СОЕДИНЕНИЯ, СПОСОБ ПОЛУЧЕНИЯ СОЕДИНЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ

Описывается соединение формулы (I) в свободной форме или в форме соли, где Ar обозначает группу формулы R1 обозначает водород или гидрокси, R2 и R3 каждый независимо друг от друга обозначает водород или С1-С4алкил, R4, R5, R6 и R7 каждый независимо друг от друга обозначает водород, С1-С4алкокси, C1-С4алкил или С1-С4алкил, замещенный С1-С4алкоксигруппой, или R5 и R6 вместе с атомами углерода, к которым они присоединены, обозначают 6-членное циклоалифатическое кольцо или 6-членное гетероциклическое кольцо, содержащее два атома кислорода, R8 обозначает -NHR13, где R13 обозначает водород, С1-С4алкил или -COR14, где R14обозначает водород, или R13 обозначает –SO2R17, где R17 обозначает С1-С4алкил, и R9 обозначает водород, или R8 обозначает -NHR18, где -NHR18 и R9 вместе с атомами углерода, к которым они присоединены, обозначают 6-членный гетероцикл, R10 обозначает -ОН, Х обозначает С1-С4алкил, Y обозначает углерод, n равно 1 или 2, p равно 1, q означает 1, r означает 0 или 1. Описывается также ...

СПОСОБ ПОЛУЧЕНИЯ ФОРМАМИДА

Изобретение относится к области химической технологии, точнее к способам получения незамещенных амидов карбоновых кислот, в частности к способу получения формамида. Предложен способ получения формамида путем взаимодействия муравьиной кислоты и аммиака при 30 - 110oС в присутствии добавок воды, взятых в массовом соотношении вода : кислота 1 : 1 - 20 с последующим разложением образующегося формиата аммония при 150 - 180oС в присутствии аммиака, взятого в молярном соотношении кислота : аммиак 1 : 0,1 - 1.

Способ получения -формилированных соединений

Способ получения формамида моно или диметилформамида

Alpha,Alpha disubstituierte N-Cycloalkylalkyl-Benzylamine, Verfahren zu ihrer Herstellung, ihre Anwendung als Arzneimittel und ihre Zwischenprodukte bei der Herstellung.

N-vinyl-formamide preparations useful for prodn of polymers - contain less than 250 ppm formic acid, resulting in good storage stability and suitability for radical polymerisation

N-vinylformamide (NVF) prepns. (I) are claimed, contg. not more than 250 ppm formic acid (II) w.r.t. wt. of NVF. Also claimed are NVF prepns. contg. 1-250 ppm formic acid and 10-100 ppm antioxidant (III). Crude NVF is purified by treatment with alkali (NaOH, MgO, CaCO3, etc.) followed by distn., and/or by treatment with weakly basic ion exchange resin to remove (II) or weakly acid ion exchange resin to remove basic impurities. The prod. can be stored under inert gas at 15 deg.C or below to keep the formic acid content below 250 ppm, or stabilised with (III), pref. 2,6-di-tert.-butyl-p-cresol (IIIA), dl-alpha-tocopherol, etc. USE/ADVANTAGE - Used for the prodn. of NVF polymers by radical polymerisation of (I). NVF polymers are used as dewatering pptn. agents for organic slurries and as chemicals for paper prodn. The invention provides NVF prepns. with excellent storage stability due to their low content of formic acid (formed by oxidative decompsn. of NVF). These prepns. are very suitable ...

PROCESS FOR FORMYLATING ORGANIC BASIC NITROGEN COMPOUNDS

... 1434320 Formylation of organic nitrogen compounds DEUTSCHE GOLD-UND SILBER-SCHEIDEANSTALT 25 April 1974 [14 July 1973] 18136/74 Heading C2C A process for the formylation of an organic basic nitrogen compound comprises formylating the nitrogen compound in the form of a salt, in the presence of acetic anhydride, with an alkali metal formate or ammonium formate in an organic solvent which is substantially immiscible with water. The nitrogen compound and formate are preferably used in stoichiometric amounts, with from 1 to 4 mols. of anhydride per mole of nitrogen compound, at a temperature of from 20‹ to 60‹ C. using an aliphatic, halogenated aliphatic or aromatic hydrocarbon, ether or mixture thereof as the solvent.

CONTINUOUS MANUFACTURE OF FORMAMIDE

BI- AND TRI-NUCLEAR LIQUID CRYSTAL SUBSTANCES

Alkylamine derivatives as antifouling agents.

Use of derived from the malonic acid to delay the growth of the plants.

PROCEDURE FOR THE CLEANING OF POLAR VINYLVERBINDUNGEN

PROCEDURE FOR THE CLEANING OF OXALSAEUREDIAMID.

DERIVATIVES THE OMEGA DIALKYLIERTEN ALKANKARBONSAEUREN, PROCEDURE FOR YOUR PRODUCTION AND USE AS DRUGS.

PRODUCTION OF FORM AMIDE USING NATRIUMDIFORMYLAMID

ORGANIC REACTIONS WITH CO-GENERATING MATERIALEN

VOLATILE ORGANIC BARIUM, STRONTIUM AND CALCIUM CONNECTIONS AND A PROCEDURE FOR THE PRODUCTION OF LAMINATED MATERIALS, THE OXIDES OR FLUORIDES OF BARIUM, STRONTIUM OR CALCIUM FROM THESE CONNECTIONS CONTAINING

ALPHA, ALPHA - DISUBSTITUTED N-CYCLOALKYLALKYLBENZYLAMINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT AND THEIR SYNTHESIS INTERMEDIATES

ESS, THEIR USE AS MEDICINE AND THEIR SYNTHESISING AGENTS

Beta2-adrenoceptor agonists

CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS

This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (see above formula) wherein: A is an aryl group; Q1 is an aryl leader group having a backbone of at least 2 carbon atoms; J is an amide linkage selected from: -NR1C (=O) - and -C (=O) NR1-; R1 is an amido substituent; and, Q2 is an acid leader group; and pharmaceutically acceptable salts, solvates, amides, esters, and ethers, thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and to inhibit conditions such as cancer and psoriasis.

