ФОСФОНАТНЫЕ СОЕДИНЕНИЯ

Изобретение относится к новым биологически активным фосфонатным соединениям. Описывается фосфонатное соединение, имеющее структуру где R1 и R1' независимо представляют собой -Н, возможно замещенный -O(С1-С24)алкил, -O(C1-С24)алкенил, -O(С1-С24)ацил, -S(С1-С24)алкил, -S(С1-С24)алкенил или -S(С1-С24)ацил, где по меньшей мере один из R1 и R1' не представляет собой -Н и где указанные алкенил или ацил возможно имеют от 1 до примерно 6 двойных связей; R2 и R2' независимо представляют собой -Н, возможно замещенный -O(С1-С7)алкил, -O(С1-С7)алкенил, -S(С1-С7)алкил, -S(С1-С7)алкенил, -O(C1-C7)ацил, -S(С1-С7)ацил, -N(С1-С7)ацил, -NH(С1-С7)алкил, -N((С1-С7)алкил)2, оксо, галоген, -NH2, -ОН или -SH; R3 представляет собой фосфонатное производное нуклеозида или бифосфонат; Х представляет собой L представляет собой валентную связь или бифункциональную связующую молекулу формулы -J-(CR2)t-G-, где t равно целому числу от 1 до 24, J и G независимо представляют собой -О-, -S-, -С(O)O- или -NH-, a R представляет ...

СПОСОБ ПОЛУЧЕНИЯ 2,3-ФУЛЛЕРО[60]-7-ФЕНИЛ-7-ФОСФАБИЦИКЛО[2.2.1]ГЕПТАНА

Способ получения 2,3-фуллеро[60]-7-фенил-7-фосфабицикло[2.2.1]гептана общей формулы (1)характеризующийся тем, что фуллерен Свзаимодействует с фенилфосфоланом общей формулы, при мольном соотношении С:фенилфосфолан 0,01:(0,01-0,011), в присутствии катализатора титаноцендихлорида CpTiCl, взятого в количестве 15-25 мол.% по отношению к фуллерену С, в среде толуола в качестве растворителя, при температуре 140-160°С в течение 4-8 ч.

СПОСОБ ПОЛУЧЕНИЯ МЕТИОНИНА СУЛЬФОКСИМИНА ИЛИ ЕГО ФОСФОРНОКИСЛОЙ СОЛИ

Изобретение относится к способу получения метионина сульфоксимина или его фосфорнокислой соли, которые используются в качестве кормовых добавок в рационах сельскохозяйственных животных и птиц, а также биологически активного вещества в фармацевтической отрасли. Способ получения метионина сульфоксимина или его фосфорнокислой соли включает взаимодействие метионина сульфоксида с азотистоводородной кислотой с последующей нейтрализацией реакционной смеси, фильтрованием от солей и упариванием воды и отличается тем, что к смеси 85%-ной ортофосфорной кислоты и пентоксида фосфора или к полифосфорной кислоте добавляют метионина сульфоксид и азид натрия, при этом азотистоводородная кислота образуется в результате реакции азида натрия со смесью 85%-ной ортофосфорной кислоты и пентоксида фосфора или с полифосфорной кислотой, нейтрализацию реакционной среды гидроксидом или карбонатом кальция ведут до рН 8-11 и получают метионина сульфоксимин или нейтрализацию реакционной смеси ведут до рН 6-7 и получают ...

Способ получения фосфорилированного дицианамида

Способ получения 2,6-дихлор-2,4,4, 6,8,8-гексафенилциклотетрафосфазена

Способ получения изоцианиддихлоридов тиофосфорной кислоты

Способ получения -окиси 1-нитро-9-(диалкиламиналкиламин)-акридина

Способ получения изоцианатов фосфора

Способ получения фосфор-органических соединений

Способ получения фосфорилстаннилкарбаматов

Способ получения диалкиловых эфиров изоцианатофосфорной кислоты

Способ получения диалкил-[(диалкилфосфоно) - (алкил или арил)метил]-N-(арил или ацил)-имидофосфатов

Способ получения производных изоцианатофосфорной кислоты

Способ получения диоргано (тио)фосфорилсульфен (тио)-мочевин

Гербицид

Гербицидная композиция

Средство борьбы с насекомыми и клещами

ORGANOZINNVERBINDUNGEN UND IHRE VERWENDUNG

OPTISCH AKTIVE DIPHOSPHINE UND HERSTELLUNGSVERFAHREN DURCH AUFTRENNUNG DER RACEMATMISCHUNG

Schmieroel fuer Verbrennungskraftmaschinen

Verfahren zur Herstellung von Zinnkomplexsalzen

O-PHOSPHATOXIME UND PESTICIDE

VERFAHREN ZUR HERSTELLUNG VON PALLADIUMPHOSPHINKOMPLEXEN

Verfahren zur Herstellung von Estern anorganischer Saeuren

Neue Diphosphinverbindung, Zwischenprodukte für deren Herstellung, Übergangsmetallkomplex enthaltend die Verbindung als Ligand und Katalysator für asymmetrische Hydrierungen, welcher den Komplex enthält

Schmiermittel

NICHT-LINEARES POLYMERISAT ALS KATALYSATORVORLAEUFER UND DEREN VERWENDUNG IN EINER KATALYSATORZUSAMMENSETZUNG

ABTRENNUNG VON NICKEL(0)-KOMPLEXEN UND PHOSPHORHALTIGEN LIGANDEN AUS NITRILGEMISCHEN

DURCH METALL-LIGANDCOMPLEXE KATALYSIERTE HERSTELLUNGSVERFAHREN

Stabilisierte Dithiophosphorsäuredisulfide

Organisches elektronisches Bauelement, Verwendung eines p-Dotierstoffs für ein Matrixmaterial

Es wird ein organisches elektronisches Bauelement angegeben. Das Bauelement umfasst ein Matrixmaterial, das als p-Dotierstoff ein organisches Phosphan enthält. Das organische Phosphan ist mit zumindest einem Halogenatom substituiert.

DERIVATIVE OF CREATINOL-O-PHOSPHATE HAVING THERAPEUTICAL ACTION, PROCESS FOR THE PREPARATION THEREOF AND RELATED PHARMACEUTICAL COMPOSITIONS

CHIRALE PHOSPHINE, DEREN KOMPLEXE MIT ÜBERGANGSMETALLEN UND DEREN VERWENDUNG IN ASYMMETRISCHEN SYNTHESEREAKTIONEN

VERFAHREN ZUR HERSTELLUNG VON DREIWERTIGEN ORGANOPHOSPHOR-VERBINDUNGEN

Verfahren zur Herstellung von Aldehyden

Schmieroel

VERFAHREN ZUR WIEDERGEWINNUNG VON KATALYSATOREN AUS HYDROCYANIERUNGSPRODUKTGEMISCHEN

VERBESSERN DER FAERBEEIGENSCHAFTEN UND VERMEIDEN DER VERFAERBUNG POLYMERER ORGANISCHER STOFFE

Verfahren zur Herstellung von 9,10-Dihydro-9-oxa-10-organyl-phosphaphenanthren-10-oxid und an den Phenylgruppen substituierten Derivaten desselben

Die Erfindung betrifft ein Verfahren zur Herstellung von 9,10-Dihydro-9-oxa-10-organylphosphaphenanthren-10-oxid und an den Phenylgruppen substituierten Derivaten desselben, bei dem: DOLLAR A (a) 9,10-Dihydro-9-oxa-10-phosphaphenanthren-10-oxid oder ein Derivat desselben in Gegenwart von mindestens einem ein- oder mehrwertigen Alkohol mit mindestens einem Orthocarbonsäureester unter Bildung eines ersten Zwischenprodukts umgesetzt wird, DOLLAR A (b) das Zwischenprodukt aus Stufe (a) gegebenenfalls mit mindestens einem weiteren ein- oder mehrwertigen Alkohol unter Bildung eines weiteren Zwischenprodukts umgesetzt wird und DOLLAR A (c) das Zwischenprodukt aus den Stufen (a) oder (b) durch Zugabe katalytischer Mengen Alkylierungsmittel in 9,10-Dihydro-9-oxa-10-organylphosphaphenanthren-10-oxid oder ein an den Phenylgruppen substituiertes Derivat desselben überführt wird.

PHOTOGRAPHISCHES AUFZEICHNUNGSMATERIAL SOWIE VERFAHREN ZUR HERSTELLUNG PHOTOGRAPHISCHER BILDER

Preparation of alkali and alkaline earth metal etherate salts

Vanadium hexacarbonyl may be prepared from an alkali or alkaline earth metal etherate salt containing the hexacarbonyl vanadate anion by treatment with a substantially nonvolatile non-oxidizing acid, preferably phosphoric acid. A large excess, generally 10 to 100 times the stoichiometric amount, of the acid is employed at about 25 DEG C. and preferably in the presence of an inert atmosphere or under vacuum. The ether present in the vanadium-containing salt should have a vapour pressure less than that of vanadium hexacarbonyl so that the latter may be sublimed off, under reduced pressure, in a highly pure state. Vanadium hexacarbonyl may also be prepared by the electrolysis of an aqueous solution of said vanadium-containing salt or by oxidation of said salt with an aqueous solution of ammonium and mercuric chlorides. Vanadium hexacarbonyl may be further reacted with nitric oxide in petroleum ether to form nitrosyl vanadium carbonyl.ALSO:The invention comprises (a) a process for preparing ...

THIONO-PHOSPHORIC-PHOSPHONIC ACID ESTERS ESTER AMIDES AND THEIR USE AS INSECTICIDES AND ACARICIDES

... 1354268 Pesticidal organo-phosphorus compounds: 4-iodo-phenols BAYER AG 19 Jan 1973 [20 Jan 1972] 2891/73 Headings C2P and C2C Novel compounds of Formula I where R is C 1-6 alkoxy or mono- or di-(C 1-6 alkyl) amino, R1 is phenyl, C 1-6 alkyl, mono- or di- (C 1-6 alkyl)amino or C 3-6 alkoxy and X is oxygen or sulphur may be prepared by reacting 4- iodophenol, in the presence of an acid-binding agent or in the form of an alkali metal or alkaline earth metal salt with a compound of Formula II where Hal is halogen. The starting material, 4-iodophenol, may be prepared by reacting diazotized 4-aminophenol with potassium iodide. The compounds of Formula I have pesticidal properties and may be used as the active ingredients in conventional pesticidal compositions for combating insects and acarids (including ectoparasites).

BONE SEEKING TECHNETIUM-99M COMPLEX

... 1435295 Radio-active substances RESEARCH CORP 19 Nov 1973 46064/75 Divided out of 1429549 Heading G6R The invention comprises a complex of technetium 99 m and tin-1-amino-ethane-1,1- diphosphonate. The complex may be made by mixing in aqueous solution a stannous salt, e.g. the chloride, sulphate, or acetate, 1-aminoethane-1,1-diphosphonic acid or a salt thereof, and a pertechnetate salt containing Tc99m. A solution of the complex is suitable for use by intravenous administration in skeletal imaging.

MANGANESE-II SALTS OF PHOSPHONIC ACID HALFESTERS

... 1369555 Manganese salts of phosphonic acid half esters CIBA-GEIGY AG 29 Sept 1972 [30 Sept 1971] 45126/72 Heading C2P [Also in Division C3] The invention comprises manganese (II) salts of the general formula wherein R1 is C 1 -C 18 alkyl, cyclohexyl, C 4 -C 10 aryl which may be substituted by 1 or 2 methyl groups, or is C 7 -C 11 aralkyl, A(-) is the anion of an aliphatic carboxylic acid having 1 to 18 carbon atoms or of a C 7 -C 11 aromatic or arylaliphatic carboxylic acid, or is the Cl, Br or I anion, x is 1 or 2, y is 0 or 1, x+y is 2, and R 2 is C 1 -C 18 alkyl. They are obtained by reacting 1 or 2 mols. of a compound with 1 mol. of a compound Mn++(A(-)) 2 or by reacting 2 mols. of R 1 -P(O)(OR2)(OH) with 1 mol. of manganese (II)-carbonate or hydroxide, the products in the latter method being those in which y in the formula is 0. The reactions are preferably carried out in an inert gas atmosphere, e.g. of nitrogen, and are generally effected ...

