Ионные жидкости

... 1. Ионные растворы общей формулы К+А- (I) в которой K+ обозначает катион, который выбирают из группы, состоящей из где R1-R5 являются идентичными или отличаются друг от друга, необязательно связаны напрямую друг с другом посредством одинарной либо двойной связи и, каждый, в отдельности или совместно, имеют следующие значения Н, галоген, алкильный радикал (от C1 до С8), который может быть частично или полностью замещенным другими группами, предпочтительно F, Cl, N(CnF(2n+1-х)Нх)2, O(CnF(2n+1-x)Hx), SO2(CnF(2n+1-x)Hx) или CnF(2n+1-x)Hx, где 1 Подробнее

ГЕТЕРОЦИКЛИЧЕСКИЕ ПРОИЗВОДНЫЕ КАРБОНОВОЙ КИСЛОТЫ И ИХ СОЛИ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ С АНТИФИБРОТИЧЕСКОЙ ИЛИ ТОРМОЗЯЩЕЙ ПРОЛИЛГИДРОКСИЛАЗУ ИЛИ БИОСИНТЕЗ КОЛЛАГЕНА АКТИВНОСТЬЮ

Гетероциклические производные карбоновой кислоты и их соли могут представлять собой активное вещество фармацевтической композиции с антифибротической или тормозящей пролилгидроксилазу или биосинтез коллагена активностью.

SUBSTITUTED BENZAMIDES

Method of preparation of new basic esters.

NEUE SUBSTITUIERTE BENZAMIDE, VERFAHREN ZU IHRER HERSTELLUNG UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN, DIE DIESE BENZAMIDE ENTHALTEN

Novel substituted benzamides of the formula XXI wherein R1, R2, R3, R4, R5 and A are as defined herein are useful in the treatment of emesis, and particularly chemotherapy-induced emesis in cancer patients. Some of the compounds are also useful in disorders relating to impaired gastric motility.

TEST PROCEDURE WITH IMPROVED CHEMILUMINESZIERENDEN ESTERS, THIOESTERN AND AMIDES

VERFAHREN ZUR HERSTELLUNG VON ACYLCYANIDEN

PROCEDURE FOR THE PRODUCTION OF ECYL CYANIDES

IONI LIQUIDS

PROCEDURE FOR THE PRODUCTION OF NEW N (6) - ARALKYL ADENOSINE DERIVATIVES

DIARYLMETHAN SULFONAMID DERIVATIVES, PROCEDURES FOR YOUR PRODUCTION AND THESE CONTAINING PHARMACEUTICAL COMPOSITIONS.

ANTIBIOTIC EFFECTS ISOXAZOLDERIVATE, ITS PRODUCTION AND USE.

PROCEDURE FOR THE PRODUCTION OF NEW FLUORALKOXYPHENYL SUBSTITUTING NITROGEN HETERO CYCLES AND YOUR SALTS

ETHYNYL ALANINE AMINODIOLVERBINDUNGEN WITH PIPERAZINYLENDGRUPPE OR PIPERAZINYL ALKYLAMINO ENDGRUPPE FOR THE TREATMENT OF HYPERTENSION

1,1-DISUBSTITUTED CYCLOPROPANE DERIVATIVES

Process and intermediates for growth hormone secretagogues

FLUOROALKYXYPHENYL-SUBSTITUTED NITROGEN HETEROCYCLES

N(6)-ARALKYL ADENOSINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

IONIC LIQUIDS

The invention relates to ionic liquids for use in electrochemical cells and for organic syntheses.

Verfahren zur Herstellung von neuen substituierten Phenylacetamiden

Procédé pour préparer des dioxydes de benzothiazine

PROCEDURE FOR THE PRODUCTION OF NEW OF SUBSTITUTING BETA AMINOPROPIONSAEURE ONES AND THEIR ESTER.

PROCEDURE FOR THE PRODUCTION OF NEW BENZIMIDAZOLE.

5-CARBOXAMIDES PREPARATION DE PROCEDE DE DERIVES DE TETRAZOLES-.