BIOLOGICAL LOW-MOLECULAR-WEIGHT DERIVATIVES

It is pointed out that the existing crosslinking agents and condensing agents having been employed in biological adhesives and in treating medical devices such as cardiac valves, which are non-natural products synthesized artificially, are not metabolized in vivo and exhibit toxicity to living bodies. Therefore, these products can be used only in a restricted amount and for limited purposes in the clinical field. It is intended to provide biological low-molecular weight derivatives obtained by modifying a carboxyl group of a biological low-molecular weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide or derivatives thereof and crosslinked high- molecular weight compounds obtained by crosslinking various high-molecular weight compounds with the use of the above derivative.

PROCESS FOR MAKING LOWER ALKYL FORMAMIDES

CATALYSIS USING SUPPORTED STRONG BASE CATALYSTS

BIPHENYL DERIVATIVES AND THEIR USE AS FUNGICIDES

A fungicidally active compound of formula (I): where Het is a substituted 5- or 6-membered heterocyclic ring; R1 is hydrogen, formyl, CO-C1-4 alkyl, COO-C1- 4 alkyl, C1-4 alkoxy(C1-4)alkylene, CO-C1-4 alkylenoxy(C1-4)alkyl, propargyl or allenyl; R2, R3, R4 and R5 are each, independently, hydrogen, halogen, methyl or CF3; each R6 is, independently, halogen, methyl or CF3; R7 is (Z)mC=C(Y1), (Z)mC(Y1)=C(Y2)(Y3) or tri(C1-4)alkylsilyl; X is O or S; Y1, Y2 and Y3 are each, independently, hydrogen, halogen, C1-6 alkyl [optionally substituted by one or more substituents each independently selected from halogen, hydroxy, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio, C1-4 haloalkylthio, C1-4 alkylamino, di(C1-4)alkylamino, C1-4 alkoxycarbonyl, C1-4 alkylcarbonyloxy and tri(C1-4)alkylsilyl], C2-4 alkenyl [optionally substituted by one or more substituents each independently selected from halogen], C2-4 alkynyl [optionally substituted by one or more substituents each independently selected from halogen ...

POLYMERIC FILM BASE HAVING A COATING LAYER OF ORGANIC SOLVENT BASED POLYMER WITH A FLUORINATED ANTISTATIC AGENT

Polymeric film may be provided with an antistatic coating comprising an oleophilic polymeric film forming binder and a fluorinated ionic polyoxyalkylene antistatic agent in an organic solvent system. The coated film base with the antistatic layer is particularly useful in preventing static problems in photothermographic elements when thermally developed in heated rollers.

Verfahren zur Herstellung von Dialkylformamid-dialkylacetal

COMPOUNDS WITH THERAPEUTIC ACTIVITY, IN PARTICULAR AS ANTI-PHENALEN, COMPOSITIONS CONTAINING THEM AND METHODS FOR THEIR PREPARATION.

НЕПРЕРЫВНЫЙ СПОСОБ ПОЛУЧЕНИЯ АМИДОВ НИЗШИХ АЛИФАТИЧЕСКИХ КАРБОНОВЫХ КИСЛОТ

Изобретение относится к непрерывному способу получения амидов, согласно которому по меньшей мере одна карбоновая кислота формулы I в которой R3 представляет собой водород или необязательно замещённую алкильную группу, содержащую от 1 до 4 атомов углерода, реагирует по меньшей мере с одним амином формулы II в которой R1 и R2 независимо являются водородом или углеводородной группой, содержащей от 1 до 100 атомов, с образованием аммониевой соли, и указанная аммониевая соль затем превращается в амид карбоновой кислоты под действием микроволнового облучения в реакционной трубке, продольная ось которой ориентирована в направлении распространения микроволн одномодовым микроволновым аппликатором.

НЕПРЕРЫВНЫЙ СПОСОБ ПОЛУЧЕНИЯ АМИДОВ НИЗШИХ АЛИФАТИЧЕСКИХ КАРБОНОВЫХ КИСЛОТ

Изобретение относится к непрерывному способу получения амидов, согласно которому по меньшей мере одна карбоновая кислота формулы (I) в которой R3 представляет собой водород или необязательно замещённую алкильную группу, содержащую от 1 до 4 атомов углерода, реагирует по меньшей мере с одним амином формулы (II) в которой R1 и R2 независимо являются водородом или углеводородной группой, содержащей от 1 до 100 атомов с образованием аммониевой соли, и указанная аммониевая соль затем превращается в амид карбоновой кислоты под действием микроволнового облучения в реакционной трубке, продольная ось которой ориентирована в направлении распространения микроволн одномодовым микроволновым аппликатором.

СОЕДИНЕНИЯ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИММУНОМОДУЛЯТОРОВ

Описаны соединения формулы (I) где кольцо А, кольцо В, Rc, q такие, как в формуле изобретения. Также описаны способы применения таких соединений в качестве иммуномодуляторов и фармацевтические композиции, содержащие такие соединения. Данные соединения могут быть использованы для лечения, предупреждения или замедления прогрессирования вирусных заболеваний или расстройств и рака.

AMIDES, USE OF AS SOLVENTS FOR ORGANIC COMPOUNDS, COMPOSITIONS AND EMULSION, CONTAINING AMIDES, AND METHOD OF TREATMENT OF PLANTS

Novel decamethyl zirconocene coordination compound as well as preparation method and application thereof

Azeotropic extraction distillation and liquid-liquid layered integrated separating the sodium salt, dimethyl formamide, the mixed solution of toluene and water method

OXIDATION OF METHYLAMINES N-SUBSTITUEES OUT OF FORMAMIDES N-SUBSTITUES

PROCEDE POUR PREPARER DU DIMETHYLFORMAMIDE

L'invention concerne un procédé pour produire du diméthylformamide. On fait réagir un mélange de monométhylamine et/ou de monométhylformamide et de triméthylamine, ou un tel mélange contenant de plus de la diméthylamine avec du monoxyde de carbone en présence de fer métallique ou d'un composé de fer comme catalyseur et d'hydrogène gazeux dans un rapport en volumes de H2 /CO compris entre 0,05 et 3. L'invention s'applique en particulier à a préparation industrielle de diméthylformamide très pur avec un rendement important et une sélectivité élevée.