Improvements in or relating to lubricating compositions

Phosphorus- and sulphur-containing reaction products are prepared by reacting a phosphorus sulphide with a cyclic ketone having at least 12 carbon atoms. The ketone may be derived from the condensation of acetone to high molecular weight isophorone type fractions; the hydrogenated condensation products may also be used, and other ketones mentioned are dibutyl cyclohexanone, alkyl substituted carvomenthone, menthone, pulegone, carvone and camphor. The phosphorus sulphide may be phosphorus pentasulphide or heptasulphide. The molecular ratio of phosphorus sulphide to ketone may be from 1 : 2 to 1 : 1.2. The reaction product may be sulphurized, and before or after sulphurization may be treated with a metal compound, ammonia or an organic base to form a salt. Sulphurizing agents used may be sulphur, sulphur halides, alkali polysulphides, ammonium hydrogen sulphide and hydrogen sulphide. Metal compounds specified are the hydroxides, carbonates or oxides of the alkali, alkaline earth and heavy ...

METAL DERIVATIVES OF OXYACIDS

... 1406233 Polymer compositions containing metal derivatives of oxy acids IMPERIAL CHEMICAL INDUSTRIES Ltd 11 Sept 1972 [20 July 1971 29 Oct 1971 4 Nov 1971 26 Nov 1971 (2) 20 Dec 1971 2 June 1972] 34012/71 50354/71 51293/71 55001/71 55002/71 58999/71 and 25857/72 Headings C3P C3R and C3T [Also in Division C2] Liquid compositions comprise a compound of iron and/or titanium or iron and chromium; a compound of the formula X1X2PO(OH), where X1 and X2 are hydrogen, hydroxyl or halogen, or X2 may have the structure -OPO(X1)(OH); and a solvent comprising at least in part an organic component. In examples, compositions are described containing: partially condensed ethyl silicate (Example 19), tetraethyl silicate (Example 20), methyl triethoxysilane (Example 21), polyacrylic acid (Example 22), polyethylene oxide (Example 23), polyvinyl butyral (Example 24), polyvinyl acetate (Example 25), acrylonitrile-vinylidene dichloride copolymer (Example 26 ...

COMPLEXES CONTAINING PHSOPHORUS EXHAUST

... 1421136 Silylated rhodium phosphine complexes DOW CORNING Ltd 8 May 1973 [10 May 1972] 21784/72 Heading C3S The invention comprises rhodium (I) complexes of the formulae wherein X denotes Cl, Br or I, R1 denotes R 3 SiQ-, R denotes alkyl, aryl, aralkyl, alkaryl or (CH 3 ) 3 Si-, provided not more than one R denotes (CH 3 ) 3 Si-, Q denotes a C 1-6 divalent aliphatic hydrocarbon radical and R11 and R111 denote alkyl, aryl, aralkyl, alkaryl or R 3 SiQ-. Complexes in which X denotes chlorine may be prepared by reacting with PR1R11R111, by reacting rhodium (III) chloride with carbon monoxide in methanol and subsequently with PR1R11R111, or by reacting [RhX 3 (PR1R11R111) 3 ] with a primary alcohol in the presence of a base. Complexes in which X denotes bromine or iodine may be prepared by reacting the corresponding chlorine compounds with an alkali metal bromide or iodide. An example ...

PRODUCTION OF DIALKYLTHIOPHOSPHATES

... 1473010 Lubricants HOECHST AG 18 Dec 1974 [20 Dec 1973] 54613/74 Heading C5F [Also in Division C2] An oil and lubricant additive is a salt of formula [(R 1 O)(R 2 O)P(O)S] n M where R 1 and R 2 are C 1-6 alkyl, M is a metal cation and n is valency of M, which salt has been prepared by reacting a phosphite of formula (R 1 O)(R 2 O)P(O)H with an oxide of the metal or a mixture thereof with the corresponding carbonate or basic oxide, in the presence of pulverulent sulphur and one or more organic solvents at elevated temperature.

Organometallic electrolytes for the electrode position of various metals

In the electrolytic deposition of metals from organo-metal complexes, a suitable electrolyte for depositing Al, Zn, Ga, and In, is made by adding a compound of formula MeX1mRn to a compound of formula [R1R2R3R4Y]X2, where Me i Al, Zn, Ga, In, X1 and X2 are halogen, sulphate, cyanide, oxide or trifluoro methyl, R is alkyl of 1 - 6 C atoms, Y is N, P, Te, or As, and R1R2R3R4 of which one or more is phenyl, benzyl, aplobenzyl or strongly branched hydrocarbon of 3 to 12 C atoms and the remainder is alkyl of 1 - 4 C atoms. 1 to 2 mols of the metal complex is added to 1 mol of the second compound with solvents e.g. aromatic hydrocarbons or ethers if necessary. A typical product is [(CH3)3 (C6H5 CH2)N]F.2Al(C2H5)3, and is not spontaneously ignitable, or fuming in air. A table of examples of metal complexes is given with their conductivities. In examples, the aluminium complex diluted with toluene is used to plate copper, brass, nickel, or a molybdenum wafer at 2-5-3V with stirring. If toluene ...

LUBRICANT FOR A CONTROLLED-SLIP DIFFERENTIAL

... 1390755 Lubricants SUN OIL CO OF PENNSYLVANIA 18 Feb 1972 [19 Feb 1971 (2) 17 Jan 1972] 11323/74 Divided out of 1390051 Headings C5E and C5F A lubricant composition for a controlled-slip differential gear comprises (1) a surface active phosphate ester of a linear aliphatic ethoxylated alcohol and (2) a hydrocarbon base stock having a pnuematic viscosity at 210‹ F. of 1À5-200 cs. and containing a major amount of a blend of at least one C 13 -C 29 naphthene, and 0À1-20 wt. per cent of at least one of (a) a synthetic C 3 - C 8 polyolefin; (b) wholly or partially hydrogenated (a); (c) a hydrorefined naphthenic or paraffinic lube oil containing less than 1% of gel aromatic hydrocarbons. The amount of blend present in the base stock is sufficient to provide a greater coefficient of traction, measured at 600 ft./ min., 200‹ F. and 400,000 p.s.i., than would be provided by substitution of the same amount of ASTM Oil No. 3 for the blend. The lubricant may also contain a sulphurized blend of lard ...

Cleaning of solutions of alkyphosphates.

Solutions of alkylphosphates in hydrophobic organic solvents are cleaned by washing the solution with aqueous sulphuric acid, and contacting the washed solution with an ion exchange material. The ion exchange material may be a resin of the type designated as styrene divinyl benzene copolymers. The solutions are used in solvent extraction processes involved in the production of uranium.

DEODOURISING PRODUCTS COMPRISING ORGANIC TIOPHOSPHATE ESTERS

... 1279876 Deodorized thiophosphate pesticides CHEMINOVA AS 12 Dec 1969 [23 Dec 1968 31 Jan 1969] 60672/69 Heading A5E [Also in Division C2] A product comprising an organic mono- or dithiophosphate ester is deodorized by exposing it to the influence of a nitrogen oxide, a mixture of nitrogen oxides, or an inorganic or organic nitrite. Preferably the nitrogen oxide is N 2 O 4 and/or NO 2 although N 2 O, NO, N 2 O 3 and N 2 O 5 are also specified for use. After treatment with the nitrogen oxide air or other gas may be blown through the product to remove any remaining volatile substances present. The nitrogen oxide may be used in liquid form or in gaseous form when it may be mixed with air. The preferred nitrites for use in the process are alkali metal nitrites and alkyl nitrites e.g. ethyl nitrite, which may be formed in situ from a suitable nitrogen oxide, e.g. N 2 O 3 or N 2 O 4 and the requisite quantity of alcohol. The process is exemplified for the purification of O, O-dimethyl-S-(1, 2- ...

PESTICIDAL PHOSPHORUS-CONTAINING ESTERS

... 1361224 Phosphorus-containing esters of substituted hydroxy pyridines PEPRO SOC POUR LE DEVELOPPEMENT ET LAVENTE DE SPECIALITES CHIMIQUES 30 June 1971 [30 June 1970] 30661/71 Headings C2P and C2C The invention comprises esters of the general formula wherein R 1 is a C 1 -C 4 alkyl or -alkoxy radical or a halogenoalkyl, alkylamino, dialkylamino, phenyl or phenoxy radical, R 2 is a C 1 -C 4 alkyl or -haloalkyl radical, R 3 and R 4 which may be the same or different are selected from H, halogen (e.g. Cl, Br or I), NO 2 or CN but cannot both be hydrogen, and X is O or S. They may be obtained by reacting a chloride of the formula (R 1 )P(X)(OR 2 )Cl with an appropriately substituted 3-hydroxy-6-methyl pyridine in the presence of a hydrohalic acid acceptor or with a salt of the hydroxy pyridine derivative. The products have insecticidal, acaricidal and nematocidal properties and may be used as active ingredients in conventional pesticidal compositions. 2 - Chloro - 3 - hydroxy - 6 - methyl - ...

MANGANOUS SALTS OF DIALKYLHYDROXYBENZYL-PHOSPHONIC ACID HALF-ESTERS

... 1341137 Light-stabilized polyamides CIBAGEIGY AG 18 Oct 1971 [20 Oct 1970] 48437/71 Heading C3R [Also in Division C2] A polyamide is stabilized against the action of light by incorporating into it a compound of Formula I where R 1 and R 2 are C 1-8 alkyl, R 1 and R 2 together contain not more than 12 carbon atoms, A is the anion of a C 1-18 carboxylic acid or of a C 7-11 aromatic (including araliphatic) carboxylic acid or is a chloride, bromide or iodide anion, x is 1 or 2, y is 0 or 1, x + y is 2 and R 3 is C 1-18 alkyl. The polyamide may be nylon-6 or nylon-6,6, and the compound of Formula I is preferably added in an amount which corresponds to 1À0 to 500 ppm. of manganese relative to the polyamide. The polyamide composition may also contain pigments, chain regulators, antioxidants, UV-absorbers, antistatic agents and flameproofing agents. Reference has been directed by the Comptroller to Specification 1,081,825.

Process for the hydrogenation of organic compounds

Organic compounds are hydrogenated by contacting them with hydrogen in the presence of a catalyst comprising a cobalt complex of the formula HnCo(CO)z(ER3)x(R2ER1ER2)y in which x, y and z represent integers satisfying the equation x+2y+2=4, while x and z have values from 0 to 3 and y from 0 to 2; n is O or 1; E is a phosphorus or arsenic atom; R1 is a bivalent unsubstituted or halogen and/or alkoxy-substituted hydrocarbon group and each R represents a hydrogen atom or a univalent group corresponding to R1. The catalyst may be a mixture of such complexes in one of which n is O and in the other is 1. The compounds which may be hydrogenated may be, for example, unsaturated hydrocarbons which give more saturated hydrocains, saturated aldehydes and ketones which yield alcohols, unsaturated compounds such as cyanides to give saturated cyanides and unsaturated ketones which may give saturated ketones or saturated alcohols. In general temperatures between 50 DEG C. and 300 DEG C. are used. Examples ...

New lead complexes containing phosphorus and nitrogen

The invention comprises co-ordination complexes of a lead salt of a thio acid of phosphorus of the formula and wherein R and R1 are hydrocarbon or sub-stituted hydrocarbon radicals which may be the same or different, or taken together represent an alkylene radical which may be interrupted in the chain by a hetero atom such as oxygen or sulphur and which together with the remainder of the thio acid molecule forms a ring structure containing 8 to 10 atoms in the ring, and X is sulphur or oxygen with a heterocyclic tertiary amine selected from a group comprising heterocyclic tertiary amines in which one nitrogen atom is common to two rings and heterocyclic ditertiary amines in which the nitrogen atoms which may or may not be in the same ring and of which one may be exocyclic are separated from one another by either two or three carbon atoms. They may be obtained by mixing together solutions or suspensions containing appropriate stoichiometric ...

