СПОСОБ ПОЛУЧЕНИЯ ЭФИРОВ АЛКИНИЛКАРБОНОВЫХ КИСЛОТ

Сущность изобретения: продукт-эфиры алкинилкарбоновых кислот ф-лы RC ≡ CCOOR′ , где R - низший алкил, фенил; R′ - низший алкил. Выход 75,0 - 86,9%. Реагент 1: алкин RC ≡ CH . Реагент 2: оксид углерода. Условия реакции: в присутствии кислорода, одноатомного спирта, катализатора-монохлорида меди и хлорида палладия, при 11 - 26oС и концентрации хлорида палладия -0,0014 - 0,0064 моль/л, монохлорида меди 0,2 - 0,5 моль/л и отношении Рсо/Р02 - 0,67 - 2,1. 1 табл.

Промышленный микробицид

MORE OCTADIENYLAETHER AND PROCEDURES FOR THE PRODUCTION OF OCTADIENYLAETHERN.

7-SUBSTITUIERTE of DERIVATIVES of the 3,5-DIHYDROXYHEPT-6 INSAEURE, PROCEDURE FOR ITS PRODUCTION, THEIR USE AS DRUGS, AS WELL AS INTERMEDIATE PRODUCTS.

Procedure for the production of insatiated connections

EICOSATRIYNOIC ACID ESTERS AND AMIDES

Method for the synthesis of DHA

A method for preparing docosahexaenoic acid (DHA). The method comprises coupling a compound represented by Formula I with a compound represented by Formula II followed by partial hydrogenation to obtain a compound represented by Formula III. The compound represented by Formula III acts as a DHA precursor and thus can be hydrolysed to obtain DHA. Novel starting materials represented by Formula I and Formula II, and synthetic routes for preparing the same are also provided.

A SYNTHETIC METHOD OF A-KETOL UNSATURATED FATTY ACIDS

A method of efficiently synthesizing an .alpha.-ketol unsaturated fatty acid having a double bond at the .beta.-position of the ketone moiety. The method is characterized by reacting a mono-substituted acetylene (2) with an epoxy compound (3) to synthesize a compound (4) and synthesizing an .alpha.-ketol unsaturated fatty acid (1) from the compound (4), as shown in the reaction formula (1). Reaction formula (1) (2) (3) (4) (1) (R1 is C1-18 alkyl or a C2- 18 aliphatic hydrocarbon group having one to five double or triple bonds; R2 is a hydroxyl-protecting group; R3 is a carboxyl-protecting group; R is the same as R1, provided that when R1 contains one or more triple bonds, then R is an aliphatic hydrocarbon group in which the triple bonds have been converted to double bonds; and A is C1-18 alkylene.) ...

Verfahren zur Herstellung von ungesättigten Verbindungen

Elément photosensible récepteur d'images

VERFAHREN ZUR HERSTELLUNG NEUER UNGESAETTIGTER VERBINDUNGEN.

A non-isocyanate curing mode method for preparing GAP-based elastomer

ESTERS ET AMIDES DE L'ACIDE EICOSATRIYNOIQUE ET LEUR APPLICATION EN PHARMACIE ET EN COSMETIQUE

ESTERS ET AMIDES DE L'ACIDE EICOSATRIYNOIQUE ET LEUR APPLICATION EN PHARMACIE ET EN COSMETIQUE. 1.COMPOSE CARACTERISE PAR LE FAIT QU'IL REPOND A LA FORMULE:DANS LAQUELLE R EST UN GROUPEMENT ALCOXY INFERIEUR EN C-C OU CYCLOALCOXY EN C-C, SUBSTITUES PAR UN OU PLUSIEURS GROUPEMENTS HYDROXYLES ETOU INTERROMPU PAR UN OU PLUSIEURS HETEROATOMES CHOISIS PARMI L'OXYGENE ET LE SOUFRE, UNGROUPEMENT AMINO DE STRUCTURE -N R R DANS LAQUELLE R OU R IDENTIQUES OU DIFFERENTS DESIGNENT UN ATOME D'HYDROGENE, UN RADICAL ALKYLE INFERIEUR EN C-C LINEAIRE OU RAMIFIE, EVENTUELLEMENT INTERROMPU PAR UN OU PLUSIEURS HETEROATOMES CHOISIS PARMI L'OXYGENE, LE SOUFRE, L'AZOTE, CE RADICAL ALKYLE POUVANT ETRE SUBSTITUE PAR UN OU PLUSIEURS GROUPEMENTS HYDROXYLES, OU BIEN R ET R FORMENT ENSEMBLE AVEC L'ATOME D'AZOTE, UN HETEROCYCLE CONTENANT EVENTUELLEMENT COMME HETEROATOME SUPPLEMENTAIRE DE L'OXYGENE, DU SOUFRE OU DE L'AZOTE, L'UN DES RADICAUX R OU R POUVANT ENCORE DESIGNER, LORSQUE L'AUTRE EST UN ATOME D'HYDROGENE, UN ...

