER LORNE R.
Принадлежит: Protiva Biotherapeutics, Inc.

The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol. 156-. (canceled)57. A process for producing a lipid vesicle encapsulating one or more therapeutic agents within the lipid vesicle , said process comprising:providing an aqueous solution in a first reservoir;providing an organic lipid solution in a second reservoir, wherein the lipids present in said organic lipid solution are solubilized in a lower alkanol at a concentration of about 75% v/v to 100% v/v, and wherein said aqueous solution and/or said organic lipid solution comprises one or more therapeutic agents; andmixing said organic lipid solution with said aqueous solution by introducing said organic lipid solution and said aqueous solution into a mixing environment at about equal flow rates;wherein said mixing instantaneously produces a lipid vesicle encapsulating said one or more therapeutic agents within the lipid vesicle by diluting said lower alkanol to a concentration of between 45% v/v to about 60% v/v; andwherein the mixing environment includes a mixing chamber, wherein said aqueous solution and said organic lipid solution are introduced into the mixing chamber at an angle of between about 27° and about 180° relative to each other and mixed within the mixing chamber.58. The process of claim 57 , further comprising diluting said lipid vesicle with a buffer solution wherein said lipid vesicle undergoes a continuous stepwise dilution to further stabilize the lipid vesicle.59. The process of claim 57 , wherein said one or more therapeutic agents is selected from the group consisting of a nucleic acid claim 57 , a hydrophilic active agent claim 57 , a hydrophobic active agent claim 57 , a small ...

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Номер записи: 57
13-02-2014 дата публикации

Liposome Composition

Номер: US20140044777A1
Автор: Hyodo Kenji, Ishihara Hiroshi, Kikuchi Hiroshi
Принадлежит: Eisai R&D Management Co., Ltd.

The present invention provides a novel liposome composition containing eribulin or its pharmacologically permissible salt, and its method of manufacture. 139-. (canceled)40. A pharmaceutical composition comprising:an amount of eribulin and/or a pharmaceutically acceptable salt thereof, said amount being contained in the internal phase of a liposome;{'sub': '4', 'sup': '+', 'wherein the internal phase of said liposome comprises citric acid and/or a citrate salt and at least one ammonium (NH) salt.'}41. The pharmaceutical composition according to claim 40 , wherein said at least one said ammonium (NH) salt is chosen from ammonium sulfate claim 40 , ammonium citrate claim 40 , and ammonium tartrate.42. The pharmaceutical composition according to claim 40 , wherein the internal phase further comprises at least one pH adjuster.43. The pharmaceutical composition according to claim 42 , wherein said at least one pH adjuster is chosen from a base.44. A method for preparing a pharmaceutical composition comprising eribulin and/or a pharmaceutically acceptable salt thereof comprising:{'sub': '4', 'sup': '+', '(a) preparing a liposome, wherein the internal phase of said liposome comprises citric acid and/or a citrate salt and at least one ammonium (NH) salt;'}(b) preparing a solution comprising eribulin and/or a pharmaceutically acceptable salt thereof; and(c) combining the liposome prepared in (a) with the solution prepared in (b) to obtain a liposome composition comprising eribulin and/or a pharmaceutically acceptable salt thereof entrapped in the internal phase of said liposome composition;wherein the entrapment achieved in (c) in said internal phase of said liposome composition results in an entrapment ratio of at least 60 to 100% of said eribulin and/or said pharmaceutically acceptable salt thereof.45. The method for preparing a pharmaceutical composition according to claim 44 , further comprising:(d) adjusting the pH of the external phase of said liposome to a value ...

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Номер записи: 58
27-02-2014 дата публикации

EFFICIENT METHOD FOR LOADING AMPHOTERIC LIPOSOMES WITH NUCLEIC ACID ACTIVE SUBSTANCES

Номер: US20140056970A1
Автор: Endert Gerold, Herzog Natalie, Muller Claudia, Panzner Steffen, Rauchhaus Una
Принадлежит: MARINA BIOTECH, INC.

A method for preparing amphoteric liposomes loaded with a polyanionic active agent as cargo, characterised by admixing an aqueous solution of said polyanionic active agent and an alcoholic solution of one or more amphiphiles and buffering said admixture to an acidic pH, said one or more amphiphiles being susceptible of forming amphoteric liposomes at said acidic pH, thereby to form such amphoteric liposomes in suspension encapsulating said active agent under conditions such that said liposomes form aggregates, and thereafter treating said suspension to dissociate said aggregates. Also disclosed are nucleic acid loaded amphoteric liposomes produced in accordance with the method, wherein said nucleic acids are oligonucleotides and said liposomes are multilamellar. 1. A method for preparing amphoteric liposomes loaded with a polyanionic active agent as cargo , characterised by admixing an aqueous solution of said polyanionic active agent and an alcoholic solution of one or more amphiphiles and buffering said admixture to an acidic pH , said one or more amphiphiles being susceptible of forming amphoteric liposomes at said acidic pH , thereby to form such amphoteric liposomes in suspension encapsulating said active agent under conditions such that said liposomes form aggregates , and thereafter treating said suspension to dissociate said aggregates.2. A method as claimed in claim 1 , wherein said acidic pH is at least one unit lower than the isoelectric point of said one or more of amphiphiles.3. A method as claimed in or claim 1 , wherein said alcoholic solution is buffered to an acidic pH using a buffer selected from acetate buffers claim 1 , formiate buffers claim 1 , glycine buffers claim 1 , maleic acid buffers claim 1 , phosphate buffers and citrate buffers or an acid selected from HCl claim 1 , acetic acid claim 1 , formic acid claim 1 , maleic acid claim 1 , sulfonic acid claim 1 , phosphoric acid and citric acid.4. A method as claimed in claim 1 , or claim 1 , ...

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Номер записи: 59
06-03-2014 дата публикации

Polymersomes, liposomes, and other species associated with fluidic droplets

Номер: US20140065234A1
Автор: Daeyeon Lee, David A. Weitz, Ho Cheung Shum, Insun Yoon, Jin-woong Kim
Принадлежит: Harvard College

The present invention relates generally to vesicles such as liposomes, colloidosomes, and polymersomes, as well as techniques for making and using such vesicles. In some cases, the vesicles may be at least partially biocompatible and/or biodegradable. The vesicles may be formed, according to one aspect, by forming a multiple emulsion comprising a first droplet surrounded by a second droplet, which in turn is surrounded by a third fluid, where the second droplet comprises lipids and/or polymers, and removing fluid from the second droplet, e.g., through evaporation or diffusion, until a vesicle is formed. In certain aspects, the size of the vesicle may be controlled, e.g., through osmolarity, and in certain embodiments, the vesicle may be ruptured through a change in osmolarity. In some cases, the vesicle may contain other species, such as fluorescent molecules, microparticles, pharmaceutical agents, etc., which may be released upon rupture. Yet other aspects of the invention are generally directed to methods of making such vesicles, kits involving such vesicles, or the like.

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Номер записи: 60
13-03-2014 дата публикации

Method for preparing microparticles with reduced initial burst and microparticles prepared thereby

Номер: US20140072531A1
Автор: Bong-Yong Lee, Hong Kee Kim, Joon-Gyo Oh, Kyu Ho Lee
Принадлежит: SK Chemicals Co Ltd

A method for preparing polymer microparticles with a reduced initial burst, and the polymer microparticles prepared thereby, the method including: contacting polymer microparticles with an alcohol aqueous solution, the polymer microparticles prepared thereby, and use for drug delivery of the polymer microparticles.

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Номер записи: 61
20-03-2014 дата публикации

CEFDINIR AND CEFIXIME FORMULATIONS AND USES THEREOF

Номер: US20140079647A1
Автор: Bilgic Mahmut
Принадлежит:

The invention features pharmaceutically acceptable salts of cefdinir, including primary, secondary, and tertiary amine salts of cefdinir, and preparation methods, and pharmaceutical compositions including cefdinir. The invention also features water dispersible pharmaceutical dosage forms including cefdinir as active agent and methods for preparing the dosages. The invention also features tablet forms of cefixime characterized in that the tablets are in effervescent form. The invention also features the process for preparing effervescent tablet forms with cefdinir as active agents and pharmaceutical formulations obtained by the process. 2. The salt according to claim 1 , wherein A is selected from the group consisting of: ethanolamine claim 1 , 1-deoxy-1-methylamino-sorbitol claim 1 , isopropanolamine claim 1 , 1-deoxy-1-methylamino-D-glucitol-(2S claim 1 ,4R)-4-Hydroxy proline claim 1 , tris(hydroxymethyl)aminomethane claim 1 , N-(Tri(hydroxymethyl)methyl)glycine claim 1 , thiamine claim 1 , 2-methyl-aminophenol claim 1 , and N claim 1 ,N-Bis(2-hydroxyethyl)glycine.3. The salt according to claim 1 , wherein said salt is used in a solid pharmaceutical dosage form; wherein said dosage form is suitable for oral claim 1 , buccal claim 1 , or sublingual application; and wherein said dosage form is film coated tablets claim 1 , extended release tablets claim 1 , modified release tablets claim 1 , chewable tablets claim 1 , effervescent tablets claim 1 , effervescent granules claim 1 , suspensions claim 1 , water dispersible tablets claim 1 , or water dispersible granules.4. A process for preparing the salt according to claim 1 , comprising the steps of:a) dissolving cefdinir and an organic amine comprising more than one hydroxy group in a suitable solvent and stirring at a temperature range of 0-100° C.,b) separating the product that precipitates upon cooling of the reaction mixture, and purifying the product.5. The process according to claim 4 , wherein the amine ...