Insecticidal compositions

An insecticidal concentrate comprises (a) an insecticidal thiophosphate or thiophosphonate ester, (b) a compound having the general formula R-X-R1 in which X is an oxygen or sulphur atom, R is an alkyl group having at least 4 carbon atoms, a cycloalkyl group having 4 to 8 carbon atoms or an etherified alkylol group having a total of 4 to 18 carbon plus oxygen atoms, R1 is a hydrogen atom, an alkyl group, a cycloalkyl group having 4 to 8 carbon atoms or an etherified alkylol group having 4 to 18 carbon atoms, and (c) an ester of an acid of sulphur having the general formula R2-Y-R3 in which Y is a sulphite, sulphate or a sulphonate group, R2 is a hydrogen atom, an alkyl group having up to 18 carbon atoms or a monocyclic aryl or alkaryl group having up to 16 carbon atoms in the alkyl group and R3 is an alkyl group having up to 16 carbon atoms. Specified phosphate esters are O,O-diethyl-O-[2-(ethylthio)-ethyl] thiophosphate, O-ethyl-O-paranitrophenyl phenyl thiophosphonate, S-[1,2 - bis(carbethoxy ...

Process for the preparation of aldehydes and/or alcohols

An aldehyde and/or an alcohol is obtained by reacting an olefin with carbon monoxide and hydrogen in the presence of a complex containing in the molecule a transition metal having an atomic number from 23 to 32, 40 to 51, or 57 to 84 and at least one molecule of a biphyllic ligand containing trivalent phosphorus, arsenic or antimony as a catalyst. The preferred transition metals are iron, nickel, ruthenium, rhodium, palladium, osmium, iridium, platinum and, particularly, cobalt. A preferred class of catalysts are those having the formula [(Rz1A)x-L-Ry]pM(CO)n in which (Rz1A)x-L-Ry represents the biphyllic ligand, M is a transition element as defined above, L is phosphorus, arsenic or antimony, R and R1 are alkyl, aryl, aralkyl or alkaryl groups, A is oxygen, nitrogen or sulphur, x is 0-3, y is 3-x, p varies from 1 to the co-ordination member of the transition metal, n + p is equal to the co-ordination number and z is 1 where A is oxygen or sulphur or 2 when A is nitrogen. The olefines used ...

Purification process

PURIFICATION OF BIDENTATE ORGANOPHOSPHOROUS EXTRACTANTS

ORGANIC PHOSPHOROSILICON COMPOUND PROCESS FOR PRODUCTION THEREOF AND FLAMERETARDING POLYMER COMPOSITION CONTAINING SAME

... 1306553 Phosphorosilicon compounds TOYAMA CHEMICAL CO Ltd 25 March 1970 [19 May 1969] 14605/70 Addition to 1306554 Headings C3P and C3S Novel phosphorosilicon compounds of the formula wherein each A independently denotes unsubstituted or halogen-substituted C 1-4 alkyl, C 1-4 alkoxy, C 2-4 alkenyl, C 2-4 alkenoxy, C 6-8 aryl, C 6-8 aryloxy or benzyloxy, X and Y independently denote hydrogen, furyl, C 1-7 alkyl, C 2-7 alkenyl or C 6-8 aryl, RI - - - RII denotes unsubstituted or halogen-substituted C 2-3 alkylene, and n denotes an integer of from 1 to 4, are prepared by reacting a phosphorous acid triester of the formula (wherein T denotes unsubstituted or halogensubstituted C 1-3 alkyl), a carbonyl compound of the formula XCOY and a chlorinated silicon compound of the formula A 4-n SiCl n . The reactants undergo an Arbuzor rearrangement. Uses.-As flame-retarding agents for polyurethanes, polymethacrylates, polyesters, polyolefins, polystyrene, ethyl cellulose, nitrocellulose ...

Catalyst compositions containing transition metal complexes with thiolate ligands

Metal derivatives of dialkylhydroxyphenylalkylphosphonic acids and phosphonic acid half-esters

Various organic materials are stabilized by incorporating therein compounds of formula (I) [P]mMx[G]p wherein M is a metal or a metal alkyl having an available valence of from 1-4; G is an anion having an available valence of from 1-3 and P is of the formula and wherein z is 0-6, y is 1-4, n is 0-1, m is 1-3, x is 1-2, p is 0-3, n, m, p, and x being selected so as to satisfy the expression wherein r is the valence of the anion G. The group M consists either of a metal in full free valence state such as sodium, cadmium, zinc, barium, nickel, aluminium, tin, chromium, cobalt, iron, copper and titanium, or of a metal derivative in which part but not all of its full free valance state is satisfied by alkyl substitution, e.g. dialkyl tin. Materials which may be stabilized include lubricating oils of the aliphatic ester type, animal and vegetable oils, such as linseed oil, fat, tallow, lard, cod liver oil, castor oil, palm oil and cotton seed oil, ...

Metal Derivatives of Alkylhydroxyphenylalkyphosphinic Acids

... 1,162,465. Alkylhydroxyphenylalkyl phosphinic acids and salts and their use as stabilizers; organometallic compounds. J. R. GEIGY A.G. 29 Jan., 1968 [30 Jan., 1967], No. 4506/68. Headings C2C and C2J. [Also in Divisions C3 C5 and Dl] Novel phosphinic acid salts of the Formula I wherein M is a metal or metal complex cation having a valency n, R is an aliphatic, cycloaliphatic or aromatic radical containing up to 12 carbon atoms, z is 0 to 6, y is 1 to 4 and n is 1 to 4, are obtained by reacting the corresponding free phosphinic acids with compounds of the metal or metal complex, e.g. oxides or hydroxides, and, if desired, converting the products to other salts of the above formula by double decomposition and/or complex formation. The group M may be a metal complex in which some of the valencies of the metal are satisfied by one or more organic or inorganic moieties, e.g. C 1-30 carboxylic acyl, phenoxy, alkylphenoxy, alkyl, alkyl- and aryl-sulphate or sulphonate, or alkyl and aryl phosphonate ...

Processing stabiliser composition

Improvements relating to petroleum hydrocarbon products and the manufacture of addition agents therefor

Oxidation and deterioration of petroleum hydrocarbon products is inhibited by incorporating therein a small quantity of the reaction product of sulphur and phosphorus, or of a phosphorus sulphide with or without either or both of sulphur and phosphorus, with a compound having the formula ArXMT where Ar is an aromatic or substituted aromatic nucleus, X is a non-metal of Group 6 of the periodic table, M is a divalent metal of Group 2 of the periodic table and T is OH or (OM)n XAr where n is O, 1 or 2. The aromatic nucleus may be benzene, biphenyl, naphthalene or anthracene and may contain substituents such as the alkyl, aryl, carboxyl, hydroxyl, alkoxy, sulphhydryl, nitro, esterified carboxyl, keto, amino, aldehydo, chlormethyl, aminomethyl, alkyl thiomethyl, alkyl xantho methyl, metal substituted carboxyl, metal substituted hydroxyl or sulphhydryl groups or the halogens. Thus, the compound to be phosphorized and sulphurized may have the formula RArXMT where R represents at least one alkyl ...

A process for the manufacture of calcium salts of phosphorylated arabonic acid and derivatives thereof

Calcium salts of phosphorylated arabonic acid and derivatives thereof are obtained by treating arabonic acid lactone, arabonic acid, its salts or carboxyl esters with a phosphorylating agent and treating an aqueous solution of the product obtained with a calcium salt (including calcium hydroxide) to effect a double decomposition reaction with the said product and isolating the said calcium salts of phosphorylated arabonic acid or derivatives thereof from the mixture thus obtained. The monophosphoric acid obtained by the esterification of one molecule of arabonic acid with one molecule of phosphoric acid is preferred because it gives a calcium salt of calcium to phosphorus ratio of 2 : 1 which is also soluble within the pH range of stomach juice and hence is suitable for therapeutic purposes. Phosphorylating agents specified are phosphorus oxychloride, concentrated phosphoric acid and dibenzyl phosphate, although when the latter compound is used hydrogenation is necessary to remove the benzyl ...

A process for the deodorization of s-(1,2-dicarbethoxyethyl) o, o-dimethyl-dithiophosphate

S - (1,2 - dicarbethoxyethyl) - O, O - dimethyl dithiophosphate is deodorized by submitting it to the oxidizing action of an aqueous solution of a metal hypochlorite, preferably sodium hypochlorite, the treatment being carried out by agitating the dithiophosphate in a vessel while gradually adding thereto said hypochlorite solution, continuing the agitation for at least half an hour at a temperature not exceeing 50 DEG C., allowing the mixture to cool down to room temperature, removing the oxidized hypochlorite solution from the mixture by vacuum filtration, decantation or centrifugal action after allowing the mixture to settle, and finally removing residual moisture from the deodorized product. Preferably for 100 parts by volume dithiophosphate there are employed 50 parts by volume of a 4.7 to 5 per cent aqueous sodium hypochlorite solution. During the oxidizing action a current of air free from water but saturated with a mixture of nitrobenzene and amyl acetate may be passed through the ...

PHOSPHONIC ACID DIESTERS

... 1454001 Tertiary - alkoxysilyl phosphonic esters DYNAMIT NOBEL AG 29 Jan 1974 [31 Jan 1973] 04184/74 Heading C3S Tertiary-alkoxysilyl phosphonic esters of the formula wherein each R is a t-alkyl radical, each R1 is an aryl radical or an alkyl radical optionally interrupted by a hetero atom, and each R11 is an alkyl radical optionally interrupted by a hetero atom, a and b are each 0, 1 or 2 and a+b is 0, 1 or 2, may be made by reaction of the phosphite (R1O) 2 POH with a silane wherein Y is an alkenyl radical, in the presence of a free radical initiator. In examples the compounds and are prepared from dimethyl or diethyl phosphite and the corresponding vinyl or allyl trialkoxysilanes, in the presence of di-t-butyl peroxide at about 150‹ C. or 1,1-di-t-butoxy- 3,3,5-trimethylcyclohexane or t-butyl per-2- ethylhexoate at about 130‹ C.

METHOD OF PREPARING STABLE CONDENSATION PRODUCTS OF HALOGEN-CONTAINING PHOSPHATE AND/OR PHOSPHONATE ESTERS

... 1513575 Stabilizing condensation products of phosphorus oxyacid esters STAUFFER CHEMICAL CO 13 May 1975 [28 May 1974] 20087/75 Heading C2P [Also in Division C3] A stabilized condensation product of one or more pentavalent phosphorus oxyacid esters at least one of which is a #-haloalkyl phosphate or a B-haloalkyl ester of an organic phosphonic acid is obtained by treating the product at elevated temperature with an amount of alkylene oxide or other oxirane compound for a period of time after residual acidity has been neutralized, the said amount and period of time being effective to open labile groups present and to neutralize the thus formed groups. Specified condensation products are the homocondensation product of tris(2-chloroethyl, phosphate, the co-condensation product of bis(2-chloroethyl)vinyl phosphonate and dimethyl methyl phosphonate or trimethyl phosphate, the homocondensation product of bis(2-chloroethyl)vinyl phosphonate and the co-condensation product of tris(2-chloroethyl ...

PRODUCING SILYL PHOSPHATES

A process for the separation of monoalkyl phosphates from dialkyl phosphates

Monoalkyl phosphates are separated from dialkyl phosphates, the alkyl groups in the compounds containing not less than 5 and not more than 18 carbon atoms, by converting the mono- and di-alkyl phosphates into their alkali metal or alkaline earth metal salts, and dissolving the salts of the dialkyl phosphates from the mixture of salts so formed by extracting the mixture with one or more polar chlorinated hydrocarbons. The polar chlorinated hydrocarbons may be chlorinated aliphatic, -cyclo-aliphatic or -aromatic hydrocarbons, chloroform being especially suitable. With chloroform the extraction may be effected at normal temperatures but when using certain other chlorinated hydrocarbons it may be desirable to heat the mixture. The alkali metal and alkaline earth metal salts may be prepared by adding solutions of the bases derived from the metals to the products of the reaction between phosphorus pentoxide and aliphatic alcohols or in those cases in which the bases are only slightly soluble ...

