01-08-2013 дата публикации
Номер: US20130193598A1
The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T, wherein Tis greater than T. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter. 1. A spray-drying process , comprising:{'sub': 1', '2', '2', '1, '(a) delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, wherein said spray solution is initially at a temperature T, and wherein said delivering further comprises directing said spray solution to a heat exchanger to increase the temperature of the spray solution to a temperature T, wherein temperature Tis greater than temperature T;'}{'sub': 3', '3', '2, '(b) atomizing said spray solution into droplets within said spray-drying apparatus via a flash nozzle to remove at least a portion of said solvent from said droplets to form a plurality of particles, wherein said flash nozzle comprises a central tube and an outer tube, and wherein said spray solution is delivered through said central tube at a temperature T, wherein temperature Tis less than or equal to temperature T, and a sweep gas is delivered through said outer tube; and'}(c) collecting said particles, wherein said particles comprise said at least one solute.2. The process of claim 1 , wherein said central tube has a first outer diameter and a first inner diameter at an inlet claim 1 ...
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