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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 3913. Отображено 100.
13-12-2012 дата публикации

Metal complex, and adsorbent, occlusion material and separator material made from same

Номер: US20120312164A1
Автор: Chikako Ikeda, Koichi Kanehira, Yasutaka Inubushi
Принадлежит: Kuraray Co Ltd

This invention provides a metal complex having a gas adsorption capability, a gas storing capability, and a gas separation capability. The present invention attained the above object by a metal complex comprising: a dicarboxylic acid compound (I) represented by the following General Formula (I), wherein R 1 , R 2 , R 3 , and R 4 are as defined in the specification; at least one metal ion selected from ions of a metal belonging to Group 2 and Groups 7 to 12 of the periodic table; and an organic ligand capable of bidentate binding to the metal ion, the organic ligand belonging to the D ∞h point group, having a longitudinal length of not less than 8.0 Å and less than 16.0 Å, and having 2 to 7 heteroatoms.

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Номер записи: 1
14-03-2013 дата публикации

Novel amides as fungicides

Номер: US20130065922A1
Автор: Clemens Lamberth, Fiona Murphy Kessabi, Guillaume Berthon, Laura Quaranta, Renaud Beaudegnies, Stephan Trah
Принадлежит: SYNGENTA CROP PROTECTION LLC

Compounds of the general formula (I), wherein the substituents are as defined in claim 1 , are useful as fungicides.

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Номер записи: 2
02-05-2013 дата публикации

ANTIMICROBIAL AGENTS

Номер: US20130109713A1
Автор: LaVoie Edmond J., Parhi Ajit, Pilch Daniel S.
Принадлежит:

The invention provides a compound of formula I:or a salt thereof, wherein R-Rand X and Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents. 2. The compound of wherein:{'sup': 1', 'y', 'y, 'sub': 1', '6, 'Ris Ror (C-C)alkyl that is substituted with one or more R;'}{'sup': 2', 'z', 'x, 'sub': 1', '6, 'Ris Ror (C-C)alkyl that is substituted with one or more R;'}{'sup': 4', '5', '6', '7', 'd', '4', '5', '6', '7', 'p', 'p', 'p', 'g', 'h', 'g', 'h', 'a', '4', '5', '6', '7', 'b, 'sub': 1', '6', '3', '6', '1', '6', '1', '6', '1', '6', '1', '6', '2', '3', '2', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6, 'at least one of RRRand Ris aryl or heteroaryl wherein each aryl or heteroaryl is optionally substituted with one or more (e.g. 1, 2, 3, or 4) R; and the remainder of RRRand Rare each independently H, halo, cyano, nitro, hydroxy, carboxy, trifluoromethyl, trifluoromethoxy, (C-C)alkyl, (C-C)cycloalkyl, (C-C)alkoxy, (C-C)alkoxycarbonyl, (C-C)alkanoyloxy, aryl, heteroaryl, aryloxy, heteroaryloxy, (C-C)alkylthio, —S(O)R, —S(O)R, —S(O)R, —S(O)NRR, and —NRR; wherein any alkyl and any alkyl or alkanoyl portion of any aryl(C-C)alkyl, heteroaryl(C-C)alkyl, aryl(C-C)alkanoyl or heteroaryl(C-C)alkanoyl is optionally substituted with one or more (e.g. 1, 2, 3, or 4) R; and wherein any aryl, heteroaryl, or any aryl or heteroaryl portion of any aryl(C-C)alkyl, heteroaryl(C-C)alkyl, aryl(C-C)alkanoyl or heteroaryl(C-C)alkanoyl of RRRand Ris optionally substituted with one or more (e.g. 1, 2, 3, or 4) R;'}{'sup': 8', 'p', 'p', 'p', 'g', 'h', 'g', 'h', '8', 'a', '8', 'b, 'sub': 1', '6', '3', '6', '1', '6', '1', '6', '1', '6', '1', '6', '2', '3', '2, 'Ris H, halo, cyano, nitro, hydroxy, carboxy, trifluoromethyl, trifluoromethoxy, (C-C)alkyl, (C-C)cycloalkyl, (C-C)alkoxy, (C-C)alkoxycarbonyl, (C-C)alkanoyloxy, aryl, heteroaryl, aryloxy, ...

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Номер записи: 3
16-05-2013 дата публикации

SUBSTITUTED ENAMINOCARBONYL COMPOUNDS

Номер: US20130123506A1
Автор: ARNOLD Christian, Beck Michael Edmund, Goergens Ulrich, JESCHKE Peter, MALSAM Olga, Mueller Thomas, Nauen Ralf, PITTA Leonardo, Pontzen Rolf, Reckmann Udo, Sanwald Erich, Schallner Otto, Schenke Thomas, Velten Robert
Принадлежит: Bayer CropScience AG

The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects. 1. A compound of formula (III){'br': None, 'sup': '1', 'sub': '2', 'HN(R)—CH-A\u2003\u2003(III)'}in whichA represents pyrid-3-yl that is optionally substituted in the 6-position by fluorine, chlorine, bromine or trifluoromethyl, or represents 1,3-thiazol-5-yl that is optionally substituted in the 2-position by chlorine; and{'sup': 1', '1, 'sub': 1', '3', '2', '3, 'Rhalo-C-C-alkyl or halo-C-C-alkenyl, with the proviso that Rmust be 2,2-difluoroethyl when A represents pyrid-3-yl that is substituted in the 6-position by chlorine.'}2. A compound of formula (III) according to claim 1 , in whichA represents 6-fluoropyrid-3-yl, 6-chloropyrid-3-yl, 6-bromopyrid-3-yl, 6-trifluoromethylpyrid-3-yl, 2-chloro-1,3-thiazol-5-yl; and{'sup': 1', '1, 'sub': 1', '3', '2', '3, 'Rrepresents fluorine-substituted C-C-alkyl or C-C-alkenyl, with the proviso that Rmust be 2,2-difluoroethyl when A represents 6-chloropyrid-3-yl.'}3. A compound which is N-[(6-chloropyridin-3-yl)methyl]-2 claim 1 ,2-difluoroethane-1-amine. This application is a continuation application of U.S. application Ser. No. 13/334,949, filed Dec. 22, 2011, which is a continuation application of U.S. application Ser. No. 12/295,355, filed Mar. 11, 2009, now U.S. Pat. No. 8,106,211, issued Jan. 31, 2012, which is a §371 National Stage Application of PCT/EP2007/002386 filed Mar. 19, 2007 which claims priority from German Application 10 2006 015 467.3 filed Mar. 31, 2006, the contents of each of these are hereby incorporated by reference in their entireties.1. Field of the InventionThe present application relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.2. Description of Related ...

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Номер записи: 4
29-08-2013 дата публикации

Fluoroalkylation Methods And Reagents

Номер: US20130225815A1
Автор: Hiroyuki Morimoto, John F. Hartwig, Patrick Fier
Принадлежит: University of Illinois

A method of forming a fluorinated molecular entity includes reacting in a reaction mixture an aromatic halide, copper, a fluoroalkyl group, and a ligand. The aromatic halide includes an aromatic group and a halogen substituent bonded to the aromatic group. The ligand includes at least one group-V donor selected from phosphorus and an amine. The overall molar ratio of copper to aromatic halide in the reaction mixture is from 0.2 to 3. The method further includes forming a fluoroalkylarene including the aromatic group and the fluoroalkyl group bonded to the aromatic group. A composition, which may be used in the method, consists essentially of copper, the fluoroalkyl group, and the ligand, where the molar ratio of copper to the fluoroalkyl group is approximately 1.

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Номер записи: 5
03-10-2013 дата публикации

METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES

Номер: US20130261310A1
Автор: BLAND DOUGLAS C., DAVIS CLARK S., FUNG ALEXANDER P., JR. Ronald, RENGA JAMES, Ross, Roth Gary A.
Принадлежит:

3-substituted-6-trifluoromethyl pyridines are useful synthetic intermediates in the preparation of the N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines, which are useful in forming potent insecticides. Methods of forming such 3-substituted-6-trifluoromethyl pyridines are disclosed. Also disclosed are methods of using 6-trichloromethyl halogenated pyridines to form 3-substituted-6-trifluoromethyl pyridines are disclosed. 1. A method of forming a 3-substituted-6-trifluoromethyl pyridine , the method comprising reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6-trifluoromethyl halogenated pyridine.2. The method of claim 1 , wherein reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6-trifluoromethyl halogenated pyridine comprises reacting a 6-trichloromethyl-2 claim 1 ,3-dihalo pyridine with a fluorinating agent to form a 6-trifluoromethyl-2 claim 1 ,3-dihalo pyridine.3. The method of claim 1 , wherein reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6-trifluoromethyl halogenated pyridine comprises reacting a 2 claim 1 ,3-dichloro-6-trichloromethyl pyridine with a fluorinating agent to form a 2 claim 1 ,3-dichloro-6-trifluoromethyl pyridine.4. The method of claim 1 , wherein reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6-trifluoromethyl halogenated pyridine comprises reacting a 6-trichloromethyl halogenated pyridine with antimony pentafluoride to form a 6-trifluoromethyl halogenated pyridine.5. The method of claim 1 , wherein reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6-trifluoromethyl halogenated pyridine comprises reacting a 6-trichloromethyl halogenated pyridine with hydrogen fluoride to form a 6-trifluoromethyl halogenated pyridine.6. The method of claim 1 , wherein reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6- ...

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Номер записи: 6
14-11-2013 дата публикации

PROCESS FOR PRODUCTION OF AROMATIC ALCOHOL OR HETEROCYCLIC AROMATIC ALCOHOL

Номер: US20130303775A1
Автор: ABE Takafumi, Fushimi Norio, Kanbara Yutaka
Принадлежит: MITSUBISHI GAS CHEMICAL COMPANY, INC.

A process of production of an aromatic alcohol or a heterocyclic aromatic alcohol, containing a step of reacting an aromatic amine or a heterocyclic aromatic amine having an aromatic ring or a heterocyclic aromatic ring having thereon at least one substituent —CHRNRR(wherein R, Rand Reach independently represent hydrogen, an alkyl group having from 1 to 4 carbon atoms, or a benzyl group), with an alcohol, in the presence of a basic catalyst. 1. A process for producing an aromatic alcohol or a heterocyclic aromatic alcohol , the process comprising reacting an aromatic amine or a heterocyclic aromatic amine , comprising at least one substituent —CHRNRR , with an alcohol , in the presence of a basic catalyst ,{'sup': 1', '2', '3, 'wherein R, Rand Reach independently represent hydrogen, an alkyl group having from 1 to 4 carbon atoms, or a benzyl group.'}4. The process of claim 1 , wherein the basic catalyst is at least one selected from the group consisting of metallic sodium claim 1 , metallic potassium claim 1 , a sodium compound and a potassium compound.5. The process of claim 1 , wherein the alcohol is an alcohol having a linear or branched alkyl group having from 1 to 11 carbon atoms claim 1 , a cycloalkyl group having from 3 to 8 carbon atoms claim 1 , or an alkyl group having from 1 to 3 carbon atoms having a phenyl group substituted thereon claim 1 , having a hydroxyl group bonded thereto.6. The process of claim 1 , wherein water is added to the reaction.7. The process of claim 1 , wherein ammonia is added to the reaction.8. The process of claim 2 , wherein the basic catalyst is at least one selected from the group consisting of metallic sodium claim 2 , metallic potassium claim 2 , a sodium compound and a potassium compound.9. The process of claim 2 , wherein the alcohol is an alcohol having a linear or branched alkyl group having from 1 to 11 carbon atoms claim 2 , a cycloalkyl group having from 3 to 8 carbon atoms claim 2 , or an alkyl group having from 1 to ...

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Номер записи: 7
09-01-2014 дата публикации

New palladium catalyst, method for its preparation and its use

Номер: US20140012004A1
Автор: Gábor Vlád, Géza Timári, Tibor SOÓS, Zoltán DALICZEK, Zoltán Finta
Принадлежит: H4SEP KFT

The invention relates to palladium(0) tris{tri-[3,5-bis(trifluoromethyl)-phenyl]-phosphine} complex of formula (I), as well as to its preparation and use. This compound is outstandingly stable, and can be used as catalyst with excellent results.

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Номер записи: 8
27-02-2014 дата публикации

New Cyclopentadienyl, Indenyl or Fluorenyl Substituted Phosphine Compounds and Their Use in Catalytic Reactions

Номер: US20140058101A1
Автор: Almena Juan, Fleckenstein Christoph, Kadyrov Renat, Monsees Axel, Plenio Herbert, Riermeier Thomas
Принадлежит: EVONIK DEGUSSA GmbH

The invention is directed to a phosphine compound represented by general formula (1) wherein R′ and R″ independently are selected from alkyl, cycloalkyl and 2-furyl radicals, or R′ and R″ are joined together to form with the phosphorous atom a carbon-phosphorous monocycle comprising at least 3 carbon atoms or a carbon-phosphorous bicycle; the alkyl radicals, cycloalkyl radicals, and carbon-phosphorous monocycle being unsubstituted or substituted by at least one radical selected from the group of alkyl, cycloalkyl, aryl, alkoxy, and aryloxy radicals; Cpis a partially substituted or completely substituted cyclopentadien-1-yl group, including substitutions resulting in a fused ring system, and wherein a substitution at the 1-position of the cyclopentadien-1-yl group is mandatory when the cyclopentadien-1-yl group is not part of a fused ring system or is part of an indenyl group. Also claimed is the use of these phosphines as ligands in catalytic reactions and the preparation of these phosphines. 160-. (canceled)62. The method according to claim 61 , wherein the phosphine compound or the phosphonium salt is used in combination with the transition metal as a coordination compound.63. The method according to claim 61 , wherein the preparation of the organic compound includes the formation of a C—C bond or C-heteroatom bond.64. The method according to claim 61 , wherein the transition metal is Pd and the preparation of the organic compound includes the formation of a C—C bond and a reaction selected from the group consisting of:Suzuki cross-coupling of organoboron compounds with aryl, heteroaryl or vinyl halides or pseudohalides;Stille cross-coupling of organotin compounds with carbon electrophiles comprising a halogen or pseudohalogen as leaving group;Hiyama cross-coupling of organosilanes with aryl, heteroaryl or vinyl halides or pseudohalides;Negishi cross-coupling of organozinc compounds with aryl, heteroaryl or vinyl halides or pseudohalides;Kumada cross-coupling of ...

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Номер записи: 9
06-01-2022 дата публикации

METHOD FOR PRODUCING TRIARYLORGANOBORATES

Номер: US20220002321A1
Автор: Berneth Horst, Bruder Friedrich-Karl, Hönel Dennis, Kintrup Jürgen, Rölle Thomas
Принадлежит:

The invention relates to a process for preparing triaryl organoborates proceeding from organoboronic esters in the presence of an n-valent cation 1/n K, comprising the anhydrous workup of the reaction mixture and the use of the triaryl organoborates obtained as co-initiator in photopolymer formulations, holographic media and holograms. 1. Process for preparing triaryl organoborates of the formula 1/n KRB—R(IV) , where one equivalent of organoboronic ester of the formula B—R(OR)(OR) (I) is initially charged together with 1/n equivalents of salt K nX (II) and 3 equivalents of metal M in a solvent or a solvent mixture S1 , 3 equivalents of a haloaromatic R—Y (III) are added , an auxiliary L and optionally a second organic solvent or solvent mixture S2 is added and the compound 1/n K RB—R(IV) is separated off with the organic phase and{'sup': '1', 'sub': 1', '22', '3', '22', '3', '22', '5', '7', '7', '13, 'Ris an optionally hydroxyl- and/or alkoxy- and/or acyloxy- and/or halogen-substituted C- to C-alkyl, C- to C-alkenyl, C- to C-alkynyl, C- to C-cycloalkyl or C- to C-aralkyl radical,'}{'sup': 2', '3', '2', '3, 'sub': 1', '22', '3', '7, 'Rand Rare independently an optionally branched C- to C-alkyl radical or an optionally alkyl-substituted C- to C-cycloalkyl radical or Rand Rtogether form a 2-8-membered carbon bridge which is optionally substituted by alkyl and/or interrupted by oxygen atoms,'}{'sup': '4', 'sub': 6', '10', '1', '4', '1', '4, 'Ris a C- to C-aryl radical optionally substituted by at least one radical selected from halogen, C- to C-alkyl, trifluoromethyl, C- to C-alkoxy, trifluoromethoxy, phenyl and phenoxy,'}K is an organocation of valency n and having any substitution, based on nitrogen, phosphorus, oxygen, sulfur and/or iodine, and{'sup': 2', '3, 'L is an auxiliary that forms a complex of sparing solubility in S1 and/or S2 with M salts MY(OR), MY(OR) and MXY, where L is a Lewis-basic compound, especially selected from the group consisting of open chain ...

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Номер записи: 10
04-01-2018 дата публикации

BIPYRIDINE DERIVATIVES AND THEIR USES FOR ORGANIC LIGHT EMITTING DIODES

Номер: US20180002287A1
Автор: Chae Hyun Sik, Cho Jeong-Ju, CHOI Younsuk, JEON Soonok, KIM In Koo, KIM Kyungdoc, KIM SUNGHAN, KIM Tae-Rae, LEE Sae Youn, MIYAZAKI Hiroshi, NAM Youngmin, Numata Masaki, Oh Won Seok, SON Won-Joon
Принадлежит:

A condensed cyclic compound represented by Formula 1: 2. The condensed cyclic compound of claim 1 , wherein claim 1 , in Formula 2 claim 1 ,{'sub': 1', '2', '3, 'Xis N, Xis CH, and Xis CH;'}{'sub': 1', '2', '3, 'Xis CH, Xis N, and Xis CH; or'}{'sub': 1', '2', '3, 'Xis CH, Xis CH, and Xis N.'}3. The condensed cyclic compound of claim 1 , wherein claim 1 , in Formula 1 claim 1 ,{'sub': 1', '2, 'Land Lare each independently selected from'}a phenylene group, a pyridinylene group, a pyrimidinylene group, a pyrazinylene group, a pyridazinylene group, a triazinylene group, a dibenzofuranylene group, and a dibenzothiophenylene group; and{'sub': 1', '10', '1', '10', '10', '11', '12', '10', '12', '1', '60', '1', '60', '3', '60', '1', '60', '3', '60', '1', '60', '6', '60', '1', '60, 'a phenylene group, a pyridinylene group, a pyrimidinylene group, a pyrazinylene group, a pyridazinylene group, a triazinylene group, a dibenzofuranylene group, and a dibenzothiophenylene group, each substituted with at least one selected from a deuterium, —F, —Cl, —Br, —I, a hydroxyl group, a cyano group, a nitro group, an amino group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a C-Calkyl group, a C-Calkoxy group, a phenyl group, a naphthyl group, a pyridinyl group, a pyrimidinyl group, a pyrazinyl group, a pyridazinyl group, a triazinyl group, and —Si(Q)(Q)(Q), wherein Qto Qare each independently selected from a hydrogen, a C-Calkyl group, a C-Calkoxy group, a C-Ccycloalkyl group, a C-Cheterocycloalkyl group, a C-Ccycloalkenyl group, a C-Cheterocycloalkenyl group, a C-Caryl group, and a C-Cheteroaryl group.'}4. The condensed cyclic compound of claim 1 , wherein claim 1 , in Formula 1 claim 1 ,{'sub': 1', '2, 'Land Lare each independently selected from'}a phenylene group, a pyridinylene group, a pyrimidinylene group, and a triazinylene group; and{'sub': 10', ' ...

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Номер записи: 11
12-01-2017 дата публикации

PROCESS FOR MAKING 2-CHLORO-5-METHYLPYRIDINE

Номер: US20170008846A1
Автор: GRENDZE Martin, MURUGAN Ramiah
Принадлежит: VERTELLUS SPECIALTIES INC.

Processes for the preparation of 2-chloro-5-methylpyridine are described. 2. The process of further comprising the step of{'sub': 3', '3, 'b) contacting the 3-methylpyridine N-oxide in the diluent with aluminum chloride (AlCl) prior to contacting with POCl, and the hindered cyclic amine.'}3. The process of wherein the amount of AlClper mole of 3-methylpyridine N-oxide is about 0.1 mole to about 0.3 mole.4. The process of wherein the amount of AlClper mole of 3-methylpyridine N-oxide is about 0.2 mole to about 0.25 mole.5. The process of wherein the diluent is selected from pentane claim 1 , hexane claim 1 , heptane claim 1 , octane claim 1 , cyclohexane claim 1 , methylcyclohexane claim 1 , petroleum ether claim 1 , naphtha claim 1 , ligroin claim 1 , benzene claim 1 , toluene claim 1 , xylenes claim 1 , methylene chloride claim 1 , chloroform claim 1 , tetrachloromethane claim 1 , 1 claim 1 ,2-dichloroethane claim 1 , chlorobenzene claim 1 , dichlorobenzene claim 1 , diethyl ether claim 1 , dipropyl ether claim 1 , diisopropyl ether claim 1 , dibutyl ether claim 1 , methyl tert-butyl ether claim 1 , glycol dimethyl ether claim 1 , diglycol dimethyl ether claim 1 , tetrahydrofuran claim 1 , dioxane claim 1 , methyl acetate claim 1 , ethyl acetate claim 1 , propyl acetate claim 1 , butyl acetate amyl acetate claim 1 , acetonitrile claim 1 , and propionitrile.6. The process of wherein the diluent is methylene chloride.7. The process of wherein the amount of POClper mole of 3-methylpyridine N-oxide is about 1 to about 5 moles.8. The process of wherein the amount of POClper mole of 3-methylpyridine N-oxide is about 1.5 to about 2.5 moles.9. The process of wherein the amount of POClper mole of 3-methylpyridine N-oxide is about 2 moles.10. The process of wherein the amount of the hindered cyclic amine per mole of 3-methylpyridine N-oxide is about 1 to about 5 moles.11. The process of wherein the amount of the hindered cyclic amine per mole of 3-methylpyridine N-oxide is ...

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Номер записи: 12
17-02-2022 дата публикации

TRICYCLIC OCTACATIONIC CYCLOPHANE AND ITS USE IN COMPLEXATION WITH PERLENE DIIMIDE DYES

Номер: US20220048860A1
Автор: LIU Wenqi, Stoddart James Fraser
Принадлежит:

Disclosed herein is a tricyclic octacationic cyclophane and complexes comprising the tricyclic octacationic cyclophane and a perylene diimide dye complexed therein and methods of using and making the cyclophane and complexes. 1. A tricyclic octacationic cyclophane or a salt thereof , the cyclophane comprising a roof , a floor , and four pillars , wherein each of the roof and the floor are composed of a biphenyl unit having four pyridinium units extending therefrom and wherein each of the four pyridinium units of the roof are linked to another pyridinium unit of the floor by one of the four pillars.3. A receptor-substrate complex claim 1 , the complex comprising the tricyclic octacationic cyclophane according to and a perylene diimide dye complexed therein.6. The complex of claim 5 , wherein R is —CHCHNMeor —CHCH[OCHCH]OMe.7. A salt comprising the cyclophane of and a counter anion.8. The salt of claim 7 , wherein the counter anion is CFCO claim 7 , PF claim 7 , or Cl.9. A crystalline composition comprising the complex of .10. The crystalline composition of claim 9 , wherein the crystalline composition has a triclinic claim 9 , space group P-1 (no. 2) crystal parameter and wherein the crystalline composition has unit cell parameters: a=11.0±0.1 claim 9 , b=15.9±0.1 claim 9 , c=19.3±0.1 Å claim 9 , α=99.2±0.1° claim 9 , β=99.1±0.1° claim 9 , and γ=104.4±0.1°.11. The crystalline composition of claim 9 , wherein the crystalline composition has a tetragonal claim 9 , space group P422 crystal parameter and wherein the crystalline composition has unit cell parameters: a=40.1±0.1 claim 9 , and c=10.8±0.1.12. A method for fluorescence spectroscopy claim 3 , comprising providing the complex of claim 3 , irradiating the complex with an irradiation source claim 3 , and detecting an emission signal from the complex.13. The method of further comprising providing a dye and detecting an emission signal from the dye.14. The method of claim 13 , wherein the complex and the dye are ...

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Номер записи: 13
06-02-2020 дата публикации

CATALYTIC HYDROGENATION OF NITRILES

Номер: US20200039936A1
Автор: Himmler Thomas, Moradi Wahed Ahmed, MUELLER Thomas Norbert
Принадлежит:

The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of Raney catalysts, in particular Raney nickel or cobalt. 3. The process according to claim 1 ,Wherein p is 1 or 2;X is independently of the others, as being fluorine, chlorine, or difluoromethyl, trifluoromethyl, dichloromethyl, trichloromethyl; andthe 2-pyridyl moiety is substituted by X in 3- and/or in 5-position.4. The process according to claim 1 ,Wherein the compound according to formula (III) is 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine.5. The process according to claim 1 ,Wherein the Raney catalyst is Raney Cobalt. The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, wherein the substitution is present on the pyridine ring, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to the corresponding substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts such as in particular Raney catalysts.Substituted 2-methyl cyanopyridyl derivatives, wherein the substitution is present on the pyridine ring, such as in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile are important intermediates for the preparation of Fluopyram (N-[2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl]-2-(trifluoromethyl)benzamide), a commercially available fungicide, according to formula (Ia) shown belowThe production of Fluopyram is disclosed in WO-A 2004/16088.In general the catalytic hydrogenation of nitriles is well known in the literature and can be carried out with different catalysts under either ...

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Номер записи: 14
06-02-2020 дата публикации

PROCESS FOR THE PREPARATION OF A 2-PYRIDYLETHYLCARBOXAMIDE DERIVATIVE

Номер: US20200039937A1
Автор: BIELEFELDT Dietmar, Gertzmann Rolf, HAVEKOST Dirk, Moradi Wahed Ahmed, Schnatterer Albert
Принадлежит:

Described is a process for the preparation of a N-[2-(2-pyridinyl)ethyl]carboxamide derivative of general formula (I) or a salt thereof 2. A process according to claim 1 , wherein p is 1.3. A process according to claim 1 , wherein X is chosen claim 1 , independently of the others claim 1 , as being chlorine or CF.4. A process according to claim 1 , wherein the 2-pyridyl moiety is substituted by X in 5-position.5. A process according to claim 1 , wherein Ris a hydrogen atom claim 1 , a methyl group claim 1 , CF claim 1 , CHF claim 1 , CClFor CCl.6. A process according to claim 1 , wherein Ris a hydrogen atom.7. A process according to claim 1 , wherein A is a phenyl group.8. A process according to claim 7 , wherein A is substituted by one or two substituents claim 7 , the substituent of A is chosen claim 7 , independently of each other claim 7 , as being chlorine or CF.9. A process according to claim 7 , wherein the A is substituted in ortho position.10. A process according to claim 1 , wherein the compound of formula (I) is:N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-trifluoromethylbenzamide.11. A process according to claim 1 , wherein A is conducted in the presence of an organic solvent or a mixture thereof.12. A process according to claim 1 , wherein A is conducted at reduced pressure.13. A process according to claim 1 , wherein C is conducted in a two-phase system. in the absence of solvent.14. A process according to claim 1 , wherein C is conducted in an one-phase system.15. A process according to claim 1 , wherein C is conducted in the absence of solvent in a molten state. The present invention relates to a novel process for the preparation of N-[2-(2-pyridinyl)ethyl]carboxamide derivative which is useful as pesticide compound, starting with a halogenobenzoyl derivative to produce a N-acetoxymethylcarboxamide derivative and then coupling it with a 2-pyridyl acetate derivative.Patent application WO 2004/016088 discloses the preparation of N-[2-(2- ...

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Номер записи: 15
14-02-2019 дата публикации

Preparation Of Difluoro Chelato Borate Salts

Номер: US20190048025A1
Автор: HERBEL Juergen, HOLUB Nicole
Принадлежит: Gotion, Inc.

A process for preparing a difluoro chelato borate salt comprising an anion A of formula (I) 2. The process according to claim 1 , wherein the total content of additional sources for F-atoms is less than 50 mol.-% based on the total amount of BF-source (a).3. The process according to claim 1 , wherein the volatile reaction products are removed during and/or after step (i).4. The process according to claim 1 , wherein an organic solvent or solvent mixture (e) is present in the reaction mixture of step (i).5. The process according to claim 1 , wherein the BFsource (a) is selected from BF claim 1 , BFhydrate claim 1 , BFetherates claim 1 , BF-alcohol adducts claim 1 , BF-acetonitril adduct claim 1 , BF-acetic acid adduct claim 1 , and BF-amine adducts.6. The process according to claim 1 , wherein the dihydric compound (b) is selected from 1 claim 1 ,2-diols claim 1 , 1 claim 1 ,2-dicarboxylic acids claim 1 , and 1 claim 1 ,2-hydroxycarboxylic acids.7. The process according to claim 1 , wherein the dihydric compound (b) is selected from oxalic acid claim 1 , salicylic acid claim 1 , and phthalic acid.8. The process according to claim 1 , wherein the second boron source (c) is selected from boric acid claim 1 , B(OC-Calkyl) claim 1 , B(OC-C(hetero)aryl) claim 1 , and ammonium and alkali metal salts of borate complexes of the dihydric compound used as component (b).9. The process according to claim 1 , wherein the dihydric compound (b) is oxalic acid and the second boron source (c) is selected from boric acid claim 1 , lithium bis(oxalato) borate claim 1 , triethylammonium bis(oxalato)borate claim 1 , and mixtures thereof.10. The process according to claim 1 , wherein the proton acceptor (d) is selected from ammonia claim 1 , organic amines claim 1 , organic ammonium hydroxides claim 1 , NHOH claim 1 , and nitrogen containing aromatic heterocycles.11. The process according to claim 1 , wherein the proton acceptor (d) is selected from organic amines NRRR claim 1 , NHOH ...

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Номер записи: 16
25-02-2021 дата публикации

ESTER NITRATES DERIVATIVES OF AROMATIC ALDEHYDES WITH MULTIPLE PHARMALOGIC PROPERTIES TO TREAT SICKLE CELL DISEASE

Номер: US20210053931A1
Автор: Danso-Danqua Richmond, Deshpande Tanvi, Safo Martin, VENITZ Jurgen, Zhang Yan
Принадлежит:

The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention. 157-. (canceled) The invention relates to aromatic aldehydes and their use in the treatment of Sickle Cell Disease.Sickle cell disease (SCD) is the consequence of substitution of Glu by Val in the 6position of the β-globin chain of hemoglobin (Hb) resulting in the formation of sickle Hb (HbS). Intracellular polymerization of deoxygenated sickle Hb into long, rigid and insoluble fibres causes the pathophysiology associated with SCD; facilitating a cascade of adverse events that include decreased nitric oxide (NO) bioavailability, endothelial cell activation, compensatory vasoconstriction, increase in neutrophil count, adhesion of red blood cells (RBCs) to tissue endothelium, vaso-occlusion and impaired microvascular blood flow. The clinical condition is characterized by chronic hemolytic anemia, frequent and severe painful crises, and multi-system pathology that impact nearly every organ.Individuals with SCD have shown significant levels of pro-inflammatory cytokines, such as TNF-α which can trigger the painful vaso-occlusive crises and lead to the emergence of infectious and inflammatory episodes. TNF-α also stimulates production of free radicals and other inflammatory mediators, such as IL-1 and PGE2, and induce changes in coagulant and anticoagulant properties. Individuals with SCD have also shown decreased NO physiological levels in vascular endothelium that have also been linked to hemolysis, inflammation, vaso-occlusion and multiple organ stress. Produced naturally by the vascular endothelium, NO provides favorable microvasculature effects (i.e., dilation and increased blood flow), and ...

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Номер записи: 17
22-02-2018 дата публикации

ELECTROCHEMICAL REDUCTION OF CARBON DIOXIDE

Номер: US20180050330A1
Автор: ISHITANI Osamu
Принадлежит: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Disclosed herein is a method for selectively reducing, using electrical energy, COto carbon monoxide or formic acid, a catalyst for use in the method, and an electrochemical reduction system. The method for producing carbon monoxide or formic acid by electrochemically reducing carbon dioxide of the present invention includes (a) reacting carbon dioxide with a metal complex represented by formula (1), and (b) applying a voltage to a reaction product of the carbon dioxide and the metal complex represented by formula (1): 2. The production method according to claim 1 , wherein the steps (a) and (b) are performed within an electrochemical cell including a working electrode and a counter electrode claim 1 , and the method comprises:(a1) introducing carbon dioxide into a solution comprising the metal complex held in the electrochemical cell; and(b1) applying a negative voltage and a positive voltage respectively to the working electrode and the counter electrode of the electrochemical cell.3. The production method according to claim 2 , wherein the carbon dioxide is introduced by introducing a carbon dioxide-containing gas into the solution containing the metal complex.4. The production method according to claim 1 , wherein the carbon dioxide to be reacted is a gas containing 0.03 to 100% of carbon dioxide.5. The production method according to claim 1 , wherein the nitrogen atom-containing heterocycle is a heterocycle having a 2 claim 1 ,2′-bipyridine structure optionally having a substituent.6. The production method according to claim 1 , wherein each hydrocarbon group optionally having a substituent represented by R claim 1 , R claim 1 , R claim 1 , R claim 1 , X claim 1 , Xand Xis one selected from the group consisting of an alkyl group claim 1 , an alkenyl group claim 1 , a cycloalkyl group claim 1 , a cycloalkenyl group and an aromatic hydrocarbon group claim 1 , each of which optionally has one to three substituents selected from the group consisting of a primary ...

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Номер записи: 18
13-02-2020 дата публикации

Method for separating and purifying 2-chloro-3-trifluoromethylpyridine

Номер: US20200048202A1
Автор: Takayoshi Ando
Принадлежит: Ishihara Sangyo Kaisha Ltd

A method for separating and purifying 2-chloro-3-trifluoromethylpyridine useful as an intermediate for medicines, agrochemicals, and the like is provided. The method includes: 1) in the process of producing chloro β-trifluoromethylpyridine compounds by allowing a β-methylpyridine compound to react with chlorine and hydrogen fluoride in a reaction apparatus, allowing a β-trifluoromethylpyridine compound to react with chlorine in a reaction apparatus, or allowing a chloro β-trichloromethylpyridine compound to react with hydrogen fluoride in a reaction apparatus, 2) fractionating a liquid mixture containing chloro β-trifluoromethylpyridine compounds from the reaction apparatus, and 3) separating and purifying 2-chloro-3-trifluoromethylpyridine from the liquid mixture.

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Номер записи: 19
15-03-2018 дата публикации

MATERIALS FOR USE IN AN AQUEOUS ORGANIC REDOX FLOW BATTERY

Номер: US20180072669A1
Автор: DeBruler Camden, Hu Bo, Liu Tianbiao, LUO Jian
Принадлежит: Utah State University

Described herein are aqueous organic redox flow batteries that include a first redox active material that can include a metallocene or a salt thereof, and a second redox active material that can include a viologen or a salt thereof. The aqueous organic redox flow batteries may further include a first aqueous electrolyte, a second aqueous electrolyte, and a separator between the first and second aqueous electrolytes. In addition, disclosed herein are methods of making the metallocene and viologen compounds. 4. The redox flow battery of claim 3 , wherein:{'sup': 13', '−, 'sub': 3', '2', '2', 'm', '2, 'Ris —SO, —(OCHCH)—OCH, Or substituted aryl;'}{'sup': 14', '−, 'sub': 3', '2', '2', 'm', '2, 'Ris —SO, —(OCHCH)—OCH, or substituted aryl;'}{'sup': +', '+', '−', '−, 'V, at each occurrence, is independently Na, K, Cl, Br or a combination thereof;'}r is 2, 3 or 4;u is 1; andc, at each occurrence, is independently 1, 2 or 3.8. The redox flow battery of claim 1 , wherein the first redox active material comprises —[Fe(CN)] claim 1 , I/I claim 1 , Br/Br claim 1 , S/S claim 1 , KBr claim 1 , NaBr claim 1 , NHBr claim 1 , KI claim 1 , NaI claim 1 , NHI claim 1 , FeCl claim 1 , FeBr claim 1 , Ce claim 1 , Mn claim 1 , PbO/PbSO claim 1 , quinines claim 1 , anthraxquinines claim 1 , K[Fe(CN)] claim 1 , N[Fe(CN)] claim 1 , (NH)[Fe(CN)] claim 1 , V claim 1 , (2 claim 1 ,2 claim 1 ,6 claim 1 ,6-Tetramethylpiperidin-1-yl)oxyl (TEMPO) claim 1 , a derivative of TEMPO claim 1 , or a combination thereof.11. The redox flow battery of claim 8 , wherein the derivative of TEMPO is selected from the group consisting of 4-trimethylammonium-(2 claim 8 ,2 claim 8 ,6 claim 8 ,6-Tetramethylpiperidin-1-yl)oxy (4-N-TEMPO) claim 8 , 4-dimethyl(propyl-3-N claim 8 ,N claim 8 ,N claim 8 ,-trimethylammonium)-(2 claim 8 ,2 claim 8 ,6 claim 8 ,6-Tetramethylpiperidin-1-yl)oxy ((4-N-TEMPO) claim 8 , 4-hyoxyl-ammonium-(2 claim 8 ,2 claim 8 ,6 claim 8 ,6-Tetramethylpiperidin-1-yl)oxy (4-OHTEMPO) claim 8 , 4- ...

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Номер записи: 20
16-03-2017 дата публикации

SUPRAMETALLOGELS AND USES THEREOF

Номер: US20170073311A1
Автор: Grindy Scott Charles, Holten-Andersen Niels, Johnson Jeremiah A., Kawamoto Ken, Zhukhovitskiy Aleksandr V.
Принадлежит: Massachusetts Institute of Technology

The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder). 15. The macromer of claim 1 , wherein each instance of Ris hydrogen claim 1 , and each instance of Ris hydrogen.16. The macromer of claim 1 , wherein each one of m and n is 0.17. The macromer of claim 1 , wherein each one of Zand Zis a bond.19. The macromer of claim 1 , wherein Y is a substituted or unsubstituted claim 1 , saturated or unsaturated Chydrocarbon chain claim 1 , optionally wherein not more than one half of all instances of the chain atoms of the hydrocarbon chain are independently replaced with —O— ...

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Номер записи: 21
26-03-2015 дата публикации

Organic Electroluminescent Devices and Metal Complex Compounds

Номер: US20150084028A1
Автор: Kazumi Nii, Kousuke Watanabe, Seiji Ichijima, Tatsuya Igarashi, Toshiro Ise
Принадлежит: UDC Ireland Ltd

An organic electroluminescent device, which has a pair of electrodes and at least one organic layer including a luminescent layer between the pair of electrodes, wherein at least one layer between the pair of electrodes comprises at least one metal complex having a tridentate- or higher polydentate-chain structure ligand.

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Номер записи: 22
22-03-2018 дата публикации

Organic Electroluminescent Devices and Metal Complex Compounds

Номер: US20180083208A1
Автор: Ichijima Seiji, Igarashi Tatsuya, Ise Toshiro, Nii Kazumi, WATANABE Kousuke
Принадлежит:

An organic electroluminescent device, which has a pair of electrodes and at least one organic layer including a luminescent layer between the pair of electrodes, wherein at least one layer between the pair of electrodes comprises at least one metal complex having a tridentate- or higher polydentate-chain structure ligand. 125.-. (canceled)27. The organic electroluminescent device of claim 26 , wherein in the complex represented by formula (6) claim 26 , at least one ring formed with Qor Qis a benzene ring claim 26 , a pyridine ring claim 26 , a thiophene ring claim 26 , a thiazole ring claim 26 , or a condensed ring thereof.28. The organic electroluminescent device of claim 26 , wherein in the complex represented by formula (6) claim 26 , Yand Yeach independently represent a single bond claim 26 , a carbonyl-linking group claim 26 , an alkylene linking group claim 26 , or an alkenylene group.29. The organic electroluminescent device of claim 26 , wherein in the complex represented by formula (6) claim 26 , Yis a single bond or an alkylene group.30. The organic electroluminescent device of claim 26 , wherein the organic layer comprises at least one luminescent layer and a hole transporting layer claim 26 , and the organic layer further comprises at least one layer selected from the group consisting of an exciton-blocking layer claim 26 , a hole injection layer claim 26 , a hole-blocking layer and an electron-transporting layer.31. The organic electroluminescent device of claim 26 , wherein the organic layer comprises at least one luminescent layer claim 26 , and a host material of the luminescent layer is selected from the group consisting of an amine compound claim 26 , a metal chelate oxynoid compound in which the metal is aluminum claim 26 , zinc or transition metals claim 26 , a polyarylene compound claim 26 , a condensed aromatic carbocyclic compound claim 26 , and a non-complex aromatic heterocyclic compound.32. The organic electroluminescent device of claim 26 ...

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Номер записи: 23
21-03-2019 дата публикации

Antireflective compositions with thermal acid generators

Номер: US20190085173A1
Автор: Jae Bong Lim, Jung-June Lee
Принадлежит: Rohm and Haas Electronic Materials Korea Ltd

New methods and substrates are provided that include antireflective compositions that comprise one or more thermal acid generators.

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Номер записи: 24
30-03-2017 дата публикации

Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones

Номер: US20170088518A1
Автор: LEUNG-TOUNG Regis, Shah Birenkumar, TAM Tim Fat, WANG Yingsheng, Xin Tao, ZHAO Yanqing
Принадлежит:

Provided are compounds of Formula I which are derivatives of 3-Hydroxypyridin-4-ones. The compounds may be used in treatment of a medical condition related to a toxic concentration of iron. The compounds may be used for preparation of a medicament for treatment of a medical condition related to a toxic concentration of iron. The medical condition related to a toxic concentration of iron may be selected from the group consisting of: cancer, pulmonary disease, progressive kidney disease and Friedreich's ataxia. 2. The compound of or pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': '1', 'sub': 1', '4, 'Gis C-Calkyl;'}{'sup': '2', 'sub': 1', '4, 'Gis H, C-Calkyl or cyclopropyl;'}{'sup': '3', 'sub': 1', '4, 'Gis H or C-Calkyl; and'}{'sup': 4', '8, 'sub': '3', 'Gis CH(R)CF, wherein'}{'sup': '8', 'Ris 1,2,4-triazolyl, N-phenylpiperazinyl, N-benzylpiperazinyl, 2-pyridylpiperazinyl or morpholinyl.'}3. The compound of or pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': 1', '1', '2', '1', '2, 'sub': '2', 'Gis CHNRR, where NRRis morpholinyl;'}{'sup': 2', '3, 'sub': 2', '2, 'Gis CHCFR;'}{'sup': '3', 'sub': 1', '4, 'Gis H or C-Calkyl; and'}{'sup': '4', 'sub': 1', '4, 'Gis H or C-Calkyl, wherein'}{'sup': '3', 'Ris F or H.'}4. The compound of or pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': 1', '4, 'sub': '3', 'Gis CH(R)CF;'}{'sup': '2', 'sub': 1', '4, 'Gis H, C-Calkyl or cyclopropyl;'}{'sup': '3', 'sub': 1', '4, 'Gis H or C-Calkyl; and'}{'sup': '4', 'sub': 1', '4, 'Gis H or C-Calkyl, wherein'}{'sup': '4', 'Ris imidazolyl, 1,2,4-triazolyl, N-phenylpiperazinyl, N-benzylpiperazinyl, 2-pyridylpiperazinyl or morpholinyl.'}5. The compound of or pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': 1', '7, 'sub': '2', 'Gis CH(R)CFH;'}{'sup': '2', 'sub': 1', '4, 'Gis H, C-Calkyl or cyclopropyl;'}{'sup': '3', 'sub': 1', '4, 'Gis H or C-Calkyl; and'}{'sup': '4', 'sub': 1', '4, 'Gis H or C-Calkyl, wherein'}{'sup': '7', ' ...

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Номер записи: 25
26-06-2014 дата публикации

Dinitro monomer, diamine monomer, polyimide and modified polyimide

Номер: US20140179878A1
Автор: Bo-Cheng Tao, Der-Jang Liaw, Wen-Hsiang Chen, Ying-Chi Huang
Принадлежит: TAIWAN TEXTILE RESEARCH INSTITUTE

A polyimide including a structure shown as Formula II is provided, wherein X is halogen, A 1 is selected from one of Formula 1 to Formula 18, and n is from 2 to 500,

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Номер записи: 26
26-03-2020 дата публикации

Deep Eutectic Solvent Compositions

Номер: US20200095400A1
Автор: McCune Jade A., Scherman Oren A.
Принадлежит:

Disclosed herein are compositions of a deep eutectic solvent with a host, such as a supramolecular host, and the use of the composition to form a composition comprising the host in complex with one or more guests. The deep eutectic solvent provides an alternative medium to the aqueous-based media that have been used in the art to date. Also disclosed are compositions of a deep eutectic solvent with a redox-active compound, such as a viologen compound, and the use of the composition, for example, in a smart window or for agricultural use, such as in an agricultural product. 1. A composition comprising a deep eutectic solvent and a macrocyclic host.2. The composition of claim 1 , further comprising the deep eutectic solvent and the macrocyclic host in complex with one or more guests.3. (canceled)4. The composition according to claim 1 , wherein the host is selected from the group consisting of cucurbituril claim 1 , cyclodextrin claim 1 , calix[n]arene claim 1 , and crown ether.5. The composition according to claim 4 , wherein the host is a cucurbituril host selected from the group consisting of CB[5] claim 4 , C[6] claim 4 , CB[7] and CB[8] or a cyclodextrin host selected from the group consisting of α- claim 4 , β- and γ-cyclodextrin.6. (canceled)7. (canceled)8. (canceled)9. The composition according to claim 1 , wherein the deep eutectic solvent is a Type III deep eutectic solvent claim 1 , which comprises a first component that is an ionic species and a second component that is a hydrogen bond donor.10. The composition according to claim 9 , wherein the ionic species comprises an ammonium claim 9 , phosphonium or sulfonium cation claim 9 , and a Lewis base anion.11. (canceled)12. The composition according to claim 10 , wherein the ionic species comprises an ammonium cation selected from the group consisting of choline chloride claim 10 , ethylammonium chloride claim 10 , N-ethyl-2-hydroxy-N claim 10 ,N-dimethylethanaminium chloride claim 10 , 2-(chlorocarbonyloxy ...

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Номер записи: 27
03-07-2014 дата публикации

BISACODYL AND ITS ANALOGUES AS DRUGS FOR USE IN THE TREATMENT OF CANCER

Номер: US20140186872A1
Автор: Chneiweiss Hervé, Feve Marie, Haiech Jacques, Hibert Marcel, Kilhoffer Marie-Claude, Mameri Samir, Zeniou-Meyer Maria
Принадлежит:

The present invention provides compounds having the formula A: (A) or pharmaceutically acceptable salt thereof, wherein W, R1, R2 and R5 are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as cytotoxic agents towards proliferating and/or quiescent cancer stem cells, and thus are useful, for example, for the treatment of cancer. 6. Compound as recited in claim 1 , wherein the compound is in an amount to detectably exhibit cytotoxic activity towards proliferating and/or quiescent cancer stem cells.7. Compound as recited in wherein when said compound possesses cytotoxicity activity towards quiescent cancer stem cells.8. Compound according to for use as a medicinal product intended for treating cancers comprising cancer stem cells and tumour initiating cells present in the group of tumours comprising glioblastomas claim 1 , melanomas claim 1 , mammary tumours claim 1 , tumours of the colon claim 1 , prostate claim 1 , kidney claim 1 , pancreas claim 1 , lung claim 1 , or bones.9. Compound as recited in claim 1 , for use in combination with a therapeutic agent selected from a chemotherapeutic or anti-proliferative agent claim 1 , an anti-inflammatory agent claim 1 , an immunomodulatory or immunosuppressive agent claim 1 , a neurotrophic factor claim 1 , an agent for treating cardiovascular disease claim 1 , an agent for treating destructive bone disorders claim 1 , an agent for treating liver disease claim 1 , an anti-viral agent claim 1 , an agent for treating blood disorders claim 1 , an agent for treating diabetes claim 1 , or an agent for treating immunodeficiency disorders.10. Compound as recited in claim 9 , wherein the additional therapeutic agent is an anti-proliferative agent.11. Compound as recited in for use in exhibiting cytotoxic activity in proliferating and/or quiescent cancer stem cells.12. Compound as recited in for use in treating primary ...

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Номер записи: 28
02-04-2020 дата публикации

METHOD FOR PREPARING 2,3-DICHLORO-5-TRIFLUOROMETHYLPYRIDINE WITH HIGH SELECTIVITY

Номер: US20200102273A1
Автор: CHEN Xianjin, LIN Shengda, LIU Minyang, LIU Wucan, YU Wanjin, Zhang Jianjun
Принадлежит:

The present invention discloses a method for preparing 2,3-dichloro-5-trifluoromethylpyridine, comprising at a temperature of 100˜150° C. and a pressure of 0.5˜5.0 MP, in presence of at least one catalyst selected from supported metal chloride, supported zeolite molecular sieve and supported heteropolyacid, 2-chloro-5-trifluoromethylpyridine reacts with chlorine gas to obtain 2,3-dichloro-5-trifluoromethylpyridine. The preparing method provided by the present invention has advantages such as high selectivity of desired product, high utilization rate of chlorine gas, moderate process condition, simple operation and less three wastes. The present invention also discloses a preparing method for preparing 2-chloro-5-trifluoromethylpyridine, which is capable of reducing unit consumption, reducing separation cost, and improving safety compared to the prior art. 211-. (canceled)12. The method for preparing 2 claim 1 ,3-dichloro-5-trifluoromethylpyridine according to claim 1 , wherein the chlorination catalyst is selected from fluoride claim 1 , oxide or chloride of magnesium claim 1 , calcium claim 1 , a supported palladium catalyst supported on activated carbon or aluminium fluoride.13. The method for preparing 2 claim 1 ,3-dichloro-5-trifluoromethylpyridine according to claim 1 , wherein the chlorofluorination temperature is 220˜260° C. claim 1 , and chlorination temperature is 270˜320° C.14. The method for preparing 2 claim 1 ,3-dichloro-5-trifluoromethylpyridine according to claim 1 , wherein the chlorofluorination catalyst includes a main catalyst claim 1 , a first co-catalyst and a second co-catalyst claim 1 , the main catalyst is at least one selected from aluminium claim 1 , magnesium and chromium claim 1 , the first co-catalyst is at least one selected from iron claim 1 , cobalt claim 1 , manganese claim 1 , nickel claim 1 , copper claim 1 , bismuth and zinc claim 1 , the second co-catalyst is at least one selected from lanthanium claim 1 , cerium claim 1 , barium ...

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Номер записи: 29
09-06-2022 дата публикации

INERT NANOCAPSULES

Номер: US20220177431A1
Автор: ARCHIBALD Steve, Burke Benjamin, Burke Michael, GRANTHAM William, LUSBY Paul
Принадлежит:

Compounds are presented having the formula [ML].X, where M is a transition metal ion having 6 d-shell valence electrons, X is a counter ion and n is the number of counterions such that the total charge of the compound of formula (I) is zero, and wherein L is a 5-(5-bipyridin-2,2′-yl)-2,2′-bipyridine or derivative thereof. Methods of preparing the compounds and uses of the compounds to retain radiolabels are also presented. 2. A compound according to claim 1 , wherein M is selected from cobalt(III) claim 1 , rhodium(III) iridium(III) claim 1 , iron(II) claim 1 , ruthenium(II) claim 1 , or osmium(II).3. A compound according to claim 2 , wherein M is cobalt (III).5. A compound according to claim 4 , wherein the targeting moiety is a small molecule claim 4 , peptide claim 4 , protein or antibody.6. A compound according to claim 5 , wherein the targeting moiety has a high affinity for a target site such that when administered claim 5 , the compound binds to the target site via the targeting moiety.8. A compound according to claim 7 , wherein Rand Rare NHand Rand Rare H.9. A compound according to claim 1 , wherein the compound is configured to capture and retain an anionic target species.10. A compound according to claim 9 , wherein the anionic target species is a radiolabel anion.11. A compound according to formula VI;{'br': None, 'sub': 4', '6', 'n, '[T⊂ML].X\u2003\u2003(VI)'}{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'wherein T is a target species retained within the cavity of the compound according to formula I; and wherein L, M, X and n are as defined in .'}12. The compound of claim 11 , wherein T is an anionic target species comprising a radioactive isotope selected from the group carbon-11 (C) claim 11 , fluorine-18 (F) claim 11 , copper-64 (Cu) claim 11 , gallium-68 (Ga) claim 11 , zirconium-89 (Zr) claim 11 , gallium-67 (Ga) claim 11 , technetium-99m (Tc) claim 11 , indium-111 (In) claim 11 , copper-67 (Cu) claim 11 , rhenium-186 (Re) claim 11 , rhenium- ...

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Номер записи: 30
26-04-2018 дата публикации

ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME

Номер: US20180114927A1
Автор: AHN Heechoon, HWANG Seokhwan, JUN Mieun, KIM Sungbum, Kim Youngkook, KO Soobyung
Принадлежит:

An organometallic compound and an organic light-emitting device including the same are provided. The organometallic compound has Formula 1: 2. The organometallic compound of claim 1 , whereinM in Formula 1 is iridium or osmium and the sum of n1 and n2 is three; orM in Formula 1 is platinum and the sum of n1 and n2 is two.3. The organometallic compound of claim 1 , wherein{'sub': 1', '1', '2', '2', '3', '3, 'in Formula 2A, Xis C(R), Xis C(R), and Xis C(R); or'}{'sub': 1', '1', '2', '3', '3, 'in Formula 2A, Xis C(R), Xis N, and Xis C(R).'}4. The organometallic compound of claim 1 , wherein claim 1 ,{'sub': 3', '3', '3, 'in Formula 2A, Xis C(R) and Ris an electron withdrawing group.'}5. The organometallic compound of claim 1 , wherein{'sub': 1', '2, 'ring Aand ring Ain Formula 2B are each independently a pyridine group, a pyrimidine group, a pyrazine group, a pyridazine group, a triazine group, a quinoline group, an isoquinoline group, a quinoxaline group, a quinazoline group, a phenanthroline group, a pyrazole group, an imidazole group, a triazole group, an oxazole group, an iso-oxazole group, a thiazole group, an isothiazole group, an oxadiazole group, a thiadiazol group, a benzopyrazole group, a benzimidazole group, a benzoxazole group, a benzothiazole group, a benzoxadiazole group, a benzothiadiazol group, a 5,6,7,8-tetrahydroisoquinoline group, or a 5,6,7,8-tetrahydroquinoline group.'}6. The organometallic compound of claim 1 , wherein{'sub': 1', '3', '5', '6', '11', '12, 'Rto R, R, R, R, and Rin Formulae 2A and 2B are each independently selected from{'sub': 1', '20', '2', '20', '2', '20', '1', '20, 'hydrogen, deuterium, —F, —Cl, —Br, —I, a hydroxyl group, a cyano group, a nitro group, an amidino group, a hydrazino group, a hydrazono group, a C-Calkyl group, a C-Calkenyl group, a C-Calkynyl group, and a C-Calkoxy group;'}{'sub': 1', '20', '2', '20', '2', '20', '1', '20', '3', '2', '2', '3', '2', '2', '31', '32', '33', '31', '32', '31', '32', '31', '2', '31', '31', ...

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Номер записи: 31
31-07-2014 дата публикации

METHOD FOR PRODUCING OPTICALLY ACTIVE 2-ARYLPIPERIDINIUM SALT

Номер: US20140213792A1
Автор: HIDA Shoji, Hori Kiyoto, IIMURO Atsuhiro, Kita Yusuke, Mashima Kazushi, NAGANO Takuto, Nara Hideki, YAMAJI Kenta
Принадлежит: TAKASAGO INTERNATIONAL CORPORATION

Disclosed is a method for producing an optically active 2-arylpiperidinium salt, comprising asymmetrically hydrogenating a pyridinium salt in the presence of an iridium complex and hydrogen, the 2-arylpiperidinium salt being represented by the following general formula (1): 3. The production method according to claim 1 , whereinthe optically active bisphosphine of the iridium complex represented by general formula (3) is an optically active DTBM-SEGPHOS, andthe optically active bisphosphine of the iridium complex represented by general formula (4) is an optically active DIFLUORPHOS.4. The production method according to claim 1 , whereinthe iridium complex is the complex represented by general formula (3).5. The production method according to claim 1 , whereinthe HX is hydrogen bromide or hydrogen iodide. The present invention relates to a method for producing an optically active 2-arylpiperidinium salt. More specifically, the present invention relates to a method for producing an optically active 2-arylpiperidinium salt, which is useful as pharmaceuticals, agricultural chemicals, flavors, fragrances, synthetic intermediates thereof, and the like.Since substituted piperidine derivatives having optical activity are useful as pharmaceuticals, agricultural chemicals, flavors, fragrance, synthetic intermediates thereof, and the like, there is a demand for production of piperidines having high optical activity.In general, it is necessary to carry out hydrogenation to the corresponding piperidine by using an achiral palladium catalyst or the like (Heterogeneous Catalysis for the Synthetic Chemist, 1996, chapter 17, 421-424, Japanese Patent Application Publication No. 07-242630, and European Patent No. 350733 (pages 65 and 66)) and further to carry out purification by optical resolution. This means that the other optically active isomer is removed as the by-product, and such loss of the product is also disadvantageous in addition to the costs associated with the ...

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Номер записи: 32
21-05-2015 дата публикации

Pyridine Derivatives And Their Use In The Treatment Of Conditions Associated With Pathological Thrombus Formation

Номер: US20150141471A1
Автор: CZECHTIZKY Werngard, Evers Andreas, KOZIAN Detlef, NAZARE Marc
Принадлежит:

The present invention relates to compounds of the formula (I), wherein the residues Rto R, V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds for use in the treatment of diverse disorders, for example cardiovascular disorders like thromboembolic diseases or restenoses. The compounds of the invention are effective antagonists of the platelet LPA receptor LPAR5 (GPR92) and can in general be applied in conditions in which an undesired activation of the platelet LPA receptor LPAR5, the mast cell LPA receptor LPAR5 or the microglia cell LPA receptor LPAR5 is present, or for the cure or prevention of which an inhibition of the platelet, mast cell or microglia cell LPA receptor LPAR5 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in medicaments, and pharmaceutical compositions comprising them. 2. A compound of the formula I according to claim 1 , wherein{'sup': 1', '2, 'sub': 1', '6', '3', '7', '3', '7', '1', '4', '1', '4, 'Rand Rare independently of each other selected from the series consisting of (C-C)-alkyl, (C-C)-cycloalkyl, (C-C)-cycloalkyl-(C-C)-alkyl-, Ar and Ar—(C-C)-alkyl-;'}{'sup': 3', '4, 'sub': 1', '4', '3', '7, 'Rand Rare independently of each other selected from the series consisting of hydrogen, halogen, (C-C)-alkyl and (C-C)-cycloalkyl;'}{'sup': 5', '6, 'sub': 1', '6, 'Rand Rare independently of each other selected from the series consisting of hydrogen, fluorine and (C-C)-alkyl,'}{'sup': 11', '12', '13', '14, 'sub': 1', '4, 'R, R, Rand Rare independently of each other selected from the series consisting of hydrogen and (C-C)-alkyl;'}{'sub': 1', '4', '3', '7', '1', '4, 'Ar is selected from the series consisting of phenyl and an aromatic, 5-membered or 6-membered, monocyclic heterocycle which comprises one or two identical or different ring heteroatoms selected from N ...

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Номер записи: 33
21-05-2015 дата публикации

PROCESS FOR PRODUCING SUBSTITUTED METHYLAMINE COMPOUND AND TRIAZINE DERIVATIVE

Номер: US20150141653A1
Автор: Imagawa Tsutomu, SHIBATA Yasushi
Принадлежит:

The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid. 113-. (canceled)15. (canceled)17. The process for producing a substituted methylamine compound according to claim 16 , wherein said A is a 2-chloropyridin-5-yl group.18. The process for producing a substituted methylamine compound according to claim 16 , wherein hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II′) is conducted in at least one solvent selected from a group consisting of water claim 16 , alcohol-based solvents claim 16 , aliphatic hydrocarbon-based solvents claim 16 , alicyclic hydrocarbon-based solvents claim 16 , aromatic hydrocarbon-based solvents claim 16 , ketone-based solvents claim 16 , and ether-based solvents.19. The process for producing a substituted methylamine compound according to claim 16 , wherein hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II′) is conducted at an temperature of within a range from room temperature to 90° C. This application is a Continuation application of U.S. application Ser. No. 12/596,950, filed on Oct. 21, 2009, which is a national phase application of PCT/JP2007/058842, filed on Apr. 24, 2007, the contents of each are hereby incorporated by reference.The present invention relates to a process that enables a ...

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Номер записи: 34
17-05-2018 дата публикации

AN ADDITIVE FOR A FLOW BATTERY

Номер: US20180138568A1
Автор: BEN-DAVID Iris, Elazari Ran, Lancry Eli, MAGNES Ben-Zion
Принадлежит:

The invention relates to a method of operating a zinc-bromine battery, especially at a high temperature, comprising adding 1-n-butyl-2-methyl-pyridinium bromide to the electrolyte of said battery, and charging or discharging said cell. Also provided is the use of 1-n-butyl-2-methyl-pyridinium bromide as an additive in a zinc-bromine battery operating at a temperature above 30° C., and an aqueous concentrate with high content of 1-n-butyl-2-methyl-pyridinium bromide. 1. A method of operating a zinc-bromine battery , comprising adding 1-n-butyl-2-methyl-pyridinium bromide to the electrolyte of said battery , and charging or discharging said cell.2. A method according to claim 1 , wherein the battery operates at a temperature above 30° C.3. A method according to claim 2 , wherein the battery operates at a temperature above 40° C.4. An electrolyte solution suitable for use in a zinc-bromine battery claim 2 , comprising zinc bromide and a liquid complex composed of 1-n-butyl-2-methyl-pyridinium bromide combined with one or more bromine molecules.5. Use of 1-n-butyl-2-methyl-pyridinium bromide as an additive in a zinc-bromine battery operating at a temperature above 30° C.6. An aqueous concentrate composition of 1-n-butyl-2-methyl-pyridinium bromide claim 2 , with 1-n-butyl-2-methyl-pyridinium bromide content of more than 75% by weight.7. An aqueous concentrate composition according to claim 6 , wherein the content of 1-n-butyl-2-methyl-pyridinium bromide is from 75% to 85% weight. The invention relates to an additive for zinc-bromine flow batteries. The additive serves as a complexing agent, forming a complex with elemental bromine generated and utilized in zinc-bromine batteries.In its simplest configuration, a zinc-bromine cell contains two chemically non-reactive electrodes and a separator located between the electrodes (e.g., an ion exchange membrane or microporous plastic sheet). The electrolyte used in the cell is an aqueous solution of zinc bromide, which is ...

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Номер записи: 35
24-05-2018 дата публикации

PROCESS FOR THE PREPARATION OF HALOSUBSTITUTED TRIFLUOROMETHYLPYRIDINES

Номер: US20180141908A1
Автор: Anand Rajdeep, BALAJI Prabhu, BORA Pushkar Singh, Kumar Kapil, SONI Chandresh
Принадлежит:

The present invention provides a process for the preparation of halosubstituted-6-trifluoromethyl pyridine of Formula I 3. The process as claimed in claim 2 , wherein the fluorination catalyst is selected from oxides or fluorides of one or more of chromium claim 2 , manganese claim 2 , iron claim 2 , cobalt claim 2 , aluminium or nickel.4. The process as claimed in claim 3 , wherein the catalyst used is either unsupported or supported.5. The process as claimed in claim 2 , wherein step a) or step b) or both are carried out in the presence of pure oxygen.6. The process as claimed in claim 2 , wherein the process is continuous.7. The process as claimed in claim 2 , wherein the inert gas is nitrogen claim 2 , helium and argon.8. The process as claimed in claim 2 , wherein the process is carried out at a temperature in the range of 300° C. to 400° C.9. The process as claimed in claim 2 , wherein the compound of Formula I is isolated from the reaction mixture by filtration claim 2 , decantation claim 2 , layer separation claim 2 , precipitation claim 2 , distillation and evaporation or a mixture thereof.10. The compound of Formula I claim 2 , as obtained in claim 2 , has purity of greater than 97.5%.11. The process as claimed in claim 1 , wherein the fluorination catalyst is selected from oxides or fluorides of one or more of chromium claim 1 , manganese claim 1 , iron claim 1 , cobalt claim 1 , aluminium or nickel.12. The process as claimed in claim 11 , wherein the catalyst used is either unsupported or supported.13. The process as claimed in claim 1 , wherein step a) or step b) or both are carried out in the presence of pure oxygen.14. The process as claimed in claim 1 , wherein the process is continuous.15. The process as claimed in claim 1 , wherein the inert gas is nitrogen claim 1 , helium and argon.16. The process as claimed in claim 1 , wherein the process is carried out at a temperature in the range of 300° C. to 400° C.17. The process as claimed in claim 1 , ...

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Номер записи: 36
25-05-2017 дата публикации

PROTIC-SOLUBLE ORGANIC ELECTROCHROMIC COMPOUNDS

Номер: US20170146880A1
Автор: Baumann Kelvin L., Franz Sue, GIRI PUNAM, LIN RONGGUANG
Принадлежит:

Protic-soluble electrochromic materials, ion-paired electrochromic materials including protic-soluble electrochromic materials, as well as electrochromic media and electrochromic devices incorporating such materials, are provided. The use of protic solvent mixtures, especially mixtures incorporating water, allows for the use of a wider variety of substrate materials. For example, plastics that may be soluble in organic aprotic solvent systems may be used in water-based devices. 2. The electrochromic medium of claim 1 , wherein in Formula (I){'sup': 1', '2', '−', '−', '−', '−, 'sub': 2', 'm', '2', '2', 'n', '2', 'p', '2', 'q', '2, 'Rand Rare each independently —(CH)—CO, —(CH)—P(O)(OH)(O), —(CH)—OP(O)(OH)(O), or —(CH)—S(O)O; and'}m, n, p, and q are each independently 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.3. The electrochromic medium of claim 1 , wherein in Formula (II){'sup': 12', '21', '−', '−', '−', '−, 'sub': 2', 's', '2', '2', 't', '2', 'u', '2', 'w', '2, 'Rand Rare each independently —(CH)—CO, —(CH)—P(O)(OH)(O), —(CH)—OP(O)(OH)(O), or —(CH)—S(O)O; and'}s, t, u, and w are each independently 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.4. The electrochromic medium of claim 1 , wherein in Formula (III){'sup': 23', '28', '−', '−', '−', '−, 'sub': 2', 'm′', '2', '2', 'n′', '2', 'p′', '2', 'q′', '2, 'Rand Rare each independently alkyl, —(CH)—CO, —(CH)—P(O)(OH)(O), —(CH)—OP(O)(OH)(O), or —(CH)—S(O)O; and'}m′, n′, p′, and q′ are each independently 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.8. The electrochromic medium of claim 1 , wherein the protic solvent comprises an alcohol claim 1 , a carboxylic acid claim 1 , a primary amino compound claim 1 , a secondary amino compound claim 1 , water claim 1 , or a mixture of any two or more thereof.9. The electrochromic medium of claim 1 , wherein the protic solvent comprises methanol claim 1 , ethanol claim 1 , isopropanol claim 1 , trifluoroethanol claim 1 , butanol claim 1 , ethylene glycol claim 1 , propylene glycol claim 1 , water claim 1 , or a ...

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Номер записи: 37
18-06-2015 дата публикации

REGENERATION OF ACIDIC IONIC LIQUID CATALYSTS

Номер: US20150165430A1
Автор: Elomari Saleh Ali, Harris Thomas Van
Принадлежит:

We provide a process for regenerating a used acidic ionic liquid catalyst which has been deactivated by conjunct polymers in a reactor, by removing at least 57 wt % of the conjunct polymers originally present in the used acidic ionic liquid catalyst in a separate regeneration reactor, so as to increase the activity of the catalyst. We also provide a regenerated used acidic ionic liquid catalyst having increased activity. 1. A process for regenerating a used acidic ionic liquid catalyst which has been deactivated by conjunct polymers in a reactor , comprising removing conjunct polymers originally present in the used acidic ionic liquid catalyst in a separate regeneration reactor , so as to increase an activity of the used acidic ionic liquid catalyst.2. The process according to claim 1 , wherein at least 57 wt % of the conjunct polymers originally present in the used acidic ionic liquid catalyst are removed.3. The process according to claim 2 , wherein greater than 90 wt % of the conjunct polymers originally present in the used acidic ionic liquid catalyst are removed.4. The process according to claim 2 , wherein up to 98.4 wt % of the conjunct polymers originally present in the used acidic ionic liquid catalyst are removed.5. The process according to claim 1 , wherein the used acidic ionic liquid catalyst has been used to catalyze a Friedel-Craft reaction.6. The process according to claim 1 , wherein the used acidic ionic liquid catalyst comprises an imidazolium claim 1 , pyridinium claim 1 , phosphonium or tetralkylammonium derivative claim 1 , or their mixtures.7. The process according to claim 1 , wherein the used acidic ionic liquid catalyst is a chloroaluminate ionic liquid.8. The process according to claim 1 , wherein the removing of the conjunct polymers produces a regenerated ionic liquid catalyst having better activity than a fresh ionic liquid catalyst from which the used acidic ionic liquid catalyst was made.9. The process according to claim 1 , wherein ...

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Номер записи: 38
08-06-2017 дата публикации

Method For Preparation of Alkylated or Fluoro, Chloro and Fluorochloro Alkylated Compounds By Heterogeneous Catalysis

Номер: US20170158695A1
Автор: Beller Matthias, Ellinger Stefan, He Lin, Natte Kishore, NEUMANN Helfried, Taeschler Christoph, Zaragoza Doerwald Florencio
Принадлежит:

The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous Pt/C-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of CsC0or CsHC0. 116-. (canceled)19. The method according to claim 17 , whereinm, n and q are identical or different and independently from each other 0, 1, 2, 3 or 4.21. The method according to claim 17 , whereinX is Br or I.22. The method according to claim 17 , whereinX is I.23. The method according to claim 17 , wherein{'sub': 2', '2, 'compound FCLALKYLHADLIDE is a perfluoroalkyl halide, FHC—Cl or FHC—Br.'}24. The method according to claim 17 , whereinX is Cl, Br or I, and{'sub': '1-20', 'R3 is perfluoro Calkyl; or'}{'sub': 2', '2, 'FCLALKYLHADLIDE is FHC—Cl or FHC—Br.'}25. The method according to claim 17 , wherein{'sub': 21', '10', '17', '8', '13', '6', '9', '4', '3', '3', '3', '2', '2, 'FCLALKYLHALIDE is selected from the group consisting of FC—I, FC—I, FC—I, FC—I, FC—I, FC—Br, FC—Cl, FHC—Cl and FHC—Br.'}26. The method according to claim 17 , whereinthe reaction is done in the presence of a compound COMPSALT;wherein COMPSALT is selected from the group consisting of NaI, KI, CsI and N(R30)(R31)(R32)R33I; and{'sub': '1-10', 'R30, R31, R32 and R33 are identical or different and independently from each other selected from the group consisting of H and Calkyl.'}27. The method according to claim 26 , wherein{'sub': '2-6', 'R30, R31, R32 and R33 are identical or different and independently from each other selected from the group consisting of H and Calkyl.'}28. The method according to claim 26 , wherein{'sub': '4', 'COMPSALT is selected from the group consisting of NaI and (n-Bu)NI.'}29. The method according to claim 17 , whereinthe amount of Pt in CAT is from 0.1 to 20%, the % are % by weight and are based on the combined weight of Pt and C in CAT.30. The method according ...

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Номер записи: 39
24-06-2021 дата публикации

PROCESS FOR THE HALOGENATION AT THE ALPHA-H POSITION OF ALKYLARENES VARIOUSLY SUBSTITUTED ON THE AROMATIC RING

Номер: US20210188733A1
Автор: DE LUCA Lidia Vera Giovanna, GASPA Silvia, Mulas Gabriele, PORCHEDDU Andrea, VALENTONI Antonio
Принадлежит:

A process that allows halogenation at the alpha-H position of alkylarenes, optionally further substituted on the aromatic or heteroaromatic ring, is described. 1. A process for the preparation of alkylarenes selectively halogenated on the carbon atom of the alkyl substituent directly bonded to the aromatic or heteroaromatic ring by reaction of the respective non-halogenated alkylarene compound exclusively with trichloroisocyanuric acid in the presence of irradiation with visible light , in the total absence of solvents and any metal catalysts or chemical additives.2. The process according to claim 1 , wherein alkylarenes are compounds consisting of an aromatic or heteroaromatic ring having at least one alkyl chain as a substituent.3. The process according to claim 1 , wherein said aromatic or heteroaromatic ring is selected from: benzene claim 1 , pyridine claim 1 , quinoline claim 1 , isoquinoline claim 1 , and alkyl is a linear or branched alkyl having from 1 to 5 carbon atoms.4. The process according to claim 1 , wherein said aromatic or heteroaromatic ring is further substituted with one or more substituents selected from: CH claim 1 , C(CH) claim 1 , Cl claim 1 , CN claim 1 , NO claim 1 , F claim 1 , phenyl.5. The process according to claim 1 , wherein the starting products: alkylarene/trichloroisocyanuric acid are in a stoichiometric ratio of between 4:2 and 2:0.5 claim 1 , preferably 3:1.6. The process according to claim 1 , wherein the starting products are reacted under solar light irradiation for a time of between 5 minutes and 12 hours at a temperature between 20 and 35° C. claim 1 , and under an inert atmosphere.7. The process according to claim 6 , wherein the irradiation is carried out with a solar simulator claim 6 , or tungsten lamp claim 6 , or blue led claim 6 , or by simply exposing the reaction reactor to the sun.8. The process according to claim 1 , wherein the final product is isolated by filtration through a silica pad.9. The process according ...

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Номер записи: 40
21-05-2020 дата публикации

Method for Preparation of Alkylated or Fluoro, Chloro and Fluorochloro Alkylated Compounds by Heterogeneous Cobalt Catalysis

Номер: US20200157063A1
Автор: Beller Matthias, Ellinger Stefan, FISCHER Florian, NEUMANN Helfried, Taeschler Christoph, Zaragoza Doerwald Florencio
Принадлежит:

The invention discloses a method for preparation of alkylated, fluoro alkylated, chloro alkylated and fluorochloro alkylated compounds by a heterogeneous Co-catalysed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides, fluoro alkyl halides, chloro alkyl halides or fluorochloro alkyl halides respectively. 2. The method according to claim 1 , whereinwhen RINGA is a heterocyclic ring, then RINGA has 1, 2 or 3 identical or different endocyclic heteroatoms independently from each other selected from the group consisting of N and S.3. The method according to claim 1 , wherein RINGA is an aromatic ring.6. The method according to claim 1 , wherein m claim 1 , n claim 1 , p and q are identical or different and independently from each other 0 claim 1 , 1 claim 1 , 2 claim 1 , 3 or 4.7. The method according to claim 1 , wherein{'sub': 2-6', '1-6', '1-6', '1-6, 'Y1, Y2 and R13 are identical or different and independently from each other selected from the group consisting of H, OH, C(R14)(R15)R16, Calkyl, O—Calkyl, phenyl, benzyl, O-phenyl, O—Calkylen-O—Calkyl and N(R19)R20.'}10. The method according to claim 1 , wherein R3 is Calkyl claim 1 , wherein all hydrogen atoms are independently substituted by Cl or F.11. The method according to claim 1 , wherein R3 is Calkyl claim 1 , wherein all hydrogen atoms are substituted by F.12. The method according to claim 1 , wherein ALKHAL is selected from the group consisting of FC—I claim 1 , FC—I claim 1 , FC—I claim 1 , FC—I claim 1 , FC—I claim 1 , FC—Br claim 1 , FC—Br claim 1 , FC—Br claim 1 , FC—Br claim 1 , FC—Br claim 1 , FC—Cl claim 1 , FHC—Cl claim 1 , and FHC—Br.13. The method according to claim 1 , wherein Co-L1/C is prepared by reacting Co(OAc).4HO with 1 claim 1 ,10-phenantroline and thereby forming a complex Co (phen)(OAc)which is then absorbed on carbon black and kept at 800° C. for 2 h under argon to provide Co-L1/C. The invention discloses a method for preparation of alkylated, fluoro alkylated, ...

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Номер записи: 41
18-09-2014 дата публикации

PROCESSES FOR PREPARING N-ETHYL-2-METHYLPYRIDINIUM BROMIDE AND N-ETHYL-3-METHYLPYRIDINIUM BROMIDE

Номер: US20140262818A1
Автор: BEN-DAVID Iris, KOMPANIETS Igor, MIASKOVSKI Gershon
Принадлежит: Bromine Compounds Ltd.

A process for preparing an aqueous solution of N-ethyl-2-methylpyridinium bromide (2-MEPy), comprising reacting 2-picoline and ethyl bromide in a pressure reactor at a temperature above the melting point of the reaction mixture, combining the reaction product with water, wherein said reaction product consists essentially of 2-MEPy in a liquid form, and recovering an aqueous solution of 2-MEPy. 1. A process for preparing an aqueous solution of N-ethyl-2-methylpyridinium bromide (2-MEPy) , comprising reacting 2-picoline and ethyl bromide in a pressure reactor at a temperature above the melting point of the reaction mixture , combining the reaction product with water , wherein said reaction product consists essentially of 2-MEPy in a liquid form , and recovering an aqueous solution of 2-MEPy.2. A process according to claim 1 , wherein the reaction is carried out at a temperature above 90° C.3. A process according to claim 2 , comprising charging a pressure reactor with 2-picoline claim 2 , sealing and heating the reactor claim 2 , gradually feeding ethyl bromide in an excess of from 1 to 10 molar % claim 2 , allowing the reaction to reach completion at a temperature above 95° C. to form a reaction product consisting essentially of 2-MEPy in a liquid form claim 2 , and combining the liquid reaction product with water.4. A process for preparing an aqueous solution of N-ethyl-2-methylpyridinium bromide (2-MEPy) or N-ethyl-3-methylpyridinium bromide (3-MEPy) claim 2 , comprising reacting in an aqueous medium ethyl bromide with 2-picoline or 3-picoline claim 2 , respectively.5. A concentrated aqueous solution of 2-MEPy claim 2 , 3-MEPy or a mixture thereof claim 2 , wherein the concentration of the solution is from 40 wt % to 92 wt %.6. A concentrated aqueous solution according to claim 5 , wherein the concentration of the solution is from 65 wt % to 90 wt %.7. A concentrated aqueous solution according to claim 5 , wherein either 2-MEPy or 3-MEPy was isolated in a non-solid ...

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Номер записи: 42
30-06-2016 дата публикации

One-Component Reagent for the Fluoroalkylation Reaction

Номер: US20160185691A1
Автор: Fier Patrick, Hartwig John F., Morimoto Hiroyuki
Принадлежит: The Board of Trustees of the University of lllinois

A composition, consisting essentially of copper, a fluoroalkyl group, and a ligand comprising at least one group-V donor. The molar ratio of copper to the fluoroalkyl group is approximately 1. 1. A composition , consisting essentially of:copper,a fluoroalkyl group, anda ligand comprising at least one group-V donor;where the molar ratio of copper to the fluoroalkyl group is approximately 1.3. The composition of claim 2 , where the fluoroalkyl group is selected from the group consisting of —CF claim 2 , —CFCF claim 2 , —CHCF claim 2 , —CHCHF claim 2 , —CFCFCF claim 2 , —CHCFCF claim 2 , —CHCHCF claim 2 , —CHCHCHF claim 2 , —CH(CF)and —CF(CF).4. The composition of claim 1 , where the ligand is selected from the group consisting of a phenanthroline claim 1 , an N claim 1 ,N′-disubstituted diamine claim 1 , a bipyridyl claim 1 , a pyridyl claim 1 , a phosphine claim 1 , and a phosphite.5. The composition of claim 1 , where the ligand is selected from the group consisting of 1 claim 1 ,10-phenanthroline (phen) claim 1 , bipyridyl (bipy) claim 1 , pyridyl (Py) claim 1 , tetramethylenediamine (TMEDA) claim 1 , N claim 1 ,N′-dimethylethylenediamine (DMEDA) claim 1 , N claim 1 ,N′-dimethyl-cyclohexanediamine (DMECA) claim 1 , tributyl phosphine [(n-Bu)P] claim 1 , triphenyl phosphine (PhP) claim 1 , trimethyl phosphite [(MeO)P] and triphenyl phosphite [(PhO)P].6. The composition of claim 1 , where the ligand is 1 claim 1 ,10-phenanthroline and the fluoroalkyl group is —CF.7. The composition of claim 1 , where the ligand is 1 claim 1 ,10-phenanthroline and the fluoroalkyl group is —CFCFCF.8. A composition claim 1 , consisting essentially of:copper,a fluoroalkyl group,a first ligand comprising at least one group-V donor, anda second ligand, different from the first ligand;where the molar ratio of copper to the fluoroalkyl group is approximately 1.9. The composition of claim 8 , where the second ligand comprises at least one of a group-V donor and a group-VI donor.10. The ...

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Номер записи: 43
06-07-2017 дата публикации

TRANSPARENT DISPLAY DEVICE

Номер: US20170192334A1
Автор: AN Hyun Jin, JUNG Jin Hyun, Kim Jong Moo
Принадлежит:

Disclosed is a transparent display device including an electrochromic element. The electrochromic element includes an electrochromic layer, a counter layer, and an electrolyte layer. An image is displayed through an oxidation-reduction reaction, and the display device is in a transparent mode when a voltage is not applied. The electrochromic layer and the counter layer may further include a core material for changing a color at a high speed. 1. A transparent display device comprising:a first substrate and a second substrate facing each other;a thin film transistor (TFT) disposed on one surface of the first substrate;a first transparent electrode connected to the TFT;a second transparent electrode disposed on the second substrate to face the first substrate; andan electrochromic element provided between the first transparent electrode and the second transparent electrode.2. The transparent display device of claim 1 , whereinthe TFT comprises a source electrode and a passivation layer disposed on the source electrode, andthe source electrode transfers an electrical signal to the first transparent electrode through a contact hole included in the passivation layer.3. The transparent display device of claim 1 , wherein the electrochromic element comprises:an electrochromic layer provided on the first transparent electrode;a counter layer provided on the second transparent electrode to face the first substrate; andan electrolyte layer disposed between the electrochromic layer and the counter layer.4. The transparent display device of claim 3 , wherein the electrochromic layer comprises one of a material emitting red light claim 3 , a material emitting green light claim 3 , and a material emitting blue light.6. The transparent display device of claim 5 , wherein the hydrocarbon is substituted by a group selected from aryl groups claim 5 , halogen claim 5 , nitrogen claim 5 , oxygen claim 5 , alcohols claim 5 , esters claim 5 , ammonium salts claim 5 , or phosphonium salts. ...

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Номер записи: 44
22-07-2021 дата публикации

Mixed-Valence Crystal Superstructures

Номер: US20210221811A1
Автор: Liu Zhichang, Stoddart James Fraser
Принадлежит:

Disclosed herein is a mixed-valence crystal superstructure assembled from a host-guest inclusion complex. The complex comprises an aromatic guest encircled by two macrocycles, wherein the complex has an empirical charge greater than 0 and less than 1. Methods of preparing the compositions described herein are also disclosed. 1. A mixed-valence host-guest inclusion complex comprising an aromatic guest encircled by two macrocycles , wherein the complex has an empirical charge greater than 0 and less than 1.3. The complex of claim 2 , wherein the aromatic guest comprises methyl viologen.4. The complex of claim 1 , wherein each of the two macrocycles encircling the aromatic guest comprise cyclobis(paraquat-p-phenylene.5. The complex of claim 4 , wherein the complex has an empirical formula of [MV⊂(CBPQT)].6. A mixed-valence superstructure comprising an ordered arrangement of a multiplicity of complexes as in and a counter anion.7. The superstructure of claim 6 , wherein the superstructure comprises an octahedral arrangement of the multiplicity of complexes.8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. The superstructure of claim 6 , wherein the superstructure has an empirical formula of [MV⊂(CBPQT)]·(PF).13. A crystalline composition comprising an ordered arrangement of a plurality of superstructures as in .14. The composition of claim 13 , wherein the composition comprises a body-centered cubic arrangement of the plurality of superstructures.15. The composition of claim 13 , wherein the ordered arrangement results in channels.16. The composition of claim 15 , wherein the composition comprises the counter anion disposed within the channels.17. (canceled)18. (canceled)19. (canceled)20. (canceled)21. The composition of claim 13 , wherein the composition has an empirical formula of [MV⊂(CBPQT)]·(PF).22. The composition of claim 13 , wherein the composition has a molecular packing arrangement defined by space group R.23. The composition of claim 13 , wherein the ...

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Номер записи: 45
14-07-2016 дата публикации

LIQUID CRYSTAL COMPOUND HAVING TETRAFLUORO CYCLOHEXADIENE STRUCTURE SHOWING NEGATIVE ANISOTROPY, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE

Номер: US20160200980A1
Автор: YANO Tomohiro
Принадлежит:

A liquid crystal compound is represented by the formula (1). For example, in the formula (1): Rand Reach represent an alkyl having 1 to 10 carbon atoms, an alkenyl having 2 to 10 carbon atoms, or an alkoxy having 1 to 9 carbon atoms; a ring Aand a ring Aeach represent 1,4-cyclohexylene or 1,4-phenylene; Zand Zeach represent a single bond, —(CH)—, —CH═CH—, —COO—, —OCO—, —CFO—, —OCF—, —CHO—, or —OCH—; and a and b each represent 0, 1, 2, or 3 and the sum of a and b is 4 or less.

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Номер записи: 46
12-07-2018 дата публикации

Method for preparing pentachloropyridine by utiilizing dctf rectifying short steaming residues

Номер: US20180194728A1
Автор: Cheng Ding, Denghao Min, Huaihong Zhang, Xuemei Zhu, Zhaosheng Cai
Принадлежит: Yancheng Institute of Technology

A method for preparing pentachloropyridine by utilizing DCTF rectifying short steaming residues, comprising the following steps: converting polymers in the residues through in situ catalytic cracking and vacuum distillation by using the catalytic degradation function of a catalyst formed by aluminum oxide, silicon oxide, zirconia, 4A zeolite, magnesium oxide, mordenite and HZSM-5 zeolite on the polymers in the DCTF rectifying short steaming residues into small molecular compounds and obtaining pentachloropyridine-containing crude oil; washing the pentachloropyridine-containing crude oil by using an aqueous solution of an alkaline assistant formed by sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, ammonium bicarbonate and sodium hydroxide, carrying out reduced pressure rectification, refrigerating crystallization, vacuum filtration or centrifuging separation, solvent washing, and vacuum drying method sequentially to obtain a pentachloropyridine product with a mass percentage content greater than 95% at a yield being 1-15% of the mass of the DCTF rectifying short steaming residues.

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Номер записи: 47
12-07-2018 дата публикации

ELECTROCHROMIC COMPOUNDS AND OPTICAL ARTICLES CONTAINING THEM

Номер: US20180194995A1
Автор: AIKEN Stuart, Archambeau Samuel, Berit-Debat Fabien, Biver Claudine, BROADBENT Thomas David, GABBUTT Christopher David, HERON Bernard Mark
Принадлежит: Essilor International

Electrochromic compounds and optical articles containing them The present invention relates to a group of novel electrochromic compounds. More specifically, it relates to electrochromic compounds comprising one or several pyridinium rings and the use of these compounds as a variable transmittance medium for the manufacture of an optical article, such as an ophthalmic lens. 2. The compound according to claim 1 , wherein Z is an unsubstituted phenylene or an unsubstituted naphtylene selected from the group consisting of:ortho-branched phenylene,para-branched phenylene; and2,6-branched naphthylene.3. The compound according to claim 1 , wherein Z is a 2 claim 1 ,3 branched pyridinediyl radical.4. The compound according to claim 1 , wherein Z is a pyridiniumyl radical selected from the group consisting of:1,2-branched pyridiniumyl radical, preferably substituted by at least one aryl group;1,4-branched pyridiniumyl radical substituted or fused with at least one bicyclic system, preferably substituted by at least one aryl group, a N-alkylpyridinium group or fused with at least one 1,2,3,4-tetrahydronaphthalene system;3,4 branched pyridiniumyl radical; and3,5 branched pyridiniumyl radical.5. The compound according to claim 1 , wherein Y is N or (N—R)(X) where Ris a C-Calkyl claim 1 , a N—C-Calkylpyridinium or a phenyl.6. The compound according to claim 1 , wherein each one of R-Ris H.7. The compound according to claim 1 , wherein Y is N and n is equal to 1 or wherein Y is (N—R)(X) and n is equal to 2 claim 1 , 3 or 4.8. The compound according to claim 1 , wherein the counterion Xis selected from the group consisting of halide claim 1 , tetrafluoroborate claim 1 , tetraphenylborate claim 1 , hexafluorophosphate claim 1 , nitrate claim 1 , methanesulfonate claim 1 , trifluoromethane sulfonate claim 1 , toluene sulfonate claim 1 , hexachloroantimonate claim 1 , bis(trifluoromethanesulfonyl)imide claim 1 , perchlorate claim 1 , acetate and sulfate.10. The compound according to ...

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Номер записи: 48
30-07-2015 дата публикации

COMPOUND FOR THE TREATMENT OF TUMOURS AND TUMOUR METASTASES

Номер: US20150210669A1
Автор: Bellini Marta, Betti Matteo, Minetto Giacomo, Pericot Mohr Gal.la, Thomas Russel J., Wiedenau Paul H.
Принадлежит: Siena Biotech S.p.A.

The invention relates to a Smoothened receptor ligand which antagonises the Hedgehog pathway, to pharmaceutical compositions and therapeutic applications thereof, processes for obtaining this compound and novel intermediates useful in these processes. 2. The compound of for use as a medicament.3. The compound of for use in the treatment of cancer claim 1 , wherein said cancer is selected from the list of: non-small cell lung carcinoma; small-cell lung cancer; breast cancer; ovarian tumours; digestive tract tumours; brain cancers; prostate cancer; pancreatic cancer; basal cell carcinoma; Gorlin syndrome; malignant melanoma; squamous cell carcinomas; multiple myeloma; lymphoma; mesenchymal cancers; chronic myeloid leukaemia; endometrial carcinoma; hepatocellular carcinoma.4. The compound of for use in the treatment of brain cancers.5. The compound of for use in the treatment of cancer metastases in the brain.6. The compound of for use in the treatment of a cancer that metastasises to the brain.7. The compound of for use as a Smo receptor antagonist.8. Method of treating cancer with a medicament comprising the compound of claim 1 , said method comprising administering to a patient in need thereof an effective amount of the compound of and treating said patient of said cancer.12. The method of claim 10 , wherein LG is a linear branched or cyclic Calkoxy group.14. Method of preparing the compound of with the compound of as an intermediate or starting material.15. The method of claim 8 , wherein said effective amount ranges from 0.01 to 200 mg/kg. The invention relates to a novel, brain penetrant, Smoothened receptor ligand which antagonises the Hedgehog pathway, to its pharmaceutical applications, to processes for obtaining this compound and to novel intermediates useful in these processes.The inhibition of Hedgehog pathway by Smoothened receptor (Smo) antagonists is now a well known approach to treat a variety of cancer types: compounds known as GDC449, LDE225, IP1926 ...

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Номер записи: 49
28-07-2016 дата публикации

METALLOTRIANGLE-BASED NANOMOLECULES AND METHODS OF MAKING THE SAME

Номер: US20160214938A1
Автор: Moorefield Charles N., Newkome George R.
Принадлежит:

Metallotriangle-based nanomolecules are formed by a one-step self-assembly of specifically chosen shaped poly-ligand monomers, the poly-ligand monomers coordinating with metal ions through coordinating ligands. The poly-ligand monomers are defined by vertex groups having arms extending therefrom and ending in coordinating ligands. Based on the desired metallotriangle-based nanomolecule structure to be assembled, specifically shaped poly-ligand monomers and metal ions are chosen and mixed in appropriate ratios so that coordinating ligands bind to metal ions and the poly-ligand monomers thus spontaneously self-assemble into the desired metallotriangle-based nanomolecule structure. 1. A method of preparing a metallotriangle-based nanomolecule comprising the steps of: (a) the V-shaped monomers include a cyclic V-vertex group with first and second coordinating V-arms extending from the cyclic V-vertex group at 60° from one another, each of the first and second coordinating Y-arms terminating in a metal-coordinating V-ligand;', '(b) the wide V-shaped a cyclic wide V-vertex group with first and second coordinating wide V-arms extending from the cyclic wide V-vertex group at 120° from one another, each of the first and second coordinating wide V-arms terminating in a metal-coordinating wide V-ligand', '(c) the X-shaped monomers include a cyclic X-vertex group with first and second coordinating X-arms extending from the cyclic X-vertex group at 60° from one another, and opposed third and fourth coordinating X-arms extending from the cyclic X-vertex group at 60° from one another in a direction opposite to the first and second coordinating X-arms, each of the first, second, third, and fourth coordinating X-arms terminating in a metal-coordinating X-ligand;', '(d) the unsymmetrical Y-shaped monomers include a cyclic unsymmetrical Y-vertex group with first and second coordinating unsymmetrical Y-arms extending from the cyclic unsymmetrical Y-vertex group at 180° from one another ...

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Номер записи: 50
28-07-2016 дата публикации

FLUORINE-CONTAINING COMPLEX COMPOUND, AND PRODUCTION METHOD FOR FLUORINE-CONTAINING ORGANIC COMPOUND EMPLOYING SAME

Номер: US20160214999A1
Автор: Adachi Kenji, NAGAI Takabumi, OGOSHI Sensuke, OHASHI Masato, Shibanuma Takashi
Принадлежит:

An object of the present invention is to enable the synthesis of various fluorine-containing compounds having an organic group at both terminals of their tetrafluoroethylene structure (—CF—CF—). The present invention provides a fluorine-containing complex compound including 3. A method for producing a fluorine-containing compound represented by formula (4):{'br': None, 'sup': 2', '1, 'sub': 2', '2, 'R—CF—CF—R\u2003\u2003(4)'}{'sup': 1', '2, 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'wherein Ris as defined in ; and Rrepresents an organic group,'}{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'claim-text': {'br': None, 'sup': '2', 'X—R\u2003\u2003(5)'}, 'the method comprising step B of reacting the fluorine-containing complex compound according to with a halogen compound represented by formula (5){'sup': '2', 'wherein Ris as defined above; and X represents a halogen atom.'} The present invention relates to a fluorine-containing complex compound and a method for producing a fluorine-containing organic compound using the fluorine-containing complex compound.Fluorine-containing organic compounds have very unique properties distinguished from other compounds and due to, for example, the energy scale of the C—F bond, the low polarization of the C—F bond, and the dipole moment of the C—F bond. Because of their unique properties, fluorine-containing organic compounds have a considerably wide range of applications, for example, in resin, rubber, coating compositions, film, water repellents, oil repellents, liquid crystals, dyes, physiologically active substances, and starting materials of these materials, depending on their structure and characteristics.Tremendous efforts have thus been made in the development of synthesis methods for a variety of fluorine-containing organic compounds.Of fluorine-containing organic compounds, compounds having an organic group at both terminals of their tetrafluoroethylene structure (—CF—CF—) (this structure may be may be referred to ...

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Номер записи: 51
27-07-2017 дата публикации

Silicon-based cross coupling agents and methods of their use

Номер: US20170210766A1
Автор: Adam T. HOYE, Amos B. Smith, Bruno Nicolas MELILLO, Dionicio MARTINEZ-SOLORIO, Luis Sanchez, Minh Huu Nguyen, Rongbiao TONG, Won-Suk Kim
Принадлежит: University of Pennsylvania Penn

Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.

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Номер записи: 52
04-08-2016 дата публикации

ELECTROCHROMIC TWO-CORE VIOLOGEN DERIVATIVES AND OPTICAL ARTICLES CONTAINING THEM

Номер: US20160221949A1
Автор: AIKEN Stuart, Archambeau Samuel, Berit-Debat Fabien, Biver Claudine, Crossley Daniel Luke, GABBUTT Christopher David, HERON Bernard Mark
Принадлежит: Essilor International (Compagnie Generale d'Optiqu e)

The present invention relates to a group of novel electrochromic materials. More specifically, it relates to electrochromic materials having two-core viologens and the use of these two-core viologens as a variable transmittance medium for the manufacture of an optical article, such as an ophthalmic lens. 118.-. (canceled)21. The compound according to claim 19 , wherein A and B are respectively selected from nitrogen and —N(R)— claim 19 , and from nitrogen and —N(R)— claim 19 , wherein Rand Rare independently selected from C-Calkyl claim 19 , phenyl and naphthyl which may be both substituted by one or more substituents selected from halogen claim 19 , cyano claim 19 , nitro claim 19 , hydroxy claim 19 , C-Calkyl claim 19 , C-Chaloalkyl claim 19 , C-Calkoxy claim 19 , C-Chaloalkoxy claim 19 , C-Calkylthio claim 19 , C-Chaloalkylthio claim 19 , C-Ccycloalkyl claim 19 , (C-Ccycloalkyl)C-Calkyl.22. The compound according to claim 19 , wherein the counterion X is selected from halide claim 19 , tetrafluoroborate claim 19 , tetraphenylborate claim 19 , hexafluorophosphate claim 19 , nitrate claim 19 , methanesulfonate claim 19 , trifluoromethane sulfonate claim 19 , toluene sulfonate claim 19 , hexachloroantimonate claim 19 , bis(trifluoromethanesulfonyl)imide claim 19 , perchlorate claim 19 , acetate and sulfate.24. The compound according to claim 23 , wherein Rand Rare each independently selected from phenyl claim 23 , m-methylphenyl and p-trifluoromethylphenyl and are preferably identical.27. An electrochromic composition comprising at least one compound as defined in .28. The electrochromic composition according to claim 27 , wherein said composition comprises a fluid claim 27 , mesomorphous or gel host medium.29. The electrochromic composition according to claim 28 , wherein the fluid or mesomorphous host medium is selected from the group consisting of organic solvents claim 28 , liquid crystals claim 28 , polymers claim 28 , liquid crystal polymers and mixtures ...

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Номер записи: 53
04-08-2016 дата публикации

ESTER NITRATES DERIVATIVES OF AROMATIC ALDEHYDES WITH MULTIPLE PHARMALOGIC PROPERTIES TO TREAT SICKLE CELL DISEASE

Номер: US20160221978A1
Автор: DANSO-DANQUAH Richmond, DESPANDE Tanvi, Safo Martin, VENITZ Jurgen, Zhang Yan
Принадлежит:

The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention. 157-. (canceled)59. The compound according to claim 58 , wherein R1 is H; and M is O; and R2 is H; and R3 is OH; and p is 0; and salts thereof.64. A method for treating a subject having sickle cell disease (SCD) claim 58 , comprising administering to the subject a therapeutically effective amount of a compound according to .71. A method for treating a subject having sickle cell disease (SCD) claim 69 , comprising administering to the subject a therapeutically effective amount of a compound according to .74. The compound according to claim 73 , wherein R1 is H; and M is O; and R2 is H; and R3 is ONO; and p is 0; and salts thereof.78. A method for treating a subject having sickle cell disease (SCD) claim 73 , comprising administering to the subject a therapeutically effective amount of a compound according to . 1. Field of the InventionThe invention relates to aromatic aldehydes and their use in the treatment of Sickle Cell Disease.2. Summary of the Related ArtSickle cell disease (SCD) is the consequence of substitution of Glu by Val in the 6position of the β-globin chain of hemoglobin (Hb) resulting in the formation of sickle Hb (HbS). Intracellular polymerization of deoxygenated sickle Hb into long, rigid and insoluble fibres causes the pathophysiology associated with SCD; facilitating a cascade of adverse events that include decreased nitric oxide (NO) bioavailability, endothelial cell activation, compensatory vasoconstriction, increase in neutrophil count, adhesion of red blood cells (RBCs) to tissue endothelium, vaso-occlusion and impaired microvascular blood flow. The clinical condition is ...

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Номер записи: 54
04-08-2016 дата публикации

NOVEL CYTOCHROME P450 INHIBITORS AND THEIR METHOD OF USE

Номер: US20160221990A1
Автор: Abou-Gharbia Magid A, Blass Benjamin Eric, Boruwa Joshodeep, Childers Wayne e., IYER Pravin
Принадлежит:

Embodiments of the present invention relate to novel cytochrome P450 inhibitors and pharmaceutical compositions thereof having a disease-modifying action in the treatment of diseases associated with the production of cortisol that include metabolic syndrome, obesity, headache, depression, hypertension, diabetes mellitus, Cushing's Syndrome, pseudo-Cushing syndrome, cognitive impairment, dementia, heart failure, renal failure, psoriasis, glaucoma, cardiovascular disease, cancer, stroke or incidentalomas. 11. A compound selected from the group consisting of:(E)-1-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-yl)ethanone;(E)-1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(3-(trifluoromethoxy) phenylsulfonyl)piperazine;(E)-1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(3-chloropropyl sulfonyl)piperazine;(E)-3-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-ylsulfonyl)benzonitrile;(E)-1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(4-chloro-3-nitrophenylsulfonyl) piperazine;(E)-1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(3-nitrophenylsulfonyl)piperazine;(E)-1-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-hydroxystyryl)phenyl)piperazin-1-yl)ethanone;(E)-1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(1H-imidazol-4-ylsulfonyl)piperazine;(E)-1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl) phenyl)-4-(cyclopropylsulfonyl)piperazine;(E)-1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl) phenyl)-4-(ethylsulfonyl)piperazine;(E)-1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(isopropylsulfonyl)piperazine;(E)-1-(4-(4-(3-fluoro-5-(pyridin-4-yl)styryl)phenyl)piperazin-1-yl)ethanone;(E)-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-yl)(pyridin-3-yl)methanone;(E)-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-yl)(3-nitrophenyl)methanone;(E)-3-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazine-1- ...

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Номер записи: 55
03-08-2017 дата публикации

KCNQ2-5 CHANNEL ACTIVATOR

Номер: US20170217888A1
Автор: Saito Tetsuji, Wakamatsu Daisuke, Yashiro Kentaro
Принадлежит: ONO Pharmaceutical CO., Ltd

The present invention relates to a compound represented by the general formula (I) (wherein the definition of each group has the same meaning as described in the specification). The compound is useful as preventive and/or therapeutic agent for KCNQ2-5 channel-related diseases. 111-. (canceled)12. 1-[(5-chloro-2-pyridinyl)methyl]-3-{2 ,6-dichloro-4-[(2S)-1 ,1 ,1-trifluoro-2-hydroxy-2-propanyl]phenyl}urea , or a pharmaceutically acceptable salt thereof.1319.-. (canceled)20. 1-[(5-chloro-2-pyridinyl)methyl]-3-{2 ,6-dichloro-4-[(2S)-1 ,1 ,1-trifluoro-2-hydroxy-2-propanyl]phenyl}urea. The present invention relates to a compound represented by the general formula (I):(wherein all the symbols represent the same meanings as given below), a salt thereof, a solvate thereof, or a cocrystal thereof (hereinafter, also abbreviated as the compound of the present invention).It has been found that a KCNQ channel has five subtypes including KCNQ1, KCNQ2, KCNQ3, KCNQ4, and KCNQ5. Among them, KCNQs 2-5 other than KCNQ1 are expressed in the nociceptive sensory system such as spinal dorsal root ganglion and spinal cord. The activation of the KCNQ2-5 channel causes hyperpolarization of the nerve cell in a nociceptive signal pathway.It has been reported that KCNQ2-5 channel activator is useful for treatment for many disorders characterized by neuron excitatory disorders including epilepsy, pain, migraine, and anxiety disorders (see Non-Patent Literature 1). Actually, retigabine as a KCNQ2-5 channel activator has been marketed as an antiepileptic drug.Furthermore, in recent years, it has been also reported that the retigabine is useful for treatment for urinary bladder disorders (for example, overactive urinary bladder) (see Non-Patent Literatures 2 and 3).It is considered that since the overactive urinary bladder is caused by potential overactivity of the detrusor muscle, a muscarinic receptor antagonist having an effect of mainly inhibiting contraction of the urinary bladder has been ...

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Номер записи: 56
11-08-2016 дата публикации

ELECTROCHROMIC COMPOUNDS WITH IMPROVED COLOR STABILITY IN THEIR RADICAL STATES

Номер: US20160229803A1
Автор: Baumann Kelvin L., GIRI PUNAM, Kloeppner Leroy J., LIN RONGGUANG, Nemes Joel C., Theiste David A.
Принадлежит:

The invention relates to an electrochromic device and uses thereof, wherein the electrochromic device includes an electrochromic compound with reduced intermolecular interactions resulting in uncontrolled color changes represented by Formula (I): 2. The electrochromic device of claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , and Rare individually secondary alkyl claim 1 , tertiary alkyl claim 1 , or aryl.3. The electrochromic device of claim 1 , wherein Rand Rare individually aryl.5. The electrochromic device of claim 4 , wherein R claim 4 , R claim 4 , R claim 4 , and Rare individually H or alkyl.6. The electrochromic device of claim 4 , wherein R claim 4 , R claim 4 , R claim 4 , and Rare H claim 4 , and Ris H claim 4 , methyl claim 4 , ethyl claim 4 , propyl claim 4 , iso-propyl claim 4 , butyl claim 4 , sec-butyl claim 4 , or tert-butyl.7. The electrochromic device of claim 4 , wherein Ris alkyl or siloxy alkyl.8. The electrochromic device of claim 4 , wherein Ris H claim 4 , methyl claim 4 , ethyl claim 4 , propyl claim 4 , iso-propyl claim 4 , butyl claim 4 , sec-butyl claim 4 , tert-butyl claim 4 , or —(CH)Si(OR) claim 4 , Ris H or alkyl claim 4 , and n is 1 to 10.9. The electrochromic device of claim 1 , wherein Rand Rare aryl and Rand Rare H.10. The electrochromic device of claim 1 , wherein Rand Rare individually aralkyl claim 1 , C-Calkyl or C-Chydroxyalkyl.12. The electrochromic device of claim 11 , wherein Ris (CH)or 1 claim 11 ,4-phenylene.13. The electrochromic device of claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , and Rare individually H claim 1 , OH claim 1 , or alkyl.14. The electrochromic device of claim 1 , wherein X is F claim 1 , Cl claim 1 , Br claim 1 , I claim 1 , BF claim 1 , PF claim 1 , SbF claim 1 , AsF claim 1 , ClO claim 1 , SOCF claim 1 , N(CN) claim 1 , N(CFSO) claim 1 , C(CFSO) claim 1 , N(SOCF) claim 1 , Al(OC(CF))or BAr claim 1 , wherein Ar is a aryl or fluorinated aryl group.15. The electrochromic device of further ...

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Номер записи: 57
11-08-2016 дата публикации

ELECTROCHROMIC SINGLE AND TWO-CORE VIOLOGENS AND OPTICAL ARTICLES CONTAINING THEM

Номер: US20160231635A1
Автор: AIKEN Stuart, Archambeau Samuel, Berit-Debat Fabien, Biver Claudine, Duluard Sandrine, GABBUTT Christopher David, HERON Bernard Mark
Принадлежит: Essilor International (Compagnie Generale D'Optique)

The present invention relates to a group of novel electrochromic materials. More specifically, it relates to electrochromic materials based on either single or two-core viologen systems and the use of these viologen systems as a variable transmittance medium for the manufacture of an optical article, such as an ophthalmic lens. 118.-. (canceled)21. The compound according to claim 19 , wherein R claim 19 , R claim 19 , Rand Rare each independently selected from C-Calkyl claim 19 , C-Calkoxycarbonyl claim 19 , alkanoyl claim 19 , aroyl claim 19 , aryl and heteroaryl claim 19 , wherein the aryl and heteroaryl may be substituted by one or more substituents selected from C-Calkyl and C-Chaloalkyl claim 19 , preferably claim 19 , R claim 19 , R claim 19 , Rand Rare each independently selected from methyl claim 19 , ethoxycarbonyl claim 19 , phenyl claim 19 , p-methylphenyl and p-trifluoromethylphenyl.22. The compound according to claim 19 , wherein the counterion X is selected from halide claim 19 , tetrafluoroborate claim 19 , tetraphenylborate claim 19 , hexafluorophosphate claim 19 , nitrate claim 19 , methanesulfonate claim 19 , trifluoromethane sulfonate claim 19 , toluene sulfonate claim 19 , hexachloroantimonate claim 19 , bis(trifluoromethanesulfonyl)imide claim 19 , perchlorate claim 19 , acetate and sulfate.23. The compound according to claim 19 , wherein R claim 19 , R claim 19 , R claim 19 , Rand Rare each independently selected from H claim 19 , cyano claim 19 , halogen claim 19 , nitro claim 19 , hydroxyl claim 19 , alkyl claim 19 , preferably C-Calkyl claim 19 , haloalkyl claim 19 , alkoxy claim 19 , haloalkoxy claim 19 , alkoxycarbonyl claim 19 , cycloalkyl claim 19 , allyl claim 19 , aryl and heteroaryl.24. The compound according to claim 19 , wherein Re is H and at least one of R claim 19 , R claim 19 , Rand Ris not H claim 19 , preferably at least one of Rand Ris not H.26. An electrochromic composition comprising at least one compound as defined in .27. ...

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Номер записи: 58
20-08-2015 дата публикации

FABRICATION AND FUNCTIONALIZATION OF A PURE NON-NOBLE METAL CATALYST STRUCTURE SHOWING TIME STABILITY FOR LARGE SCALE APPLICATIONS

Номер: US20150236353A1
Автор: BERK Dimitrios, Binny Dustin, MENDOZA GONZALEZ Norma-Yadira, Meunier Jean-Luc, PASCONE Pierre-Alexandre, Vasilica Pristavita Ramona
Принадлежит: The Royal Institution for the Advancement of Learning / McGill University

A pure and crystalline single-crystal nitrogen-functionalized graphene nano-flake powder comprising from 2 atomic % to at least 35 atomic % of total functionalized nitrogen within the graphene nano-flakes is disclosed. As well, the method of producing the nano-flakes that comprises injecting a carbon source into a thermal plasma system, dissociating the carbon source into carbon atomic species, transporting the carbon atomic species through a controlled nucleation zone to produce a crystalline graphene nano-flake structure, injecting the nitrogen source into the thermal plasma system dissociating the nitrogen source into nitrogen active species, and transporting the nitrogen atomic species to contact the crystalline graphene nano-flakes to produce the crystalline nitrogen-functionalized graphene nano-flakes is also disclosed. Finally, a multilayer composite comprising a carbon substrate and a layer of crystalline nitrogen-functionalized graphene nano-flakes is also described. 1. A single-crystal nitrogen-functionalized graphene nano-flake comprising from 2 atomic % to at least 35 atomic % of total functionalized nitrogen.2. The nano-flake of claim 1 , comprising from 5 atomic % to at least 35 atomic % of total functionalized nitrogen.3. The nano-flake of claim 1 , comprising 20 atomic % to at least 35 atomic % of total functionalized nitrogen.4. The nano-flake of claim 1 , further comprising a range of pyridinic nitrogen from 10% to at least 25% as a total % nitrogen of the graphene.5. The nano-flake of claim 1 , further comprising a range of pyrollic nitrogen from 10% to at least 28% as a total % nitrogen on the graphene nano-flake structures.6. The nano-flake of claim 1 , comprising a nitrogen-coordination metal selected from the group consisting of Fe claim 1 , Ni claim 1 , Co claim 1 , Ti claim 1 , V claim 1 , and combinations thereof.7. The nano-flake of claim 6 , wherein the nitrogen-coordination metal is Fe.8. The nano-flake of claim 1 , comprising a ...

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Номер записи: 59
09-08-2018 дата публикации

PROTIC-SOLUBLE ORGANIC ELECTROCHROMIC COMPOUNDS

Номер: US20180224706A1
Автор: Baumann Kelvin L., Franz Sue F., GIRI PUNAM, LIN RONGGUANG
Принадлежит: GENTEX CORPORATION

Protic-soluble electrochromic materials, ion-paired electrochromic materials including protic-soluble electrochromic materials, as well as electrochromic media and electrochromic devices incorporating such materials, are provided. The use of protic solvent mixtures, especially mixtures incorporating water, allows for the use of a wider variety of substrate materials. For example, plastics that may be soluble in organic aprotic solvent systems may be used in water-based devices. 2. An electrochromic medium comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'an ion-paired electrochromic material of ; and'}a liquid or gel that comprises a protic solvent.3. An electrochromic device comprising:{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, 'the electrochromic medium of ; and'}a chamber defined by a first conductive surface of first substrate, a second conductive surface of a second substrate, and a sealing member joining the first substrate to the second substrate,wherein the electrochromic medium is disposed within the chamber.5. An electrochromic medium comprising{'claim-ref': {'@idref': 'CLM-00004', 'claim 4'}, 'an ion-paired electrochromic material of ; and'}a liquid or gel that comprises a protic solvent.6. An electrochromic device comprising:{'claim-ref': {'@idref': 'CLM-00005', 'claim 5'}, 'the electrochromic medium of ; and'}a chamber defined by a first conductive surface of first substrate, a second conductive surface of a second substrate, and a sealing member joining the first substrate to the second substrate,wherein the electrochromic medium is disposed within the chamber. This application is a divisional of U.S. patent application Ser. No. 15/065,808, filed on Mar. 9, 2016, now U.S. Pat. No. 9,939,701, which claims the benefit of U.S. Provisional Patent Application No. 62/257,950, filed on Nov. 20, 2015, and U.S. Provisional Patent Application No. 62/258,051, filed on Nov. 20, 2015, the entire disclosures of which are incorporated herein by ...

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Номер записи: 60
19-08-2021 дата публикации

HYDROGENATION PROCESS

Номер: US20210253537A1
Автор: Collier Steven James, Gordon Paul, HAMLIN Michael David, POLLINGTON Steve, SWINNEY John
Принадлежит:

A process for the production of heterocyclic quaternary ammonium salts or hydroxides is disclosed. The process comprises a continuous hydrogenation step, in which an unsaturated heterocyclic amine is reacted with hydrogen to form a saturated heterocyclic amine; a first continuous N-alkylation step, in which the saturated heterocyclic amine is alkylated to produce an intermediate saturated heterocyclic amine having an increased degree of substitution compared to the saturated heterocyclic amine; and one or more further N-alkylation steps in which the intermediate saturated heterocyclic amine is N-alkylated to the heterocyclic quaternary ammonium salt or hydroxide. A process of producing a saturated heterocyclic amine is also disclosed. The process comprises reacting an unsaturated heterocyclic amine with hydrogen in a vapour phase reaction at a pressure of not more than 70 bar and a temperature in the range of from 150° C. to 350° C. A process of N-alkylating a saturated heterocyclic amine is also disclosed. The process comprises N-alkylating the saturated heterocyclic amine in a vapour phase reaction at a temperature of at least 2° C. 1. A process of N-alkylating a saturated heterocyclic amine , the process comprising N-alkylating the saturated heterocyclic amine in a vapour phase reaction at a temperature of at least 220° C.2. A process according to wherein the process comprises reacting the saturated heterocyclic amine with dimethyl ether.3. A process according to claim 2 , wherein the dimethyl ether is generated in situ by the etherification of methanol.4. A process according claim 3 , wherein the saturated heterocyclic amine and the method are fed to the process at a molar ratio of from at least 1 mole of alkanol per mole of saturated heterocyclic amine to not more than 20 moles of alkanol per mole of saturated heterocyclic amine.5. A process according claim 1 , wherein the pressure is in the range of from 1 bar to 100 bar.6. A process according to wherein the ...

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Номер записи: 61
27-08-2015 дата публикации

ONE POT SYNTHESIS OF 18F LABELEDTRIFLUOROMETHYLATED COMPOUNDS WITH DIFLUORO(IODO)METHANE

Номер: US20150239796A1
Автор: Rafique Waqas, Riss Patrick, Ruhl Thomas
Принадлежит:

The present invention relates to compositions and methods for the synthesis of F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents). 2. The method of claim 1 , wherein said temperature is between 50° C. and 750° C.3. The method of claim 2 , wherein said reaction temperature is 145° C.4. The method of claim 1 , wherein said incubation time is between 1 s and 5 h.5. The method of claim 4 , wherein said incubation time is 10 minutes.6. The method of claim 1 , wherein said copper source is a copper(I) source.7. The method of claim 6 , wherein said copper source is selected from CuBr claim 6 , Tetrakisacetonitrile copper(I) triflate and CuI.8. The method of claim 1 , wherein said solvent is a polar aprotic solvent.9. The method of claim 8 , wherein said polar aprotic solvent is selected from DMF claim 8 , acetonitrile claim 8 , and dialkyl ketone.10. The method of claim 1 , wherein said base is a metal carbonate and/or metal bicarbonate and cyptand.11. The method of claim 10 , wherein said base is selected from KHCOand crypt-222 claim 10 , CsCOand crypt-222 claim 10 , KCOand crypt-222 claim 10 , KCOand 18-Crown-6 claim 10 , a nonmetal carbonate claim 10 , a nonmetal bicarbonate claim 10 , and tetraethylammonium bicarbonate12. The method of claim 1 , wherein said ligand is an organic non- to low-nucleophilic amine or phosphazene.13. The method of claim 12 , wherein said ligand is selected from DBU claim 12 , TMEDA claim 12 , NEtand DIPEA.14. The method of claim 12 , wherein said ligand stabilized the copper mediate.15. The method of claim 12 , wherein said ligand is a base.16. The method of claim 1 , wherein said claim 1 , when F-fluoride ion is present claim 1 , the CFsubstituted compounds are also synthesized.17. A compound synthesized by the method of .18. A method of PET imagining claim ...

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Номер записи: 62
18-08-2016 дата публикации

PROCESS FOR THE SYNTHESIS OF FLUORALKYL SULFONATE SALTS

Номер: US20160237028A1
Автор: Monzani Cristiano, Tortelli Vito
Принадлежит:

A process for the preparation of the fluoroalkyl sulfonate salt of a nitrogen-based organic base said process comprising the step of reacting a fluoroalkyl sulfonyl halide with an organic base selected from the group consisting of tertiary amines, pyridines, amidines and guanidines. 1. A process for the preparation of the fluoroalkyl sulfonate salt of an organic base said process comprising the step of reacting a fluoroalkyl sulfonyl halide with an organic base selected from the group consisting of pyridines , amidines and guanidines.2. The process of wherein the fluoroalkyl sulfonyl halide is selected from the group consisting of the fluoroalkyl sulfonates of formula (I) RSOX claim 1 , wherein X is selected from F claim 1 , Cl and Br; and Ris selected from the group consisting of Cto Cstraight-chain claim 1 , branched or cyclic fluorinated alkyl or alkenyl claim 1 , optionally substituted and/or optionally comprising heteroatoms selected from the group consisting of O claim 1 , N and S in the chain.4. The process of claim 1 , wherein the fluoroalkyl sulfonyl halide is reacted with the organic base in the presence of an alcohol.5. The process of wherein the organic base is selected from the group consisting of pyridines and amidines.7. The process of claim 1 , wherein the fluoroalkyl sulfonyl halide is reacted with the organic base in the presence of water under basic conditions.8. The process of wherein the organic base is a guanidine. This application claims priority to European application No. 13187325.9, filed on Oct. 4, 2013; the whole content of this application is incorporated herein by reference for all purposes.The present invention relates to a process for the preparation of fluoroalkyl sulfonate salts of nitrogen-based organic bases.Ionic liquids are liquids composed of ions that are liquid at temperatures of 100° C. or below. The very low vapour pressure, high thermal stability, and tuneable miscibility with other liquid phases that characterizes ionic ...

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Номер записи: 63
16-08-2018 дата публикации

TRANSPARENT DISPLAY DEVICE

Номер: US20180231862A1
Автор: AN Hyun Jin, JUNG Jin Hyun, Kim Jong Moo
Принадлежит:

Disclosed is a transparent display device including an electrochromic element. The electrochromic element includes an electrochromic layer, a counter layer, and an electrolyte layer. An image is displayed through an oxidation-reduction reaction, and the display device is in a transparent mode when a voltage is not applied. The electrochromic layer and the counter layer may further include a core material for changing a color at a high speed. 116.-. (canceled)17. A transparent display device which operates in a transparent mode and a display mode , comprising:a first substrate and a second substrate facing each other;a first transparent electrode disposed on one surface of the first substrate;a second transparent electrode disposed on the second substrate to face the first substrate; andan electrochromic element provided between the first transparent electrode and the second transparent electrode.18. The transparent display device of claim 17 , wherein the electrochromic element has a color in the display mode and is transparently changed in the transparent mode.19. The transparent display device of claim 18 , wherein the electrochromic element has a transmittance of 50% or more in the transparent mode.20. The transparent display device of claim 17 , further comprising:a thin film transistor (TFT) disposed between the first substrate and the first transparent electrode,the TFT comprises a source electrode and a passivation layer disposed on the source electrode, andthe source electrode transfers an electrical signal to the first transparent electrode through a contact hole included in the passivation layer.21. The transparent display device of claim 17 , wherein the electrochromic element comprises:an electrochromic layer provided on the first transparent electrode;a counter layer provided on the second transparent electrode to face the first substrate; andan electrolyte layer disposed between the electrochromic layer and the counter layer.22. The transparent display ...

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Номер записи: 64
25-08-2016 дата публикации

POLYCATIONIC AMPHIPHILES AS ANTIMICROBIAL AGENTS

Номер: US20160242413A1
Автор: MINBIOLE Kevin Patrick, WUEST William
Принадлежит:

The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula 3. The antimicrobial composition of claim 1 , wherein{'sub': 1', '2', '3', '4', '5', '6', '10', '11', '1-4, 'R, R, R, R, R, R, Ror Ris H or a Calkyl; and'}{'sub': 7', '8', '9', '2-5, 'R, Ror Ris a Calkyl unsubstituted or optionally substituted.'}4. The antimicrobial composition of claim 1 , wherein{'sub': 1', '2', '3', '4', '5', '6', '10', '11', '1-12, 'at least one of R, R, R, R, R, R, R, or Ris a Calkyl substituted with a functional group selected from the group consisting of —SH, allyl, and substituted allyl.'}5. The antimicrobial composition of claim 1 , whereinX or Y is chlorine or bromine; andm and n are integers in the range from 10 to 16.7. The antimicrobial composition of claim 6 , wherein each of m and n is 10 claim 6 , 11 or 12 claim 6 , and each of R claim 6 , R claim 6 , R claim 6 , Rand Ris methyl or ethyl claim 6 , and Ris hydrogen claim 6 , methyl or ethyl.9. The antimicrobial composition of claim 7 , wherein the middle nitrogen (N) atom of the compound (10 claim 7 , 3 claim 7 , 0 claim 7 , 3 claim 7 , 10) is further substituted and ionized.11. A method of making the antimicrobial composition of comprising mixing an effective amount of a compound having the formula (I) or (II) and a carrier.12. A method of killing or inhibiting microbial growth claim 1 , comprising applying the antimicrobial composition of comprising a compound having the formula (I) or (II).13. The method of claim 12 , wherein the antimicrobial composition is used to kill or inhibit growth of at least one group of microorganisms selected from the group consisting of bacteria claim 12 , viruses claim 12 , yeast claim 12 , fungi claim 12 , and protozoa claim 12 , or to inhibit formation of a biofilm or eradicate a pre-established biofilm.15. The method of claim 14 , ...

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Номер записи: 65
23-08-2018 дата публикации

ORGANIC COMPOUND, ELECTROCHROMIC ELEMENT, OPTICAL FILTER, LENS UNIT, IMAGE PICKUP APPARATUS, AND WINDOW MEMBER

Номер: US20180237393A1
Автор: Igawa Satoshi, Tamura Tetsuya
Принадлежит:

Provided is an organic compound, which is represented by the general formula (1): 2. An organic compound according to claim 1 , wherein the organic compound has a local maximum absorption wavelength in a range of from 570 nm or more to 800 nm or less in a reduced state.3. An organic compound according to claim 1 , wherein the substituents that the Rand the Rmay have are each independently selected from the group consisting of a halogen atom claim 1 , an alkyl group having 1 or more and 4 or less carbon atoms claim 1 , an alkoxy group having 1 or more and 4 or less carbon atoms claim 1 , an aryl group claim 1 , an aralkyl group claim 1 , and a heteroaryl group.4. An organic compound according to claim 3 , wherein the Rand the Rare each independently selected from the group consisting of the aryl group claim 3 , the aralkyl group claim 3 , and the heteroaryl group claim 3 , and the Rand the Rhave the substituents.5. An organic compound according to claim 1 , wherein the A and the A are identical to each other.6. An organic compound according to claim 1 , wherein the Rand the Rare identical to each other.7. An electrochromic element claim 1 , comprising:a pair of electrodes; andan electrochromic layer arranged between the pair of electrodes,{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'wherein the electrochromic layer contains the organic compound of .'}8. An electrochromic element according to claim 7 , wherein the electrochromic layer further contains another kind of organic compound different from the organic compound represented by the general formula (1).9. An electrochromic element according to claim 8 , wherein the another kind of organic compound is one of a phenazine-based compound claim 8 , a metallocene-based compound claim 8 , a phenylenediamine-based compound claim 8 , and a pyrazoline-based compound.10. An electrochromic element according to claim 7 , wherein the electrochromic layer is a liquid containing an electrolyte.11. An optical filter claim 7 ...

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Номер записи: 66
24-08-2017 дата публикации

Synthesis of 2-carboxamide cycloamino urea derivatives

Номер: US20170240509A1
Автор: ERB Bernhard, Gallou Isabelle Sylvie, Kleinbeck Florian Karl
Принадлежит:

Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore. 1: The compound according to formula (1): The present invention is directed to processes for preparing 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.The processes of the present invention are useful for the preparation of alpha-selective phosphatidylinositol (PI) 3-kinase inhibitor compounds according to formula (X), and intermediates therefore. Phosphatidylinositol 3-kinases (PI3Ks) comprise a family of lipid kinases that catalyze the transfer of phosphate to the D-3′ position of inositol lipids to produce phosphoinositol-3-phosphate (PIP), phosphoinositol-3,4-diphosphate (PIP2) and phosphoinositol-3,4,5-triphosphate (PIP3), which, in turn, act as second messengers in signaling cascades by docking proteins containing pleckstrin-homology, FYVE, Phox and other phospholipid-binding domains into a variety of signaling complexes often at the plasma membrane.PCT Publication No. WO 20101029082 discloses PI3K inhibitors. The compounds disclosed therein include (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) (i.e., the compound of formula (10)). The present invention is directed to improved processes for preparing compounds of the formula (X), specifically the compound of formula (10), as well as useful intermediates such as compounds of the formula (I), specifically the compound of formula (1):Provided herein are processes for the preparation of compounds of formula (X). Also provided herein are intermediate compounds, as well as methods of making those intermediates, that are useful for the preparation of compounds of formula (X). The compounds of formulas (I)-(X) and the compounds of formulas (1) to (8) and (10) refer to the compounds as defined in the description herein.In one aspect, ...

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Номер записи: 67
01-09-2016 дата публикации

Photopolymer formulation for production of holographic media comprising borates with low tg

Номер: US20160252808A1
Автор: Dennis Hönel, Friedrich-Karl Bruder, Günther Walze, Horst Berneth, Marc-Stephan Weiser, Rainer Hagen, Thomas Fäcke, Thomas Rölle
Принадлежит: Covestro Deutschland AG

The invention relates to a photopolymer formulation comprising a component reactive toward isocyanates, a polyisocyanate component, a writing monomer and a photoinitiator containing at least one dye and a coinitiator, characterized in that the coinitiator contains at least one substance of the formula (Ia) The invention further provides a process for preparing the specific coinitiators and the coinitiators obtainable by this process, and additionally a process for producing a holographic medium using the specific coinitiators, and a holographic medium obtainable using the inventive photopolymer formulation. The invention further relates to a laminate structure comprising an inventive holographic medium and likewise specific borates suitable as coinitiators.

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Номер записи: 68
01-09-2016 дата публикации

METHOD FOR PREPARING IONIC LIQUID HAVING CARBOXYLIC ACID ANION USING MICROREACTOR

Номер: US20160254098A1
Автор: HWANG Tae Seop, Jang Jin Young, Jang Kuk Jin, Joo So Kyoung, Kim Wan Joo, Ryu Jung Bok, Yuk Duck Soo
Принадлежит:

The present invention relates to a method for preparing an ionic liquid having a carboxylic acid anion using a microreactor. More specifically, the present invention relates to a method for preparing, with high efficiency, an ionic liquid having a carboxylic acid anion as shown in FIG. by having sodium butanoate, sodium 2-ethylhexanoate, or sodium octanoate undergo a substitution reaction with 1-alkyl-3-methylimidazolium, 1,1-alkylmethylpyrrolidinium, 1,2-dimethyl-3-alkylimidazolium, 1-alkyl-3-methylpyridinium, or tetramethylammonium, each of which being a cation. The ionic liquid prepared according to the present invention has high purity, containing residual halide at less than 10 ppm, and has high electrical conductivity, and therefore is capable of being used as an electrolyte or for a condenser. 1: A method of preparing a high-purity ionic liquid having carboxylic add anion , comprisinghaving sodium butanoate, sodium 2-ethylhexanoate or sodium octanoate undergo a reaction with a halogen salt of 1-alkyl-3-methylimidazolium, 1,1-alkylmethylpyrrolidinium, 1,2-dimethyl-3-alkylimidazolium, 1-alkyl-3-methylpyridinium or tetramethylammonium as starting materials to substitute the anion of the starting materials with butanoate, hexanoate or octanoate, wherein the alkyl group of 1-alkyl-3-methylimidazolium, 1,1-alkylmethylpyrrolidinium, 1,2-dimethyl-3-alkylimidazolium, 1-alkyl-3-methylpyridinium has 1 to 12 carbon atoms and the halogen is fluorine, chlorine, bromine or iodine.2: The method of claim 1 , wherein the solvent for the substitution reaction is water.3: The method of claim 1 , wherein the substitution reaction is carried out within one hour.4: The method of claim 1 , wherein the residual halide of the prepared ionic liquid is less than 20 ppm.5: The method of claim 1 , wherein the substitution reaction is carried out by using a bench reaction or a microreactor. The present invention relates to a method for preparing an ionic liquid having a carboxylic acid ...

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Номер записи: 69
28-09-2017 дата публикации

MODIFIED MITO-METFORMIN COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF

Номер: US20170275313A1
Автор: Hardy Micael J., Kalyanaramn Balaraman, Lopez Marcos, Ouari Olivier, Zielonka Jacek Michal
Принадлежит:

The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer. 1. A modified metformin compound selected from the group consisting of mito-metformin , mito-phenformin , mito-PEG-metformin , mito-cy-metformin or pyrformin.12. A method of inhibiting tumor formation in a subject comprising administering to the subject a therapeutically effective amount of a composition comprising at least one Mito-Metformin compound of .13. A kit comprising at least one mito-metformin compound of claim 1 , a pharmaceutically acceptable carrier or diluent claim 1 , and instructional material. This application claims priority to U.S. Provisional Application 62/037,143 filed Aug. 14, 2014, which is incorporated by reference in its entirety for all purposes.Not Applicable.This invention relates generally to mitochondria-targeting cationic drugs, specifically to mito-metformin compounds, and methods of using the mito-metformin compounds to treat cancer.Metformin, a biguanide from Galega officinalis, is an FDA-approved drug for treating diabetes (9, which inhibits hepatic gluconeogenesis. Metformin exists as a hydrophilic cation at physiological pH and targets mitochondria, albeit rather inefficiently. Metformin has been in use in the clinic for over 50 years and has a very good safety profile (diabetic patients tolerate daily doses of 2-3 grams). However, little is known about its antitumor mechanism of action, and its molecular target(s) still remain unclear. A prevailing view is that metformin's antitumor and antidiabetic effects are due to its ability to sequester into mitochondria and activate the “AMPK/mTOR pathway”, a critical pathway involved in regulating cellular metabolism, energy homeostasis, and cell growth .Previous attempts to improve and enhance the efficacy of metformin have involved increasing its hydrophobicity through attaching alkyl or aromatic groups (butformin, ...

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Номер записи: 70
29-08-2019 дата публикации

METHOD FOR PRODUCING TRIARYLORGANOBORATES

Номер: US20190263838A1
Автор: Berneth Horst, Bruder Friedrich-Karl, Hönel Dennis, Kintrup Jürgen, Rölle Thomas
Принадлежит:

The invention relates to a process for preparing triaryl organoborates proceeding from organoboronic esters in the presence of an n-valent cation 1/n K, comprising the anhydrous workup of the reaction mixture and the use of the triaryl organoborates obtained as co-initiator in photopolymer formulations, holographic media and holograms. 1. Process for preparing triaryl organoborates of the formula 1/n KRB—R(IV) , where one equivalent of organoboronic ester of the formula B—R(OR)(OR) (I) is initially charged together with 1/n equivalents of salt KnX (II) and 3 equivalents of metal M in a solvent or a solvent mixture S1 , 3 equivalents of a haloaromatic R—Y (III) are added , an auxiliary L and optionally a second organic solvent or solvent mixture S2 is added and the compound 1/n KRB—R(IV) is separated off with the organic phase and{'sup': '1', 'sub': 1', '22', '3', '22', '3', '22', '5', '7', '7', '13, 'Ris an optionally hydroxyl- and/or alkoxy- and/or acyloxy- and/or halogen-substituted C- to C-alkyl, C- to C-alkenyl, C- to C-alkynyl, C- to C-cycloalkyl or C- to C-aralkyl radical,'}{'sup': 2', '3', '2', '3, 'sub': 1', '22', '3', '7, 'Rand Rare independently an optionally branched C- to C-alkyl radical or an optionally alkyl-substituted C- to C-cycloalkyl radical or Rand Rtogether form a 2-8-membered carbon bridge which is optionally substituted by alkyl and/or interrupted by oxygen atoms,'}{'sup': '4', 'sub': 6', '10', '1', '4', '1', '4, 'Ris a C- to C-aryl radical optionally substituted by at least one radical selected from halogen, C- to C-alkyl, trifluoromethyl, C- to C-alkoxy, trifluoromethoxy, phenyl and phenoxy,'}K is an organocation of valency n and having any substitution, based on nitrogen, phosphorus, oxygen, sulfur and/or iodine, and{'sup': 2', '3, 'L is an auxiliary that forms a complex of sparing solubility in S1 and/or S2 with M salts MY(OR), MY(OR) and MXY, where L is a Lewis-basic compound, especially selected from the group consisting of open chain or ...

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Номер записи: 71
27-08-2020 дата публикации

ELECTRON DONOR, AND METHOD FOR SYNTHESIZING 4, 4'-BIPYRIDINE USING ELECTRON DONOR

Номер: US20200270212A1
Автор: ASAKO Sobi, FUKUSHIMA Miyuki, MURAKAMI Yoshiaki, TAKAI Kazuhiko
Принадлежит:

Provided are an electron donor that is easy to handle and can be used to carry out a coupling reaction economically and efficiently through simple operations under mild conditions in a short period of time, and a method for synthesizing 4,4′-bipyridine using the electron donor. The electron donor includes a mixture of a dispersion product obtained by dispersing sodium in a dispersion solvent and 1,3-dimethyl-2-imidazolidinone, and this electron donor is used in the method for synthesizing 4,4′-bipyridine. 1. An electron donor comprising a mixture of a dispersion product obtained by dispersing sodium in a dispersion solvent , and 1 ,3-dimethyl-2-imidazolidinone.2. The electron donor according to claim 1 , wherein claim 1 , when the dispersion solvent is a nonpolar solvent that separates from the 1 claim 1 ,3-dimethyl-2-imidazolidinone claim 1 , and a specific gravity of the dispersion solvent is smaller than that of the 1 claim 1 ,3-dimethyl-2-imidazolidinone claim 1 , a lower layer of the mixture that has been divided into two layers is used as the electron donor.3. A method for synthesizing 4 claim 1 ,4′-bipyridine in which 4 claim 1 ,4′-bipyridine is obtained through a reaction between the electron donor according to and pyridine.4. A method for synthesizing 4 claim 2 ,4′-bipyridine in which 4 claim 2 ,4′-bipyridine is obtained through a reaction between the electron donor according to and pyridine. The present invention relates to an electron donor, and a method for synthesizing 4,4′-bipyridine using an electron donor.Coupling reactions are chemical reactions for selectively combining two molecules, particularly cyclic compounds such as aromatic compounds and aromatic heterocyclic compounds, into one molecule. For example, 4,4-bipyridine, which is one isomer of a bipyridine compound obtained by coupling pyridines to each other, can be used to synthesize a porous material through coordinated polymerization with a metal, and there are expectations regarding the ...

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Номер записи: 72
27-08-2020 дата публикации

ENTINOSTAT-CONTAINING COMPOUND, CRYSTAL FORM OF COMPOUND THEREOF, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITION THEREOF

Номер: US20200270213A1
Автор: SHENG Xiaohong, SHENG Xiaoxia
Принадлежит:

The present invention relates to a compound formed by entinostat as shown in formula (I) and acidic counterion. Compared with the known solid form of entinostat, the compound involved has advantages in terms of solubility, stability, etc. The present invention also relates to a crystalline form of the compound and a preparation method therefor, a pharmaceutical composition thereof and the use thereof in the preparation of a drug for preventing and/or treating a disease associated with differentiation or proliferation. 2. The Compound A according to claim 1 , wherein the Compound A is a co-crystal or a salt formed by entinostat and fumaric acid claim 1 , preferably a co-crystal.3. The Compound A according to or claim 1 , wherein the Compound A is crystalline claim 1 , characterized by a X-ray powder diffraction pattern measured using Cu-Kα radiation claim 1 , having the following characteristic peaks at 2θ values: 3.9°±0.2° claim 1 , 13.4°±0.2° claim 1 , 16.4°±0.2° and 18.80° 0.2°.4. The Compound A according to claim 3 , wherein the X-ray powder diffraction pattern of the Crystalline Compound A has the following characteristic peaks at 2θ values of 11.5°±0.2° claim 3 , 15.3°±0.2° claim 3 , 18.3°±0.2° and 19.7°±0.2°.5. The Compound A according to claim 4 , wherein the X-ray powder diffraction pattern of the Crystalline Compound A has the following characteristic peaks at 2θ values of 7.7°±0.2° claim 4 , 10.9°±0.2° claim 4 , 22.8°±0.2° and 26.2°±0.2°.6. The Compound A according to any one of to claim 4 , wherein the Fourier transform infrared spectrum of the Compound A has characteristic peaks at wave numbers of 3369 cm±2 cm claim 4 , 1713 cm±2 cm claim 4 , 1664 cm±2 cm claim 4 , 1605 cm±2 cm claim 4 , 1556 cm±2 cm claim 4 , 1504 cm±2 cm claim 4 , 1282 cm±2 cm claim 4 , 1248 cm±2 cm claim 4 , 1220 cm±2 cm claim 4 , 1135 cm±2 cm claim 4 , 1044 cm±2 cm claim 4 , 759 cm claim 4 , 2 cm claim 4 , 712 cm±2 cmand 640 cm±2 cm.7. A method of preparing the Compound A according ...