PROCESS FOR SEPARATION OF d-2-(6-METHOXY-2-NAPHTHYL)- PROPIONIC ACID FROM RACEMIC MIXTURE

... d-2-(6-Methoxy-2-naphthyl)-propionic acid is prepd. for use as antiphlogistic, antiferbrile. a racemic mixt. of d- and l-2- (6methoxy-2-naphthyl)-propionic acid is dissolved in an organic solvent, such as formamide, monomethylformamide, monoethylformamide, monoethylacetamide, dethylacetamide, at 70 - 90≨C. This soln. is cooled, and cinchonidine salt of d-2-(6-methoxy-2naphthyl)-propionic acid is seeded at 60-64≨C. The crystalized salt is separated, and d- 2-(6-methoxy-2-naphthyl)-propionic acid is recovered. Copyright 1997 KIPO ...

Dye composition for keratinic fibres containing sulfured metaphenylenediamines, dyeing process and new sulfured metaphenylenediamines and preparation method thereof

The invention relates to a dye composition for keratinic fibers comprising an oxidation colorant precursor of the type ortho and/or para and a sulfured metaphenylenediamine having formula (I) см. иллюстрацию в PDF-документе wherein Z is alkyl, aralkyl, monohydroxyalkyl or polyhydroxyalkyl, aryl or aminoalkyl, as well as the acid salts thereof, with the condition that R1 and R2 do not represent simultaneously hydrogen when Z is alkyl or hydroxyalkyl, as well as the acid salts corresponding to the compounds of formula (I).

Process for preparing 1,2-diamino compounds

The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides.

METHOD FOR STABILIZING N-VINYLAMIDE

PURPOSE: To reduce a loss due to polymerization, decomposition, etc., and enhance the stability of N-vinylamide by adding quinones or alkali-modified substances thereof to the N-vinylamide and distilling the resultant mixture. CONSTITUTION: This method for stabilizing N-vinylamide (e.g. N-vinylformamide) is to add quinones (e.g. p-benzoquinone) or alkali-modified substances thereof in an amount of 50-10000ppm expressed in terms of the quinones thereto and distill the resultant mixture. The alkali-modified substances of the quinones are produced by dissolving the quinones in a solvent such as methanol and adding a small amount of caustic soda or caustic potash thereto. Since the alkali-modified substances are nonvolatile and can readily be removed from the N-vinylamide by the distillation, they are suitably used for the stabilization. Thereby, the stability in storage and transportation is enhanced. COPYRIGHT: (C)1996,JPO ...

PREPARATION OF 3-SUBSTUTUTED-2,3-DIHALOGENOPROPIONIC ACID OR DERIVATIVE THEREOF

PURPOSE: To obtain the titled compound useful as a raw material for polymers, etc. quantitatively, only by the direct halogenation of a 3-substituted-acrylic acid or its derivative, without light, in the presence of monohydrogenphosphate of an alkali (earth) metal as a catalyst. CONSTITUTION: A 3-substituted-acrylic acid or its derivative is directly halogenated with a halogenating agent in the liquid phase in a solvent without light in the presence of monohydrogenphosphate of an alkali (earth) methal, e.g. disodium hydrogenphosphate, as a catalyst, to give a 3-substituted-2,3-dihalogenopropionic acid or its derivative, e.g. methyl 2,3-dichloropropionate. EFFECT: The used catalyst may be readily recovered and reused by the alkali treatment. The reaction without light needs no specific apparatus. USE: A raw material for a physiological activator, e.g. an amino acid, medicine or agricultural chemical. COPYRIGHT: (C)1981,JPO&Japio ...

СПОСОБ ПОЛУЧЕНИЯ МЕТАХЛОРБЕНЗГИДРИЛФОРМАМИДА

Сущность изобретения: продукт-метахлорбензгидрилформамид. Реагент 1: мочевина или N-метилмочевина в 94-99,7% НООС. Реагент 2: хлорзамещенный бензофенон. Условия реакции: при нагревании сначала при 120°С, а затем при 185°С, при молярном соотношении метахлорбензофенон мочевина (N-метилмочевина) НООС, равном 1:8,0(1,5-3,5):8,5-15. 4 табл.

СПОСОБ ПОЛУЧЕНИЯ N-МЕТИЛФОРМАМИДА

Изобретение относится к получению N-метилформамида. Способ осуществляют путем взаимодействия муравьиной кислоты и метиламина через образование промежуточной соли формиата метиламмония с последующей дегидратацией соли с использованием катализатора на основе триоксида молибдена, растворенного в водном метиламине, который вводят в муравьиную кислоту в количестве 2,0-4,0 мас.% от последней. Процесс ведут в реакторе, заполненном инертной насадкой с развитой поверхностью, без охлаждения реакционной массы в течение 1-2 часов с последующей отгонкой летучих продуктов при температуре в кубе до 190°С в течение 60-90 мин. Кубовый остаток, содержащий катализатор, после выделения целевого продукта возвращают в реактор. Технический результат - снижение длительности процесса, сокращение энергозатрат на проведение процесса, повышение качества и выхода целевого продукта и снижение отходов производства. 2 з.п. ф-лы.