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Номер записи: 62
20-03-2014 дата публикации

ENCAPSULATING LIPOSOMES

Номер: US20140079773A1
Автор: Franklin Rebekah Kay, Heath Timothy D., Kalkhof Natasha, Krugner-Higby Lisa Ann, Smith Lesley J., Tu Sheng
Принадлежит:

Provided herein is technology relating to liposomes and particularly, but not exclusively, to compositions of liposomes encapsulating a biologically active agent, methods of preparing liposomes encapsulating a biologically active agent, and uses of liposomes encapsulating a biologically active agent to treat a subject. 1. A composition comprising liposomes , sulfate ions , and hydrogen ions , wherein the concentration of the hydrogen ions inside the liposomes is greater than the concentration of the hydrogen ions outside the liposomes.2. The composition of comprising sulfuric acid.3. The composition of claim 1 , wherein the interior of said liposomes has a pH of at least 3 pH units lower than the exterior of said liposomes.4. The composition of comprising a bioactive agent in the interior of the liposomes.5. The composition of wherein said bioactive agent is an analgesic.6. The composition of wherein said bioactive agent is an opioid.7. The composition of wherein said bioactive agent is selected from the group consisting of hydromorphone claim 4 , chloroquine claim 4 , and buprenorphine.8. The composition of wherein said bioactive agent is an antibiotic.9. The composition of claim 8 , wherein said antibiotic is doxycycline.10. The composition of wherein the bioactive agent is selected from the group consisting of an antitumor agent claim 4 , an anaesthetic claim 4 , an analgesic claim 4 , an antimicrobial agent claim 4 , a hormone claim 4 , an antiasthmatic agent claim 4 , a cardiac glycoside claim 4 , an antihypertensive claim 4 , a vaccine claim 4 , an antiarrhythmic claim 4 , an immunomodulator claim 4 , a steroid claim 4 , a monoclonal antibody claim 4 , a neurotransmitter claim 4 , a radionuclide claim 4 , a radio contrast agent claim 4 , a nucleic acid claim 4 , a protein claim 4 , a herbicide claim 4 , a pesticide claim 4 , and suitable combinations thereof.11. The composition of comprising an aqueous buffer and a base outside the liposomes.12. The ...

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Номер записи: 63
03-04-2014 дата публикации

Multilayer Biodegradable Microparticles for Sustained Release of Therapeutic Agents

Номер: US20140093552A1
Автор: Betty Norman, Jennings Robert, Malavia Nikita, Reddy Laxma, Rhodes Chris
Принадлежит: SKS Ocular, LLC

Microparticles are prepared by a method that includes: (a) forming a layer comprising a first polymer on a solid surface by depositing a first composition one or more times on the solid surface, wherein the first composition comprises the first polymer and a first solvent, and evaporating the first solvent in the first composition; (b) forming one or more layers comprising a second polymer and a therapeutic agent by depositing a second composition on all or part of the layer formed in step (a), wherein the second composition comprises the second polymer, the therapeutic agent, and a second solvent; and evaporating the second solvent in the second composition; and (c) forming an additional layer comprising a third polymer by depositing a third composition one or more times on a previously formed layer, wherein the third composition comprises the third polymer and a third solvent; and evaporating the third solvent in the third composition. 1. A method for preparing a multilayer microparticle , the method comprising(a) forming a layer comprising a first polymer on a solid surface by depositing a first composition one or more times on the solid surface, wherein the first composition comprises the first polymer and a first solvent, and evaporating the first solvent in the deposited first composition;(b) forming a layer comprising a second polymer and a therapeutic agent by depositing a second composition on all or part of the layer formed in step (a), wherein the second composition comprises the second polymer, the therapeutic agent, and a second solvent; and evaporating the second solvent in the deposited second composition; and(c) forming an additional layer comprising a third polymer by depositing a third composition one or more times on a previously formed layer, wherein the third composition comprises the third polymer and a third solvent; and evaporating the third solvent in the deposited third composition.2. The method of claim 1 , wherein the first and the third ...

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Номер записи: 64
03-04-2014 дата публикации

METHOD FOR THE DELIVERY OF MOLECULES LYOPHILIZED ONTO MICROPARTICLES TO PLANT TISSUES

Номер: US20140096284A1
Автор: Martin-Ortigosa Susana, Wang Kan
Принадлежит:

The invention provides particles and methods to deliver freeze- or air-dried molecules to cells. 1. A plurality of particles for biolistics of about 0.3 μm to about 1.2 μm in diameter having a freeze-dried or air-dried coating of at least one isolated molecule.2. The plurality of particles of wherein the at least one the isolated molecule includes isolated protein.3. The plurality of particles of wherein the isolated molecule includes isolated nucleic acid and isolated protein.4. The plurality of particles of wherein the isolated molecule includes a drug.5. A method to deliver particles for biolistic delivery of at least one molecule comprising:a) providing a substrate having a solution with a mixture of a plurality of particles and at least one isolated molecule;b) freeze-drying or air-drying the solution in or on the substrate to provide a preparation of particles coated with the at least one molecule; andc) biolistically delivering the plurality to eukaryotic cells in an amount effective to deliver the at least one molecule into the cells, wherein if the cells are not plant cells, the particles are about 0.3 μm to about 1.2 μm in diameter.6. The method of wherein the particles are about 0.3 μm to about 1.2 μm in diameter.7. The method of wherein the molecule is not isolated ribonucleic acid.8. The method of wherein the cells are plant cells.9. The method of wherein the at least one molecule is a protein or a peptide.10. The method of wherein the protein is a recombinase claim 9 , an endonuclease or an enzyme that otherwise modifies nucleic acid.11. The method of wherein the molecule is a DNA ligase claim 10 , polymerase claim 10 , restriction enzyme claim 10 , recombinase claim 10 , such as Cre claim 10 , FLP claim 10 , R or Gin claim 10 , or a nuclease such as a zinc finger nuclease or a transcription activator effector nuclease.12. The method of wherein the particles are coated with isolated nucleic acid and isolated protein.13. The method of wherein the cells ...

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Номер записи: 65
06-01-2022 дата публикации

Method of encapsulating active ingredients in liposomes

Номер: US20220000781A9
Автор: Bárbara Santos de Miranda, Gero Leneweit
Принадлежит: ABNOBA GmbH

A method for encapsulating active ingredients in liposomes having an active ingredient solution encapsulated with a bilayer composed of two monomolecular layers of amphiphilic compounds comprises:(a) providing the active ingredient solution;(b) providing an emulsion by emulsifying the active ingredient solution in a first liquid in the presence of the amphiphilic compound;(c) providing a liquid phase;(d) contacting the emulsion with the liquid phase to form a phase boundary; and(e) centrifuging the emulsion and the liquid phase that are in contact with one another via the phase boundary, wherein, on passage of the phase boundary, the amphiphilic compound enriched there is added onto the monomolecular inner layer to form a monomolecular outer layer, in order to create the bilayer.The first liquid of the emulsion is chosen such that the solubility of the amphiphilic compound in the first liquid is not more than 1×10−4 mol/l.

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Номер записи: 66
07-01-2016 дата публикации

CURCUMIN SOLID LIPID PARTICLES AND METHODS FOR THEIR PREPARATION AND USE

Номер: US20160000714A1
Автор: Diorio Christopher, Lokhnauth John
Принадлежит: Capsugel Belgium NV

Solid lipid particles comprising a lipid hydrophobic matrix and from about 5 wt. % to about 30 wt. % of curcumin, and methods of making and treatment thereof. 1. Solid lipid particles comprising: a lipid hydrophobic matrix; and from about 5 wt. % to about 30 wt. % of curcumin , wherein said lipid hydrophobic matrix is substantially free of water and wherein said solid lipid particles have an average particle size diameter ranging from 100 μm to 1500 μm.2. The solid lipid particles according to claim 1 , wherein the lipid hydrophobic matrix has a melting point ranging from about 15° C. to about 85° C.3. The solid lipid particles according to claim 1 , wherein the lipid hydrophobic matrix has a melting point ranging from about 30° C. to about 45° C.4. The solid lipid particles according to claim 1 , wherein the lipid hydrophobic matrix optionally contains at least one surfactant.5. The solid lipid particles according to claim 1 , wherein the curcumin has an average particle size diameter ranging from about 0.1 μm to about 10 μm.6. (canceled)7. The solid lipid particles according to claim 1 , wherein the solid lipid particles have a substantially spherical shape.8. The solid lipid particles according to claim 1 , wherein the lipid hydrophobic matrix comprises at least one of:{'sub': 6', '40, 'a mixture of monoglycerides, diglycerides, and triglycerides having a carbon number ranging from Cto C,'}{'sub': 6', '12, 'esters of fatty acids having a carbon number ranging from Cto Cwith ethylene glycol or propylene glycol;'}a mixture of triglyceridies having medium chain length; or{'sub': 18', '24, 'a mixture of glycerides having a carbon number ranging from Cto C.'}9. The solid lipid particles according to claim 1 , wherein the lipid hydrophobic matrix comprises a mixture of a wax and at least one non-neutralized fatty acid.10. A process for preparing solid lipid particles according to claim 1 , wherein the process comprises:dispersing a lipid phase having a melting point ...

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Номер записи: 67
04-01-2018 дата публикации

NOVEL SPRAY NOZZLE AND PROCESS FOR MAKING NANOPARTICLES

Номер: US20180000738A1
Автор: "Prudhomme Robert K.", Beyerinck Ronald Arthur, Friesen Dwayne Thomas, Goodwin Aaron Keith, Pansare Vikram J., Vodak David Thomas
Принадлежит: Bend Research, Inc.

Methods for making particulate material include providing a first solution comprising one or more solvents and an active agent, providing a second solution comprising an antisolvent, mixing the first solution with the second solution to form a mixture, atomizing the mixture with a gas to produce droplets, and drying the droplets by directing the droplets into a chamber for removal of the solvent and the antisolvent to produce solid particles. Various apparatuses for producing particulate material in this manner are also provided. 1. A method for making particulate material comprising the steps of:providing a first solution comprising one or more solvents and active agents;providing a second solution comprising an antisolvent, wherein the first solution and/or the second solution further comprises a matrix material;mixing the first solution with the second solution, to form a mixture;atomizing the mixture with a gas to produce droplets;drying the droplets by directing the droplets into a chamber for removal of the solvent and the antisolvent, to produce solid particles;{'b': '3', 'wherein the atomizing step occurs substantially immediately after the mixing step and is followed by the drying step in a continuous mode, and wherein the mixing step starts at a dedicated position of a spray-drying nozzle .'}2. The method of claim 1 , wherein the atomizing step occurs less than or equal to 500 ms after the mixing step.3. The method of claim 1 , wherein the mixing and the atomizing steps occur at two consecutive positions of the spray-drying nozzle.4. The method of claim 1 , wherein the particles comprise distinct active-rich and active poor domains.5. The method of claim 1 , wherein the solvent consists of an organic solvent.6. The method of claim 1 , wherein the matrix material is crystalline claim 1 , amorphous claim 1 , or semi-crystalline.7. The method of claim 6 , wherein the matrix material has a molecular weight of less than 5000 Daltons.8. The method of claim 1 , ...

