Способ получения 6-метокси- -карбоксипенициллиной или их солей

Способ получения производных цефалоспорина или пенициллина

Способ получения производных 6-аминопенициллановой кислоты

ALPHA-CARBOXAMIDOBENZYLPENICILLINE, DEREN ESTER UND SALZE UND VERFAHREN ZU IHRER HERSTELLUNG

VERFAHREN ZUR HERSTELLUNG VON BETA-LACTAM-VERBINDUNGEN

Verfahren zur Herstellung von Arylchlorcarbonylketenen

PROCESS FOR THE PREPARATION OF PENAM DERIVATIVES

Verfahren zur Hydrolyse von Alpha-Carbobenzyloxy- und Alpha-Carboaryloxy-benzylpenicillinen

CARBOXAMIDO ACYL DERIVATIVES OF PENICILLIN

... 1413851 - (Carboxamido) - phenylacetamido-penicillins PFIZER Inc 30 Nov 1972 [28 Jan 1972] 55458/72 Heading C2C Novel -carboxamidobenzylpenicillin compounds having the general Formula (III) wherein R 1 is C 1-4 alkyl; substituted C 1-4 alkyl wherein the substituent is carboxy, carbamyl, cyano, chlorine, bromine, C 1-3 alkoxy or C 1-3 alkylthio; Z is -O-, or -SO 2 -; and R 2 is hydrogen or 1-(C 2-5 )- alkanoyloxy-(C 1-4 )alkyl, and base salts thereof when the penicillin is an acid, are prepared (1) when Z is -O-, by reacting a compound of formula (I) wherein R 2 is alkanoyloxyalkyl as defined above, with N-hydroxysuccinimide in the presence of a carbodiimide to give a novel intermediate of Formula (II) and reacting this compound with an O-substituted hydroxylamine of formula: in which R 1 is as previously defined, to give the required compound (III) in which R 2 is alkanoyloxyalkyl, and if desired, hydrolysing to convert R 2 to hydrogen and optionally converting the resulting acid into a ...

Preparation of 6a-methorcy-penicillins

A process for the preparation of a penam derivative of formula (I): (I) wherein RA is hydrogen or a group of formula (Ia): (Ia) wherein X is -CO2R1, or SO3R1; R is C1-6alkyl, aryl, or heterocyclyl; R1 is hydrogen, or a pharmaceutically acceptable salt-forming ion or ester-forming radical, and R2 represents hydrogen or a pharmaceutically acceptable salt-forming ion or in vivo hydrolyzable ester-forming radical; which process comprises reacting a compound of formula (II): (II) wherein RB is hydrogen, a removable amino blocking group, or a group of formula (IIa): (IIa) wherein Y is -CO2Rx or -SO3Rx; R is as defined with respect to formula (I) above; Rx represents an ester-forming radical, RY represents hydrogen, a salt-forming radical or a carboxyl-blocking group, and R3 represents an alkyl, benzyl, or aryl group; with methanol in the presence of copper ions; and thereafter if necessary carrying out one or more of the following steps: (i) removal of any blocking group; (ii) converting the ...

Process of obtaining new penicillin compounds.

Process of obtaining new penicillin compounds.

PROCEDURE FOR THE PRODUCTION OF NEW PENICILLIN DERIVATIVES

PROCEDURE FOR THE PRODUCTION OF NEW PENICILLIN DERIVATIVES

PROCEDURE FOR THE PRODUCTION OF NEW OF PENICILLIN DERIVATIVES

VERFAHREN ZUR HERSTELLUNG VON PENICILLIN- UND CEPHALOSPORINSAURE-DERIVATEN

VERFAHREN ZUR HERSTELLUNG VON CYANACETAMID- -DERIVATEN UND DEREN SALZEN

PROCEDURE FOR THE PRODUCTION OF NEW PENICILLIN DERIVATIVES

PROCEDURE FOR THE PRODUCTION OF NEW PENICILLINEN

PROCEDURE FOR THE PRODUCTION OF NEW MONO ESTERS OF ALPHA CARBOXYPENICILLINEN

PROCEDURE FOR THE PRODUCTION OF PENIZILLINDERIVATEN AND SO RECEIVED CONNECTIONS.

