Method of preparing alkanolamines or their salts in form of racemate or optically active antipodes

The method of obtaining aminopropanol, their salts or optically active antipodes

Method of producing 1-isopropylamino-3-/4-(2-methoxyethyl)-phenoxy/-2-propanol

A process for the preparation of metoprolol or 1isopropylamino-3-(4-(2-methoxy)ethylphenoxy)-2-propanol wherein 3-(4-(2-methoxy)ethyl)phenoxy-1,2-propanediol is reacted with thionyl chloride in dichlormethane in the presence of triethylamine to form 4-(4-((2-methoxy-ethyl)phenoxy)methyl)-1,3,2-dioxathiolane-2-oxide < IMG > which is then reacted with isopropylamine in acetonitrile.

Method of obtaining aminopropanol derivatives or salts thereof

Patent FR2261000A1

Method of preparing propanolamine derivatives or salts thereof

Novel polyamines and a process for their preparation

Disclosed is a polyamine of the formula I: , (wherein n is 1, 2 or 3; R is a linear or branched alkylene, cycloalkylene, (cyclo)alkylene or (phenylene)alkylene radical (1) which has 2 to 22 carbon atoms, (2) which may contain one to four C1-3 alkyl groups, (3) which may have one to three NH groups in place of CH2 groups and (4) which may have one oxygen atom in place of a CH2 group; and R1 is an alkyl, cycloalkyl, aryl or alkylaryl radical having 4 to 24 carbon atoms when n is 1, or a linear or branched saturated aliphatic hydrocarbon, saturated (cyclo)aliphatic hydrocarbon or saturated aliphatic-aromatic hydrocarbon radical having 4 to 24 carbon atoms when n is 2 or 3, each of which may have one to four CH3 groups and wherein one or more CH2 groups may be replaced with oxygen). The polyamine is useful as a cross-linking (e. g. curing) agent of epoxy resins and is environmentally safe due to its low vapor pressure.

Patent FR2179069B1

Method of producing aryloxyaminobutanol or salts thereof

Novel aryloxyaminobutanols of the general formula (I) <IMAGE> in which R represents an optionally substituted aryl group and R<1> represents an alkyl, cycloalkyl or aralkyl group, it being possible for the aryl group to be substituted, and also the stereoisomers and the non-toxic acid addition salts of these compounds, are beta-receptor blockers and have antiarrhythmic action. The compounds are prepared by reacting compounds of the general formula (III) <IMAGE> and compounds of the general formula (IV> X-R<1> (IV> in which X represents a leaving group, or reacting compounds of the general formula (III) with compounds of the general formula (V) <IMAGE> and simultaneously or subsequently reducing, and if desired reacting the resulting compounds of the general formula (I) to give their non-toxic acid addition salts or liberating them from their salts. The stereoisomers of the formula III can be used as starting materials.

Enantioselective process for the preparation of leveobunolol

The invention relates to a new, industrially advantageous, process for the preparation of the known beta-adrenergic blocking agent, levobunolol, not requiring resolution of racemic bunolol, based on the enantioselective synthesis of an oxiranic intermediate which is then reacted with tert-butylamine. It consists of reacting 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone with (R)-(-)epichlorhydrine in an aprotic solvent, in the presence of a strong base at a temperature of over 90 DEG C., thus obtaining the intermediate chiral oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1-(2H)-naphthalenone with more than 95% optical purity, and then, the intermediate chiral oxirane is reacted with tert-butylamine.

PROCESS FOR PREPARING 2 (2'-HYDROXY-3 '- (1,1-DIMETHYLPROPYLAMINO) -PROPOXY) -BETA-PHENYLPROPHENOPHENONE

LIQUID CATALYSTS FOR THE QUICK POLYMERIZATION OF LIQUID COMPOSITIONS BASED ON POLYISOCYANATES AND EPOXY.

Method for the preparation of metoprolol

Abstract A process for the preparation of metoprolol or 1-isopropylamino-3-(4-(2-methoxy)ethylphenoxy)-2-propanol wherein 3-(4-(2-methoxy)ethyl)phenoxy-1,2-propanediol is reacted with thionyl chloride in dichlormethane in the presence of triethylamine to form 4-(4-((2-methoxy-ethyl)phenoxy)methyl)-1,3,2-dioxathiolane-2-oxide

O-HYDROXY-SS- (1-NAPHTHYL) -PROPIOPHENONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICAMENT CONTAINING THESE COMPOUNDS

o-Hydroxy- beta -(1-naphthyl)-propiophenone derivatives of general formula (I) and their acid addition salts, process for producing them and drugs containing these compounds.