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Номер записи: 68
02-01-2020 дата публикации

OXIDIZED CELLULOSE MICROSPHERES

Номер: US20200000727A1
Автор: Blaskovich Phillip, OHRI RACHIT, PHAM LAN
Принадлежит:

A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres. 120-. (canceled)21. A composition comprising:a first microsphere including a biodegradable polymer; andat least one second microsphere encapsulated in the first microsphere, wherein the at least one second microsphere includes an oxidized cellulose and at least one bioactive agent.22. The composition according to claim 21 , further comprising:at least one third microsphere encapsulated in the second microsphere, the at least one third microsphere including the biodegradable polymer.23. The composition according to claim 22 , wherein the biodegradable polymer is an aliphatic polyester.24. The composition according to claim 23 , wherein the aliphatic polyester is selected from the group consisting of polylactide claim 23 , polylactide-co-glycolide claim 23 , polylactide-polycaprolactone claim 23 , and combinations thereof.25. The composition according to claim 21 , further comprising at least one additional bioactive agent.26. The composition according to claim 25 , wherein the at least one additional bioactive agent is selected from the group consisting of a hydrophilic bioactive agent claim 25 , a protein therapeutic claim 25 , a biologic claim 25 , and combinations thereof.27. A composition comprising:a plurality of first microspheres formed from a biodegradable polymer; anda plurality of second microspheres encapsulated in at least a portion of the plurality of first microspheres, wherein the plurality of second microspheres are formed from an oxidized cellulose and ...

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Номер записи: 69
02-01-2020 дата публикации

ERYTHRITOL GRANULES AND METHOD FOR PRODUCING SAME, METHOD FOR PRODUCING TABLETS USING SAME, AND TABLETS

Номер: US20200000729A1
Автор: KIMURA Yuki, MINODA Kanako, TOCHIO Takumi, YAMAMOTO Hiromitsu
Принадлежит:

[Problem] 1. Erythritol granules comprising hydroxypropyl cellulose or hydroxypropyl methylcellulose , the granules having a property that when a sample obtained by adding 1.6 mg of magnesium stearate to 160 mg of the erythritol granules is filled in a mortar having a diameter of 8 mm and compressed at a compression rate of 10 mm/min and a pressure of 0 to 100 MPa , an average yield pressure in the range of 30 to 100 MPa is less than 2941 MPa.2. Erythritol granules comprising more than 1.48% by mass and less than 15.25% by mass of hydroxypropyl cellulose or more than 1.48% by mass and less than 10.71% by mass of hydroxypropyl methylcellulose.3. The erythritol granules according to claim 1 , for producing tablets by a dry direct tableting method.4. The erythritol granules according to claim 1 , having a property that when tablets each having a diameter of 8 mm and weighing 200 mg per tablet are formed by adding 1 part by weight of magnesium stearate to 100 parts by weight of the erythritol granules and then tableting the mixture by a dry direct tableting method at a tableting pressure of 5.0 to 6.0 kN claim 1 , a hardness of each of the tablets is not less than 3.5 kgf.5. A method for producing erythritol granules claim 1 , comprising a granulation step of spraying a spray liquid comprising hydroxypropyl cellulose and/or hydroxypropyl methylcellulose to erythritol powder while fluidizing or stirring the erythritol powder claim 1 , and then drying.6. The method for producing erythritol granules according to claim 5 , wherein the granulation step is carried out by a fluidized bed granulation method.7. The method for producing erythritol granules according to claim 5 , wherein in the spray liquid claim 5 , a concentration of the hydroxypropyl cellulose is more than 2.5% by mass and less than 30% by mass claim 5 , or a concentration of the hydroxypropyl methylcellulose is more than 2.5% by mass and less than 20% by mass.8. The method for producing erythritol granules ...

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Номер записи: 70
05-01-2017 дата публикации

RECEPTOR-TARGETED NANOPARTICLES FOR ENHANCED TRANSCYTOSIS MEDIATED DRUG DELIVERY

Номер: US20170000899A1
Автор: Alexis Frank, Blumberg Richard S., Farokhzad Omid C., Langer Robert S., Pridgen Eric M.
Принадлежит:

Receptor-targeted nanoparticles (R-NPs) are provided for selective transport into and through targeted tissues of therapeutic, prophylactic and diagnostic agents. R-NPs can include polymeric particle, lipid particles, inorganic particles, or a combination thereof with a targeting moiety selective for binding to a receptor on the cells where the agent is to be delivered, where the receptor mediates transcytosis of the nanoparticle into and through the cells. In a preferred embodiment, the targeting moiety is the neonatal Fc receptor. Examples demonstrate Fc-targeted nanoparticles which are actively transported across the intestinal epithelium, providing a route for the oral delivery of nanoparticle encapsulated active agents including peptides such as insulin. 1. A nanoparticle formulation for transport of agents through tissue , tissue barriers , and tissue linings comprising an effective amount of nanoparticles comprisinga polymeric, lipid or inorganic core comprising a therapeutic, prophylactic, or diagnostic agent, andtargeting moieties that bind to a receptor on the surface of the cells in the tissue to effect transcytosis of the nanoparticles into and through the cells, wherein the targeting moieties are bound to the surface of the nanoparticles.2. The nanoparticle formulation of for delivery into and through heart claim 1 , skeletal muscle claim 1 , or adipose tissue claim 1 , wherein the receptors are selected from the group consisting of gp60 and ligands for FcRn.3. The nanoparticle formulation of for delivery into and through testis tissue claim 1 , wherein the receptors are selected from the group consisting of chorionic gonadotropin receptor claim 1 , Insulin receptor and insulin-like growth factor receptor claim 1 , FcRn claim 1 , and Transferrin receptor.4. The nanoparticle formulation of for delivery into and through brain tissue claim 1 , wherein the receptors are selected from the group consisting of insulin receptor; insulin-like growth factor ...

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Номер записи: 71
07-01-2021 дата публикации

SYSTEM AND METHOD FOR MAKING MICROSPHERES AND EMULSIONS

Номер: US20210001290A1
Автор: Cramer Samantha, Galaska Rachel, Mahnen Cory, Minaghan Ford, Richey Tracy, Smith Mark
Принадлежит: OAKWOOD LABORATORIES, LLC

Various examples of systems and methods for making microspheres, microparticles, and emulsions are provided. In one example, a system and method for forming microspheres comprises: pumping a dispersed phase liquid and a continuous phase liquid into a levitating magnetic impeller pump to subject the dispersed phase liquid and continuous phase liquid to a high shear environment within the impeller pump's pump chamber. In another example, a system and method for forming an emulsion comprises: pumping a dispersed phase liquid and an inner aqueous phase liquid into a levitating magnetic impeller pump to subject the dispersed phase and the inner aqueous phase to a high shear environment within the impeller pump's pump chamber. 1. A system for forming microspheres , comprising: a dispersed phase input fitting at a first end,', 'a needle tube at a second end, and', 'a dispersed phase output fitting oriented between the dispersed phase input fitting and the needle tube,', 'wherein the dispersed phase needle has a hollow bore;, 'a dispersed phase needle including a plurality of tubes,', 'a tee input fitting or a wye input fitting,', 'a continuous phase input fitting, and', 'a continuous phase output fitting,', 'wherein the tubes each include a hollow bore; and, 'a tee or a wye including an input tube having an input fitting and a hollow bore,', 'a housing,', 'an output tube having an output fitting and a hollow bore,', 'a hollow interior, and', 'wherein the impeller includes a plurality of impeller blades and a base, wherein the base includes a magnet to magnetically engage a rotating magnetic field outside of the pump chamber, and wherein the impeller rotates and creates a direction of natural flow of a fluid through the pump chamber in a direction from the output tube toward the input tube.', 'an impeller is oriented within the hollow interior,'}], 'a pump chamber including2. The system of claim 1 , wherein the dispersed phase needle output fitting engages the tee input ...

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Номер записи: 72
07-01-2021 дата публикации

HOLLOW PARTICLES AND MANUFACTURING METHOD THEREOF, PORE FORMING MATERIAL, PARTICLES FOR COSMETICS, AND WEIGHT REDUCING MATERIAL

Номер: US20210001299A1
Автор: HATTA Masahiro
Принадлежит: FUJIFILM Corporation

According to an embodiment of the present invention, provided are hollow particles which have a wall portion containing polyurethane or polyurea, have an internal porous structure, and have a plurality of opening spaces blocked by the wall portion in an outermost portion of the porous structure, and a manufacturing method thereof, and a pore forming material, particles for cosmetics, and a weight reducing material. 1. Hollow particles which have a wall portion containing polyurethane or polyurea , have an internal porous structure , and have a plurality of opening spaces blocked by the wall portion in an outermost portion of the porous structure.2. The hollow particles according to claim 1 ,wherein the particles have a void volume of 10% to 90%.3. The hollow particles according to claim 1 ,wherein the particles have a spherical particle shape.4. The hollow particles according to claim 1 ,wherein the particles have a volume-based median diameter of 0.1 μm to 500 μm.5. A pore forming material comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the hollow particles according to .'}6. The pore forming material according to claim 5 ,wherein the material is used for manufacturing porous ceramics or a porous resin.7. Particles for cosmetics which have oil absorbability or water absorbability claim 5 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the hollow particles according to .'}8. A weight reducing material comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the hollow particles according to .'}9. A hollow particle manufacturing method comprising:dispersing an oil phase containing a polyfunctional isocyanate compound, a compound having a boiling point of 90° C. to 150° C., and at least one of a polyol or a polyamine in a water phase to prepare a dispersion liquid;heat-treating the dispersion liquid to polymerize at least the polyfunctional isocyanate compound, thereby forming a wall portion, and obtaining particles encapsulating the ...

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Номер записи: 73
07-01-2016 дата публикации

APPARATUS AND METHODS FOR MAKING VESICLES

Номер: US20160001290A1
Автор: Issadore David, Ko Jin A.
Принадлежит: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

A microfluidic device includes a substrate and a microfluidic channel embedded in the substrate. The microfluidic channel includes a plurality of fluid inlets, at least one waste outlet, at least one vesicle outlet, a flow junction joining the at least one vesicle outlet and the at least one waste outlet in fluid communication, the flow junction having a fluid flow path that is orthogonal to the plane of the substrate, and at least one membrane between the at least one vesicle outlet and the at least one waste outlet configured to intercept a portion of the fluid flow path. 1. A microfluidic device for generating vesicles comprising:a substrate; and a plurality of fluid inlets;', 'at least one waste outlet;', 'at least one vesicle outlet;, 'a microfluidic channel embedded in the substrate, the microfluidic channel includingto a flow junction joining the at least one vesicle outlet and the at least one waste outlet in fluid communication, the flow junction having a fluid flow path that is orthogonal to the plane of the substrate; andat least one membrane between the at least one vesicle outlet and the at least one waste outlet configured to intercept a portion of the fluid flow path.2. The microfluidic device of claim 1 , wherein the substrate is comprised of a polymer.3. The microfluidic device of claim 2 , wherein the substrate is comprised of polydimethylsiloxane.4. The microfluidic device of claim 1 , wherein the plurality of fluid inlets comprises a fluid inlet for a liquid and a fluid inlet for an emulsion.5. The microfluidic device of claim 4 , wherein the emulsion comprises a plurality of water-in-oil emulsion droplets.6. The microfluidic device of further comprising at least one emulsion droplet generator in fluid communication with the emulsion inlet.7. The microfluidic device of claim 1 , wherein the at least one membrane is a nanoporous membrane.8. The microfluidic device of claim 7 , wherein the nanoporous membrane is selected from the group consisting ...

