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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 305774. Отображено 100.

05-01-2012 дата публикации

Tuberculosis antigens, immunogenic compositions, diagnostics and methods related to the same

Номер: US20120003256A1

Автор: Alan Greener, Dongxin K. Xu, Huiling Han

Принадлежит: Gene Therapy Systems

Provided herein are Mtb polynucleotides, recombinant Mtb peptides and polypeptides, immunogenic Mtb antigens, and Mtb antibodies. Immunogenic compositions are also provided that may be useful as recombinant, subunit and DNA vaccines. In addition the invention provides kits comprising Mtb polynucleotides, Mtb polypeptides, Mtb antibodies, and combinations thereof.

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Номер записи: 1

05-01-2012 дата публикации

Recombinant avian infectious coryza vaccine and process for preparing same

Номер: US20120003257A1

Автор: Hiroshi Mizokami, Masashi Sakaguchi, Ryuichi Sakamoto, Susumu Baba

Принадлежит: Chemo Sero Therapeutic Research Institute Kaketsuken

A recombinant avian infectious coryza vaccine and a process for preparing the same are provided. A process for preparing a recombinant avian infectious coryza vaccine which comprises step of constructing E. coli that may produce as an inclusion body a fusion peptide consisting of peptides derived from outer-membrane protein of Avibacterium paragarinarum serotype A and serotype C, step of culturing said E. coli and colleting and purifying inclusion body from culture, and step of preparing a preparation comprising said purified inclusion body, and an avian infectious coryza vaccine comprising as an active ingredient the fusion peptide. A linker sequence may be inserted between the respective peptides comprising the fusion peptide. For the peptide derived from the serotypes A and C, an amino acid sequence region of Region 2 or its vicinity responsible for protection from infection may be used.

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Номер записи: 2

05-01-2012 дата публикации

Immunogenic compositions for inducing an immune response to hiv

Номер: US20120003265A1

Автор: John H. Eldridge, Maninder K. Sidhu, Michael Egan, Zimra Israel

Принадлежит: WYETH LLC

The invention relates to immunogenic compositions for inducing an immune response to HIV comprising combinations of two, three, or four plasmids, where each plasmid is expressing a defined antigen, which may be a single antigen or a fusion of two or three antigens.

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Номер записи: 3

05-01-2012 дата публикации

Compositions Produced Using Enteric Pathogens and Methods of Use

Номер: US20120003269A1

Автор: Darren E. Straub, Daryll A. Emery, Laura Wonderling

Принадлежит: Epitopix LLC

The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella . Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.

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Номер записи: 4

05-01-2012 дата публикации

Novel fructosyl peptide oxidase

Номер: US20120003678A1

Автор: Kazuo Aisaka, Keiko Suzuki, Toshiko Aisaka

Принадлежит: Kyowa Medex Co Ltd

A protein described in any one of [1] to [4] below is provided according to the present invention: [1] a protein comprising the amino acid sequence represented by SEQ ID NO: 1; [2] a protein comprising an amino acid sequence with one or more amino acid deletions, substitutions, or additions in the amino acid sequence represented by SEQ ID NO: 1, and having fructosyl peptide oxidase activity; [3] a protein comprising an amino acid sequence having 80% or higher homology to the amino acid sequence represented by SEQ ID NO: 1, and having fructosyl peptide oxidase activity; and [4] a protein having fructosyl peptide oxidase activity, which is produced by an expression plasmid harbored by the Escherichia coli XL1-Blue MRF' strain deposited under Accession No. FERM BP-11026.

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Номер записи: 5

10-12-2009 дата публикации

УСТАНОВКА ДЛЯ ПОЛУЧЕНИЯ МАКРОПОРИСТЫХ ПОЛИМЕРНЫХ МАТЕРИАЛОВ

Номер: RU0000089522U1

Автор: Влах Евгения Георгиевна, Тенникова Татьяна Борисовна

Принадлежит: Учреждение Российской академии наук Институт высокомолекулярных соединений РАН

1. Установка для получения макропористых полимерных материалов монолитного типа для создания биоаффинных сорбентов, содержащая реакционную форму в виде колонки или пластины, рабочую герметизированную камеру, сушильную камеру, ванну с жидкой средой, контейнеры с компонентами, контейнер для хранения полученного материала, отличающаяся тем, что она дополнительно оснащена лазерным излучателем, емкостью с инертным газом, вакуум-насосом, сообщенными магистралями с полостью рабочей герметизированной камеры, оснащена также камерой с источником ультрафиолетового излучения и камерой для выдержки полученного материала, соединенной с источником инертного газа, прибором контроля параметров полученного полимерного материла. 2. Установка по п.1, отличающаяся тем, что контейнеры заполнены исходными компонентами соответственно: контейнер с глицидилметакрилатом, контейнер с N-гидроксифталимидным эфиром акриловой кислоты, контейнер с этиленгликольдиметакрилатом, контейнер с порогенными растворителями и инициатором. 3. Установка по п.1, отличающаяся тем, что в качестве прибора контроля используют сканирующий электронный микроскоп. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 89 522 (13) U1 (51) МПК C08J 5/00 (2006.01) C08F 220/00 (2006.01) C07K 17/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21), (22) Заявка: 2009126715/22, 13.07.2009 (24) Дата начала отсчета срока действия патента: 13.07.2009 (45) Опубликовано: 10.12.2009 (73) Патентообладатель(и): Учреждение Российской академии наук Институт высокомолекулярных соединений РАН (RU) U 1 8 9 5 2 2 R U Ñòðàíèöà: 1 ru CL U 1 Формула полезной модели 1. Установка для получения макропористых полимерных материалов монолитного типа для создания биоаффинных сорбентов, содержащая реакционную форму в виде колонки или пластины, рабочую герметизированную камеру, сушильную камеру, ванну с жидкой средой, контейнеры с компонентами, контейнер для хранения полученного ...

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Номер записи: 6

10-06-2013 дата публикации

УСТРОЙСТВО ДЛЯ ГИДРОЛИЗА ЖИВОТНОГО БЕЛКА В СОСТАВЕ ПИЩЕВЫХ ПРОДУКТОВ

Номер: RU0000128878U1

Автор: Вострикова Наталья Леонидовна, Иванкин Андрей Николаевич, Лисицын Андрей Борисович

Принадлежит: Государственное научное учреждение Всероссийский научно-исследовательский институт мясной промышленности им. В.М. Горбатова Российской академии сельскохозяйственных наук

Устройство для гидролиза белка, включающее реактор и патрубки для введения реагентов и отвода продуктов, отличающееся тем, что в качестве реактора используют стеклянный сосуд с боковым отводом для формирования атмосферы инертного газа и герметично завинчивающейся тефлоновой пробкой, позволяющей в нижнем положении герметизировать реактор, а в верхнем положении осуществлять загрузку сырья и вакуумировать внутреннюю часть реактора. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 128 878 U1 (51) МПК C07K 1/12 (2006.01) B01J 14/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ 2012154562/04, 17.12.2012 (24) Дата начала отсчета срока действия патента: 17.12.2012 (45) Опубликовано: 10.06.2013 Бюл. № 16 R U 1 2 8 8 7 8 Формула полезной модели Устройство для гидролиза белка, включающее реактор и патрубки для введения реагентов и отвода продуктов, отличающееся тем, что в качестве реактора используют стеклянный сосуд с боковым отводом для формирования атмосферы инертного газа и герметично завинчивающейся тефлоновой пробкой, позволяющей в нижнем положении герметизировать реактор, а в верхнем положении осуществлять загрузку сырья и вакуумировать внутреннюю часть реактора. Стр.: 1 U 1 U 1 (54) УСТРОЙСТВО ДЛЯ ГИДРОЛИЗА ЖИВОТНОГО БЕЛКА В СОСТАВЕ ПИЩЕВЫХ ПРОДУКТОВ 1 2 8 8 7 8 Адрес для переписки: 109316, Москва, ул. Талалихина, 26, ВНИИМП им. В.М. Горбатова Россельхозакадемии, Центр интеллектуальной собственности, М.В. Трифонову (73) Патентообладатель(и): Государственное научное учреждение Всероссийский научно-исследовательский институт мясной промышленности им. В.М. Горбатова Российской академии сельскохозяйственных наук (RU) R U Приоритет(ы): (22) Дата подачи заявки: 17.12.2012 (72) Автор(ы): Лисицын Андрей Борисович (RU), Иванкин Андрей Николаевич (RU), Вострикова Наталья Леонидовна (RU) RU 5 10 15 20 25 30 35 40 45 128 878 U1 Полезная модель относится к биотехнологии и может быть использовано в медицине, пищевой ...

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Номер записи: 7

05-01-2012 дата публикации

Hemostatic fibrous material

Номер: US20120004636A1

Автор: Denny Lo

Принадлежит: Denny Lo

This disclosure relates to devices for promoting the clotting of blood in human beings or animals, or hemostatic devices. These devices may comprise a fibrous material or materials comprising one or more fibers such as a gauze or a cloth. Some of the fibers in these materials or devices may comprise a macromolecular material and a hemostatic hemostatic additive material such as kaolin or another clay.