SALT OF 3-THIENYLMALONSAEURE AND PROCEDURE FOR the PRODUCTION OF 3-THIENYLMALONSAEURE.

Procedure for the production of new aryl ketene derivatives

PROCEDURE FOR THE PRODUCTION OF NEW PENICILLINE

PROCEDURE FOR THE PRODUCTION OF NEW ALPHA AMINOBENZYLPENICILLINDERIVATE

PROCEDURE FOR the PRODUCTION OF NEW ALFA SUBSTITUTING 2-ADAMANTYL-METHYLPENICILLINEN

PROCEDURE FOR the PRODUCTION of a NEW DERIVATIVE of the 6-TRICHLORACETAMIDOPENICILLANSAURE

VERFAHREN ZUR HERSTELLUNG NEUER PENICILLINDERIVATE

PENICILLINS AND CEPHALOSPORINS

PENICILLINS

SALT OF 3-THIENYLMALONIC ACID

PENICILLINS

CHEMICAL INTERMEDIATES

A class of ketenimine intermediates are prepared from 6-acylaminopenicillins having an .alpha.-carboxy substituent in the side-chain, and are useful in the preparation of 6.alpha.-methoxy-.alpha.-carboxy penicillins.

PROCESS FOR THE PREPARATION OF NEW PENICILLIN DERIVATIVES CONTAINING A HALOGENO-CARBONYL GROUP

2-OXO-1-PYRIDINYL PENICILLIN AND CEPHALOSPORIN DERIVATIVES

Novel ¢substituted(2-oxo-1-pyridinyl)acetylamino!-penicillin and cephalosporin derivatives are prepared which are useful antibacterial agents.

PENICILLINS

PROCESS FOR THE PRODUCTION OF 3-THIENYLMALONIC ACID

CHEMICAL INTERMEDIATES

PENICILLINS

METHOD FOR PRODUCING CHEMICAL COMPOUNDS

6.BETA.-SUBSTITUTED PENICILLANIC ACIDS AS .BETA.-LACTAMASE INHIBITORS

A 6.beta.-substituted penicillanic acid of formula (XII) or a pharmaceutically acceptable salt or ester thereof, wherein A and B are each hydrogen wherein the carbon atoms to which A and B are attached are linked by a single bond, or A and B together form a bond, wherein the carbon atoms to which A and B are attached are linked by a double bond, R1 is selected from the group consisting of a) hydrogen, b) a pharmaceutically acceptable salt and c) a pharmaceutically acceptable group selected from the group consisting of C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkenyl, allyl, aryl, aralkyl, aralkenyl, aralkynyl, heterocyclyl, heterocyclylalkyl, heterocyclylalkenyl, heterocyclylalkynyl and alkylheterocyclyl; wherein said group c) is unsubstituted or substituted with a substituent selected from the group consisting of fluoro, chloro, bromo, iodo, azido, nitro, monoalkyl substituted amino, dialkyl substituted amino, aryl substituted amino, alkanoylamino, arylcarbonylamino ...

Verfahren zur Herstellung von a-Carboxybenzylpenicillin

Procédé pour préparer des acylpénicillines

Procédé pour la préparation de l'a-carboxybenzyl penicilline

A-carboxy-a- thienyl or furyl -methylpenicillins - alpha(furyl or thienyl) methyl penicillin antibiotics

... (A) Penicillins (I) R = alkyl or aralkyl, possibly substd. in the ring X = -S or -O Preferred cpds. have X = - S and R = benzyl (B) Non-toxic salts of (I) including metal salts, ammonium and substd. ammonium salts. The new cpds. are valuable antibacterial agents; they may be used as feed additives in animal feeds, as agents for the treatment of mastitis in cattle and as therapeutic agents for poultry and animals, including man, in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria. They are also valuable intermediates in the prepn. of corresponding carboxy cpds. as described in Pat. 64/04384.