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Номер записи: 74
04-01-2018 дата публикации

LIQUID-CORE CAPSULES COMPRISING NON-CROSSLINKED ALGINATE

Номер: US20180001291A1
Автор: DAGAN Orit, NUSSINOVITCH Amos
Принадлежит: YISSUM Research Development Company of the Hebrew University of Jerusalem LTD.

Provided are hydrocolloid core-shell capsules including a liquid core including a non-crosslinked alginate solution and a solid or semi-solid shell including a hydrocolloid other than alginate crosslinked with metal ions, which do not crosslink alginate. Further provided is a method for the preparation of the liquid-core capsules including non-crosslinked alginate. The subject matter further provides the use of the capsules, inter alia, in the water treatment technology. 140.-. (canceled)41. A hydrocolloid core-shell capsule comprising:a liquid core comprising a non-crosslinked alginate solution; anda solid or semi-solid shell comprising a hydrocolloid other than alginate crosslinked with metal ions, which do not crosslink alginate.42. The capsule according to claim 41 , wherein the metal ions are selected from the group consisting of magnesium ions claim 41 , potassium ions and sodium ions.43. The capsule according to claim 41 , wherein the concentration of the alginate solution ranges from about 1% (w/w) to about 10% (w/w).44. The capsule according to claim 41 , wherein the alginate solution has a concentration of calcium ions that is lower than about 0.01M.45. The capsule according to claim 41 , wherein the shell hydrocolloid is selected from gellan or k-carrageenan.46. The capsule according to claim 42 , wherein the concentration of magnesium ions claim 42 , which crosslink the shell hydrocolloid ranges from about 0.075 mM/g(hydrocolloid) to about 0.5 mM/g(hydrocolloid).47. The capsule according to claim 41 , wherein the shell further comprises at least one surfactant selected from the group consisting of lecithin claim 41 , sultaines CHAPS claim 41 , cocamidopropyl hydroxysultaine claim 41 , cocamidopropyl betaine claim 41 , phosphatidylserine claim 41 , phosphatidylethanolamine claim 41 , phosphatidylcholine claim 41 , sphingomyelin and combinations thereof.48. The capsule according to claim 41 , wherein the shell further comprises a polycation selected from ...

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Номер записи: 75
02-01-2020 дата публикации

Encapsulation System and Method

Номер: US20200001263A1
Автор: Batty Timothy R., Divvela Mounica Jyothi, Joo Yong Lak, Korah Mani, Zhmayev Yevgen
Принадлежит:

An encapsulation system and method including a solution having a first system with a first rate of removal, a second system with a second rate of removal, and a material soluble in the first system, but not soluble in the second system. The first rate of removal is quicker than the second rate of removal, and removal of the first system from the solution creates a concentration of the second system and the material migrates around the second system. Thus, the material creates a shell around the second system, generating a capsule with a shell of the material and a core of the second system. Such material may include a polymer, copolymer, or block copolymer, while the second system is poor solvent for the material, such as hexadecane or Oil Red O. The first system is a good solvent for the material and is readily removable from solution via evaporation during processes like electrospraying. 1. A tri-phase system for encapsulation , comprising:a first solvent having a first evaporation rate;a second solvent having a second evaporation rate;wherein the first evaporation rate is quicker than the second evaporation rate;a polymer positioned within the first solvent; andwherein evaporation of the first solvent results in a formation of an encapsulation by a concentration of the polymer around the second solvent.2. The tri-phase system of claim 1 , wherein one of the first solvent and the second solvent is hydrophilic and the other of the first solvent and the second solvent is hydrophobic.3. The tri-phase system of claim 1 , further comprising a hydrophobic material in the second solvent.4. The tri-phase system of claim 3 , wherein the hydrophobic material is a dye.5. The tri-phase system of claim 1 , wherein evaporation of the first solvent further results in the polymer migrating around the second solvent to form a shell around the second solvent.6. The tri-phase system of claim 1 , wherein the polymer is at least one of: poly methyl methacrylate (PMMA) claim 1 , ...

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Номер записи: 76
03-01-2019 дата публикации

AEROGELS, MATERIALS USING SAME, AND METHODS FOR PRODUCING SAME

Номер: US20190001293A1
Автор: Nakamura Taichi, OIKAWA Kazuma, Sakatani Shigeaki, TOYOTA KEI
Принадлежит:

Disclosed is an aerogel, having, on the surface of the aerogel, at least one type of dialkyldisiloxane bond serving as a hydrophobic group, and/or at least one type of crosslinked disiloxane bond serving as a hydrophobic group. Further disclosed is a material serving as at least one material selected from among a heat-insulation material, a sound-absorbing material, a water-repellant material, and an adsorption material, and this material includes the above-mentioned aerogel. Yet further disclosed is a method for producing the above-mentioned aerogel. 1. An aerogel comprising:a first aerogel having, on a surface of the first aerogel, at least one type of dialkyldisiloxane bond serving as a hydrophobic group; anda second aerogel having on a surface of the second aerogel one type of trialkylsiloxane bond.2. The aerogel according to claim 1 , wherein the alkyl groups present in the one type of dialkyldisiloxane bond each have a carbon number from 1 to 10.3. An aerogel claim 1 , according to claim 1 ,wherein the number of molecules of the first aerogel is about 0.5 to about 1.5 times greater than the number of molecules of the second aerogel.4. The aerogel according to claim 1 , wherein the alkyl groups present in the at least one type of trialkylsiloxane bond each have a carbon number from 1 to 10.5. (canceled)6. An aerogel claim 1 , comprising:an third aerogel having, on a surface of said third aerogel, at least one type of dialkyldisiloxane bond serving as a hydrophobic group, and/or at least one type of crosslinked disiloxane bond serving as a hydrophobic group; anda fourth aerogel having on a surface of said fourth aerogel at least one type of trialkylsiloxane serving as a hydrophobic group, wherein the number of molecules of the third aerogel is about 0.5 to about 1.5 times greater than the number of molecules of the fourth aerogel.7. The aerogel according to claim 6 , wherein the alkyl groups present in the at least one type of trialkylsiloxane bond each have a ...

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Номер записи: 77
03-01-2019 дата публикации

Method for Producing Colloidosome Microcapsules

Номер: US20190001294A1
Автор: Casanova Herley, Pérez Zapata César Augusto
Принадлежит:

This invention relates to a process for colloidosome-type microcapsules elaboration from solid particles microcapsules obtained by ionic gelation. In the process, an (O/W) type emulsion is initially generated stabilized with the solid particles microcapsules, and then the particles are fixed to the interface by adsorption of polyelectrolytes, cross-linking, heat treatment or fatty coating, generating the colloidosome with the water-insoluble phase encapsulated in the core and covered by the shell particles. 1) A process for elaborating colloidosomes-type microcapsules comprising:a) dispersing in water agglomerates of solid particles microcapsules obtained by ionic gelation to form a suspension;b) emulsify a liquid insoluble in water using as emulsifier the suspension obtained in a); andc) fix the solids adsorbed on the water-liquid interface insoluble in water, to obtain the colloidosomes.2) A process according to claim 1 , wherein the mixture obtained in c) is dried to obtain powder colloidosomes.3) A process according to claim 1 , wherein the microcapsules of step a) comprise water-insoluble solids selected from the group consisting of metallic and non-metallic minerals claim 1 , phyllosilicates claim 1 , polymer particles and insoluble solids obtained via synthesis claim 1 , extraction or by bioprocesses.4) A process according to claim 1 , wherein the solid particles microcapsules of step a) have a size between 10 nm and 1000 μm.5) A process according to claim 1 , wherein in step a) shear-type disruptive forces claim 1 , cavitation claim 1 , shock claim 1 , pressure drop or combinations thereof are applied to prevent the agglomerates formation.6) A process according to claim 1 , wherein the fixation of the adsorbed particles on the water-liquid interface water-insoluble of step c) is carried out by polyelectrolytes adsorption claim 1 , cross-linking claim 1 , heat treatment and/or treatment with a fatty acid emulsion or fatty acids mixture.7) A process according ...

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Номер записи: 78
07-01-2021 дата публикации

MICROSPHERE-BASED INSULATING MATERIALS FOR USE IN VACUUM INSULATED STRUCTURES

Номер: US20210002162A1
Автор: Deka Lakshya J., Ernat Nicole M., NIGAM ASHISH, Roy Shayta
Принадлежит: WHIRLPOOL CORPORATION

A low-density insulating material for use in a vacuum insulated structure for an appliance includes a plurality of microspheres that includes a plurality of leached microspheres. Each leached microsphere has an outer wall and an interior volume. The outer wall has a hole that extends through the outer wall and to the interior volume. A binder engages outer surfaces of the plurality of leached microspheres, wherein the binder cooperates with the plurality of leached microspheres to form at least one microsphere aggregate. The interior volume of each leached microsphere defines an insulating space that includes an insulating gas. The insulating space of each leached microsphere is at least partially defined by the binder. 147-. (canceled)48. A low-density insulating material for use in a vacuum insulated structure for an appliance , the low-density insulating material comprising:a plurality of microspheres that includes a plurality of leached microspheres, each leached microsphere having an outer wall and an interior volume, wherein the outer wall has a hole that extends through the outer wall and to the interior volume; and the interior volume of each leached microsphere defines an insulating space that includes an insulating gas; and', 'the insulating space of each leached microsphere is at least partially defined by the binder., 'a binder that engages outer surfaces of the plurality of leached microspheres, wherein the binder cooperates with the plurality of leached microspheres to form at least one microsphere aggregate; wherein'}49. The low-density insulating material of claim 48 , wherein the binder engages the outer surface of each leached microsphere claim 48 , wherein the binder is disposed within a portion of the holes of the plurality of leached microspheres.50. The low-density insulating material of claim 48 , wherein the insulating gas includes at least one of carbon dioxide claim 48 , argon claim 48 , xenon claim 48 , krypton and neon.51. The low-density ...