Novel process for the preparation of substantially pure 5-(3,5-dimethylphenoxy)methyl-2-oxazolidinone

Patent FR2261000B1

Method of production of 2-[2ъ-hydroxy-3ъ-(1.1-dimethyl-propylamine)-propoxy]-beta-phenylpropiophenone or its pharmaceutically acceptable salts

PROCESS FOR PREPARING 2- / 2'-HYDROXY-3 '- (1,1-DIMETHYLPROPYLAMINO) PROPOXY / BETA PHENYLPROPIOPHENONE

Die Erfindung betrifft ein Verfahren zur Herstellung von 2-(2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy)-Beta-phenylpropiophenon der Formel I und seinen Saeureadditionssalzen. Die Verbindung und ihre Saeureadditionssalze haben eine antiarrhytmische Wirkung. Sie koennen daher zur Behandlung von Herzrhythmusstoerungen verwendet werden.

PROCEDURE FOR PRODUCING A NEW HEART ACTIVE ASSOCIATION

2-(2'-hydroxy-3'-(1,1,-dimethyl propylamino)-propoxy)-beta propiophenone, its addition salts, process for its preparation and medicaments

The 2-[2'-hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]- beta -phenylpropiophenone of formula I <IMAGE> (I) <IMAGE> and its acid addition salts are described. Moreover, the preparation of this compound and of its acid addition salts is described. The compound and its acid addition salts have an antiarrhthymic effect. They can therefore be used for treating heart rhythm disorders.

2-[2'-HYDROXY-3'-(1,1-DIMETHYLPROPYLAMINO)- PROPOXY]-.beta.-PHENYLPROPIOPHENONE, ITS ACID ADDITION SALTS, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS

A B S T R A C T The 2-[2'-hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]-.beta.-phenylpropiophenone of formula I

Polyols useful for preparing polyurethane foams having improved retention of insulative properties, polyurethane foams prepared therewith and methods for the preparation thereof

用两种新的多羟基化合物的一种或多种可制备 提高了绝热性能保持时间的聚氨酯泡沫。一种多羟 基化合物为式(Ⅰ)的聚醚，其中Q具有通式(Ⅱ)，它 通过环氧乙烷与通式(Ⅲ)化合物反应来制备，其中基 团定义见说明书。另一种多羟基化合物通过(1)碳酸 亚乙酯与一种或多种羟基官能化合物反应形成多羟 基化合物前体，和(2)该前体与二乙二醇及酸酐、二元 羧酸、三元羧酸或其混合物任选在催化剂存在下反应 而制得。

1,4-methano- and 1,4-ethano-tetrahydronaphthyloxypropanols, processes for their preparation and pharmaceuticals containing them

A method of producing amines

Alkanolamine derivatives

Novel aryloxyaminobutanols of the general formula (I) < IMAGE > in which R represents an optionally substituted aryl group and R<1> represents an alkyl, cycloalkyl or aralkyl group, it being possible for the aryl group to be substituted, and also the stereoisomers and the non-toxic acid addition salts of these compounds, are beta-receptor blockers and have antiarrhythmic action. The compounds are prepared by reacting compounds of the general formula (III) < IMAGE > and compounds of the general formula (IV> X-R<1> (IV> in which X represents a leaving group, or reacting compounds of the general formula (III) with compounds of the general formula (V) < IMAGE > and simultaneously or subsequently reducing, and if desired reacting the resulting compounds of the general formula (I) to give their non-toxic acid addition salts or liberating them from their salts. The stereoisomers of the formula III can be used as starting materials.

Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases

Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula < IMAGE > and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R1 is alkyl or hydroxy alkyl, R2 is alkoxyalkyl, alkylthioalkyl, alkoxycarbonylaminoalkyl, or alkoxyalkoxy, and R3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed as are methods for their preparations Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the beta -receptors of the heart making them useful in treating heart diseases in animals including humans.

ANALOGIFICANT FARING FOR FRAMSTAELLNING AV SOM CEILING MODEL ANVAENDBAR 2- / 2'-HYDROXI-3 '- (1,1-DIMETHYLPROPYLAMINO) - PROPOXI / -BETA-PHENYLPROPIOFENONE OCH SYREADDITIONSSALTER AV

Use of propanolamine derivatives as selective 5-HT1 antagonists

This invention provides a method of selectively antagonizing-the 5-HT 1A receptor in mammals by administering aryloxypropanolamines. Aryloxypropanolamines are also claimed.

