20-06-2013 дата публикации
Номер: US20130157982A1
The present invention relates to novel amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors. 2. A compound according to claim 1 , wherein:{'sup': 1', '10, 'Ris N or C—R;'}{'sup': '2', 'Ris optionally substituted aromatic heterocycle or optionally substituted cycloalkenyl;'}{'sup': 3', '11', '12', '13', '14, 'Ris O, N—R, CH—Ror S, —CR═CR—, —C(O) or —C≡C—;'}{'sup': '4', 'Ris H, optionally substituted aromatic heterocycle, optionally substituted non-aromatic heterocycle, optionally substituted cycloalkyl, optionally substituted cycloalkenyl or optionally substituted aryl;'}{'sup': '5', 'sub': 1-3', '1-3, 'Ris H, halogen, hydroxyl, —OCalkyl, or Calkyl;'}{'sup': '6', 'sub': 1-3', '1-3, 'Ris H, Calkyl, halogen, hydroxyl or —OCalkyl;'}{'sup': '7', 'sub': '1-6', 'Ris H or Calkyl;'}{'sup': '8', 'sub': '1-6', 'Ris H or Calkyl;'}{'sup': 9', '15, 'sub': 3', '2', '2', '3-6', '2, 'Ris —OPOH, —COOH, —P(O)(OH), —Calkyl, —S(O)OH, —P(O)MeOH, —P(O)(H)OH or —OR;'}{'sup': '10', 'sub': 1-6', '1-3, 'Ris H, Calkyl, halogen, hydroxyl or —OCalkyl;'}{'sup': '11', 'sub': '1-3', 'Ris H or Calkyl;'}{'sup': '12', 'sub': 1-3', '1-3, 'Ris H, Calkyl, halogen, hydroxyl, —OCalkyl or amino;'}{'sup': '13', 'sub': '1-3', 'Ris H or Calkyl;'}{'sup': '14', 'sub': '1-3', 'Ris H or Calkyl;'}{'sup': '15', 'sub': '1-3', 'Ris H or Calkyl;'}{'sup': 16', '17, 'L is CHR, O, S, NRor —C(O)—;'}a is 0, 1, 2, 3, 4 or 5;b is 0, 1, 2, 3, 4 or 5;c is 0 or 1;d is 0, 1, 2 or 3;{'sup': '16', 'sub': 1-3', '1-3, 'Ris H, Calkyl, —OCalkyl, halogen, hydroxyl or amino, and'}{'sup': '17', 'sub': '1-3', 'Ris H or Calkyl;'}with the provisos:{'sup': 3', '11', '17, 'a). when Ris O, N—R, or S, and b is 0 or 1 then L is not O, S, or NR; and'}{'sup': '9', 'sub': 3', '2', '2', '2, 'b). when Ris —OPOH, —COOH, —P(O)(OH), —S(O)OH, —P(O)MeOH or —P(O)(H)OH'}then d is not 0; and{'sup': 9', '15, 'c). when Ris ORthen d is not ...
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