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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 13701. Отображено 102.

20-03-1995 дата публикации

Номер: KR19950005915A

Автор:

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Номер записи: 1

14-03-1994 дата публикации

Номер: KR19940004014A

Автор:

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Номер записи: 2

05-01-2012 дата публикации

Non-focal optical power limiting polymeric materials

Номер: US20120002312A1

Автор: Abhijit Sarkar, George Rayfield, Salma Rahman, Shamim Mirza

Принадлежит: Oxazogen Inc

This invention concerns a solid polymer matrix for use as non-focal optical power limiting polymeric materials. This matrix contains: (1) a hyperbranched polymer family, especially HB-PCS OR HB-PU, HB-PUSOX or PC; (2) one or more of RSA dye, MPA dye, azo dye or DMNPAA; 3) CNT and 4) a self-focusing component. This solid polymer matrix provides efficient protection from laser beam damage along with its self-focusing mechanism.

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Номер записи: 3

20-10-2008 дата публикации

УСТРОЙСТВО ДЛЯ ПРОВЕДЕНИЯ ЛАБОРАТОРНЫХ РАБОТ

Номер: RU0000077274U1

Автор: Поваляев Олег Александрович, Фролов Виктор Петрович, Ярошевский Михаил Львович

Принадлежит: Общество с ограниченной ответственностью фирма "СНАРК"

1. Устройство для проведения лабораторных работ, содержащее магнитное основание, беговую дорожку в виде прямолинейного желоба со стенками и линейной шкалой, продольной магнитной полосой, каретку с глухими отверстиями, шкивы, секундомер, датчики, разборный штатив, крестообразную муфту, грузы, подвесные крючки, динамометр, измерительную пружину и подвесной крючок, рычаг с продольно расположенными отверстиями, контактно-чувствительный экран, шарик стальной, при этом устройство снабжено рабочей рейкой, на лицевой стороне которой выполнена основная беговая дорожка с плоским дном и стенками, к одной из которых примыкает горизонтальная продольная полка с овальным отверстием, причем отверстие выполнено в полке на большем расстоянии от одного края, чем от другого, в соотношении 0,73÷0,63, а внешняя сторона основания рейки снабжена дополнительной беговой дорожкой, выполненной в виде двух параллельных вертикальных направляющих с трамплином на одних концах, и двумя вертикальными ребрами, расположенными по разные стороны от дополнительной беговой дорожки, причем верхние торцы вертикальных ребер выполнены криволинейно-вогнутыми в центральной части с примыкающими к ней с двух сторон прямолинейными участками и примыкающим к одному прямолинейному участку скосом со стороны, противоположной трамплину, вертикальные направляющие выполнены с меньшей высотой, чем высота вертикальных ребер прямолинейных участков, снабженных выемками и примыкающими к выемкам и расположенными между вертикальными направляющими и ребрами опорными площадками с магнитными вставками, а в зоне скоса выполнены две внутренние плоские перемычки, к одной из которых примыкают другие торцы вертикальных направляющих; каретка снабжена двумя ушками, расположенными на ее торцах и выполненными в виде плоских вертикальных ребер со сквозным отверстием, и плоским боковым выступом с магнитной вставкой на его верхней стороне; грузы выполнены в виде параллелепипедов с сопрягаемыми между собой торцевыми зацепами, один из которых ...

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Номер записи: 4

23-02-2012 дата публикации

Pyrazole-based cyanine dye containing quaternary ammonium cation

Номер: US20120046474A1

Автор: Matsuhiro Date, Naoyuki Yamamoto, Satoshi Hasaba, Tatsuo Kurosawa

Принадлежит: Wako Pure Chemical Industries Ltd

Problem Provided is a novel cyanine dye derivative having high fluorescence intensity in a short wavelength region, a structure where a pyrazole skeleton and an indole skeleton are bound to a polymethine chain, and also a controllable migration velocity by further introducing a quaternary ammonium cation into a molecule having said structure. Solution The present invention is the invention of a compound represented by the general formula [1] or a salt thereof: [wherein R1 to R6 each independently represent an alkyl group having, as a substituent, a group represented by the general formula [101]: (wherein R101 to R104 each independently represent a hydrogen atom or an alkyl group of C1 to C3 and m represents an integer from 2 to 6, and two or three of R102 to R104 together with a nitrogen atom to which they are bound may form a heterocyclic ammonium cation); or a group derived from a carboxylic acid represented by the general formula [2] which may have an amide bond: —COOR12 [2] (wherein R12 represents a hydrogen atom, an alkyl group of C1 to C10, an alkali metal atom, an organic ammonium ion, an ammonium ion or anion); or an alkyl group which may have, as a substituent, a group derived from a sulfonic acid represented by the general formula [3] which may have an amide bond: —SO3R13 [3] (wherein R13 represents a hydrogen atom, an alkali metal atom, an organic ammonium ion, an ammonium ion or anion); R7 to R10 each independently represent an alkyl group, an alkynyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylsulfonyl group, an arylsulfonyl group, an amino group, a group derived from a carboxylic acid represented by the general formula [2], a group derived from a sulfonic acid represented by the general formula [3], a halogen atom, a hydrogen atom, a hydroxyl group, a cyano group or a nitro group; R11 represents a hydrogen atom, an alkyl group, an alkynyl group or an aryl group, and n represents an integer from 0 to 3, and at least one of R1 to ...