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Номер записи: 73
04-10-2018 дата публикации

METHOD FOR SYNTHESIZING BIPYRIDINE COMPOUND AND METHOD FOR MANUFACTURING PYRIDINE COMPOUND

Номер: US20180282278A1
Автор: ASAKO Sobi, FUKUSHIMA Miyuki, Goto Yukihiro, MURAKAMI Yoshiaki, TAKAI Kazuhiko
Принадлежит:

A target bipyridine compound is synthesized with high purity and a high yield in a simple and safe manner in a short period of time. A method for synthesizing a di-tert-butyl-2,2′-bipyridine compound is provided, and the method includes a step of reacting, in a reaction solvent, a tert-butylpyridine compound with a dispersion product obtained by dispersing an alkali metal in a dispersion solvent. A method for synthesizing a bipyridine compound having no substituents is also provided, and the method includes a step of reacting, in a reaction solvent, pyridine with a dispersion product obtained by dispersing an alkali metal in a dispersion solvent. 2. The method for synthesizing a bipyridine compound according to claim 1 , wherein a hydrogen donor is added to a reaction product produced through the reaction of the tert-butylpyridine compound with the dispersion product obtained by dispersing an alkali metal in a dispersion solvent.3. The method for synthesizing a bipyridine compound according to claim 1 , wherein the reaction solvent contains a hydrogen donor.4. The method for synthesizing a bipyridine compound according to claim 1 , wherein the tert-butylpyridine compound is 4-tert-butylpyridine claim 1 , and 4 claim 1 ,4′-di-tert-butyl-2 claim 1 ,2′-bipyridine is synthesized.5. The method for synthesizing a bipyridine compound according to claim 1 , wherein when a ratio of tetrahydrofuran serving as the reaction solvent with respect to 1 mmol of the tert-butylpyridine compound is set to 2 ml or more and 8 ml or less claim 1 , the alkali metal is used in an amount of 1 mol equivalent or more and 2.5 mol equivalents or less with respect to the tert-butylpyridine compound.7. The method for synthesizing a bipyridine compound according to claim 6 , wherein a hydrogen donor is added to a reaction product produced through the reaction of the pyridine with the dispersion product obtained by dispersing an alkali metal in a dispersion solvent.8. The method for synthesizing a ...

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Номер записи: 74
17-09-2020 дата публикации

ELECTROCHEMICAL REDUCTION OF CARBON DIOXIDE

Номер: US20200290030A1
Автор: ISHITANI Osamu
Принадлежит: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Disclosed herein is a method for selectively reducing, using electrical energy, COto carbon monoxide or formic acid, a catalyst for use in the method, and an electrochemical reduction system. The method for producing carbon monoxide or formic acid by electrochemically reducing carbon dioxide of the present invention includes (a) reacting carbon dioxide with a metal complex represented by formula (1), and (b) applying a voltage to a reaction product of the carbon dioxide and the metal complex represented by formula (1):

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Номер записи: 75
03-11-2016 дата публикации

COMPLEXES AND CATALYTIC PROCESSES

Номер: US20160318961A1
Автор: NAVARRO FERNANDEZ OSCAR
Принадлежит:

The present application is directed towards complexes of formula (I), to methods for preparing such complexes, and to use of such complexes in catalysis. The complexes show utility in a range of catalytic cycles, including Pd(ll)/Pd(IV) cycles. (Formula (I)) 2. The complex of wherein the N-heterocyclic carbene ligand L is an imidazol-2-ylidene claim 1 , a tetrahydroimidazol-2-ylidene claim 1 , or a triazol-5-ylidene.4. The complex of any preceding claim claim 1 , wherein M denotes Pd.5. The complex of any preceding claim claim 1 , whereinM denotes Pd;{'sup': '1', 'sub': 1', '4, 'Xdenotes F, Cl, Br, I, or C-C-alkoxide;'}{'sup': 2', 'x, 'sub': 3', '2, 'Xdenotes F, Cl, Br, I, CN, SCN, NCS, Nor RCO;'}{'sup': 'x', 'sub': 1', '4, 'Rdenotes H or C-Calkyl;'}{'sup': 1', '2', 'a, 'sub': 1', '4, 'Rand Rindependently denote C-C-alkyl, cyclohexyl, adamantyl; or phenyl optionally substituted with 1 to 5 R;'}{'sup': 4', '4, 'Z denotes CHRor CR;'}{'sup': 3', '4', 'a, 'sub': 1', '4', '1', '4', '6', '10', '1', '4', '3', '6, 'Rand Rindependently denote H, C-Calkyl, C-C-alkyl-C-C-aryl, C-C-alkyl-C-C-cycloalkyl, which may be optionally substituted by one or more R; or'}{'sup': 3', '4', '4, 'sub': '4', 'Rand Rmay together form —(CH)— when Z denotes CR;'}{'sup': 'a', 'sub': 2', '1', '4', '1', '4, 'each Rindependently denotes halogen, NO, C-C-alkyl, or C-C-alkoxy; and'}Y denotes a non-coordinating cation.6. The complex of any preceding claim claim 1 , wherein Xdenotes Cl.7. The complex of any preceding claim claim 1 , wherein Xdenotes Cl claim 1 , Br or I.8. The complex of any preceding claim claim 1 , wherein Y is chiral.9. The complex of any preceding claim claim 1 , wherein Y is a quaternary ammonium compound claim 1 , a pyridinium cation or an imidazolium cation.12. A method according to claim 11 , whereinL′ denotes NR′R″R′″;wherein{'sub': 1', '4', '3', '6', '6', '10, 'sup': 'a', 'R′, R″ and R′″ each independently denote C-Calkyl, C-Ccycloalkyl or C-Caryl, which may be optionally ...

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Номер записи: 76
12-11-2015 дата публикации

PROCESS FOR PREPARING 2,2-DIFLUOROETHYLAMINE DERIVATIVES BY ALKYLATING 2,2-DIFLUOROETHYLAMINE

Номер: US20150322011A1
Автор: Funke Christian, LUI Norbert, Schnatterer Albert, WARSITZ Rafael
Принадлежит:

A method for preparing a 2,2-difluoroethylamine of the formula (III) in which 2,2-difluoroethylamine of the formula (I) is reacted with a halide of the formula (II) in the presence of a tertiary nitrogen base: 2. Method according to claim 1 , in which the molar ratio of diisopropylethylamine to the halide of the formula (II) used is in the range from 10 to 0.5.3. Method according to claim 1 , in which the molar ratio of halide of the formula (II) to the 2 claim 1 ,2-difluoroethylamine used is in the range from approximately 1:1.5 to approximately 1:20.4. Method according to claim 1 , in which claim 1 , after completion of the method claim 1 , diisopropylethylamine and the 2 claim 1 ,2-difluoroethylamine present in excess are removed and are fed again into the method.5. Method according to claim 1 , with which N-[(6-chloropyridin-3-yl)methyl]-2 claim 1 ,2-difluoroethan- 1-amine of the formula (III) is prepared claim 1 , in which 2-chloro-(5-chloromethyl)pyridine is used as halide of the formula (II). The present invention relates to a method (process) for preparing certain 2,2-difluoroethylamine derivatives starting from 2,2-difluoroethylamine.2,2-Difluoroethylamine derivatives are useful intermediates for preparing active agrochemical ingredients (see WO 2007/115644). Various methods for preparing 2,2-difluoroethylamine derivatives known.WO 2009/036900, for example, describes a method for preparing 2,2-difluoroethylamine derivatives by amide hydrogenation of N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroacetamide (scheme 1).This method is unfavourable due to the use of complex hydrides such as sodium borohydride, since hydrides are expensive to use and raise safety concerns.WO 2009/036901 describes the reduction of N-(6-chloropyridin-3-yl)methylene-2,2-difluoroethanamine by hydrogen (scheme 2).This method is unfavourable due to the use of hydrogen, since the use of hydrogen raises considerable safety concerns here to.WO 2011/157650 describes the preparation of 2,2- ...

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Номер записи: 77
24-09-2020 дата публикации

Reaction medium containing water-surfactant mixture

Номер: US20200299281A1
Автор: Fabrice Gallou, Jianguang Zhou, Michael Parmentier, Pengfei Guo
Принадлежит: NOVARTIS AG

The present invention is directed to reaction mixtures comprising a water-surfactant mixture and a co-solvent. This technology reduced the amount of organic solvents needed for performing chemical reactions. Furthermore, compared to reaction mixtures lacking the co-solvent, solvation of the reactants and products of the chemical reaction is greatly enhanced, leading to a significantly improved yield, purity, reproducibility and robustness.

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Номер записи: 78
19-11-2015 дата публикации

CHEMICAL MODEL OF A NEURODEGENERATIVE DISEASE, METHOD FOR PREPARATION AND USES OF SAME

Номер: US20150328338A1
Автор: LAURENCE CELINE, LEHRI-BOUFALA SONIA, Martens Thierry, MORIN Christophe, Rivard Michael, ZEGHBIB NARIMANE
Принадлежит:

The invention concerns the use of pyridinium furosemide or one of the derivatives, analogues, salts, metabolites, or prodrugs thereof in the preparation of a chemical model of a neurodegenerative disease, preferably Parkinson's disease. The invention also concerns the corresponding chemical model and the uses of same, in particular in screening tests for identifying drug candidates.

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Номер записи: 79
01-11-2018 дата публикации

Odorless thiols for permanent waving, straightening and depilatory applications

Номер: US20180312468A1
Автор: Bryan Patrick Murphy, David Salloum, Guiru Zhang, Stephanie Lee DAVIS
Принадлежит: Procter and Gamble Co

Described herein is a chemical class of odorless thiols which can serve as reducing agents. This chemical class involves thiols which can be used as reducing agents for permanent styling treatments, depilatory compositions and other applications. The odorless thiols are thiols having a heterocyclic quaternary ammonium salt in their molecule.

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Номер записи: 80
16-11-2017 дата публикации

ORGANIC COMPOUND, ELECTROCHROMIC COMPOUND, AND ELECTROCHROMIC ELEMENT, OPTICAL FILTER, LENS UNIT, IMAGING DEVICE, AND WINDOW COMPONENT HAVING SAME

Номер: US20170329195A1
Автор: Igawa Satoshi, Tamura Tetsuya, Yamada Kenji, Yamamoto Jun
Принадлежит:

An organic compound represented by General Formula (1), 2. The organic compound according to claim 1 , wherein the organic compound is colored in a reduced state and has an absorption peak in a wavelength band of 630 nm or more and 750 nm or less in a reduced state.3. The organic compound according to claim 1 , wherein claim 1 , in General Formula (1) claim 1 , Ris an alkyl group having 1 or more and 8 or less carbon atoms.4. The organic compound according to claim 1 , wherein claim 1 , in General Formula (1) claim 1 , Ris an aralkyl group having 1 or more and 8 or less carbon atoms.5. The organic compound according to claim 1 , wherein claim 1 , in General Formula (1) claim 1 , Xand Xare each independently an alkyl group which may have a substituent or an aryl group which may have a substituent.6. The organic compound according to claim 1 , wherein claim 1 , the organic compound is an electrochromic compound a color tone of which claim 1 , is changed by a. redox reaction.7. The organic compound according to claim 1 , wherein the A and the A are same anions.9. An electrochromic element comprising:a pair of electrodes; andan electrochromic layer disposed between the pair of electrodes, wherein{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the electrochromic layer contains the organic compound according to .'}10. The electrochromic element according to claim 9 , wherein the electrochromic layer further contains an organic compound different in type from the; organic compound.11. The electrochromic element according to claim 10 , wherein the organic compound of the different type is any one of a phenazine compound claim 10 , ferrocene claim 10 , a metallocene compound claim 10 , a phenylenediamine compound claim 10 , and a pyrazoline compound.12. The electrochromic element according to claim 9 , wherein claim 9 , the electrochromic layer is liquid having an electrolyte and the organic compound.13. An optical filter comprising:{'claim-ref': {'@idref': 'CLM-00009', ' ...

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Номер записи: 81
08-10-2020 дата публикации

METHOD FOR COUPLING HALOGENATED PYRIDINE COMPOUND WITH HALOGENATED AROMATIC COMPOUND

Номер: US20200317614A1
Автор: FUKUSHIMA Miyuki, MURAKAMI Yoshiaki
Принадлежит:

There is a demand for the development of a technique according to which a reaction for coupling a halogenated pyridine compound with a halogenated aromatic compound can be performed in a simple manner through a small number of steps without using expensive agents such as a palladium catalyst. A method for coupling a halogenated pyridine compound with a halogenated aromatic compound includes a step of coupling a halogenated pyridine compound with a halogenated aromatic compound to obtain a pyridine compound by reacting, in a reaction solvent, the halogenated pyridine compound and the halogenated aromatic compound with a solution containing an alkali metal. 2. The method for coupling a halogenated pyridine compound with a halogenated aromatic compound according to claim 1 , wherein the X1 and the X2 represent a chlorine atom claim 1 , the R1 and the R2 represent a hydrogen atom claim 1 , the Y represents a nitrogen atom claim 1 , and the X′ represents a hydrogen atom or a chlorine atom.3. The method for coupling a halogenated pyridine compound with a halogenated aromatic compound according to claim 2 , wherein the reaction solvent includes chlorobenzene.4. The method for coupling a halogenated pyridine compound with a halogenated aromatic compound according to claim 1 , wherein the X1 represents a chlorine atom claim 1 , the X2 represents a bromine atom claim 1 , the R1 and the R2 represent a hydrogen atom claim 1 , the Y represents a carbon atom claim 1 , and the X′ represents a hydrogen atom.5. The method for coupling a halogenated pyridine compound with a halogenated aromatic compound according to claim 1 , wherein the X1 and the X2 represent a chlorine atom claim 1 , the R1 and the R2 represent a methyl group claim 1 , the Y represents a nitrogen atom claim 1 , and the X′ represents a hydrogen atom or a chlorine atom.6. The method for coupling a halogenated pyridine compound with a halogenated aromatic compound according to claim 1 , wherein the reaction solvent ...

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Номер записи: 82
23-11-2017 дата публикации

KCNQ2-5 CHANNEL ACTIVATOR

Номер: US20170334855A1
Автор: Saito Tetsuji, Wakamatsu Daisuke, Yashiro Kentaro
Принадлежит: ONO PHARMACEUTICAL CO., LTD.

The present invention relates to a compound represented by the general formula (I) (wherein the definition of each group has the same meaning as described in the specification). The compound is useful as preventive and/or therapeutic agent for KCNQ2-5 channel-related diseases. 119-. (canceled)20. A pharmaceutical composition comprising 1-[(5-chloro-2-pyridinyl)methyl]-3-{2 ,6-dichloro-4-[(2S)-1 ,1 ,1-trifluoro-2-hydroxy-2-propanyl]phenyl}urea , or a pharmaceutically acceptable salt thereof , and a pharmaceutically acceptable carrier.21. The pharmaceutical composition according to claim 21 , which is a preventive and/or therapeutic agent for a KCNQ2-5 channel-related disease.22. The pharmaceutical composition according to claim 21 , wherein the KCNQ2-5 channel-related disease is dysuria.23. The pharmaceutical composition according to claim 22 , wherein the dysuria is overactive urinary bladder.24. A method for preventing and/or treating a KCNQ2-5 channel-related disease claim 22 , the method comprising: administering an effective amount of 1-[(5-chloro-2-pyridinyemethyl]-3-{2 claim 22 ,6-dichloro-4-[(2S)-1 claim 22 ,1 claim 22 ,1-trifluoro-2-hydroxy-2-propanyl]phenyl}urea claim 22 , or a pharmaceutically acceptable salt thereof claim 22 , to a mammal.25. The method according to claim 24 , wherein the KCNQ2-5 channel-related disease is dysuria.26. The method according to claim 25 , wherein the dysuria is overactive urinary bladder.27. A pharmaceutical composition comprising 1-[(5-chloro-2-pyridinyl)methyl]-3-{2 claim 25 ,6-dichloro-4-[(2S)-1 claim 25 ,1 claim 25 ,1-trifluoro-2-hydroxy-2-propanyl]phenyl}urea and a pharmaceutically acceptable carrier.28. The pharmaceutical composition according to claim 27 , which is a preventive and/or therapeutic agent for a KCNQ2-5 channel-related disease.29. The pharmaceutical composition according to claim 28 , wherein the KCNQ2-5 channel-related disease is dysuria.30. The pharmaceutical composition according to claim 29 , wherein ...

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Номер записи: 83
23-11-2017 дата публикации

COMPOUNDS FOR REACTIVATION OF ACETYLCHOLINESTERASE AND RELATED COMPOSITIONS METHODS AND SYSTEMS

Номер: US20170335415A1
Автор: BE Nicholas A., BENNION Brian, CARPENTER Tim, ENRIGHT Heather Ann, LIGHTSTONE Felice, MALFATTI Mike, Mcnerney Margaret Windy, Nguyen Tuan H., Valdez Carlos A.
Принадлежит:

Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination. 2. The compound of claim 1 , wherein i=1 claim 1 , j=0 claim 1 , k=0 claim 1 , R12 and R16 are bonded to form an aromatic or aliphatic cycle.3. The compound of claim 1 , wherein i=1 claim 1 , j=0 claim 1 , k=0 claim 1 , R11 and R12 are bonded to form an aromatic or aliphatic cycle.4. The compound of claim 1 , wherein R16 and R17 are bonded to form an aromatic or aliphatic cycle.6. The compound of claim 3 , wherein R11 and R16 are bonded to form part of an aromatic or aliphatic cycle.7. The compound of claim 4 , wherein R12 and R16 are bonded to form an aromatic or aliphatic cycle.17. The compound of claim 1 , wherein the compound has a clogP in the range of 2.0 to 4.5.18. The compound of claim 1 , wherein the compound has a clogP in the range of 0 to 2.19. The compound of claim 1 , wherein the compound has a pKa between 7 to 9.20. The compound of claim 1 , wherein at least 20% of the compound is in the un-protonated form under physiological conditions.21. A method to reactivate a nerve agent inhibited acetylcholinesterase in an individual claim 1 , the method comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'administering to the individual an effective amount of at least one compound of for a time and under a condition to allow contact between the at least one compound and a nerve agent inhibited acetylcholinesterase in the individual thus resulting in a reactivated acetylcholinesterase.'}22. A method of treating and/or preventing a condition of an individual claim 1 , the condition associated with exposure of the individual to a nerve agent claim 1 , the method ...

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Номер записи: 84
03-12-2015 дата публикации

LUMINESCENT MATERIAL FOR ORGANIC OPTOELECTRIC DEVICE AND ORGANIC OPTOELECTRIC DEVICE AND DISPLAY DEVICE

Номер: US20150349269A1
Автор: HAN Su-Jin, Hong Jin-Seok, JANG Yu-Na, JEONG Soo-Young, KANG Dong-Min, KANG Eui-Su, LEE Han-Ill, Lee Sang-Shin, RYU Dong-Kyu, Yu Eun-Sun
Принадлежит:

Disclosed are an organic compound represented by the Chemical Formula 1, an organic optoelectric device including the organic compound, and a display device including the organic optoelectric device. 3. The organic compound of claim 1 , wherein L is a substituted or unsubstituted phenylene group having a kink structure claim 1 , a substituted or unsubstituted biphenylene group having a kink structure claim 1 , or a substituted or unsubstituted terphenylene group having a kink structure.5. The organic compound of claim 1 , wherein the organic compound includes at least two kink structures.9. The organic compound of claim 1 , wherein the organic compound has a LUMO energy of −2.0 to −2.5 eV.10. An organic optoelectric device comprisingan anode and a cathode facing each other, andat least one organic layer positioned between the anode and the cathode,{'claim-ref': {'@idref': 'CLM-00001', 'claims 1'}, 'wherein the at least one organic layer includes the organic compound according to .'}11. The organic optoelectric device of claim 10 , wherein:the at least one organic layer includes an emission layer, andthe emission layer includes the organic compound.12. The organic optoelectric device of claim 11 , wherein the organic compound is a host in the emission layer.13. The organic optoelectric device of claim 10 , further comprising at least one auxiliary layer selected from a hole injection layer claim 10 , a hole transport layer claim 10 , an electron blocking layer claim 10 , an electron transport layer claim 10 , an electron injection layer claim 10 , and a hole blocking layer claim 10 ,wherein the at least one auxiliary layer includes the organic compound.14. A display device comprising the organic optoelectric device according to . An organic compound, an organic optoelectric device, and a display device are disclosed.An organic optoelectric device is a device that converts electrical energy into photoenergy, and vice versa.An organic optoelectric device may be ...

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Номер записи: 85
22-11-2018 дата публикации

HOMOGENEOUS PROCESS FOR HYDRODEHALOGENATING HALOGENATED HETEROARYL COMPOUNDS

Номер: US20180334433A1
Автор: MORTIMER Danny Lee
Принадлежит:

The present invention provides a homogeneous process for hydrodehalogenating a halo-substituted C-Cheteroaryl starting material to form a non-halogenated C-Cheteroaryl product and/or a halo-substituted C-Cheteroaryl product, wherein the halo-substituted C-Cheteroaryl product has at least one less halogen substituents than the halo-substituted C-Cheteroaryl starting material, the process comprising the step of hydrogenating the halo-substituted C-Cheteroaryl starting material in the presence of a rhodium or ruthenium complex, molecular hydrogen, a base and a solvent, wherein the process is carried out in a monophasic solvent system and the molar ratio of base to each halogen substituent to be removed is at least 1:1. 1. A homogeneous process for hydrodehalogenating a halo-substituted C-Cheteroaryl starting material to form a non-halogenated C-Cheteroaryl product and/or a halo-substituted C-Cheteroaryl product , wherein the halo-substituted C-Cheteroaryl product has at least one less halogen substituent than the halo-substituted C-Cheteroaryl starting material , the process comprising the step of:{'sub': 3', '20, 'hydrogenating the halo-substituted C-Cheteroaryl starting material in the presence of a rhodium or ruthenium complex, molecular hydrogen, a base and a solvent, wherein the process is carried out in a monophasic solvent system and the molar ratio of base to each halogen substituent to be removed is at least 1:1.'}2. The process of claim 1 , wherein the halo-substituted C-Cheteroaryl starting material has a number of halogen substituents which is ≥2 and up to the limitations imposed by the rules of valence.3. The process of claim 1 , wherein the halo-substituted C-Cheteroaryl starting material is a halo-substituted C-Cheteroaryl starting material.4. The process of claim 1 , wherein the halo-substituted C-Cheteroaryl starting material is a halo-substituted C-Cnitrogen-containing heteroaryl starting material.5. The process of claim 1 , wherein the halo- ...

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Номер записи: 86
14-12-2017 дата публикации

SYNTHESIS OF 2-CARBOXAMIDE CYCLOAMINO UREA DERIVATIVES

Номер: US20170355677A1
Автор: ERB Bernhard, Gallou Isabelle Sylvie, KLEINBECK-RINIKER Florian Karl
Принадлежит: NOVARTIS AG

Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore. 2: The process of wherein the solvent of Step B comprises an alcohol solvent.3: The process of claim 1 , wherein the solvent of step C comprises an ethereal solvent claim 1 , wherein the ethereal solvent is tetrahydrofuran.4: The process of claim 1 , wherein the solvent of step C comprises an aromatic solvent claim 1 , wherein the aromatic solvent is toluene.5: The process of wherein the base of Step C is an amine.6: The process of claim 1 , wherein the solvent of Step D is selected from tetrahydrofuran claim 1 , toluene claim 1 , water or a combination thereof.7: The process of claim 1 , wherein the solvent of Step B comprises an alcohol solvent; the solvent of step C comprises an ethereal solvent claim 1 , wherein the ethereal solvent is tetrahydrofuran; the base of Step C is an amine; and the solvent of Step D comprises tetrahydrofuran and water.8: The process of claim 1 , wherein the solvent of Step B comprises an alcohol solvent; the solvent of step C comprises an aromatic solvent claim 1 , wherein the aromatic solvent is toluene; and the solvent of Step D comprises toluene. The present invention is directed to processes for preparing 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.The processes of the present invention are useful for the preparation of alpha-selective phosphatidylinositol (PI) 3-kinase inhibitor compounds according to formula (X), and intermediates therefore. Phosphatidylinositol 3-kinases (PI3Ks) comprise a family of lipid kinases that catalyze the transfer of phosphate to the D-3′ position of inositol lipids to produce phosphoinositol-3-phosphate (PIP), phosphoinositol-3,4-diphosphate (PIP2) and phosphoinositol-3,4,5-triphosphate (PIP3), which, in turn, act as second messengers in signaling cascades by docking proteins containing pleckstrin-homology ...

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Номер записи: 87
24-12-2015 дата публикации

PROCESSES FOR PREPARING L-ALKYL-3-ALKYL-PYRIDINIUM BROMIDE AND USES THEREOF AS ADDITIVES IN ELECTROCHEMICAL CELLS

Номер: US20150372351A1
Автор: BEN DAVID Iris, BERGSTEIN-FREIBERG Mira, Lancry Eli, MAGNES Ben-Zion, ZER-ZION Nirit
Принадлежит:

The invention relates to the use of at least one 1-alkyl-3-alkyl-pyridinium halide, in particular 1-alkyl-3-methyl-pyridinium bromide, as an additive in bromine-generating electrochemical cells, such as zinc/bromine cells. Processes for preparing 1-alkyl-3-methyl-pyridinium bromide and concentrated aqueous solutions comprising same for use as additives in the aforementioned cells, are also disclosed. 1) An electrolyte solution suitable for use in bromine-generating electrochemical cells , comprising aqueous bromide and a liquid complex composed of at least one 1-alkyl-3-alkyl-pyridinium halide combined with one or more bromine molecules.2) An electrolyte solution according to claim 1 , wherein the aqueous bromide is an aqueous solution of zinc bromide.3) An electrolyte solution according to claim 1 , wherein the 1-alkyl-3-alkyl-pyridinium halide is 1-alkyl-3-methyl-pyridinium bromide.4) An electrolyte solution according to claim 3 , wherein the alkyl at position 1 is C3-C10 alkyl group claim 3 , which may be either straight-chain or branched.5) An electrolyte solution according to claim 4 , wherein the C3-C10 alkyl group is selected from the group consisting of n-propyl claim 4 , n-butyl claim 4 , n-pentyl and n-hexyl.6) An electrolyte solution according to claim 5 , comprising 1-n-butyl-3-methyl-pyridinium bromide.7) An electrolyte solution according to claim 6 , further comprising at least one compound selected from the group consisting of 1-n-propyl-3-methyl-pyridinium bromide claim 6 , 1-n-pentyl-3-methyl-pyridinium bromide and 1-n-hexyl-3-methyl-pyridinium bromide.9) An electrolyte solution according to claim 6 , wherein the compound of Formula (I) is selected from the group consisting of N-alkyl pyridinium bromide and 1-alkyl-2-methyl pyridinium bromide; the compound of Formula (II) is selected from the group consisting of N-methyl-N-alkyl pyrrolidinium bromide claim 6 , wherein said alkyl group attached to the pyrrolidinium ring comprises not less than four ...

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Номер записи: 88
14-11-2019 дата публикации

FLUORESCENT HALOGEN BONDING ARYLETHYNYL SCAFFOLDS FOR ANION RECOGNITION

Номер: US20190345113A1
Автор: Berryman Orion B., Decato Daniel A., Haley Michael M., Johnson Darren W., Lohrman Jessica, Riel Asia M.
Принадлежит:

A compound, or a protonate or salt thereof, of formula I: 4. The compound of claim 3 , wherein Ris methyl.5. The compound of claim 2 , wherein Z is —NH claim 2 , —Br claim 2 , or —I.7. The compound of claim 1 , wherein n is 1.8. The compound of claim 1 , wherein a is 1.10. The compound of claim 1 , wherein Ris alkyl claim 1 , substituted alkyl claim 1 , substituted sulfonyl claim 1 , or substituted carboxyl.11. The compound of claim 1 , wherein Ris unbranched alkyl claim 1 , —CF claim 1 , sulfonylCalkyl claim 1 , or —COOR wherein R is alkyl.12. The compound of claim 1 , wherein a is 1 and both Rare the same.13. The compound of claim 1 , wherein at least one R is —I.14. The compound of claim 1 , wherein both R groups are —I.15. The compound of claim 1 , wherein the compound is protonated.17. The compound of claim 16 , wherein both R groups are —I.20. The compound of claim 19 , wherein Z is —NHand Z′ is —F.21. The compound of claim 19 , wherein both R groups are —I.22. The compound of claim 19 , wherein both R groups are hydrogen.23. The compound of claim 19 , wherein both Rgroups are alkyl.24. A receptor-ligand structure comprising the compound of as a receptor and a ligand.25. A receptor-ligand structure comprising the compound of as a receptor and a ligand that includes at least one anion selected from Cl claim 1 , Br claim 1 , I claim 1 , HPO claim 1 , HSO claim 1 , ClO claim 1 , NO claim 1 , PF claim 1 , TsO claim 1 , OTf claim 1 , BAr claim 1 , BF claim 1 , HS claim 1 , SbF claim 1 , ReO claim 1 , TcO or SCN.26. A method for detecting for the presence of an anion in a system claim 1 , comprising contacting a sample from the system with a compound claim 1 , or a protonate or salt thereof claim 1 , of .27. A receptor-ligand structure comprising the compound of as a receptor and a ligand.28. A receptor-ligand structure comprising the compound of as a receptor and a ligand that includes at least one anion selected from Cl claim 19 , Br claim 19 , I claim 19 , HPO ...

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Номер записи: 89
21-12-2017 дата публикации

CHEMICAL MODEL OF A NEURODEGENERATIVE DISEASE, METHOD FOR PREPARATION AND USES OF SAME

Номер: US20170360964A1
Автор: LAURENCE CELINE, LEHRI-BOUFALA SONIA, Martens Thierry, MORIN Christophe, Rivard Michael, ZEGHBIB NARIMANE
Принадлежит:

The invention concerns the use of pyridinium furosemide or one of the derivatives, analogues, salts, metabolites, or prodrugs thereof in the preparation of a chemical model of a neurodegenerative disease, preferably Parkinson's disease. The invention also concerns the corresponding chemical model and the uses of same, in particular in screening tests for identifying drug candidates. 2. The method of claim 1 , wherein the synucleinopathy is Parkinson's disease.3. The method of claim 1 , wherein the non-human animal is selected from the group consisting of a non-human mammal claim 1 , an invertebrate claim 1 , and a fish.4. The method of claim 1 , wherein the compound is furosemide pyridinium.5. A non-human model of a synucleinopathy obtained according to the method of .7. The method of claim 6 , wherein the compound is furosemide pyridinium.8. The method of claim 7 , wherein said marker characteristic of the synucleinopathy is selected from the group consisting of a motor disorder claim 7 , a degeneration of dopaminergic neurons claim 7 , a sleep or arousal disorder claim 7 , the intracellular accumulation of alpha-synuclein in a dopaminergic neuron claim 7 , and combinations thereof in said non-human animal.9. The method of claim 6 , wherein the cell system is a nematode claim 6 , a zebrafish claim 6 , or a larvae thereof.11. A method for inducing in a non-human mammal one or more symptoms associated with Parkinson's disease claim 1 , comprising a step of administering the compound according to to the non-human mammal. This application is a divisional of U.S. application Ser. No. 14/443,499, filed May 18, 2015, now U.S. Pat. No. 9,744,250, which is the U.S. national stage application of International Patent Application No. PCT/FR2013/052784, filed Nov. 19, 2013.The invention relates to the development and use of chemical models for the study of a neurodegenerative disease, particularly Parkinson's disease.Parkinson's disease is the second most common ...

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Номер записи: 90
21-12-2017 дата публикации

CHELATION DIRECTED C-H ACTIVATION REACTIONS CATALYZED BY SOLID-SUPPORTED PALLADIUM(II) CATALYSTS

Номер: US20170362181A1
Автор: ELLIS Keith C., GUPTON Frank B.
Принадлежит:

Chelation directed C—H activation reactions that are catalyzed by Pd(11) on Multi-Walled Carbon Nanotubes (MWCNT), Single-Walled Carbon Nanotubes (SWCNT), or graphene are provided. The reactions are used to directly and regioselectively or regiospecifically functionalize specific C—H bonds, e.g. to build complexity into small molecules. Features and advantages of the present invention will be set forth in the description of invention that follows, and in part will be apparent from the description or may be learned by practice of the invention. The invention will be realized and attained by the compositions and methods particularly pointed out in the written description and claims hereof. 1. A method for selectively producing functionalized aryl or heteroaryl compounds , comprising the steps of:combining an aryl or heteroaryl compound containing at least one C—H group with a solid-supported Pd(II) catalyst selected from the group consisting of Pd(II)/MWCNT, Pd(II)/SWCNT and Pd(II)/graphene, wherein said combining is performed under conditions wherein said solid-supported Pd(II) catalyst selectively catalyzes a reaction which attaches a functional group to said aryl or heteroaryl compound at said at least one C—H group as a reaction product; andseparating said solid-supported Pd(II) catalyst from said reaction product.2. The method of further comprising the steps ofrecovering said solid-supported Pd(II) catalyst after said separating step; andrepeating said steps of combining and separating using at least some of said solid-supported Pd(II) catalyst recovered in said recovering step.3. A solid-supported Pd(II) catalyst selected from the group consisting of Pd(II)/MWNCT claim 1 , Pd(II)/SWCNT and Pd(II)/graphene claim 1 , wherein said solid-supported Pd(II) catalyst is present as a powder or a dispersion in a fluid and wherein said solid-supported Pd(II) catalyst has a purity with respect to Pd(0) or Pd(IV) species of at least 90%.4. A method of catalyzing a reaction ...

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Номер записи: 91
21-11-2019 дата публикации

Organic Electroluminescent Devices and Metal Complex Compounds

Номер: US20190355918A1
Автор: Ichijima Seiji, Igarashi Tatsuya, Ise Toshihiro, Nii Kazumi, WATANABE Kousuke
Принадлежит:

An organic electroluminescent device, which has a pair of electrodes and at least one organic layer including a luminescent layer between the pair of electrodes, wherein at least one layer between the pair of electrodes comprises at least one metal complex having a tridentate- or higher polydentate-chain structure ligand. 112.-. (canceled)14. The compound of claim 13 , wherein Yand Yeach independently represent a single bond claim 13 , a carbonyl-linking group claim 13 , an alkylene linking group claim 13 , or an alkenylene group.15. The compound of claim 13 , wherein Yrepresents a single bond claim 13 , a carbonyl-linking group claim 13 , an alkylene linking group claim 13 , or an alkenylene group.16. The compound of claim 13 , wherein at least one ring formed with Qor Qis a pyridine ring claim 13 , a pyrazine ring claim 13 , a pyrimidine ring claim 13 , a triazine ring claim 13 , an oxazole ring claim 13 , a pyrrole ring claim 13 , or a condensed ring thereof.17. The compound of claim 13 , wherein R claim 13 , R claim 13 , R claim 13 , and Reach represent an alkyl group claim 13 , an aryl group claim 13 , or a group that forms a condensed ring by forming a bond between Rand Ror by forming a bond between Rand R.18. The compound of claim 17 , wherein the condensed ring formed by Rand Ror Rand Ris a benzene ring or a pyridine ring.20. The organic electroluminescent device of claim 19 , wherein in the complex represented by formula (9) claim 19 , Yand Yeach independently represent a single bond claim 19 , a carbonyl-linking group claim 19 , an alkylene linking group claim 19 , or an alkenylene group.21. The organic electroluminescent device of claim 19 , wherein in the complex represented by formula (9) claim 19 , Yrepresents a single bond claim 19 , a carbonyl-linking group claim 19 , an alkylene linking group claim 19 , or an alkenylene group.22. The organic electroluminescent device of claim 19 , wherein in the complex represented by formula (9) claim 19 , at least ...

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Номер записи: 92
26-11-2020 дата публикации

ESTER NITRATES DERIVATIVES OF AROMATIC ALDEHYDES WITH MULTIPLE PHARMALOGIC PROPERTIES TO TREAT SICKLE CELL DISEASE

Номер: US20200369638A1
Автор: Danso-Danqua Richmond, Deshpande Tanvi, Safo Martin, VENITZ Jurgen, Zhang Yan
Принадлежит:

The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention. 157-. (canceled)63. A method for treating a subject having sickle cell disease (SCD) claim 58 , comprising administering to the subject a therapeutically effective amount of a compound according to . The invention relates to aromatic aldehydes and their use in the treatment of Sickle Cell Disease.Sickle cell disease (SCD) is the consequence of substitution of Glu by Va1 in the 6position of the β-globin chain of hemoglobin (Hb) resulting in the formation of sickle Hb (HbS). Intracellular polymerization of deoxygenated sickle Hb into long, rigid and insoluble fibres causes the pathophysiology associated with SCD; facilitating a cascade of adverse events that include decreased nitric oxide (NO) bioavailability, endothelial cell activation, compensatory vasoconstriction, increase in neutrophil count, adhesion of red blood cells (RBCs) to tissue endothelium, vaso-occlusion and impaired microvascular blood flow. The clinical condition is characterized by chronic hemolytic anemia, frequent and severe painful crises, and multi-system pathology that impact nearly every organ.Individuals with SCD have shown significant levels of pro-inflammatory cytokines, such as TNF-α which can trigger the painful vaso-occlusive crises and lead to the emergence of infectious and inflammatory episodes. TNF-α also stimulates production of free radicals and other inflammatory mediators, such as IL-1 and PGE2, and induce changes in coagulant and anticoagulant properties. Individuals with SCD have also shown decreased NO physiological levels in vascular endothelium that have also been linked to hemolysis, inflammation, ...

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Номер записи: 93
03-12-2020 дата публикации

Method for the synthesis and isolation of facial-tris-homoleptic phenylpyridinato iridium (iii) photocatalysts

Номер: US20200376474A1
Автор: Jimmie Dean Weaver, Kip Allen Teegardin
Принадлежит: Oklahoma State University

Methods of synthesizing and isolating facial-tris-homoleptic phenylpyridinato iridium (III) photocatalysts are disclosed. Also disclosed are methods of recovering excess 2-phenylpyridine ligands from said syntheses.

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Номер записи: 94
05-12-2019 дата публикации

COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME

Номер: US20190372016A1
Автор: Chen Chi-Chung, SHIEH Shwu-Ju
Принадлежит:

Provided are a novel compound and an organic electronic device using the same. The novel compound is represented by the following Formula (I): 2. The compound as claimed in claim 1 , wherein a in Formula (I) is the integer 1.4. The compound as claimed in claim 1 , wherein the heteroaryl group having 3 to 60 ring carbon atoms represented by G in Formula (I) is selected from the group consisting of: a furyl group claim 1 , a pyrrolyl group claim 1 , a thiophenyl group claim 1 , an imidazolyl group claim 1 , a pyrazolyl group claim 1 , a triazolyl group claim 1 , a tetrazolyl group claim 1 , an oxazolyl group claim 1 , an isoxazolyl group claim 1 , a thiazolyl group claim 1 , an isothiazolyl group claim 1 , an oxadiazolyl group claim 1 , a thiadiazolyl group; a pyridyl group claim 1 , a pyridazinyl group claim 1 , a pyrimidinyl group claim 1 , a pyrazinyl group claim 1 , a triazinyl group; an indolyl group claim 1 , an isoindolyl group claim 1 , a benzofuranyl group claim 1 , an isobenzofuranyl group claim 1 , a benzothiophenyl group claim 1 , an isobenzothiophenyl group claim 1 , an indolizinyl group claim 1 , a quinolizinyl group claim 1 , a quinolyl group claim 1 , an isoquinolyl group claim 1 , a cinnolyl group claim 1 , a phthalazinyl group claim 1 , a quinazolinyl group claim 1 , a quinoxalinyl group claim 1 , a benzimidazolyl group claim 1 , a benzoxazolyl group claim 1 , a benzothiazolyl group claim 1 , an indazolyl group claim 1 , a benzisoxazolyl group claim 1 , a benzisothiazolyl group; a dibenzofuranyl group claim 1 , a dibenzothiophenyl group claim 1 , a carbazolyl group claim 1 , a biscarbazolyl group claim 1 , a coumarinyl group claim 1 , a chromenyl group claim 1 , a phenanthridinyl group claim 1 , an acridinyl group claim 1 , a phenanthrolinyl group claim 1 , a phenazinyl group claim 1 , a phenothiazinyl group claim 1 , a phenoxazinyl group claim 1 , an azatriphenylenyl group claim 1 , a diazatriphenylenyl group claim 1 , a xanthenyl group claim 1 , an ...

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Номер записи: 95
31-12-2020 дата публикации

COMPOUND AND DIMER COMPLEX EMBODIMENTS FOR SUPRAMOLECULAR SENSING

Номер: US20200407318A1
Автор: Beatty Meagan, Hof Fraser, Selinger Allison
Принадлежит:

Disclosed herein are embodiments of a compound that can be used as a supramolecular sensor for determining the presence of analytes (e.g., illicit drugs), and for identifying and/or quantifying the analytes. Also disclosed herein is a parallel synthesis method for making compound embodiments, as well as method embodiments for using the compound embodiments. Array embodiments comprising one or more compound embodiments disclosed herein also are described. 3. The compound of claim 1 , wherein the Ring B and/or the Ring groups independently comprise a detectable moiety.4. The compound of claim 1 , wherein the Ring B and/or the Ring groups independently comprise an N-functionalized nitrogen-containing ring system claim 1 , a 2-ethyl-1H-benzo[de]isoquinoline-1 claim 1 ,3(2H)-dione functional group claim 1 , or a nitrobenzo[c][1 claim 1 ,2 claim 1 ,5]oxadiazole functional group.9. A sensor array claim 1 , comprising:a substrate; and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'one or more compounds according to associated with the substrate.'}10. A method claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'exposing a sample to one or more compounds according to ; and'}determining whether an analyte is present in the sample.11. The method of claim 10 , wherein the sample is an aqueous sample claim 10 , a saliva sample claim 10 , a urine sample claim 10 , a nasal wash sample claim 10 , a synovial fluid sample claim 10 , a cerebrospinal fluid sample claim 10 , a gastric fluid sample claim 10 , a serum sample claim 10 , a plasma sample claim 10 , a cell growth medium sample claim 10 , a cell lysate sample claim 10 , or any combination thereof.12. The method of claim 10 , wherein the compound interacts with any analytes present in the sample to produce a detectable signal.13. The method of claim 12 , wherein the detectable signal is a colorimetric signal or a fluorescent signal and the analyte is an illicit drug.14. The method of claim 12 , wherein the ...

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Номер записи: 96
31-12-2020 дата публикации

ELECTROCHROMIC FILMS AND METHODS OF FORMING AND USING

Номер: US20200409225A1
Автор: Looman Steven D.
Принадлежит:

An electro-optic element includes a first electroactive film including a first electroactive component sequestered adjacent to a first electrically conductive layer and a second electroactive film including a second electroactive component sequestered adjacent to a second electrically conductive layer. At least one of the first electroactive film and the second electroactive film is capable of reversibly attenuating transmittance of light having a wavelength within a predetermined wavelength range. The first electroactive component can include a first oxidation state and at least a second oxidation state. An amount of the first electroactive component relative to the second electroactive component can be configured to limit formation of the second oxidation state of the first electroactive component. 1. An electro-optic element , comprising:a cathodic film including a cathodic component sequestered adjacent to a first electrically conductive layer by a first polymer matrix; andan anodic film including an anodic component sequestered adjacent to a second electrically conductive layer by a second polymer matrix;wherein at least one of the cathodic film and the anodic film is capable of reversibly attenuating transmittance of light having a wavelength within a predetermined wavelength range, andwherein the cathodic film and anodic film are configured such that the cathodic component is present in excess relative to the anodic component.2. The electro-optic element of claim 1 , wherein:the cathodic component is confined within the first polymer matrix or covalently bonded to the first polymer matrix; andthe anodic component is confined within the second polymer matrix or covalently bonded to the second polymer matrix.3. The electro-optic element of claim 1 , wherein a charge capacity of the cathodic film is greater than a charge capacity of the anodic film.4. The electro-optic element of claim 1 , wherein a ratio of a molar amount of the cathodic component in the ...

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Номер записи: 97
18-10-2007 дата публикации

Substituted enaminocarbonyl compounds

Номер: WO2007115644A1
Автор: Christian Arnold, Erich Sanwald, Leonardo Pitta, Michael Edmund Beck, Olga Malsam, Otto Schallner, Peter Jeschke, Ralf Nauen, Robert Velten, Rolf Pontzen, Thomas Müller, Thomas Schenke, Udo Reckmann, Ulrich Görgens
Принадлежит: Bayer CropScience AG

The present application relates to novel substituted enaminocarbonyl compounds of formula (I), to a method for producing said compounds and to their use for controlling animal pests, particularly arthropods and more particularly insects.

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Номер записи: 98
19-07-2001 дата публикации

4-aminopicolinates and their use as herbicides

Номер: WO2001051468A1
Автор: Anita Lenora Alexander, Ann Marie Buysse, Christian Thomas Lowe, James Melvin Ruiz, John Sanders Richburg, Karl Leopold Krumel, Leslie Anne Bjelk, Renee Joan Keese, Stephen Craig Fields, Terry William Balko, William Chi-Leung Lo
Принадлежит: DOW AGROSCIENCES LLC

4-Aminopicolinic acids, having halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluoromethyl substituents in the 3-, 5- and 6-positions, and their amine and acid derivatives of formula (I) wherein X represents H, halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, nitro, or trifluoromethyl; Y represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, heteroaryloxy or trifluoromethyl; Z represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy or nitro; and W represents -NO2, -N3, -NR1R2, -N=CR3R4 or -NHN=CR3R4 are potent herbicides demonstrating a broad spectrum of weed control.

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Номер записи: 99
25-04-2002 дата публикации

Light-emitting device and iridium complex

Номер: US20020048689A1
Автор: Keizo Kimura, Tatsuya Igarashi
Принадлежит: Fuji Photo Film Co Ltd

A light-emitting device comprising a pair of electrodes, and organic compound layers comprising a light-emitting layer provided in between the electrodes, wherein at least one of the organic compound layers comprises a compound having a transition metal atom-phosphorus atom bond.

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Номер записи: 100