PROCEDURE FOR THE PRODUCTION OF ECYL CYANIDES.

PROCEDURE FOR THE PRODUCTION OF ECYL CYANIDES.

PHARMAKOLOGISCH ACTIVE ONE, SUBSTITUTED BENZAMIDVERBINDUNGEN.

DINITROBENZOIC 2.4 [...] AND 6 OF ANILINES, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR DYEING OF KERATIN FIBERS, ESPECIALLY HUMAN HAIR.

INHIBITORS OF MAGL BASED ON PYRAZOLE

СПОСОБ ПОЛУЧЕНИЯ 2-(3-ЦИКЛОГЕКСИЛ-2,4-ДИОКСО-2,3,4,5,6,7-1H-ЦИКЛОПЕНТА[D]ПИРИМИДИН-1-ИЛ)-N-ФЕНИЛАЦЕТАМИДА

Способ получения 2-(3-циклогексил-2,4-диоксо-2,3,4,5,6,7-1H-циклопента[d]пиримидин-1-ил)-N-фенилацетамида: из 3-циклогексил-6,7-дигидро-1H-циклопента-[d]-пиримидин-2,4-(3Н,5Н)-диона. Реакцию проводят с хлор-1Н-фенилацетамидом в присутствии этилата натрия в одну стадию.

DERIVED From ACID TETRAZOLE-5-CARBOXYLIQUE AND THEIR PREPARATION

SULPHAMOYLBENZOIC ACID AMIDES

NEW BENZIMIDAZOLS

SULPHAMOYLBENZOIC ACID AMIDES

NOUVEAUX BENZIMIDAZOLS

Substituted arylpyrazoles

This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

METHOD FOR PRODUCING TRIARYLORGANOBORATES

The invention relates to a method for producing triarylorganoborates from organoboronic acid esters in the presence of an n-valent cation 1/n Kn+, comprising the anhydrous treatment of the reaction mixture, and to the use of the obtained triarylorganoborates as coinitiators in photopolymer formulations, holographic media and holograms. The claimed method includes providing an alkyl or cycloalkylboronic acid ester of formula B-R'(OR2)(OR3) in an aprotic solvent in the presence of a metal, adding the aryl halide to produce an organometallic compound in situ, adding a ligand for the ion exchange and separation of the produced metal salts and solids (formula (A)). Triarylalkylborates of formulas (C) and (CC) are also claimed.

MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS

The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.

Indolyl amino acids useful as antihypertensive agents

A compound of the formula possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.

ANALYSIS OF MASS SPECTRAL DATA IN THE QUIET ZONES

SUBSTITUTED BENZAMIDES

NEW 2,4-DINITRO ANILINES USEFUL AS HAIR DYES

... 2,4-Dinitro-6-hydroxyalkylanilines of formula (I> wherein: X is an unsubstituted or a mono- or polyhydroxy substituted branched or unbranched alkylene of 2 to 6 carbon atoms; R is hydrogen, (C1-4)-alkyl, mono- or polyhydroxy-(C1-4)-alkyl, amino-(C1-4)-alkyl or mono- or disubstituted amino-(C1-4)-alkyl wherein each substituent is (C1-4)-alkyl, mono- or polyhydroxy (C1-4)-alkyl or the nitrogen atom and at least one substituent form part of a heterocyclic system; R' is hydrogen or (C1-4)-alkyl; or cosmetically acceptable salts of such compounds containing a salifiable amine group are useful as direct dyes for human hair.