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Номер записи: 5

01-03-2012 дата публикации

Conjugated compound, and organic thin film and organic thin film element each comprising same

Номер: US20120049174A1

Автор: Makoto Okabe, Masato Ueda, Yoshio Aso, Yutaka Ie

Принадлежит: Osaka University NUC, Sumitomo Chemical Co Ltd

A conjugated compound having a group represented by formula (I) and/or formula (II). [In the formulas, Ar represents an optionally substituted trivalent aromatic hydrocarbon or optionally substituted trivalent heterocyclic group, and A represents hydrogen, a halogen atom or a monovalent group. When multiple A groups are present they may be the same or different, and at least one A represents an electron-withdrawing group. Ar′ represents an optionally substituted C6 or greater divalent aromatic hydrocarbon or optionally substituted C4 or greater divalent heterocyclic group, and R1 and R2 are the same or different and each represents hydrogen, a halogen atom or a monovalent group, while A′ represents hydrogen, a halogen atom or a monovalent group. When multiple A′ groups are present they may be the same or different, and at least one A′ represents an electron-withdrawing group.]

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Номер записи: 6

01-03-2012 дата публикации

Cyanine dyes

Номер: US20120052506A1

Автор: David Sun, Gene Shen, Stephen Yue

Принадлежит: Pacific Biosciences of California Inc

The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.

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Номер записи: 7

01-03-2012 дата публикации

Phospholinked dye analogs with an amino acid linker

Номер: US20120052507A1

Автор: Gene Shen

Принадлежит: Pacific Biosciences of California Inc

In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including muliple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.

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Номер записи: 8

25-10-2012 дата публикации

Small molecules that covalently modify transthyretin

Номер: US20120270938A1

Автор: Jeffery W. Kelly, Sungwook Choi

Принадлежит: Scripps Research Institute

A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more than 4000 other human plasma proteins is disclosed. A contemplated compound corresponds in structure to Formula I, below, where the various substituents are defined within, and reacts chemoselectively with one or two of four Lys-15 ε-amino groups within the transthyretin tetramer. The crystal structure confirms the binding orientation of the compound substructure and the conjugating amide bond. A covalent transthyretin kinetic stabilizer exhibits superior amyloid inhibition potency, compared to a non-covalent counterpart, and inhibits cytotoxicity associated with amyloidogenesis.

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Номер записи: 9

14-02-2013 дата публикации

Dye and coloring photosensitive composition

Номер: US20130041062A1

Автор: Keisuke Matsuhira, Masaaki Shimizu, Yosuke Maeda

Принадлежит: Adeka Corp

The present invention provides a dye that is excellent in solubility and excellent in heat resistance and a novel compound that is preferable for the dye, and specifically provides a yellow dye having a wavelength of maximum absorption in the region of 400 to 450 nm, and also provides a coloring (alkali-developable) photosensitive composition using the above-mentioned dye, and an optical filter using the above-mentioned coloring (alkali-developable) photosensitive composition, specifically a color filter that does not decrease luminance and thus is preferable for image display devices such as liquid crystal display panels. Specifically, a compound represented by the following general formula (1) is used as the dye. The content of the above-mentioned general formula (1) is as described in the description.

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Номер записи: 10

21-02-2013 дата публикации

Benzocyanine compounds

Номер: US20130045488A1

Автор: Boguslawa Dworecki, Frank G. Lehmann, Greg Hermanson, Marie Christine Nlend, Matthias S. Wenzel, Peter T. Czerney, Surbhi Desai

Принадлежит: Dyomics GmbH, Pierce Biotechnology Inc

Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

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Номер записи: 11

07-03-2013 дата публикации

Trimethine cyanine and its use

Номер: US20130060046A1

Автор: Cheng-Fen Yang, Chin-Kang Sha, Ching-Jung Chang, Hsin-Jen Lee

Принадлежит: ORGCHEM TECHNOLOGIES Inc

The present invention relates to a trimethine cyanine represented by the formula (1): wherein all symbols are defined as in the specification.

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Номер записи: 12

28-03-2013 дата публикации

Dye formulation for fabricating dye sensitized electronic devices

Номер: US20130074935A1

Автор: John C. Warner, Michael S. Viola

Принадлежит: Warner Babcock Institute for Green Chemistry LLC

Disclosed and claimed herein is an aqueous dye dispersion for making a dye sensitized electronic device having, a water insoluble dye, an alkalizing agent, a surfactant; and water. The water insoluble dye has at least one acid group and the aqueous dye dispersion is substantially free of volatile organic solvents, co-solvents and diluents. Further disclosed and claimed is a method of making a photoelectronic device using the claimed aqueous dye dispersion.

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Номер записи: 13

18-04-2013 дата публикации

DYE COMPOSITIONS AND DYE SYNTHESES

Номер: US20130095040A1

Автор: Mokkapati Umamaheshwar P.