Procédé pour la préparation de pénicillines et céphalosporines

PROCEDE DE PREPARATION DES (ALPHA)-CARBOXYARYLMETHYL ET (ALPHA)-CARBOARYLOXYARYLMETHYL PENICILLINES.

VERFAHREN ZUR HERSTELLUNG VON 6-AMINO-PENICILLANSAEUREDERIVATEN.

(ALPHA)-CARBOXY-2-THIENYLMETHYLPENICILLINE ET (ALPHA)-CARBOXY-2-THIENYLMETHYLCEPHALOSPORINE, LEURS ESTERS ET LEURS SELS.

PROCEDE POUR LA PREPARATION DE L'(ALPHA)-(CARBO(5-INDANYLOXY))BENZYLPENICILLINE.

PROCEDE DE PREPARATION DE L'ACIDE 2-PHENYL-2-(5-INDANYLOXYCARBONYL)-ACETIQUE.

Penicillin derivs antibacterial

... (A) Penicillin derivs. (I) R = phenyl, substd. phenyl, furyl or thienyl. Preferred compounds have R = phenyl or 3-thienyl. (B) Non-toxic salts of A such as metal salts, ammonium- and substd. ammonium salts e.g. trialkylamines, procaine, dibenzylamine, N-benzyl-beta-phenethylamine, 1-ephenamine, N,N'-dibenzylethylenediamine, dehydroabietylamine, N,N'-bisdehydroabietylethylenediamine and other amines used for the forming of salts with benzylpenicillin. Anti-bacterial activity; where R = phenyl or 3-thienyl (I) are very active in the treatment of infections caused by Pseudomonas bacteria such as Ps.pyocyanea.

Orally active alpha-carboxyarlylmethyl-penicillins

Orally active alpha-carboxyarylmethyl-penicillins. N3A. Are prepared by treating 6-aminopenicillanic acid or a salt in an inert solvent with an arylmalonic acid ester. The reaction is carried out at temperatures between 0 and 50 degrees C at a pH 5 to 8.

(A) Penicillin derivs. R=phenyl, substd. phenyl, furyl or thienyl; R1=phenyl, substd. phenyl, naphthyl, substd. naphthyl or the group R"=H, alkyl, phenyl, halom

... (A) Penicillin derivs. of general formula (I): R=phenyl, substd. phenyl, furyl or thienyl; R1=phenyl, substd. phenyl, naphthyl, substd. naphthyl or the group R"=H, alkyl, phenyl, halomethyl or alkylsulphonylmethyl; X=halogen or a nitro-, alkoxy-, aryloxy-, aralkoxy-, alkylsulphonyl-, arylsulphonyl- or aralkylsulphonyl group; Y and Z are same or different H, halogen, methyl or ethyl When X=alkoxy or aralkoxy, Y + Z may be -O- The compounds (I) may be in L- or D-form or DL-mixtures. (B) Salts of (I) such as non-toxic metal salts, ammonium- and substd. ammonium salts, or non-toxic amine salts such as those with benzylpenicillin. The new derivs. are active against Gram-positive and Gram-negative bacteria and are valuable therapeutics and prophylactic against infections in animals, including man and poultry.

Verfahren zur Herstellung neuer Penicilline

Procédé de préparation de sels cristallins de métaux alcalins d' -carboxybenzylpénicilline

PROCEDURE FOR THE PRODUCTION OF NEW OF PENICILLIN DERIVATIVES.

PROCEDURE FOR MANUFACTURING NEW ONE, REACTIVE DERIVATIVES OF PENICILLIN AND THE CEPHALOSPORINSAEURE.

Process for the preparation of novel 4-oxo-1-pyridinylpenicillin and -cephalosporin derivatives

PROCEDURE FOR THE PRODUCTION OF KETENIMINEN AS PRELIMINARY STAGES TO PENICILLIN DERIVATIVES.