PARA-HYDROGEN LABELLED AGENTS AND THEIR USE IN MAGNETIC RESONANCE IMAGING

The invention provides a method of magnetic resonance investigation of a sample, said method comprising: (i) reacting para-hydrogen enriched hydrogen with a hydrogenatable MR imaging agent precursor containing a non-hydrogen non-zero nuclear spin nucleus to produce a hydrogenated MR imaging agent; (ii) administering said hydrogenated MR imaging agent to said sample; (iii) exposing said sample to radiation of a frequency selected to excite nuclear spin transitions of said non-zero nuclear spin nucleus in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of said non-zero nuclear spin nucleus from said sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from said detected signals.

PHOTOSENSITIVE POLYACETYLENIC SYSTEM AND METHOD OF EXPOSURE

PROPIOLSAEUREESTER UND IHRE VERWENDUNG ALS MIKROBIZIDE

MORE EICOSATRIYNESTER AND AMIDES AND THEIR USE IN PHARMACY AND COSMETICS.

NOVEL CYCLOPENTENEDIONE ANTIFUNGAL COMPOUNDS AND METHODS FOR THEIR USE

Novel compounds and methods useful in the control, treatment, and prevention of fungal activity.

EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS

... ²This application discloses a process for the preparation of himbacine analogs ²useful as thrombin receptor antagonists. The process is based in part on the ²use of ²a base-promoted dynamic epimerization of a chiral nitro center. The chemistry ²taught herein can be exemplified by the following.²(see above formula)² ...

EICOSATRYNOIC ACID ESTERS AND AMIDES AND THEIR USE IN PHARMACEUTICS AND COSMETICS

L'invention concerne de nouveaux esters et amides de l'acide eicosatriynoïque, répondant à la formule générale: (I) dans laquelle R est un groupement alcoxy inférieur en C1-C8 ou cycloalcoxy en C4-C6, substitué par un ou plusieurs groupements hydroxyles et/ou interrompu par un ou plusieurs hétéroatomes choisis parmi l'oxygène et le soufre, un groupement amino de structure dans laquelle R1 ou R2 ldentigues ou différents désignent un atome d'hydrogène, un radical alkyle inférieur en C1-C8 linéaire ou ramifie, éventuellement interrompu par un ou plusieurs hetéroatomes choisis parmi l'oxygène, le soufre et l'azote, ce radical alkyle pouvant être substitué par un ou plusieurs groupements hydroxyles, sous réserve que R1 et R2 ne peuvent désigner simultanément un atome d'hydrogène, ou bien R1 et R2 forment ensemble avec l'atome d'azote auquel ils sont liés un hétérocycle contenant éventuellement un hétéroatome supplémentaire choisi parmi l'oxygène, le soufre et l'azote, l'un des radicaux ...

REACTIVE PLASTICIZER ESTER PLASTIC BINDER FOR EXPLOSIVES.

L'invention concerne un plastifiant réactif énergétique pour un explosif à liant plastique (PBX), et précisément un plastifiant réactif énergétique pour PBX qui présente des performances élevées et une insensibilité sans fuite de plastifiant en étant lié par un liant polymère pour un explosif à liant plastique.

Process for the preparation of alkynoic acids and alkynoic acid esters via oxidation of alkynols

Dimer-selective RXR modulator compounds having agonist, partial agonist and/or antagonist activity in the context of an RXR homodimer and/or RXR heterodimers are provided. Also provided are pharmaceutical compositions incorporating such dimer-selective RXR modulator compounds and methods for their therapeutic use.

Eicosatriynoic esters and amides and their use in pharmacy and cosmetics

Processes for preparing 5,8,11-eicosatriynoic acid as well as esters and amides thereof involves initially preparing the acid by reacting 1-decyne with 1,4-dihalo-2-butyne in the presence of a strong base to form 1-halo-2,5-tetradecadiyne which is then reacted with 5-hexynoic acid so as to form 5,8,11-eicosatriynoic acid. This acid can then be converted to the acid chloride form and reacted with an alcohol to form an ester or converted to a potassium salt and reacted with a halide also to form an ester, or after conversion to an acid chloride reacted with an amine in the presence of a tertiary amine to form an amide, or the acid can be reacted with carbonyldiimidazole in the presence of a solvent and excess amine to form an amide.