Принадлежит: GE HEALTHCARE AS

The present invention relates to sulfonated unsymmetrical pentamethine optical dye compositions, especially dyes suitable for biological applications in vitro, and for in vivo imaging. Improved dye compositions and intermediates are provided, which enable the suppression of undesirable newly-identified impurities. Also provided is the use of the improved dye compositions in the preparation of conjugates with biological targeting molecules. 114-. (canceled)16. The composition of claim 15 , where Ris H.17. The composition of claim 15 , where Rto Rare independently CHor an Rgroup.19. The composition of claim 15 , which further comprises sulfonate ester derivatives of Formula A claim 15 , Bor C claim 15 , which correspond to the dyes of Formula A claim 15 , B or C respectively wherein at least one of Rand Ris —SO—OR claim 15 , where Ris Calkyl or an Rgroup; Ris an Ror Rgroup; Ris Csulfoalkyl; and Ris Ccarboxyalkyl; such that the molar ratio of A: (A+B+C) is at least 92:1.24. A method comprising reaction of the composition of with an alkylating agent of formula R—X claim 23 , where Ris an Rgroup; Ris Calkyl or an Rgroup; Ris an Ror Rgroup; Ris Csulfoalkyl; Ris Ccarboxyalkyl; and X is a leaving group.26. A pharmaceutical composition which comprises the composition of claim 15 , in a biocompatible carrier medium claim 15 , in sterile form suitable for mammalian administration. The present invention relates to the field of sulfonated unsymmetrical pentamethine optical dyes, especially dyes suitable for biological applications in vitro, and for in vivo imaging. Improved dye compositions and intermediates are provided, which enable the suppression of undesirable newly-identified impurities.The sulfonation of dyes by the introduction of sulfonate (—SOH or —SO) substituents is an established method of increasing the water solubility of the dye.WO 2005/044923 and US 2007/0203343 A1 disclose the synthesis of new class of sulfonated pentamethine and heptamethine cyanine dyes ...

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Номер записи: 14

18-04-2013 дата публикации

SYNTHESIS OF AZO BONDED IMMUNOREGULATORY COMPOUNDS

Номер: US20130096286A1

Автор: Ekwuribe Nnochiri N., Riggs-Sauthier Jennifer A.

Принадлежит:

Methods are disclosed for preparing compounds of Formula I: 3. The method of claim 1 , wherein the nitrile or amide is hydrolyzed to the carboxylic acid using acid catalysis.4. The method of claim 1 , wherein the nitrile or amide is hydrolyzed to the carboxylic acid using basic catalysis.5. The method of claim 1 , wherein the nitrile or amide is hydrolyzed to the carboxylic acid using enzymatic catalysis.6. The method of claim 1 , wherein the isolation step involves enzymatic resolution of one of the enantiomers during the hydrolysis of a nitrile or amide group.7. The method of claim 1 , wherein R claim 1 , R claim 1 , and Rare independently selected from the group consisting of H claim 1 , CH claim 1 , CHCH claim 1 , and CH(CH).8. The method of claim 1 , wherein R claim 1 , R claim 1 , and Rare independently selected from the group consisting of H claim 1 , CH claim 1 , CHCH claim 1 , and CH(CH).9. The method of claim 1 , wherein Ris selected from the group consisting of H claim 1 , CH claim 1 , CHCH claim 1 , and CH(CH).10. The method of claim 1 , wherein the compound that is formed is 5-(4-carboxymethyl-phenylazo)-2-hydroxy-benzoic acid claim 1 , 5-[4-(1-carboxy-ethyl)-phenylazo]-2-hydroxy-benzoic acid or 4-(4-carboxymethyl-phenylazo)-phenylacetic acid. This application is a divisional application of U.S. patent application Ser. No. 13/094,135 filed on Apr. 26, 2011, now U.S. Pat. No. 8,314,214 which in turn was a divisional application of Ser. No. 11/631,582, filed on Jan. 4, 2007, now U.S. Pat. No. 7,932,366, which in turn was filed under the provisions of 35 U.S.C. §371 and claimed priority of International Patent Application No. PCT/US2005/024109, filed on Jul. 7, 2005, and which in turn claimed priority of U.S. Provisional Application No. 60/585,995 filed on Jul. 7, 2004.1. Field of the InventionThe present invention relates to immunoregulatory compounds, methods of producing same and methods of treating diseases therewith.2. Background of the InventionMany ...