Способ стабилизации диметилформамида

2,2-DIMETHYLPROPANE ISONITRILE DERIVATIVES POSSESSING SYNERGISTIC ACTIVITY TOWARDS INSECTICIDES, AND 2,2-DIMETHYLPROPANE FORMAMIDE DERIVATIVES AS INTERMEDIATE PRODUCTS FOR OBTAINING 2,2-DIMETHYLPROPANE ISONITRILE DERIVATIVES

Способ получения замещенных формамидов

Способ получения производных формамида

Изонитрильные производные 2,2-диметилпропана, обладающие синергической активностью к инсектицидам, и формамидные производные 2,2-диметилпропана в качестве промежуточных продуктов для получения изонитрильных производных 2,2-диметилпропана

Изобретение используется в сельском хозяйстве, так как проявляет синергическую активность к инсектицидам. Сущность: новые химические вещества - изонитрильные производные 2,2-диметилформамида формулы: R-CH(CN)-C(CH3)2-CH3-R- СбН5СбН40СН2 (а) CbCliJiCH5-OH C. (б) БФ: R -(a-) Ci9H2iNO, т.пл. 115-117°С; БФ: Р - (б) Ci2Hi4ClNS, светло-желтое масло и формамидные производные 2,2-диметил- пропана формулы: R-CH(NHC/0/H)- С(СН3)з, R Ci-CH-CB-CH-CH-CH-CH (A), R СбН5СбН40СН2-(Б) БФ:Р -(А)С12Н1бС М05, т.пл. 104-105°С; БФ: R1 -(Б). CigH23N02, т.пл. 151-152°С для получений изонитрильных производных . 2 с.п.ф-лы, 1 табл. сл с ...

Способ получения N-метилформамида

Сущность изобретения: продукт - N-ме- тилформамид СНзМНСНО, т.кип. 100- 101°С/40 мм, по20 1,4320. Реагент 1: НС-ООН. Реагент 2: СНзМН. Условия реакции: реагенты в эквимолярном соотношении нагревают с одновременной отгонкой летучих веществ до 180-186°С, затем - до 190-200°С так/чтобы температура паров летучих веществ не превышала 100-105°С.

ALPHA,ALPHA DISUBSTITUIERTE N-CYCLOALKYLALKYL-BENZYLAMINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE ANWENDUNG ALS ARZNEIMITTEL UND IHRE ZWISCHENPRODUKTE BEI DER HERSTELLUNG.

Purification of tertiary formamide contaminated with tertiary acetamide

A chlorinating agent such as a chloroiminium species is used to remove or neutralize tertiary acetamide present as a contaminant in a tertiary formamide solvent. Tertiary formamide solvent purified or treated in this manner can be used as a reaction vehicle for the chlorination of sucrose-6-acylates, thereby improving the yields of the desired sucralose-6-acylate (an intermediate in the production of sucralose).

1-arylcyclobutylalkylamine compounds useful as therapeutic agents

Compounds of formula I in which n=0 or 1; R1 is C1- alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, cycloalkylalkyl or optionally substituted phenyl when n=0 or R1 is H or C1-3 alkyl when n=1, R2 is H or C1-3 alkyl, R3 and/or R4 are H, formyl, C1-3 alkyl, C3-6 alkenyl, C3-6 alkynyl, C3-7 cycloalkyl or R3 and R4 together with the nitrogen atom form a heterocyclic ring system; R5 and/or R6 are H, halo, CF3, C1-3 alkyl, C1-3 alkoxy, C1-3 alkylthio or R5 and R6 together with the carbon atoms to which they are attached form a second benzene ring and R7 and/or R8 are H or C1-3 alkyl show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.

PROCESS FOR MAKING AN AMIDE OF FORMIC ACID AND FORMING A NITRODIARYLAMINE THEREFROM

PROCEDURE FOR THE CONTINUOUS DISTILLATION OF THERMALUNSTABLE MONOMERS

PACKING ELEMENT

LIQUID CRYSTAL SUBSTANCE

VERFAHREN ZUR HERSTELLUNG VON NEUEN ARYLCYCLOBUTYLALKYLAMINEN

PROCEDURE FOR FORMYLIERUNG

WABENFOERMIGER CATALYST, ITS PRODUCTION AND ITS USE.

NEW MALONIC ACID DERIVATIVES AND COMPOSITIONS, IT CONTAINING, FOR THE DELAY OF PLANT GROWTH.

PROCEDURE FOR FORMYLIERUNG

PROCEDURE FOR THE PRODUCTION OF NEW ARYLCYCLOBUTYLALKYLAMINEN

LIQUID CRYSTAL SUBSTANCE

ALKANDIYL UNTIL CARBONAMIDE, ADHAESIVKOMPONENTEN MATERIALS FOR APPLICATION, KOLLAGENHALTIGER FOR TREATMENT, CONTAINING IN THE MEDICINE, THESE CONNECTIONS.

BIPHENYL DERIVATIVES AND THEIR USE AS FUNGICIDES

MALONIC ACID DERIVATIVE COMPOUNDS

Beta2-adrenoceptor agonists

Amides, use of amides as solvents for organic compounds, compositions and emulsions containing amides, and method for treating a plant

The present invention relates in general to the use of amides of the following general formula (I) wherein R is a linear or branched hydrocarbyl group containing 9 to 14 carbon atoms; R is selected from the group consisting of methyl, ethyl and benzyl; and R is selected from the group consisting of hydrogen, methyl and ethyl, as solvents for organic agriculturally active ingredients, compositions comprising organic agriculturally active ingredients and such amides, methods for treating a plant utilizing such compositions, as well as some of the amides as such and methods for their production.

FORMYLATION PROCESS

THERAPEUTIC AGENTS

RECYCLING CATALYST IN PREPARATION OF DIMETHYLFORMAMIDE FROM DIMETHYLAMINE AND CARBON MONOXIDE

TITLE Recycling Catalyst in Preparation of Dimethylformamide from Dimethylamine and Carbon Monoxide The alkali metal methylate catalyst used in the preparation of dimethylformamide from dimethylamine and carbon monoxide can be preserved, recycled and reused is the reaction mass contains dimethylamine in excess of the stoichiometric amount at all times. CH 1115 ...