ASSAYS UTILIZING IMPROVED CHEMILUMINESCENT ESTERS,THIOESTERS,THIOESTERS AND AMIDES

In accordance with the present invention, specific binding assays are disclosed which utilize an chemiluminescent compound, i.e., moiety, which has increased stability in aqueous solution. The chemiluminescent moiety is an ester, thioester or amide in which the ester, thioester or amide linkage is between (1) a heterocyclic ring or ring system containing a carbon atom to which the linkage is attached, wherein the heteroatom within the heterocyclic ring or ring system is in an oxidation state which renders such carbon atom susceptible to attack by peroxide or molecular oxygen to form an intermediate which decays to produce chemiluminescence, and (2) an aryl ring or ring system. The aryl ring or ring system contains at least one substituted six-member ring. The substituted six-member ring has two or more substituent groups, where at least two of said two or more substituent groups sterically hinder hydrolysis of said linkage. One or more of the substituent groups which sterically hinder hydrolysis ...

FOR TESTS USABLE ONES CHEMILUMINESZIERENDE ESTERS, THIOESTER AND AMIDES

PROCEDURE AND HYDANTOIN INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF BEING AWAKE AROUND HORMONE SECRETION PROMOTERS

ANALYSIS OF MASS SPECTRAL DATA IN THE CALM AREAS

VERFAHREN ZUR HERSTELLUNG VON NEUEN 4-NITRO-2-TRICHLORMETHYLPHENYLDISULFIDEN

VERFAHREN ZUR HERSTELLUNG NEUER HETEROCYCLISCHER ANTICHOLINERGISCHER SUBSTANZEN

VERFAHREN ZUR HERSTELLUNG VON ACYLCYANIDEN

PROCEDURE FOR THE PRODUCTION OF ECYL CYANIDES

NEW 12-AMINO-PYRIDAZINO (4 ', 5 ': 3,4>PYRROLO (2,1A>ISOCHINOLINE, PROCEDURE FOR YOUR PRODUCTION AND YOUR USE.

PROCEDURE FOR THE PRODUCTION OF NEW UREA AND AMIDO CONNECTIONS

SUBSTITUTED N-PROPARGYL-ANILINE, PROCEDURE FOR YOUR PRODUCTION AS WELL AS YOUR USE AS FUNGICIDES.

NEUE SUBSTITUIERTE BENZAMIDE, VERFAHREN ZU IHRER HERSTELLUNG UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN, DIE DIESE BENZAMIDE ENTHALTEN

PROCEDURE FOR THE PRODUCTION OF NEW PYRIDAZINDERIVATE AND THEIR SOUR ADDITION SALTS

PROCEDURE FOR the PRODUCTION OF NEW ONES 2-AMINO-5-SULFAMOYLBENZOESAUREAMIDEN AND YOUR SALTS, AS WELL AS OF OPTICAL ISOMERS OF it

PROCEDURE FOR THE PRODUCTION OF ECYL CYANIDES

PROCEDURE FOR the PRODUCTION OF NEW ONE 4-NITRO-2-TRICHLORMETHYLPHENYLDISULFIDEN

FLUOROALKYXYPHENYL-SUBSTITUTED NITROGEN HETEROCYCLES

4-NITRO-2-TRICHLOROMETHYLPHENYL DISULFIDES

SUBSTITUTED N-PROPARGYL-ANILINES AND THEIR USE AS FUNGICIDES

ANALYSIS OF MASS SPECTRAL DATA IN THE QUIET ZONES AND LABEL SELECTION THEREFOR

... ²² Provided are methods of identifying quiet zones in mass spectral data. The ²methods comprise, for example, summing the intensity of a representative ²number of fragmentation spectra obtained for a selected analyte. Also²provided are methods of selecting a label for an analyte, such that the label ²produces a mass spectrometric signal in a quiet zone.²² ...

METHOD FOR CROSS-LINKING RUBBER

TREATMENT OF EYE DISEASES

ПРОИЗВОДНЫЕ N-АЦИЛ-2,3-БЕНЗОДИАЗЕПИНА, ДЕЙСТВУЮЩИЕ НА ЦЕНТРАЛЬНУЮ НЕРВНУЮ СИСТЕМУ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ

Разработаны новые соединения на основе бензодиазепина, которые обладают значительным воздействием на центральную нервную систему, в частности, способностью вызывать релаксацию мышц. Особенность настоящего изобретения состоит в том, что новое производное бензодиазепина не обладает мутагенным действием.