ANALOGIFICATION OF FRAMSTAELLNING AV SOM LAEKEMEDEL ANVAENDBAR 2- / 2'-HYDROXI-3 '- (1,1-DIMETHYLPROPYLAMINO) -PROPOX / -PHENYLPROPIOFENONE OCH SYREADDITIONSSALTER AV DENNA

Polyols useful for preparing polyurethane foams having improved retention of insulative properties, polyurethane foams prepared therewith and methods for the preparation thereof

Polyurethane foams having improved retention of insulative properties can be prepared using one or more of two novel polyols. One of the polyols is a polyether having general formula (I), wherein T is any group substantially unreactive with epichlorohydrin except a halogen, Z is an integer from 0 to 8 and Q has general formula (II), wherein A is N, S or O; L is a covalent bond or a connecting group having from 1 to 10 carbons; I is an integer from 1 to 10; J is an integer from 2 to 8; and D is H, L-(((CH2CH2O)I)H)J, an alkyl or an aromatic group if A is N or an electron pair if A is S or O, prepared by reacting a monoepoxide with a compound having general formula (III), wherein X is H, Li, Na, K; A is N, S or O; L is a covalent bond or a connecting group having from 1 to 10 carbons; M is any group capable of reacting with an ethylene oxide molecule in the presence of a basic catalyst; and J is an integer from 2 to 8. The other polyol is prepared by (1) admixing ethylene carbonate and one or more hydroxyl functional compounds under reaction conditions sufficient to react the ethylene carbonate and the hydroxyl functional compounds to produce a polyol precursor, and (2) admixing the polyol precursor with diethylene glycol and an anhydride, a dicarboxylic acid, a tricarboxylic acid or mixtures thereof, optionally in the presence of a catalyst.

o, p-Disubstituted 3-phenoxy-lalkylamino-propan-2-ols, processes for their preparation and pharmaceuticals containing them

1,4-methano and ethano-tetrahydro-naphthloxypropanols and process for their preparation

AMINE DERIVATIVES, PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM

RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol, process for preparation thereof and process for preparation of RS betaxolol

The present invention relates to RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol of the formula (1), process for preparation thereof by selective allylation of p-hydroxy phenyl ethanol and use thereof in a preparation of RS betaxolol of formula (2)

Patent JPS6240352B2

The 2-[2'-hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]- beta -phenylpropiophenone of formula I <IMAGE> (I) <IMAGE> and its acid addition salts are described. Moreover, the preparation of this compound and of its acid addition salts is described. The compound and its acid addition salts have an antiarrhthymic effect. They can therefore be used for treating heart rhythm disorders.

Patent FR2261001B1

Polyol for preparing polyurethane foam process for preparing polyol; polyester polyol, process for preparation thereof; polyurethane foam, process for preparation thereof, polyurethane composition

Пенополиуретаны с улучшенной способностью сохранять изоляционные свойства могут быть получены с использованием одного или более новых полиолов. Одним из полиолов является полиэфир, имеющий общую формулу Iв которой T - любая группа, фактически нереакционноспособная по отношению к эпихлоргидрину, за исключением галогена, Z - любое число от 0 до 8, Q имеет общую формулу IIв которой A - N, S или O; L - ковалентная связь или соединительная группа, имеющая от 1 до 10 атомов углерода; I целое число от 1 до 10; J - целое число от 2 до 8; D - H, L - (((CHCHO))H), алкил или ароматическая группа, если A - N, или электронная пара, если A - S или O,полученный реакцией моноэпоксида с соединением, имеющим общую формулу IIIв которой X - H, Li, Na, K; A - N, S или O; L - ковалентная связь или соединительная группа, имеющая от 1 до 10 углеродных атомов, M - любая группа, способная реагировать с этиленоксидной молекулой в присутствии основного катализатора; J - целое число от 2 до 8. Другой полиол получается при смешении этиленкарбоната и одного или более соединений с гидроксильной функциональностью в реакционных условиях, достаточных для реакции этиленкарбоната с соединениями с гидроксильной функциональностью с получением полиольного предшественника, и смешением полиольного предшественника с диэтиленгликолем и ангидридом, дикарбоновой кислотой, трикарбоновой кислотой или их смесями, необязательно, в присутствии катализатора.

Hydroxypropafenonglyceride.

