25-04-2013 дата публикации
Номер: US20130102681A1
Принадлежит:
Mito Tek, LLC
The present invention is directed to methods of modulating the activity of an isoform of manganese superoxide dismutase which is useful for the treatment of diseases such as heart failure. 153-. (canceled)54. A method of treating a mitochondrial related disease or condition in an individual comprising administering to the individual a therapeutically effective amount of an isoMnSOD inhibitor.55. The method of wherein said inhibitor comprises a compound of Formula I:{'br': None, 'sup': 1', '2, 'Alk-L-L-D\u2003\u2003I'} [{'sub': 2-100', '2-100, 'sup': '1', 'Alk is Calkenyl or Calkynyl, each optionally substituted by one or more R;'}, {'sup': 1', '2', '2', '2', '2', '2', '3', '2', '3, 'sub': 2', '2, 'Lis O, S, CO, C(O)O, C(O)NR, SO, S(O), S(O)NR, S(O)NR, NR, NRC(O)NR, or NRC(S)NR;'}, {'sup': 2', '4, 'sub': 1-6', '2-6', '2-6, 'Lis absent, Calkylenyl, Calkenylenyl, or Calkynylenyl, each optionally substituted by one or more R;'}, {'sup': '5', 'D is aryl or heteroaryl, each optionally substituted by one or more R;'}, {'sup': 1', '4', '6', '6', '6', '7', '7', '7', '8', '9', '8', '6, 'sub': 1-6', '1-6', '2-6', '2-6', '3-7', '2, 'Rand Rare each, independently, halo, cyano, nitro, Calkyl, Chaloalkyl, Calkenyl, Calkynyl, aryl, heteroaryl, Ccycloalkyl, heterocycloalkyl, S(O)R, S(O)R, C(O)R, OR, SR, C(O)OR, NRRor NRC(O)R;'}, {'sup': 2', '3, 'sub': 1-6', '2-6', '2-6', '1-6', '3-7', '3-7, 'Rand Rare each, independently, H, Calkyl, Calkenyl, Calkynyl, Chaloalkyl, aryl, heteroaryl, Ccycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl; (Ccycloalkyl)alkyl or heterocycloalkylalkyl;'}, {'sup': 5', '12', '12', '13', '14', '15', '12', '13', '14', '15', '14', '15', '14', '15', '14', '12', '13', '14', '15', '13', '14', '15, 'sub': 1-6', '2-6', '2-6', '1-4', '2', '2', '2, 'Ris halo, Calkyl, Calkenyl, Calkynyl, Chaloalkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, CN, NO, OR, SR, C(O)R, C(O)NRR, C(O)OR, OC(O)R, OC(O)NRR, NRR, NRC(O)R, NRC(O)OR, S(O)R, S(O)NRR, S(O)R, or S(O)NRR;'}, ...
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