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Номер записи: 15

25-04-2013 дата публикации

BENZINDOCYANINE COMPOUND FOR LABELING SUBSTANCE, INTERMEDIATE THEREOF, AND METHOD FOR PREPARING THE SAME

Номер: US20130102752A1

Автор: Chung Doo-Young, Na Jong Joo, Park Jin Woo

Принадлежит: DKC CORPORATION

The present disclosure relates to a novel benzindocyanine compound for labeling biomolecules and a method for preparing the same. 3. The benzindocyanine compound according to claim 1 , wherein the fluorescence wavelength range of the compound represented by Chemical Formula 1 is 500-800 nm.4. The benzindocyanine compound according to claim 1 , wherein the compound represented by Chemical Formula 1 is labeled at a biomolecule claim 1 , a nanoparticle or an organic compound having an amino group claim 1 , a hydroxyl group or a thiol group.5. The benzindocyanine compound according to claim 4 , wherein the biomolecule is one selected from a group consisting of protein claim 4 , peptide claim 4 , carbohydrate claim 4 , sugar claim 4 , fat claim 4 , antibody claim 4 , proteoglycan claim 4 , glycoprotein and siRNA.7. The method for labeling a substance according to claim 6 , wherein the labeling of the substance is achieved via binding between a vinyl sulfone group of the compound and the amino group claim 6 , hydroxyl group or thiol group of the biomolecule claim 6 , nanoparticle or organic compound.8. The method for labeling a substance according to claim 6 , wherein the biomolecule is one selected from a group consisting of protein claim 6 , peptide claim 6 , carbohydrate claim 6 , sugar claim 6 , fat claim 6 , antibody claim 6 , proteoglycan claim 6 , glycoprotein and siRNA.9. The method for labeling a substance according to claim 6 , wherein a buffer selected from a group consisting of phosphate buffer claim 6 , carbonate buffer and Tris buffer claim 6 , an organic solvent selected from a group consisting of dimethyl sulfoxide claim 6 , dimethylformamide and acetonitrile claim 6 , or water is used as a solvent.10. The method for labeling a substance according to claim 6 , wherein the labeling is achieved at pH 5-12.11. The method for labeling a substance according to claim 6 , wherein the labeling is achieved by reacting the compound with the biomolecule claim 6 , ...

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Номер записи: 16

09-05-2013 дата публикации

FLUORESCENCE QUENCHING AZO DYES, THEIR METHODS OF PREPARATION AND USE

Номер: US20130116415A1

Автор: BEHLKE Mark Aaron, Laikhter Andrei, Roberts Kevin William, Walder Joseph, Yong Yawfui

Принадлежит: INTEGRATED DNA TECHNOLOGIES, INC.

Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the compositions, and kits comprising the composition. 2. The method of claim 1 , wherein either Ror Ris a cyanoethylphosphoramidite group.3. The method of claim 1 , wherein either Ror Ris a phosphoramidite group.4. The method of claim 3 , wherein the oligonucleotide is labeled on its 3′-terminus.5. The method of claim 4 , wherein the oligonucleotide is labeled on its 5′-terminus.7. The method of claim 1 , wherein the synthesis step comprises linking the compound of Formula 1 to a solid support.8. The method of claim 7 , wherein the solid support is controlled pore glass.9. The method of claim 1 , further comprising:obtaining a first compound having a nitro group and a primary amino group;treating the primary amino group of the first compound in the presence of NaNO2, followed by LiBF4, to form an diazonium salt;reacting the diazonium salt with a second compound having a substituted aryl ring to form the compound of Formula 1. This application is a continuation of U.S. application Ser. No. 13/298,479 filed Nov. 17, 2011, which is a divisional of U.S. application Ser. No. 12/252,721 filed Oct. 16, 2008, now U.S. Pat. No. 8,084,588, which is a divisional of U.S. application Ser. No. 10/987,608 filed Nov. 12, 2004, now U.S. Pat. No. 7,439,341, which claims priority benefits to U.S. Provisional Application No. 60/520,077 filed Nov. 14, 2003. These applications are incorporated herein by reference in their entirety.This invention pertains to compositions that are capable of quenching the fluorescence of fluorophores and to methods for making and using them. The invention also provides kits that contain at least one of the disclosed quencher compositions.Light quenching processes that rely on the interaction of two dyes as their spatial relationship changes can be used in convenient processes for detecting and/or ...

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Номер записи: 17

16-05-2013 дата публикации

DISPERSE DYES

Номер: US20130117947A1

Автор: Desai Nikhil, Desai Pankaj, Himeno Kiyoshi, Patel Jay

Принадлежит: COLOURTEX INDUSTRIES LIMITED

The present invention is directed to a disperse dye of formula (1) Wherein, X, Y and Z are, independently, hydrogen, halogen, cyano, nitro or SOF; Wherein at least one of X, Y and Z is SOF. Ris hydrogen, methyl, hydroxyl or NHR; Ris hydrogen, chloro or methoxy; Ris hydrogen, (C-C)-alkyl or —CH(CH)COOCHCN; Ris hydrogen, (C-C)-alkyl or —CH(CH)COOCHCN; Ris —COCH, —CO CH, —SOCHor SOCH; n and m are independently 0,1 or 2, with the proviso: When, Y and Z both are Cl, Ris other than methyl. When, Ris Hydrogen and R, Rboth are alkyl, Ris selected from NHSOCHor NHSOCH. Disperse dyes of Formula (I) have excellent washing fastness and light fastness on polyester fiber and polyester blends. 8. A disperse dye composition according to comprising an azo dye of formula (1) or a mixture thereof claim 1 , dispersing agent in the range of 80% to 400% by weight of the dye mixture claim 1 , and optionally a wetting agent in the range for 0.1% to 20% by weight of the dye mixture.9. Dyed material according to as a single component or in combination of two or more dyestuffs. The present invention relates to novel disperse dyes and use thereof.Traditionally, disperse dyes are used for dyeing synthetic fibers and its blend with other fibers such as cellulose, polyurethane, nylon and wool by usual exhaust dyeing, continuous dyeing and printing techniques.Indian Patent application 2162/KOLNP/2009 which is the Indian Equivalent of WO2008074719 and entitled “Disperse dye mixtures” discloses mixtures of disperse azo dyes with anthraquinone or benzodifuranone dyes for the colouration of synthetic textile materials. The said patent emphasizes on the disperse dyes mixtures to achieve desired fastness properties.Indian Patent number: IN 190551 (1700/DEL/94) which is the Indian equivalent of WO950200014 relates to monoazo dyes and a process for colouring synthetic textile materials, to synthetic textiles when coloured, to a process for the mass coloration of plastics, to plastics when coloured, to ...