Composition

Process for preparation of hiv protease inhibitors

Process for purifying aminomethylenephosphonic acids.

High purity ethylenediaminetetra (methylenephosphonic acid) and

Nucleoside phosphonate conjugates as anti HIV agents

PROCESSES FOR PURIFYING AMINOMETHYLENE PHOSPHONIC ACIDS

Process for preparation of HIV protease inhibitors

Process for preparation of hiv protease inhibitors

Nucleoside phosphonate conjugates as anti HIV agents

Process for preparation of HIV protease inhibitors

Derived organophosphoré from the isothiazole and proceeded of preparation.

Process of stabilization of agents of halogenation phosphite of triaryle-halogen.

Pesticides compositions.

Process for the preparation of organometallic complexes.

Fungicidal compositions containing fungicidal monoaminophosphites.

Method of preparation of derived from the epoxy-1,2-propylphosphonique acid.

Phosphorated compounds containing méthylpyridines substituted, preparation and application daN

Fungicidal compositions containing alcoylphosphites.

Process for purifying aminomethylenephosphonic acids.

Fungicidal compositions containing phosphonic esters.

Compositions containing phosphoric esters associated with one stabilizing.

METHOD OF PURIFYING ORGANIC DIPHOSPHITE COMPOUNDS

The present invention relates to a method of purifying organic diphosphite compounds. 131-. (canceled)33. The method of claim 32 , wherein the precipitated organic diphosphite is separated from the liquid phase claim 32 , and the precipitated organic diphosphite is subjected to washing with a liquid washing medium.34. The method of claim 32 , wherein the method comprises the steps ofa) providing a solution comprising the crude organic diphosphite of general formula (I) and (L1),b1) partly crystallizing out the organic diphosphite by distilling off part of (L1) and, to complete the crystallization, adding (L2), andc) separating off the crystallized organic disphosphite from the liquid phase.35. The method of claim 32 , wherein the method comprises the steps ofa) providing a solution comprising the crude organic diphosphite of the general formula (I) and (L1),b2) adding the solution provided in step a) to (L2), with the organic diphosphite at least partly precipitating, andc) separating off the precipitated organic diphosphite from the liquid phase.36. The method of claim 32 , wherein (L1) is selected from the group consisting of (C-C-alkyl)benzenes claim 32 , C-C-alkyl phenyl ethers claim 32 , chlorobenzene claim 32 , and mixtures thereof.37. The method of claim 32 , wherein (L1) is selected from the group consisting of toluene claim 32 , ethylbenzene claim 32 , o-xylene claim 32 , m-xylene claim 32 , or p-xylene claim 32 , anisole claim 32 , ethoxybenzene claim 32 , propoxybenzene claim 32 , isopropoxybenzene claim 32 , chlorobenzene claim 32 , and mixtures thereof.38. The method of claim 32 , wherein (L1) is toluene.39. The method of claim 32 , wherein (L2) is methanol claim 32 , ethanol claim 32 , ethylene glycol dimethyl ether claim 32 , or mixtures thereof.40. The method of claim 32 , wherein (L2) is methanol.45. The method of claim 32 , wherein the organic diphosphite of general formula (I) is 6 claim 32 ,6′-[[3 claim 32 ,3′ claim 32 ,5 claim 32 ,5′-tetrakis(1 ...

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL] PYRIMIDINE-2,4-DIAMINE

Crystalline forms of brigatinib, pharmaceutical compositions comprising the same, and methods of their preparation and use of the same are disclosed herein. 2. (canceled)3. The crystalline form of claim 1 , which is crystalline Form A of brigatinib.4. (canceled)5. The crystalline form of claim 3 , having an x-ray powder diffraction pattern substantially as shown in .6. The crystalline form of claim 3 , having an x-ray powder diffraction pattern with at least two peaks chosen from 6.1 claim 3 , 8.6 claim 3 , 9.6 claim 3 , 10.8 claim 3 , 11.3 claim 3 , 13.5 claim 3 , 14.3 claim 3 , 15.9 claim 3 , 17.2 claim 3 , 18.9 claim 3 , 19.4 claim 3 , 20.1 claim 3 , 21.8 claim 3 , 22.6 claim 3 , 23.1 claim 3 , 23.9 claim 3 , and 27.7 °2θ claim 3 , with a variance of ±0.3 °2θ.7. The crystalline form of claim 3 , having an x-ray powder diffraction pattern with at least two peaks chosen from 9.6 claim 3 , 17.2 claim 3 , 19.4 claim 3 , 20.1 claim 3 , 23.1 claim 3 , and 27.7 °2θ claim 3 , with a variance of ±0.3 °2θ.8. The crystalline form of claim 3 , which is anhydrous.9. The crystalline form of claim 3 , having an onset melting temperature of 214.5° C.10. (canceled)11. A process for preparing crystalline Form A of brigatinib comprising elevating the temperature of crystallization to 60° C. and adding an NaOH solution at a slow rate.12. The crystalline form of claim 1 , which is crystalline Form B of brigatinib.13. (canceled)14. The crystalline form of claim 12 , having an x-ray powder diffraction pattern substantially as shown in .15. The crystalline form of claim 12 , having an x-ray powder diffraction pattern with at least four peaks chosen from 5.7 claim 12 , 9.2 claim 12 , 11.5 claim 12 , 12.8 claim 12 , 14.5 claim 12 , 15.5 claim 12 , 16.9 claim 12 , 17.7 claim 12 , 19.2 claim 12 , 20.4 claim 12 , 21.8 claim 12 , 23.2 claim 12 , and 29.5 °2θ claim 12 , with a variance of ±0.3 °2θ.16. The crystalline form of claim 12 , having an x-ray powder diffraction pattern with at least ...

PENTAFLUOROPHOSPHATE DERIVATIVE, ITS USES AND AN APPROPRIATE MANUFACTURING METHOD

It is provided a pentafluorophosphate derivative according to general formula (I): 2. The pentafluorophosphate derivative according to claim 1 , wherein the cycloalkyl or the aryl is substituted by a hydrocarbon chain comprising an amide function and/or a carboxyl function claim 1 , or by a substituent chosen from the group consisting of alkyl claim 1 , alkylamino claim 1 , alkylaminocarboxy claim 1 , halogen claim 1 , haloalkyl claim 1 , carboxy claim 1 , alkoxycarbonyl claim 1 , hydroxy claim 1 , N-morpholino claim 1 , N-morpholinoalkyl claim 1 , N-morpholinocarbonyl claim 1 , N-methyl-N-piperazinyl claim 1 , N-methyl-N-piperazinylalkyl claim 1 , N-methyl-N-piperazinylcarbonyl claim 1 , and sulfo.4. The pentafluorophosphate derivative according to claim 3 , wherein the alkyl claim 3 , the cycloalkyl or the aryl is substituted by a hydrocarbon chain comprising an amide function and/or a carboxyl function claim 3 , or by a substituent chosen from the group consisting of alkyl claim 3 , alkylamino claim 3 , alkylaminocarboxy claim 3 , halogen claim 3 , haloalkyl claim 3 , carboxy claim 3 , alkoxycarbonyl claim 3 , hydroxy claim 3 , N-morpholino claim 3 , N-morpholinoalkyl claim 3 , N-morpholinocarbonyl claim 3 , N-methyl-N-piperazinyl claim 3 , N-methyl-N-piperazinylalkyl claim 3 , N-methyl-N-piperazinylcarbonyl claim 3 , and sulfo.6. The pentafluorophosphate derivative according to claim 1 , wherein Rand Rdenote F.7. The pentafluorophosphate derivative according to claim 1 , wherein Rand Rdenote F claim 1 , and Rdenotes H.8. (canceled)9. (canceled)10. (canceled)11. A pharmaceutical composition claim 1 , comprising a pentafluorophosphate derivative according to as active compound.13. The method according to claim 12 , wherein step a) is carried out by reacting the diethyl phosphonate derivative with bromotrimethylsilane in an organic solvent and by purifying the resulting product with an ion-exchange resin.14. The method according to claim 12 , wherein step b) is ...

PROCESSES FOR PURIFYING LIGANDS

Embodiments of the present invention are directed to processes for purifying ligands such as organopolyphosphite ligands. In one embodiment, a process comprises: (a) receiving a solid organopolyphosphite compound that has been recrystallized or triturated at least once, wherein the solid organopolyphosphite compound comprises greater than one weight percent of an oxidized phosphite impurity and wherein the organopolyphosphite compound is substantially free of solvent; (b) slurrying the solid organopolyphosphite compound in a Cor higher alcohol at a temperature of at least 60° C. for at least 20 minutes to reduce the oxidized phosphite impurity in the solid phase; and (c) removing liquid comprising dissolved oxidized phosphite impurity from the slurry, wherein the residual oxidized phosphite impurity content of the organopolyphosphite compound following step (c) is 1 weight percent or less. 1. A process comprising:(a) receiving a solid organopolyphosphite compound that has been recrystallized or triturated at least once, wherein the solid organopolyphosphite compound comprises greater than one weight percent of an oxidized phosphite impurity and wherein the organopolyphosphite compound is substantially free of solvent;{'sub': '2', '(b) slurrying the solid organopolyphosphite compound in a Cor higher alcohol at a temperature of at least 60° C. for at least 20 minutes to reduce the oxidized phosphite impurity in the solid phase; and'}(c) removing liquid comprising dissolved oxidized phosphite impurity from the slurry, wherein the residual oxidized phosphite impurity content of the organopolyphosphite compound following step (c) is 1 weight percent or less.2. The process of claim 1 , wherein the organopolyphosphite is an organobisphosphite.3. The process of claim 1 , wherein the dissolved oxidized phosphite impurity is removed by filtration.4. The process of claim 1 , wherein the dissolved oxidized phosphite impurity is removed by centrifugation.5. The process of claim ...

Process for reducing the chlorine content of organomonophosphites using two solutions

Process with universal usefulness for reducing the chlorine content of organomonophosphites, using two solutions.

Low iron hydrous phospholipid and method for separating low-iron hydrous phospholipids from soybean oil sediments

The invention belongs to the technical field of phospholipid processing, in particular to a low-iron hydrous phospholipid and a method for separating low-iron hydrous phospholipids from soybean oil sediments. The main components of low-iron water-containing phospholipids are phospholipids, oil and water; its water content is 70-80 g/100 g; on a dry basis, the content of acetone-insoluble matter is 92.5-95.5 g/100 g; in terms of acetone-insoluble matter, the iron content is less than or equal to 18 mg/kg. The low-iron water-containing phospholipid of the present invention is prepared from soybean oil by a hydration method, and is used to solve the defects of low acetone-insoluble content of the water-containing phospholipid, inability to remove iron ions and the industry's long-term dependence on the solvent method to prepare the powdered phospholipid; At the same time, the method solves the technical problem that “the preparation of powder phospholipid by hydration method cannot realize industrial production”.

PHOSPHONAMIDE ESTER COMPOUND, SALT THEREOF, RELATED CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to compounds represented by formula (I) and formula (II) and a chiral synthesis and chiral isolation method therefor, further relating to a salt and crystal form of the compound represented by formula (I), a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the preparation of a medicament used for the treatment of a viral infectious disease such as hepatitis B. 2. The salt of the compound of Formula (I) according to claim 1 , wherein the molar ratio of the compound of Formula (I) to the inorganic acid or the organic acid is 1:1 or 1:½ or 1:⅓ claim 1 , preferably 1:1.4. (canceled)5. A fumarate salt of the compound of Formula (I) according to claim 1 , wherein the molar ratio of the compound of Formula (I) to fumaric acid is 1:1 or 1:½ claim 1 , preferably 1:1.6. Crystalline form A of the fumarate salt of the compound of Formula (I) according to claim 1 , wherein{'figref': {'@idref': 'DRAWINGS', 'FIG. 1'}, 'the crystalline form A of the fumarate salt of the compound of Formula (I) has an XRPD pattern comprising characteristic peaks at diffraction angles (2θ) of 5.1±0.2°, 6.4±0.2°, 16.3±0.2°, 18.7±0.2°, and 28.2±0.2°; preferably comprising characteristic peaks at diffraction angles (20) of 5.1±0.2°, 6.4±0.2°, 14.7±0.2°, 15.3±0.2°, 16.3±0.2°, 18.0±0.2°, 18.7±0.2°, 19.2±0.2°, 28.2±0.2°, and 29.6±0.2°; more preferably comprising characteristic peaks at diffraction angles (2θ) of 5.1±0.2, 6.4±0.2°, 12.9±0.2°, 14.7±0.2°, 15.3±0.2°, 16.3±0.2°, 18.0±0.2°, 18.7±0.2°, 18.9±0.2°, 19.2±0.2°, 20.0±0.2°, 20.7±0.2°, 22.2±0.2°, 24.0±0.2°, 24.9±0.2°, 25.3±0.2°, 27.8±0.2°, 28.2±0.2°, and 29.6±0.2°; and most preferably comprising characteristic peaks as shown in ;'}particularly preferably, the crystalline form A of the fumarate salt of the compound of Formula (I) has the following cell parameters:Cell size:a=13.6818(8) Åb=6.3963(4) Åc=17.2967(13) Åα/°=90β/°=96.113(6)γ/°=90{'sup': '3', 'Cell volume: 1505.06 (17 ...

Hydrochloric acid stripping process for ionic liquid regeneration process

A method for regenerating deactivated acidic ionic liquid is described. The method involves reducing a level of free hydrochloric acid in the deactivated acidic ionic liquid in a removal zone using at least one of heat, a stripping fluid, reduced pressure, and liquid-liquid extraction to form a deactivated acidic ionic liquid having a reduced level of free hydrochloric acid; and regenerating the deactivated acidic ionic liquid having the reduced level of free hydrochloric acid.

Synthesis of Racemic Amphetamine Derivatives by Cuprate Addition Reaction with Aziridine Phosphoramidate Compounds

The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions. 2. (canceled)3. (canceled)4. (canceled)6. The process according to wherein the compound of Formula 6 contains less than 0.1% regioisomeric impurity.7. The process according to wherein the R=methyl claim 6 , ethyl claim 6 , isopropyl or phenyl.8. The process according to wherein the copper catalyst is CuCl claim 1 , CuCl claim 1 , CuBr claim 1 , CuF claim 1 , Cu(OAc) claim 1 , Cu(acac) claim 1 , Cu(OMe) claim 1 , Copper nanoparticles claim 1 , Copper turnings claim 1 , or combinations thereof.9. The process according to wherein the mixture of two or more solvents comprises a mixture of organic solvent and residual THF.10. The process according to wherein the solvent and temperature conditions effective to produce a compound of Formula 6 comprise an organic ether-toluene mixture claim 1 , or an organic ether selected from the group consisting of diethyl ether claim 1 , tetrahydrofuran claim 1 , 2-methyltetrahydrofuran and mixtures thereof.11. The process according to wherein the phenylmagnesium halide is either phenylmagnesium chloride claim 1 , phenylmagnesium bromide or phenylmagnesium iodide.12. The process according to wherein the phenylmagnesium halide solutions can either be commercially supplied or prepared in situ from the corresponding halobenzene and magnesium.13. The process according to wherein the magnesium can be in the form of chips claim 12 , granules claim 12 , ribbon claim 12 , turnings claim ...

Fluid treatment process

Non-aqueous functional fluids are treated to avoid degradation or to recondition degraded fluids by a process which comprises contacting the fluid with an anionic ion-exchange resin and subsequently removing water by vacuum dehydration. The fluids can be restored and maintained at a water content of less than 0.1 % w/w and an acid number of less than 0.2 mgKOH/gm. The fluid is preferably a triaryl phosphate based fluid. Treated fluids may exibit improved properties especially increased resistivity.

Synthesis of stable solutions of rare earth tris (organophosphate) in hydrocarbon solvents

Stable rare earth tris (organophosphate) solutions comprise a rare earth tris (organophosphate) and a hydrocarbon solvent. From about 2% to about 10% rare earth element, preferably from about 3% to about 8%, is present in the solutions. The rare earth tris (organophosphate) solutions are stable from precipitation of the rare earth tris (organophosphate) for at least about fifteen (15) days, preferably for at least about twenty (20) days and most preferably at least about thirty (30) days. A process for preparing these solutions is described herein. A stabilizing additive, acid, glycol or mixtures thereof, is utilized to inhibit precipitation. The molar ratios of free acid, glycol and/or water to the rare earth element are controlled to inhibit precipitation.

Halo derivatives of vanadium organophosphates

A composition having the general formula:

Photosensitive copper (i) complexes and the use thereof in photographic development

A novel copper (I) complex having the formula

Non-scorch flame retarded polyurethane foam

The present invention relates to phosphorous based flame retardants useful in polyurethane foam and foams comprising the phosphorous based flame retardants.

Non-scorch flame retarded polyurethane foam

The present invention relates to phosphorous based flame retardants useful in polyurethane foam and foams comprising the phosphorous based flame and retardants.

Coordination complexes of metal halides and pentavalent phosphorus compounds

无焦阻燃聚氨酯泡沫塑料

本发明涉及磷基阻燃剂，其在包含该磷基阻燃剂的聚氨酯泡沫塑料中是有用的。

Synthesis of stable solutions of rare earth tris (organophosphate) in hydrocarbon solvents

Stable rare earth tris (organophosphate) solutions comprise a rare earth tris (organophosphate) and a hydrocarbon solvent. From about 2% to about 10% rare earth element, preferably from about 3% to about 8%, is present in the solutions. The rare earth tris (organophosphate) solutions are stable from precipitation of the rare earth tris (organophosphate) for at least about fifteen (15) days, preferably for at least about twenty (20) days and most preferably at least about thirty (30) days. A process for preparing these solutions is described herein. A stabilizing additive, acid, glycol or mixtures thereof, is utilized to inhibit precipitation. The molar ratios of free acid, glycol and/or water to the rare earth element are controlled to inhibit precipitation.

Production method of α-chloro-phosphorylidene

Verfahren zur Herstellung von dreiwertigen Organophosphor-Verbindungen

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von Organophosphiten, Organophosphoniten und Organophosphiniten durch Kondensation von Phosphortrihalogeniden oder Organophosphorhalogeniden mit organischen, Hydroxy-Gruppen tragenden Verbindungen in Gegenwart von polymeren basischen Ionentauscherharzen. DOLLAR A Durch das erfindungsgemäße Verfahren ist die Herstellung von dreiwertigen Organophosphor-Verbindungen, welche z. B. als Liganden in Rhodiumkomplexen verwendet werden können, die als Katalysator in der Hydroformylierung eingesetzt werden können, einfach möglich.

醛的制备方法

一种醛的制备方法,该方法包括在反应区中在至少含铑和有机亚磷酸酯的铑配位催化剂的存在下使烯属化合物与一氧化碳和氢反应产生醛的反应步骤、从反应区中取出的反应溶液中分离出醛得到含铑配位催化剂的催化剂溶液的分离步骤以及将催化剂溶液循环到反应区中的循环步骤,按如此方式从反应溶液中分离出醛,使催化剂溶液中的醛浓度为0.5—99%重量。

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Process for purifying aminoethylenephosphonic acids for pharmaceutical use

내용 없음. No content.

Organo metallic compounds

ORGANO-METALLIC COMPOUNDS OF THE GENERAL FORMULA: LNM(CYM(M''R1R2R3)3-M)R WHERE M IS A TRANSITION METAL OF GROUP IV-A, V-A, VI-A, VII-A, VIII OR I-B OF THE PERIODIC TABLE OF THE ELEMENTS; M'' IS CARBON, SILICON, GERMANIUM, TIN, OR LEAD; WHERE M'' IS CARBON, R1, R2, R3 ARE ALKYL OR ARYL GROUPS AND MAY BE THE SAME OR DIFFERENT, AND WHERE M'' IS SILICON, GERMANIUM, TIN, OR LEAD, R1, R2 AND R3 ARE ALKYL, ARYL, ALKOXY, OR ARALKOXY GROUPS OR HALOGEN OR HYDROGEN ATOMS AND MAY BE THE SAME OR DIFFERENT; M IS 0, 1 OR 2; N IS 0 TO 4; LN IS THE SUM OF ALL OTHER LIGANDS (IF ANY) TO THE TRANSITION METAL, WHICH LIGANDS MAY BE THE SAME OR DIFFERENT; Y IS HYDROGEN, OR HALOGEN, OR AN ALKYL OR ARYL GROUP, AND WHEN M IS 2, THE TWO GROUPS Y MAY BE THE SAME OR DIFFERENT; R IS 1 TO 4 DEPENDING ON THE AVAILABLE VALENCIES OF THE TRANSISTION METAL. THE COMPOUNDS ARE USEFUL AS CATALYSTS FOR OLEFINE POLYMERISATION, ISOMERISATION AND OLIGOMERSATION, AND FOR HYDROGENATION, DEHYDROGENATION, HYDROFORMYLATION AND HYDROSILYLATION REACTIONS.

Process for producing aluminium monoethylphosphate

Aluminum monoethyl-phosphite, useful for the protection of plants against fungal diseases, is manufactured in a continuous manner by first preparing a mixture of phosphite compounds, containing at least 70 mol % of diethyl phosphite, then saponifying and neutralizing such mixture with an inorganic base, at a temperature of 20 DEG -85 DEG C., at a pH of 4.0-8.5, and finally reacting the residual aqueous solution of alkaline metal monoethyl-phosphite, continuously withdrawn from the preceding operation, with an approximately stoichiometric amount of a water-soluble aluminum salt at 70 DEG -95 DEG C. and a pH of 3.0-4.5.

Werkwijze voor het bereiden van een rhodium-fosfine- -hydrogeneringskatalysatorcomplex.

Novel Phosphoric Compound, Method of Preparing the Same and Flameproof Thermoplastic Resin Composition Using the Same

본 발명은 하기 화학식 1로 표시되는 새로운 인계 화합물, 그 제조방법을 제공한다. 하기 화학식 1로 표시되는 인계 화합물을 적용한 열가소성 수지 조성물은 난연성이 우수하고, 가공이나 연소 시 유독가스를 발생시키지 않아 친환경적이다.  The present invention provides a novel phosphorus compound represented by the following formula (1), a method for preparing the same. The thermoplastic resin composition to which the phosphorus-based compound represented by the following Chemical Formula 1 is applied is excellent in flame retardancy, and does not generate toxic gas during processing or combustion, thereby being environmentally friendly. [화학식 1] [Formula 1] 상기 화학식 1에서, R 1 및 R 2 는 서로 독립적으로 C 1 -C 6 의 알킬기 또는 아릴기이고, m은 1 내지 3의 정수임. In Formula 1, R 1 and R 2 are each independently an alkyl or aryl group of C 1 -C 6 , m is an integer of 1 to 3. 인계 화합물, 비스(4-터셔리-부틸페닐) 페닐포스포네이트, 비스(2,4,6-트리메틸페닐) 페닐포스포네이트, 방향족 비닐계 중합체, 스티렌계 수지, 폴리페닐렌 에테르, 난연, Flame retard Phosphorus compound, bis (4-tert-butylphenyl) phenylphosphonate, bis (2,4,6-trimethylphenyl) phenylphosphonate, aromatic vinyl polymer, styrene resin, polyphenylene ether, flame retardant, Flame retard

Manufacturing method for graphite sheet

본 발명의 흑연 시트의 제조 방법은, 폴리아믹산 용액에 흑연 발포제로서 인 또는 인 화합물을 특정 함량으로 첨가하여 인 또는 인 화합물 함유 폴리이미드 필름을 제조함으로써, 균일한 물성을 가지면서 열전도도가 우수한 가요성 흑연 시트를 두루마리 형태로 제조할 수 있다는 특징이 있다. The process for producing a graphite sheet of the present invention is a process for producing a graphite sheet, which comprises adding a phosphorus or phosphorus compound as a graphite foaming agent to a polyamic acid solution in a specific amount to produce a phosphorus or phosphorus compound-containing polyimide film, The graphite sheet can be produced in the form of a roll.