АГЕНТЫ, МЕЧЕННЫЕ ПАРАВОДОРОДОМ, И ИХ ПРИМЕНЕНИЕ ДЛЯ МАГНИТНОЙ РЕЗОНАНСНОЙ ВИЗУАЛИЗАЦИИ

Изобретение относится к медицине, а именно к способу магнитного резонансного исследования биологического образца. Сущность изобретения состоит в следующих действиях: а) взаимодействие водорода, обогащенного параводородом, с гидрогенизуемым предшественником агента МР визуализации, содержащим ядро с ядерным спином, не равным нулю, и отличное от1Н для получения гидрированного агента МР визуализации, б) введение указанного гидрированного агента МР визуализации в указанный образец, в) облучение указанного образца излучением с частотой, выбранной таким образом, чтобы возбуждать переходы ядерных спинов указанного ядра с ядерным спином, не равным нулю, в указанном гидрированном агенте МР визуализации, г) детектирование сигналов магнитного резонанса указанного ядра с ядерным спином, не равным нулю, из указанного образца, и д) возможно, генерирование изображения или биологических функциональных данных или динамического потока данных из указанных детектированных сигналов. Технический результат - расширение ...

Способ получения ди-с @ -с @ -алкиловых эфиров ацетилендикарбоновой кислоты

Способ получения замещенных ненасыщенных алифатических эфиров

Herstellung von Cis-Olefinen

ETHYNYLPHENYL ENTHALTENDE RETINSAEURE-DERIVATE.

Method of preparing 1,1-disubstituted diunsaturated compounds and polymers and novel products thereof

Compounds CH2 = CR1 . CR2 = CXY or CH­C.CR2=CXY and homopolymers thereof, wherein R1 is hydrogen,halogen, phenyl or C1- 5 alkyl, R2 is hydrogen or methyl, X and Y are CN, COOEt, SO2Et, SO2Ph, CHO, COCH3, COPh, PO(OEt)2, or CONH2 or X may also be phenyl, are prepared by reacting CH2 = CR1COR2 or CH­C.COR2 with XCH2 in the presence of at least one metal salt having a cation which is Zn, Cu, Mn, Cr, Co, Ni, Ca, Mg or Li and an anion which is Cl, Br, I, No3 or C1- 18 carboxylate; when X is phenyl, R1 and R2 are hydrogen and the salt is a carboxylate. Solvents, mineral acids, antioxidants and drying agents may be present. Novel compounds.-Compounds as above in which X and Y are dissimilar are claimed as novel. The Diels-Alder adduct of 1-cyano-1-carbethoxy butadiene-1,3 with anthracene is referred to The products of the invention are of use in adhesives and coatings.ALSO:Homopolymers of compounds of the formula CH2 = CR1.CR2 = CXY or CH = C.CR2 = CXY where R1 is hydrogen, halogen, phenyl or ...

Production of acetylenic esters

Acetylenic esters are produced by reacting an acetylenic compound of the formula R-C IDENTICAL C-H, wherein R is a hydrogen atom or an unsubstituted or substituted alkyl, aryl, aralkyl or alkaryl radical, with a dialkyl carbonate CO(OR<1>)2 in the presence of a strong base, to produce the desired acetylenic ester R-C IDENTICAL C-COOR<1> and an alcohol R<1>OH, the latter being removed as it is formed.

PROCEDURE FOR CARBOXYLIERUNG OF TERMINAL ALKINES

PARA HYDROGEN MARKED MEANS AND THEIR USE FOR IMAGING BY NON--PROTON MAGNETIC RESONANCE

Novel cyclopentenedione antifungal compounds and methods for their use

Hydroxy and ether-containing oxyalkylene esters and uses thereof

EICOSATRYNOIC ACID ESTERS AND AMIDES AND THEIR USE IN PHARMACEUTICS AND COSMETICS

METHOD FOR THE SYNTHESIS OF DHA

A method for preparing docosahexaenoic acid (DHA). The method comprises coupling a compound represented by Formula I with a compound represented by Formula II followed by partial hydrogenation to obtain a compound represented by Formula III. The compound represented by Formula III acts as a DHA precursor and thus can be hydrolysed to obtain DHA. Novel starting materials represented by Formula I and Formula II, and synthetic routes for preparing the same are also provided.

A α - acyloxy ketone compound preparation method

PROPIOLIC ACID ESTERS AS INDUSTRIAL MICROBICIDES

PROCESS FOR PREPARINT FARNESYL ACETIC ESTERS AND 2-SUBSTITUTED PRODUCTS THEREOF

PROSTACYCLIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE

Querverbrückte Cyclohexan-Derivate und flüssigkristallines Medium

VERWENDUNG EINES KRISTALLINE VERBINDUNGEN MIT MEHREREN ACETYLENISCHEN BINDUNGEN ENTHALTENDEN AUFZEICHNUNGSMATERIALS ZUR HERSTELLUNG MIKROSKOPISCHER ODER ELEKTRONENMIKROSKOPISCHER BILDER UND VERFAHREN ZUR HERSTELLUNG DERARTIGER BILDER

ETHYNYLPHENYL CONTAINING RETINSAEURE DERIVATIVES.

