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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 6385. Отображено 100.
01-08-2019 дата публикации

Вертикальная центрифуга

Номер: RU0000191345U1

Предлагаемое техническое решение относится к области очистки в фильтрующих центрифугах и может найти применение в химической, нефтехимической, атомной, микробиологической, а также в экологических процессах очистки сточных вод.Техническим результатом является повышение производительности.Поставленный технический результат достигается тем, что в вертикальной центрифуге, состоящей из цилиндрического барабана, снабженного ситом и закрепленного на валу, соединенном с приводным двигателем, закрепленным на раме, и снабженной вибратором, отличается тем, что на раме закреплены штанги, на котрых осесимметрично с валом центрифуги закреплен диск, имеющий форму эллипса, а на днище цилиндрического барабана в плоскости диска закреплено кольцо, имеющее также форму эллипса, при этом длина большой оси эллипса диска и длина малой оси эллипса кольца подчиняются соотношению:где d - длина большой оси эллипса диска, мм;D - длина малой оси эллипса кольца, мм. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 191 345 U1 (51) МПК B04B 3/00 (2006.01) B04B 5/12 (2006.01) B04B 7/08 (2006.01) B04B 9/02 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК B04B 3/00 (2019.05); B04B 5/005 (2019.05); B04B 7/00 (2019.05) (21)(22) Заявка: 2019105895, 01.03.2019 (24) Дата начала отсчета срока действия патента: Дата регистрации: 01.08.2019 (45) Опубликовано: 01.08.2019 Бюл. № 22 1 9 1 3 4 5 R U (54) ВЕРТИКАЛЬНАЯ ЦЕНТРИФУГА (57) Реферат: Предлагаемое техническое решение относится к области очистки в фильтрующих центрифугах и может найти применение в химической, нефтехимической, атомной, микробиологической, а также в экологических процессах очистки сточных вод. Техническим результатом является повышение производительности. Поставленный технический результат достигается тем, что в вертикальной центрифуге, состоящей из цилиндрического барабана, снабженного ситом и закрепленного на валу, соединенном с приводным двигателем, закрепленным на раме, и снабженной Стр ...

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19-01-2012 дата публикации

Method for Optimizing Spin Time In a Centrifuge Apparatus for Biologic Fluid

Номер: US20120015794A1
Принадлежит: Terumo BCT Inc

A method for controlling a centrifuge blood component separation system for separating components of a blood product, the separation system comprising a centrifuge and a separation bag and at least one transfer bag. The method comprises selecting a nominal hematocrit value such that an actual hematocrit value is expected to be less than said nominal hematocrit; centrifuging a separation bag containing a volume of composite liquid so as to cause the sedimentation of at least a first component and a second component; transferring some of the first component to a first transfer bag; detecting time of passage of a red blood cell interface at a pre-selected location in the separation bag; and adjusting a predicted processing time based on the time of passage of the red blood cell interface.

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15-03-2012 дата публикации

Centrifuge and separation vessel therefore

Номер: US20120065047A1
Принадлежит: Chapman John R, Coelho Philip H, Rodney Sparks

The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.

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14-06-2012 дата публикации

Integrated disposable set for an apheresis system

Номер: US20120145619A1
Принадлежит: Terumo BCT Inc

An integrated pre-connected apheresis disposable set for separating plasma from blood in a separation vessel and further separating the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma.

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21-06-2012 дата публикации

Self cleaning fan assembly

Номер: US20120151886A1
Принадлежит: Microsoft Corp

This patent pertains to self-cleaning fan assemblies. One implementation includes electronic components positioned in an enclosure. This implementation also includes a fan assembly that is configured to impart rotational force on air to move the air from outside the enclosure to inside the enclosure and around the electronic components. The fan assembly is further configured to separate contaminants from the air based upon differences in density between the contaminants and the air.

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26-07-2012 дата публикации

Swing rotor for centrifugal separator and centrifugal separator

Номер: US20120190527A1
Автор: Kenichi Nemoto
Принадлежит: HITACHI KOKI CO LTD

A swing rotor for a centrifugal separator, the swing rotor including: a hub; and a rotor body disposed around the hub, wherein a plurality of pairs of arms are disposed at the rotor body, wherein a holding pin configured to hold a bucket is disposed to the arm, wherein an engagement portion which is configured to be supported by the holding pin is formed to the bucket, and wherein a sliding surface of the holding pin with an engagement portion of the bucket is formed such that a width of a contact area, which is an area that the holding pin contacts with the engagement portion of the bucket, in an axial direction when the bucket does not swing differs from a width of the contact area in the axial direction when the bucket reaches a horizontal position by swinging during a centrifugal separation operation.

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13-12-2012 дата публикации

System for Blood Separation with Side-Tapped Separation Chamber

Номер: US20120316051A1
Автор: Brian M. Holmes
Принадлежит: Terumo BCT Inc

A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, and outlet and a side tap outlet adjacent the inlet. The inlet may protrude into the cell separation chamber forming a circumferential well surrounding the protruding inlet. The side tap outlet may connect to the well. The set and system comprise means for selectively drawing fluid from either the outlet or the side tap outlet.

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07-02-2013 дата публикации

System and Method for the Continuous Extraction of a Liquid Phase of Microsamples, and Automated Installation for Taking Them, For Carrying Out the Extraction and Taking Measurements

Номер: US20130035223A1

A continuous automated extraction system and method for physically extracting at least one liquid phase of a series of liquid microsamples which are taken beforehand in discrete packets, both in space and in time, and are in stored is provided. The method may include an extraction system having a centrifuge provided with a plurality of microholders, at least one of which is filled with the corresponding microsample and includes a filling upper portion that is extended by a separating lower portion of smaller cross section than that of the upper portion. Each filled microholder has a mass which is more than ten times the mass of this microsample, in such a way that it is possible to extract, by centrifugation, at a given instant, only a single microsample contained in a single microholder, or several microsamples contained in some or all of these microholders, progressively as the latter are filled.

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21-03-2013 дата публикации

CENTRIFUGAL SEPARATOR

Номер: US20130067873A1
Принадлежит: ALFA LAVAL CORPORATE AB

A device for cleaning of polluted gas from a combustion engine, includes a centrifugal separator with a centrifuge rotor arranged to cause the polluted gas to rotate. The centrifuge rotor comprises a stack of truncated conical separating discs disposed at mutual spacing so they delimit intermediate spaces between them for the gas to flow through. An outlet chamber is disposed centrally within the stack of separating discs, whereby the centrifuge rotor is configured for counterflow separation. The centrifugal separator comprises a gas outlet which communicates with the outlet chamber. The stack of separating discs is disposed for rotation in a space formed within the combustion engine and arranged to receive the polluted gas, to which end the intermediate spaces between the separating discs communicate directly with the space, and the gas outlet is arranged to conduct the cleaned gas out from the space through a wall which delimits the space. 120-. (canceled)21. A device for cleaning of polluted gas at a combustion engine , which device comprises a centrifugal separator for cleaning of the gas from therein suspended pollutants in the form of solid or liquid particles , which centrifugal separator comprisesa centrifuge rotor which is rotatable about a rotational axis by a drive device and is arranged to cause the gas to rotate, wherein the centrifuge rotor comprises a stack of truncated conical separating discs disposed at mutual spacing so that they delimit intermediate spaces between them for the gas to flow through,an outlet chamber which is disposed centrally within the stack of separating discs and communicates with said intermediate spaces, whereby the centrifuge rotor is configured for counterflow separation in such a way that the polluted gas is caused to rotate and is led into the intermediate spaces radially from outside the stack of separating discs and into towards the central outlet chamber, anda gas outlet which communicates with the outlet chamber and ...

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04-04-2013 дата публикации

Water Extraction Using a Directional Solvent

Номер: US20130082003A1
Принадлежит: Massachusetts Institute of Technology

Purified water can be obtained via a continuous or semi-continuous process by mixing a liquid composition (e.g., sea water or produced frac water) including water with a directional solvent to selectively dissolve water from the liquid composition into the directional solvent. The concentrated remainder of the liquid composition (e.g., brine) is removed, and the water is precipitated from the directional solvent and removed in a purified form. The solvent is then reused as the process is repeated in a continuous or semi-continuous operation.

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16-05-2013 дата публикации

Air Extraction Device and Method for Removing Particles Carried by an Air Stream

Номер: US20130118352A1
Автор: Berling Udo
Принадлежит: BERLING GMBH

The invention relates to an air extraction device () comprising an intake opening (), a downstream air duct for an air flow (L), said air duct extending in a first section through a rotatingly driven fan wheel () radially outward and extending in a second section downstream of the outlet openings () of the fan wheel () such that the air flow (L) is deviated in an approximately axial direction to the fan wheel (), and runs into an exhaust opening (). The second section has a lateral wall () that is arranged opposite to the outlet openings () of the fan wheel () at a distance thereto. The aim of the invention is to improve the capacity of the air extraction device. For this purpose, the second section comprises a through-flow compartment () arranged in the plane of rotation of the fan wheel () which compartment is arranged downstream of the outlet openings () of the fan wheel (), which is radially limited by the lateral wall () and in which no air guideways are arranged. 116-. (canceled)17. An air extraction device comprising:an intake opening;a blow-out opening;an air guiding passage adapted to guide an air flow in a flow direction from the intake opening to the blow-out opening;a rotatingly drivable fan wheel having outflow openings;wherein the air guiding passage comprises a first section and a second section;wherein the first section adjoins the intake opening and extends through the fan wheel in a radial direction outwardly;wherein the second section adjoins the outflow openings of the fan wheel and causes a deflection of the air flow in an approximately axial direction relative to the fan wheel and ends at the blow-out opening;wherein the second section has a lateral wall positioned at a spacing opposite to the outflow openings of the fan wheel;wherein the second section comprises a flow-through space that is arranged in a rotational plane of the fan wheel adjacent to the outflow openings of the fan wheel;wherein the flow-through space is delimited in the radial ...

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16-05-2013 дата публикации

Centrifugal separator having a particle guide trough

Номер: US20130123090A1
Автор: Dirk Hornung
Принадлежит: Individual

A centrifugal separator for separating non-gaseous particles from a gas flow having a separator housing enclosing a rotor with a raw gas inlet, a clean gas outlet, and a particle outlet. A circumferential wall encloses the rotor. A raw gas flow is guided axially into the rotor. A clean gas flow is guided out of the rotor and then between the rotor and the circumferential wall to the clean gas outlet. The rotor comprises particle separation elements so that particles separated from the gas flow are centrifuged onto the circumferential wall. The circumferential wall particles are guided to the particle outlet via at least one particle guide trough running diagonal to the rotor axial direction on the interior of the circumferential wall. A radius of each trough as well as the distance between the rotor and the circumferential wall decreases in the direction of the clean gas flow.

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30-05-2013 дата публикации

APPARATUS AND METHOD FOR GAS SEPARATION

Номер: US20130133514A1
Принадлежит: H R D Corporation

Herein disclosed is an apparatus that includes a porous rotor positioned about an axis of rotation and surrounding an interior space wherein the porous rotor comprises sintered metal or ceramic; an outer casing, wherein the outer casing and the porous rotor are separated by an annular space; and a motor configured for rotating the porous rotor about the axis of rotation. 19-. (canceled)10. A method of separating a feed gas into a first fraction and a second fraction , the method comprising:introducing the feed gas into an interior space within a rotor of a gas centrifuge, wherein the rotor is permeable to gas and positioned about an axis of rotation;rotating the rotor about the axis of rotation, whereby heavy molecules of the feed gas are forced toward the rotor; andextracting at least some of the first fraction from within the interior space through a sintered metal tube, and also extracting at least some of the second fraction from within the interior space, wherein the first fraction has an average molecular weight lower than the average molecular weight of the second fraction.11. (canceled)12. The method of claim 10 , wherein extracting the second fraction from the interior space comprises passing the second fraction through the rotor.13. The method of claim 10 , the method further comprising assisting extraction of the first fraction via application of vacuum.14. The method of claim 13 , wherein rotating the rotor about the axis of rotation provides a rotational frequency of at least 7 claim 13 ,500 RPM.15. (canceled)16. The method of claim 10 , wherein the sintered metal tube has an average pore size exclusive of particles above a cutpoint size.17. The method of claim 16 , wherein the rotor comprises a porous rotor claim 16 , and wherein the porous rotor is positioned symmetrically about the axis of rotation.18. A method of separating a feed gas into a first fraction and a second fraction claim 16 , the method comprising:introducing the feed gas into an ...

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11-07-2013 дата публикации

APPARATUS FOR CENTRIFUGAL SEPARATION OF SOLID AND/OR LIQUID PARTICLES FROM A FLOW OF GAS

Номер: US20130174524A1
Автор: Franzén Peter, Inge Claes
Принадлежит:

Apparatus for centrifugal separation of solid and/or liquid particles from a flow of gas, wherein two or more rotors () provided with conical separation surface elements () are located in a surrounding stationary casing (), which delimits a common chamber () for collecting particles separated in the rotors. Each rotor has a fan () rotating together therewith. The fans () of the rotors are located in a common fan housing () that is separate from and adjacent to the casing () defining the collection chamber (). 1. An apparatus for centrifugal separation of solid and/or liquid particles from a flow of gas , where two or more rotors are arranged in a surrounding , stationary casing , which delimits a common collection chamber for particles separated in the rotors and in which the rotors are rotatably mounted , said casing having at least one inlet for the flow of gas to be cleaned from particles , and at least one particle outlet for the discharge of particles separated and collected in the casing , wherein each rotor has a plurality of adjacent conical surface elements with an inside facing the rotor axis and on which the particles in the gas flow can be trapped by centrifugal forces during the radial passage inwardly of the gas through flow gaps between the surface elements , said surface elements of each rotor delimits at least one axial outlet shaft in the central part of the rotor which communicates with the flow gaps between the surface elements and from which cleaned gas can be discharged out of the casing by means of a fan rotating together with each rotor for generating the flow of gas through the apparatus , said fan being located adjacent to an outlet end of the shaft , and all fans of the rotors being arranged in a common fan housing that is separate from and adjacent to the casing defining the collection chamber for a common discharge of cleaned gas from the rotors.2. The apparatus according to claim 1 , wherein each fan is provided with a respective helix ...

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25-07-2013 дата публикации

BLOOD SEPARATION AND CONCENTRATION SYSTEM

Номер: US20130189668A1
Принадлежит: Biomet Biologics, LLC

This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator. 1. A disposable set comprising a separation disc , a concentrator and a second conduit , wherein the second conduit provides a fluid connection between the separation disc and the concentrator.2. The disposable set of claim 1 , further comprising a first conduit and one or more cassettes claim 1 , which cassettes comprise the first conduit and/or the second conduit claim 1 , which cassettes guidedly mount to system components claim 1 , thereby providing operative mounting of the disposable set to the system components.3. The disposable set of claim 2 , wherein the system components comprise one or more valves claim 2 , one or more detectors claim 2 , and/or more pumps.4. The disposable set of claim 2 , wherein the disposable set is manufactured from plastic.5. The disposable set of claim 2 , wherein the disposable set is sterilized by gamma radiation.6. The disposable set of claim 6 , further comprising a sealed container which encloses the disposable set.759-. (canceled)60. The concentrated blood components of claim 88 , wherein the concentrated blood components comprise one or more growth factors present at a level 2-fold or more over peripheral blood levels.61. The concentrated blood components of claim 60 , wherein the growth factors are selected from the list consisting of EGF claim 60 , IGF claim 60 , PDGF claim 60 , TGF claim 60 , VEGF and FGF.62. The concentrated blood components of claim 60 , wherein the growth factor is EGF at a concentration of more than 100 pg per ml.63. The concentrated blood components of claim 60 , wherein the growth factor is FGF at a concentration of more than 150 pg per ml.64. The concentrated blood components of claim 60 , wherein the growth factor ...

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01-08-2013 дата публикации

Adaptable Perioperative Cell-Salvage System and Methods and Disposable Units for Same

Номер: US20130197470A1
Автор: Bobroff Alec D.
Принадлежит: Haemonetics Corporation

A blood-collection system configured to permit selection of either collection and disposal of shed blood from a patient or collection and processing of shed blood for autologous transfusion back to the patient includes an automated blood-processing machine. The system may also include a blood-collection reservoir, a separation chamber, and a fluid conduit. The blood-collection reservoir may be engageable with the blood-processing machine so that the machine can identify and report the presence of blood in the reservoir. The separation chamber may also be engageable with the blood processing machine. The fluid conduit may be configured to selectively join the reservoir to the separation chamber by a quick-connect coupling. 2. A method according to claim 1 , further comprising attaching the reservoir to an automated base unit.3. A method according to claim 2 , further comprising:installing a dummy disk into the base unit prior to removing the second disposable set from its hermetically sealed package.4. A method according to claim 3 , wherein the dummy disk allows the automated base unit to operate in a collection mode.5. A method according to claim 4 , further comprising:removing the dummy disk from the base unit if the volume of shed blood reaches the threshold; andinstalling the separation chamber into the base unit.6. A method according to claim 2 , further including installing the separation chamber in the base unit.7. A method according to claim 1 , further including autotransfusing the blood component into a patient.8. A method according to claim 1 , further comprising:connecting a vacuum port on the reservoir to a vacuum source.9. A method according to claim 1 , further comprising:extracting the separated blood component from the separation chamber; andcollecting the separated blood component in a blood-component container, wherein the blood-component container is stored in the same hermetically sealed package as the separation chamber.10. A method according ...