Method for preparing water-soluble sulphonated organophosphorous compounds

본 발명은 특히 2 상 촉매로 수행되는 유기 반응에 적당한 수용성의 술폰화된 유기인 화합물을 제조하는 방법에 관한 것이다. 본 발명은 수용성의 술폰화된 유기인 화합물이 촉매 리간드로서 사용되기 전 적어도 부분적으로 라디칼 및 술파이트 화합물을 제거하기 위해 처리되는 것을 특징으로 한다. 또한, 본 발명은 술파이트를 제거하기 위해, 처리되는 술폰화된 유기인 리간드를 포함하는 2 상 촉매계에 의해 촉매반응되는 유기 반응에 관한 것이다.

Method for purification of adefovir dipivoxil

본 발명은 화학식 1의 아데포비어 디피복실의 새로운 정제 방법에 관한 것으로, 본 발명에 따른 정제 방법은, 합성을 통하여 제조된 부산물이 포함된 불순한 상태의 아데포비어 디피복실을 유기용매로 추출하는 단계, 유기용매에 물을 첨가하고 산을 이용해 아데포비어 디피복실을 수층으로 추출하는 단계, 분리된 수층을 역상컬럼을 통해 정제하는 단계, 정제된 아데포비어 디피복실염 수용액에 염기를 첨가하여 아데포비어 디피복실로 전환시켜 유기용매로 추출하는 단계, 및 추출한 유기용매를 제거하여, 화학식 1로 표시되는 고순도의 무정형 아데포비어 디피복실을 수득하는 단계를 포함한다. [화학식 1] 역상컬럼, 항바이러스제, 정제방법, 아데포비어 디피복실

Stabilized composition, method of stabilization of organic phosphite of phosphonite, and organic phosphite or phosphonite stabilized against hydrolysis

FIELD: chemical industry. SUBSTANCE: described are stabilized composition comprising, calculated for total weight, (a) from 25 to 89 wt % of organic phosphite or phosphonite, (b) from 0.01 to wt % of organic amine and (c) from 0.01 to 25 wt % of acid binding metal salt, and also method of stabilization of organic phosphites or phosphonites against hydrolysis by addition of organic amine and acid binding metal salt. Said compositions have outstanding stability when stored under conditions of higher air humidity. Claimed composition and product stabilized by claimed method are useful as stabilizers of organic materials against destructive effect of heat, oxygen and/or light. EFFECT: improved properties of the stabilized composition. 12 cl, 4 ex, 4 tbl 6бГУОбОфтГсС ПЧ Го (19) 13) ВИ "” 2140 419 ' (51) МПК Сл С 07Е 9/145, 9/48, 9/6574 РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 95104928/04, 04.04.1995 (71) Заявитель: Циба Спешиалти Кемикалс Холдинг, Инк. (СН) (24) Дата начала действия патента: 04.04.1995 (72) Изобретатель: Хельмут Линхарт (СН), Удо Квотшалла (0Е), Джейн-Рох Рауквет (ВЕ), Рональд Залатэ (СН), Юрг Цингг (СН) (30) Приоритет: 05.04.1994 СН 985/94-6 (46) Дата публикации: 21.10.1999 (73) Патентообладатель: (56) Ссылки: ЕР 0167969 А2, 15.01.86. ЕР 0576833 Циба Спешиалти Кемикалс Холдинг, Инк. (СН) А2, 05.01.94. 4$ З787ЪЗ3Т А, 22.01.74. $0 155789 А, 15.08.80. (98) Адрес для переписки: 113054, Москва, Большой Строченовский пер.22/25, "Бейкер и Макензи", Ариевичу Е.А. (54) СТАБИЛИЗИРОВАННАЯ КОМПОЗИЦИЯ, СПОСОБ СТАБИЛИЗАЦИИ ОРГАНИЧЕСКОГО ФОСФИТА ИЛИ ФОСФОНИТА И СТАБИЛИЗИРОВАННЫЙ ПРОТИВ ГИДРОЛИЗА ОРГАНИЧЕСКИИ ФОСФИТ ИЛИ ФОСФОНИТ (57) Реферат: Заявляется стабилизированная выдающейся = устойчивостью против гидролиза и показывают хорошую композиция, содержащая в расчете на общую массу а) от 25 до 99 мас.% органического фосфита или фосфонита, Б) от 0,01 до 50 мас.% органического амина и с) ...

Method for removing volatile components from a high viscosity liquid by using rotation pack bed

A high viscosity liquid is fed into a rotation pack bed at a position with a distance far enough from a rotation axis, creating a centrifugal force exerted on the high viscosity liquid overwhelming a drag thereof, so that it can flow radially through the rotation pack bed. A high pressure gas is introduced into the rotation pack bed peripherally and/or a suction force source is connected to a position near the rotation axis, so that a volatile component contained in the high viscosity fluid is entrained in the gas counter currently flowing through the rotation pack bed and withdrawn from the position near the rotation axis, or the volatile component exits from the position near the rotation axis in gas phase, and thus the volatile component is removed from the high viscosity liquid. A second fluid can also be fed into the rotation pack bed to react with the high viscosity liquid, so that a reaction product is formed, and a volatile side product is removed at the same time.

Optically active catalyst for asymmetrical hydrogenation of substituted acrylic acids

Method of preparing optical isomers of beta-substituted of alpha-acylamidopropionic acids

Method for the preparation of 3,3-bis-[bis-(2-methoxyphenyl)phosphanylmethyl]-1,5-dioxy -spiro [5,5] undecane and their derivatives

The present invention relates to a process for the preparation of 3,3-bis- [bis- (2-methoxyphenyl) phosphanylmethyl] -1,5-dioxy-spiro [5,5 ] Undecane and derivatives thereof, and relates to a safe and efficient production method in mass production.

How to stabilize phosphite ligands

본 발명은 Ⅷ족 전이금속 촉매 및 포스파이트 리간드를 함유하는 균질한 반응 혼합물에 포스파이트 리간드의 분해를 감소시키기에 충분한 소량의 에폭사이드[여기서, 당해 에폭사이드의 양은, 반응 혼합물의 총 중량을 기준으로 하여, 0.001 내지 5중량% 이다]를 가함을 포함하며, 163족 전이금속 촉매 및 포스파이트 리간드를 함유하는 균질한 반응 혼합물 중에서의 분해에 대하여 포스파이트 리간드를 안정화하는 방법.

Method of obtaining optically active diphosphines

Method of preparing aluminium ethylphosphite

Prepn. of aluminium ethylphosphite comprises reaction of an excess of a ternary equilibrium mixt. of 23-93% of diethylphosphite, 59-7% of monoethylphosphite and 18-0.1% of phosphorous acid on opt hydrated alumina at 20-100 degrees C under reduced pressure, the water produced in the reaction being eliminated simultaneously. Process gives high yields and good reproducibility of product, used as a plant fungicide. Process is suitable for industrial scale. In a typical reaction, a mean yield of 96% was obtd. by reaction of a mixt. of 43% diethylphosphite, 49% of monoethylphosphite and 8% of phosphorous acid with alumina type H10 at 25-60 degrees C to give 95.2% aluminium ethylphosphite.

Composition containing chloromethyl phosphate derivative with improved stability and process for producing the same

本发明涉及对制备水溶性前药有用的磷酸氯甲酯衍生物的制备方法，并提供工艺性、操作性及节省能源性方面优良的制备方法等。本发明提供一种含有下述式(I)表示的化合物和叔胺的组合物的制备方法，该方法包括向下述式(I)表示的化合物中添加叔胺的步骤。(式中，R1及R2相同或不同，表示C1-C6烷基、C2-C6链烯基或可以具有取代基的C6-C14芳基C1-C6烷基，R1和R2可以结合在一起形成环)。

Process for the preparation of hydrolysis-stable trivalent phosphorus compounds and their use as stabilizers for thermoplastics and thermoplastics composition containing hydrolysis-stable trivalent phosphorus compounds

PURPOSE: Provided are a preparation process of hydrolysis-stable trivalent organophosphorus compounds which are to be used as stabilizers for thermoplastics. Also, provided is a thermoplastics composition containing the hydrolysis-stable trivalent organophosphorus compounds. CONSTITUTION: A process for the preparation of hydrolysis-stable trivalent phosphorous compounds of the formula(I) of P(OR¬1)3, the formula(II) or the formula(III) of R¬3 -£P(OR¬2)2 |n, comprises the steps of: treating the compounds of the formula (I, II, or III) in a solvent or a suspending agent with 0.005 to 5% by weight of an oxide, a hydroxide, a carbonate, a bicarbonate, or a carboxylate of a metal of groups 1a, 2a, 2d, or 7b of the periodic table of the elements, stirring the solution or suspension, and isolating the phosphorous compound. In the formulae, n is 1 or 2 R¬1 is a phenyl radical, which can be substituted by one or more linear or branched C1 -C8 -alkyl radicals or by C5 -C8 -cycloalkyl, C6 -C10 -aryl or C7 -C10 -aralkyl radicals, R¬2 is a linear or branched C8 -C20 -alkyl radical or a phenyl radical, which can be substituted by one or more linear or branched C1 -C8 -alkyl radicals or by C5 -C8 -cycloalkyl, C6 -C10 -aryl or C7 -C10 aralkyl radicals, R¬3, if n=1, is a phenyl or benzyl radical, which can carry I to 3 substituents, an .alpha.-methylbenzyl, .alpha.,.alpha.-dimethylbenzyl, or naphthyl radical or a naphthyl radical which carries 1 to 5 substituents, in which the substituents are identical or different and are a linear or branched C1 -C8 -alkyl radical, a C1 -C8 -alkoxy radical, a C1 -C12 -alkylthio radical, a C1 -C8 -dialkylamino radical, a C6-C10 -aryloxy radical or halogen having an atomic number of 9 to 35 and R¬3, if n=2, is a phenylene radical, a biphenylene radical, a naphthylene radical or a diphenylene oxide radical, which are unsubstituted or carry 1 to 4 linear or branched C1 -C8 -alkyl radicals.

Ligand purification methods

FIELD: chemistry. SUBSTANCE: invention relates to a method for purifying organopolyphosphite ligand, including: (a) obtaining solid organopolyphosphite ligand, which was recrystallized or ground at least once, wherein solid organopolyphosphite ligand contains more than one weight percent of impurity of oxidized phosphite and wherein organopolyphosphite ligand does not essentially contain a solvent; (b) suspending solid organopolyphosphite ligand in C 2 or higher alcohol at a temperature of at least 60°C for at least 20 minutes in order to reduce the amount of impurity of oxidized phosphite in a solid phase; and (c) removing liquid containing the dissolved impurity of oxidized phosphite from the suspension, wherein the residual content of impurity of oxidized phosphite in organopolyphosphite ligand after the stage (c) is 1% by wt. or less, and wherein the term “does not essentially contain a solvent” includes organopolyphosphite that does not contain a solvent other than the one found to be included in a solvate form, that is, the crystallization solvent. EFFECT: purification of ligand. 10 cl, 6 ex, 2 tbl РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 770 753 C2 (51) МПК C07F 9/6574 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07F 9/6574 (2022.02) (21)(22) Заявка: 2020100544, 12.06.2018 (24) Дата начала отсчета срока действия патента: Дата регистрации: (73) Патентообладатель(и): ДАУ ТЕКНОЛОДЖИ ИНВЕСТМЕНТС ЛЛК (US) 21.04.2022 19.06.2017 US 62/521,643 (43) Дата публикации заявки: 13.07.2021 Бюл. № 20 (45) Опубликовано: 21.04.2022 Бюл. № 12 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 13.01.2020 (56) Список документов, цитированных в отчете о поиске: WO 2013066712 A1, 10.05.2013. US 2013225849 A1, 29.08.2013. EA 001483 B1, 23.04.2001. Интернет-источник https://www.booksite.ru/fulltext/1/001/008/105/ 321.htm, опубликованный в Wayback Internet Archive Machine 21.05.2007. 2 7 7 0 7 5 3 Приоритет(ы ...