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Номер записи: 18

16-05-2013 дата публикации

DYE COMPOSITIONS AND DYE SYNTHESES

Номер: US20130121926A1

Автор: ACHANATH Radha, Balaji Srinath, Johansen John Henrik

Принадлежит: GE HEALTHCARE AS

The present invention relates to sulfonated optical dye compositions, especially dyes suitable for biological applications in vitro, and for in vivo imaging. Improved dye compositions and intermediates are provided, which enable the suppression of undesirable newly-identified impurities. Also provided is the use of the improved dye compositions in the preparation of conjugates with biological targeting molecules. 116.-. (canceled)18. The precursor composition of claim 17 , where Yis —CRR—.19. The precursor composition of claim 17 , where q is 1 or 2.21. The precursor composition of claim 20 , where z is 1.26. Use of the intermediate composition of in the synthesis of a sulfonated dye.27. A pharmaceutical composition which comprises the dye composition of claim 22 , in a biocompatible carrier medium claim 22 , in sterile form suitable for mammalian administration.28. Use of the dye composition of or a pharmaceutical composition which comprises the dye composition of claim 22 , in a biocompatible carrier medium claim 22 , in sterile form suitable for mammalian administration claim 22 , in the preparation of a conjugate of the unsymmetrical dye of Formula IV with a biological targeting moiety or a synthetic macromolecule.29. The use of claim 28 , where the biological targeting moiety is chosen from:(i) a 3-100 mer peptide;(ii) an enzyme substrate, enzyme antagonist or enzyme inhibitor;(iii) a receptor-binding compound;(iv) an oligonucleotide;(v) an oligo-DNA or oligo-RNA fragment. The present invention relates to the field of sulfonated optical dyes, especially dyes suitable for biological applications in vitro, and for in vivo imaging. Improved dye compositions and intermediates are provided, which enable the suppression of undesirable newly-identified impurities.The sulfonation of dyes by the introduction of sulfonate (—SOH or —SO) substituents is an established method of increasing the water solubility of the dye.WO 01/43781 discloses the synthesis of new class of ...

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Номер записи: 19

16-05-2013 дата публикации

POLYLACTIC ACID RESIN SHEET AND MOLDED ARTICLE

Номер: US20130123404A1

Автор: ISHII Takeshi, Matsumoto Taisei, Tabata Hisataka

Принадлежит: Toray Industries, Inc.

A polylactic acid based resin sheet includes a layer formed of a composition (D) containing polylactic acid (A), an ionic surface active agent (B), and a nonionic surface active agent (C), wherein 1. A polylactic acid based resin sheet comprising a layer formed of a composition (D) containing polylactic acid (A) , an ionic surface active agent (B) , and a nonionic surface active agent (C) , whereincontent of the polylactic acid (A) is 50 mass % or more and 99.5% or less in the entire 100 mass % of the composition (D), andmass ratio, (B)/(C), between the ionic surface active agent (B) and the nonionic surface active agent (C) satisfies 2≧(B)/(C)≧20.2. The polylactic acid based resin sheet as defined in claim 1 , whereinthe ionic surface active agent (B) has a sulfo group, and 'aliphatic alkanol amide, polyglycerin fatty acid ester, higher alcohol (i), alkyl phenol (ii), fatty acid ester (iii), aliphatic amine (iv), aliphatic amide (v), polypropylene glycol (vi), sorbitan fatty acid ester (vii), and ethylene oxide adducts of (i) to (vii).', 'the nonionic surface active agent (C) is at least one selected from the following group consisting of3. The polylactic acid based resin sheet as defined in claim 1 , having a haze value of 10% or less.4. The polylactic acid based resin sheet as defined in claim 1 , having a wetting tension of 40 mN/m or more.5. The polylactic acid based resin sheet as defined in claim 1 , wherein the impact strength modifier contained accounts for 2 mass % or more and 20 mass % or less in the entire 100 mass % of the composition (D).6. The polylactic acid based resin sheet as defined in claim 1 , adapted to be processed by hot-plate-direct-heating-type vacuum molding or hot-plate-direct-heating-type vacuum air-pressure molding.7. A molded product produced from a polylactic acid based resin sheet as claimed in .8. The polylactic acid based resin sheet as defined in claim 2 , having a haze value of 10% or less.9. The polylactic acid based resin ...

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Номер записи: 20

23-05-2013 дата публикации

POROUS COORDINATION POLYMER, PROCESS FOR PRODUCING SAME, GAS STORAGE METHOD, AND GAS SEPARATION METHOD

Номер: US20130129608A1

Автор: Coquet Rudy, Kitagawa Susumu, Oshima Shinji, Watanabe Daisuke

Принадлежит: JX NIPPON OIL & ENERGY CORPORATION

The porous coordination polymer of the invention contains metal complexes formed by coordination bonding between a trivalent metal ion and an aromatic tricarboxylic acid represented by formula (1). The porous coordination polymer also has a pore structure formed by integration of a plurality of the metal complexes. 2. The porous coordination polymer according to claim 1 , wherein the pore volume is at least 0.1 cmper gram of the porous coordination polymer. The present invention relates to a porous coordination polymer, to a process for producing it, to a gas storage method and to a gas separation method.In recent years, porous coordination polymers have become a target of interest as new porous materials (see Non-patent document 1 below, for example). Porous coordination polymers are structures with pore structures formed by integration of metal complex molecules, and they are also known as integrated metal complexes (see Patent document 1, for example). Porous coordination polymers generally permit design and control of more uniform micropores than porous materials such as zeolite or active carbon.The present inventors first investigated porous coordination polymers employing aluminum ions, as the metal ions in porous coordination polymers. As a result, it was found that such porous coordination polymers have a high specific surface area and high pore volume. However, the porous coordination polymers still have room for improvement from the standpoint of affinity for gases (especially hydrogen gas).It is an object of the present invention, which has been accomplished in light of these circumstances, to provide a porous coordination polymer having a high specific surface area and high pore volume, and improved affinity for gases (especially hydrogen gas), as well as a process for producing it, and a gas storage method and gas separation method using the porous coordination polymer.According to a first aspect of the invention there is provided a porous coordination ...

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Номер записи: 21

23-05-2013 дата публикации

Fluorescent Probe for Imaging Lymph Nodes

Номер: US20130129631A1

Автор: Aoki Akira, Fujinami Masanori, Hayashi Hideki, Muraki Yutaka, Onoue Kazuki, Tamura Yutaka, Toyota Taro

Принадлежит: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY

Disclosed is a near-infrared fluorescent imaging agent comprising an indocyanine-based fluorescent dye and a liposome. The near-infrared fluorescent imaging agent of the present invention demonstrates high fluorescence intensity and a long anchoring time in sentinel lymph nodes, thereby making it useful for detecting sentinel lymph nodes in sentinel lymph node navigation surgery. Also disclosed is an indocyanine green derivative that is particularly suitable for use in the near-infrared fluorescent imaging agent of the present invention. 1. A fluorescent probe for near-infrared fluorescent imaging in sentinel lymphadenography comprising a liposome containing a fluorescent dye having a hexatriene skeletal structure.4. The fluorescent probe for near-infrared fluorescent imaging in sentinel lymphadenography according to claim 1 , wherein the particle diameter of the liposome is 100 nm to 300 nm.5. The fluorescent probe for near-infrared fluorescent imaging in sentinel lymphadenography according to claim 1 , wherein the particle diameter of the liposome is 150 nm to 250 nm.8. A method for identifying a sentinel lymph node comprising detecting fluorescence generated from the fluorescent probe according to .15. A liposome comprising the compound according to . The present application claims priority on the basis of Japanese Patent Application No. 2010-124252 (filed on May 31, 2010), the contents of which are incorporated herein by reference.The present invention relates to near-infrared fluorescent imaging of biological tissue.Sentinel lymph nodes refer to lymph nodes that directly receive the flow of lymph from the primary lesion of a tumor, and are believed to be the location where lymph node metastasis first occurs. In surgical excision for early-stage cancer, a procedure known as sentinel lymph node navigation surgery is becoming increasingly common. The procedure comprises identifying the sentinel lymph node using a dye or radioactive colloid, excising the lymph node ...

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Номер записи: 22

30-05-2013 дата публикации

Process for preparing structured organic films (sofs) via a pre-sof

Номер: US20130137033A1

Автор: Adrien Pierre Cote, Matthew A. HEUFT

Принадлежит: Xerox Corp

A processes for preparing structured organic film (SOF) comprising a plurality of segments and a plurality of linkers arranged as a covalent organic framework, wherein the structured organic film may be a multi-segment thick structured organic film.

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Номер записи: 23

30-05-2013 дата публикации

Polycyclo Dyes and Use Thereof

Номер: US20130137873A1

Автор: Narayanan Nara

Принадлежит:

The invention relates to a family of fluorescent compounds that comprise a bridged polycyclo moiety. The compounds can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications, and are particularly useful for the in vivo imaging of regions of interest within a mammal. 1. A fluorochrome compound represented by:{'br': None, 'sup': 1', '2, 'Z—PMB—Z'}wherein{'sup': 1', '2, 'Zand Zeach independently represent a polycyclic group comprising a heterocyclic moiety selected from substituted or unsubstituted indolinium, benzoindolinium, pyrrolopyridinium, benzooxazilinium or benzothiazolinium; and'}PMB represents polymethine bridge comprising a bridged bicyclo-moiety, and salts thereof, wherein the compound has an absorption and emission wavelength in the range from about 600 nm to about 900 nm.2. (canceled)3. (canceled)540-. (canceled) This application claims priority to U.S. Ser. No. 60/889,066 filed Feb. 9, 2007, which is hereby incorporated by reference in its entirety.Optical imaging methods offer a number of advantages over other imaging methods. Such imaging typically uses light in the red and near-infrared (NIR) range (600-1200 nm) to maximize tissue penetration and minimize absorption from natural biological absorbers such as hemoglobin and water. Optical imaging may provide high sensitivity, does not require exposure of test subjects or laboratory personnel to ionizing radiation, can allow for simultaneous use of multiple, distinguishable probes (which may be important in molecular imaging), and offers high temporal and spatial resolution, which is important in functional imaging and in vivo microscopy, respectively.In fluorescence imaging, filtered light or a laser with a defined bandwidth is used as a source of excitation light. The excitation light travels through body tissue, and when the excitation light encounters ...