INDUSTRIAL MICROBICIDE

Cycloheptadiene germinal diketone derivative and preparation method thereof

METHOD OF PREPARATION Of ACETYLENIC ESTERS

PROCEDE DE PREPARATION D'ESTERS ACETYLENIQUES. ON PREPARE CES ESTERS ACETYLENIQUES EN FAISANT REAGIR UN COMPOSE ACETYLENIQUE DU TYPE RC CH DANS LEQUEL R EST DE L'HYDROGENE, UN RADICAL ALKYLE, ARYLE OU ARALKYLE AVEC UN CARBONATE DIALKYLIQUE EN PRESENCE D'UNE BASE FORTE. UTILISATION DE CE PROCEDE POUR N'OBTENIR QUE DES ESTERS ACETYLENIQUES.

PROCESS FOR PREPARINT FARNESYL ACETIC ESTERS AND 2-SUBSTITUTED PRODUCTS THEREOF

METHOD FOR THE SYNTHESIS OF DHA

A method for preparing docosahexaenoic acid (DHA). The method comprises coupling a compound represented by Formula I with a compound represented by Formula II followed by partial hydrogenation to obtain a compound represented by Formula III. The compound represented by Formula III acts as a DHA precursor and thus can be hydrolysed to obtain DHA. Novel starting materials represented by Formula I and Formula II, and synthetic routes for preparing the same are also provided.

Eicosatriynoic acid esters and their application in pharmaceutical and cosmetic practice

Compound, corresponding to the formula C8 H17 (C≡C--CH2)3 CH2 CH2 COR (I) in which R is a C1 -C8 lower alkoxy or C4 -C6 cycloaly group, substituted with one or more hydroxyl groups and/or interrupted by one or more hetero atoms chosen from oxygen and sulphur, an amino group of structure см. иллюстрацию в PDF-документе in which R1 or R2, which may be identical or different, denote a hydrogen atom or a linear or branched C1 -C8 lower alkyl radical, optionally interrupted by one or more hetero atoms chosen from oxygen, sulphur and nitrogen, this alkyl radical being able to be substituted with one or more hydroxyl groups, R1 and R2 not being able to denote hydrogen simultaneously, or alternatively R1 and R2 form, together with the nitrogen atom, a heterocyclic system optionally containing oxygen, sulphur or nitrogen as an additional hetero atom, one of the radicals R1 and R2 also being able to denote, when the other is a hydrogen atom, an aryl radical of formula (II): см. иллюстрацию в PDF-документе ...

PHOTOSENSITIVE CRYSTALLINE POLYACETYLENIC SYSTEM AND METHOD OF EXPOSURE

Novel Crosslinking Agent Compound and Superabsorbent Polymer Prepared by Using the Same

Provided are a novel crosslinking agent compound, and a superabsorbent polymer prepared by using the same. More particularly, provided are a crosslinking agent compound having a novel structure, which exhibits excellent crosslinking property and thermal degradability, and a superabsorbent polymer prepared by using the same.

COSMETIC COMPOSITIONS CONTAINING ESTER OBTAINED FROM 2-BUTYL-1-OCTANOL

Ethynylphenyl-containing retinoic acid derivatives

Retinoid-like activity is exhibited by compounds of the formula where n is 0-5 and A is H, lower alkyl, or -COOH or ester or amide thereof, -CH2OH or an ether or ester derivative, or -CHO or an acetal derivative, or a pharmaceutically acceptable salt.

非水電解液、それを用いた電気化学素子、及びそれに用いられるアルキニル化合物

Verfahren zur Herstellung von acetylenisch ungesättigten Verbindungen

Verfahren zur Herstellung von olefinisch ungesaettigten Verbindungen

PTODUCTION OF ACETYLENIC ESTERS

Para-hydrogen labelled agents and their use in magnetic resonance imaging

PREPARATION OF ISOXAZOLE-4,5-DICARBOXYLIC DIESTERS

A process for preparing novel isoxazole-4,5-dicarboxylic diesters of the formula I (see formula I) where R1 is an aliphatic radical of 1 to 20, cycloaliphatic radical of 3 to 10, aromatic radical of 6 to 10, heteroaromatic or heterocyclic radical of 3 to 10 or araliphatic radical of 4 to 12 carbon atoms, each radical being unsubstituted or substituted by substituents which are inert under the reaction conditions, and where R2 and R3 are each alkyl, comprises reacting an aldoxime of the formula II (see formula II) with an acetylenedicarboxylic diester of the formula III R2OOC-C~C-COOR3 (III) in solution, in the presence of an aqueous solution of a hypohalite in the pH range from 5 to 10.

HYDROXY AND ETHER-CONTAINING OXYALKYLENE ESTERS AND USES THEREOF

This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating blood disorders such as anemias, immunomodulation, enhancing recombinant gene expression, treating insulin-dependent patients, treating cystic fibrosis patients, inhibiting telomerase activity, treating virus-associated tumors, especially EBV-associated tumors, augmenting expression of tumor suppressor genes, inducing tolerance to antigens, or treating, preventing or ameliorating protozoan infection or inhibiting histone deacetylase in cells. The compositions of the invention are to and the methods of the invention use hydroxy and ether-containing oxyalkylene esters.