Treatment of m-(phosphomethyl)glycine

FIELD: medicine. SUBSTANCE: material, containing glyphosate, is diluted or suspended in water in the presence of the base with production of composition, including glyphosate salt in water solution of the base then without preliminary concentration and filtration the produced composition is added into acid and precipitated neutralised glyphosate is separated. EFFECT: development of the method of glyphosate treatment. 10 cl, 1 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 369 611 (13) C2 (51) МПК C07F 9/38 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21), (22) Заявка: 2006145439/04, 20.05.2005 (24) Дата начала отсчета срока действия патента: 20.05.2005 (73) Патентообладатель(и): ДАУ АГРОСАЙЕНСИЗ ЛЛС (US) (43) Дата публикации заявки: 27.06.2008 2 3 6 9 6 1 1 (45) Опубликовано: 10.10.2009 Бюл. № 28 (56) Список документов, цитированных в отчете о поиске: SU 1282820 A3, 07.01.1987. СА 2451507 А1, 03.01.2003. US 4237065 А, 02.12.1980. US 3799758 А, 26.03.1974. EP 0806428 A, 12.11.1997. ЕР 0413672 А, 20.02.1991. 2 3 6 9 6 1 1 R U (86) Заявка PCT: US 2005/017989 (20.05.2005) C 2 C 2 (85) Дата перевода заявки PCT на национальную фазу: 21.12.2006 (87) Публикация PCT: WO 2005/113567 (01.12.2005) Адрес для переписки: 129090, Москва, ул. Б.Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", пат.пов. Е.Е.Назиной (54) ОЧИСТКА N-(ФОСФОНОМЕТИЛ)ГЛИЦИНА (57) Реферат: Настоящее изобретение относится к способу очистки N-(фосфонометил)глицина (глифосата). Предложенный способ состоит в том, что материал, содержащий глифосат, растворяют или суспендируют в воде в присутствии основания с получением композиции, включающей соль глифосата в водном растворе основания, затем без предварительного концентрирования и фильтрации полученную композицию приводят в контакт с кислотой и выделяют осажденный нейтрализованный глифосат. Технический результат - разработка способа очистки глифосата. 1 н. и 9 з.п. ф-лы. ...

Fluid treatment process

Non-aqueous functional fluids are treated to avoid degradation or to recondition degraded fluids by a process which comprises contacting the fluid with an anionic ion-exchange resin and subsequently removing water by vacuum dehydration. The fluids can be restored and maintained at a water content of less than 0.1 % w/w and an acid number of less than 0.2 mgKOH/gm. The fluid is preferably a triaryl phosphate based fluid. Treated fluids may exibit improved properties especially increased resistivity.

Fluid treatment process

Non-aqueous functional fluids are treated to avoid degradation or to recondition degraded fluids by a process which comprises contacting the fluid with an anionic ion-exchange resin and subsequently removing water by vacuum dehydration. The fluids can be restored and maintained at a water content of less than 0.1 % w/w and an acid number of less than 0.2 mgKOH/gm. The fluid is preferably a triaryl phosphate based fluid. Treated fluids may exibit improved properties especially increased resistivity.

Fluid treatment method

Fluid treatment process

METHOD FOR TREATING LIQUIDS

FLUID TREATMENT PROCEDURE.

FLUIDOS FUNCIONALES NO ACUOSOS SON TRATADOS PARA EVITAR LA DEGRADACION O REACONDICIONAR FLUIDOS DEGRADADOS MEDIANTE UN PROCESO QUE COMPRENDE EL PONER EN CONTACTO EL FLUIDO CON UNA RESINA DE INTERCAMBIO DE IONES ANIONICA Y POSTERIORMENTE ELIMINAR AGUA MEDIANTE DESHIDRATACION AL VACIO. LOS FLUIDOS PUEDEN SER RESTAURADOS Y MANTENIDOS EN UN CONTENIDO DE AGUA DE MENOS DEL 0,1% P/A Y UN NUMERO ACIDO DE MENOS DE 0,2 MGKOH/GM. EL FLUIDO ES PREFERIBLEMENTE UN FLUIDO BASADO EN FOSFATO DE TRIARILO. LOS FLUIDOS TRATADOS PUEDEN MOSTRAR PROPIEDADES MEJORADAS ESPECIALMENTE RESISTENCIA MEJORADA. NON-WATERFUL FUNCTIONAL FLUIDS ARE TREATED TO AVOID DEGRADATION OR RECONDITIONED DEGRADED FLUIDS THROUGH A PROCESS THAT UNDERSTANDS THE FLUID CONTACT WITH AN ANIONIC ION EXCHANGE RESIN AND POSSIBLY REMOVE WATER BY DISPOSING. THE FLUIDS CAN BE RESTORED AND MAINTAINED IN A WATER CONTENT OF LESS THAN 0.1% P / A AND AN ACID NUMBER OF LESS THAN 0.2 MGKOH / GM. THE FLUID IS PREFERIBLY A FLUID BASED ON TRIARILE PHOSPHATE. TREATED FLUIDS CAN SHOW IMPROVED PROPERTIES SPECIALLY IMPROVED RESISTANCE.

Reclamation of organophosphate fluids

Acidity of used organophosphate containing functional fluids is reduced by contact with activated alumina. The activated alumina is regenerated for reuse by a sequential leaching/heating process.

Method of purifying neutral organophosphorus extractants

A method for removing acidic contaminants from neutral mono and bifunctional organophosphorous extractants by contacting the extractant with a macroporous cation exchange resin in the H + state followed by contact with a macroporous anion exchange resin in the OH - state, whereupon the resins take up the acidic contaminants from the extractant, purifying the extractant and improving its extraction capability.

METHOD FOR TREATING LIQUIDS

Fluid treatment process

Reclamation of organophosphate fluids

Abstract of the Disclosure Acidity of used organophosphate containing functional fluids is reduced by contact with activated alumina. The activated alumina is regenerated for re-use by a sequential leaching/heating process.

Method of purification of ethylenediaminotetra(methylenephosphonic acid) or 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosph- onic acid)

Использование: в производстве замещенных метиленфосфоновой кислоты. Сущ- ность изобретени : способ предусматривает очистку соответствующей сырой этилендиа- минотетра(метиленфосфоновой кислоты) (Н0)2 P(0)ЈNCH2CH2N P(OXOH)2b или 1,4,7,10 -тетраазациклододекан-1,4,7,10-тетра(ме- тиленфосфоновой кислоты) путем растворени  в водном растворе гидроокиси аммони . Затем обрабатывают полученный раствор ЗМ HCI, нагрееэют реакционную смесь до 35-105°С в течение времени, достаточного дл  того, чтобы началось осаждение аминометиленфосфоновой кислоты, отфильтровывают ее кристаллы и промывают их, 3 з.п.ф-лы.

METHODS FOR PURIFICATION OF LIGANDS

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2020 100 544 A (51) МПК C07F 9/6574 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2020100544, 12.06.2018 (71) Заявитель(и): ДАУ ТЕКНОЛОДЖИ ИНВЕСТМЕНТС ЛЛК (US) Приоритет(ы): (30) Конвенционный приоритет: 19.06.2017 US 62/521,643 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 13.01.2020 R U (43) Дата публикации заявки: 13.07.2021 Бюл. № 20 (72) Автор(ы): БИГИ, Маринус А. (US), БРАММЕР, Майкл А. (US), МИЛЛЕР, Гленн А. (US) (86) Заявка PCT: (87) Публикация заявки PCT: WO 2018/236623 (27.12.2018) A Адрес для переписки: 105082, Москва, Спартаковский пер., д. 2, стр. 1, секция 1, этаж 3, ЕВРОМАРКПАТ (54) СПОСОБЫ ОЧИСТКИ ЛИГАНДОВ R U 1. Способ, включающий: (а) получение твердого органополифосфитного соединения, которое было перекристаллизовано или растерто по меньшей мере один раз, причем твердое органополифосфитное соединение содержит более одного массового процента окисленной фосфитной примеси и причем органополифосфитное соединение по существу не содержит растворителя; (b) суспендирование твердого органополифосфитного соединения в С2 или высшем спирте при температуре по меньшей мере 60°С в течение по меньшей мере 20 минут, чтобы уменьшить количество примеси окисленного фосфита в твердой фазе; и (c) удаление жидкости, содержащей растворенную примесь окисленного фосфита, из суспензии, причем остаточное содержание примеси окисленного фосфита в органополифосфитном соединении после стадии (с) составляет 1 % мас. или менее. 2. Способ по п. 1, отличающийся тем, что органополифосфит представляет собой органобисфосфит. 3. Способ по п. 1 или 2, отличающийся тем, что растворенную примесь окисленного фосфита удаляют фильтрацией или центрифугированием. 4. Способ по любому из предыдущих пунктов, дополнительно включающий повторение стадий (b) и (c) один или несколько раз. 5. Способ по любому из предыдущих пунктов, отличающийся тем, что твердое Стр.: 1 A 2 0 2 0 1 0 0 5 ...

Process for preparing acylphosphanes and derivatives thereof

本发明涉及一种制备式I的(双)酰基磷烷的方法，其中n及m相互独立地是1或2；R 1 ，如果n＝1，是例如未取代的或取代的C 1 -C 18 烷基或C 2 -C 18 烯基，或苯基，R 1 ，如果n＝2，是例如以上所定义的单价基团的二价基团；R 2 是例如C 1 -C 18 烷基、C 3 -C 12 环烷基、C 2 -C 18 烯基、2，4，6-三甲苯基、苯基、萘基；R 3 是在R 1 下所定义的基团之一；所述方法包括以下步骤：a)任选地在存在催化剂或活化剂的情况下在溶剂中将例如元素磷[P] ∞ 、P(Hal) 3 与还原性金属接触从而得到金属磷化物Me 3 P或Me’ 3 P 2 ，其中Me是碱金属以及Me′是碱土金属，或者从而得到金属多磷化物，b)任选地在存在催化剂或活化剂的情况下，任选地加入质子源从而得到金属二氢磷化物MePH 2 ；c)接着与m式III的酰基卤或m式IV的羧酸酯进行酰化反应或者在式I中m＝1的情况下与一式IV的羧酸酯进行反应且接着与一式III的酰基卤反应或反之亦可，其中R是醇的残基以及R 2 如上所定义；d)烷基化反应，接着与亲电试剂R 1 Hal或其他亲电试剂进行反应，从而得到式I的化合物。可以接着进行氧化步骤从而得到单-及双酰基磷烷氧化物或者单-及双酰基磷烷硫化物，其可用作光引发剂。

Purification of l-ascorbic acid 2-phosphate

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Process for purifying aminomethylenephosphonic acids

Manufacture of monoethyllaluminum phosphite

(2-alkyl-2-halo-1-(thio)ether) vinyl phosphonates(phosphates) - as pa

vinyl phosphonates (phosphates) - as parasiticides. Cpds. (I):- (where R1 is 1-5C alkyl or alkoxy, opt. halo substd. phenyl, or 2-8C-dialkylamino; R2 is 1-5C alkyl; R is Me or Et, Z is Cl or Br; X is O or S and R3 is 1-5C alkyl opt. substd. by F, Cl, Br or 2-5C-alkoxy carbonyl, or Y is halogen, CN, NO2, 1-5C alkyl or alkoxy, 2-5C carbalkoxy, acetyl, 3-9C dialkylcarbonamides and n is 0-5) are prepd. by reacting R1-OR4 (where R is alkyl) with RC(Z)2-COX-R3. Thus (I, Z = Cl, R = Me, X = O, R3 = p-ClC6H4, R1 = R2 = Et) is prepd. from triethyl-phosphite and p-chlorophenyl alpha, alpha-dichloropropionate.