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29-08-2013 дата публикации

DEVICE TO REMOVE PARTICLES FROM A GAS STREAM

Номер: US20130219843A1
Автор: Barker Mario J. C.

A device to separate particles from a gas stream. The device may be a vacuum cleaner () or an industrial dust extraction device. The vacuum cleaner () includes a rotor assembly () to which the gas stream is delivered, the rotor assembly () having a plurality of gates () that collect dust and open to deliver dust to an outlet chamber (). The gates () include Cone or more gates () that may include a resilient deflectable flange that is movable between an open and a closed position to provide for passage of the dust to the chamber (). 110-. (canceled)11. A device to separate particles from a gas stream , the device including:a chamber having an inlet and an outlet between which the gas stream flows;a rotor mounted in the chamber for rotation about a rotation axis, the rotor including a longitudinal passage extending through the rotor along which the gas stream passes in moving from the inlet to the outlet of the chamber;a plurality of gates located radially outward of the passage which collect the particles from the gas stream passing through the passage, each of the gates being operable to move between a closed position for collecting the particles at the gate, and an open position providing for delivery of the collected particles from the gate; anda cavity into which the particles are delivered from the plurality of gates.12. The device of claim 11 , wherein each gate includes an upstream gate portion and a downstream gate portion claim 11 , with the upstream gate portion being operable in an open position and a closed position claim 11 , with the upstream gate portion in the open position providing for the flow of particles to the downstream gate portion claim 11 , with the downstream gate portion being operable in an open position and a closed position claim 11 , with the downstream gate portion in the open position providing for the delivery of particles to the cavity.13. The device of claim 12 , wherein particles collect between the upstream gate portion in the ...

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29-08-2013 дата публикации

METHODS FOR SEPARATING CONSTITUENTS OF BIOLOGIC LIQUID MIXTURES

Номер: US20130226150A1
Принадлежит:

Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other factors. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants. 127-. (canceled)28. A centrifuge for selectively concentrating and collecting constituents of a biologic liquid mixture , said constituents having differing specific gravities and being stratifiable in a centrifugal field produced by said centrifuge , said centrifuge comprising:a) a chamber arranged to contain a liquid mixture and having a central longitudinal axis about which said chamber is arranged to be rotated to produce said centrifugal field, said chamber comprising:(i) an assembly comprising a tubular barrel and an end wall, each comprising a common central longitudinal axis, said tubular barrel comprising a side wall tapering radially inward toward said central longitudinal axis from said end wall;(ii) an inlet for adding the liquid mixture to said chamber;(iii) a first port in fluid communication with said chamber and located in said assembly at a first radial distance from said central longitudinal axis; and(iv) a second port in fluid communication with said chamber and located in said assembly at a second radial distance from said central longitudinal axis, said second radial distance being smaller than said first radial distance;b) a motor to rotate said chamber about said central longitudinal axis to produce said centrifugal field, whereupon ...

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26-09-2013 дата публикации

UMBILICUS FOR USE IN AN UMBILICUS-DRIVEN FLUID PROCESSING SYSTEM

Номер: US20130248040A1
Принадлежит: Fenwal, Inc.

An umbilicus is provided for use in an umbilicus-driven fluid processing system. The umbilicus has a pair of anchor portions, at least one fluid-transmitting lumen, and a drive shaft. The fluid-transmitting lumen and drive shaft extend between the anchor portions. The lumen and drive shaft may be comprised of different materials. If multiple lumen are provided, they may either be separate from each other and the drive shaft or defined in a single umbilicus body which also provides a lumen for receiving at least a portion of the drive shaft. 17-. (canceled)8. An umbilicus for use in an umbilicus-driven fluid processing system , comprising:an elongated, single-piece umbilicus body having enlarged ends and defining a plurality of lumen; and 'one of said lumen receives at least a portion of the drive shaft and at least one other of said lumen is adapted for transmitting a fluid between the enlarged ends of the umbilicus body.', 'an elongated, flexible, non-fluid-transmitting drive shaft extending between the enlarged ends of the umbilicus body, wherein'}9. The umbilicus of claim 8 , wherein the drive shaft comprises a single filament.10. The umbilicus of claim 8 , wherein the drive shaft comprises a plurality of filaments.11. (canceled)12. The umbilicus of claim 8 , wherein the fluid-transmitting lumen has a larger cross-sectional area at the enlarged ends of the umbilicus body than therebetween.13. The umbilicus of claim 8 , wherein the lumen receiving the drive shaft is substantially coaxial with a central axis of the umbilicus body.14. The umbilicus of claim 13 , wherein the umbilicus body defines a plurality of fluid-transmitting lumen symmetrically positioned around the central axis of the umbilicus body.1520-. (canceled)21. The umbilicus of claim 8 , wherein the fluid-transmitting lumen has a different cross-sectional shape at the enlarged ends of the umbilicus body and at a position between the enlarged ends.22. The umbilicus of claim 8 , wherein the fluid- ...

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26-09-2013 дата публикации

Device for insertion into a rotor of a centrifuge, centrifuge and method for the fluidic coupling of cavities

Номер: US20130252796A1

A device for insertion into a rotor of a centrifuge has at least two bodies stacked one above the other in a stacking direction inside a housing. The housing is configured such that it can be inserted into a holder of the rotor of the centrifuge. With a correct reception of the device in the centrifuge, and upon a rotation of the rotor, a spacing of one of the at least two bodies in relation to the axis of rotation of the rotor is smaller than a spacing of another of the at least two bodies in relation to the axis of rotation of the rotor. A first of the at least two bodies has at least one first cavity and a second cavity and a second body of the at least two bodies has at least one first cavity. The two bodies are movably disposed in relation to each other inside the housing in order to fluidically couple, in a first phase, responding to a rotation of the rotor, the first cavity of the first body to the first cavity of the second body and to fluidically couple in a second phase the second cavity of the first body to the first cavity of the second body.

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03-10-2013 дата публикации

Device, Method, and System to Separate Liquid and Particulate Matter from the Airstream of a Centrifugal Fan

Номер: US20130255497A1
Принадлежит: Leseman Davis, LLC

A system for separating contaminants from an airstream, including a centrifugal fan and housing; a contaminant containment vessel mounted to an outer surface of the housing; and a diverter in the airstream downstream of the fan and within the housing, the diverter being configured to separate a portion of the airstream from a remainder of the airstream, accelerate the portion of the airstream towards the containment vessel, and thereafter guide the portion of the airstream towards the remainder of the airstream. The diverter preferably does not negatively impact the rated performance of the fan, such that a performance of the system is not measurably different than the rated performance of the fan and housing combination. The diverter may accelerate contaminants entrained in the airstream toward the containment vessel, thereby separating the contaminants from the airstream. 1. A system for separating contaminants from an airstream , the system comprising:a centrifugal fan housing;a centrifugal fan disposed within the housing and configured to provide an airstream;a contaminant containment vessel; anda diverter in the airstream, the diverter being configured to separate a portion of the airstream from a remainder of the airstream, accelerate the portion of the airstream towards the containment vessel, and thereafter guide the portion of the airstream towards the remainder of the airstream.2. The system as set forth in claim 1 , wherein the diverter is configured to not negatively impact a rated performance of the fan within the housing claim 1 , such that a performance of the system is not measurably different than the rated performance of the fan within the housing.3. The system as set forth in claim 1 , wherein the diverter is further configured to accelerate contaminants entrained in the airstream toward the containment vessel claim 1 , thereby separating the contaminants from the airstream.4. The system as set forth in claim 1 , wherein the containment vessel and ...

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10-10-2013 дата публикации

System and Method For Collecting And Treating Plasma Protein Fractions

Номер: US20130264288A1
Принадлежит: Terumo BCT Inc

Method and apparatus for separating plasma from blood in a separation vessel, separating the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma, and adding photosensitizer to the desired plasma proteins for viral inactivation treatment of such proteins.

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31-10-2013 дата публикации

Centrifuge for separating of whole blood into blood components as well as fluidically communicating containers for insertion into the centrifuge, as well as a method for obtaining a highly enriched thrombocyte concentrate out of whole blood

Номер: US20130288874A1
Автор: Klaus-Günter EBERLE
Принадлежит: Andreas Hettich GmbH and Co KG

The invention refers to a centrifuge for separating whole blood into its blood components and a method for extracting a highly enriched thrombocyte concentrate out of whole blood. For this purpose, the centrifuge comprises a closed loop and/or open-loop control unit as well as a drive unit coupled to the closed loop and/or open-loop control unit, a rotor ( 12 ) having at least two container receptacles ( 14 a, 14 b; 16 a, 16 ) for removably holding containers ( 18, 20, 22, 24 ) being in fluid communication with each other, at least one sensor arranged between the container receptacles ( 14 a, 14 b; 16 a, 16 b) and coupled with the closed loop and/or open-loop control unit for detecting a separation layer. Herein, a motor/gear unit ( 30 a, 30 b, 32 a, 32 b ) coupled to the closed loop and/or open-loop control unit is associated with each of the container receptacles ( 14 a, 14 b; 16 a, 16 b ). Each of the motor/gear unit units is in operational contact through means ( 34 ) with each of the containers ( 18, 20, 22, 24 ) supported in the respective container receptacle ( 14 a, 14 b; 16 a, 16 b ) such that a transfer and back-transfer of blood components between the containers ( 18, 20, 22, 24 ) is initiated.

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07-11-2013 дата публикации

Methods And Apparatus For Isolating Platelets From Blood

Номер: US20130294983A1
Принадлежит:

A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield. 1. A blood platelet collection device , comprising:a container that partially defines a volume by a sidewall extending from a first end to a second end;a float positioned in the volume, the float having a collection surface;a closure at the first end of the container;a first access port formed through the closure; anda second access port formed through the closure;wherein blood is introduced into the container through the first access port and wherein sedimented platelets are withdrawn through the second access port.2. The blood platelet collection device of claim 1 , wherein the second end of the container is closed.3. The blood platelet collection device of claim 1 , further comprising:a vent for venting the container to an exterior of the container, wherein the vent, first access port, and second access port are formed through the closure.4. The blood platelet collection device of claim 3 , wherein the closure is a cap of the container.5. The blood platelet collection device of claim 1 , wherein the float further includes a base having an outer surface claim 1 , where the collection surface is a platelet collection surface that is above the base and the float has a density less than a density of erythrocytes and greater than a ...

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05-12-2013 дата публикации

METHOD AND DEVICE FOR SEPARATING AND TRANSFERRING CONTAINER CONTENTS BY DYNAMICAL USE OF CENTRIFUGE FORCE

Номер: US20130324388A1
Принадлежит: ISENS - ELECTRONICA, LDA.

The present invention relates to a method and device for separating and transferring container () contents by dynamical use of centrifuge force, transferring a specific volume of liquid (A) from a recipient () to another () without contact with any external element other than the initial container () itself. Therefore, the present invention is useful for transferring for example part of a blood sample (A) from a tube () without touching the blood sample, also dispensing with a disposable needle as is currently usual. The invention is also advantageous as it allows keeping in the original container () a predetermined portion of the sample (B). By rotating the container, with a sufficiently high speed, over an axis (x) located at the boundary of the parts (A, B), the sample is split at a predetermined position. A preferred embodiment comprises the container at an angle (V) to the rotation axis (x). 11. A centrifugal device for separating or transferring container contents comprising a rotation axis (x) suitable for applying a centrifugal force (F) to extract part (A) or whole (A , B) of the container () contents.2. The device according to for separating container contents claim 1 , wherein the rotation axis (x) location is substantially aligned with the boundary of the content parts (A claim 1 , B) to be separated.311. The device according to claim 1 , wherein the rotation axis location (x) is substantially aligned with the innermost part of the container () or further distanced from both the innermost part and opening part of the container ().41. The device according to further comprising a holder (P) to place the container () at an angle (V) claim 1 , in respect of the axis of its opening part and the rotation axis (x).521. The device according to further comprising a holder (P) to place the secondary container () at an angle claim 4 , in respect of the axis of its opening part and the rotation axis (x) claim 4 , with its opening substantially directed towards the ...

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12-12-2013 дата публикации

Apheresis Bowl with Improved Vibration Characteristics

Номер: US20130331252A1
Принадлежит: Haemonetics Corporation

A centrifuge bowl for separating whole blood into blood components includes a rotatable body, and inlet, and a plurality of vibration reduction members. The rotatable body has a body portion and a neck portion. The body portion defines an interior for receiving whole blood, and the body is rotatable to separate the whole blood into a plurality of blood components. The inlet is in fluid communication with the interior of the rotatable body, and is configured to introduce the whole blood into the rotatable body. The plurality of vibration reduction members are spaced about the neck portion, and are configured to reduce vibration of the centrifuge bowl as the bowl is rotated. 1. A centrifuge bowl for separating whole blood into blood components comprising:a rotatable body having a body portion and a neck portion, the body portion defining an interior for receiving whole blood, the body being rotatable to separate the whole blood into a plurality of blood components;an inlet in fluid communication with the interior of the rotatable body, the inlet configured to introduce the whole blood into the rotatable body; anda plurality of vibration reduction members spaced about the neck portion, the vibration reduction members configured to reduce vibration of the centrifuge bowl as the bowl is rotated.2. A centrifuge bowl according to claim 1 , wherein the plurality of vibration reduction members are radially spaced about the neck portion.3. A centrifuge bowl according to claim 1 , wherein the plurality of vibration reduction members are rib members.4. A centrifuge bowl according to claim 3 , wherein the rib members are curved.5. A centrifuge bowl according to claim 3 , wherein the rib members are straight.6. A centrifuge bowl according to further comprising an outlet claim 1 , the outlet in fluid communication with the interior of the bowl and configured to remove one or more of the blood components from the centrifuge bowl.7. A centrifuge bowl according to further comprising ...

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06-02-2014 дата публикации

Drive system for centrifuge

Номер: US20140038760A1
Принадлежит: Fenwal Inc

A drive assembly for a centrifugal processing system is provided for rotating the yoke assembly (36) about a first axis at a first angular ve locity and rotating the chamber assembly (30) coaxially with the yoke assembly at a second angular velocity A drive motor (54) is provided for rotating the yoke assembly at the first angular velocity and simul taneously rotating the chamber assembly at the second angular ve locity by means of a sun gear (66) mounted to the chamber assembly for rotation about the first axis and a planetary gear (64) mounted to the yoke assembly that is operatively connected to the sun gear such as to impart rotation to the sun gear as it orbits thereabout upon rota

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06-02-2014 дата публикации

System and Method for Automated Separation of Whole Blood

Номер: US20140039373A1
Принадлежит: Haemonetics Corporation

An apparatus for separating whole blood includes an access device for drawing whole blood from a source, a blood component separation device, a draw line, a draw pump, and a controller. The blood component separation device separates the drawn whole blood into a first blood component and a second blood component. The draw line fluidly connects the access device and the blood component separation device, and the draw pump draws whole blood from the source through the access device and draw line and into the blood component separation device. The controller controls fluid flow through the apparatus and operation of the draw pump. The controller also monitors the total volume of whole blood drawn from the source and the total volume of first blood component collected. The controller stops the draw pump when the first of a target whole blood volume is withdrawn or a target volume of first blood component is collected. 1. An apparatus for separating whole blood comprising:an access device through which whole blood is drawn from a source;a blood component separation device in which the drawn whole blood is separated into a first blood component and a second blood component;a draw line fluidly connecting the venous access device and the blood component separation device;a draw pump that draws whole blood from the source through the access device and draw line and into the blood component separation device;a controller for controlling fluid flow through the apparatus, the controller controlling operation of the draw pump and monitoring a total volume of whole blood drawn from the source and a total volume of first blood component collected, the controller configured to stop the draw pump when the first of a target whole blood volume is withdrawn or a target volume of first blood component is collected.2. An apparatus according to further comprising:an optical sensor configured to monitor fluid flowing out of the blood component separation device and output a signal ...

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13-02-2014 дата публикации

METHODS FOR SEPARATING CONSTITUENTS OF BIOLOGIC LIQUID MIXTURES

Номер: US20140044688A1
Принадлежит: KENSEY NASH CORPORATION

Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other facts. Highs speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants. 1. A method for selectively concentrating and collecting constituents of a biologic liquid mixture selected from the group consisting of blood , tissue or tissue components , said constituents having differing specific gravities and being stratifiable in a centrifugal field produced a centrifuge , said method comprising:a) providing a centrifuge having a chamber, an inlet, a first port and a second port, said chamber having a central longitudinal axis and comprising an assembly of a tubular barrel and an end wall arranged to contain a liquid mixture, said first port being located a first radial distance from said central longitudinal axis, said second port being located a second radial distance from said central longitudinal axis, said second radial distance being smaller than said first radial distance;b) introducing said biologic liquid mixture into said chamber;c) rotating said chamber about said central longitudinal axis to produce said centrifugal field, whereupon said constituents of said liquid mixture in said chamber stratify into at least two concentric stratified constituent layers as a function of the differing specific gravities of said constituents and wherein a first one of said at least two concentric stratified constituent layers is present ...

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13-02-2014 дата публикации

CENTRIFUGATION SYSTEM WITH RED BLOOD CELL BARRIER

Номер: US20140045671A1
Принадлежит: Fenwal, Inc.

Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port. 1. A centrifugation system comprising , in combination: a generally annular low-G wall, and', 'a generally annular high-G wall located farther from the rotational axis than the low-G wall, wherein the high-G wall includes a first projection extending toward the low-G wall and the low-G wall includes a second projection extending toward the high-G wall; and, 'a centrifuge configured to separate blood components from blood by rotation about a rotational axis and comprising'} an inlet port configured for flowing blood into the separation chamber,', 'a plasma outlet port for flowing a separated blood component substantially comprising plasma out of the separation chamber, and', 'a red cell outlet port for flowing a separated blood component substantially comprising red blood cells out of the separation chamber wherein, when the separation chamber is received in the centrifuge between the low-G and high-G walls, the first projection is oriented so as to extend into the path of separated blood components flowing toward the plasma outlet port and prevent the separated blood ...

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13-02-2014 дата публикации

DISPOSABLE DEVICE FOR CENTRIFUGAL BLOOD SEPARATION

Номер: US20140045672A1
Принадлежит: Sorin Group Italia S.r.l.

A continuous centrifugal blood separation device has a simple and reliable structure. The continuous blood centrifugal device includes an RBC (red blood cell) collector that is coaxial with a supernatant collector. The continuous blood centrifugal device includes an axial symmetric barrier disposed between the RBC collector and the supernatant collector in order to avoid turbulence that can otherwise be caused by the supernatant collector. 1. A disposable continuous blood centrifugal device comprising:a rotatable housing;a rotatable inner bowl disposed within the rotatable housing and defining a space between the rotatable inner bowl and the rotatable housing, the space sized to permit blood to separate into layers, with a more dense layer closest to the rotatable housing and a less dense layer closest to the rotatable inner bowl;a first collector configured to collect blood components from within the more dense layer;a second collector configured to collect blood components from within the less dense layer;a rotatable barrier disposed within the rotatable housing above the rotatable inner bowl, the rotatable barrier configured to direct blood components within the more dense layer towards the first collector and to direct blood components within the less dense layer towards the second collector; anda stationary structure extending downwardly through the rotatable housing and the rotatable inner bowl, the stationary structure including a blood inlet, a first outlet in fluid communication with the first collector and a second outlet in fluid communication with the second outlet.2. The continuous blood centrifugal device of claim 1 , wherein a first collection chamber in which the first collector is disposed is formed between the rotatable barrier and a top of the rotatable housing.3. The continuous blood centrifugal device of claim 1 , wherein a second collection chamber in which the second collector is disposed is formed within the rotatable barrier or between the ...

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27-02-2014 дата публикации

OPTICAL MONITORING SYSTEM FOR BLOOD PROCESSING SYSTEM

Номер: US20140057771A1
Принадлежит: Fenwal, Inc.

An optical monitoring system is provided for use with a blood processing system. The system includes a light source configured to illuminate a disposable flow circuit received in a centrifuge and a light detector configured to receive an image of the disposable flow circuit. A controller combines two or more of the images received by the light detector to generate a two-dimensional output. The output is used to control the separation of blood within the disposable flow circuit. The monitoring system may also be used to verify that the disposable flow circuit is suitable for use with the centrifuge or that the disposable flow circuit is properly aligned within the centrifuge. The monitoring system may be positioned outside of the centrifuge bucket which receives the centrifuge. 1. A disposable flow circuit for use in a blood processing system of the type including a centrifuge and an optical monitoring system , comprisinga blood separation chamber configured to be at least partially received inside the centrifuge for the flow of whole blood and/or a separated blood component therethrough;an inlet tube for the flow of whole blood into the blood separation chamber; andan outlet tube for the flow of a separated blood component out of the blood separation chamber, wherein the blood separation chamber includes at least one identification feature configured to be detected by the monitoring system when the blood separation chamber is received inside the centrifuge to verify that the blood separation chamber is suitable for use with the centrifuge.2. The disposable flow circuit of claim 1 , wherein said at least one identification feature comprises a barcode.3. The disposable flow circuit of claim 1 , wherein said at least one identification feature comprises a printed image.4. The disposable flow circuit of claim 1 , wherein said at least one identification feature comprises a material thickness different from the material thickness of the blood separation chamber adjacent ...

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06-03-2014 дата публикации

BLOOD BAG SYSTEMS FOR SEPARATION OF WHOLE BLOOD AND METHODS OF USE THEREOF

Номер: US20140066281A1
Принадлежит:

The present disclosure relates generally to systems for processing a unit of whole blood into its components while the unit is still in the centrifuge. The system comprises a container holding whole blood and one or more satellite bags or containers that are installed into a holder, which is then inserted into a bucket of the centrifuge. Tubes interconnect the containers, one or more of which are preferably installed into clamping mechanisms resident in the holder. The holder further preferably includes sensing means, such as optical sensors, to sense the location of the interfaces between the separated layers of the whole blood that result from rotation of the centrifuge. 120-. (canceled)21. A blood bag system for separation of whole blood into at least two separate blood components with a centrifuge system comprising a rotor rotatable about an axis of rotation , the blood bag system comprising:a first deformable container of whole blood, the first container having a volume greater than the volume of whole blood therein;a second deformable container of whole blood, the second container having a volume greater than the volume of whole blood therein;the first and second containers and the volume of blood contained therein being substantially identical;a holder being configured for mounting to the rotor of the centrifuge for rotation therewith, the holder having a receptacle comprising first, second and third compartments positioned sequentially and symmetrically about a radius of the rotor with a relatively narrow channel separating each of the first compartment from the second compartment and the second compartment from the third compartment, the first, second and third compartments receiving the first and second containers therein with the first deformable container of whole blood being received in the receptacles such that substantially all of the whole blood is contained in the first compartment and the second deformable container of whole blood being received in ...

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06-03-2014 дата публикации

Drive system for centrifuge

Номер: US20140066282A1
Принадлежит: Fenwal Inc

A drive assembly for a centrifugal processing system is provided for rotating the yoke assembly ( 36 ) about a first axis at a first angular velocity and rotating the chamber assembly ( 30 coaxially with the yoke assembly at a second angular velocity A drive motor ( 54 ) is provided for rotating the yoke assembly at the first angular velocity and simultaneously rotating the chamber assembly at the second angular velocity by means of a stationary first gear ( 64 ), a second gear ( 68 ) mounted to the yoke assembly that operatively engages the first gear, a third gear ( 74 ) rotatably mounted to the yoke assembly so as to synchronously rotate with the second gear, and a fourth gear ( 76 ) fixed to the chamber assembly that operatively engages the third gear so as to rotate the chamber assembly ( 30 ) relative to the yoke assembly ( 36 ) upon rotation of the yoke assembly about the first gear.

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27-03-2014 дата публикации

LIQUID SWITCHING, DOSING AND PUMPING

Номер: US20140087934A1
Принадлежит: BIOSURFIT, S.A.

A liquid handling device having an upstream liquid handling structure connected to a downstream liquid handling structure by a conduit. The upstream and downstream liquid handling structures are sealed or sealable such that the conduit provides the only fluidic communication paths between the upstream and downstream liquid handling structure. The device is arranged such that a driving force causes liquid in the upstream liquid handling structure to at least partially fill the conduit to separate gas in the upstream liquid handling structure from gas in the downstream liquid handling structure. With the device set up such that the two gas volumes are separated by a liquid volume, gas pressures and liquid flow in the device can be controlled by control of the driving force. The device may be arranged for rotation about an axis of rotation to provide the driving force. 1. A device for handling liquid comprising:an upstream liquid handling structure;a downstream liquid handling structure; anda conduit connecting the upstream liquid handling structure to the downstream liquid handling structure to enable liquid to flow from the upstream liquid handling structure to the downstream liquid handling structure in response to a driving force, wherein the upstream and downstream liquid handling structures are sealed or sealable such that the conduit provides the only fluidic communication path between the upstream liquid handling structure and the downstream liquid handling structure, the device being arranged such that the driving force causes liquid in the upstream liquid handling structure to at least partially fill the conduit to separate gas in the upstream liquid handling structure from gas in the downstream liquid handling structure.2. A device as claimed in claim 1 , the device being arranged for rotation about an axis of rotation to provide the driving force and the upstream liquid handling structure comprising a liquid holding chamber.3. A device as claimed in claim 2 ...

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27-03-2014 дата публикации

Method And Apparatus For Separating A Material

Номер: US20140088492A1
Принадлежит: Biomet Biologics, LLC

A separation system for separating a multiple component material into at least two fractions. The separation system includes a separation device having a first end, a second end opposite to the first end, and a sidewall that extends between the first end and the second end to define a separation chamber having an interior volume. The system also includes a valve moveable between an open position and a closed position, the valve is mounted at a fixed location within the separation chamber at a position that is closer to the second end than to the first end and is spaced apart from the second end, the valve is operable to isolate a first fraction of the multiple component material having a first density on a first side of the valve from a second fraction having a second density on a second side of the valve that is opposite to the first side. 1. A method for isolating at least two fractions of a multiple component material comprising:loading the multiple component material into a separation chamber of a separation device between a valve mounted at a fixed position in the separation chamber and a first end of the device, the first end is opposite to a second end and a sidewall extends between the first end and the second end to define the separation chamber having an interior volume;centrifuging the separation device such that the valve moves to an open position in response to gravitational forces exerted on the device to permit a first fraction of the multiple component material of a first density to pass through the valve toward the second end;ceasing centrifugation of the separation device to permit the valve to move to a closed position, thus isolating the first fraction of the first density between the valve and the second end and isolating a second fraction of a second density that is less dense than the first density between the valve and the first end; andwithdrawing at least one of the first fraction and the second fraction from the separation chamber for use ...

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03-04-2014 дата публикации

CENTRIFUGE

Номер: US20140094930A1
Принадлежит:

Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants. 121.-. (canceled)22. A method of selectively concentrating and collecting constituents of a biologic liquid mixture and applying a portion of said constituents to a scaffold material , said constituents having differing specific gravities and being stratifiable in a centrifugal field produced a centrifuge , said method comprising:a) providing a centrifuge having a chamber, an inlet and a first port, said chamber having a central longitudinal axis and being arranged to contain a liquid mixture;b) introducing said biologic liquid mixture into said chamber;c) rotating said chamber about said central longitudinal axis to produce said centrifugal field, whereupon said constituents of said liquid mixture in said chamber stratify into at least two concentric stratified constituent layers as a function of the differing specific gravities of said constituent;d) selectively opening said first port to enable at least a portion of at least one of said at least two concentric stratified constituent layers to be discharged from said chamber through said first port thereby leaving a residual of said biologic liquid mixture in said chamber; ande) discharging at least a portion of said ...

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10-04-2014 дата публикации

Three-Line Apheresis System and Method

Номер: US20140100506A1
Принадлежит: Haemonetics Corporation

A blood processing system for collecting and exchanging blood components includes a venous-access device for drawing whole blood from a subject and returning blood components to the subject. The system may include three lines connecting the venous access device to a blood component separation device and an anticoagulant source. A blood draw line fluidly connects to the venous-access device to the blood component separation device. An anticoagulant line introduces anticoagulant into the drawn whole blood. A return line, fluidly connected to the venous-access device and the blood component separation device, returns uncollected blood component to the subject. Each line may have a pump that controls flow through the line. The blood component separation device separates the drawn blood into a first blood component and a second blood component, and may be configured to send the first blood component to a first blood component bag. 1. A method of collecting and exchanging blood components comprising:(a) inserting a venous-access device into a subject, the venous-access device connected to a draw line, an anticoagulation line, and a return line;(b) withdrawing blood from the subject through the draw line, the draw line connected to a blood component separation device, the flow through the draw line being controlled by a draw line pump;(c) introducing anticoagulant into the withdrawn blood through the anticoagulant line, the flow through the anticoagulant line being controlled by an anticoagulant line pump;(d) separating the withdrawn blood into a first blood component and a second blood component using the blood component separation device;(e) extracting the first blood component from the blood component separation device;(f) returning the second blood component to the patient through the return line, the flow through the return line being controlled by a return line pump, wherein the return line fluidly connects to the venous-access device at a point between the draw line ...

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07-01-2021 дата публикации

CONTINUOUS FLOW SEPARATION CHAMBER

Номер: US20210001035A1
Принадлежит:

A continuous flow centrifuge bowl includes a rotatable outer body, and a top and bottom core that are rotatable with the outer body. The bottom core has a wall extending proximally from a bottom wall. The proximally extending wall is radially outward from at least a portion of the top core and, together with the top core, defines a primary separation region in which initial separation of the whole blood occurs. The bowl may also have a secondary separation region located between the top core and the outer body, and a rotary seal that couples an inlet port and two outlet ports to the outer body. The inlet port may be connected to an inlet tube that extends distally into a whole blood introduction region. Additionally, one of the outlet ports may be connected to an extraction tube that extends into a region below the bottom core. 1. A centrifuge bowl for continuous separation of whole blood comprising:an outer body rotatable about a longitudinal axis of the centrifuge bowl;a top core located within and rotatable with the outer body, the top core being coaxial with the outer body and having a chimney extending through the top core along the longitudinal axis of the centrifuge bowl;a separation region located between the top core and the outer body, rotation of the centrifuge bowl separating the whole blood within the separation region into a first blood component and a second blood component;an inlet port for introducing whole blood into the centrifuge bowl;an inlet tube fluidly connected to and extending distally from the inlet port and through the chimney, the inlet tube configured to introduce the whole blood into an introduction region;a bypass seal between an outer diameter of the inlet tube and an inner diameter of the chimney, the bypass seal isolating the introduction region from the chimney;a first blood component outlet port for drawing a first blood component out of the centrifuge bowl;a first blood component extraction tube extending from the first blood ...

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02-01-2020 дата публикации

Loading of Disposable

Номер: US20200005479A1
Принадлежит:

Described are embodiments that include methods and devices for detecting disposables that may be used in medical devices. Embodiments involve the detection of disposables used in apheresis machines. The disposable are configured to fit into portions, or features, of the apheresis machines in predetermined ways and embodiments provide for detecting whether the disposable have been loaded correctly. 1. A system for identifying incorrect loading of a disposable in a fluid separation system , the system comprising:a light source that directs light at an edge of a centrifuge used to separate fluid into components, the edge being adjacent a channel configured to hold a separation vessel in which the fluid is separated into the components;a detector for detecting light from the light source, wherein the detector detects light scattered by a separation vessel incorrectly loaded into the channel; anda processor connected to the detector, wherein when the detector detects the light scattered by the incorrectly loaded separation vessel, the processor sends a signal to perform an action.2. The system of claim 1 , wherein the detector comprises a first camera.3. The system of claim 2 , wherein the action comprises an alarm.4. The system of claim 3 , wherein the action comprises an audio alarm.511-. (canceled)12. A system for identifying incorrect loading of a disposable in a fluid separation system claim 3 , the system comprising:a first camera for capturing first image data of a first position where a disposable is engageable with a portion of a centrifuge assembly; andat least one processor for comparing the first image data to first reference image data, wherein when the first image data differs from the first reference image data, the at least one processor sending a signal to perform an action.13. The system of claim 12 , wherein the action comprises an alarm.14. The system of claim 13 , wherein the action comprises an audio alarm.1520-. (canceled)21. A method of ...

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14-01-2016 дата публикации

SYSTEM AND METHOD FOR BLOOD SEPARATION BY MICROFLUIDIC ACOUSTIC FOCUSING

Номер: US20160008532A1
Принадлежит:

Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study. 1. A blood cleansing device comprising:a thermoplastic microfluidic separation channel having an upstream portion and downstream portion, the separation channel comprising:a first inlet configured to introduce flowing whole blood into a proximal portion of the separation channel, the whole blood including plasma, a plurality of formed elements and a plurality of undesirable particles;a first outlet at the downstream portion of the separation channel positioned substantially along the longitudinal axis of the separation channel;a second outlet at the downstream portion positioned adjacent a first wall of the separation channel; andan acoustic transducer positioned adjacent to the separation channel for imposing a standing acoustic wave transverse to the flow of blood through a particle migration region of the separation channel, wherein a width of the separation channel is between about 30% and 45% of a wavelength of the standing acoustic wave.2. The blood cleansing device of claim 1 , wherein the width of the separation channel is between ...

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09-01-2020 дата публикации

APPARATUS AND METHODS FOR PROCESSING BLOOD

Номер: US20200009304A1
Принадлежит: Hanuman Pelican, Inc.

Apparatus and methods for processing blood are disclosed in which one variation generally comprises a tube defining a channel and an access tube extending into the channel. An open cell matrix configured to entrap red blood cells may be positioned within at least a portion of the channel. Another variation generally comprises a cylindrical tube and a plunger slidably positioned within the channel. The plunger also has a funnel positioned upon the plunger and is movable therewith. Both the plunger and funnel define a fluid channel through and in communication with the cylindrical tube. 1. A separation apparatus , comprising:a cylindrical tube defining an opening and a channel extending therethrough;a plunger defining a plunger fluid opening and slidably positioned within the channel; anda funnel positioned upon the plunger and movable therewith, wherein the funnel defines a funnel fluid opening in fluid communication with the plunger fluid opening.2. The apparatus of further comprising a tubing removably coupled to the second fluid opening of the funnel and extending through the opening of the cylindrical tube.3. The apparatus of wherein the cylindrical tube defines a closed floor opposite of the opening of the cylindrical tube.4. The apparatus of wherein the funnel is positioned upon a first side of the plunger in proximity to the opening of the cylindrical tube.5. A method of separating components from blood claim 1 , comprising:introducing a volume of blood through a funnel and a plunger and into a channel defined by a cylindrical tube such that the funnel and plunger are moved from a first position within the tube to a second position in proximity to an opening defined by the tube;applying a centrifugal force to the volume of blood contained within the tube such that the blood forms at least a first fractional layer and a second fractional layer; andwithdrawing at least the first fractional layer from the tube via the funnel and the plunger such that the funnel ...

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09-01-2020 дата публикации

SYSTEMS AND METHODS FOR CONCENTRATING CELLS WITH A SYRINGE AND A CENTRIFUGE

Номер: US20200009312A1
Принадлежит:

A system for concentrating cells, wherein a syringe comprises a lumen and an axial end comprising a port and a radial end closed to liquid flow. A plunger divides the axial and radial ends, and the syringe is configured to hold a cellular suspension. A filter disposed at the radial end is configured to maintain sterility of the syringe. A cap comprises a vent disposed at the radial end. The plunger is configured to be actuated towards the axial end by air pressure being applied into the radial end and the plunger is configured to be actuated towards the radial end by a vacuum being applied into the radial end. 1. A system for concentrating cells , comprising:a syringe comprising a lumen and an axial end comprising a port and a radial end closed to liquid flow, wherein a plunger divides the axial and radial ends, and wherein the syringe is configured to hold a cellular suspension;a filter disposed at the radial end configured to maintain sterility of the syringe;a cap comprising a vent disposed at the radial end;wherein the plunger is configured to be actuated towards the axial end by air pressure being applied into the radial end and the plunger is configured to be actuated towards the radial end by a vacuum being applied into the radial end.2. The system of claim 1 , further comprising an actuator handle configured for attachment with a radial side of the plunger for actuation using a solid contact force claim 1 , and wherein the filter and the cap are removable from the radial end of the syringe.3. The system of claim 1 , wherein the plunger comprises a visible indicator indicative of a relative position of the plunger between the axial and radial ends.4. The system of claim 1 , wherein the lumen of the syringe comprises a capacity of 50-60 mL.5. The system of claim 1 , further comprising a syringe holder configured to fit in a cavity of a centrifuge rotor having an axis of rotation claim 1 , wherein the syringe holder is configured to receive the syringe ...

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08-01-2015 дата публикации

Blood Component Separation Device

Номер: US20150011371A1
Принадлежит:

Provided is a blood component separation device that can shorten the overall time to collect high-concentration platelet liquid for blood component donation, thereby reducing time to keep a donor for blood drawing. The blood component separation device includes a temporary storage bag (also used as a buffy coat bag) which is also used as a whole blood bag for storing whole blood drawn from the donor. A control means performs whole blood drawing from the donor in parallel with performing at least either of a circulation flow step and an acceleration step, thereby storing the collected whole blood in the temporary storage bag. 1. A blood component separation device comprising:a centrifugal separator configured to separate a predetermined blood component from blood; anda container for containing the predetermined blood component centrifugally separated, wherein (a) centrifugal separation step for introducing whole blood drawn from a donor into the centrifugal separator to separate the whole blood into a plurality of blood components,', '(b) circulation flow step for introducing a predetermined first blood component, among centrifugally separated blood components, into the centrifugal separator together with whole blood, and', '(c) circulation/acceleration step, performed after a predetermined amount of the first blood component is separated in the circulation flow step, in which supply of whole blood to the centrifugal separator is stopped to introduce only the first blood component into the centrifugal separator to further circulate the first blood component for a predetermined period of time, and a circulation speed is then increased so that a second blood component is separated by the centrifugal separator to be collected, and, 'the blood component separation device is configured to perform'}whole blood collected from the donor is temporarily stored in a temporary storage container during at least a time period in the circulation/acceleration step.2. The blood ...

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11-01-2018 дата публикации

PREPARING ANTIGEN-SPECIFIC T CELLS USING A SELF-ENCLOSED PROCESSING SYSTEM THAT CONTAINS BOTH A CENTRIFUGE AND A MAGNETIC SEPARATION COLUMN

Номер: US20180010087A1
Принадлежит: Miltenyi Biotec GmbH

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (), a pump () and a plurality of valves (-) configured to at least partially control fluid flow through a fluid circuitry and a separation column () positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column. 1. A method of enriching a defined population of target cells from a mixed population of blood cells using an apparatus that is configured for processing such cells using a sterile tubing set;wherein the tubing set comprises:(a) a first connecting member configured to receive and deliver the sample to a rotatable container,(b) said rotatable container, which is configured to rotate about an axis and thereby to apply centrifugal force to a sample contained in a processing chamber in the container so as to separate cells from the sample from other components of the sample;(c) a second connecting member configured to transfer cells processed by the rotatable container to a cell separation column;(d) said separation column, which is configured to separate labeled cells from unlabeled cells; and(e) a third connecting member configured to transfer cells separated by the cell separation column to a product collection container;wherein the method comprises:(1) delivering the sample through the first connecting member into the tubing set; and(2) operating the apparatus such that the sample is ...

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09-01-2020 дата публикации

CENTRIFUGAL DEAERATOR FOR A TURBOMACHINE

Номер: US20200011246A1
Принадлежит:

The invention relates to a centrifugal deaerator for an air/oil mixture of a turbomachine, comprising: an annular housing () for the centrifugal separation of said mixture, arranged around a hollow shaft (); axial inlets () for the flow of said air/oil mixture into said housing (); a pinion () for rotating said housing (); and radial oil outlets () and oil-free air outlets (), characterised in that it comprises a metal foam () housed in said housing () by partially extending along the axial direction (XX′) so as to define two successive spaces, a foam-free space () and a foam-lined space (), said foam-free space opening up towards said axial inlets. A device can be advantageously added to the hollow shaft in order to reduce the free-vortex phenomenon and to thereby significantly reduce the load losses of the deaerator. 1. Centrifugal deaerator for an air/oil mixture of a turbomachine comprising:an annular housing for the centrifugal separation of said mixture arranged around a hollow shaft extending along a direction, so-called axial direction, and delimited by an outer annular wall and an inner annular wall,at least one axial inlet of said air/oil mixture in said housing,a pinion for rotating said housing comprising a web securely connected to said inner and outer annular walls such that a rotation of said pinion drives said housing in rotation,at least one radial oil outlet arranged in said outer wall and configured to be able to evacuate the oil separated from said mixture towards the outside of the deaerator,at least one de-oiled air outlet arranged in said inner wall and configured to be able to evacuate the de-oiled air towards said hollow shaft,characterised in that it comprises a metal foam housed in said housing by extending partially along said axial direction so as to delimit two successive spaces along the axial direction (X′X), a foam-free space and a foam-lined space, said foam-free space opening onto said axial inlet(s).2. Deaerator according to claim ...

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03-02-2022 дата публикации

CENTRIFUGE

Номер: US20220031925A1
Принадлежит:

Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants. 127-. (canceled)30. A centrifuge for isolating and concentrating a fraction of a biologic liquid mixture comprising:a. a chamber having a longitudinal axis, a first end, a second end, and a sidewall extending between said first end and said second end, wherein at least a portion of said sidewall is transparent;b. a first port provided in said chamber at a first radial distance from said longitudinal axis, and in fluid communication with a first valve;c. a second port provided in said chamber at a second radial distance from said longitudinal axis, and in fluid communication with a second valve, said second radial distance being less than said first radial distance;d. a motor configured to rotate said chamber about said longitudinal axis and thereby produce a centrifugal field;wherein the sidewall is configured to direct toward the first port a biologic liquid mixture that is present in the chamber and experiencing a centrifugal field.31. The centrifuge of claim 30 , wherein the sidewall extends from the first end to the second end in a first direction that is away from the longitudinal axis.32. The centrifuge of claim 30 , wherein the sidewall extends from the first end to ...

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03-02-2022 дата публикации

Improvements to Centrifuge Apparatus

Номер: US20220032324A1
Автор: Bright Colin, Rooke David
Принадлежит:

Apparatus used to allow separation of one or more components from a liquid supplied to the apparatus and then, following use of the apparatus, the one or more separated components can be used for further purposes. The apparatus includes a rotatable shaft to which is mounted one or more columns which rotate with the shaft and which also rotate about their own axes and through which the liquid passes. The columns are provided with liquid from flying lead assemblies and the invention provides improved connecting means between the columns and flying lead assemblies to allow the same to be modular. An improved cooling system is also disclosed. 1. Centrifuge apparatus including a drive shaft and at least one column provided to be rotated by the shaft around the same , said apparatus further comprising: a flying lead assembly to allow passage of a liquid introduced into the apparatus and allow separation of one or more components from the liquid , wherein connection means are provided for attaching the flying lead assembly to the at least one column to allow the flying lead assembly and/or column to be modular.2. The apparatus according to claim 1 , wherein the flying lead assembly and column modules are interchangeable with a remainder of the apparatus.3. The apparatus according to claim 1 , wherein the connection means form and maintain a pathway for the liquid and the liquid dynamics between the flying lead assembly and the column.4. The apparatus according to claim 1 , wherein the connection means are provided so as to achieve connection with a range of columns of different shapes.5. The apparatus according to claim 1 , wherein the connection means are reusable.6. The apparatus according to claim 3 , wherein the connection means include an insert part which is located in the liquid pathway.7. The apparatus according to claim 6 , wherein the insert part regulates the liquid pressure as it passes through the connection means.8. The apparatus according to claim 7 , ...

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17-01-2019 дата публикации

Apparatus, Systems And Methods For Preparing And Shipping Samples

Номер: US20190015827A1
Принадлежит:

The disclosed apparatus, systems and methods relate to sample preparation and shipping technologies in a single shippable container. The shipping container contains a single use centrifuge. The centrifuge can be temperature controlled and meets all standards and regulations for the shipping and transport of biological specimens. 1. A system for sample preparation and transportation comprising:a. an openable shippable container; andb. a centrifuge frame comprising a rotor, the centrifuge frame being disposed within the shipping container,wherein the centrifuge frame is constructed and arranged to centrifuge and ship a biological sample.2. The system of claim 1 , wherein the centrifuge frame is constructed and arranged so that the rotor is actuated by closing the openable shipping container.3. The system of claim 1 , wherein the rotor contains an opening for a biological sample and an integrated counter-balancing weight.4. The system of claim 1 , comprising electronics claim 1 , and wherein the rotor is constructed and arranged so as to be a single-use rotor.5. The system of claim 1 , wherein the centrifuge frame comprises at least one switch constructed and arranged to control the operation of the rotor.6. The system of claim 5 , further comprising a battery in operational communication with the at least one switch.7. The system of claim 6 , wherein the shipping container comprises a lid claim 6 , the lid being in operational communication with the at least one switch.8. The system of claim 1 , wherein the centrifugation frame comprises at least one battery and a PCB that is operationally coupled to the rotor claim 1 , wherein the PCB is constructed and arranged to be pre-programmed for a variety of sample types.9. The system of claim 8 , wherein the PCB is operationally integrated with communications components that are constructed and arranged to wirelessly communicate with a receiver.10. The system of claim 9 , wherein the receiver is constructed and arranged to ...

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21-01-2021 дата публикации

METHOD OF EXTRACTING ONE OR MORE CHEMICAL EXTRACTS FROM A PLANT PRODUCT

Номер: US20210016202A1
Автор: Gildrien Jeremy
Принадлежит:

A method of extracting one or more chemical extracts from a plant product includes mixing at least a first phytochemical-bearing part of a phytochemical plant product with an oil-bearing plant product, producing an oil mixture from the first phytochemical-bearing part and the oil-bearing plant product using a press device, and extracting at least a chemical extract from the oil mixture. 1. A method of extracting one or more chemical extracts from a plant product , the method comprising:mixing at least a first phytochemical-bearing part of a phytochemical plant product with an oil-bearing plant product;producing an oil mixture from the first phytochemical-bearing part and the oil-bearing plant product using a press device; andextracting at least a chemical extract from the oil mixture.2. The method of claim 1 , wherein the oil-bearing plant product comprises at least an oil-bearing seed.3. The method of claim 1 , wherein the oil-bearing plant product further comprises at least an oil-bearing meal.4. The method of claim 1 , wherein the press device further comprises an oil press device.5. The method of claim 1 , wherein the press device further comprises a rosin press device.6. The method of claim 1 , wherein producing the oil mixture further comprises applying pressure to the at least a phytochemical-bearing part and the oil-bearing plant product.7. The method of claim 1 , wherein producing the oil mixture further comprises heating the at least a phytochemical-bearing part and the oil-bearing plant product.8. The method of claim 7 , wherein heating the at least a phytochemical-bearing part and the oil-bearing plant product further comprises heating the at least a phytochemical-bearing part and the oil-bearing plant product prior to insertion in the press device.9. The method of claim 7 , wherein heating the at least a phytochemical-bearing part and the oil-bearing plant product further comprises heating the at least a phytochemical-bearing part and the oil-bearing ...

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17-01-2019 дата публикации

Methods for Inducing the Differentiation of Blood Monocytes into Functional Dendritic Cells

Номер: US20190017025A1
Принадлежит: YALE UNIVERSITY

Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood and produce a leukocyte concentrate comprising monocytes and plasma containing proteins. The leukocyte concentrate comprising monocytes and plasma containing proteins is pumped through a plastic treatment device, such as a photopheresis device. The resulting treated cells may be incubated for a sufficient period of time to allow the monocytes to form dendritic cells, or the treated cells may be reinfused directly to the subject.

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10-02-2022 дата публикации

Centrifugal Contactor Including Central Dynamic Examination Device

Номер: US20220040596A1
Принадлежит:

Centrifugal contactors that can be used for mixing or separating materials are described. The contactors include a sensing system including a communications fiber within the shaft of the contactors and access ports providing access from the communications fiber to the mixing/separating zone of the contactor. The sensing system can be utilized during operation of the contactor and can provide for detailed and accurate on-line characterization of a protocol, as well as process control and system modification as necessary during operation. 1. A centrifugal contactor comprising:a housing;a shaft within the housing, the shaft comprising a cylindrical wall surrounding a hollow core with a longitudinal central axis and an access port within the cylindrical wall;a plurality of rotor blades configured to revolve about the longitudinal central axis, the plurality of rotor blades defining a zone within the housing;a communications fiber comprising a first end and a second end, the first end being locatable within the hollow core in communications with the access port; anda signal generator or signal receiver in communication with the second end of the communications fiber.2. The centrifugal contactor of claim 1 , wherein the centrifugal contactor is a centrifugal separator.3. The centrifugal contactor of claim 1 , wherein the centrifugal contactor is an impeller mixed tank.4. The centrifugal contactor of claim 1 , wherein the communications fiber comprises an optical fiber.5. The centrifugal contactor of claim 1 , wherein the communications fiber comprises a plurality of optical fibers.6. The centrifugal contactor of claim 1 , wherein the access port is optically transmissive.7. The centrifugal contactor of claim 6 , wherein the access port is optically transmissive to one or more wavelengths in the infrared spectrum.8. The centrifugal contactor of claim 1 , wherein the access port comprises an acoustically responsive diaphragm.9. The centrifugal contactor of claim 1 , the ...

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22-01-2015 дата публикации

Multi-Unit Blood Processor With Temperature Sensing

Номер: US20150024920A1
Автор: DOLECEK Victor D.
Принадлежит:

Method and apparatus for centrifugal blood component separation including temperature sensing in each of a plurality of separation cells. The temperature of unit of bloods over time is recorded. If the temperature of any of the units exceeds a pre-determined maximum, portions of the blood separation device may be cooled. A controller may determine which of the units to process first, generally proceeding from the warmest unit to the coolest. The order of unit processing may be changed during processing. The detected temperature may be used to calibrate a pressure sensor used to predict the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags. 14-. (canceled)5. An apparatus for separating blood comprisinga rotor having a plurality of separation cavities and a plurality of collection cavities for centrifugally separating a plurality of distinct units of blood into first separated components and at least second separated components;a plurality of separation bags, each containing a unit of blood and adapted to be disposed in a separation cavity;at least one collection bag in each collection cavity;tubing connecting the separation bag to at least one collection bag;a temperature sensor for detecting a temperature of the composite fluid in the separation bag in the separation cavity;a controller comprisingmeans for establishing an order for processing each of the units of blood in response to the sensed temperatures of the units of blood.6. The apparatus of wherein the controller further comprises means for recording temperatures of the units of blood throughout processing of all units andmeans for changing the order for processing each of the units of blood in response to sensed changes in the temperatures of un-processed units of blood.720-. (canceled) This application claims the ...

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24-01-2019 дата публикации

Paperfuge: An integrated paper-based centrifugation and microfluidics platform for low-cost diagnostics

Номер: US20190022642A1
Принадлежит:

A microfluidic centrifuge is provided that includes a microfluidic disc having a pair of through holes that include a first through hole and a second through hole, where the pair of through holes are disposed symmetric and proximal to a central axis of the microfluidics disc, where the microfluidics disc includes a sealable input port and a sealable output port, where the sealable input port and the sealable output port are connected by a microfluidics channel, and a pair of tethers disposed through the pair of through holes that are disposed to twist about each other for unwinding where the tether unwinding is disposed to interact with the through holes, where the microfluidics disc rotates about the central axis. 1) A microfluidic centrifuge , comprising a microfluidic disc having a pair of through holes comprising a first through hole and a second through hole , wherein said pair of through holes are disposed symmetric and proximal to a central axis of said microfluidics disc , wherein said microfluidics disc comprises a sealable input port and a sealable output port , wherein said sealable input port and said sealable output port are connected by a microfluidics channel.2) The microfluidics centrifuge of claim 1 , wherein said microfluidics disc comprises a housing material selected from the group consisting of paper claim 1 , polymethyl methacrylate claim 1 , polydimethylsiloxane claim 1 , and plastic.3) The microfluidics centrifuge of further comprises a first tether and a second tether forming a pair of tethers claim 1 , wherein said pair of tethers are disposed through said pair of through holes claim 1 , wherein said pair of tethers are disposed to twist about each said tether for unwinding claim 1 , wherein said tether unwinding is disposed to interact with said through holes claim 1 , wherein said microfluidics disc rotates about said central axis.4) The microfluidics centrifuge of claim 1 , wherein said sealable input port is disposed proximal to said ...

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10-02-2022 дата публикации

INCREASING RESPONSES TO CHECKPOINT INHIBITORS BY EXTRACORPOREAL APHERESIS

Номер: US20220041729A1
Принадлежит: IMMUNICOM, INC.

The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway. 118-. (canceled)19. A method of enhancing an efficacy of an antibody administered to a patient , comprising the steps of:(a) administering an antibody capable of suppressing activity of a PD-L2 molecule; and(b) extracorporeally removing an immunological blocking factor that inhibits the effectiveness of the antibody from blood or a blood component of the patient.20. The method of claim 19 , wherein the antibody is selected from the group consisting of AMP-224 and rHIgM12B7.21. The method of claim 19 , wherein the immunological blocking factor is a soluble tumor necrosis factor (TNF)-alpha receptor.22. The method of claim 21 , wherein step (b) is performed using an affinity capture substrate that comprises an immobilized TNF-alpha molecule comprising one or more of a native TNF-alpha molecule and a mutated TNF-alpha molecule.23. The method of claim 22 , wherein the immobilized TNF-alpha molecule is a trimer.24. The method of claim 19 , further comprising after step (b) administering an antibody capable of suppressing activity of a PD-L2 molecule one or more additional times to the patient.25. The method of claim 19 , further comprising after step (b) extracorporeally removing one or more additional times an immunological blocking factor that inhibits the effectiveness of the antibody from blood or a blood component of the patient.26. The ...

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10-02-2022 дата публикации

INCREASING RESPONSES TO CHECKPOINT INHIBITORS BY EXTRACORPOREAL APHERESIS

Номер: US20220041730A1
Принадлежит: IMMUNICOM, INC.

The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment. removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway. 118-. (canceled)19. A method of enhancing an efficacy of an antibody administered to a patient , comprising the steps of:(a) administering an antibody capable of suppressing activity of a checkpoint protein selected from the group consisting of B7-H3 and B7-H4; and(b) extracorporeally removing an immunological blocking factor that inhibits the effectiveness of the antibody from blood or a blood component of the patient.20. The method of claim 19 , wherein the antibody is MGA271.21. The method of claim 19 , wherein the immunological blocking factor is a soluble tumor necrosis factor (TNF)-alpha receptor.22. The method of claim 21 , wherein the step of extracorporeally removing the soluble TNF-alpha receptor alpha receptor is performed using an affinity capture substrate that comprises an immobilized TNF-alpha molecule comprising one or more of a native TNF-alpha molecule and a mutated TNF-alpha molecule.23. The method of claim 22 , wherein the immobilized TNF-alpha molecule is a trimer.24. The method of claim 19 , further comprising after step (b) administering an antibody capable of suppressing activity of a checkpoint protein selected from the group consisting of B7-H3 and B7-H4 one or more additional times to the patient.25. The method of claim 19 , further comprising after step (b) extracorporeally removing one or more additional times ...

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10-02-2022 дата публикации

INCREASING RESPONSES TO CHECKPOINT INHIBITORS BY EXTRACORPOREAL APHERESIS

Номер: US20220041731A1
Принадлежит: IMMUNICOM, INC.

The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway. 118-. (canceled)19. A method of enhancing an efficacy of an antibody administered to a patient , comprising the steps of:(a) administering an antibody capable of suppressing activity of a checkpoint protein selected from a group consisting of a LAG3, a Tim3, a 2B4, a A2aR, a ID02, a BTLA, a DR3, a GAL9, a HVEM, a ID01, a KIR, a LAIR, a LIGHT, a MARCO, a PS, a SLAM, a TIGIT, a VISTA, a VTCN1, a CD2, a CD20, a CD30, a CD33, a CD52, a CD70, a CD112, a CD160, and a CD226 molecule;(b) extracorporeally removing an immunological blocking factor that inhibits the effectiveness of the antibody from blood or a blood component of the patient.20. The method of claim 19 , wherein the antibody is selected from a group consisting of IMP321 claim 19 , ibritumomab tiuxetan claim 19 , ofatumumab claim 19 , rituximab claim 19 , obinutuzumab claim 19 , tositumomab claim 19 , brentuximab vedotin claim 19 , gemtuzumab ozogamicin claim 19 , and alemtuzumab.21. The method of claim 19 , wherein the immunological blocking factor is a soluble tumor necrosis factor (TNF)-alpha receptor.22. The method of claim 21 , wherein step (b) is performed using an affinity capture substrate that comprises an immobilized TNF-alpha molecule comprising one or more of a native TNF-alpha molecule and a mutated TNF-alpha molecule.23. The method of claim 22 , wherein the immobilized TNF- ...

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10-02-2022 дата публикации

INCREASING RESPONSES TO CHECKPOINT INHIBITORS BY EXTRACORPOREAL APHERESIS

Номер: US20220041732A1
Принадлежит: IMMUNICOM, INC.

The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway. 118-. (canceled)19. A method of enhancing an efficacy of an antibody administered to a patient , comprising the steps of:(a) administering an antibody capable of suppressing activity of a CTLA-4 molecule; and(b) extracorporeally removing an immunological blocking factor that inhibits the effectiveness of the antibody from blood or a blood component of the patient.20. The method of claim 19 , wherein the antibody is selected from the group consisting of ipilimumab claim 19 , tremelimumab claim 19 , and BNI3.21. The method of claim 19 , wherein the immunological blocking factor is a soluble tumor necrosis factor (TNF)-alpha receptor.22. The method of claim 21 , wherein step (b) is performed using an affinity capture substrate that comprises an immobilized TNF-alpha molecule comprising one or more of a native TNF-alpha molecule and a mutated TNF-alpha molecule.23. The method of claim 22 , wherein the immobilized TNF-alpha molecule is a trimer.24. The method of claim 19 , further comprising after step (b) administering an antibody capable of suppressing activity of a CTLA-4 molecule one or more additional times to the patient.25. The method of claim 19 , further comprising after step (b) extracorporeally removing one or more additional times an immunological blocking factor that inhibits the effectiveness of the antibody from blood or a blood ...

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02-02-2017 дата публикации

Five-Port Blood Separation Chamber And Methods Of Using The Same

Номер: US20170028122A1
Автор: Min Kyungyoon
Принадлежит:

Systems and methods are provided for separating blood into two or more separated blood components. The system includes a blood separation chamber with a single stage having five ports connected thereto. The five ports include a blood inlet port, a red blood cell outlet port, a platelet-rich plasma outlet port, a platelet-poor plasma outlet port, and a buffy coat outlet port. In the single stage, blood may be separated into a variety of components, such as red blood cells and platelet-rich plasma or red blood cells, platelet-poor plasma, and buffy coat. Depending on the components into which the blood is to be separated, flow out of one or more of the outlet ports may be prevented. 1. A blood separation chamber , comprising:a single stage defined by an inner wall including a perimeter and an outer wall including a perimeter, wherein the inner and outer walls are joined along at least a portion of the perimeters of the inner and outer walls;a blood inlet port connected to the single stage;a red blood cell outlet port connected to the single stage;a platelet-rich plasma outlet port connected to the single stage;a platelet-poor plasma outlet port connected to the single stage; anda buffy coat outlet port connected to the single stage.2. The blood separation chamber of claim 1 , wherein a portion of the inner and outer walls adjacent to the blood inlet port is comprised of a flexible material.3. The blood separation chamber of claim 1 , wherein a portion of the inner and outer walls adjacent to the red blood cell outlet port is comprised of a rigid material.4. The blood separation chamber of claim 1 , whereinthe inner and outer walls are joined at first and second lateral edges of the perimeters,the blood inlet and platelet-rich plasma outlet ports are connected to the single stage adjacent to the first lateral edge, andthe red blood cell, platelet-poor plasma, and buffy coat outlet ports are connected to the single stage adjacent to the second lateral edge.5. The blood ...

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04-02-2016 дата публикации

METHODS AND DEVICES FOR REMOVAL OF IMMUNOSUPPRESSIVE LIGANDS

Номер: US20160030659A1
Автор: CHENEY Ian Wayne
Принадлежит:

The present disclosure relates to methods of removing soluble NKG2D ligands, including soluble MICA, soluble MICB and soluble ULBP proteins, from blood to treat diseases characterized by abnormal levels of soluble NKG2D ligands. Further provided are systems and devices for carrying out the therapeutic methods. 160-. (canceled)61. A method of treating a subject afflicted with a disease characterized by elevated levels of a soluble NKG2D (sNKG2D) ligand , the method comprising:(a) contacting the subject's blood or plasma fraction of the blood extracorporeally with a binding agent which binds specifically to the sNKG2D ligand;(b) separating the blood or plasma fraction from complexes of binding agent and sNKG2D ligand; and(c) reinfusing the blood or the plasma fraction to the subject.62. The method of claim 61 , wherein the plasma fraction of the blood is contacted with the binding agent.63. The method of claim 61 , wherein the sNKG2D ligand comprises a soluble MICA (sMICA) and/or soluble MICB (sMICB) protein claim 61 , and the binding agent binds specifically to sMICA and/or sMICB.64. The method of claim 63 , wherein the binding agent comprises an antibody which binds specifically to sMICA and/or sMICB.65. The method of claim 64 , wherein the antibody binds specifically to the alpha-1 domain claim 64 , alpha-2 domain claim 64 , and/or alpha-3 domain of the sMICA or sMICB.66. The method of claim 65 , wherein the antibody binds specifically to an epitope on the alpha-3 domain of MICA or MICB but does not bind specifically to full length MICA or MICB or extracellular domain of membrane bound form of MICA or MICB.67. The method of claim 64 , wherein the antibody comprises a polyclonal antibody claim 64 , monoclonal antibody claim 64 , chimeric antibody claim 64 , humanized antibody claim 64 , fully human antibody claim 64 , single chain antibody claim 64 , multispecific antibody claim 64 , or combinations thereof.68. The method of claim 61 , wherein the binding agent is ...

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04-02-2016 дата публикации

SYSTEMS AND METHODS FOR PARALLEL CHANNEL MICROFLUIDIC SEPARATION

Номер: US20160030660A1
Принадлежит:

The present disclosure describes a system and method for microfluidic separation. More particularly, the disclosure describes a system and method for the purification of a fluid by the removal of undesired particles. The device includes microfluidic separation channels that include multiple outlets. The device also includes isolation slots positioned between each of the microfluidic separation channels. The device's base includes multiple acoustic transducers which in some implementations are configured to protrude into the isolation slots. The acoustic transducers are configured to generate aggregation axes within the separation channels, which are used to separate out undesired particles. 1. A separation device comprising: a plurality of microfluidic separation channels each having an upstream portion and a downstream portion, the upstream portion comprising an inlet and the downstream portion comprising at least a first outlet and a second outlet; and', 'one or more isolation slots, one of the one or more isolation slots positioned between each of the plurality of microfluidic separation channels; and, 'a plastic substrate defininga base substrate coupled to the plastic substrate and comprising one or more acoustic transducers, each of the one or more acoustic transducers coupled to a wall of one or more of the respective plurality of microfluidic separation channels.2. The device of claim 1 , wherein each of the one or more acoustic transducers protrude perpendicular to a face of the base substrate and into a respective one of the one or more isolation slots.3. The device of claim 1 , wherein the first outlet of each of the plurality of microfluidic separation channels is positioned substantially along a longitudinal axis of the respective microfluidic separation channel.4. The device of claim 1 , wherein the second outlet of each of the plurality of microfluidic separation channels is positioned adjacent to a wall of the respective microfluidic separation ...

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04-02-2016 дата публикации

Blood separation container for extracting self-platelet

Номер: US20160030661A1
Автор: Eui Jae HWANG
Принадлежит: GOOD MORNING BIO CO Ltd

The present invention relates to a blood separation container for extracting self-platelet. According to the present invention, since a second coupling portion is formed at a release prevention member coupled to a lower portion of a main body in a PRP separation container, and an ascending member having a bolt structure is screwed to the second coupling portion to ascend a lower cover disposed in a lower fluid chamber of the main body, a separate second main body is unnecessary unlike the related art. Therefore, the PRP separation container is easy to carry, manufacturing costs can be reduced to thereby ensure competitive price, and a PRP can be easily separated and extracted.

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01-02-2018 дата публикации

Oil separator

Номер: US20180029045A1
Автор: Kosaku Ishida
Принадлежит: Tokyo Roki Co Ltd

An oil separator separating mist oil from processing-target gas includes: a case, a first partition wall and a lower, second partition wall, both partitioning vertically an internal space of the case; a partition dividing a space between the first and second partition walls into an introduction path and a first chamber; a supply hole vertically penetrating the second partition wall from the introduction path to a separation chamber; a communication hole vertically penetrating the second partition wall from the first chamber to the separation chamber; a rotor in the separation chamber; a center-side space in a center part of the rotor, the center-side space communicating with the supply hole through an open, upper part of the center-side space. The rotor separates the mist oil from the processing-target gas flowing from the center-side space to an outer periphery of the rotor, where the separated oil is emitted. The processing-target gas flows into the first chamber through the communication hole.

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01-02-2018 дата публикации

SEPARATION DISK AND OIL SEPARATOR

Номер: US20180029046A1
Автор: ISHIDA Kosaku
Принадлежит: TOKYO ROKI CO., LTD.

An oil separator that separates mist oil from processing-target gas containing mist liquid includes a plurality of separation disks. The plurality of separation disks rotate around an axis, and are stacked and spaced in an axial direction. The separation disk includes an inner peripheral part and an outer peripheral part. The inner peripheral part forms a surface of a frustum of a hypothetical cone or pyramid coaxial with the separation disk, and is inclined with respect to a radial direction toward one side in an axial direction. The outer peripheral part forms a surface of a frustum of a hypothetical cone or pyramid coaxial with the separation disk, and continuously extends outward from an outer peripheral edge of the inner peripheral part. The outer peripheral part is inclined with respect to the radial direction toward another side in the axial direction. 1. A separation disk that rotates around an axis to capture mist oil contained in processing-target gas ,the separation disk comprising: 'the inner peripheral part being inclined with respect to a radial direction toward one side in an axial direction; and', 'an inner peripheral part forming a surface of a frustum of a hypothetical cone or pyramid coaxial with the separation disk,'} the outer peripheral part continuously extending outward from an outer peripheral edge of the inner peripheral part,', 'the outer peripheral part being inclined with respect to the radial direction toward another side in the axial direction., 'an outer peripheral part forming a surface of a frustum of a hypothetical cone or pyramid coaxial with the separation disk,'}2. The separation disk according to claim 1 , whereina corner portion interposed between the inner peripheral part and the outer peripheral part has a right angle or an obtuse angle.3. The separation disk according to claim 1 , whereinan inclined angle of the inner peripheral part with respect to the radial direction is 45° or less.4. The separation disk according to ...

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02-02-2017 дата публикации

SEPARATION SYSTEM

Номер: US20170029762A1
Принадлежит:

This invention is about a separation system () that effectively separates the biological material into its different components with the effect of centrifugal force and performs processes such as separation of stem cells from bone marrow or fatty tissue with ease. 11. A separation system () which separates and evaluates biological material into different components by means of centrifugal force , and also is basically characterized by ,{'b': '2', 'At least one kit () in which the biological material is evaluated, distributed and preserved,'}{'b': 1', '2, 'At least one separation chamber (.) in which the biological material is placed and separated,'}{'b': 1', '1', '2', '1', '2', '2', '1', '2', '1', '2', '2, 'At least one transfer tube (.) that is between the kit () and the chamber (.) and transfers the raw biological material from the kit () to the chamber (.) and the separated biological material from the container (.) to the kit (),'}{'b': 1', '4', '1', '2', '2', '1', '1', '2', '1', '2', '2', '2, 'At least one piston (.) that is in the chamber (.) and transfers the biological material from the initial container (.) into the container (.) by means of vacuum and pressure created in the environment, that also transfers the separated components from the container (.) to the product container (.) by creating pressure in the environment,'}{'b': 1', '13', '1', '2, 'At least one motor (.) on which the chamber (.) pivots in order to separate the biological material by means of centrifugal force,'}{'b': 1', '23', '1', '13, 'At least one shock absorber (.) that absorbs and dissipates the vibration of the motor (.) and ensures its quite operation,'}{'b': 1', '22', '1', '2, 'At least one volume detector (.) that is in the chamber (.) and determines the volume of the biological material,'}{'b': 1', '19', '1', '1', '1', '2', '2', '2, 'At least one product sensor (.) that is on the transfer tube (.) and identifies and differentiates between the biological material that is ...