PROCEDURE FOR THE PRODUCTION OF NEW OF PENICILLIN DERIVATIVES.

PROCEDURE FOR THE PRODUCTION OF NEW OF PENICILLIN DERIVATIVES.

PROCEDURE FOR THE PRODUCTION OF NEW OF PENICILLIN DERIVATIVES.

PROCEDURE FOR THE PRODUCTION OF NEW OF PENICILLIN DERIVATIVES.

PROCEDURE FOR THE PRODUCTION OF BACTERICIDAL CONNECTIONS.

Process for the preparation of the sodium salt of the novel alpha-carbethoxy-1-adamantylmethylpenicillin

Process for the preparation of the sodium salt of novel penicillins

BETA LACTAM INTERMEDIATE CONNECTIONS AS WELL AS PROCEDURES FOR YOUR PRODUCTION.

BETA LACTAM CONNECTIONS, PROCEDURES FOR YOUR PRODUCTION AS WELL AS THESE CONNECTIONS ABSTENTION PHARMACEUTICAL PREPARATIONS.

PROCEDURE FOR THE PRODUCTION OF CYANACETAMID DERIVATIVES OF ANTIBIOTICS.

PROCEDURE FOR THE PRODUCTION OF NEW OF PENICILLIN DERIVATIVES.

Ticarcillin disodium hydrate and preparation method as well as application thereof

PROCESS FOR THE PREPARATION OF OXAZOLIDINE COMPOUNDS FROM 6-AMINOPENICILLANIC ACID AND NEW PRODUCTS SO PRODUCED

PENICILLINS

2-OXO-1-PYRIDINYL PENICILLIN AND CEPHALOSPORIN DERIVATIVES

.beta.-lactames dérivés de l'acide pénicillanique, leur préparation et leurs utilisations thérapeutiques.

DERIVES DE L'ACIDE PENICILLANIQUE, LEUR PREPARATION ET LEURS UTILISATIONS THERAPEUTIQUES. CES COMPOSES REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN GROUPE PHENYLE, 4-HYDROXYPHENYLE, 1,4-CYCLOHEXADIENYLE OU 3-THIENYLE; R REPRESENTE UN GROUPE AMINO PRIMAIRE OU CARBOXY; R REPRESENTE UN ATOME D'HYDROGENE OU UN RADICAL ALKYLE INFERIEUR, ARYLE OU ARALKYLE; ET A REPRESENTE UN RADICAL D'UN INHIBITEUR DES B-LACTAMASES CONTENANT UN CYCLE B-LACTAME ET UN GROUPE CARBOXY, A ETANT RELIE PAR L'INTERMEDIAIRE DU GROUPE CARBOXY, ET LES SELS DES COMPOSES DE FORMULE I ET D'ACIDES OU BASES NON TOXIQUES ACCEPTABLES POUR L'USAGE PHARMACEUTIQUE. CES COMPOSES SONT DES ANTIBIOTIQUES UTILES DANS LE TRAITEMENT DES MALADIES INFECTIEUSES.

Method of preparation of penicillins

4-OXO-1-PYRIDINYL PENICILLIN AND CEPHALOSPORIN DERIVATIVES

PROCEDE DE PREPARATION D'OXAZOLINOAZETIDINONES A PARTIR D'ACIDE 6-AMINOPENICILLANIQUE ET NOUVEAUX PRODUITS AINSI OBTENUS

Procédé de préparation de composés d'azétidinone et nouveaux produits ainsi obtenus. Ces composés sont représentés par la formule : ...

Semi-synthetic penicillin prepn - from natural penicillins via the imino-ether

ALPHA-CARBOXYARYLMETHYL- AND ALPHA-CARBOARYLOXYARYLMETHYL PENICILLINS

Antibacterial 6-acyl APA cpds - 6-(2-(thienyloxycarbonyl)-2-(hetero)aryl-acetamido) Penicillanic acids