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Номер записи: 8

27-07-2016 дата публикации

УСТРОЙСТВО ДЛЯ ГИДРОЛИЗА ВОДНЫХ РАСТВОРОВ БЕЛКОВ

Номер: RU0000163602U1

Автор: Жилин Юрий Николаевич, Зенкин Александр Николаевич, Иванкин Андрей Николаевич, Олиференко Галина Львовна

Принадлежит: Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет леса"

Устройство для гидролиза водных растворов белков, включающее ферментер с теплообменным устройством и штуцерами ввода и вывода реагентов и продуктов, вентили для регулирования давления, пробоотборник, а также ультрафильтрационный блок, отличающееся тем, что ультрафильтрационный блок вмонтирован в нижнюю часть корпуса ферментера и снабжен штуцером вывода ретанта, при этом устройство снабжено поплавковым фильтром-заборником для подачи реакционной смеси в ультрафильтрационный блок, фильтр-заборник соединен с ультрафильтрационным блоком с помощью гибкого трубопровода. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 163 602 U1 (51) МПК C12M 1/40 (2006.01) C12N 11/02 (2006.01) C07K 1/12 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ 2016104545/04, 11.02.2016 (24) Дата начала отсчета срока действия патента: 11.02.2016 (45) Опубликовано: 27.07.2016 Бюл. № 21 R U 1 6 3 6 0 2 Формула полезной модели Устройство для гидролиза водных растворов белков, включающее ферментер с теплообменным устройством и штуцерами ввода и вывода реагентов и продуктов, вентили для регулирования давления, пробоотборник, а также ультрафильтрационный блок, отличающееся тем, что ультрафильтрационный блок вмонтирован в нижнюю часть корпуса ферментера и снабжен штуцером вывода ретанта, при этом устройство снабжено поплавковым фильтром-заборником для подачи реакционной смеси в ультрафильтрационный блок, фильтр-заборник соединен с ультрафильтрационным блоком с помощью гибкого трубопровода. Стр.: 1 U 1 U 1 (54) УСТРОЙСТВО ДЛЯ ГИДРОЛИЗА ВОДНЫХ РАСТВОРОВ БЕЛКОВ 1 6 3 6 0 2 Адрес для переписки: 141005, Московская обл., г. Мытищи-5, ул. 1-я Институтская, 1, МГУЛ, патентный отдел (73) Патентообладатель(и): Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет леса" (RU) R U Приоритет(ы): (22) Дата подачи заявки: 11.02.2016 (72) Автор(ы): Жилин Юрий Николаевич (RU ...

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Номер записи: 9

10-01-2017 дата публикации

УСТРОЙСТВО ДЛЯ ГИДРОЛИЗА ВОДНЫХ РАСТВОРОВ БЕЛКОВ

Номер: RU0000167833U1

Автор: Гаврюшкин Александр Алексеевич, Жилин Юрий Николаевич, Иванкин Андрей Николаевич, Олиференко Галина Львовна

Принадлежит: Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет леса"

Использование: биотехнология, в пищевой промышленности, медицине и сельском хозяйстве. Сущность решения: в обогреваемый водой ферментер 1 через штуцеры 3 и 4 подают соответственно суспензию иммобилизированного фермента и водный раствор белка. Отделение полученного гидролизата белка от общей реакционной массы происходит на ультрафильтрационной мембране 8, расположенной в днище ферментера, через штуцер 6. Подача сжатого воздуха в ферментер 1 осуществляется снизу через вращающуюся камеру барботера 12, плотно прилегающую верхним открытым краем к дренажной пластине 9. В крышке ферментера 1 установлен штуцер 7 с вентилем для регулирования давления в ферментере 1. 1 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 167 833 U1 (51) МПК C12M 1/40 (2006.01) C12N 11/02 (2006.01) C12P 21/06 (2006.01) C07K 1/12 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21)(22) Заявка: 2016126447, 01.07.2016 (24) Дата начала отсчета срока действия патента: 01.07.2016 Дата регистрации: (73) Патентообладатель(и): Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет леса" (RU) Приоритет(ы): (22) Дата подачи заявки: 01.07.2016 (45) Опубликовано: 10.01.2017 Бюл. № 1 20150159189 A1, 11.06.2015. R U 1 6 7 8 3 3 (54) УСТРОЙСТВО ДЛЯ ГИДРОЛИЗА ВОДНЫХ РАСТВОРОВ БЕЛКОВ (57) Реферат: Использование: биотехнология, в пищевой расположенной в днище ферментера, через промышленности, медицине и сельском хозяйстве. штуцер 6. Подача сжатого воздуха в ферментер Сущность решения: в обогреваемый водой 1 осуществляется снизу через вращающуюся ферментер 1 через штуцеры 3 и 4 подают камеру барботера 12, плотно прилегающую соответственно суспензию иммобилизированного верхним открытым краем к дренажной пластине фермента и водный раствор белка. Отделение 9. В крышке ферментера 1 установлен штуцер 7 полученного гидролизата белка от общей с вентилем для регулирования давления в реакционной массы ...

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Номер записи: 10

21-07-2020 дата публикации

УСТРОЙСТВО ДЛЯ ПОЛУЧЕНИЯ КОЛЛАГЕНА ИЗ КОЖЕВЕННОГО СЫРЬЯ

Номер: RU0000198645U1

Автор: Аниканов Александр Васильевич, Артюшкова Елена Борисовна, Гладченко Михаил Петрович, Жеребилов Николай Иванович, Смахтин Михаил Юрьевич, Фурман Юрий Васильевич

Принадлежит: федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации

Полезная модель относится к оборудованию для жидкостной обработки кожевенного сырья, используемого для получения коллагена. Устройство для получения коллагена из кожевенного сырья состоит из двух емкостей: внешней, в которой проводят технологические операции, и внутренней - меньшего диаметра, в которую помещают сырье для обработки, стенки и дно ее имеют отверстия диаметром 10-15 мл, мешалки, электродвигателя, трубопроводов для подачи и слива воды и реагентов, нагревательного прибора. Устройство работает следующим образом: Во внутреннюю емкость помещают кожевенное сырье (гольевую обрезь), а во внешнюю емкость через нижний трубопровод подают воду для проведения операции промывки кожевенного сырья. После операции обессоливания сырье подвергают гидротермообработке в 2-3%-ном растворе пероксида водорода. Конструкция устройства позволяет четко выдержать временные ограничения проведения операции. Далее в емкость подают раствор щелочи для разволокнения молекул коллагена. Предлагаемая полезная модель позволяет быстрее и значительно эффективнее получить коллаген, требуемого качества. 1 ил. И 1 198645 ко РОССИЙСКАЯ ФЕДЕРАЦИЯ 7 ВУ” 198 645? 91 ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ИЗВЕЩЕНИЯ К ПАТЕНТУ НА ПОЛЕЗНУЮ МОДЕЛЬ ММ9К Досрочное прекращение действия патента из-за неуплаты в установленный срок пошлины за поддержание патента в силе Дата прекращения действия патента: 05.05.2020 Дата внесения записи в Государственный реестр: 30.08.2021 Дата публикации и номер бюллетеня: 30.08.2021 Бюл. №25 Стр.: 1 па 9479361 ЕП

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Номер записи: 11

19-08-2020 дата публикации

УСТРОЙСТВО ДЛЯ СИНТЕЗА БЕЛКОВ В БЕСКЛЕТОЧНОЙ СИСТЕМЕ

Номер: RU0000199182U1

Автор: Бирюков Сергей Владимирович

Принадлежит: Федеральное государственное бюджетное учреждение науки Институт белка Российской академии наук (ИБ РАН)

Полезная модель относится к области молекулярной биологии и биотехнологии. Устройство для синтеза белков в бесклеточной системе содержит реакционную ячейку с первым и вторым пористыми барьерами, образующими объем с реакционной смесью. Насосы обеспечивают подачу раствора питающей смеси в реакционный объем и отвод раствора продуктов синтеза. Устройство дополнительно содержит внешнюю по отношению к реакционной ячейке жидкостную коммуникацию, которая соединяет вход и выход реакционного объема с помощью последовательно соединенных первого и второго крана и насоса. Данная жидкостная коммуникация позволяет обеспечить частичную или полную смену реакционной смеси в ячейке и продлить эффективный синтез целевых белков. 6 з.п. ф-лы, 1 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК C12M 1/12 C12M 1/14 C12P 21/00 C07K 1/02 (11) (13) 199 182 U1 (2006.01) (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК C12M 1/12 (2020.02); C12M 1/14 (2020.02); C12P 21/00 (2020.02); C07K 1/02 (2020.02) (21)(22) Заявка: 2019140794, 10.12.2019 (24) Дата начала отсчета срока действия патента: 19.08.2020 Приоритет(ы): (22) Дата подачи заявки: 10.12.2019 (45) Опубликовано: 19.08.2020 Бюл. № 23 1 9 9 1 8 2 R U (54) УСТРОЙСТВО ДЛЯ СИНТЕЗА БЕЛКОВ В БЕСКЛЕТОЧНОЙ СИСТЕМЕ (57) Реферат: Полезная модель относится к области внешнюю по отношению к реакционной ячейке молекулярной биологии и биотехнологии. жидкостную коммуникацию, которая соединяет Устройство для синтеза белков в бесклеточной вход и выход реакционного объема с помощью системе содержит реакционную ячейку с первым последовательно соединенных первого и второго и вторым пористыми барьерами, образующими крана и насоса. Данная жидкостная объем с реакционной смесью. Насосы коммуникация позволяет обеспечить частичную обеспечивают подачу раствора питающей смеси или полную смену реакционной смеси в ячейке и в реакционный объем и отвод раствора продуктов продлить эффективный синтез ...

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Номер записи: 12

03-03-2021 дата публикации

Устройство для получения коллагена из кожевенного сырья.

Номер: RU0000202701U1

Автор: Александр Владимирович Файтельсон, Алексей Анатольевич Крюков, Виктор Станиславович Недзведский, Елена Борисовна Артюшкова, Николай Иванович Жеребилов, Юрий Васильевич Фурман

Принадлежит: Федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации

Полезная модель относится к оборудованию для жидкостной обработки отходов шкур животных, образующихся в кожевенном производстве.Технический результат достигается тем, что внутренняя емкость устройства, в которую помещают исходное сырье для обработки, дополнительно оборудована прессом для проведения операции отжима обработанного сырья.Устройство работает следующим образом:Во внутреннюю емкость, помещают кожевенное сырье (гольевую обрезь), а во внешнюю емкость, через нижний трубопровод подают воду для проведения операции промывки кожевенного сырья, обработанное сырье отжимают прессом для удаления избытка воды и реагентов. Обработанное сырье подвергают гидротермообработке в 2-3% растворе пероксида водорода. Использование пресса для отжима сырья позволяет более точно выдержать временные ограничения проведения операции. Далее в емкость подают раствор щелочи для разволокнения молекул коллагена.Предлагаемая полезная модель позволяет быстрее и значительно эффективнее получить коллаген, требуемого качества. (Илл. 1.). РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 202 701 U1 (51) МПК C14C 15/00 (2006.01) C07K 1/36 (2006.01) C07K 14/78 (2006.01) B01F 7/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК C14C 15/00 (2021.01); C07K 1/36 (2021.01); B01F 7/00 (2021.01) (21)(22) Заявка: 2020135782, 30.10.2020 (24) Дата начала отсчета срока действия патента: Дата регистрации: 03.03.2021 R U 2 0 2 7 0 1 U 1 Адрес для переписки: 305041, Курская обл., г. Курск, ул. Карла Маркса, 3, Лазаренко Виктор Анатольевич (56) Список документов, цитированных в отчете о поиске: RU 2066351 C1, 10.09.1996. RU 2609635 C1, 02.02.2017. RU 2049110 C1, 27.11.1995. EP 3440228 B1, 13.05.2020. U 1 (45) Опубликовано: 03.03.2021 Бюл. № 7 (73) Патентообладатель(и): федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации (RU) 2 0 ...

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Номер записи: 13

12-01-2012 дата публикации

Gastrin releasing peptide compounds

Номер: US20120009122A1

Автор: Adrian D. Nunn, Edmund Marinelli, Enrico Cappelletti, Karen E. Linder, Kondareddiar Ramalingam, Luciano Lattuada, Michael F. Tweedle, Natarajan Raju, Palaniappa Nanjappan, Rolf E. Swenson

Принадлежит: BRACCO IMAGING SPA

New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.

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Номер записи: 14

12-01-2012 дата публикации

Methods of predicting responsiveness to interferon treatment and treating hepatitis c infection

Номер: US20120009148A1

Автор: Yoav Smith

Принадлежит: Yissum Research Development Co of Hebrew University of Jerusalem

Provided are methods of predicting responsiveness of a subject to interferon treatment, comprising comparing a level of expression in a cell of the subject of at least one gene selected from the group consisting KIR3DL3, KIR3DL2, KIR3DL1, KIR2DL1, KIR2DL2, KIR2DL3, KLRG1, KIR3DS1, CD160, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G and IFI27 to a reference expression data of the at least one gene obtained from at least one interferon responder subject and/or at least one interferon non-responder subject. Also provided are methods and pharmaceutical compositions for treating a subject in need of interferon treatment.

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Номер записи: 15

12-01-2012 дата публикации

Immunoglobulin variants with altered binding to protein a

Номер: US20120009182A1

Автор: Henry B. Lowman, Yik Andy Yeung

Принадлежит: Genentech Inc

Variant immunoglobulins with one or more amino acid modifications in the VH region that have altered binding to Staphylococcus aureus protein A, and methods of using the same are provided.

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Номер записи: 16

12-01-2012 дата публикации

Monoparamunity inducers based on attenuated rabbit myxomaviruses

Номер: US20120009217A1

Автор: Anton Mayr, Barbara Mayr

Принадлежит: Individual

The present invention relates to monoparamunity inducers based on paramunizing viruses or viral components of a myxomavirus strain from rabbits with typically generalizing disease, to a method for the production thereof and to the use thereof as medicaments for the regulatory optimization of the paramunizing activities for the prophylaxis and therapy of various dysfunctions in humans and animals.

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Номер записи: 17

12-01-2012 дата публикации

Respiratory Syncytial Virus Antigenic Compositions and Methods

Номер: US20120009254A1

Автор: James Gorham Boyd, Thomas J. Powell

Принадлежит: Artificial Cell Technologies Inc

Multilayer films comprise polypeptide epitopes from RSV. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films include at least one designed peptide that includes one or more polypeptide epitopes from RSV. Specifically, the multilayer films include two polypeptide epitopes from RSV, such as an epitope that elicits a specific T-cell response such as a cytotoxic T-cell response, and an epitope that elicits a specific antibody response.

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Номер записи: 18

12-01-2012 дата публикации

Metabolically Engineered Bacterial Strains Having Non-Functional Endogenous Gluconate Transporters

Номер: US20120009635A1

Автор: Fernando Valle, M. Harunur Rashid, Manoj Kumar, Timothy C. Dodge

Принадлежит: DANISCO US INC

The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.

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Номер записи: 19

12-01-2012 дата публикации

Use of Molecular Chaperones for the Enhanced Production of Secreted, Recombinant Proteins in Mammalian Cells

Номер: US20120009670A1

Автор: Hsinyi Yvette Tang, Ruth Kelly, Sham-Yuen Chan, Yiwen Tao, Yongjian Wu

Принадлежит: Bayer Pharmaceuticals Corp

The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.

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Номер записи: 20

12-01-2012 дата публикации

Natriuretic activities

Номер: US20120010142A1

Автор: John C. Burnett, Jr., Timothy M. Olson

Принадлежит: Mayo Foundation for Medical Education and Research

This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding polypeptides having a natriuretic peptide activity, host cells containing such nucleic acids, and methods for inducing a natriuretic or diuretic activity within a mammal are provided.

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Номер записи: 21

12-01-2012 дата публикации

"Methods of Reducing Nephrotoxicity in Subjects Administered Nucleoside Phosphonates"

Номер: US20120010170A1

Автор: George R. Painter

Принадлежит: Individual

A conjugate compound comprising an acyclic nucleoside phosphonate covalently coupled to a lipid for the therapeutic and/or prophylactic treatment of viral infection in an immunodeficient subject is described, along with compositions and methods of using the same. A preferred conugate compound is CMX001, having formula (I) or a pharmaceutically acceptable salt thereof.

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Номер записи: 22

12-01-2012 дата публикации

Composition comprising various proteorhodopsins and/or bacteriorhodopsins and use thereof

Номер: US20120010333A1

Автор: Bradley R. Kelemen, Gregory M. Whited, II Donald E. Ward, Rasmus B. Jensen, Richard R. Bott

Принадлежит: DANISCO US INC, Genencor International Inc

The present invention provides a solid material comprising an immobilized mixture of two or more proteorhodopsins, two or more bacteriorhodopsins, or one or more bacteriorhodopsin and one or more proteorhodopsins. The proteorhodopsins are selected from the group consisting of all-trans-retinal-containing proteorhodopsins and retinal analog-containing proteorhodopsins; all of which have absorption spectra that do not overlap. The bacteriorhodopsins are selected from the group consisting of all-trans-retinal-containing bacteriorhodopsins and retinal analog-containing bacteriorhodopsins; all of which have absorption spectra that do not overlap. The present invention also provides an optical information carrier, such as an optical data storage material and a fraud-proof optical data carrier, comprising the above-described solid material and a substrate selected from the group consisting of glass, paper, metal, fabric material, and plastic material, wherein said solid material is deposited on said substrate. The present invention further provides security ink comprising one or more hydrophilic polymers and a mixture of various photochromic materials.

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Номер записи: 23

19-01-2012 дата публикации

Influenza virus detection and diagnosis

Номер: US20120015346A1

Автор: Doris J. Bucher, Manojkumar Ramanunninair

Принадлежит: New York Medical College

The invention discloses compositions comprising nucleic acid(s) for rapid detection, identification, differentiation, and/or diagnosis of certain Influenza virus A subtypes, e.g., H1N1, H3N2 and A(2009 H1N1)pdm, and methods of use thereof, e.g., Short-run RT-PCR, including an RT-PCR assay kit, comprising the disclosed composition(s).

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Номер записи: 24

19-01-2012 дата публикации

Anti-polyethylene glycol antibody expressing cell quantify any free polyethylene glycol and polyethylene glycol-derivatized molecules

Номер: US20120015380A1

Автор: Kuo-Hsiang Chuang, Ssu-Jung Lu, Steven R. Roffler, Tian-Lu Cheng

Принадлежит: KAOHSIUNG MEDICAL UNIVERSITY

In this invention, anti-PEG antibodies or anti-methoxyl-PEG (anti-CH 3 O-PEG) antibodies were expressed on cell surface which can collocate with a biotinylated anti-PEG antibody (AGP4-Biotin) or biotinylated PEG (PEG-Biotin) to develop a cell-based sandwich ELISA or a cell-based competition ELISA, respectively. Both of these two methods could sensitively quantify free PEG and PEG-modified macromolecules (proteins, nanoparticles and liposomes) as sensitive as nano-gram level.

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Номер записи: 25

19-01-2012 дата публикации

Novel inhibitors of retroviral reverse transcriptace

Номер: US20120015874A1

Автор: Daniel Michalowski, Donald H. Burke-Aguero

Принадлежит: University of Missouri System

Disclosed are nucleic acid molecules, and methods of their use, which have a specific structure including a double helical domain and a G-quadruplex domain physically connected by a linker domain which may be nucleosidic or non-nucleosidic. These aptamers demonstrate potent inhibition of phylogenetically diverse primate lentiviral reverse transcriptases, which effect is largely independent of aptamer sequence provided that the aptamer has the specified structure.

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Номер записи: 26

19-01-2012 дата публикации

Isolated novel nucleic acid and protein molecules from corn and methods of using those molecules to generate transgene plants with enhanced agronomic traits

Номер: US20120017292A1

Автор: Bo-Xing Qiu, David K. Kovalic, Jack E. Tabaska, Wei Wu

Принадлежит: MONSANTO TECHNOLOGY LLC

This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants.

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Номер записи: 27

19-01-2012 дата публикации

Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics

Номер: US20120017330A1

Автор: Cory Christensen, Kenneth A. Feldman, Nestor Apuya

Принадлежит: Ceres Inc

Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants with increased tolerance to abiotic stress (e.g., high or low temperature, drought, flood).

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Номер записи: 28

19-01-2012 дата публикации

Process for the production of arachidonic acid and/or eicosapentaenoic acid

Номер: US20120017332A1

Автор: Johnathan A. Napier, Olga Sayanova

Принадлежит: BASF Plant Science GmbH

The present invention relates to a new process for the production of arachidonic acid and/or eicosapentaenoic acid in plants through the co-expression of a Δ-12-/Δ-15-desaturase, Δ-9-elongase, Δ-8-desaturase and a Δ-5-desaturase and a process for the production of lipids or oils having an increased content of unsaturated fatty acids, in particular ω-3 and ω-6 fatty acids having at least two double bonds and a 18 or 20 carbon atom chain length. Preferably the arachidonic acid and eicosapentaenoic acid are produced in at least a 1:2 ratio. The invention furthermore relates to the production of a transgenic plants, preferably a transgenic crop plant, having an increased content of arachidonic acid and/or eicosapentaenoic acid, oils or lipids containing C 18 - or C 20 -fatty acids with a double bond in position Δ5, 8, 9, 11, 12, 14, 15 or 17 of the fatty acid produced, respectively due to the expression of the Δ-12-/Δ-15-desaturase, of the Δ-9-elongase, of the Δ-8-desaturase and of the Δ-5-desaturase in the plant. The expression of the inventive Δ-12-/Δ-15-desaturase leads preferably to linoleic acid and linolenic acid as products having a double bond in the position

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Номер записи: 29

26-01-2012 дата публикации

Preparative chromatography column and methods

Номер: US20120018380A1

Автор: Sarfaraz K. Niazi

Принадлежит: Therapeutic Proteins Inc

A chromatography column that captures components in a process liquid in a free flow state and allows elution in steps is described.

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Номер записи: 30

26-01-2012 дата публикации

Methods and compositions for liver cancer therapy

Номер: US20120020961A1

Автор: Anne-Sophie Dume, Dominique Joubert, Frédéric HOLLANDE, Leïla Houhou

Принадлежит: Biorealites SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Institut National de la Sante et de la Recherche Medicale INSERM

The present disclosure provides methods of treating liver cancer and preventing liver cancer recurrence with anti-progastrin antibodies, methods of monitoring treatment efficacy of anti-progastrin therapy for liver cancer, and compositions useful therefore.

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Номер записи: 31

26-01-2012 дата публикации

Antibodies against fatty acid synthase

Номер: US20120020978A1

Автор: Patrick J. Muraca

Принадлежит: Nuclea Biotechnologies Inc

The present invention relates to antibodies that immunospecifically bind to FAS and certain FAS related proteins. The invention encompasses human and humanized forms of the antibodies and their use in treating cancers and other proliferative disorders. The invention also relates to FAS-derived peptides useful for preparing the antibodies. Methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other proliferative disorders using the present antibodies also are disclosed.

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Номер записи: 32

26-01-2012 дата публикации

Vaccine

Номер: US20120020993A1

Автор: Joann Lisa Prior, Rachel Elizabeth Dean, Sarah Victoria Harding, Timothy Phillip Atkins

Принадлежит: UK Secretary of State for Defence

The present invention relates to a pharmaceutical formulation comprising lipopolysaccharide derived from Burkholderia thailandensis and its various uses, including but not limited to its use in the treatment and/or prophylaxis of meliodosis or amelioration of symptoms associated therewith, and/or glanders or amelioration of symptoms associated therewith.

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Номер записи: 33

26-01-2012 дата публикации

Process for making dry and stable hemostatic compositions

Номер: US20120021058A1

Автор: Andreas Goessl

Принадлежит: Baxter Healthcare SA, Baxter International Inc

Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a dry granular preparation of a biocompatible polymer suitable for use in hemostasis, b) coating the granules in said dry granular preparation with a preparation of a coagulation inducing agent, thereby obtaining coagulation inducing agent coated polymer granules, c) filling said coagulation inducing agent coated polymer granules into a final container, d) finishing the final container to a storable pharmaceutical device containing said coagulation inducing agent coated polymer granules as a dry and stable hemostatic composition.

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Номер записи: 34

26-01-2012 дата публикации

DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKER Nato3

Номер: US20120021417A1

Автор: Tomoya Nakatani, Yasuko Nakagawa, Yoshimasa Sakamoto, Yuichi Ono

Принадлежит: Eisai R&D Management Co Ltd

The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of a Nato3 gene, or a complementary sequence thereto, and an antibody against a Nato3 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.

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Номер записи: 35

26-01-2012 дата публикации

Recombinant FcRn and Variants Thereof for Purification of Fc-Containing Fusion Proteins

Номер: US20120021484A1

Автор: Kevin A. McDonnell

Принадлежит: BIOGEN IDEC MA INC

The invention is directed to methods of purifying Fc-containing molecules using a soluble neonatal Fc receptor (sFcRn). Native FcRn binds Fc-containing proteins at or below about pH 6.5 and releases them at or above about pH 7 and provides a much milder approach for capturing and purifying Fc-containing proteins, in particular, therapeutic Fc-containing proteins. Other embodiments of the invention provide modifications to alter the pH for binding and elution to the sFcRn, to modulate Fc-containing protein binding affinity, to affect sFcRn linkage to a support surface, or to improve the stability of sFcRn to conditions utilized in the methods of the invention.

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Номер записи: 36

26-01-2012 дата публикации

Genetic markers for risk management of atrial fibrillation and stroke

Номер: US20120021989A1

Автор: Daniel Gudbjartsson, Hilma Holm

Принадлежит: DECODE GENETICS EHF

The invention relates to procedures and methods of determining a susceptibility to cardiac arrhythmia, including Atrial Fibrillation, Atrial Flutter and Stroke, by assessing the presence or absence of alleles at polymorphic markers found to be associated with risk of these conditions. The invention further relates to kits encompassing reagents for assessing such markers, and diagnostic 5 methods, uses and procedures for utilizing such susceptibility markers.

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Номер записи: 37

02-02-2012 дата публикации

Genetically programmable pathogen sense and destroy

Номер: US20120027786A1

Автор: Ron Weiss, Saurabh Gupta

Принадлежит: Massachusetts Institute of Technology

Aspects of the invention relate to compositions and methods for using recombinant cells to sense and destroy specific pathogens.

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Номер записи: 38

02-02-2012 дата публикации

Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids

Номер: US20120028322A1

Автор: Andrew Hawkins, Aristos Aristidou, Catherine Asleson Dundon, Doug Lies, Lynne H. Albert

Принадлежит: Gevo Inc

The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces Glade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

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Номер записи: 39

02-02-2012 дата публикации

Methods and compositions comprising tau oligomers

Номер: US20120029169A1

Автор: Eliot J. Davidowitz, James G. Moe

Принадлежит: Oligomerix Inc

Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neuronal axons. In the disease process tau protein becomes modified, loses its affinity to microtubules and accumulates in the cell body where it forms aggregates. The large neurofibrillary tangles formed from tau protein assembled into filaments were thought to be the pathological structure of tau. However, more recent work indicates that smaller, soluble oligomeric forms of tau are best associated with neuron loss and memory impairment. Here, novel compositions of tau oligomers and novel mechanisms for tau oligomer nucleation, extension and termination are taught. Methods for producing and purifying these structures for the development of small molecule and immunotherapeutics as well as antibodies for biomarkers of neurodegenerative diseases are taught.

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Номер записи: 40

09-02-2012 дата публикации

Influenza Vaccines, Antigens, Compositions, and Methods

Номер: US20120034253A1

Автор: Konstantin Musiychuk, Vadim Mett, Vidadi Yusibov

Принадлежит: Fraunhofer USA Inc

The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and compositions useful in inducing or enhancing an immune response agains influenza antigens. Provided are recombinant protein antigens, compositions, and methods for the production of such antigens in plants. In some embodiments, influenza antigens include hemagglutinin polypeptides, neuraminidase polypeptides, and/or combinations thereof.

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Номер записи: 41

09-02-2012 дата публикации

Method for obtaining a singular cell model capable of reproducing in vitro the metabolic idiosyncrasy of humans

Номер: US20120034642A1

Автор: Agustín Lahoz Rodríguez, José Vicente Castell Ripoll, María José Gómez-Lechón, Ramiro Jover Atienza

Принадлежит: Advancell Advanced In Vitro Cell Technologies SA

The method is based on the use of expression vectors coding for the sense and anti-sense mRNA of the Phase I and Phase II drug biotransformation enzymes showing a greatest variability in humans for transforming cells expressing reductase activity. Such vectors can modulate (increase or decrease) the individualized expression of an enzyme without affecting the other enzymes. This singular cell model can reproduce in vitro the metabolic idiosyncrasy of humans. It is applicable in the study of development of new drugs, specifically in the study of metabolism, potential idiosyncratic hepatotoxicity, medicament interactions, etc., of new drugs.

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Номер записи: 42

09-02-2012 дата публикации

Method for the Targeted Integration of Multiple Copies of a Gene of Interest in a Yarrowia Strain

Номер: US20120034652A9

Автор: Cécile NEUVEGLISE, Franck Fudalej, Jean-Marc Nicaud, Jean-Marie Beckerich

Принадлежит: Individual

This invention concerns a method for the targeted integration of at least three copies of a gene of interest in the genome of a Yarrowia strain including the steps of: (a) cultivating a Yarrowia strain, said strain including a deletion among at least three genes, the phenotype associated with each of these deletions corresponding to an auxotrophy or to a dominant character for this strain; (b) transforming said Yarrowia strain thus obtained with at least three recombinant vectors that include selection markers allowing, for this strain, the complementation of auxotrophy and, potentially, of the dominant character resulting from each of these deletions; and (c) selecting, on a minimum medium, the yeasts having integrated said at least three recombinant vectors. This invention also includes a method for producing a polypeptide of interest using this method as well as a method for obtaining a modified Yarrowia strain including a deletion among at least three genes, the phenotype associated with each of these deletions corresponding to an auxotrophy or to a dominant character for this strain.

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Номер записи: 43

09-02-2012 дата публикации

Fsh producing cell clone

Номер: US20120034655A1

Автор: Nanni Jelinek, Stefan Arnold

Принадлежит: BIOGENERIX GMBH

The present invention relates to nucleic acid molecules comprising a nucleic acid sequence coding for the α- and the β-chain of the human follicle stimulating hormone (FSH), respectively, which has been modified with respect to the codon usage in CHO cells. The present invention further relates to a recombinant nucleic acid molecule comprising such nucleic acid sequences and host cells containing such recombinant nucleic acid molecules, as well as their use in the production of recombinant human FSH. Finally, the present invention also relates to a method for producing host cells expressing human follicle stimulating hormone by transfecting cells in suspension culture under serum-free conditions with the recombinant nucleic acid molecule of the present invention.

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Номер записи: 44

09-02-2012 дата публикации

Vaccine

Номер: US20120036589A1

Автор: Alexandra Adams, Kim Thompson, Saravanane Poobalane

Принадлежит: University of Stirling

The present invention is concerned with the development of a vaccine against Aeromonas hydrophila for use especially in fish. The invention provides an immunogenic S-layer protein of approximately 50 kDa of A. hydrophila for use in the development of a vaccine, as well as the nucleic acid encoding said protein and vaccines comprising said protein or nucleic acid encoding said protein.

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Номер записи: 45

09-02-2012 дата публикации

Cold-Tolerant Plants

Номер: US20120036597A1

Автор: Chin-Fen Su, Su-May Yu

Принадлежит: Academia Sinica

Disclosed are chill- or cold-tolerant plants and methods of making the plants. Also disclosed are methods for identifying a plant that is tolerant to chill.

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Номер записи: 46

16-02-2012 дата публикации

Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (mva)

Номер: US20120039936A1

Автор: Paul Howley, Sonja Leyrer

Принадлежит: Individual

The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA sequence inserted into said new insertion site as medicine or vaccine.

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Номер записи: 47

16-02-2012 дата публикации

Compositions and methods for vaccine and virus production

Номер: US20120039939A1

Автор: Chia Chu, Joseph Shiloach, Michael Betenbaugh, Pratik Jaluria

Принадлежит: JOHNS HOPKINS UNIVERSITY

The present invention features methods of producing immunogenic compositions and viruses, methods of treating and preventing viral infection, and methods of producing an immune response using cells that express a polypeptide selected from the group consisting of: cdk13, siat7e, Iama4, cox15, egr1, gas6, map3k9, and gap43, and a virus.

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Номер записи: 48

16-02-2012 дата публикации

Isoamyl acetate for weight management

Номер: US20120040046A1

Автор: Alexander Erin, Johannes Le Coutre, Julie Laure Hudry

Принадлежит: Nestec SA

Described is the use of isoamyl acetate in food compositions for weight management and/or weight control. Further described is a beverage containing isoamyl acetate.

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Номер записи: 49

16-02-2012 дата публикации

Novel collagen materials and methods for obtaining same

Номер: US20120040119A1

Автор: Christian Gagnieu, Patricia Forest, Sylvain Picot

Принадлежит: BiomUp France SAS

The invention relates to novel collagen materials and, specifically, collagen membranes, tubes and threads. Said materials combine enhanced properties of resilience and strength. The invention also relates to a method for preparing collagen materials using acid fibrous collagen comprising coagulation and, optionally, cross-linking of the collagen in the presence of ammonia gas.

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Номер записи: 50

16-02-2012 дата публикации

Identification of Porcine Reproductive and Respiratory Syndrome Virus

Номер: US20120040335A1

Автор: Craig Welbon, Elizabeth M. Brown, Eric A. Nelson, Ying Fang

Принадлежит: South Dakota State University

An enzyme-linked immunosorbent assay (ELISA) is based on the non-structural protein 7 (nsp7) of porcine reproductive and respiratory syndrome virus (PRRSV) and provides for the simultaneous detection and differentiation of serum antibodies directed against Type 1 (European) and Type 2 (North American) PRRSV. The invention provides a serological assay for the detection and/or differentiation of serum antibodies directed against Type 1 and/or Type 2 PRRSV utilizing PRRSV nsp7 as an antigen, and provides a diagnostic method for the detection of PRRSV infection, epidemiological surveys, and outbreak investigations. The invention may be used either alone or as a follow-up assay to determine the true status of unexpected positive results that may occur using other assays, such as the IDEXX HERDCHEK PRRS ELISA.

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Номер записи: 51

16-02-2012 дата публикации

Lung cancer diagnostic polypeptide, method for detecting lung cancer, and method for evaluating therapeutic effect

Номер: US20120040376A1

Автор: Atsuhiko Toyama, Hidewaki Nakagawa, Koji Ueda, Taka-Aki Sato

Принадлежит: RIKEN Institute of Physical and Chemical Research, Shimadzu Corp

A novel biomarker for use in lung cancer diagnosis is provided.

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Номер записи: 52

16-02-2012 дата публикации

Mini-Hepcidin Peptides and Methods of Using thereof

Номер: US20120040894A1

Автор: Elizabeta Nemeth, Gloria Preza, Piotr Ruchala, Tomas Ganz

Принадлежит: UNIVERSITY OF CALIFORNIA

Disclosed herein are peptides which exhibit hepcidin activity and methods of making and using thereof.

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Номер записи: 53

16-02-2012 дата публикации

Novel autography regulators atg14l and rubicon

Номер: US20120041175A1

Автор: Zhenyu Yue

Принадлежит: Mount Sinai School of Medicine, ROCKEFELLER UNIVERSITY

The present invention provides for up- and down-regulation of cellular autophagy, e.g., for treating cancer or neurological disease. The invention results, in part, from discovery of two novel proteins, ATG14L (previously called “BISC”) and Rubicon (previously called “BIRC”), which bind to a Class III phophatidylinositol 3′-kinase (PI3K)/Vps34-Beclin 1 autophagic complex. ATG14L and Rubicon each regulate autophagic activity in an opposing manner. ATG14L and Rubicon can be used, for example, to increase/decrease autophagic activity, to increase/decrease PI3K/Vps34 kinase activity, and in so doing, treat diseases and disorders, such as cancer, neurodegenerative disease, stroke, metabolic disease, and age-related disease. ATG14L can increase autophagic activity and PI3K/Vps34 kinase activity; and Rubicon can decrease autophagic activity and PI3K/Vps34 kinase activity.

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Номер записи: 54

16-02-2012 дата публикации

Antibody fusion-mediated plant resistance against Oomycota

Номер: US20120042416A1

Автор: Dieter Peschen, Rainer Fischer, Stefan Schillberg, Sylvia Schleker

Принадлежит: Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV

The present invention relates to fusion proteins comprising anti-Oomycotic proteins or peptides linked to an antibody or fragment thereof specifically recognising an epitope of an Oomycota. The invention is also directed to polynucleotides coding for the fusion proteins. The embodiments of the present invention are particularly useful for the protection of plants against Oomycota. The invention therefore comprises transgenic plants expressing the fusion proteins of the present invention.

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Номер записи: 55

23-02-2012 дата публикации

Long-Term Storage of Non-Glycosylated Recombinant Human G-CSF

Номер: US20120042613A1

Автор: Helmut Lerch, Klaus Graumann, Thomas Lauber

Принадлежит: SANDOZ AG

The present invention provides a method for stable long-term storage of non-glycosylated recombinant human G-CSF, wherein an aqueous acetate or glutamate buffered G-CSF composition containing non-glycosylated recombinant human G-CSF and sorbitol is cooled to a temperature of −15° C. or below to obtain a frozen G-CSF composition, which frozen composition is then stored in the frozen state. The temperature of the frozen G-CSF composition is later increased to a temperature within the range of from 2° C. to 8° C. for a time selected to allow the G-CSF composition to thaw and to obtain a liquid G-CSF composition having a G-CSF content of at least 95% of the G-CSF content of the original composition.

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Номер записи: 56

23-02-2012 дата публикации

Human papilloma virus peptide-specific T-cell response for treatment of warts

Номер: US20120045413A1

Автор: Kevin Kim, Mayumi Nakagawa, Thomas Horn

Принадлежит: Kevin Kim, Mayumi Nakagawa, Thomas Horn

The inventors have treated human patients for warts by intralesional injection of Candida antigen to induce a delayed-type hypersensitivity response in the patients. This creates an immune response that recognizes the antigens of the human papilloma virus (HPV) found in and causing the warts. It was found that the patients showed a response to HPV type 57 L1 peptide 380-412 (a peptide consisting of amino acid residues 380-412 of the protein L1) and HPV type 57 protein E4 (E4 10-30). One embodiment of the invention provides a pharmaceutical composition comprising a polypeptide comprising (a) L1 380-412 (SEQ ID NO:3) or a fragment of at least 8 residues of SEQ ID NO:3 or (b) E4 10-30 (SEQ ID NO:4) or a fragment of at least 8 residues of E4 10-30 (SEQ ID NO:4), wherein the composition is immunogenic in humans.

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Номер записи: 57

23-02-2012 дата публикации

Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof

Номер: US20120045464A1

Автор: J. Neil Simonsen

Принадлежит: Individual

Cloning and expression of genes encoding C. parvum antigenic polypeptides are described as are antibodies that recognize epitopes on these polypeptides. The antigenic polypeptides and antibodies thereto can be used in therapeutic compositions for the prevention and treatment of C. parvum infections, as well as in diagnostic methods for determining the presence of C. parvum infections.

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Номер записи: 58

23-02-2012 дата публикации

Biomolecule Surface Display and Uses Thereof

Номер: US20120045473A1

Автор: Jimmy Kwang

Принадлежит: Temasek Life Sciences Laboratory Ltd

A vaccine for the treatment or prevention of a disease in a subject, wherein said disease is associated with an avian influenza virus, and wherein said vaccine comprises an expression vector comprising a nucleic acid encoding a hemagglutinin peptide, such that in use said hemagglutinin peptide is expressed by said expression vector in said subject.

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Номер записи: 59

23-02-2012 дата публикации

Substrate peptide sequences for plague plasminogen activator and uses thereof

Номер: US20120045474A1

Автор: Anton Agarkov, Pedro Lory, Sadhana Chauhan, Scott R. Gilbertson, Vladimir L. Motin

Принадлежит: Individual

The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis . Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.

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Номер записи: 60

23-02-2012 дата публикации

Thermosensitive hepatitis b vaccine

Номер: US20120045511A1

Автор: Ho-Yuan Chou, Hsin-Hsin Shen, Mi-Hua Tao, Tsai-Yu Lin

Принадлежит: Industrial Technology Research Institute ITRI

A thermosensitive hepatitis B vaccine is provided. The thermosensitive hepatitis B vaccine includes an aqueous phase solution comprising a biodegradable thermosensitive hydrogel copolymer; a surface antigen of hepatitis B virus (HBsAg); and a bioactive substance. The thermosensitive hepatitis B vaccine of the disclosure is particularly suitable for being applied in the patients, which are low responsive or non-responsive to conventional hepatitis B vaccine, for enhancing the induction of cell-mediated immune responses and overcoming the HBsAg non-responsiveness.

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Номер записи: 61

23-02-2012 дата публикации

TREATMENT OF CELIAC DISEASE WITH IgA

Номер: US20120045517A1

Автор: Mark Andrew Kroenke, Michael Richard Simon

Принадлежит: Individual

A process for inhibiting symptoms of a subject with celiac disease is provided that includes administration of monoclonal-, or polyclonal-, monomeric, dimeric, or polymeric IgA. Joining secretory component to the IgA limits oral administration degradation. Formulating agents are mixed with the monomeric, dimeric, or polymeric IgA to yield a dosing form of a capsule, tablet, and a suppository. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating.

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Номер записи: 62

23-02-2012 дата публикации

Expression constructs comprising fungal promoters

Номер: US20120045793A1

Автор: Jennifer L. Shock, Louis Clark

Принадлежит: Codexis Inc

The present invention provides promoters derived from a filamentous fungus. These promoters have application in the fields of molecular biology, microbiology, fungal genetics and production of biofuels and other products.

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Номер записи: 63

23-02-2012 дата публикации

Enzyme-Based Fed-Batch Technique In Liquid Cultures

Номер: US20120045836A1

Автор: Antii Vasala, Antje Neubauer, Peter Neubauer

Принадлежит: BIOSILTA OY

The present invention is generally in the field of continuous and high-cell-density cultivation in laboratory- or large-scale liquid shaken cultures. More particularly it relates to a method of enzyme-based fed-batch (EnBase) for liquid microbial prokaryotic or eukaryotic cell cultivation having the possibility to manipulate the growth rate of the cultured organisms by a controlled enzymatic release of the growth-limiting substrate-monomer from substrate-polymers or substrate-oligomers.

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Номер записи: 64

01-03-2012 дата публикации

Anti-vegf-c antibodies and methods using same

Номер: US20120052566A9

Автор: Anil D. Bagri, Chingwei V. Lee, Germaine Fuh

Принадлежит: F Hoffmann La Roche AG

The invention provides VEGF-C antagonists, such as anti-VEGF-C antibodies, and their use in the prevention and treatment of tumor progression.

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Номер записи: 65

01-03-2012 дата публикации

Method for temporally controlling the biological activity of proteins in vertebrates, and applications thereof

Номер: US20120052570A1

Автор: Daniel Metzger, Huimin Zhao, John Katzenellenbogen, Pierre Chambon

Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Universite De Strasbourg, University of Illinois

The present invention relates to a method for tightly temporally controlling the biological activity of a protein of interest in a vertebrate, upon induction of the activity of a fusion protein comprising said protein of interest and an ERM polypeptide containing a mutated ligand binding domain of the human oestrogen receptor α, with a synthetic ligand that does not interfere with oestrogen signalling. In particular, the present invention concerns a method for generating tightly temporally-controlled targeted somatic mutations in a vertebrate, preferably a mouse, by inducing the activity of a fusion protein comprising a site-specific recombinase protein and an ERM polypeptide, with a synthetic ligand devoid of oestrogenic and anti-oestrogenic activities.

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Номер записи: 66

01-03-2012 дата публикации

Method for preparing protein, dna, and rna from cell

Номер: US20120053329A1

Автор: Nobuko Yamamoto

Принадлежит: Canon Inc

An object of the present invention is to prepare DNA, RNA, and a protein from one cell and to provide a convenient preparation method with high reproducibility. To prepare a protein, DNA, and RNA from a cell, nuclear and cytoplasmic separation is performed, and a protein, DNA, and RNA are then extracted.

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Номер записи: 67

08-03-2012 дата публикации

Msp nanopores and related methods

Номер: US20120055792A1

Автор: Jens H. Gundlach, Mark A. Troll, Michael Niederweis, Mikhail PAVLENOK, Thomas Z. BUTLER

Принадлежит: UAB RESEARCH FOUNDATION, UNIVERSITY OF WASHINGTON

Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.

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Номер записи: 68

08-03-2012 дата публикации

method for promoting bone growth using activin-actriia antagonists

Номер: US20120058115A1

Автор: Jasbir Seehra, John Knopf

Принадлежит: Acceleron Pharma Inc

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.

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Номер записи: 69

08-03-2012 дата публикации

Lipid encapsulated interfering rna

Номер: US20120058188A1

Автор: Ellen Grace Ambegia, Ian Maclachlan, James Heyes

Принадлежит: PROTIVA BIOTHERAPEUTICS INC

The present invention provides compositions and methods for silencing gene expression by delivering nucleic acid-lipid particles comprising a siRNA molecule to a cell.

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Номер записи: 70

08-03-2012 дата публикации

Differential immunoassay for prrs vaccine antibody

Номер: US20120058466A1

Автор: Kyoung-Jin Yoon, Wai-Hong Wu

Принадлежит: Iowa State University Research Foundation ISURF

The present invention relates to immunoassays for serologically differentiating animals naturally infected with PRRS virus from animals vaccinated against PRRS. The immunoassays provide detection of at least a portion of the N terminal region of the 2b portion of PRRSV. The immunoassay is preferably an enzyme-linked immunosorbent assay (ELISA).

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Номер записи: 71

08-03-2012 дата публикации

Phosphonate Compounds

Номер: US20120058975A1

Автор: Ganesh D. Kini, James R. Beadle, Karl Y. Hostetler

Принадлежит: UNIVERSITY OF CALIFORNIA

The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.