3-(4-ЭТОКСИФЕНИЛ)-6-ОКСО-8-ФЕНИЛ-3,4-ДИГИДРО-2Н,6Н-ПИРИМИДО[2,1-B][1,3,5]ТИАДИАЗИН-7-КАРБОНИТРИЛ

... 3-(4-Этоксифенил)-6-оксо-8-фенил-3,4-дигидро-2H,6H-пиримидо[2,1-b][1,3,5]тиадиазин-7-карбонитрил .

Process for preparing pharmaceutical composition containing N-acyl-2,3-benzodiazepine derivatives as active ingredient

NEW BENZIMIDAZOLS

PROCEEDED OF PRODUCTION OF CYANIDES Of ACYLE USE AS RAW MATERIALS FOR the SYNTHESIS Of WEEDKILLERS

BENZOTHIAZINE DIOXIDES

AGENTS ANTI-HYPERTENSIFS

L'invention concerne des composés chimiques nouveaux. Il s'agit de nouveaux dérivés de phénylalanine. Ces composés sont utiles comme médicaments.

PROCESS PRA COMPOSITE ATTAINMENT NEW HETEROCICLICOS NITROGENADOS, SUBSTITUIDOS WITH FLUORALCOXIFENILA, INHIBITING COMPOSITIONS OF THE GROWTH AND PROCESS TO INHIBIT GROWTH INTERNODAL OF PLANTS

COMPOSTOS,PROCESSOS PARA A PREPARACAO DOS MESMOS E PARA EXTERMINAR OU CONTROLAR PRAGAS DE INSETOS OU ACAROS E COMPOSICAO INSETICIDA OU ACARICIDA

COMPOUNDS AND THERAPEUTIC USES THEREOF

The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, diseases associated with over production of IL12/IL23, lysosomal storage disorders, filovirus infections, ischemia, and other complications associated with these diseases and disorders.

ANALGESIC AND ANTIPRURITIC PHARMACEUTICAL COMPOSITION AND APPLICATION METHOD THEREFOR

An analgesic and antipruritic pharmaceutical composition and an application method therefor, relating to the technical field of medicinal chemistry. It is found in the study that an analgesic effect generated by independently inhibiting activity of Nav1.7 or Nav1.8 reduces along with the time course of peripheral nerve injury, and it is found that a mouse in neuropathic pain poorly responding to a Nav1.7 small molecule inhibitor shows good response to a Nav1.8 small molecule inhibitor. According to the discoveries, the analgesic effect of combination administration of different Nav1.7 inhibitors and Nav1.8 inhibitors is researched, and it is found that the combination administration of appropriate dosage of a Nav1.7 inhibitor PF-05089771 and a Nav1.8 inhibitor PF-04885614 can significantly improve the analgesic effect and increase the response rate to 100%. Therefore, a prescription of PF-05089771 and PF-04885614 can treat diseases caused by excessive activity relating to Nav1.7 or Nav1.8 ...

N-(2-ALKYL-3-MERCAPTOGLUTARYL)-AMINO-DIAZA CYCLOALKANONE DERIVATIVES AND THEIR USE AS COLLAGENASE INHIBITORS

Thiol carboxylic acid derivatives, processes for their preparation and their use as collagenase inhibitors are described.

Bis-o-amino(thio)phenols, and their preparation

The invention relates to novel bis-o-aminophenols, and bis-o-aminothiophenols of the following structure: см. иллюстрацию в PDF-документе where A1 to A6 are--independently of one another--H, F, CH3, CF3, OCH3, OCF3, CH2 CH3, CF2 CF3, OCH2 CH3 or OCF2 CF3, where at least one of the radicals A1 to A6 must be F or an F-containing group; T is O or S, and m is 0 or 1; and Z is a carbocyclic or heterocyclic aromatic radical.