7-SUBSTITUTED DERIVATIVES OF 3,5-DIHYDROXYHEPT-6-YNOIC ACID, A PROCESS FOR THE PREPARATION THEREOF, THE USE THEREOF AS PHARMACEUTICALS, AND INTERMEDIATES

... 7-Substituted derivatives of 3,5-dihydroxyhept-6-ynoic acid, a process for the preparation thereof, the use thereof as pharmaceuticals, and intermediates 7-Substituted 3,5-dihydroxyhept-6-ynoic acids and the derivatives thereof of the formula I (see fig. I) as well as the corresponding lactones of the formula II (see fig. II) in which R denotes a) a radical of the formula a (see fig. III) in which R1 and R2 are, independently of one another, a straight-chain or branched alkyl or alkenyl radical having up to 6 carbon atoms, a saturated or up to doubly unsaturated cyclic hydrocarbon radical having 3-6 carbon atoms or phenyl radical which is optionally substituted by 1-3 identical or different radicals selected from the group comprising straight-chain or branched alkyl having up to 4 carbon atoms, halogen, alkoxy having up to 4 carbon atoms and hydroxyl, and X=Y-Z is a group of the formula CR3=CR4-CR5, N=CR4-CR5, N=N-CR5, N=CR4-N, in which R3, R4, R5 are, independently of one another, hydrogen ...

UNSATURATED ETHERS AND THIOETHERS

HYDROXY AND ETHER-CONTAINING OXYALKYLENE ESTERS AND USES THEREOF

This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating blood disorders such as anemias, immunomodulation, enhancing recombinant gene expression, treating insulin-dependent patients, treating cystic fibrosis patients, inhibiting telomerase activity, treating virus-associated tumors, especially EBV-associated tumors, augmenting expression of tumor suppressor genes, inducing tolerance to antigens, or treating, preventing or ameliorating protozoan infection or inhibiting histone deacetylase in cells. The compositions of the invention are to and the methods of the invention use hydroxy and ether-containing oxyalkylene esters.

HYDROXY FATTY ACID COMPOUNDS AND USES THEREOF FOR DISEASE TREATMENT AND DIAGNOSIS

PRODUCTION OF OPTICALLY ACTIVE CYCLOPENTENONES

PURPOSE: To provide an industrially advantageous method for producing optically active cyclopentenones extremely useful as a medicine, especially an intermediate for prostaglandins. CONSTITUTION: Cyclopentenone esters [2] can asymmetrically be hydrolyzed with an esterase having the ability to preferentially hydrolyze only either of optical isomers of the aforementioned cyclopentenone esters to produce the objective optically active cyclopentenones [1]. COPYRIGHT: (C)1992,JPO&Japio ...

PROPIONATE ESTER COMPOUND AND ACARICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT

PURPOSE: To obtain a propionate ester compound suitable as an acaricide especially for indoor Pyroplyphidae. CONSTITUTION: A compound of formula I (R1 is H, a halogen, a 1-4C alkyl, a 1-4C alkoxy; Y is CH2CH2CH2, OCH2, CH2O; Z is a 2-6C alkylene which may be substituted with a 1-4C alkyl; (m) is 1-5), e.g. 7-phenylheptyl propionate. This compound is obtained e.g. by reacting an alcohol of formula II with propionyl chloride in the presence of a base. The compound is excellent in a fast-acting property, a residual activity and a smoking effect in relation to the potency of an acaricide, and does not have such a small as causing troubles. COPYRIGHT: (C)1995,JPO ...

OPTICALLY ACTIVE ACETYLENE COMPOUND, ACETYLENIC POLYMER AND METHOD FOR PRODUCING THE SAME

PROBLEM TO BE SOLVED: To provide an acetylenic polymer having both an optically active substituent and a conjugated substituent exhibiting light emitting properties and multifunctionality and to provide a method for producing the polymer. SOLUTION: The acetylenic polymer is a polymer obtained by polymerizing a specific optically active acetylene compound. The method for producing the acetylenic polymer comprises polymerizing the specific optically active acetylene compound in the presence of an organic metal complex represented by general formula (II) [MLmL'n]pXq. COPYRIGHT: (C)2006,JPO&NCIPI ...

СПОСОБ ПОЛУЧЕНИЯ ЭФИРОВ АЛКИНИЛКАРБОНОВЫХ КИСЛОТ

Изобретение относится к технологии органического синтеза, а именно к способу получения эфиров алкинилкарбоновых кислот, которые применяются в производстве медицинских препаратов, пестицидов и других веществ, проявляющих биологическую активность. Цель: повышение производительности при увеличении выхода целевого продукта и упрощение технологии и создание условий для организации непрерывного процесса и увеличения концентрации целевого продукта в контактном растворе. Это достигается изменением окислителя и состава каталитической системы. В качестве окислителя используют кислород, а в качестве соединений меди - ее монохлорид. Суть предлагаемого изобретения состоит во взаимодействии алкина РС СН с оксидом углерода, одноатомным спиртом, окислителем в присутствии каталитической системы, содержащей соединения палладия и меди.