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Номер записи: 79
04-01-2018 дата публикации

METHOD OF PREPARING HYDROPHOBIC METAL OXIDE-SILICA COMPOSITE AEROGEL AND HYDROPHOBIC METAL OXIDE-SILICA COMPOSITE AEROGEL PREPARED THEREBY

Номер: US20180002182A1
Автор: JEON Hyun Woo, Kim Jong hun, Lee Je Kyun
Принадлежит:

The present invention relates to a method of preparing a hydrophobic metal oxide-silica composite aerogel having a high specific surface area and a low tap density and a hydrophobic metal oxide-silica composite aerogel prepared thereby. Thus, the preparation method may not only have excellent productivity and economic efficiency due to a relatively simpler preparation process and shorter preparation time than the related art, but may also prepare a hydrophobic metal oxide-silica composite aerogel having a high specific surface area and a low tap density. 1. A method of preparing a hydrophobic metal oxide-silica composite aerogel , the method comprising steps of:(1) adding a metal ion solution and an acid catalyst to a water glass solution and mixing together to prepare a metal oxide-silica composite gel;(2) surface-modifying the metal oxide-silica composite gel to prepare a hydrophobic metal oxide-silica composite wet gel; and(3) drying the hydrophobic metal oxide-silica composite wet gel,wherein the method further comprises treating the metal oxide-silica composite gel with alcohol before the surface modification of step 2.2. The method of claim 1 , wherein a concentration of water glass in the water glass solution is in a range of 0.1 M to 2.0 M.3. The method of claim 1 , wherein a concentration of metal ions in the metal ion solution is in a range of 0.05 M to 2.0 M.4. The method of claim 1 , wherein the metal ion solution is a binary metal ion solution including calcium ions (Ca) and magnesium ions (Mg).5. The method of claim 4 , wherein a molar ratio of the calcium ion (Ca) to the magnesium ion (Mg) in the metal ion solution is in a range of 1:0.3 to 1:3.6. The method of claim 1 , wherein the metal ion solution is added in an amount such that a molar ratio of metal ions to water glass is in a range of 0.5 to 1.7. The method of claim 1 , wherein step 1 is performed at a pH of 6 to 8.8. The method of claim 1 , wherein the acid catalyst comprises at least one ...

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Номер записи: 80
03-01-2019 дата публикации

VOIDED LATEX PARTICLES CONTAINING FUNCTIONALIZED OUTER SHELLS

Номер: US20190002710A1
Автор: Boudreaux Matthew F., Liu Lily, Olesen Keith R.
Принадлежит:

The wet adhesion of a coating composition may be improved through the use of voided latex particles as opacifying agents which contain a hollow interior as well as an outer shell of a polymer containing functional groups such as amino, 1,3-diketo, urea or ureido. Other types of functional groups may be introduced to the outer shell polymer in order to vary other desired characteristics of the coating. The voided latex particles are non-film-forming. 1. A voided latex particle comprising a hollow interior and an outer shell , wherein the outer shell is comprised of an outer shell polymer having a Tg of at least above 45° C. and bearing functional groups selected from 1 ,3-diketo , amino , ureido , urea , hydroxyl , polyether , silane , phosphate , epoxy , fluorocarbon , aldehyde , ketone , acetoacetyl , functional groups or combinations thereof and wherein the voided latex particle is non-film-forming and opaque.2. The voided latex particle of claim 1 , wherein the outer shell polymer is a copolymer of a vinyl aromatic polymer and a free radical polymerizable ethylenically unsaturated monomer containing a ureido or urea functional group.3. The voided latex particle of claim 2 , wherein the vinyl aromatic monomer styrene.4. The voided latex particle of claim 2 , wherein the free radical polymerizable ethylenically unsaturated monomer contains a (meth)acrylate or (meth)acrylamide group.5. The voided latex particle of claim 2 , wherein the free radical polymerizable ethylenically unsaturated monomer is an imidazolidinone (meth)acrylic monomer.6. The voided latex particle of claim 2 , wherein the free radical polymerizable ethylenically unsaturated monomer is selected from the group consisting of 2-(2-oxo- 1-imidazolidinyl)ethyl (meth)acrylates and N-(2-(2-oxo-1-imidazolidinyl)ethyl (meth)acrylamides.7. The voided latex particle of claim 2 , wherein the copolymer contains from 0.1 to 10 weight % of the free radical polymerizable ethylenically unsaturated monomer.8. The ...

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Номер записи: 81
02-01-2020 дата публикации

Process

Номер: US20200002651A1
Автор: Bernard Julien, CHARLOT Aurelia, FLEURY ETIENNE, SALLET Pauline
Принадлежит:

A method of providing a modifier on the surface of an active-containing core-shell aminoplast microcapsule, including the covalent attachment of the modifier to the capsule shell surface by means of a coupling compound capable of covalent bonding to both shell and modifier by means of epoxy groups on the coupling compound. The method is especially useful for enhancing the substantiveness to fabrics of fragrance microcapsules added to laundry products. 1. A method of providing a modifier on the surface of an active-containing core-shell aminoplast microcapsule , comprising the covalent attachment of the modifier to the capsule shell surface by means of a coupling compound capable of covalent bonding to both shell and modifier by means of epoxy groups on the coupling compound.2. The method according to claim 1 , in which the shell is of melamine-formaldehyde resin.3. The method according to claim 1 , in which the modifier is selected from a polysaccharide and an enzyme.4. The method according to claim 3 , in which the enzyme is a lipase.5. The method according to claim 1 , in which the coupling compound is poly(ethylene glycol) diglycidyl ether having an Mof from 300-10 claim 1 ,000.6. The method according to claim 1 , in which the coupling compound is glycidyl methacrylate.7. The method according to claim 6 , in which the epoxy group of the glycidyl methacrylate is first reacted with the aminoplast of the shell claim 6 , and free-radical addition polymerisation is then initiated with other glycidyl methacrylate molecules claim 6 , to provide a plurality of epoxy groups.8. The method according to claim 1 , in which the coupling compound is first attached covalently to the shell claim 1 , and subsequently is covalently attached to the modifier.9. The method according to claim 1 , in which the coupling compound is first attached covalently to the modifier claim 1 , and subsequently is covalently attached to the shell.10. The method according to in which the modifier is ...

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Номер записи: 82
07-01-2021 дата публикации

Microencapsulation Using Amino Sugar Oligomers

Номер: US20210002588A1
Автор: Andersen Casper Orsoe, Andersen Kim Bruno, Simonsen Ole
Принадлежит: NOVOZYMES A/S

The present invention provides a microcapsule composition produced by crosslinking of oligomers comprising amino sugars, which is used for stabilizing detergent components. 1. A microcapsule composition , comprising a compound entrapped in an aqueous compartment formed by a membrane , wherein the membrane surrounds the compartment and comprises cross-linked amino sugar oligomers.2. The composition of claim 1 , wherein the compound is a detergent enzyme.3. The composition of claim 2 , wherein the detergent enzyme is selected from the group consisting of protease claim 2 , metalloprotease claim 2 , subtilisin claim 2 , amylase claim 2 , lipase claim 2 , cutinase claim 2 , cellulase claim 2 , mannanase claim 2 , pectinase claim 2 , xanthanase claim 2 , DNase claim 2 , laccase claim 2 , peroxidase claim 2 , haloperoxidase claim 2 , perhydrolase claim 2 , and combinations thereof.4. The composition of claim 2 , wherein the compartment contains at least 1% active enzyme by weight of the total compartment.5. The composition of claim 1 , wherein the diameter of the compartment is at least 50 micrometers.6. The composition of claim 1 , which further includes an alcohol.7. The composition of claim 1 , wherein the amino sugar oligomers comprise at least 60% w/w of amino sugar monomers.8. The composition of claim 1 , wherein the amino sugar oligomers comprise at least 60% w/w of glucosamine monomers.9. The composition of claim 1 , wherein the amino sugar oligomers are chitosan oligomers.10. The composition of claim 1 , wherein the amino sugar oligomers are composed of randomly distributed β(1→4)-linked glucosamine and N-acetyl-glucosamine.11. The composition of claim 1 , wherein the amino sugar oligomers have a weight average molecular weight (M) of 300 to 15000 Daltons.12. The composition of claim 1 , wherein the amino sugar oligomers have a weight average molecular weight (M) of 300 to 5000 Daltons.13. The composition of claim 1 , wherein the membrane is produced by using an ...

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Номер записи: 83
13-01-2022 дата публикации

BIODEGRADABLE MICROCAPSULES

Номер: US20220008886A1
Автор: AKEROYD Niels, ANQUETIN Florine, GARCIA CAVERO Pedro, Hunter Robert Allan, LEI Yabin, LUCA VILCIU Florin, Popplewell Lewis Michael, STOICA Sonia-Patricia, WIELAND Julie, Xu Li
Принадлежит:

Disclosed are biodegradable core-shell microcapsule compositions composed of microcapsules having a wall formed by self-condensation of an isocyanate in the presence of a denatured pea protein as dispersant. Also disclosed are consumer products containing such a core-shell microcapsule composition and methods for producing core-shell microcapsule compositions. 1. A core-shell microcapsule composition comprising:(a) microcapsules having a mean diameter of 1 to 100 microns, the core of the microcapsules comprises an active material and the shell of the microcapsules comprises a trimethylol propane-adduct of xylylene diisocyanate;(b) a dispersant comprising denatured pea protein; and(c) a hydrocolloid comprising gum arabic.2. The core-shell microcapsule composition of claim 1 , further comprising least one rheology modifier claim 1 , preservative claim 1 , emulsifier claim 1 , or a combination thereof.3. The core-shell microcapsule composition of claim 2 , wherein the rheology modifier comprises xanthan gum.4. The core-shell microcapsule composition of claim 1 , wherein the trimethylol propane-adduct of xylylene diisocyanate is present at 0.1% to 8% by weight of the core-shell microcapsule composition.5. The core-shell microcapsule composition of claim 1 , wherein the active material comprises at least one fragrance claim 1 , pro-fragrance claim 1 , malodor counteractive agent claim 1 , or a combination thereof.6. A consumer product comprising the core-shell microcapsule composition of .7. The consumer product of claim 6 , wherein the consumer product is a fabric softener claim 6 , a fabric refresher claim 6 , or a liquid laundry detergent.8. A method for producing a core-shell microcapsule composition comprising: (i) denaturing a pea protein,', '(ii) adjusting the pH to below 6, and', '(iii) adding gum arabic as a hydrocolloid;, '(a) preparing an aqueous phase by'}(b) preparing an oil phase comprising an active material and a trimethylol propane-adduct of xylylene ...