Способ получения гуанидиновых производных или их солей с малеиновой кислотой

Способ получения гуанидиновых производнъ1х формулы о CF3CH2-NH, N-( (I) где п 4 или 5, или их солей с малеиновой кислотой, отличающийся тем, что осуществляют взаимодействие aN MHaKa X кислотой формулы CF CH -TSIH .0 г-м -1 (СН.гЪ- (IT) /L.-iN - -Naj V им. где п 4 или 5, о I с последуюид м выделением делевого IQ продукта в свободном виде или в виде СО соли с малеиновой кислотой.

Способ получения гетероциклических производных или их солей с кислотами

Изобретение касается гетероциклических производных, в частности соединений общей формулы 1: ,F,C-CH,-NH-C(NH,).(CH,)-C (NHR2)NR, где X - 1,2,3-триазол, или пиразол; R, и R связаны между собой с образованием незамещенного имидазольного или 5-метил-1,2,4-три- азольного кольца, или их солей с кислотами, которые являются антагонистами гистамина Н-2, ингибируют секрецию желудочного сока и исполь- зуютйя в медицине. Для выявления активности среди соединений указанного класса получены новые I из соединения формулы II: F,C-CH2-NH-C(NH2) /-X- -(CH2).-C(OCHj)NH, где X указано вьше, и аминоацетальдегидо- диметилацеталя или гидразида уксусной кислоты в среде метанола при комнатной температуре с последующим кипячением реакционной массы Выделяют I в свободном виде либо в виде солей с кислотами. Испытания I показывают лучшее антагонистное действие, чем известного циметидина. 1 табл. i О) оо а СП а 1с сн ...

Состав для ингибирования роста растений

Für Tests verwendbare chemilumineszierende Ester, Thioester und Amide

Neue N(6)-Aralkyl-adenosin-Derivate und Verfahren zur Herstellung derselben

Heterocyclic fluoro-alkoxy-phenyl derivs - of 2-pyrazine-3-pyridine-or 5-pyrimidine methanol, herbicides and plant fungicides

The novel title cpds. are of formula (I): (where R is 2-pyrazinyl, 3-pyridyl or 5-pyrimidyl, R1 is phenyl, pyridyl, 1-12 C alkyl or 3-8 C cycloalkyl, and R2 is trifluoromethoxyphenyl, tetrafluoroethoxyphenyl, pentafluoroethoxyphenyl, 3,4-(difluoromethylenedioxy)phenyl or 2,2,4,4-tetrafluoro-1,3-benzodioxamyl), including their non-phytotoxic acid addn. salt. They are prepd. by reacting novel ketones of formula R1COR2 with R-Hal, in the presence of an alkyl alkali at -70 degrees C, and they are esp. suitable for use as plant growth regulators at the rate of 0.14-5.6 kg/ha.

Assays utilizing chemiluminescent esters, thioesters and amides

Chemiluminescent moieties useful as labels in assays and immunoassays, and compositions and assay kits incorporating the moieties are described. The chemiluminescent moieties are of the type wherein attack by peroxide or molecular oxygen results in an electronically excited intermediate which decays with emission of light. The moieties are distinguished by being less prone to hydrolysis and thus exhibit greater stability.

NEW HETROCYCLIC COMPOUNDS

PROCEDURE FOR THE PRODUCTION OF ECYL CYANIDES

NICHTPEPTIDI RENIN HEMMER.

Procedure for the production of new 3,4-Dihydro-2H-1,2-benzothiazin-1,1-dioxyden and their salts

PROCEDURE FOR THE PRODUCTION OF NEW FLUORALKOXYPHENYL SUBSTITUTING NITROGEN HETERO CYCLES AND YOUR SALTS

PROCEDURE FOR THE PRODUCTION OF NEW PYRIDAZINDERIVATE AND THEIR SOUR ADDITION SALTS

VERFAHREN ZUR HERSTELLUNG NEUER PYRIDAZINDERIVATE UND DEREN SAUREADDITIONSSALZE

SULFONAMIDES DERIVED FROM DIARYLMETHANES AND THEIR USES AS MEDICAMENTS

N(6)-ARALKYL ADENOSINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME