03-10-2013 дата публикации
Номер: US20130261077A1
Автор:
Bennani Youssef Laafiret,
Cadilhac Caroline,
Das Sanjoy Kumar,
Dietrich Evelyne,
Gallant Michel,
Liu Bingcan,
Pereira Oswy Z.,
Ramtohul Yeeman K.,
Reddy T. Jagadeeswar,
Vaillancourt Louis,
Vallee Frederic,
Yannopoulos Constantin
The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: 2. The compound of claim 1 , wherein{'sub': 8', '8', '2', 'm', '8', '8', '8', '2', '8', '2', '8', '8', '2', '8', '1', '6', '1', '6', '1', '6', '1', '6', 'n', '1-6', '8', '1-6', '8', '1-6', '1', '6, 'sup': '10', 'Y is absent, or is —NR, —O—, —S—, —C(O)—, —C(R)(OH)—, —C(O)N(R)(CH)—, —N(R)C(O)O—, —OC(O)NR—, —NRSO—, —NR—C(O)—, —SO—, —NRC(O)NR—, —S(O)—, —SONR, —(C-C)alkyl-, —(C-C)alkenyl-, —(C-C)alkynyl-, —(O—(C-Calkyl))-, —O—(Calkyl)NRC(O)—, —O—(Calkyl)C(O)NR, —O—(Calkyl)-C(O)—, or —((C-C)alkyl)-O—;'}{'sub': 3A', '3B', '10', '3', '10', '2', '2', 'n', '4', '2', 'n', '4', '2', 'n', '4', '2', '4', '4', '2', '4', '4', '2', '4', '4', '2', '4', '4', '2', '4', '4', '4', '2', '4', '4', '4', '2', '4', '2, 'each Rand Ris independently —OH, —CN, halogen, —C(R), —C(R)OH, —(CH)OR, —(CH)C(O)OR, —(CH)N(R), —C(O)OR, —C(O)N(R), —N(R)C(O)(R), —OC(O)NHR, —NHC(O)OR, —NHSOR, —NH—C(O)R, —SO—R, —NHC(O)NHR, —S(O)R, —SONHR, —SR, —P(O)(OR), or —P(O)(R); and'}{'sub': 4A', '10', '3', '10', '2', '2', 'n', '4', '2', 'n', '4', '2', 'n', '4', '2', '4', '4', '2', '4', '4', '2', '4', '4', '2', '4', '4', '2', '4', '4', '4', '2', '4', '4', '4', '2', '4', '2, 'Ris —OH, —CN, halogen, —C(R), —C(R)OH, —(CH)OR, —(CH)C(O)OR, —(CH)N(R), —C(O)OR, —C(O)N(R), —N(R)C(O)(R), —OC(O)NHR, —NHC(O)OR, —NHSOR, —NH—C(O)R, —SO—R, —NHC(O)NHR, —S(O)R, —SONHR, —SR, —P(O)(OR), —P(O)(R); and'}{'sup': '7', 'Ris H or mannosyl.'}3. The compound of claim 1 , wherein:X is —OH;{'sub': 8', '2', '1', '6', '1', '6', '1', '6', '1', '6', 'n', '1-6', '8', '1-6', '8', '1-6', '1', '6, 'sup': '10', 'Y is absent, or is —NR, —O—, —S—, —C(O)—, —C(R)(OH)—, —SO—, —S(O)—, —(C-C)alkyl, —(C-C)alkenyl, —(C-C)alkynyl, —(O—(C-Calkyl))-, —O(Calkyl)N—RC(O)—, —O—(Calkyl)-C(O)NR, —O—(Calkyl)C(O)—, or —((C-C)alkyl)-O—;'}{'sub': 2', '6-10', '6-10', '1', '6', '2', '6-10', '6-10', '1', '6, 'Ris Caryl, (Caryl)-(C-Calkyl)-, or 5- ...
Подробнее