METHOD FOR PRODUCING MONOMETHYLFORMAMIDE AND DIMETHYLFORMAMIDE

OF THE ENCLOSURE Monomethylformamide and dimethylformamide are produced by the catalytic reaction of formamide and methanol, using a quarternary ammonium compound as the catalyst H-1111 ...

HYBRID PEROVSKITE MATERIAL PROCESSING

A method for preparing photoactive perovskite materials. The method comprises the steps of: introducing a lead halide and a first solvent to a first vessel and contacting the lead halide with the first solvent to dissolve the lead halide to form a lead halide solution, introducing a Group 1 metal halide a second solvent into a second vessel and contacting the Group 1 metal halide with the second solvent to dissolve the Group 1 metal halide to form a Group 1 metal halide solution, and contacting the lead halide solution with the Group 1 metal halide solution to form a thin-film precursor ink. The method further comprises depositing the thin-film precursor ink onto a substrate, drying the thin-film precursor ink to form a thin film, annealing the thin film; and rinsing the thin film with a salt solution.

OXIDATION OF N-SUBSTITUTED METHYLAMINES TO N-SUBSTITUTED FORMAMIDES

PROCESS FOR THE PRODUCTION OF FORMAMIDES

BIPHENYL DERIVATIVES AND THEIR USE AS FUNGICIDES

A fungicidally active compound of formula (I): where Het is a substituted 5- or 6-membered heterocyclic ring; R1 is hydrogen, formyl, CO-C1-4 alkyl, COO-C1- 4 alkyl, C1-4 alkoxy(C1-4)alkylene, CO-C1-4 alkylenoxy(C1-4)alkyl, propargyl or allenyl; R2, R3, R4 and R5 are each, independently, hydrogen, halogen, methyl or CF3; each R6 is, independently, halogen, methyl or CF3; R7 is (Z)mC=C(Y1), (Z)mC(Y1)=C(Y2)(Y3) or tri(C1-4)alkylsilyl; X is O or S; Y1, Y2 and Y3 are each, independently, hydrogen, halogen, C1-6 alkyl [optionally substituted by one or more substituents each independently selected from halogen, hydroxy, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio, C1-4 haloalkylthio, C1-4 alkylamino, di(C1-4)alkylamino, C1-4 alkoxycarbonyl, C1-4 alkylcarbonyloxy and tri(C1-4)alkylsilyl], C2-4 alkenyl [optionally substituted by one or more substituents each independently selected from halogen], C2-4 alkynyl [optionally substituted by one or more substituents each independently selected from halogen ...

PROCESS FOR THE PREPARATION OF SUBSTITUTED FORMAMIDES

Substituted formamides are prepared by the oxidation of amines in the presence of a catalyst.

CONTINUOUS METHOD FOR PRODUCING AMIDES OF LOW ALIPHATIC CARBOXYLIC ACIDS

The invention relates to a continuous method for producing amides, according to which at least one carboxylic acid of formula (I) R3-COOH (I), wherein R3 is hydrogen or an optionally substituted alkyl group comprising between 1 and 4 carbon atoms, is reacted with at least one amine of formula (Il) HNR1R2 (II), wherein R1 and R2 are independently hydrogen or a hydrocarbon group comprising between 1 and 100 C atoms, to form an ammonium salt, and said ammonium salt is then reacted to form a carboxylic acid amide, under microwave irradiation in a reaction pipe, the longitudinal axis of the pipe being oriented in the direction of propagation of the microwaves of a monomode microwave applicator.

METHOD FOR PRODUCING VINYLAMINE UNIT-CONTAINING POLYMER AND POLYMERIZATION PRODUCT

The present invention relates to a method for producing a vinylamine unit-containing polymer, the method comprising: preparing a mixture for polymerization (a) containing N-vinylformamide as a monomer component by using crude N-vinylformamide which contains the N-vinylformamide and formamide and has a content of the formamide of 1 part by mass or more with respect to 100 parts by mass of the N-vinylformamide; obtaining a polymerization product (b) containing an N-vinylformamide unit-containing polymer and formamide by polymerizing the monomer component in the mixture for polymerization (a); and obtaining a hydrolysis product (c) containing a vinylamine unit-containing polymer through a hydrolysis treatment of the polymerization product (b) using an acid or a base.

R(+)-N-FORMYL-PROPARGYL-AMINOINDAN

The subject invention provides R (+) -N-formyl-propargyl- aminoindan and a composition containing N-propargyl-1 (R) -aminoindan or a pharmaceutically acceptable salt thereof, and a compound of R (+) -N-formyl-propargyl-aminoindan.

POLYMERIC FILM BASE HAVING A COATING LAYER OF ORGANIC SOLVENT BASED POLYMER WITH A FLUORINATED ANTISTATIC AGENT

Polymeric film may be provided with an antistatic coating comprising an oleophilic polymeric film forming binder and a fluorinated ionic polyoxyalkylene antistatic agent in an organic solvent system. The coated film base with the antistatic layer is particularly useful in preventing static problems in photothermographic elements when thermally developed in heated rollers.

БИФЕНИЛЬНЫЕ ПРОИЗВОДНЫЕ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ФУНГИЦИДОВ

В изобретении описано фунгицидно активное соединение формулы (I) в которой Het обозначает замещенное 5- или 6-членное гетероциклическое кольцо; R1 обозначает водород, формил, СО-С1-С4алкил, СОО-С1-С4алкил., C1-С4алкокси(С1-С4)алкилен, СО-С1-С4алкиленокси(С1-С4)алкил, пропаргил или алленил; все R2, R3, R4 и R5 независимо обозначают водород, галоген, метил или CF3; все R6 независимо обозначают галоген, метил или CF3; R7 обозначает (Z)mC≡C(Y1), (Z)mC(Y1)=C(Y2)(Y3) или три(С1-С4)алкилсилил; X обозначает О или S; все Y1, Y2 и Y3 независимо обозначают водород, галоген, С1-С6алкил (необязательно содержащий один или большее количество заместителей, независимо выбранных из группы, включающей галоген, гидроксигруппу, C1-С4алкоксигруппу, С1-С4галогеналкоксигруппу, С1-С4алкилтиогруппу, C1-С4галогеналкилтиогруппу, С1-С4алкиламиногруппу, ди(С1-С4)алкиламиногруппу, С1-С4алкоксикарбонил, С1-С4алкоксикарбонилоксигруппу и три(С1-С4)алкилсилил), С2-С4алкенил (необязательно содержащий один или большее количество ...

COMPOUNDS FOR USE AS IMMUNOMODULATORS

АМИДЫ, ПРИМЕНЕНИЕ АМИДОВ В КАЧЕСТВЕ РАСТВОРИТЕЛЕЙ ДЛЯ ОРГАНИЧЕСКИХ СОЕДИНЕНИЙ, КОМПОЗИЦИИ И ЭМУЛЬСИИ, СОДЕРЖАЩИЕ АМИДЫ, И СПОСОБ ОБРАБОТКИ РАСТЕНИЯ

Изобретение относится в целом к применению амидов следующей общей формулы (I), в которой R1 является линейной или разветвленной углеводородной группой, содержащей от 9 до 14 углеродных атомов; R2 выбран из группы, состоящей из метила, этила и бензила; и R3 выбран из группы, состоящей из водорода, метила и этила; в качестве растворителей для органических в области сельского хозяйства активных ингредиентов, композициям, содержащим органические приемлемые в области сельского хозяйства активные ингредиенты и такие амиды, способам обработки растения, используя такие композиции, а также к некоторым амидам как таковым, и к способам их получения.

БИФЕНИЛЬНЫЕ ПРОИЗВОДНЫЕ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ФУНГИЦИДОВ

В заявке описано фунгицидно активное соединение формулы (I) в которой Het обозначает замещенное 5- или 6-членное гетероциклическое кольцо; R1 обозначает водород, формил, CO-C1-C4алкил, COO-C1-C4алкил, C1-C4алкокси(C1-C4)алкилен, CO-C1-C4алкиленокси(C1-C4)алкил, пропаргил или алленил; все R2, R3, R4 и R5 независимо обозначают водород, галоген, метил или CF3; все R6 независимо обозначают галоген, метил или CF3; R7 обозначает (Z)mC≡C(Y1), (Z)mC(Y1)=C(Y2)(Y3) или три(C1-C4)алкилсилил; X обозначает O или S; все Y1, Y2 и Y3 независимо обозначают водород, галоген, C1-C6алкил [необязательно содержащий один или большее количество заместителей, независимо выбранных из группы, включающей галоген, гидроксигруппу, C1-C4алкоксигруппу, C1-C4галогеналкоксигруппу, C1-C4алкилтиогруппу, C1-C4галогеналкилтиогруппу, C1-C4алкиламиногруппу, ди(C1-C4)алкиламиногруппу, C1-C4алкоксикарбонил, C1-C4алкоксикарбонилоксигруппу и три(C1-C4)алкилсилил], C2-C4алкенил [необязательно содержащий один или большее количество ...

Method for preparing methallyl alcohol and amide simultaneously

Method of preventing evaporator from crystallizing in process of preparing N,N-dimethyl formamide and crystallizing-proof evaporator

Methanol recovery treatment process for formamide production

Rectification system is imitated to seven towers no. 5 of direct memory access C or DMF waste liquid

The utility model discloses a rectification system is imitated to seven towers no. 5 of direct memory access C and DMF waste liquid, including first concentration tower, second concentration tower, third concentration tower, fourth concentration tower, fifth concentration tower, rectifying column and deacidification tower, five recovery methods of imitating rectification system in seven towers that also disclose a direct memory access C and DMF waste liquid are created in the invention, the recovery processing, the height that include direct memory access C and DMF waste liquid the boil recovery processing of thing and solid -state thing, the recycle of water and the recycle of steam. Direct memory access C is created in the invention and DMF carries out the concentration within 100 DEG C, carries out rectification and deacidification within 105 DEG C, and whole process all carryes out under low temperature, and direct memory access C and DMF basically do not decompose, direct memory access ...

OXIDATION OF METHYLAMINES N-SUBSTITUEES OUT OF FORMAMIDES N-SUBSTITUES

METHYL ACETOACETIC ESTER ENAMINE OF D-2- 1,4-CYCLOHEXADIEN-1-YL GLYCINE SODIUM SALT

PROCESS FOR PREPARING NITROGEN CONTAINING ORGANIC COMPOUNDS

Process for formylation

PROCESS FOR THE CONTINUOUS PREPARATION OF FORMAMIDE

Process for the production of ralfinamide salts substantially free from impurities having genotoxic effects

The invention relates to a new process for the production and/or purification of the salt of the compound (S)-2-[4-(2-fluorobenzyloxy)benzylamino]propanamide, i.e. ralfinamide, or the respective R-enantiomer, with methanesulfonic acid in high yields and very high enantiomeric and chemical purity in the form of the crystalline anhydrous polymorph identified as form A, wherein said salt is substantially free from impurities having genotoxic effect, such as (C1-C5) alkanylmethanesulfonates, and residual solvents known as potential precursors thereof, such as (C1-C5) alkanols or esters thereof with lower alkanoic acids. The process foresees (i) production and/or crystallization of the salt, from water, acetone, an aliphatic ketone of 4-5 carbon atoms or mixtures thereof with water, or (ii) slurring the solid salt with (a) water, (b) a mixture of water with acetone or an aliphatic ketone of 4-5 carbon atoms, (c) acetone, an aliphatic ketone of 4-5 carbon atoms or a mixture thereof, or (iii) ...

Method for producing n-vinylformamide

A method for producing N-vinylformamide through a vapor-phase thermal decomposition reaction using an evaporator (10) for evaporating a raw material, a thermal decomposition reactor (20) for thermally decomposing a raw material gas generated by the evaporator (10) and a condenser (30) for condensing a thermally decomposed gas generated by the thermal decomposition reactor (20), wherein the evaporation of the raw material is started in the evaporator (10) while the temperature of a tube wall of a first connection tube (40) that connects the evaporator (10) to the thermal decomposition reactor (20) satisfies a requirement represented by formula (1): (temperature of tube wall (° C.))≥0.37×(pressure of evaporator (mmHg))+205.

ANALOGS OF 3-AMINO-4-(PROPAN-2-YLIDENE)CYCLOPENTANE-1-CARBOXYLIC ACID AND USES THEREOF FOR TREATING DISEASES AND DISORDERS ASSOCIATED WITH ORNITHINE AMINOTRANSFERASE ACTIVITY

Disclosed are compound and methods of using the compounds for modulating ornithine aminotransferase (OAT) activity. The disclosed compound are characterized as analogs of 3-amino-4-(propan-2-ylidene)cyclopentane-1-carboxylic acid which may be formulated as therapeutic agents for treating diseases and disorders associated with ornithine aminotransferase (OAT) activity such as hepatocellular carcinoma and other cancers. 2. The compound of claim 1 , wherein Ris trifluoromethyl.8. A pharmaceutical composition comprising: (i) a compound of ; and (ii) a carrier claim 1 , excipient claim 1 , or diluent.9. The pharmaceutical composition of claim 8 , wherein the pharmaceutical composition comprises an effective amount of the compound for treating a disease or disorder associated with omithine aminotransferase activity.10. The pharmaceutical composition of claim 8 , wherein the pharmaceutical composition comprises an effective amount of the compound for treating a cell proliferative disease or disorder associated with omithine aminotransferase activity claim 8 , optionally wherein the cell proliferative disease or disorder is hepatocellular carcinoma.11. A method for treating a disease or disorder associated with omithine transferase activity in a subject in need thereof claim 1 , the method comprising administering to the subject the compound of .12. The method of claim 11 , wherein the disease or disorder associated with omithine transferase activity is cancer.13. The method of claim 11 , wherein the disease or disorder associated with omithine transferase activity is hepatocellular carcinoma.14. The method of claim 11 , wherein the compound or the pharmaceutical composition are administered orally.15. The method of claim 11 , wherein the compound or the pharmaceutical composition are administered at a dose that delivers between about 32 mg compound/60 kg subject/day and 200 mg compound/60 kg subject/day.17. The compound of claim 16 , wherein Ris trifluoromethyl. The ...

Process for obtaining biobased N-vinylformamide

La présente invention concerne un procédé d’obtention de N-vinylformamide comprenant la réaction entre un acétaldéhyde et une formamide, l’un des deux, préférentiellement les deux, étant au moins en partie d’origine renouvelable et non fossile. L’invention concerne également un monomère N-vinylformamide biosourcé, un polymère biosourcé incorporant au moins ledit monomère et l’utilisation dudit polymère dans différents domaines techniques. The present invention relates to a process for obtaining N-vinylformamide comprising the reaction between an acetaldehyde and a formamide, one of the two, preferably both, being at least partly of renewable and non-fossil origin. The invention also relates to a biobased N-vinylformamide monomer, a biobased polymer incorporating at least said monomer and the use of said polymer in various technical fields.

Synthesis of N-vinyl formamide

A process to produce N-vinylformamide includes the steps of: reacting hydroxyethyl formamide with a reactant comprising at least one cyclic anhydride group to form an ester, and dissociating the ester via heat in a thin film evaporation to synthesize N-vinylformamide and a compound comprising at least one diacid group, the N-vinylformamide separating from the diacid during the thin film evaporation. The reactant including at least one cyclic anhydride group can, for example, be succinic anhydride, maleic anhydride, phthalic anhydride, (2-docecen-1-yl)succinic anhydride, exo-3,6-epoxy-1,2,3,6 -tetrahydrophthalic anhydride or a polymer including at least one cyclic anhydride group. A process to produce N-vinylformamide comprises the steps of: mixing acetaldehyde, formamide and a source of anhydride in a single reaction vessel, reacting the acetaldehyde, formamide and the source of anhydride in the reaction vessel under pressure, dissociating an ester formed by a reaction between the source of anhydride and hydroxyethyl formamide formed in the reaction vessel to synthesize N-vinylformamide and a compound comprising at least one diacid group.

Amidoadamantanes and method for producing the same

The invention relates to 1-formamido-adamantane derivatives of formula (I), which carry the substituents R1, R2 or R3 in 3, 5 and/or 7 position, the substituents being defined as follows: hydrogen, a linear or branched alkyl, alkenyl or alkinyl group with up to 6 C atoms, an aliphatic or aromatic, cyclic or heterocyclic hydrocarbon group with up to 10 carbon atoms, and formamides of hydrocarbons from the group of diamondoids, for example diamantane, triamantane, tetramantane and pentamantane, however, with the exception of 1-formamido-3,5-dimethyladamantane. The invention also relates to a method for the direct formation of formamide or acetamide of adamantane, adamantane derivatives with the aforementioned definition of substituents or of a hydrocarbon from the group of diamondoids, characterized by reacting the adamantane, the adamantane derivative or the diamondoid with formamide, acetamide or acetonitrile in concentrated acids, while avoiding SO3 containing sulfuric acid or 100% azotic acid.