Nytt foerfarande foer framstaellning av 1-isopropylamin-3-(p-(2-metoxyetyl)-fenoxy)-2-propanol

Forfarande for framstellning av 1-isopropylamin-3-/p-(2-metoxietyl)-fenoxi/-2-propanol

一种香草酸基双子表面活性剂及其制备方法和应用

本申请公开了一种香草酸基双子表面活性剂及其制备方法和应用，所述香草酸基双子表面活性剂的结构通式如式I所示：

一种香草酸基双子表面活性剂及其制备方法和应用

本申请公开了一种香草酸基双子表面活性剂及其制备方法和应用，所述香草酸基双子表面活性剂的结构通式如式I所示：

Mellomprodukt ved fremstilling av 1-isopropylamin-3-(p-(2-metoksyetyl)fenoksy)-2-propanol

Mellomprodukt ved fremstilling av 1-isopropylamin-3-[p-(2-metoksyetyl)fenoksy]-2-propanol.

Mellomprodukt ved fremstilling av 1-isopropylamin-3-(p-(2-metoksyetyl)fenoksy)-2-propanol

Forfarande for framstellning av 1-isopropylamin-3-(p-(2-metoxietyl)fenoxi)-2-propanol

Mellanprodukt vid framstellning av 1-isopropylamin-3-(p-(2-metoxietyl)fenoxi)-2-propanol

Process for preparing 11isopropylaminoo33*pp*22methoxyethyl* phenoxy**22propanol

Forfarande for framstellning av 1-isopropylamin-3-(p-(2-metoxietyl)fenoxi)-2-propanol

Mellomprodukt ved fremstilling av 1-isopropylamin-3-(p-2(2-metoksyetyl)fenoksy)-2-propanol

Sposob wytwarzania 1-izopropyloamino-3-/p-(2-metoksyetylo)fenoksy/propanolu-2

Mellomprodukt ved fremstilling av 1-isopropylamin-3-(p-(2-metoksyetyl)fenoksy)-2-propanol

Ny fremgangsmaate for fremstilling av 1-isopropylamin-3-(p-(2-metoksyetyl)fenoksy)-2-propanol

Mellanprodukt vid framstellning av 1-isopropylamin-3-(p-(2-metoxietyl)fenoxi)-2-propanol

Forfarande for framstellning av 1-isopropylamin-3-(p-(2-metoxietyl)fenoxi)-2-propanol

Fremgangsmaate for fremstilling av 1-isopropylamin-3-(p-(2-metoksyetyl)fenoksy)-2-propanol

Mellanprodukt vid framstaellning av 1-isopropylamin-3-/p-(2-metoxietyl)fenoxi/-2-propanol

Mellanprodukt vid framstaellning av 1-isopropylamin-3-/p-(2-metoxietyl)-fenoxi/-2-propanol

Mellomprodukt ved fremstilling av 1-isopropylamin-3-(p-(2-metoksyetyl)fenoksy)-2-propanol

Mellomprodukt ved fremstilling av 1-isopropylamin-3-(p-2(2-metoksyetyl)fenoksy)-2-propanol

Fremgangsmaate for fremstilling av 1-isopropylamin-3-(p-(2-metoksyetyl)fenoksy)-2-propanol

Fremgangsmaade til fremstilling af 1-isopropylamin-3-(p-(2-metoxyetyl)fenoxy)-2-propanol

Method of producing 1-isopropyloamino-3-/p-/2-methoxyethylo/phenoxy/-propanol-2

Nytt foerfarande foer framstaellning av 1-isopropylamin -3-(p-(2-metoxyetyl)fenoxy)-2-propanol

Nytt foerfarande foer framstaellning av 1-isopropylamin-3-(p-(2-metoxyetyl)fenoxy)-2-propanol

Verfahren zur herstellung des 1-(2-allyloxyphenoxy)-3-isopropylamino-2-propanols und seiner salze

Fluoriertes propranolol und ahnliche verfahren

바이오매스 물질인 카다놀 기반 폴리올 합성 방법과 이 방법에 의해 합성된 폴리올 및 이를 이용한 비촉매 폴리우레탄 폼 조성물

본 발명은 바이오매스 물질인 카다놀 기반 폴리올 합성 방법과 이 방법에 의해 합성된 폴리올 및 이를 이용한 비촉매 폴리우레탄 폼 조성물에 관한 것으로, 친환경 소재인 카다놀 기반 폴리올을 이용하여 촉매를 사용하지 아니하고, 발포제로서 물을 사용함으로써, 인체에 유해한 휘발성 유기화합물(VOCs), 포름알데히드와 같은 화합물을 배출하지 않으므로 친환경적 공법에 의해 제조된 경질에서부터 연질의 물성을 갖는 폴리우레탄 폼을 제공하는 효과가 있다.

