06-06-1984 дата публикации
Номер: GB0002130590A
Автор:
de Castiglione, Roberto,
Gozzini, Luigia,
Montecucchi, Pier Carlo,
Perseo, Giuseppe,
DE CASTIGLIONE ROBERTO,
GOZZINI LUIGIA,
MONTECUCCHI PIER CARLO,
PERSEO GIUSEPPE,
ROBERTO * DE CASTIGLIONE,
LUIGIA * GOZZINI,
PIER CARLO * MONTECUCCHI,
GIUSEPPE * PERSEO
Принадлежит:
There are provided peptides of the formula X - A - B - C - Trp - D - Y wherein X is H, a terminal N atom protecting group of acyl, aromatic urethane, alkyl or aralkyl or aliphatic urethane type. A and D are independently a valence bond or a L- alpha -amino acid residue; B is a L- alpha -imino acid residue or a L- alpha -amino acid residue. C is a L- alpha -imino acid residue or a neutral L- alpha -amino acid residue, Y is OH, NH2, OR, NHR, NR2 or NH-NH-R'; R is a straight chain, branched chain or cyclic (including fused or bridged ring), substituted or unsubstituted C1- C11 alkyl group, phenyl, or C7-C9 aralkyl; R' is H, any value which R may have, C3-C8 alkenyl, a straight chain, branched chain or cyclic aliphatic C1-C11 acyl group) optionally substituted by OH, NH2, or a halogen atom), an aromatic acyl group similarly optionally substituted, a straight chain, branched chain or cyclic aliphatic C3-C11 urethane type group or an aromatic urethane type group. Pharmaceutically acceptable salts ...
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