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31-01-2019 дата публикации

RADIAL COUNTERFLOW SEPARATION FILTER WITH FOCUSED EXHAUST

Номер: US20190030474A1
Автор: McCutchen David J.
Принадлежит:

An improved apparatus for filtration has a fluid mixture feed comprising light and heavy fractions fed into the workspace between counter-rotating disk impellers within a tank, thereby forming vortices in the workspace. A static radial exhaust array is located axially in the workspace, comprising exhaust channels, each of which has a peripheral end facing the workspace and an inner end communicating with an axial exhaust drain. An axial pump produces low pressure in the axial exhaust drain, thereby drawing in and anchoring the vortices to the peripheral ends of the exhaust channels so that the exhaust channels can extract the contents of the vortex cores. Vanes can be incorporated into the workspace surface of each disk impeller so that the opposed vanes pass in close proximity, forming vortices along a plurality of radial lanes of intersection, with the peripheral openings of each of the exhaust channels aligned with at least one of the lanes of intersection in the workspace. The feed can be a peripheral feed which enters the workspace radially inward through the periphery of the workspace, or the feed can enter the workspace radially outward through a static axial feed array. 1. An apparatus for filtration comprising:a fluid mixture feed comprising light and heavy fractions, fed into a tank;at least one pair of disk impellers within the tank, arranged in parallel and defining a workspace between them, the disk impellers capable of coaxial counter-rotation as the feed enters the workspace to form vortices in the fluid mixture in the workspace;one or more motors coupled to the disk impellers to produce said counter-rotation;a static radial exhaust array located axially in the workspace between the disk impellers and approximately centered on an axis of rotation of the disk impellers, said exhaust array comprising exhaust channels, each channel having a peripheral end facing the workspace and an inner end communicating with an axial exhaust drain; andan axial pump to ...

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30-01-2020 дата публикации

Systems And Methods For Platelet Filtration Using An Additive

Номер: US20200030503A1
Принадлежит:

Systems and methods are provided for collecting a platelet product from a fluid including platelets and plasma. Platelet-rich plasma is separated from at least a portion of another constituent of the fluid and then may be further separated into concentrated platelets and platelet-poor plasma, with the concentrated platelets being resuspended. Separated platelets (in the form of platelet-rich plasma or resuspended platelets) are conveyed through a size exclusion filter and into a platelet storage container. The size exclusion filter is configured to remove platelet clumps and/or particles larger than a platelet from the separated platelets. Subsequently, an additive is conveyed through the size exclusion filter and into the platelet storage container. Conveying additive through the size exclusion filter improves platelet recovery in the platelet product by displacement of separated platelets with the additive and may also break up any platelet clumps that are present in the size exclusion filter. 1. A disposable processing circuit configured for use in combination with a reusable hardware apparatus including a separation device , the processing circuit comprising:a processing chamber configured to receive a fluid including plasma and platelets and associable with a separation device of a reusable hardware apparatus for separation of platelets from at least a portion of another constituent of a fluid including plasma and platelets;a size exclusion filter in downstream fluid communication with the processing chamber and configured to remove platelet clumps from separated platelets conveyed therethrough from the processing chamber;a platelet storage container in downstream fluid communication with the size exclusion filter and configured to receive filtered platelets from the size exclusion filter; andan additive container in upstream fluid communication with the size exclusion filter.2. The disposable processing circuit of claim 1 , further comprising a cassette claim ...

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30-01-2020 дата публикации

BLOOD COMPONENT COLLECTION CASSETTE AND MANUFACTURING METHOD OF THE SAME

Номер: US20200030504A1
Автор: IGARASHI Masatsugu
Принадлежит: TERUMO KABUSHIKI KAISHA

A blood component collection cassette that can trap a foreign object such as a blood-coagulated clot from blood components to be returned to a blood donor and a manufacturing method of the blood component collection cassette are provided. 1. A blood component collection cassette which includes a cassette main body , where a flow path is formed , and is configured to be mountable to a blood component separation device , whereina sheet-shaped filter member for trapping a substance where blood components coagulate is arranged on the flow path in the cassette main body,the cassette main body has a filter housing unit that houses the filter member,a first tube having an inner cavity communicating with an inner space of the filter housing unit and a second tube having an inner cavity communicating with the inner space at a position different from a position where the first tube communicates with the inner space are arranged in the cassette main body, andthe inner space is separated by the filter member into a first space on the side of the first tube and a second space on the side of the second tube.2. The blood component collection cassette according to claim 1 , whereinthe cassette main body has a first sheet and a second sheet which are formed of a soft material, the first sheet and the second sheet are superposed in a thickness direction and bonded to each other, and the flow path is formed between the first sheet and the second sheet.3. The blood component collection cassette according to claim 2 , whereinthe filter member has a first region arranged between the first sheet and the first tube and a second region arranged between the second sheet and the second tube.4. The blood component collection cassette according to claim 3 , whereinthe first tube and the second tube are arranged to face each other through the inner space.5. The blood component collection cassette according to claim 4 , whereinthe first region is provided at one end portion of the filter member ...

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30-01-2020 дата публикации

BLOOD COMPONENT COLLECTION CASSETTE AND MANUFACTURING METHOD OF THE SAME

Номер: US20200030505A1
Автор: IGARASHI Masatsugu
Принадлежит: TERUMO KABUSHIKI KAISHA

A blood component collection cassette that can trap a substance where blood components coagulate by using a simple and economical configuration, and a manufacturing method of the blood component collection cassette are provided. 1. A blood component collection cassette which includes a cassette main body , where a flow path is formed , and is configured to be mountable to a blood component separation device , whereinthe cassette main body is formed of a soft material, anda filter member for trapping a substance where blood components coagulate is arranged on the flow path in the cassette main body.2. The blood component collection cassette according to claim 1 , whereinthe cassette main body has a filter housing unit that houses the filter member, andthe filter member is fixed to an inner circumferential portion of the filter housing unit.3. The blood component collection cassette according to claim 1 , whereinthe cassette main body has a first sheet and a second sheet which are formed of a soft material, the first sheet and the second sheet are superposed in a thickness direction and bonded to each other, and the flow path is formed between the first sheet and the second sheet.4. The blood component collection cassette according to claim 3 , whereinan engaging portion attachable to and detachable from a distal end portion of a blow nozzle which is used when the cassette main body is blow-molded is provided to the filter member.5. The blood component collection cassette according to claim 1 , whereinan engaging portion attachable to and detachable from a distal end portion of a tool which is used when the cassette main body is formed is provided to the filter member.6. The blood component collection cassette according to claim 4 , whereinthe filter member has a cylindrical filter main body of which one end is provided with an opening portion and of which another end is provided with a bottom portion, andthe engaging portion protrudes from the other end of the filter ...

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09-02-2017 дата публикации

A centrifugal separator having an outlet opening opposite a stack of separation disks

Номер: US20170036220A1
Автор: Thomas Eliasson
Принадлежит: ALFA LAVAL CORPORATE AB

A centrifugal separator for cleaning gas containing liquid impurities includes a stationary casing, enclosing a separation space through which a gas flow is permitted. The stationary casing includes a surrounding side wall, a first end wall and a second end wall. An inlet extends through the stationary casing and permits supply of the gas to be cleaned. A rotating member includes a stack of separation disks rotatable around an axis of rotation. A drive member rotates the rotating member. A gas outlet permits discharge of cleaned gas, and includes an outlet opening through the side wall. A drainage outlet permits discharge of liquid impurities separated from the gas. The outlet opening is positioned opposite to the stack of separation disks.

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09-02-2017 дата публикации

A CENTRIFUGAL SEPARATOR HAVING A DRAINAGE OUTLET IN AN UPSTREAM PORTION OF THE GAS OUTLET

Номер: US20170036221A1
Автор: Eliasson Thomas
Принадлежит: ALFA LAVAL CORPORATE AB

A centrifugal separator for cleaning a gas containing liquid impurities includes a stationary casing, enclosing a separation space and a surrounding side wall, a first end wall and a second end wall. An inlet extends through the stationary casing and permits supply of the gas to be cleaned. A rotating member includes a stack of separation disks rotatable around an axis of rotation by means of a drive member. A gas outlet permits discharge of cleaned gas and comprises an outlet opening through the stationary casing and an upstream portion extending from the outlet opening. A drainage outlet permits discharge of liquid impurities separated from the gas. The drainage outlet is provided in the gas outlet downstream the upstream portion. The gas outlet conveys the liquid impurities to the drainage outlet. 116-. (canceled)17. A centrifugal separator for cleaning a gas containing liquid impurities , the centrifugal separator comprising:a stationary casing, enclosing a separation space through which a gas flow is permitted, the stationary casing comprising a surrounding side wall, a first end wall and a second end wall;an inlet extending through the stationary casing and permitting supply of the gas to be cleaned;a rotating member comprising a stack of separation disks and being arranged to rotate around an axis of rotation;a drive member, for rotating the rotating member;a gas outlet configured to permit discharge of cleaned gas, wherein the gas outlet comprises an outlet opening through the stationary casing and an upstream portion extending from the outlet opening;a drainage outlet configured to permit discharge of liquid impurities separated from the gas; andthe drainage outlet being provided in the gas outlet downstream the upstream portion, wherein the gas outlet is configured to convey the liquid impurities to the drainage outlet.18. The centrifugal separator according to claim 17 , wherein the gas outlet comprises an outlet conduit having an entry portion provided ...

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08-02-2018 дата публикации

CENTRIFUGE WITH EXCHANGEABLE ROTORS

Номер: US20180036694A1
Принадлежит:

The invention relates to a dual centrifuge () which has the following: a driveshaft (), a rotor (), which is mounted on the driveshaft () and which can be removed axially in a removal direction (E), for a dual centrifuge, having at least one rotational unit (); an opening () in the rotor (), wherein an end region () of the driveshaft () at least engages into said opening; and an additional drive mechanism () for the rotational unit or the rotational units (). The dual centrifuge additionally has a design for operating various additional types of rotors; however, only one rotor () can be arranged on the driveshaft () at all times. The various rotor types () are also adapted to the additional drive mechanism () for the rotational units () such that the function is not adversely affected. The invention is characterized by a design for operating at least one angular head rotor () and a swing-out rotor (). For this purpose, the driveshaft () and the various rotor types () are adapted to each other. The bearing (), the driveshaft (), and the various rotor types () are adapted to one another such that each non-dual rotor () has a geometry that is measured such that when the rotor () is mounted, a drive means () of the additional drive mechanism () for the rotational units () is arranged so as to not contact the mounted rotor (). 1. Dual centrifuge , comprisinga) driveshaft,b) a dual centrifuge rotor which is mounted on the driveshaft and which can be removed axially in a removal direction, having at least one rotational unit,c) an opening in the rotor which is at least engaged by an end portion of the driveshaft, andd) an additional drive mechanism for the one or plural rotational unit,{'b': '16', 'e) a design for operating various additional types of rotors, in which only one rotor can be arranged on the driveshaft () at a time, and in which the various rotor types are also adapted to the additional drive mechanism for the rotational units such that the function is not ...

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18-02-2021 дата публикации

SYSTEM, METHOD AND CONTROLLER FOR RECOVERY OF CONCENTRATED PARTICLES SUSPENDED IN FLUID

Номер: US20210046489A1
Принадлежит:

Embodiments provide a fluid recovery system and method for use with concentrator systems for concentrating particles suspended in a fluid and where this suspension is recovered from a fluid stream drawn from the concentrator system. A controller is configured to control valve actuation to direct concentrate being drawn from the concentrator chamber through a recovery tube to a recovery reservoir based on fluid volume movement. The system can use a density sensor to detect density transitions in fluid in the fluid recovery tube to identify leading and trailing edges of a portion of concentrated particles in fluid suspension passing through the recovery tube and actuate recovery valves based on objectives for maximising particle recovery with minimal dilution. 149-. (canceled)50. A fluid recovery system configured to operatively engage with a concentrator apparatus comprising a concentrating chamber having a first fluid path and a second fluid path connected in line with a pumping mechanism , whereby to recover concentrated fluid from the concentrating chamber fluid enters the concentrating chamber via the first fluid path as fluid exits the concentrating chamber via the second fluid path to a fluid recovery tube , and a recovery valve assembly and valve actuator configured to switch flow of fluid from the fluid recovery tube one of two or more output fluid tubes , at least one fluid output tube providing a fluid capture path and at least one fluid output tube providing a non-capture path; a density sensor configured to detect density of fluid in the recovery tube preceding the recovery valve assembly when operatively engaged with the concentrator apparatus; and', monitor operation of the fluid pumping mechanism to determine dynamic fluid volume movement of fluid in the fluid recovery tube,', a first density transition in fluid in the fluid recovery tube from a first density to second density, the second density being higher than the first density, the density ...

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16-02-2017 дата публикации

Suspension Jig and Method for Transporting Additive Solution

Номер: US20170043071A1
Автор: Imai Tadashi
Принадлежит: TERUMO KABUSHIKI KAISHA

A hanging device (A) used in an additive solution transfer method includes an upper hanging section () and a support mechanism (lower hanging section ()). The upper hanging section () is used to hang a medical fluid bag () upside down. The support mechanism (lower hanging section ()) supports a primary bag () or a transfer line () in a predetermined state such that, when a red blood cell preservation liquid (M) is transferred from the medical fluid bag () to the primary bag () using the height difference between the primary bag () and the medical fluid bag (), air from the medical fluid bag () is stopped in the middle of the transfer line (). 1. Hanging devices configured to hang a blood bag system comprising:a first bag containing a blood component;a second bag containing additive solution; and a transfer line that forms a flow path between the first bag and the second bag,the hanging devices comprising:a second bag hanging section configured to hang the second bag such that a influx portion of the second bag faces downward; andsupport mechanisms configured to support the first bag or the transfer line in a predetermined state such that, when the additive solution is transferred from the second bag to the first bag using a height difference between the first bag and the second bag, air from the second bag stops in the middle of the flow path.2. The hanging device according to claim 1 ,{'b': '54', 'wherein the support mechanism hangs the first bag such that a influx portion of the first bag faces downward at a position lower than the second bag () hung by the second bag hanging section.'}3. The hanging device according to claim 1 ,wherein the support mechanism supports the first bag diagonally with respect to a horizontal direction to arrange the first bag to be gradually lowered toward the flux portion of the first bag at a position lower than the second bag hung by the second bag hanging section.4. The hanging devices according to claim 2 ,wherein the transfer ...

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16-02-2017 дата публикации

Centrifugation System With Red Blood Cell Barrier

Номер: US20170043080A1
Принадлежит:

Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port. 114-. (canceled)15. A method of centrifugally separating blood components from blood , comprising:flowing blood into a first stage of a multiple-stage separation chamber, the first stage having a plasma outlet port and a red cell outlet port;rotating the separation chamber about a rotational axis so as to separate the blood into a separated blood component substantially comprising plasma and a blood component substantially comprising red blood cells;flowing the separated blood components along a path toward the plasma outlet port, wherein the path toward the plasma outlet port includes a first projection which is oriented to impede the separated blood component substantially comprising red blood cells from flowing into the plasma outlet port; and the path toward the red cell outlet port includes a second projection which is oriented to impede the separated blood component substantially comprising plasma from flowing into the red cell outlet port, and', 'one end of the first projection is substantially aligned with one end of the second projection along a radius passing ...

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16-02-2017 дата публикации

Continuous Flow Centrifuge For Fluid Separation Or Water Desalination And Purification

Номер: US20170043357A1
Автор: Sherman Karl Lee
Принадлежит:

In an embodiment, a continuous flow centrifuge for water desalination comprises a double walled enclosure casing having a water egress and ingress. The centrifuge rotates around a central axis, which a rotor extends through wherein one or more main ball bearings and one or more thrust roller bearings aid in the rotation. Extending from the rotor is a plurality of radial flow chambers terminating in one or more circumferential drain openings allowing for the selective expulsion of fluid. Pluralities of channel divider discs extend from the rotor and are between the radial flow chambers. A fluid outlet is connected to an egress of the centrifuge. A pump impeller is positioned at the egress wherein water is pulled through the ingress. 1. A continuous flow centrifuge comprising:a. a double-walled enclosure casing having a water ingress, a water egress and central axis, and defining a plurality of radial flow chambers;b. one or more circumferential drain apertures positioned at the outer circumference of the radial flow chambers;c. a rotor extending through the central axis of the centrifuge connected to the centrifuge;d. a plurality of channel divider discs extending outwardly from the rotor;e. a fluid outlet connected to an egress of the centrifuge.2. The continuous flow centrifuge of claim 1 , wherein the channel divider discs are each positioned within a radial flow chamber claim 1 , and are adapted to rotate around the axis within the radial flow chambers.3. The continuous flow centrifuge of further comprising one or more O-ring seals at a plurality of connections within the centrifuge.4. The continuous flow centrifuge of further comprising one or more main ball bearings integrated to support the centrifuge and aid in rotation of the centrifuge.5. The continuous flow centrifuge of further comprising one or more thrust roller bearings to further aid in the rotation of the device.6. The centrifuge of further comprising a pump impeller positioned at the egress to pull ...

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15-02-2018 дата публикации

PARTICLE SEPARATING SYSTEM

Номер: US20180043374A1
Автор: Bohner Jürgen, Meinig Uwe
Принадлежит:

A particle separating system for supplying a cam shaft phase adjuster with cleaned lubricating oil. The phase adjuster includes a stator, a rotor connectable to a cam shaft, and a control valve for hydraulically adjusting the rotational angular position of the rotor relative to the stator. The particle separating system includes an oil separator arranged in the flow of the lubricating oil, upstream of an oil gallery of an engine supplied with the lubricating oil, exhibiting a separation efficiency of at least 50% for particles having a size P and a separation efficiency of at least 90% at a size P>P a particle separator arranged downstream of the oil separator and upstream of the phase adjuster or control valve, to clean the lubricating oil for the phase adjuster. The particle separator exhibits a separation efficiency of 50% at a size P where PP; and a particle separator which is arranged downstream of the main oil separator and upstream of the cam shaft phase adjuster or control valve, in order to clean the engine lubricating oil for the cam shaft phase adjuster,'}{'b': 3', '1', '3, 'wherein the particle separator exhibits a separation ...

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14-02-2019 дата публикации

SYSTEMS AND METHODS FOR MONITORING A FLUID PROCEDURE USING HYDROSTATIC PRESSURE

Номер: US20190046710A1
Принадлежит:

A computer-implemented method comprises providing a fluid circuit comprising fluid pathways configured to mount and associate with a durable processing device comprising a pressure sensor in communication with a controller and a fluid pathway. A container is connected to the pressure sensor and may receive a volume of fluid. A change in pressure values between a first and second time is measured from when the volume of fluid is not in communication with the pressure sensor to when the volume of fluid is in communication with the pressure sensor, the volume of fluid within the container or a presence or absence of a fluid connection to the fluid pathway based on the change in pressure values is determined, and a response action is executed if the volume of fluid within the container is not within an authorized volume range for the time period, or if a fluid connection is unauthorized. 1. A fluid processing system for monitoring fluid flow in a medical fluid procedure , comprising:a fluid circuit comprising a plurality of fluid pathways configured to mount and associate with a durable processing device controlled by a programmable controller, wherein the durable processing device comprises a pressure sensor in communication with the programmable controller and a fluid pathway;a container part of the fluid circuit configured for fluid communication with the pressure sensor and configured to receive a volume of fluid; initiate a phase of the medical fluid procedure associated by the controller with a plurality of ranges of pressure values authorized at specific times for the pressure sensor;', 'receive a first pressure value from the pressure sensor measured at a first time during the phase when the volume of fluid is not in fluid communication with the pressure sensor;', 'receive a second pressure value from the pressure sensor measured at a second time during the phase when the volume of fluid is in fluid communication with the pressure sensor;', 'compare a difference ...

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14-02-2019 дата публикации

Liquid-liquid contact device and liquid-liquid contact method

Номер: US20190046896A1
Принадлежит: Kobe Steel Ltd

A liquid-liquid contact device includes: an internal casing surrounding an inner chamber for providing countercurrent contact between a light liquid and a heavy liquid; an external casing surrounding the internal casing so as to form an outer chamber around the internal casing; a light liquid introduction tube guiding the light liquid to the inner chamber; and a heavy liquid introduction tube guiding the heavy liquid to the inner chamber. The internal casing has an upper opening and a lower opening which opens at a location below the upper opening. The external casing has a heavy liquid discharge outlet through which the heavy liquid is allowed to be discharged from the outer chamber, and a light liquid discharge outlet which is disposed above the heavy liquid discharge outlet and through which the light liquid is allowed to be discharged from the outer chamber.

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14-02-2019 дата публикации

ISOLATION TUBE

Номер: US20190046975A1
Принадлежит:

A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample. 1. An assembly comprising:a retainer within a body of a separation container comprising an annular wall defining a central opening; anda plunger comprising a longitudinal member defining a longitudinal axis; andwherein the central opening of the retainer is configured to receive the plunger therethrough; andwherein the retainer is configured to releasably engage the plunger to hold the plunger at a predetermined position.2. The assembly of claim 1 , wherein the retainer further comprises at least one retaining member claim 1 , wherein the plunger further comprises at least one locking member claim 1 , and wherein the at least one retaining member of the retainer is configured to releasably engage the at least one locking member of the plunger.3. The assembly of claim 2 , wherein the at least one retaining member comprises at least one support projection extending from the annular wall claim 2 , wherein the at least one retaining member is configured to engage the plunger.4. The assembly of claim 3 , wherein the annular wall defines a circumferential direction in a plane spanning the central opening and oriented about the central opening and an axial direction oriented perpendicular to the plane claim 3 , and wherein the at least one support projection defines a circumferential wall that is longer in the ...

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14-02-2019 дата публикации

ISOLATION TUBE

Номер: US20190046976A1
Принадлежит:

A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample. 1. An assembly comprising: a body, the body defining an internal chamber, wherein the body defines an opening at a first end, and wherein the body is configured to receive a sample within the internal chamber; and', 'a seal attached to the body and disposed across the opening, wherein the seal is configured to seal the opening of the body; and, 'a separation container comprisingan end cap disposed at the first end of the body and removably connected to the body, wherein the seal is positioned between the end cap and the body.2. The assembly of claim 1 , wherein the body further defines an annular surface around the opening claim 1 , and wherein the seal is attached to the annular surface.3. The assembly of claim 2 , wherein the end cap defines a support surface configured to be positioned parallel to the annular surface of the body with the seal being disposed between the support surface and the annular surface.4. The assembly of claim 1 , wherein the seal comprises a membrane.5. The assembly of claim 4 , wherein the seal comprises a foil sheet.6. The assembly of claim 1 , wherein the seal is welded to the body of the separation container.7. The assembly of claim 1 , wherein the end cap is a centrifuge adapter comprising at least one of a flat distal end and a tapered portion configured to engage a ...

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14-02-2019 дата публикации

ISOLATION TUBE

Номер: US20190046977A1
Принадлежит:

A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample. 1. A separation container comprising:a body defining an internal chamber, wherein the body defines a first opening at a first end and a second opening at a second end, and wherein the body is configured to receive a sample within the internal chamber;a seal disposed across the first opening, such that the seal is configured to seal the first opening of the body;a plunger movably disposed at least partially inside the internal chamber, wherein the plunger is configured to be actuated to open the seal and extract a portion of the sample; anda flexible sealing member at least partially covering the second opening, wherein at least a portion of the plunger is configured to extend at least partially into the flexible sealing member, such that compression of the flexible sealing member is configured to actuate the plunger.2. The separation container of claim 1 , wherein the flexible sealing member comprises a flange defining an annular surface configured to engage the body.3. The separation container of claim 2 , wherein the flexible sealing member further comprises a wall extending from the flange claim 2 , and wherein an angle between the flange and the wall is greater than or equal to 90 degrees when the flexible sealing member is in an unactuated position.4. The separation container of claim 3 , wherein ...

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25-02-2016 дата публикации

PARALLEL PROCESSING OF FLUID COMPONENTS

Номер: US20160051744A1
Принадлежит:

A kit for blood component processing comprising a fluid circuit into which blood is drawn, wherein the fluid circuit comprises a plurality of pathways; wherein the first pathway is configured to receive blood drawn from a blood source and leads to a separation device, wherein the separation device is configured to separate the blood into components; wherein the second pathway is configured to receive a first component from the separation device and transport at least a portion of the first component to a first processing device, wherein the first processing device may alter the first component to produce a first output; and wherein the third pathway is configured to receive a second component from the separation device and transport at least a portion of the second component to a second processing device, wherein the second processing device may alter the second component to produce a second output. 1. A disposable kit for blood component processing comprising:a fluid circuit into which blood is drawn from a blood source, wherein the fluid circuit comprises a first, second, and third pathway;wherein the first pathway is configured to receive blood drawn from the blood source and leads to a separation device, wherein the separation device is configured to separate the blood into two or more components;wherein the second pathway is configured to receive a first component from the separation device and transport at least a portion of the first component to a first processing device, wherein the first processing device is configured to alter the first component in at least one of volume, constitution, and composition, to produce a first output; andwherein the third pathway is configured to receive a second component from the separation device and transport at least a portion of the second component to a second processing device, wherein the second processing device is configured to alter the second component in at least one of volume, constitution, and composition, to ...

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25-02-2016 дата публикации

MEDICAL SOLUTION AUTHENTICATION

Номер: US20160051746A1
Принадлежит:

A system of authenticating a medical solution used in a blood processing procedure, comprising a blood processing system having a user interface and access to a database of medical solutions identifiable by identifiers, wherein the blood processing system guides a user through steps of the procedure and the user interface prompts the user to execute an action as part of a step; a fluid circuit having an inlet for a medical solution, wherein the fluid circuit is coupled to the fluid processing system; wherein a step of the blood processing procedure comprises drawing a solution into the circuit, wherein the interface receives a user input of an identifier of the solution prior to the fluid processing system executing the step; wherein the fluid processing system is configured to compare the received identifier to medical solution identifiers within the database and, based on a result of the comparison, executing the step. 1. A blood processing system , comprising:a blood processing device having a user interface and a memory;a database of medical solutions identifiable by identifiers;a fluid circuit for use with the blood processing device having an inlet for a medical solution;wherein the blood processing device is configured to guide a user through one or more steps of a blood processing procedure including prompting a user to input an identifier of a medical solution, compare the identifier to information within the database, and authorize use of the medical solution upon verification of the identifier within the database.2. The system of claim 1 , wherein the fluid processing system is configured to alert the user via the user interface in the event that the medical solution is not an approved solution.3. The system of claim 1 , wherein the medical solution comprises at least one of an infusion solution claim 1 , blood additive solution claim 1 , anticoagulant solution claim 1 , saline solution claim 1 , blood component solution claim 1 , and replacement fluid.4. ...

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25-02-2021 дата публикации

SYSTEM AND METHODS FOR AUTOMATIC DILUTION OF WHOLE BLOOD TO INCREASE PLASMA CLARITY

Номер: US20210052805A1
Принадлежит:

A method and device are provided for centrifugally separating plasma from whole blood in which whole blood is introduced into a flow circuit having a blood access device connected to a first tubing for drawing whole blood from a blood source and for flowing whole blood to a centrifugal separation chamber; a volume of saline is added to the whole blood as it flows through the first tubing to dilute the whole blood; the volume of saline added to the whole blood is tracked; the whole blood having the volume of saline added thereto is separated in the centrifugal separation chamber so that an interface is created between the plasma and added saline and the cellular components of the whole blood; the separated plasma and added saline is flowed from the centrifugal separation chamber to a collection container; and a volume for the plasma and added saline in the collection container is determined. The device includes a programmable controller configured operate a first pump to flow saline from the container of saline through the second tubing segment to the first tubing segment, track a volume of saline flowed from the container of saline through the second tubing segment to the first tubing segment, flow separated plasma and added saline from the separation chamber through the third tubing segment to the collection container, and determine a volume for the plasma and added saline in the collection container. 1. A method for centrifugally separating plasma from whole blood comprising:a) introducing whole blood into a flow circuit having a blood access device connected to a first tubing for drawing whole blood from a blood source and for flowing whole blood to a centrifugal separation chamber;b) adding a volume of saline to the whole blood as it flows through the first tubing to dilute the whole blood;c) tracking the volume of saline added to the whole blood;d) separating the whole blood having the volume of saline added thereto in the centrifugal separation chamber whereby ...

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23-02-2017 дата публикации

METHODS AND SYSTEMS FOR PROCESSING AND WASHING A PHOTOPHERESIS MONONUCLEAR CELL PRODUCT

Номер: US20170049951A1
Принадлежит:

Methods and systems for the treatment and post-treatment processing of a mononuclear cell product are disclosed. The methods and systems include and provide for the separation of excess conditioning fluid and unbound treating agent prior to return of said treated mononuclear cell product to a patient. 1. A method for treating a cellular product in a cell therapy comprising:a) collecting a desired cellular product from a source of a biological fluid including desired cells in a unitary disposable fluid circuit;b) combining said cellular product with a conditioning solution in an amount effective to arrive at a desired dilution of the collected cell product for said treatment within said fluid circuit;c) combining said cellular product with a treating agent in an amount effective for said cell treatment within said fluid circuit;d) treating said cellular product to arrive at a treated product;e) introducing said treated product into a separation chamber of a separator;f) separating said treated product within said fluid circuit to arrive at a treated cell fraction and a supernatant fraction; andg) directing said treated cell fraction through said fluid circuit to a patient.2. The method of comprising separating said treated product by centrifugation.3. The method of comprising processing said treated product in a separation chamber by centrifugation and establishing an interface during said centrifugation between said treated cell fraction and a supernatant fraction.4. The method of comprising detecting the location of the interface within said chamber.5. The method of comprising commencing directing said treated cell fraction to said patient upon detection of the interface at a selected location.6. The method of comprising diverting said supernatant fraction to a waste container.7. The method of wherein said conditioning solution comprises saline.8. The method of further comprising combining said treated product with biological fluid and separating mononuclear cells ...

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08-05-2014 дата публикации

Continuous Flow Separation Chamber

Номер: US20140128239A1
Принадлежит: Haemonetics Corporation

A continuous flow centrifuge bowl includes a rotatable outer body, and a top and bottom core that are rotatable with the outer body. The bottom core has a wall extending proximally from a bottom wall. The proximally extending wall is radially outward from at least a portion of the top core and, together with the top core, defines a primary separation region in which initial separation of the whole blood occurs. The bowl may also have a secondary separation region located between the top core and the outer body, and a rotary seal that couples an inlet port and two outlet ports to the outer body. The inlet port may be connected to an inlet tube that extends distally into a whole blood introduction region. Additionally, one of the outlet ports may be connected to an extraction tube that extends into a region below the bottom core. 1. A centrifuge bowl for continuous separation of whole blood comprising:an outer body rotatable about a longitudinal axis of the centrifuge bowl, the outer body having a main body defining an interior cavity, a neck portion extending proximal to the main body, and a shoulder connecting the main body and the neck portion;a top core located within and rotatable with the outer body, the top core being coaxial with the outer body and including a chimney extending through the top core along the longitudinal axis of the centrifuge bowl;a separation region located between the top core and the outer body, rotation of the centrifuge bowl separating the whole blood within the separation region into a first blood component and a second blood component;an inlet port for introducing whole blood into the centrifuge bowl;an inlet tube fluidly connected to and extending distally from the inlet port and through the chimney, the inlet tube configured to introduce the whole blood into an introduction region;a first blood component outlet port for drawing a first blood component out of the centrifuge bowl;a first blood component extraction tube extending from ...

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23-02-2017 дата публикации

CENTRIFUGE AND SWING ROTOR FOR CENTRIFUGE

Номер: US20170050196A1
Автор: NEMOTO Kenichi, Sato Jun
Принадлежит: HITACHI KOKI CO., LTD.

The present invention provides a centrifuge comprising a lid section of a sample container, the lid section having a rotating shaft for swinging, and a swing-type rotor, and the centrifuge conducts centrifugation operation in a state where the sample container is seated in a bucket housing section by making the sample container in which the rotating shaft is mounted to a rotating shaft engagement groove of the rotor swing due to the rotation of the rotor. The rotating shaft comprises a plurality of members connected by a connection section and is configured so as to be bendable at the connection section by a centrifugal load accompanying the rotation of the rotor. 1. A centrifuge comprising a sample container , which comprises a rotating shaft for swing , and a swing type rotor , which comprises a through hole penetrating from an upper side to a lower side in an axial direction , a pair of support parts rotatably supporting two ends of the rotating shaft of the sample container mounted in the through hole , and a cutout part formed on a radial outer side in a direction perpendicular to a central axis of the through hole , and swinging the sample container with the rotating shaft mounted to the support parts by rotation of the rotor to perform a centrifugation operation in a state where the sample container is seated on the cutout part , wherein the rotating shaft comprises a plurality of members connected by a connection part and is bendable at the connection part by a centrifugal load that accompanies the rotation of the rotor.2. The centrifuge according to claim 1 , wherein after the sample container is swung by the rotation of the rotor claim 1 , the sample container is seated on the cutout part by bending of the rotating shaft at the connection part.3. The centrifuge according to claim 1 , wherein the sample container comprises a container part housing a sample and a lid part sealing the container part claim 1 , the container part comprises a seating surface to ...

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26-02-2015 дата публикации

APHERESIS PLATELETS WITH FIXED RESIDUAL PLASMA VOLUME

Номер: US20150056602A1
Принадлежит: Fenwal, Inc.

Methods and systems for obtaining platelets are disclosed. Platelets are collected in a pre-determined volume of plasma and a determined amount of a combined storage medium including the pre-determined amount of plasma and a volume of a synthetic additive solution. 1. A method for obtaining platelets in a combined storage medium comprising:a) separating platelets from a biological fluid that includes plasma and platelets;b) collecting a targeted number of platelets;c) concentrating said separated platelets;d) removing plasma from the concentrated platelets until the amount of residual plasma remaining with the concentrated platelets reaches a pre-determined volume;e) determining a volume of a combined storage medium effective for storing said targeted number of platelets; andf) combining said platelets in said pre-determined volume of residual plasma with an amount of a synthetic additive solution to arrive at said determined volume of said combined storage medium.2. The method of wherein said volume of residual plasma remaining with said concentrated platelets is approximately 10-50 ml.3. The method of wherein said residual volume of plasma remaining with said concentrated platelets is approximately 30 ml.4. The method of wherein said number of platelets is about 2.0×10to about 15.0×10.5. The method of wherein the volume of the combined storage medium is about 100-1 claim 1 ,200 ml.6. The method of wherein the volume of the combined storage medium is about 250-750 ml.7. The method of wherein the ratio of residual plasma to said synthetic additive solution is between about 1:99 and 50:50.8. The method of wherein the ratio of residual plasma to said additive solution is between about 35:65 and 5:95.9. The method of further comprising collecting said platelets and said combined storage medium in one or more collection containers.10. The method of comprising separating and concentrating said platelets in one or more chambers of a processing apparatus.11. The method of ...

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15-05-2014 дата публикации

BLOOD COMPONENTS SEPARATOR DISK

Номер: US20140131292A1
Принадлежит: HARVEST TECHNOLOGIES CORPORATION

A separator disk for use in centrifugal separation of components is designed to automatically position itself during separation at the interface between the supernatant and the remaining components. Preferably the interface is between plasma and red blood cells. 1. In combination , a tube adapted to contain a fluid to be subjected to centrifugation and a separator disk in said tube adapted to separate components of said fluid having different specific gravities , said disk being made of a material having a specific gravity near the specific gravity of the components at an interface.2. A combination according to wherein said disk fits into said tube such that a gap is formed between the perimeter of said disk and the interior of said tube claim 1 , said gap being of such a dimension that the component of said below said disk after separation will not flow through said gap at about 1G.3. A combination according to further comprising a shaft extending along said tube and engaging said disk such that said disk slides along said shaft.4. A combination according to wherein said disk is arranged to rotate about an axis transverse to the longitudinal axis of said tube to form a valve with the side of said tube during decanting.5. A combination according to further comprising a shaft extending along said tube and engaging said disk such that said disk slides along said shaft.6. A combination according to wherein said disk includes an upper outer edge and a lower outer edge and the transverse dimension between said upper outer edge and lower outer edge is greater than the internal diameter of said tube.7. A combination according to wherein the upper surface is curved.8. A combination according to wherein said upper surface is cylindrical.9. A combination according to wherein said disk is shaped such that its center of buoyancy is located above an upper surface of the disk.10. A combination according to wherein the specific gravity of said disk is such that its upper surface ...

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10-03-2022 дата публикации

CHAMBER FOR CENTRIFUGAL SEPARATION AND METHOD FOR CENTRIFUGAL SEPARATION USING THE SAME

Номер: US20220072563A1
Автор: HONG Min Pyo, SUNOO Joseph
Принадлежит: CYTODX INC.

A chamber for centrifugal separation includes a main body including a first opening and a second opening opposite to the first opening, a first cover coupled to the main body to close the first opening and including a first injection port to inject a material, a second cover coupled to the main body to close the second opening and including a second injection port to inject a material, and a filter device provided inside the main body and interposed between the first injection port and the second injection port, to prevent the material injected into the first injection port from being mixed with the material injected into the second injection port. 1. A chamber for centrifugal separation , comprising: 'a first cover coupled to the main body to close the first opening, and including a first injection port to inject a material;', 'a main body including a first opening and a second opening opposite to the first opening;'}a second cover coupled to the main body to close the second opening, and including a second injection port to inject a material; anda filter device provided inside the main body and interposed between the first injection port and the second injection port, to prevent the material injected into the first injection port from being mixed with the material injected into the second injection port.2. The chamber of claim 1 , wherein the filter device includes:a filter to filter a material; anda first filter supporting member to mount the filter on the first filter supporting member, a position of the first filter supporting member being fixed to an inner surface of the main body.3. The chamber of claim 2 , wherein the main body includes:a step part protruding inward from the inner surface of the main body, 'a second filter supporting member extending from the first filter supporting member in a direction from the first injection port toward the second injection port, and', 'wherein the filter device further includeswherein the position of the first filter ...

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10-03-2022 дата публикации

ROTOR FOR CENTRIFUGE AND CENTRIFUGE COMPRISING THE SAME

Номер: US20220072564A1
Принадлежит: CYTODX INC.

A rotor for a centrifuge includes a main body to rotate about a rotating axis extending in a vertical direction, a first chamber coupled to the main body to be rotatable about a first axis perpendicular to a direction parallel to the vertical direction, and having a first space to receive a material, and a second chamber coupled to the main body to be rotatable about a second axis parallel to the first axis and having a second space to receive a material. The first space and the second space have mutually different sizes, and the center of mass of the rotor is positioned on the rotating axis. 1. A rotor for a centrifuge , the rotor comprising:a main body configured to rotate about a rotating axis extending in a vertical direction;a first chamber coupled to the main body to be rotatable about a first axis perpendicular to a direction parallel to the vertical direction, and having a first space to receive a material; anda second chamber coupled to the main body to be rotatable about a second axis parallel to the first axis, and having a second space to receive a material,wherein the first space and the second space have mutually different sizes, and the center of mass of the rotor is positioned on the rotating axis.2. The rotor of claim 1 , wherein the main body includes:a first opening part that is open to place the first chamber;a second opening part that is open to place the second chamber;a pair of first protrusions formed to face each other while extending in the first axis from an inner surface of the first opening part; anda pair of second protrusions formed to face each other while extending in the second axis from an inner surface of the second opening part, andwherein the first chamber includes:a pair of first grooves to insert the pair of first protrusions, respectively; anda pair of second grooves to insert the pair of second protrusions, respectively.3. The rotor of claim 2 , wherein the first groove and the second groove are open in sides corresponding ...

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03-03-2016 дата публикации

System for Blood Separation with Replacement Fluid Apparatus and Method

Номер: US20160058938A1
Принадлежит: TERUMO BCT, INC.

A method is provided in a centrifugal blood processing system for adding replacement fluid without a dedicated peristaltic pump to blood components being returned to the donor. A disposable blood processing set for use in the method comprises a hermetically sealed set of blood bags, connecting tubes, needles or connectors, and supporting structures with a replacement fluid line coupled directly to a return reservoir without contact with an intervening pump. 1. A disposable blood processing set for use on a centrifugal blood processing device , said disposable set comprising:a blood separation chamber adapted to be mounted on a rotor of said centrifugal blood processing device;a blood inlet line adapted to be coupled to a blood donor and to an inlet pump on said centrifugal blood processing device;an anti-coagulant line in fluid communication with said inlet line, said anti-coagulant line being adapted to be fluidly coupled to a supply of anti-coagulant and being further adapted to be coupled to an anti-coagulant pump on said centrifugal blood processing device;a reservoir adapted to be coupled to at least one sensor for detecting a level of fluid in said reservoir;a return line in fluid communication with said reservoir, said return line being adapted to be coupled to said blood donor and to a return pump on said centrifugal blood processing device;a red blood cell line in fluid communication with said blood separation chamber and said reservoir;a collect line in fluid communication with said blood separation chamber and in selective communication with said reservoir and a collect bag, said collect line being adapted to be coupled to a collect pump;a plasma line in fluid communication with said blood separation chamber and with said reservoir, said plasma line being adapted to be coupled to a plasma pump; anda replacement fluid line in fluid communication with said reservoir and adapted to be placed in fluid communication with a source of replacement fluid.2. A ...

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21-02-2019 дата публикации

SYSTEMS AND METHODS FOR PARALLEL CHANNEL MICROFLUIDIC SEPARATION

Номер: US20190054229A1
Принадлежит:

The present disclosure describes a system and method for microfluidic separation. More particularly, the disclosure describes a system and method for the purification of a fluid by the removal of undesired particles. The device includes microfluidic separation channels that include multiple outlets. The device also includes isolation slots positioned between each of the microfluidic separation channels. The device's base includes multiple acoustic transducers which in some implementations are configured to protrude into the isolation slots. The acoustic transducers are configured to generate aggregation axes within the separation channels, which are used to separate out undesired particles. 1. A separation device comprising: a plurality of microfluidic separation channels each having an upstream portion and a downstream portion, the upstream portion comprising an inlet and the downstream portion comprising at least a first outlet and a second outlet; and', 'one or more isolation slots, one of the one or more isolation slots positioned between each of the plurality of microfluidic separation channels; and, 'a plastic substrate defininga base substrate coupled to the plastic substrate and comprising one or more acoustic transducers, each of the one or more acoustic transducers coupled to a wall of one or more of the respective plurality of microfluidic separation channels.2. The device of claim 1 , wherein each of the one or more acoustic transducers protrude perpendicular to a face of the base substrate and into a respective one of the one or more isolation slots.3. The device of claim 1 , wherein the first outlet of each of the plurality of microfluidic separation channels is positioned substantially along a longitudinal axis of the respective microfluidic separation channel.4. The device of claim 1 , wherein the second outlet of each of the plurality of microfluidic separation channels is positioned adjacent to a wall of the respective microfluidic separation ...

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04-03-2021 дата публикации

METHOD AND APPARATUS FOR CONTINUOUS REMOVAL OF SUB-MICRON SIZED PARTICLES IN A CLOSED LOOP LIQUID FLOW SYSTEM

Номер: US20210060579A1
Принадлежит:

A centrifuge rotor having a curved shape is offset on a spinning rotor base and creates contiguous areas of low to high centrifugal force depending on the distances from the axis of the rotor base and a method of separating components in a fluid based upon a difference in density of the components, the method comprising the steps of providing to a rotor as described herein the fluid containing the mixed together components to be separated based upon the difference in density of the mixed together components; continuously flowing the components in the fluid to the rotor through an input tube connected to the input port while the rotor is spinning about a centrifugal axis of rotation; separating the components in the fluid into fractions based upon the difference in density of the mixed together components with the use of centrifugal force when the rotor is spinning; collecting components having i) a first density via a first tube connected to the output port at the first end on the rotor, ii) a second density via a second tube connected to the output port at the second end on the rotor, iii) a third density via a third tube connected to the output port at the junction on the rotor and iv) a fourth density via a fourth tube connected to the output port between the input port and the output port at the first end. 1. A rotor comprising:a hollow curved housing that has an inner wall and an outer wall, a top, a bottom and a first end and a second end wherein the inner wall is radially closer to an axis of rotation as compared to the outer wall;the hollow curved housing being formed of a curved first rotor element that terminates at the first end of the curved housing and a curved second rotor element that terminates at the second end of the curved housing wherein the curved housing between the curved first rotor element and the curved second rotor element includes a junction that creates a change in an inner and outer radius of the first rotor element as compared to an ...

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04-03-2021 дата публикации

Separation Of Fluids

Номер: US20210060580A1
Принадлежит:

A centrifuge has a mechanical drive coupled to a capsule rotatable simultaneously about mutually orthogonal X, Y, and Z axes. A stationary base has a first motor driving a centrally located hub in rotation about the Z axis. The hub has a pair of colinear arms and a pair of struts extending from the arms to support an outer ring. An inner ring is positioned concentric with the outer ring and a second motor is engaged with both the outer ring and inner ring so that it is enabled for rotating the inner ring relative to the outer ring. A third motor is engaged with both the inner ring and the capsule for rotating said capsule relative to the inner ring. The simultaneous rotation of the capsule about all three axes is therefore possible. 1. A centrifuge positioned in a three-axis coordinate system , said centrifuge comprising:a mechanical drive;a capsule engaged with said mechanical drive wherein said capsule is engaged with said mechanical drive to rotate about mutually orthogonal X, Y, and Z axes of said coordinate system;a stationary base having a first motor of the mechanical drive, wherein said first motor operates a centrally located hub in rotation about said Z axis and the hub has a pair of colinear arms oriented in parallel with an X-Y plane of the coordinate system; anda pair of struts extending from the colinear arms, the struts supporting a second motor of the mechanical drive, wherein the second motor is engaged with an inner ring and enabled for rotating said inner ring relative to said struts about said X axis.2. (canceled)3. (canceled)4. The centrifuge of further comprising a pair of struts extending from said colinear arms claim 1 , said struts supporting an outer ring.5. The centrifuge of further comprising an inner ring positional concentric with said outer ring.6. The centrifuge of further comprising a second motor of said mechanical drive claim 5 , wherein said second motor is engaged with both said outer ring and said inner ring and enabled for ...

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20-02-2020 дата публикации

Fixed Angle Rotor

Номер: US20200055060A1
Автор: KUHNERT Steffen
Принадлежит:

A fixed-angle rotor for centrifuges includes stiffening ribs on the lower side of its rotor body. Its rotational energy is comparatively low during operation even at high speeds, whereby safety is noticeably increased without the need for a reinforced armored vessel in the centrifuge that is equipped therewith. At the same time, the drive power required to drive the fixed-angle rotor remains low. The fixed-angle rotor also withstands extreme loads over a long period of time. In addition, the fixed-angle rotor can be manufactured cost-effectively, because no additional components are required; rather, the stiffening ribs can also be manufactured during the manufacture of the rotor body. Finally, very thin rotor shells can also be used, which improves the temperature control of the samples, because the fixed-angle rotor has very good structural stability, especially in the main load directions. 1. A fixed-angle rotor for a centrifuge , comprising: an upper side and an oppositely arranged lower side and', 'a hub which is arranged around a rotor axis;, 'a rotor body having'}at least two holders for samples to be centrifuged arranged in the rotor body around the rotor axis, wherein the holders have openings on the upper side for introducing samples; andat least one stiffening rib formed on the lower side of the rotor body.2. The fixed-angle rotor according to claim 1 ,wherein at least one of the at least one stiffening ribs runs in a radial manner in relation to the rotor axis.3. The fixed-angle rotor according to claim 1 ,wherein at least one of the at least one stiffening ribs runs in direction of the holder.4. The fixed-angle rotor according to claim 1 ,wherein at least one of the at least one stiffening ribs runs in direction of a central axis of the holder.5. The fixed-angle rotor according to claim 1 ,wherein at least one of the at least one stiffening ribs runs between one of the at least two holders and the hub.6. The fixed-angle rotor according to claim 5 , ...

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05-03-2015 дата публикации

Method and Apparatus for Producing Platelet Rich Plasma

Номер: US20150064687A1
Автор: Nemirovsky Alexander
Принадлежит:

A device and method for producing a portion of platelet rich plasma from a fluid sample obtained from a patient. The device comprises three intercommunicated portions, each portion having an internal chamber defined therein. The fluid sample is first brought into the base portion where it is separated into red blood cells and plasma. The plasma portion of the sample is then withdrawn into the second portion where it is further separated into platelet poor plasma disposed over platelet rich plasma. The portion of platelet poor plasma is then withdrawn from the second chamber, leaving only platelet rich plasma within the second chamber. The base portion also includes a membrane located on its distal end which helps maintain a vacuum within the device when the fluid sample is being initially inserted into base chamber. 1. A device for producing platelet rich plasma (PRP) comprising:a base portion comprising a base chamber defined therein;a second portion coupled to the base portion, the second portion comprising a middle chamber defined therein; anda third portion coupled to the second portion, the third portion comprising a top chamber defined therein,wherein the middle chamber is fluidly communicated to the base chamber, andwherein the top chamber is fluidly communicated to the middle chamber.2. The device of where the second portion and the third portion are removably coupled from the base portion and the second portion claim 1 , respectively.3. The device of further comprising:a base plunger disposed within the base chamber;a nozzle disposed on the second portion configured to removably couple to the base plunger;a middle plunger disposed within the middle chamber; anda secondary nozzle disposed on the third portion configured to removably couple to the middle plunger.4. The device of where the base portion further comprises an aperture disposed on its distal end configured to accommodate a needle or fluid line.5. The device of where a distal end of the base ...

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28-02-2019 дата публикации

SWING-OUT CENTRIFUGE

Номер: US20190060915A1
Автор: Liang Wenhua
Принадлежит:

A centrifuge has a hollow shell and a rotor supported by the shell. A motor is coupled to the rotor to rotate the rotor relative to the shell. Plural receptacles are formed in the rotor and respective tube holders are pivotably mounted in respective receptacles in a vertical orientation. The tube holders hold one or more test tubes containing material to be centrifuged, and the tube holders pivot within their receptacles to a horizontal orientation under the influence of spinning the rotor. The rotor can be formed with a top surface into which the receptacles are established, with the tube holders (and test tubes) being substantially completely below the top surface in the horizontal orientation to reduce friction with the air while spinning. 1. An apparatus , comprising:at least one hollow rotatable member formed with plural receptacles;plural tube holders pivotably coupled to respective ones of the receptacles, at least some tube holders being formed with at least one tube cavity into which a respective tube holding material can be disposed, the tube holders assuming a vertical orientation when the rotatable member does not rotate with respective tops of the tube holders being vertically above respective bottoms of the tube holders; andat least one motor coupled to the rotatable member to rotate the rotatable member to thereby cause the tube holders to pivot in their respective receptacles to a horizontal orientation, in which the respective tops of the tube holders are radially inward of the respective bottoms of the tube holders and the tube holders are disposed within an interior of the rotatable member to shelter the tube holders from wind resistance as the rotatable member rotates.2. The apparatus of claim 1 , comprising the respective tubes.3. The apparatus of claim 1 , wherein the rotatable member is formed with a top surface into which the receptacles are established claim 1 , the tube holders being substantially completely below the top surface in the ...

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28-02-2019 дата публикации

MASS-TRANSFER APPARATUS

Номер: US20190060916A1
Принадлежит:

An apparatus for mass transfer between a liquid and a gas inside a rotor having a packing. The liquid is introduced at a center of the rotor and driven outward through the packing by centrifugal force generated by rotation of the rotor, and the gas surrounding the rotor is forced inward through the rotor by a pressure of the gas, counter to the liquid flow in the rotor. The packing inside the rotor is divided into individual packing segments that together form a circular disk. Each circular ring segment is formed by at least one structured packing comprised of a plurality of superimposed woven, knitted, mesh or lattice structured surfaces composed of metal, in particular sheet-metal strips, or plastic or glass fibers, to which the axis of rotation of the rotor runs perpendicular. 2. The apparatus defined in claim 1 , wherein the structured surfaces are undulating with the undulations of each structured surface lying parallel to one another.3. The apparatus defined in claim 2 , wherein the undulations of the structured surface are of zigzag-shaped cross section.4. The apparatus defined in claim 2 , wherein the undulations of one structured surface extend at an angle to the undulations of an adjacent structured surface claim 2 , so that intersecting flow passages exist between two structured surfaces.5. The apparatus defined in claim 1 , wherein the structured surfaces are composed of metal and/or plastic wires or sheet-metal strips or glass fibers.6. The apparatus defined in claim 5 , wherein the metal and/or plastic wires have a diameter of 0.1 to 0.5.7. The apparatus defined in claim 1 , wherein the structured packing in the rotor is assembled from 2 to 64 packing segments.8. The apparatus defined in claim 1 , the inner ends of the packing segments form an inner cylindrical claim 1 , coaxial annular space from which the flow passages proceed and into which the liquid is supplied.9. The apparatus defined in claim 1 , wherein outer ends of the packing segments form ...

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