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Номер записи: 84
13-01-2022 дата публикации

METHOD FOR PRODUCING AEROGELS AND AEROGELS OBTAINED USING SAID METHOD

Номер: US20220009786A1
Автор: HINTEMANN Damian, KILZER Andreas, MÖLDERS Nils, RENNER Manfred, SENGESPEICK Andreas, WEIDNER Eckhard, WEISHAUPT Oliver
Принадлежит:

The invention relates to a method for producing an aerogel under increased pressure, to the aerogel obtained using said method and to their use. 1. A method for producing a silica aerogel by means of a sol-gel process , comprisingproducing a lyogel from a sol; andconverting the lyogel into an aerogel, whereinthe production of the lyogel is carried out at least partially at a pressure of more than 30 bar.2. The method according to claim 1 , wherein the production of the lyogel is carried out in a compressed gas claim 1 , a supercritical substance claim 1 , or a mixture of both.3. The method according to claim 1 , wherein:the pressure is selected from more than 40 bar, more than 50 bar, more than 60 bar, more than 70 bar, and more than 74 bar; and/orthe production of the lyogel is carried out at a temperature selected from above 50° C., 60° C., 70° C., and 80° C.4. The method according to claim 1 , wherein converting the lyogel into an aerogel is carried out at a pressure of more than 50 bar.5. The method according to claim 1 , wherein the sol is a solution or a dispersion of a precursor.6. The method according to claim 5 , wherein the precursor is selected from silicic acids claim 5 , in particular colloidal silicic acid claim 5 , colloidal silica claim 5 , silanes claim 5 , silica sols claim 5 , tetraalkoxysilanes claim 5 , siloxanes and mixtures thereof.7. The method according to claim 1 , wherein the sol comprises a hydrophobing silanizing agent.8. The method according to claim 1 , wherein the production of the lyogel is carried out by introducing the sol into a pressurized apparatus in the form of droplets.9. The method according to claim 1 , wherein after the production of the lyogel a solvent exchange is performed.10. The method according to claim 9 , wherein the solvent exchange occurs by contacting the lyogel with an organic solvent at elevated pressure.11. The method according to claim 10 , wherein the organic solvent is brought into contact with the lyogel ...

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Номер записи: 85
20-01-2022 дата публикации

SEMICONDUCTOR NANOPARTICLES AND METHOD OF PRODUCING SEMICONDUCTOR NANOPARTICLES

Номер: US20220017819A1
Автор: KAMEYAMA Tatsuya, Kuwabata Susumu, NIKI Kenta, OYAMATSU Daisuke, TORIMOTO Tsukasa, UEMATSU Taro, WAJIMA Kazutaka
Принадлежит:

A semiconductor nanoparticle includes a core and a shell covering a surface of the core. The shell has a larger bandgap energy than the core and is in heterojunction with the core. The semiconductor nanoparticle emits light when irradiated with light. The core is made of a semiconductor that contains M, M, and Z. Mis at least one element selected from the group consisting of Ag, Cu, and Au. Mis at least one element selected from the group consisting of Al, Ga, In and Tl. Z is at least one element selected from the group consisting of S, Se, and Te. The shell is made of a semiconductor that consists essentially of a Group 13 element and a Group 16 element. 1. A semiconductor nanoparticle comprising:a core comprising a semiconductor being adapted to emit photoluminescence upon being irradiated with light; anda shell covering a surface of the core and having a bandgap energy larger than a bandgap energy of the core, the shell being in heterojunction with the core,{'sup': 1', '2', '1, 'claim-text': [{'sup': '2', 'Mis at least one element selected from the group consisting of Al, Ga, In, and Tl, and comprises at least In,'}, 'and Z is at least one element selected from the group consisting of S, Se, and Te, and comprises at least S,, 'wherein the semiconductor contains M, M, and Z, wherein Mis at least one element selected from the group consisting of Ag, Cu, and Au, and comprises at least Ag,'}wherein the shell comprises a semiconductor containing a Group 13 element and a Group 16 element, andwherein a photoluminescence lifetime of the semiconductor nanoparticles is 200 ns or less.2. The semiconductor nanoparticle according to claim 1 , wherein the shell contains In as the Group 13 element.3. The semiconductor nanoparticle according to claim 2 , wherein the shell contains S as the Group 16 element.4. The semiconductor nanoparticle according to claim 1 , wherein the shell contains Ga as the Group 13 element.5. The semiconductor nanoparticle according to claim 4 , wherein ...

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Номер записи: 86
12-01-2017 дата публикации

MICROPARTICLES WITH EFFICIENT BIOACTIVE MOLECULE INCORPORATION

Номер: US20170007546A1
Автор: BOHMER Marce Rene, CHLON Caecilia Hendrina Theodora
Принадлежит:

The present invention relates to, drug-filled polymeric microparticles comprising a gas core and shell that combine high incorporation efficiency for hydrophilic and/or hydrophobic drugs with a large, preferably hollow, core. 1. A polymer microparticle with a microparticle size ranging between 0.5 and 5 μm comprising a biologically active agent prepared by:a) providing a first emulsion (A) by mixing an organic solvent (1), a biodegradable polyester, and an organic non-solvent for the polymer (2), wherein the ratio of biodegradable polyester/organic non-solvent (2) is 1:10 to 1:1% w/w, and adding to this mixture up to 40% v/v of an aqueous solution and wherein a biologically active agent is added to the organic mixture and or aqueous solution;b) preparing a second emulsion (B) by adding to this first emulsion (A) excess of an aqueous solution;c) applying conditions for volatizing the organic solvent (1);d) applying conditions for removal of water; ande) applying conditions for removal of the non-solvent (2).2. A polymer microparticle according to claim 1 , wherein the biodegradable polyester has a molecular weight between 1.000 and 200.000 g/mol.3. A polymer microparticle according to claim 1 , wherein the the ratio biodegradable polyester/organic non solvent (2) is 1:8 to 1:34. A polymer microparticle according to claim 1 , wherein a non solvent (3) that is not removed in step e) is added to step a).5. A polymer microparticle according to wherein the polymer is selected from the group comprising polylactide either in the L or DL form claim 1 , poly-lactide-co-glycolide claim 1 , polycaprolacton claim 1 , a combination thereof claim 1 , or a block co-polymer thereof.6. A polymer microparticle according to claim 5 , wherein the polymer comprises at least one moiety modified with at least one hydrophobic group that is preferably selected from the group comprising fluoride claim 5 , alkyl chain comprising from 6 to 24 carbon atoms or a combination of these.7. A polymer ...

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Номер записи: 87
14-01-2021 дата публикации

METHOD FOR PREPARING PARTICLES COMPRISING METAL OXIDE COATING AND PARTICLES WITH METAL OXIDE COATING

Номер: US20210007996A1
Автор: Abu-Reziq Raed, Bar-Simantov Haim, Bilman Nissim, Sertchook Hanan, Shapiro Leora, Toledano Ofer
Принадлежит: SOL-GEL TECHNOLOGIES LTD.

The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles. 1. Particles comprising solid benzoyl peroxide particulate matter encapsulated by a metal oxide coating , wherein the metal oxide coating comprises four or more layers; whereinhe outermost portion of the metal oxide coating being substantially free of benzoyl peroxide; wherein the weight ratio of the metal oxide to said benzoyl peroxide, is in the range of 1:99 to 40:60;the coated particles having leaching of less than 5% w/w, of the benzoyl peroxide in the composition until administered to the skin;the coated particles release an effective amount of benzoyl peroxide when the composition is in contact with the surface; andthe time for releasing 50% w/w of the benzoyl peroxide being at least two-fold longer when in coated form than the time to dissolution of benzoyl peroxide particles of the same particle size diameter when in free form under identical conditions.2. The particles according to claim 1 , wherein said metal oxide coating has a thickness of 0.1-10 micron.3. Particles comprising solid benzoyl peroxide particulate matter encapsulated by a metal oxide coating ...

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Номер записи: 88
10-01-2019 дата публикации

MICROENCAPSULATION OF B-ALANINE

Номер: US20190008786A1
Автор: Chen Jianbin, Li Qian, LI Xiangcheng, WU Wenzhong
Принадлежит: Innobio Corporation Limited

Microencapsulation of β-alanine uses β-alanine as a core material and a mixture of a wall material and an additive as a release material. The additive comprises: a fatty acid-based saturated or unsaturated fatty acid glyceride containing 12-22 carbon atoms and a phospholipid. The fatty acid glyceride is a mono-fatty acid glyceride or a di-fatty acid glyceride, or a mixture formed by mixing the mono-fatty acid glyceride and the di-fatty acid glyceride at arbitrary proportions. The microencapsulation technique solves problems occurring with the use of β-alanine as a raw material, such as high moisture absorption tendency thereof, unpleasant smell and stinging accompanying administration of the same. The invention selects and combines the wall material and the additive to attain a balance between embedment and release with respect to a microencapsulated β-alanine product, and effectively optimizes release kinetics of the product, thereby enabling a stable release of the product, and realizing effective embedment and uniform release. Therefore, the microencapsulated β-alanine is applicable to the preparation of food, drugs, health-enhancing products and functional food. 1. A microencapsulated β-alanine using β-alanine as a core material and a mixture of a wall material and an additive as a release material , wherein the additive comprises a fatty acid-based saturated or unsaturated fatty glyceride containing 12 to 22 carbon atoms and a phospholipid; and the fatty glyceride is a monoglyceride , a diglyceride , or a mixture thereof in any ratio.2. The microencapsulated β-alanine according to claim 1 , wherein the fatty glyceride is selected from the fatty acid-based fatty glyceride containing 16 to 18 carbon atoms.3. The microencapsulated β-alanine according to claim 2 , wherein the fatty glyceride comprises any one of the followings: glyceryl hexadecanoate claim 2 , glyceryl hexadecenoate claim 2 , glyceryl octadecanoate claim 2 , glycerol octadecenoate claim 2 , ...