Procedimiento para la obtencion de 1-(2-aliloxifenoxi)-3- isopropilamino-2-propanol

Manufacture of unsaturated ether

Verfahren zur herstellung des 1-(2-allyloxyphenoxy)-3-isopropylamino-2-propanols und seiner salze

Propanolol fluorado e metodos associados

Propanolol fluorado y metodos asociados.

LA INVENCION SE REFIERE A BLOQUEANTES BETA FLUORADOS, COMO PROPANOLOL, CON EFECTOS ANTIOXIDANTES AMPLIFICADOS Y VARIOS NIVELES DE EFECTOS BETA BLOQUEANTES. SE PRESENTAN ASIMISMO MEZCLAS DE MEDICAMENTOS ANTIOXIDANTES FLUORADOS, COMO PROPANOLOL, CON ANALOGOS BLOQUEANTES NO BETA, ANTIOXIDANTES, FLUORADOS DE DICHOS MEDICAMENTOS. SE DESCRIBEN TAMBIEN METODOS DE TRATAMIENTO DE ENFERMEDADES MEDIANTE LA UTILIZACION DE DICHOS MEDICAMENTOS FLUORADOS Y DICHAS MEZCLAS.

Fluoriertes propranolol und ahnliche verfahren

フッ素化されたプロプラノロール及びそれに関連する方法

(57)【要約】 増強された抗酸化作用と種々のレベルのベータブロッキング作用を持ったプロプラノロールのようなフッ素化ベータブロッカーを提供する。プロプラノロールのようなフッ素化抗酸化剤と同じ薬効成分のフッ素化抗酸化性の非ベータブロッキング類似体の混合物も提供する。フッ素化薬剤及びその混合物を使用した疾患の治療方法も提供する。

Fluorinated propranolol and related methods

Fluorinated beta blockers, such as propranolol, are presented with amplified antioxidant effects and various levels of beta blocking effects. Mixtures are also presented of fluorinated antioxidant drugs, such as propranolol, with flurinated antioxidant non-beta blocking analogs of the same drugs. Methods of treatement of disease by the use of the fluorinated drugs and the mixtures are presented.

Fluoriertes propranolol und ahnliche verfahren

Isopropyl amine compounds,processes for preparing them and compositions

RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol, process for preparation thereof and process for preparation of RS betaxolol

The present invention relates to RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol of the formula (1), process for preparation thereof by selective allylation of p-hydroxy phenyl ethanol and use thereof in a preparation of RS betaxolol of formula (2)

Guaiacoxypropanolamine derivatives with alpha/beta-adrenergic blocking activity

一种光引发剂及其制备方法

本发明涉及光引发剂技术领域，具体为一种光引发剂及其制备方法，其结构式如下式1所示： 其中，R1和R2相同或不同，各自独立的选自氢、氘、羟基、C1‑C4烃基或式2所示基团； R3和R4相同或不同，各自独立的选自氢、C1‑C4烃基、C6‑C30芳香基、C6‑C30芳香胺基，本发明的光引发剂光引发活性远大于二苯甲酮，而且无需加入叔胺类共引发剂，是一种高效的光引发剂。

Polyurethane coating

Isopropylamine compounds*their manufacture and medicine containing them

一种光引发剂及其制备方法

本发明涉及光引发剂技术领域，具体为一种光引发剂及其制备方法，其结构式如下式1所示： 其中，R1和R2相同或不同，各自独立的选自氢、氘、羟基、C1‑C4烃基或式2所示基团； R3和R4相同或不同，各自独立的选自氢、C1‑C4烃基、C6‑C30芳香基、C6‑C30芳香胺基，本发明的光引发剂光引发活性远大于二苯甲酮，而且无需加入叔胺类共引发剂，是一种高效的光引发剂。

普萘洛尔衍生物及其在抑制植物病原菌中的应用

本发明属于新药领域，具体涉及普萘洛尔衍生物及其在抑制植物病原菌中的应用。本发明提供的普萘洛尔衍生物在菌丝生长实验中发现，普萘洛尔可以抑制12种植物病原菌的菌丝生长，而其衍生物II‑8可以提高抑菌能力高达16倍，该衍生物是具有很高抑菌能力的新化合物。

一种香草酸基双子表面活性剂及其制备方法和应用

本申请公开了一种香草酸基双子表面活性剂及其制备方法和应用，所述香草酸基双子表面活性剂的结构通式如式I所示：