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Номер записи: 24

20-06-2013 дата публикации

Electrophoretic composition, microcapsule and electrophoretic display device

Номер: US20130155489A1

Автор: Takashi Kato, Yasuhiro Ishiwata

Принадлежит: Fujifilm Corp

Disclosed is an electrophoretic composition including a dye, a non-water-soluble dispersion medium, and charged particles, wherein the dye includes in a molecule thereof at least two color forming moieties including a first color forming moiety and a second color forming moiety, the first color forming moiety having a maximum absorption wavelength that is the shortest maximum absorption wavelength among the at least two color forming moieties, the second color forming moiety having a maximum absorption wavelength that is the longest maximum absorption wavelength among the at least two color forming moieties, a difference between the maximum absorption wavelength of the first color forming moiety and the maximum absorption wavelength of the second color forming moiety being from 50 nm to 400 nm, and the first color forming moiety and the second color forming moiety being bonded through a covalent bond.

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Номер записи: 25

27-06-2013 дата публикации

Di-thiazolyl-benzodiazole based sensitizers and their use in photovoltaic cell

Номер: US20130160854A1

Автор: Abdulrahman M. Al-Ahmari, Ashraful Islam, Md. Akhtaruzzaman, Mohammad Rezaul Karim

Принадлежит: King Abdulaziz City for Science and Technology KACST

Described herein are D-π-A type sensitizers of the formula (I) or (II) having a novel central π-conjugated unit di-thiazolyl-benzodiazole and dye-sensitized electrodes including a substrate having an electrically conductive surface, an oxide semiconductor film formed on the conductive surface, and the above sensitizer of formula (I) or (II), as specified above, supported on the film. A solar cell includes the above electrode, a counter electrode, and an electrolyte deposited there between. The sensitizers of formula (I) and (II) efficiently sensitize the semiconductor materials and show a high solar to electricity conversion efficiency.

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Номер записи: 26

15-08-2013 дата публикации

FLUORESCENT DYES

Номер: US20130209994A1

Автор: LI ZAIGUO, Pande Praveen, PATTON WAYNE FORREST, SZCZEPANIK MACIEJ

Принадлежит: ENZO LIFE SCIENCES, INC.

The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.

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Номер записи: 27

22-08-2013 дата публикации

FLUORESCENT DYES

Номер: US20130217059A1

Автор: LI ZAIGUO, Pande Praveen, PATTON WAYNE FORREST, SZCZEPANIK MACIEJ

Принадлежит: ENZO LIFE SCIENCES, INC.

The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties. 136-. (canceled)44. A method of identifying a specific organelle or region in a cell of interest , the method comprising{'claim-ref': {'@idref': 'CLM-00037', 'claim 37'}, '(a) incubating the cell of interest with the compound of , and'}(b) identifying the location of the organelle or region in the cell of interest by identifying the compound that stains the organelle or region.46. A target molecule comprising the compound of .47. The target molecule of claim 46 , wherein the target molecule is a nucleoside claim 46 , a nucleotide claim 46 , an oligonucleotide claim 46 , a polynucleotide claim 46 , a peptide nucleic acid claim 46 , a protein claim 46 , an oligopeptide claim 46 , an enzyme claim 46 , an antibody claim 46 , a cytokine claim 46 , avidin claim 46 , streptavidin claim 46 , digoxigenin claim 46 , an oligosaccharide claim 46 , a polysaccharide claim 46 , a lipid claim 46 , a liposome claim 46 , a glycolipid claim 46 , or a dye.48. The target molecule of claim 46 , wherein the target molecule is a protein claim 46 , an oligopeptide claim 46 , a nucleotide claim 46 , an oligonucleotide claim 46 , or a polynucleotide.50. The compound of claim 49 , wherein said reactive group comprises a nucleophilic reactive group claim 49 , an electrophilic reactive group claim 49 , a terminal alkene claim 49 , a terminal alkyne claim 49 , a coordinate group or an alkylating agent.51. The compound of ...

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Номер записи: 28

29-08-2013 дата публикации

Photopolymer formulation for producing holographic media having highly crosslinked matrix polymers

Номер: US20130224634A1

Автор: Dennis Hönel, Friedrich-Karl Bruder, Horst Berneth, Marc-Stephan Weiser, Thomas Fäcke, Thomas Rölle

Принадлежит: Bayer Intellectual Property GmbH

The invention relates to a photopolymer formulation comprising a polyol component, a polyisocyanate component, a writing monomer, and a photoinitiator, containing a coinitiator and a dye having the formula F An, where F stands for a cationic dye and An″ stands for an anion, wherein the dye having the formula F An comprises a water absorption of =5%. The invention further relates to a holographic medium, in particular in the form of a film, containing a photopolymer formulation according to the invention, to the use of such a medium for recording holograms, and to a special dye that can be used in the photopolymer formulation according to the invention.