7-OXOPROSTACYCLIN DERIVATIVES AND PROCESS FOR THE PREPARATIONTHEREOF

EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS

The application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following. (I) ...

METHOD FOR THE SYNTHESIS OF DHA

A method for preparing docosahexaenoic acid (DHA). The method comprises coupling a compound represented by Formula I with a compound represented by Formula II followed by partial hydrogenation to obtain a compound represented by Formula III. The compound represented by Formula III acts as a DHA precursor and thus can be hydrolysed to obtain DHA. Novel starting materials represented by Formula I and Formula II, and synthetic routes for preparing the same are also provided.

PREPARATION OF ISOXAZOLE-4,5-DICARBOXYLIC DIESTERS

A process for preparing novel isoxazole-4,5-dicarboxylic diesters of the formula I (see formula I) where R1 is an aliphatic radical of 1 to 20, cycloaliphatic radical of 3 to 10, aromatic radical of 6 to 10, heteroaromatic or heterocyclic radical of 3 to 10 or araliphatic radical of 4 to 12 carbon atoms, each radical being unsubstituted or substituted by substituents which are inert under the reaction conditions, and where R2 and R3 are each alkyl, comprises reacting an aldoxime of the formula II (see formula II) with an acetylenedicarboxylic diester of the formula III R2OOC-C~C-COOR3 (III) in solution, in the presence of an aqueous solution of a hypohalite in the pH range from 5 to 10.

ESTERS AND AMIDES OF ACID EICOSATRIYNOIQUE AND THEIR APPLICATION IN PHARMACY AND COSMETIC

UNSATURATED ETHERS AND THIOETHERS

UNSATURATED ETHERS AND THIOETHERS

... 1394864 Unsaturated ethers and thioethers SANDOZ Ltd 31 May 1972 [2 June 1971] 25476/72 Heading C2C Compounds of Formula I wherein R 1 is alkyl of 1 to 10 carbon atoms; alkenyl of 3 to 10 carbon atoms; alkynyl of 3 to 10 carbon atoms; cycloalkyl of 3 to 6 carbon atoms; cycloalkyl of 3 to 6 carbon atoms substituted by alkyl of 1 to 4 carbon atoms; cycloalkenyl of 5 to 7 carbon atoms; cycloalkenyl of 5 to 7 carbon atoms substituted by alkyl of 1 to 4 carbon atoms; cycloalkyl (of 3 to 6 carbon atoms) alkyl (of 1 to 4 carbon atoms); cycloalkyl (of 3 to 6 carbon atoms) alkyl (of 1 to 4 carbon atoms) ring substituted by alkyl of 1 to 4 carbon atoms; cycloalkenyl (of 5 to 7 carbon atoms) alkyl (of 1 to 4 carbon atoms); or cycloalkenyl (of 5 to 7 carbon atoms) alkyl (of 1 to 4 carbon atoms) ring substituted by alkyl of 1 to 4 carbon atoms; R 2 and R 3 , which are the same or different, are each hydrogen or alkyl of 1 to 4 carbon atoms, Y is cyano; -CONR 4 R 5 wherein R 4 and R 5 , which are the ...

HYDROXY FATTY ACID COMPOUNDS AND USES THEREOF FOR DISEASE TREATMENT AND DIAGNOSIS

A compound of formula (I): wherein R represents a hydroxy substituted C24 - C40 straight chain aliphatic group containing at least one double bond in the carbon chain; and at least one carbon in the chain is substituted with a hydroxy group. Such compounds are useful for detecting inflammation, inflammatory disorders and cancer in a subject, and can also be used in therapeutic applications including treatment and/or prevention of these conditions. Pharmaceutical compositions, combinations and supplements, as well as methods of treatment using the described compounds are therefore also described.

7-OXOPROSTACYCLIN DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

Prostacyclin, although having a useful dilating effect on blood vessels, is not sufficiently stable to ensure successful use as a hypotensive agent. A 7-oxopro-stacyclin derivative of the general formula in which R3 represents a hydrogen atom, a straight-chain or branched-chain alkyl radical having from 1 to 4 carbon atoms, or a C1-C4-alkoxyalkyl radical, W represents a group, the hydroxy group of which may be free or substituted by a C1-C4-alkanoyl group or a tetrahydropyranyl group and may be in the ?- or .beta.-position, R2 represents a straight-chain or branched-chain halogen-substituted alkyl group having from 3 to 7 carbon atoms, a straight-chain or branched-chain alkenyl radical having from 3 to 7 carbon atoms which can be substituted by fluoro, chloro or a C1-C4-alkyl group, or a straight-chain or branched-chain alkynyl radical having from 2 to 6 carbon atoms which may be substituted in the 1position by fluorine or C1-C4-alkyl, and R5 represents a hydroxy group or a ...

photosensitive and proceeded element of formation of image by means of this element

PROPIOLIC ACID ESTERS AS INDUSTRIAL MICROBICIDES

METHOD FOR PRODUCING ACETYLENE CARBOXYLIC ACID COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing an acetylene carboxylic acid compound by which acetylene carboxylic acid or an acetylene carboxylic acid compound as the derivative thereof can be obtained from acetylene alcohol at a high yield. SOLUTION: The method for producing an acetylene carboxylic acid compound comprises: an electrolytic oxidation stage where acetylene alcohol is subjected to electrolytic oxidation in an acid aqueous solution to produce acetylene carboxylic acid; an extraction stage where the acetylene carboxylic acid is extracted from the acid aqueous solution; and an esterification stage where the acetylene carboxylic acid extracted in the extraction stage is esterified. COPYRIGHT: (C)2005,JPO&NCIPI ...

Method of synthesizing alpha-ketol unsaturated fatty acid

Acetylenic esters and polymers obtained with these esters, like their method of preparation

ACID ESTERS AND AMIDES [...] AND THEIR APPLICATION IN PHARMACEUTICAL AND COSMETIC

An Organogel Formed by a Hetero-bifunctional Gelator in a Monomeric Solvent and Polymerization thereof, and Polymer Matrix Embedded Nanofibers obtained Therefrom

EICOSATRIYNOIC ACID ESTERS AND THEIR APPLICATION IN PHARMACEUTICAL AND COSMETIC PRACTICE

ENANTIOMERANGEREICHERTE MALONIC ACID MONOESTER ALPHAMONOSUBSTITUTED WITH TERTIARY HYDROCARBON GROUP OR ITS SALT AND ITS PRODUCTION

PROBLEM TO BE SOLVED: To obtain the subject enantiomerangereicherte compound substituted with a tertiary hydrocarbon group useful for a synthetic element in the field of medicine and agrochemical and a chiral auxiliary. SOLUTION: This compound is shown by formula I (R1, R3, R4 and R5 are each a hydrocarbon; any two of R3, R4 and R5 may form a carbon ring with a tertiary carbon atom to be replaced these groups; M is H, a metal equivalent or an ammonium ion which may be replaced) or its salt such as α-t-butylmalonic acid monoethyl ester. The compound of formula I is obtained by partially hydrolyzing an α-monosubstituted malonic acid diester of formula II (R2 is a hydrocarbon which maybe different from R1). The partial hydrolyzate is carried out by adding a solution or a suspension to bring about a hydroxyl ion of a basic substance, maintaining pH4-9, preferably using a water-soluble solvent at 15-50°C under 0.8-2 bar. Consequently, the compound of formula I is obtained from an inexpensive ...

7-OXOPROSTACYCLINDERIVATE UND VERFAHREN ZU IHRER HERSTELLUNG

Esters and polymers obtained therefrom

The invention comprises acetylenic esters of formula (ZC ­ C.COO)mR(OH)n where n is 0, 1, 2 or 3, m is 1, 2, 3 or 4, the sum of n plus m is 2, 3 or 4, R is the residue of a polyhydric alcohol, a polyhydric phenol or a phenolic alcohol and having the formula R(OH)(m + n) which residue contains only carbon and hydrogen or carbon, hydrogen and halogen atoms, the total number of carbon atoms therein being from 2 to 18, and Z is a hydrogen atom, an alkyl group of 1 to 5 carbon atoms or an aryl group having from 6 to 10 carbon atoms. The esters are prepared by reacting a polyhydric alcohol, polyhydric phenol or phenolic alcohol of formula R(OH)(m + n) with an acetylenic acid of formula ZC ­ C.COOH or with a halide or anhydride of such acid at a temperature below 120 DEG C. Esters where m and n are both one may be prepared by reacting an acetylenic acid with an alkylene oxide of formula where R1 and R11 are hydrogen atoms or alkyl groups of 1 to 5 carbon atoms. In examples ...

Process for the production of unsaturated compounds by dehydrohalogenation

Hydrogen halide is eliminated from a compound containing a halogen atom a or b to a carbonyl group, defined to include an aldehyde, ketone or carboxylic acid, ester or amide group, or to an ethylene, acetylene or cyano group by reaction, preferably in the presence of a solvent, between 0 DEG to 200 DEG C., with 1,5-diazobicyclo-[4,3,0] - non - 5 - ene, 1,4 - diazabicyclo - [3,3,0]-oct - 4 - ene, 1,5 - diazabicyclo - [4,5,0] - undec-5 - ene, 1,5 - diaza - 8 - methyl - [4,4,0] - dec-5-ene. The halogen may be chlorine, bromine or iodine. Between 1 to 3 gm. mols. of dehydrohalogenating agent per gram atom of halogen may be employed, an excess may be used as solvent. Specified solvents include hydrocarbons, ethers, acetonitrile, dimethyl formamide. The examples include the synthesis of Vitamin A acetate; 2,7 - dicadienyne - (9) - acid methyl ester - (1); trans, trans - 1 - phenylhexadiene - (1,3) - yne(5); trans - 1 - phenylbutene - (1) - yne (3); tridecene - (10) - yne (12) acid methyl ester ...

A PROCESS FOR THE MANUFACTURE OF UNSATURATED COMPOUNDS

... 1,206,440. Unsaturated esters and nitriles. ROCHE PRODUCTS Ltd. 12 Dec., 1968 [18 Dec., 1967], No. 57284/67. Heading C2C. Unsaturated compounds of the general formula wherein R1 and R3 each represent an alkyl group and R2 is an alkyl, alkenyl or alkynyl group which may be substituted by cycloalkyl, cycloalkenyl or aryl, an aryl group or a heterocyclic residue or R1 and R2 together represent a heterocyclic or carbocyclic residue and X is a CN, amino-carbonyl group which may be alkylsubstituted or an alkoxy-carbonyl group, which comprises reacting a carbonyl compound of the general formula with a phosphine oxide of general formula where Y, Y1 and Y2 are each halogen or an alkoxy group and the broken lines denote that the atoms or groups attached thereby are optional, in the presence of a base. Amongst the Examples (1) acetophenone was reacted with (ethoxycarbonyl - methyl) - bis - (2 - chlorophenoxy) phosphine oxide in the presence ...

INDUSTRIAL MICROBICIDAL COMPOSITIONS CONTAINING PROPIOLIC ACID ESTERS

... 1309053 Propiolic acid esters SUMITOMO CHEMICAL CO Ltd 19 April 1971 [15 April 1970] 26995/71 Heading C2C [Also in Division A5] The invention comprises propiolic acid esters having the general formula wherein R is a cyclohexyl group or a group of the formula -CH 2 -R1 where R1 is an aryl- C 1-4 -alkyl group, a saturated or unsaturated phthalimide group, or a group of the formula where X is a halogen atom, a nitro group, C 1 - C 4 alkyl group or C 1 -C 4 alkoxy group, and n is an integer from 1 to 5. They may be prepared by heating an alcohol of the formula R-OH with propiolic acid. The compounds of the invention may be used as active ingredients in microbicide compositions.

ETHYNYLPHENYL-CONTAINING RETINOIC ACID DERIVATIVES

Retinoid-like activity is exhibited by compounds of the formula where n is 0-5 and A is H, lower alkyl, or -COOH or ester or amide thereof, -CH2OH or an ether or ester derivative, or -CHO or an acetal derivative, or a pharmaceutically acceptable salt.

REACTIVE PLASTICIZER ESTER FOR EXPLOSIVES HAS PLASTIC BINDER.

An Organogel Formed by a Hetero-bifunctional Gelator in a Monomeric Solvent and Polymerization thereof, and Polymer Matrix Embedded Nanofibers obtained Therefrom

PURPOSE: An organogel is provided to ensure thermoreverible property and viscoelasticity and to have specific structure that nanofiber formed by self-assembly of gelation materials is uniformly dispersed in a gel state. CONSTITUTION: An organogel compound has a structure represented by the following chemical formula (I). A method for manufacturing an organic gel compound comprises a step of reacting 4-hydroxy-4'-[6-(acryloyloxy)hexyloxy]biphenyl and a compound of the following chemical formula (II). In chemical formula (II), n is an integer of 9-13. A method for manufacturing a polymer composite inserted with nanofiber comprises a step of irradiating ultraviolet rays to the organogel formed with hexyl methacrylate and the compound of chemical formula (I) in the presence of a photoinitiator. © KIPO 2009 ...

HYDROXY FATTY ACID COMPOUNDS AND USES THEREOF FOR DISEASE TREATMENT AND DIAGNOSIS

A compound of formula (I): wherein R represents a hydroxy substituted C24 - C40 straight chain aliphatic group containing at least one double bond in the carbon chain; and at least one carbon in the chain is substituted with a hydroxy group. Such compounds are useful for detecting inflammation, inflammatory disorders and cancer in a subject, and can also be used in therapeutic applications including treatment and/or prevention of these conditions. Pharmaceutical compositions, combinations and supplements, as well as methods of treatment using the described compounds are therefore also described.

Process for preparing methyl 4-oxo-5-tetradecynoate

A process for preparing methyl 4-oxo-5-tetradecynoate useful as an intermediate for synthesizing (R,Z)-5-dec-1-enyl-oxacyclopentan-2-one, which comprises reacting monomethyl succinate with an alkyl chlorocarbonate in the presence of a base to form an acid anhydride and reacting the acid anhydride with a Grignard reagent of 1-decyne. Methyl 4-oxo-5-tetradecynoate can be prepared in high yields at high purities by this process.

Patent JPS5024622B1

Esters

Procedimento per la preparazione di esteri acetilenici

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Werkwijze voor de bereiding van acetyleenesters.

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