Aqueous hci titanium iii chloride catalises prep - chloroalkyl esters of 5 valent

The reaction is between a phosphonic or phosphoric acid chloride e.g. POCL3 and an alkylene oxide, e.g. ethylene, propylene, butyleneoxide, epichlorhydrin or polyfunctional such as diglycidyl ether. The preferred catalyst concentration is 0.001% wt. (based on P-reactant) of Ti as TiCl3 aqueous HCl.

Patent FR2259104B1

Process for deodorizing diethyl mercaptosuccinate o, o-dimethyl-dithiophosphate

A process for the preparation of glycerophospholipids

고도로 순수한 탈아실화된 글리세로포스포릴콜린, 글리세로포스포릴에탄올아민 및 글리세로포스포릴세린을 대응하는 아실화된 유도체로부터 제조하는 방법이 개시된다. A method for preparing highly pure deacylated glycerophosphorylcholine, glycerophosphorylethanolamine and glycerophosphorylserine from corresponding acylated derivatives is disclosed. 본 발명에 따른 방법은 알콜리시스에 의한 탈아실화 반응 및 분획화가 염기성 이온교환수지를 함유하는 반응기 내에서 하나의 단계로 수행되는 것을 특징으로 한다. The process according to the invention is characterized in that the deacylation reaction and fractionation by alcoholicsis is carried out in one step in a reactor containing a basic ion exchange resin.

Molybdenum compounds, in particular for lubricants

Metal inositol hexaphosphates - from inositol hexaphosphoric acid and organo metal cpd in anhydrous medium

Patent FR2148220B1

Plant fungicidal agents - contg organic phosphite esters or their salts

Fungicidal compsns. for combatting fungal diseases of plants contain, in addition to usual carriers and adjuvants, an effective amount of at least one cpd. of formula (I): (where R is opt. halogenated or nitrated 1-18C alkyl, opt. halogenated 1-8C alkenyl or alkynyl, is not >8C alkoxyalkyl or alkenyloxyalkyl, cyclohexyl, opt. substd. aryl or aralkyl, or a heterocyclic radical opt. linked to the O-atom via an aliphatic chain (pref. tetra-hydrofurfuryl); M is H, NH4, a substd. ammonium cation, or a metal cation; and n is an integer corresponding to the valence of M), e.g. sodium O-ethylphosphonate or Cu (II) O-isopropylphosphonate. (I) have excellent fungicidal properties, particularly against various mildews such as mildew of grapevines, tobacco or hops, and may be used for prophylactic or curative treatment.

STABILIZATION OF AQUEOUS SILICATES BY MEANS OF SILICONATES-SILYLALKYLPHOSPHONATES OF ALKALINE METALS

L'invention se rapporte aux silicones. Elle concerne une composition de matière constituée d'un siliconate-silylalkylphosphonate de métal alcalin ayant la formule générale unitaire : The invention relates to silicones. It relates to a composition of matter consisting of an alkali metal siliconate-silylalkylphosphonate having the general unit formula:

Patent FR2231681B1

Patent FR2259104A1

Phosphonium salts and processes for production of and uses for the same, and phosphines deriving the same and processes for production of the phosphines

Phosphonium salts represented by the general formula (see formula I) wherein R1 and R2 each represents a phenyl group which may be substituted by a lower alkyl group, R3 represents a phenylene group which may be substituted by a lower alkyl group, R7 and R8 each represents a hydrogen atom or a hydrocarbon group having 1 to 12 carbon atoms which may be substituted and R9 represents a hydrogen atom or a hydrocarbon group having 1 to 5 carbon atoms which may be substituted: processes for producing the same and uses for the same; phosphines providing the same, and processes for producing said phosphines.

A composition for detection of hydrogen bromide gas comprising dipyrrole derivatives and ammonium salts and a color conversion sensor comprising the same

The present invention relates to a process for the detection of hydrogen bromide gas, which comprises detecting the presence of a hydrogen bromide gas containing a dipyrrole derivative represented by the following formula (I) and an ammonium salt represented by the following formula (II) And a color conversion sensor for detecting hydrogen bromide gas containing the same. (I) [Formula II]

Process for the production of mixed condensation products

Improvements in the purification of secondary aryl phosphine oxides

Patent FR2070169A1

METAL COMPOUNDS OF PHOSPHORUS ACID MONOESTERS, ESPECIALLY FOR ANTI-CORROSION PREPARATIONS

Improvements to machines for instant coffee making in cups

Method for production of stabilizers with low chloride content

FIELD: organic chemistry, in particular agents for stabilization of organic materials. SUBSTANCE: invention relates to method for production of stabilizer mixture to prevent oxidative destruction, thermal destruction, or light-initiated destruction of organic materials. Claimed composition has low chloride content and comprises (mass %): a) tetrakis-biphenylene diphosphonite or isomers thereof 50-80; b) bis(2,4-di-tert-butylphenyl)-biphenylene monophosphonite or isomers thereof 5-25; c) tris(2,4-di-tert-butylphenyl) phosphite 5-25, wherein total content of a), b) and c) is not more than 100 mass %. Method is carried out by Friedel-Crafts reaction of biphenyl with phosphorus trichloride and aluminum trichloride; reaction of obtained mixture with 2,4-di-tert-butylphenol in presence of tertiary amine or aromatic amine and solvent, followed by separation of two formed layers. Method includes treatment of solvent layer with water, base and drying agent; separation of precipitate from solution containing stabilizer mixture; and solvent evaporation. EFFECT: improved treatment method for production of stabilizers with desired chloride content and product, which is not cloudy and does not initiate cloudiness in synthetic polymers. 10 cl, 10 ex ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (51) ÌÏÊ 7 (11) (13) 2 251 549 C2 C 07 F 9/145, 9/48, C 08 K 5/5393, 5/526 ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2000127430/04, 02.11.2000 (72) Àâòîð(û): ÒÎÀÍ Âüåí Âàí (CH), ÑÀËÀÇÅ Ðîíàëüä (CH) (24) Äàòà íà÷àëà äåéñòâè ïàòåíòà: 02.11.2000 (30) Ïðèîðèòåò: 02.11.1999 EP 99810997.9 (43) Äàòà ïóáëèêàöèè çà âêè: 27.10.2002 (45) Îïóáëèêîâàíî: 10.05.2005 Áþë. ¹ 13 2 2 5 1 5 4 9 R U (54) ÑÏÎÑÎÁ ÏÎËÓ×ÅÍÈß ÑÒÀÁÈËÈÇÀÒÎÐÎÂ Ñ ÍÈÇÊÈÌ ÑÎÄÅÐÆÀÍÈÅÌ ÕËÎÐÈÄÀ (57) Ðåôåðàò: ôîñôîðà è òðèõëîðèäîì àëþìèíè è ïîñðåäñòâîì Èçîáðåòåíèå êàñàåòñ ñïîñîáà ïîëó÷åíè ñìåñè ðåàêöèè ïîëó÷åííîé ñìåñè ïðîäóêòîâ ñ ñòàáèëèçàòîðîâ, êîòîðà ìîæåò áûòü ...

Process for stabilizing aqueous solutions of phosphoric esters

Lubricating and hydraulic oils

Method of obtaining optically-active amino acids

Process for the separation of the reaction products of phosphorus pentoxide and aliphatic alcohols containing 5 to 18 carbon atoms

New zinc salts that can be used as de-icers, in particular in gasoline compositions

PROCESS FOR THE PHOSPHITE TREATMENT OF PHOSPHOROUS ACID SALTS, COMPOSITIONS PRODUCED THEREBY, CONCENTRATE AND LUBRICANT CONTAINING THE SAME

LA PRESENTE INVENTION CONCERNE UN PROCEDE POUR AMELIORER LES PROPRIETES DE SELS D'ACIDES DU PHOSPHORE DE FORMULE (RO)PSSH, DANS LAQUELLE CHAQUE H EST INDEPENDAMMENT UN RADICAL A BASE D'HYDROCARBURE. CE PROCEDE EST CARACTERISE EN CE QU'ON MET EN CONTACT CES SELS OU LEURS PROGENITEURS ACIDES DU PHOSPHORE AVEC AU MOINS UN PHOSPHITE DE LA FORMULE (RO)P, DANS LAQUELLE CHAQUE R EST INDEPENDAMMENT DE L'HYDROGENE OU UN RADICAL A BASE D'HYDROCARBURE ET AU MAXIMUM UN R EST DE L'HYDROGENE, A UNE TEMPERATURE COMPRISE ENTRE 50C ENVIRON ET 200C ENVIRON. LES COMPOSITIONS AINSI PREPAREES SONT UTILES COMME ADDITIFS POUR LUBRIFIANTS OU FLUIDES FONCTIONNELS.

Process for the purification of triaryl phosphates

Patent FR2253026A1

Patent FR2402663B2

Patent FR2254276A1

Process for the separation of mono- and di-alkyl phosphates

Patent FR2306211B1

Precursor compositions and methods

Compositions including an amido-group-containing vapor deposition precursor and a stabilizing additive are provided. Such compositions have improved thermal stability and increased volatility as compared to the amido-group-containing vapor deposition precursor itself. These compositions are useful in the deposition of thin films, such as by atomic layer deposition.

Method of stabilizing organic phosphites and phosphonites and mixtures stabilized in such a manner

PREPARATION OF SILYLALKYL ESTERS OF PHOSPHORUS.

Patent FR2230654B1

Patent FR2253026B1

METHOD FOR PREPARING A FUNGICIDE PREPARATION AND PREPARED PREPARATION THEREOF, AND METHOD FOR COMBATING FUNGI IN CROPS WITH A PREPARED PREPARATION

Process for the production of phosphor organic compounds

본 발명은 프리델-크래프츠(Friedel-Crafts) 반응 생성물을 알콜 또는 페놀과 반응시키는 단계 및 생성된 부산물을 분리하여 제거하는 단계를 포함하는, 포스포나이트(phosphonite) 또는 포스피나이트(phosphinite)의 제조 방법에 관한 것이다. 본 발명의 방법은 양성자성 화합물, 또는 금속의 산화물, 수산화물, 탄산(수소)염 또는 인산(수소)염, 또는 질소 함유 화합물(제 1 항에 정의된 바와 같음), 또는 이들 화합물 1종 이상의 화합물들로 이루어진 임의의 배합물로 후처리를 수행함을 특징으로 한다. 본 발명에 의해, 적은 할라이드 함량 및 적은 알루미늄 함량을 가지며, 개선된 투명 용해도 및 중합체성 물질에 대한 안정화제로서의 개선된 작용을 가짐을 특징으로 하는 생성물을 수득할 수 있다. The present invention comprises the steps of reacting a Friedel-Crafts reaction product with an alcohol or phenol and separating and removing the resulting by-products of phosphonite or phosphinite. It relates to a manufacturing method. The process of the present invention comprises a protic compound, or an oxide, hydroxide, carbonate (hydrogen) salt or phosphoric acid (hydrogen) salt of a metal, or a nitrogen containing compound (as defined in claim 1), or one or more of these compounds And post-treatment with any combination of these components. By the present invention, it is possible to obtain products characterized by having a low halide content and a low aluminum content and having an improved clear solubility and an improved action as a stabilizer for polymeric materials.

Composition comprising stabilized phosphorus compounds

A composition comprising at least a phosphorus compound and a stabilizer compound having one of the formulae I to IV can be used for increasing the shelf life or reducing metal corrosion.