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Номер записи: 72

08-03-2012 дата публикации

Methods for preparing stable deoxygenated peg-hemoglobin conjugate solutions comprising an antioxidant

Номер: US20120059153A1

Автор: Ashok S. Malavalli, Kim D. Vandegriff

Принадлежит: Sangart Inc

The present invention is a method for preparing stable HBOC solutions. Specifically, the method comprises the steps of deoxygenating a PEG-Hb conjugate and adding one or more antioxidants during or following the deoxygenating step to form a stabilized PEG-Hb conjugate. The Hb in the PEG-Hb conjugate is not crosslinked and the stabilized PEG-Hb conjugate has a p50 less than that of native SFH from the same animal source when measured under the same conditions. Specifically, the p50 is 6±2 mmHg or less than 10 mmHg.

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Номер записи: 73

15-03-2012 дата публикации

Peptidomimetic protease inhibitors

Номер: US20120064034A1

Автор: Cristina Garcia-Paredes, Deqi Guo, Frantz Victor, Ivan Collado, Jason Eric Lamar, John Irvin Glass, LING Jin, Luc Farmer, Mark Joseph Tebbe, Nancy June Snyder, Q. May Wang, Raymond Samuel Parker, Iii, Robert B. Perni, Robert Edward Babine, Shu Hui Chen, Xicheng David Sun, Yvonne Yee Mai Yip

Принадлежит: Vertex Pharmaceuticals Inc

The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

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Номер записи: 74

15-03-2012 дата публикации

Monoclonal Antibodies to Hepatocyte Growth Factor

Номер: US20120064066A1

Автор: Kyung Jin Kim, Yi-Chi Su

Принадлежит: Galaxy Biotech LLC

The present invention is directed toward a neutralizing monoclonal antibody to hepatocyte growth factor, a pharmaceutical composition comprising same, and methods of treatment comprising administering such a pharmaceutical composition to a patient.

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Номер записи: 75

15-03-2012 дата публикации

Aminoacyl trna synthetases for modulating hematopoiesis

Номер: US20120064082A1

Автор: Alain P. Vasserot, Jeffry Dean Watkins, Leslie Ann Greene, Rajesh Belani, Ryan Andrew Adams

Принадлежит: aTyr Pharma Inc

Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.

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Номер записи: 76

15-03-2012 дата публикации

Combinations including pneumococcal serotype 14 saccharide

Номер: US20120064104A1

Автор: Paolo Costantino

Принадлежит: NOVARTIS AG

Meningococcal lipooligosaccharide and pneumococcal serotype 14 capsular saccharide share an antigen that can cross-react with human tissue. The invention provides various ways of minimising the production of autoreactive antibodies when these two antigens are co-administered.

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Номер записи: 77

15-03-2012 дата публикации

Use of e. coli surface antigen 3 sequences for the export of heterologous antigens

Номер: US20120064114A1

Автор: Jonathan Telfer, Mark Richard Redfern

Принадлежит: Emergent Product Development UK Ltd

The present invention provides an export signal system based on E. coli CS3 antigen for directing the secretion of foreign antigens from host cells. In particular, the invention describes genetic constructs encoding fusion proteins that contain a CS3 export signal fused to at least one heterologous amino acid sequence. Attenuated microorganisms expressing the fusion proteins and pharmaceutical compositions comprising such attenuated microorganisms are also disclosed.

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Номер записи: 78

15-03-2012 дата публикации

Tetravalent influenza vaccine and use thereof

Номер: US20120064117A1

Автор: Hairong Lu, Ted M. Ross, Xianchun Tang

Принадлежит: University of Pittsburgh

Disclosed herein is the finding that baculovirus display of multiple influenza virus hemagglutinin (HA) proteins elicits broadly reactive immune responses against influenza. Thus provided herein are recombinant baculovirus vectors having a first, second, third and fourth nucleic acid sequence, each encoding an influenza hemagglutinin (HA) fusion protein. The first, second, third and fourth nucleic acid sequences each encode an influenza HA with a different amino acid sequence. Also provided are recombinant baculoviruses displaying a first, second, third and fourth influenza virus HA fusion protein in the baculovirus envelope, wherein each HA fusion protein comprises a different HA amino acid sequence. Tetravalent influenza virus vaccines comprising the recombinant baculoviruses disclosed herein are further provided. In addition, methods of immunizing a subject against influenza virus using the tetravalent influenza virus vaccines are provided. In particular examples of the compositions and methods disclosed herein, the HA polypeptides are from H5N1 influenza virus.

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Номер записи: 79

15-03-2012 дата публикации

assay for detecting vitamin d and antibodies therefor

Номер: US20120064533A1

Автор: David Pritchard, Lars Orning, Margaret Lawlor, Murdo Black

Принадлежит: Axis Shield Diagnostics Ltd

A molecule which recognises holo-DBP but which does not recognise apo-DBP or has relatively low affinity thereto.

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Номер записи: 80

15-03-2012 дата публикации

Recombinant factor viii having enhanced stability following mutation at the a1-c2 domain interface

Номер: US20120065136A1

Автор: Hironao Wakabayashi, Philip J. Fay

Принадлежит: UNIVERSITY OF ROCHESTER

The invention relates to a recombinant factor VIII that includes one or more mutations at an interface of A1 and C2 domains of recombinant factor VIII. The one or more mutations include substitution of one or more amino acid residues with either a cysteine or an amino acid residue having a higher hydrophobicity. This results in enhanced stability of factor VIII. Methods for making the recombinant factor VIII, pharmaceutical compositions containing the recombinant factor VIII, and use of the recombinant factor VIII for treating hemophilia A are also disclosed.

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Номер записи: 81

15-03-2012 дата публикации

Use of the gtpase rab27b to diagnose and treat poor prognosis estrogen-receptor-positive breast cancer

Номер: US20120065147A1

Автор: An Hendrix, Olivier De Wever, Wendy Westbroek

Принадлежит: Individual

The present invention relates to evaluating the prognosis of patients with estrogen receptor-positive breast cancer on the basis of Rab27B expression. The invention further relates to a kit comprising an assay for measuring Rab27B levels in said patients and to the usage of Rab27B as a target to screen for drugs capable of inhibiting or diminishing metastasis of said cancer. Furthermore, the invention discloses compounds which can be used to treat estrogen receptor-positive breast cancer.

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Номер записи: 82

15-03-2012 дата публикации

Dragline protein

Номер: US20120065372A1

Автор: Masao Nakagaki, Tianfu ZHAO, Yujun Wang

Принадлежит: Okamoto Corp

To provide a new natural fiber material with excellent physical properties. Any one of the following nucleic acids (a) to (d): (a) a nucleic acid having a base sequence of SEQ ID NO: 1 or 19; (b) a nucleic acid encoding a protein having an amino acid sequence of SEQ ID NO: 2 or 20; (c) a nucleic acid encoding a dragline protein and having a sequence identity of 90% or more with the nucleic acid (a); (d) a nucleic acid which encodes a dragline protein and hybridizes with a complementary chain of the nucleic acid (a) under stringent conditions.

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Номер записи: 83

15-03-2012 дата публикации

Methods of processing recombinant procollagen

Номер: US20120065376A1

Автор: Amit Yaari, Hanan Stein, Michal Rosenthal, Oded Shoseyov, Or Dgany, Tamar Haya Tal

Принадлежит: Collplant Ltd

A method of generating atelocollagen is disclosed. The method comprises contacting a human telopeptide-comprising collagen with a protease selected from the group consisting of neutrase, subtilisin, ficin recombinant human trypsin and recombinant human pepsin, wherein said human telopeptide-comprising collagen is expressed in a non-animal cell, thereby generating the atelocollagen. Compositions comprising the atelocollagen generated thereby are also disclosed.

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Номер записи: 84

15-03-2012 дата публикации

Test agent for visceral obesity and use thereof

Номер: US20120066777A1

Автор: Atsunori Kashiwagi, Hiroshi Maegawa, Masatomo Rokushima, Minoru Ikeda, Minoru Suzuki, Shiro Maeda, Tatsuya Takahashi, Tohru Tani, Yoshihiro Kawamura

Принадлежит: RIKEN Institute of Physical and Chemical Research, Shiga University of Medical Science NUC, Shionogi and Co Ltd

Disclosed are: a method for detecting (diagnosing) visceral obesity in a subject; a test agent useful for the method; a method for searching for a substance that can be used as an active ingredient for ameliorating visceral obesity; and an ameliorating agent for visceral obesity or a medicinal agent for preventing a metabolic disease developed as a result of the progression of visceral obesity. As the test agent, a polynucleotide which comprises at least 15 nucleotides and can hybridize with a nucleotide sequence for coiled-coil domain containing protein 3 (CCDC3) gene or a nucleotide sequence complementary to the nucleotide sequence under stringent conditions or an antibody capable of recognizing CCDC3 protein is used.

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Номер записи: 85

15-03-2012 дата публикации

Methods and compositions for controlling plant pests

Номер: US20120066793A1

Автор: Daniel John Tomso, Kimberly S. Sampson

Принадлежит: Athenix Corp

Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:13-24 or the nucleotide sequence set forth in SEQ ID NO:1-12 and 25-44, as well as variants and fragments thereof.

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Номер записи: 86

22-03-2012 дата публикации

Extracellular yaluronidase from streptomyces koganeiensis

Номер: US20120070441A1

Автор: Giovanni Gennari, Luciano Messina, Salvatore Caruso, Susana Vaccaro

Принадлежит: KETER PLASTIC LTD

The invention relates to Streptomyces koganeiensis ATCC 31394 hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date. The invention further relates to a process for the isolation and purification of said hyaluronidase and its use for the preparation of pharmaceutical compositions or as an analytical reagent.