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Номер записи: 89
10-01-2019 дата публикации

PROCESS FOR ENCAPSULATING SOLUBLE BIOLOGICS, THERAPEUTICS, AND IMAGING AGENTS

Номер: US20190008788A1
Автор: "Prudhomme Robert K.", MARKWALTER Chester E., PAGELS Robert F.
Принадлежит: THE TRUSTEES OF PRINCETON UNIVERSITY

An “inverse” precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described. The aggregation of these nanoparticles to form larger microparticles and monoliths provides a highly loaded construct (e.g., a depot) for the sustained and controlled release of actives. 1. A method for encapsulating a water soluble agent comprising:making an inverse nanoparticle dispersion by dissolving the water soluble agent in a first polar process solvent to form a water soluble agent solution,dissolving a copolymer in a second polar process solvent to form a copolymer solution,continuously mixing the water soluble agent solution and the copolymer solution with a nonprocess solvent to form a mixed solution from which inverse nanoparticles assemble to form an inverse nanoparticle dispersion, andaggregating the inverse nanoparticles to form microparticles or larger constructs to encapsulate the water soluble agent,wherein the copolymer comprises at least one region that is more polar and at least one region that is less polar,wherein the nonprocess solvent is less polar than the first polar process solvent,wherein the nonprocess solvent is less polar than the second polar process solvent,wherein the inverse nanoparticle comprises a core and a shell,wherein the core comprises the more polar region of the copolymer and the water soluble agent,wherein the shell comprises the less polar region of the copolymer, andwherein the mixing causes no more than 20 percent by volume of the first polar process solvent and the second polar process solvent to phase separate from the mixed solution.2. The method of claim 1 , wherein the water soluble agent is selected from the group consisting of a biologic material claim 1 , an amino acid claim 1 , a peptide claim 1 , a protein claim 1 , an antibody claim 1 , DNA claim 1 , RNA claim 1 , mRNA claim 1 , siRNA claim 1 , a saccharide claim 1 , glutathione claim ...

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Номер записи: 90
11-01-2018 дата публикации

ENCAPSULATION METHOD

Номер: US20180008948A1
Автор: Bibette Jérôme, WALTERS Jamie Dean
Принадлежит: CALYXIA

The present invention relates to a method for preparing solid capsules comprising a compound A, dispersed in a composition C4. 1. A method for preparing solid capsules , comprising the following steps: C1 and C2 not being miscible with each other,', 'C2 being at temperature T2,', 'whereby an emulsion is obtained comprising drops of composition C1 dispersed in the composition C2,, 'a) adding with stirring a composition C1 comprising at least one compound A, in a liquid composition C2 comprising a thermo-expansible material,'} C3 and C2 not being miscible with each other,', 'C3 being at temperature T3, preferably equal to T2,', 'whereby an emulsion is obtained comprising drops dispersed in the composition C3,, 'b) addition with stirring of the emulsion obtained in step a) into a liquid composition C3 able to be polymerized,'} C4 and C3 not being miscible with each other,', 'C4 being at temperature T4 less than or equal to T2 and less than or equal to T3,', 'whereby an emulsion is obtained comprising drops dispersed in the composition C4, and, 'c) addition with stirring of the emulsion obtained in step b) in a liquid composition C4,'}d) polymerization of the drops obtained in step c),whereby solid capsules are obtained, dispersed in the composition C4.2. The method according to claim 1 , wherein the composition C1 is a solution comprising the compound A in a solubilized form.3. The method according to claim 1 , wherein the composition C1 is an emulsion formed with drops of a solution comprising the compound A in a solubilized form claim 1 , said drops being dispersed in a composition C′3 able to be polymerized.4. The method according to claim 1 , wherein after step b) and before step c) claim 1 , steps a) and b) are repeated at least once.5. The method according to claim 1 , wherein the thermo-expansible material is selected from the group consisting of waxes claim 1 , fluorocarbons claim 1 , and mixtures thereof.6. The method according to claim 1 , wherein the thermo- ...

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Номер записи: 91
12-01-2017 дата публикации

METHOD FOR PRODUCING A FUSION MIXTURE FOR TRANSFER OF A CHARGED MOLECULE INTO AND/OR THROUGH A LIPID MEMBRANE

Номер: US20170009255A1
Автор: Csiszar Agnes, Hersch Nils, Hoffmann Bernd, Hoffmann Marco, Merkel Rudolf, Zantl Roman
Принадлежит:

A method for producing a fusion mixture for a transfer of a charged molecule into and/or through a lipid membrane is disclosed. In an embodiment, the method comprises: providing an initial mixture comprising a positively charged amphipathic molecule A, an aromatic molecule B with hydrophobic range and a neutral, amphipathic molecule C, whereby the molecule types are at hand in a ratio A:B:C of 1-2:0.02-1:0-1 mol/mol; generating a fusogenic liposome by absorption of the initial mixture in a watery solvent; providing a charged molecule; forming a complex from the charged molecule and a neutralizing agent; and incubating the complex with the fusogenic liposome so that a fusion mixture is obtained. 117.-. (canceled)18. A method for producing a fusion mixture for a transfer of a charged molecule into and/or through a lipid membrane comprising:a) providing an initial mixture comprising a positively charged amphipathic molecule A, an aromatic molecule B with hydrophobic range and a neutral, amphipathic molecule C, whereby the molecule types are at hand in a ratio A:B:C of 1-2:0.02-1:0-1 mol/mol,b) generating a fusogenic liposome by absorption of the initial mixture in a watery solvent,c) providing a charged molecule,d) forming a complex from the charged molecule and a neutralizing agent, ande) incubating the complex with the fusogenic liposome so that a fusion mixture is obtained.19. The method according to claim 18 , wherein step d) occurs in a manner that the complex has a zeta potential of −50 mV to 0 mV.20. The method according to claim 18 , wherein before step e) an adding of cations occurs in order to stabilize the complex.21. The method according to claim 20 , wherein the cations are added with a concentration of 0 to 1 mM.22. The method according to claim 18 , wherein step d) comprises an adding of albumin.23. The method according to claim 18 , wherein before claim 18 , during and/or after step e) a lipid membrane destabilizing agent is added.24. The method ...

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Номер записи: 92
14-01-2021 дата публикации

PROCESS FOR PREPARING MICROCAPSULES WITH IMPROVED DEPOSITION

Номер: US20210008518A1
Автор: Han Lei, Ouali Lahoussine, Shi Lei
Принадлежит:

Described herein is a process for producing perfume- or flavor-containing microcapsules with improved deposition of encapsulated actives on targeted surfaces such as fiber, hair and skin, which can be used in home or personal care products. Also described herein are microcapsules obtainable by such a process and consumer products including these microcapsules. 2. The process according to claim 1 , characterized in that the ionic polyvinyl alcohol is an anionic polyvinyl alcohol.3. The process according to claim 1 , wherein the cationic polymer is selected from the group consisting of quaternized copolymers of vinylpyrrolidone and dimethylaminoethyl methacrylate claim 1 , copolymers of vinylpyrrolidone and methacrylamidopropyl trimethylammonium chloride claim 1 , polydiallyldimethyl ammonium chloride claim 1 , copolymers of allyl dimethyl ammonium chloride/acrylamide and copolymers of acrylamidopropyltrimonium chloride and acrylamide claim 1 , cationic copolymers of vinylpyrrolidone and of a quaternized vinylimidazol claim 1 , guar hydroxypropyltrimonium chloride claim 1 , hydrophobically modified cationic hydroxyethylcellulose and mixtures thereof.4. The process according to claim 1 , characterized in that a cross-linker selected from the group consisting of an amine claim 1 , a polyol and a mixture thereof is added during step c).5. The process according to claim 4 , characterized in that the amine is selected from the group consisting of 1 claim 4 ,2-diaminopropane claim 4 , 1 claim 4 ,2-diaminoethane claim 4 , diethylenetriamine claim 4 , guanidine claim 4 , water soluble guanidine salts claim 4 , tris-(2-aminoethyl)amine claim 4 , N claim 4 ,N claim 4 ,N′ claim 4 ,N′-tetrakis(3-aminopropyl)-1 claim 4 ,4-butanediamine claim 4 , N claim 4 ,N′-bis(3-aminopropyl)-ethylenediamine and 3 claim 4 ,5-diamino-1 claim 4 ,2 claim 4 ,4-triazole claim 4 , and mixtures thereof.6. The process according to claim 1 , characterized in that microcapsules are polyurea microcapsules ...

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Номер записи: 93
27-01-2022 дата публикации

ENCAPSULATION BY CROSS-LINKING OF ANIONIC POLYMERS BY PH INDUCED DISSOCIATION OF CATION-CHELATE COMPLEXES

Номер: US20220025132A1
Автор: Scher Herbert B., Strobel Scott, Wong Dana, Zicari Tina Jeoh
Принадлежит: The Regents of the University of California

Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously. 1. A method of cross-linking polymer molecules , the method comprising:(a) providing a solution of an acidic chelating agent with a volatile base;(b) adding at least one source of multivalent cations to form cation-chelate complexes in the solution;(c) mixing molecules of at least one anionic polymer with the solution of cation-chelate complexes and volatile base; and(d) vaporizing the volatile base of the solution, thereby disassociating the cation-chelate complexes and releasing multivalent cations and cross-linking the polymer molecules with said multivalent cations.2. The method of claim 1 , said acidic chelating agent solution further comprising a weak acid buffer.3. The method of claim 2 , wherein said weak acid is an acid selected from the group consisting of benzoic acid claim 2 , lactic acid claim 2 , ascorbic acid claim 2 , adipic acid claim 2 , acrylic acid claim 2 , glutaric acid claim 2 , ascorbic acid claim 2 , gallic acid claim 2 , caffeic acid claim 2 , L-Tartaric acid claim 2 , D-Tartaric acid claim 2 , ...

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Номер записи: 94
27-01-2022 дата публикации

Coacervation process to encapsulate organic pigments that show improved weather fastness

Номер: US20220025186A1
Автор: Benjamin Rene Harald STOMPS, Gabriela Catanoiu, Jennifer Schwarz, Simon ABEN, Udo Franz HASELWANDER
Принадлежит: COLORANTS INTERNATIONAL LTD

In a first aspect, the present invention relates to an encapsulated organic pigment comprising of an organic pigment as core material and a material capable of forming microcapsules as shell material, wherein the particle size of the encapsulated pigment (core-shell-product) is in the range from 50 nm to 500 μm and the particle size distribution D 90 is <100 μm.