Method for producing N-vinylformamide

原料を蒸発させる蒸発器（１０）、前記蒸発器（１０）により発生した原料ガスを熱分解する熱分解反応器（２０）、および前記熱分解反応器（２０）により得られる熱分解ガスを凝縮する凝縮器（３０）を用い、気相熱分解反応によりＮ−ビニルホルムアミドを製造する方法であって、前記蒸発器（１０）と前記熱分解反応器（２０）とを連結する第一の接続配管（４０）の管壁の温度が、下記式（１）を満たした状態で、前記蒸発器（１０）において前記原料の蒸発を開始する、Ｎ−ビニルホルムアミドの製造方法。式（１）：管壁温度（℃）≧０．３７×蒸発器圧力（ｍｍＨｇ）＋２０５ An evaporator (10) for evaporating the raw material, a pyrolysis reactor (20) for pyrolyzing the source gas generated by the evaporator (10), and a pyrolysis gas obtained by the pyrolysis reactor (20) are condensed. The first connection for connecting the evaporator (10) and the pyrolysis reactor (20) is a method for producing N-vinylformamide by vapor phase pyrolysis using a condenser (30) A method for producing N-vinylformamide, wherein evaporation of the raw material is started in the evaporator (10) in a state where the temperature of the pipe wall of the pipe (40) satisfies the following formula (1). Formula (1): Tube wall temperature (° C.) ≧ 0.37 × Evaporator pressure (mmHg) +205

Process for the preparation of n-methyl-1-naphthalenemethanamine

The present invention discloses an improved and impurity-free process for the preparation of N-methyl-1-naphthalenemethanamine of formula (I) starting from 1-chloromethylnaphthalene of formula (III). N-methylformamide is reacted with a strong base in N,N-dimethylformamide and/or non-polar solvent to get its anion and this anion is reacted with 1-chloromethylnaphthalene to get the formamide derivative of formula (VI). Alternatively, N-methylformamide (without generating the anion separately) and 1-chloromethylnaphthalene can be reacted together in the presence of a mild base and a phase transfer catalyst in N,N-dimethylformamide and/or a non-polar solvent to get the required formamide of formula (VI). The compound of formula (VI) on acid or base hydrolysis gave the required compound of formula (I). The main advantages of the present invention are it involves simple, economical, and easy to adopt process on a commercial scale. No tertiary-amine impurity is formed in this process. Compound of formula (I) is a key intermediate used in the synthesis of anti-fungal drug, terbinafine of formula (II).

Process for the direct formamidation or acetamidation of admantane and Admantanderivaten and their use for the production of Aminoadmantanen

Verfahren zur direkten Formamidierung oder Acetamidierung von Adamantan oder von einem Adamantanderivat der Formel II das in 3, 5 und/oder 7-Stellung die Substituenten R 1 , R 2 oder R 3 trägt, die die folgenden Bedeutungen haben: Wasserstoff, ein alipathischer Kohlenwasserstoffrest mit bis zu 10 Kohlenstoffatomen, insbesondere eine lineare oder verzweigte Alkyl-, Alkenyl- oder Alkinylgruppe mit bis zu 6 C-Atomen, ein aromatischer, zyklischer oder heterozyklischer Kohlenwasserstoffrest mit bis zu 10 Kohlenstoffatomen, oder von einem Kohlenwasserstoff aus der Reihe der Diamantoide dadurch gekennzeichnet, dass man das Adamantan, das Adamantanderivat oder das Diamantoid ohne vorherige Halogenierung mit Formamid oder Acetamid mit 30 bis 70%-iger Salpetersäure und mit 90 bis 100%-iger Schwefelsäure, aber unter Vermeidung von SO 3 -haltiger Schwefelsäure bei –40 bis +50°C umsetzt und bei direkter Formamidierung ein 1-Formamido-adamantanderivat nach Formel I mit den Substituenten R 1 , R 2 oder R 3 in 3, 5 und/oder 7-Stellung mit den Bedeutungen gemäß der Formel II entsteht, wobei... Process for the direct formamidation or acetamidation of adamantane or of an adamantane derivative of the formula II in the 3, 5 and / or 7-position carries the substituents R 1 , R 2 or R 3 , which have the following meanings: Hydrogen, an aliphatic hydrocarbon radical having up to 10 carbon atoms, in particular a linear or branched alkyl, alkenyl or alkynyl group having up to 6 carbon atoms, an aromatic, cyclic or heterocyclic hydrocarbon radical having up to 10 carbon atoms, or of a hydrocarbon from the series of diamondoids characterized in that the adamantane, the adamantane derivative or the diamondoid without prior halogenation with formamide or acetamide with 30 to 70% nitric acid and 90 to 100% sulfuric acid, but with avoiding SO 3 -containing sulfuric acid at -40 to + 50 ° C and direct Formamidierung a 1-formamido-adamantanderivat according to formula I. with the substituents R 1 , R ...

Verfahren zur Herstellung von N-Vinylverbindungen

一种两亲性碳量子点稳泡剂及其制备方法

本发明公开一种两亲性碳量子点稳泡剂及其制备方法、应用，涉及油气开发技术领域；所述稳泡剂的化学式为·‑CONH‑C 18 H 34 ，该稳泡剂的制备方法包括以下步骤：S1：按照配方称取柠檬酸和油胺，并将柠檬酸搅拌升温加热至熔融，得到熔融的柠檬酸；S2：向熔融的柠檬酸中通入氮气，排出熔融的柠檬酸中的氧气；S3：向除氧之后的柠檬酸中滴加油胺，加热搅拌，并冷凝回流得到稳泡剂。本发明公开的两亲性碳量子点稳泡剂采用柠檬酸和油胺在熔融条件下冷凝回流反应得到的，其泡沫稳定性好，且原材料价格低廉，易于获得。

Synthesis of n-vinyl formamide

一种两亲性碳量子点稳泡剂及其制备方法

本发明公开一种两亲性碳量子点稳泡剂及其制备方法、应用，涉及油气开发技术领域；所述稳泡剂的化学式为·‑CONH‑C 18 H 34 ，该稳泡剂的制备方法包括以下步骤：S1：按照配方称取柠檬酸和油胺，并将柠檬酸搅拌升温加热至熔融，得到熔融的柠檬酸；S2：向熔融的柠檬酸中通入氮气，排出熔融的柠檬酸中的氧气；S3：向除氧之后的柠檬酸中滴加油胺，加热搅拌，并冷凝回流得到稳泡剂。本发明公开的两亲性碳量子点稳泡剂采用柠檬酸和油胺在熔融条件下冷凝回流反应得到的，其泡沫稳定性好，且原材料价格低廉，易于获得。