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Номер записи: 87

22-03-2012 дата публикации

Combination therapy for treatment of fiv infection

Номер: US20120070489A1

Автор: Ben M. Dunn, Janet K. Yamamoto, Maki Arai

Принадлежит: Individual

The present invention pertains to methods for therapeutic and prophylactic treatment of cats against FIV infection. Methods of the present invention utilize a combination of antiretroviral compounds to treat or prevent FIV infection in a feline animal. In one embodiment, the method comprises administering an effective amount of AZT and another nucleoside analog, such as, for example, 3TC to the animal. In another embodiment, cats are given an effective dose(s) of AZT, 3TC, and a retroviral protease inhibitor.

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Номер записи: 88

22-03-2012 дата публикации

Soybean event mon89788 and methods for detection thereof

Номер: US20120070839A1

Автор: Ellen Dickinson, Jennifer Rinehart, Marianne Malven, Nancy Taylor

Принадлежит: Individual

The present invention provides for soybean plant and seed comprising transformation event MON89788 and DNA molecules unique to these events. The invention also provides methods for detecting the presence of these DNA molecules in a sample.

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Номер записи: 89

22-03-2012 дата публикации

Bacterial cells, optimized nucleotide sequences and methods for improved expression of recombinant clostridium difficile toxin b

Номер: US20120070859A1

Автор: Elaine E. Hamm, Jimmy D. Ballard, Jordi M. Melton

Принадлежит: University of Oklahoma

In some embodiments, the present invention provides isolated nucleotide sequences that encode Clostridium difficile toxin B, wherein the isolated nucleotide sequences have been optimized for improved expression of the toxin B in a bacterial cell. Other embodiments of the present invention pertain to methods of expressing recombinant Clostridium difficile toxin B in a bacterial cell from the isolated nucleotide sequences of the present invention. In other embodiments, the present invention pertains to bacterial cells that comprise the isolated nucleotide sequences of the present invention. In further embodiments, the invention pertains to isolated peptides of recombinant Clostridium difficile toxin B that were derived from the isolated nucleotide sequences of the present invention.

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Номер записи: 90

22-03-2012 дата публикации

Method For Enucleating Nucleated Erythrocyte, And Enucleation Inducer

Номер: US20120070897A1

Автор: Eriko Shimamura, Hiroki Shimada, Toshihisa Hatta

Принадлежит: KANAZAWA MEDICAL UNIVERSITY

Provided is a factor capable of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time. More particularly, provided are a method of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time by adding a compound derived from proopiomelanocortin (POMC) to an undifferentiated (nucleated) erythrocyte, and an enucleation inducer including the compound.

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Номер записи: 91

22-03-2012 дата публикации

Methods And Marker Combinations For Screening For Predisposition To Lung Cancer

Номер: US20120071334A1

Автор: Bhawani Singh, Eric L. Russell, Javier Ramirez, John C. Russell, Stephen Frost, Tracey Colpitts

Принадлежит: ABBOTT LABORATORIES

The present invention relates to rapid, sensitive methods for determining whether a subject has or is at risk of developing lung cancer based on certain combinations of biomarkers, or biomarkers and biometric parameters. The methods consist of: a) quantifying in a test sample obtained from a subject, the amount of two or more biomarkers in a panel, the panel comprising at least one antibody and at least one antigen: b) comparing the amount of each biomarker quantified in the panel to a predetermined cutoff for said biomarker and assigning a score for each biomarker based on said comparison: c) combining the assigned score for each biomarker quantified in step b to obtain a total score for said subject: d) comparing the total score in step c with a predetermined total score and e) determining whether said subject has a risk of lung cancer based on the comparison in step d.

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Номер записи: 92

22-03-2012 дата публикации

Modified vegf-a with improved angiogenic properties

Номер: US20120071406A1

Автор: Kari Alitalo, Katri Pajusola, Markku M. Jeltsch, Marko J. T. Uutela, Salla Keskitalo, Seppo Yla-Herttuala, Terhi Karpanen, Tuomas Tammela, Ulf Eriksson

Принадлежит: Vegenics Pty Ltd

The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.

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Номер записи: 93

22-03-2012 дата публикации

Therapeutic application of isolated naturally-occuring soluble truncated forms of IL-23 receptor

Номер: US20120071422A1

Автор: Grant Gallagher, Jonathan Brazaitis, Raymond Yu

Принадлежит: Medical Diagnostic Laboratories LLC

The present invention relates to an isolated naturally-occurring soluble truncated IL-23Rα protein, which is a translated protein resulting from a mRNA splice variant of IL-23Rα. The soluble IL-23Rα proteins (e.g., Δ9 and Δ8,9) represents a novel soluble IL-23Rα protein, which is lacking a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end (due to frame-shift). ELISA reveals that Δ9 is present in blood and can serve as a diagnostic tool for auto-immune diseases including Crohn's disease. There is also provided a method of recombinant production for this soluble truncated form of IL-23Rα protein. More importantly, the present invention provides an utility application of the Δ9 and Δ8,9 protein in inhibit IL-23R-mediated cell signaling. More particularly, Δ9 and Δ8,9 blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of Δ9 and Δ8,9 in treating a human patient inflicted with Crohn's disease.

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Номер записи: 94

22-03-2012 дата публикации

Lenalidomide and Thalidomide Immunoassays

Номер: US20120071632A1

Автор: Alexander Volkov, Howard Sard, Jodi Blake Courtney, Salvatore J. Salamone, Vishnumurthy Hegde

Принадлежит: Individual

Novel conjugates and immunogens derived from lenalidomide and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of thalidomide and lenalidomide in biological fluids.

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Номер записи: 95

22-03-2012 дата публикации

Prevention and treatment of blood coagulation-related disases

Номер: US20120073002A1

Автор: Hiroyuki Saito, Kazutaka Yoshihashi, Kunihiro Hattori, Takehisa Kitazawa

Принадлежит: Chugai Pharmaceutical Co Ltd

Provided herein is an animal having a persistent hypercoagulable state by implanting a cell, for example a tumor cell, in which the gene of human tissue factor is implanted to an experimental animal such as a mouse and then growing the cell, thereby persistently supplying human tissue factor to the experimental animal. This animal model is useful for research and development of therapeutic agents for diseases having a persistent hypercoagulable state. Also provided are preventive or therapeutic agents for diseases having a persistent hypercoagulable state, a hypercoagulable state resulting from infections, venous thrombosis, arterial thrombosis, and diseases resulting from the hypertrophy of vascular media, the agent comprising an antibody against human tissue factor (human TF) as an active ingredient.

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Номер записи: 96

29-03-2012 дата публикации

Human cytomegalovirus neutralising antibodies and use thereof

Номер: US20120076801A1

Автор: Annalisa Macagno, Antonio Lanzavecchia

Принадлежит: Humabs Llc

The invention relates to neutralizing antibodies and antibody fragments having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for a combination of hCMV proteins UL130 and UL131A, or for a combination of hCMV proteins UL128, UL130 and UL131A. The invention relates also to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis and therapy of disease.

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Номер записи: 97

29-03-2012 дата публикации

Combinations of pneumococcal rrgb clades

Номер: US20120076814A1

Автор: Michele Anne Barocchi, Monica Moschioni, Paolo Ruggiero, Vega Masignani

Принадлежит: NOVARTIS AG

Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain.

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Номер записи: 98

29-03-2012 дата публикации

Novel malaria vaccine

Номер: US20120076816A1

Автор: Ken Ishii, Takahiro Tougan, Toshihiro Horii

Принадлежит: Osaka University NUC

The present invention provides a vaccine for preventing and/or treating Plasmodium falciparum infections, which comprises a polypeptide set forth in SEQ ID NO: 1 or represented by formula (1), and an adjuvant. X 1 -A-B-X 2 -Y-X 3 -(Y)n-X 4 -(Y)n-X 5 (1) (In the formula, X 1 represents the 1st to 7th amino acid residues in a polypeptide set forth in SEQ ID NO: 1; X 2 represents the 73th to 177th amino acid residues; X 3 represents the 178th to 258th amino acid residues; X 4 represents the 259th to 289th amino acid residues; X 5 represents the 290th to 334th amino acid residues; A represents an 8-mer repeat sequence contained in a 47-kd region of SERA polypeptide of Plasmodium falciparum ; B represents a sequence of a serine-rich region contained in a 47-kd region of SERA polypeptide of Plasmodium falciparum ; Y represents any one selected from A-A, A-B, and B; and n is an integer of 0 or 1.)

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Номер записи: 99

29-03-2012 дата публикации

Method for removing viruses from high concentration monoclonal antibody solution

Номер: US20120077963A1

Автор: Masayasu Komuro, Tomoko Hongo

Принадлежит: Asahi Kasei Medical Co Ltd

An object of the present invention is to provide a method for removing even small viruses from a high concentration monoclonal antibody solution using a membrane, and thus for recovering the antibody within a short time at high yield in the form of a filtrate. The present invention provides a method for producing a preparation containing a monoclonal antibody, which comprises a step of removing viruses by filtering viruses in a monoclonal antibody solution using a virus-removing membrane, wherein (1) the monomer content of the monoclonal antibody accounts for 90% or more; (2) the monoclonal antibody concentration in the monoclonal antibody solution ranges from 20 mg/ml to 100 mg/ml; (3) the monoclonal antibody solution contains at least a basic amino acid; and (4) the parvovirus removal rate of the virus-removing membrane satisfies the following conditions: LRV (Log Reduction Value: logarithmic reduction value) ≧4.

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Номер записи: 100