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Номер записи: 95
11-01-2018 дата публикации

CAPSULES HAVING SURFACTANT TETHERED OUTER SHELLS AND METHODS FOR MAKING SAME

Номер: US20180009996A1
Автор: LENTZ Carl M, RYAN Kayla L. M.
Принадлежит:

Microcapsules are disclosed that have a core composition encapsulated within a polymer wall, and an inorganic shell connected to an exterior surface of the polymer wall by a surfactant. The inorganic shell has a cation attracted to the surfactant and an anion or anion equivalent chemically bonded to the cation to form the shell or has the metal portion of a metal-containing compound attracted to the surfactant to form the shell. The shell may comprise a Ca, Mg, or Ag metal compound. The shell may be a graphene oxide-metal compound. 1. A capsule comprising:a core composition encapsulated within a polymer wall; andan inorganic shell connected to an exterior surface of the polymer wall by a surfactant, the inorganic shell comprising a cation attracted to the surfactant and an anion or anion equivalent chemically bonded to the cation or a metal-containing compound attracted to the surfactant;wherein the surfactant comprises an ionic surfactant.2. The capsule of claim 1 , wherein the core comprises a phase change material.3. The capsule of claim 1 , wherein the cation is selected from the group consisting of calcium ions claim 1 , silver ions claim 1 , magnesium ions claim 1 , iron ions claim 1 , copper ions claim 1 , and cobalt ions claim 1 , and combinations thereof.4. The capsule of claim 3 , wherein the cation is a silver ion claim 3 , and the inorganic shell has antibacterial and antifungal growth properties.5. The capsule of claim 3 , wherein the inorganic shell provides the capsule with a flame retardant property that reduces the percent of total mass burned claim 3 , compared to the capsule without the shell claim 3 , by at least 16% mass.6. The capsule of claim 5 , wherein the inorganic shell reduces the percent of total mass burned by at least 40%.7. The capsule of claim 2 , wherein the full or partial inorganic shell comprises a cation and an anion claim 2 , and is selected from the group consisting of CO claim 2 , HPO claim 2 , PO claim 2 , SO claim 2 , SO ...

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Номер записи: 96
11-01-2018 дата публикации

MICROCAPSULES HAVING DUAL REAGENTS SEPARATED BY THE CAPSULE WALL AND METHODS FOR MAKING SAME

Номер: US20180010013A1
Автор: Lentz Carl M., RYAN Kayla L. M.
Принадлежит:

Ruptureable, dual reagent mono-capsules are disclosed that have a core composition, which includes a first reagent, encapsulated within a polymer wall, and a shell connected to an exterior surface of the polymer wall by a surfactant. The shell is made from a second reagent that is chemically bonded to the surfactant by a chemical electrostatic interaction. Upon rupture of the polymer wall of the mono-capsule, the first reagent and the second reagent chemically react with one another to form a reaction product. 1. A ruptureable capsule comprising:a core composition encapsulated within a polymer wall, the core composition comprising a first reagent; anda shell connected to an exterior surface of the polymer wall by a surfactant, the shell comprising a second reagent attracted to the surfactant by a chemical electrostatic interaction;wherein, upon rupture of the polymer wall, the first reagent and the second reagent chemically react with one another to form a reaction product.2. The capsule of claim 1 , wherein the reaction product seals the rupture in the capsule or seals a feature of a surface upon which the capsules are disposed.3. The capsule of claim 1 , wherein the second reagent comprises a mineral containing a metal that is available for chemical attraction or bonding to the surfactant claim 1 , and the first reagent is a carboxylic acid.4. The capsule of claim 3 , wherein the metal is selected from the group consisting of aluminum calcium claim 3 , silver claim 3 , magnesium claim 3 , iron claim 3 , copper claim 3 , and cobalt claim 3 , and combinations thereof.5. The capsule of claim 3 , wherein the metal is an aluminum.6. The capsules of claim 1 , wherein the second reagent is an inorganic compound and the shell connected to the exterior surface of the polymer wall by the surfactant is crystalline.7. The capsule of claim 6 , wherein the core composition comprises a natural oil claim 6 , and the inorganic compound catalyzes a reaction of the natural oil.8. ...

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Номер записи: 97
14-01-2021 дата публикации

WATER RESISTANT VOIDED POLYMER PARTICLES

Номер: US20210009816A1
Автор: Andes Keith J., Boudreaux Matthew F., Devonport Wayne, Liu Lily
Принадлежит:

Latex emulsions and a process of making the same that incorporates voided latex particles having a core with a hydrophilic component; at least one intermediate shell with, as polymerized units, one or more hydrophilic monoethylenically unsaturated monomer, one or more nonionic monoethylenically unsaturated monomer, or mixtures thereof; an outer shell formed of a polymer having a Tg of at least 60? C; and a surface treatment applied to the outer shell in which a plurality of silicone oligomers with reactive functional groups are cross-linked with one another in order to provide a cross-linked outer surface. The core and the at least one intermediate shell are contacted with a swelling agent in the presence of less than 0.5% monomer based on the overall weight of the voided latex particles. In addition, one or more of the core, the intermediate shell, or the outer shell includes a surfactant. 1. Hollow or voided latex particles comprising:a core comprising a hydrophilic component;at least one intermediate layer comprising, as polymerized units, one or more hydrophilic monoetheylenically unsaturated monomer, one or more nonionic monoethylenically unsaturated monomer, or mixtures thereof;{'sub': 'g', 'an outer shell comprising a polymer having a Tof at least 60° C.; and'}a surface treatment applied to the outer shell comprising a plurality of silicone monomers, oligomers and/or polymers having polymerizable or cross-linkable functional groups, the functional groups being cross-linked with one another in order to provide a cross-linked outer surface;wherein the core and the at least one intermediate layer are contacted with a swelling agent in the presence of less than 0.5% monomer based on the overall weight of the voided latex particles,wherein one or more of the core, the intermediate layer, or the outer shell includes sodium dodecylbenzene sulfonate, and optionally other surfactants.2. The hollow or voided particles of claim 1 , wherein the particles further comprise ...

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Номер записи: 98
10-01-2019 дата публикации

COMPOSITION, METHOD OF MAKING COMPOSITION, AND ARTICLE

Номер: US20190010341A1
Автор: Jiang Xuan, Jing Naiyong, Liu Jiafeng, Wu Shupeng, Xiong Mingna, Yu Zhigang
Принадлежит:

A composition having pH of 5 or less comprises composite particles dispersed in an aqueous continuous liquid phase. Each composite particle comprises a polymer core surrounded by a silicaceous shell. From 3 to 50 percent of silicon atoms in the silicaceous shells are bonded to respective organic groups via a silicon-carbon covalent bond. The weight ratio of the total amount of the silica in the composition to the total amount of the at least one polymer is from 0.1 to 19. The composition is useful for making various articles. A method for making the composition is also disclosed. Silicaceous particles dispersed in an aqueous phase, wherein from 3 to 50 percent of silicon atoms in the silicaceous particles are bonded to organic groups via a silicon-carbon covalent bond are also disclosed. 120-. (canceled)21. A composition comprising:an aqueous continuous liquid phase; a polymer core comprising at least one polymer,', 'a silicaceous shell surrounding and disposed on the polymer core, wherein from 3 to 50 percent of silicon atoms in the silicaceous shell are bonded to respective organic groups via a silicon-carbon covalent bond, and wherein the weight ratio of a total amount of the silica in the composition to the total amount of the at least one polymer is from 0.1 to 19, and, 'composite particles dispersed in the aqueous continuous liquid phase, each composite particle comprisingwherein the composition has a pH of 5 or less.22. The composition of claim 21 , wherein the organic groups comprise at least one of an alkyl group having from 1 to 4 carbon atoms claim 21 , a chloromethyl group claim 21 , an epoxyalkyl group having from 1 to 6 carbon atoms claim 21 , an epoxyalkyleneoxyalkyl group having from 1 to 6 carbon atoms claim 21 , an alkenyl group having from 1 to 6 carbon atoms claim 21 , and a combination thereof.23. The composition of claim 21 , wherein the composition further comprises a water-soluble polymer.24. The composition of claim 21 , wherein the water- ...

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Номер записи: 99
10-01-2019 дата публикации

ORGANIC RARE EARTH SOLID MICELLE, PREPARATION METHOD THEREFOR, AND METHOD FOR INCREASING PHOTOELECTRIC CONVERSION EFFICIENCY OF SOLAR BATTERY

Номер: US20190010389A1
Автор: Belfiore Laurence A., Bu Fanchen, HUANG Linjun, Jiao Jiqing, Liu Jixian, Shen Wenfei, Song Yan, TANG Jianguo, Wang Die, Wang Jing, Wang Wei, Wang Xinzhi, Wang Yanxin, WANG YAO, Xu Xingqin, Yang Huihui, Zhang Xiaolin
Принадлежит: QINGDAO UNIVERSITY

Provided are an organic rare-earth solid micelle, a preparation method therefor, and a method for increasing the photoelectric conversion efficiency of a solar battery. A small organic conjugated ligand is taken as a first ligand, an amphiphilic diblock polymer is taken as a second ligand, and the first ligand and the second ligand are mixed and doped with a rare-earth chloride solution, and self-assembled to form an organic rare-earth solid micelle, whereby the fluorescence emission intensity and the fluorescence efficiency of the rare-earth element are improved. Next, the prepared organic rare-earth solid micelle is spin coated on an ITO layer of a solar battery, to prepare a solar battery with the organic rare-earth solid micelle. Therefore the sunlight absorption of a cell is increased, and the photoelectric conversion efficiency is improved. The preparation process is simple, low in cost, high in photoelectric conversion efficiency, and environmentally friendly. 1. A method for preparing an organic rare-earth solid micelle , comprising: taking a small organic conjugated ligand as a first ligand and an amphiphilic diblock polymer as a second ligand , mixing and doping the first ligand and the second ligand with a rare-earth chloride solution , and self-assembling to form an organic rare-earth solid micelle;wherein the amphiphilic diblock polymer is polymethyl methacrylate-b-polyacrylic acid (PMMA-b-PAA),the molar ratio of the small organic conjugated ligand:rare-earth chloride:amphiphilic diblock polymer is 3:1:1,wherein the small organic conjugated ligand:rare-earth chloride:amphiphilic diblock polymer are subjected to complexation reaction for 5-10 hrs in an oil bath at 50-70° C., to obtain a solution of an organic rare-earth solid micelle that is a complex having a size of 10-20 nm.2. (canceled)3. The preparation method according to claim 1 , wherein the polymethyl methacrylate-b-polyacrylic acid (PMMA-b-PAA) useful as the amphiphilic diblock polymer is ...

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Номер записи: 100