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Номер записи: 29

29-08-2013 дата публикации

Chalcone Structure Fluorescence Dye For Embryonic Stem Cell Probe

Номер: US20130224790A1

Автор: Chang Young-Tae, KANG Nam Young, LEE Sung Chan

Принадлежит:

The invention includes a compound represented by the following structural formula: wherein is described herein. The compounds of the invention are useful in staining embryonic stem cells. 2. The compound of claim 1 , or a salt thereof claim 1 , wherein R is (C-C)alkyl.3. The compound of claim 2 , or a salt thereof claim 2 , wherein R is (C-C)alkyl claim 2 , optionally substituted with one claim 2 , two or three groups independently selected from chloro claim 2 , bromo claim 2 , methyl claim 2 , ethyl claim 2 , methoxy claim 2 , —COOCH claim 2 , —OCOCH claim 2 , cyclopentyl claim 2 , phenyl claim 2 , and phenoxy claim 2 , wherein the phenyl or phenoxy is optionally and independently substituted with one claim 2 , two claim 2 , three claim 2 , four claim 2 , or five groups independently selected from fluoro claim 2 , chloro claim 2 , and methoxy.5. The compound of claim 1 , or a salt thereof claim 1 , wherein R is (C-C)alkenyl.6. The compound of claim 5 , or a salt thereof claim 5 , wherein R is —CH═CH claim 5 , —CHCHC═CH claim 5 , (CH)C═CH claim 5 , optionally substituted with one or more substituents selected from methyl and phenyl claim 5 , wherein the phenyl is optionally substituted with chloro.8. The compound of claim 1 , or a salt thereof claim 1 , wherein R is carbocyclyl.9. The compound of claim 8 , or a salt thereof claim 8 , wherein R is an optionally substituted aryl.10. The compound of claim 9 , or a salt thereof claim 9 , wherein R is an optionally substituted phenyl.11. The compound of claim 10 , or a salt thereof claim 10 , wherein R is phenyl claim 10 , optionally substituted with one claim 10 , two claim 10 , three claim 10 , four or five groups independently selected from halo claim 10 , NO claim 10 , —NHCO(C-C)alkyl claim 10 , —OCO(C-C)alkyl claim 10 , (C-C)alkyl claim 10 , halo(C-C)alkyl claim 10 , (C-C)alkoxy claim 10 , and phenyl.12. The compound of claim 11 , or a salt thereof claim 11 , wherein R is phenyl claim 11 , optionally substituted ...

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Номер записи: 30

05-09-2013 дата публикации

Cyanine compounds

Номер: US20130230466A1

Автор: Boguslawa R. Dworecki, Frank G. Lehmann, Greg Hermanson, Marie Christine Nlend, Matthias S. Wenzel, Peter T. Czerney, Surbhi Desai

Принадлежит: Individual

Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

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Номер записи: 31

03-10-2013 дата публикации

Disperse Azo Dyes

Номер: US20130255011A1

Автор: Lauk Urs, Nowack Patric, Tzikas Athanassios

Принадлежит: Huntsman International LLC

The present invention relates to disperse azo dyes based on diazo components having at least one fluorine-containing substituent and an 2,6-diaminosubstituted pyridine coupling component, to a process for the preparation of such dyes and to their use in the dyeing or printing of semi-synthetic and, especially, synthetic hydrophobic fibre materials, more especially textile materials. 2. A dye of formula (1) according to claim 1 , wherein Ris fluoro or trifluoromethyl.3. A dye of formula (1) according to claim 1 , wherein Rand Rdenote hydrogen claim 1 , fluoro claim 1 , chloro claim 1 , bromo claim 1 , cyano or nitro.4. A dye of formula (1) according to claim 1 , wherein Rand Rdenote hydrogen or phenyl substituted with trifluoromethyl claim 1 , n-propyl claim 1 , n-butyl or n-butoxy.6. A dye of formula (1a) according to claim 5 , wherein Rand Rare hydrogen or phenyl.8. A dye mixture comprising at least two structurally different azo dyes of formula (1) according to .9. A process for the dyeing or printing of a semi-synthetic or synthetic hydrophobic fibre material claim 1 , wherein a dye of formula (1) according to is applied to the said material or is incorporated into that material.10. (canceled)11. A process for the dyeing or printing of a semi-synthetic or synthetic hydrophobic fibre material claim 8 , wherein a dye mixture according to is applied to the said material or is incorporated into that material. The present invention relates to disperse dyes based on diazo components having at least one fluorine-containing substituent, to a process for the preparation of such dyes and to their use in the dyeing or printing of semi-synthetic and, especially, synthetic hydrophobic fibre materials, more especially textile materials.Disperse azo dyes having an aniline diazo component and an 2,6-diaminosubstituted pyridine coupling component have been known for a long time and are used in the dyeing of hydrophobic fibre materials. It has been found, however, that the dyeings ...

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Номер записи: 32

10-10-2013 дата публикации

Foamable fluoropolymer compositions

Номер: US20130267618A1

Автор: Besana Giambattista, Bragante Letanzio, Brinati Giulio, Colaianna Pasqua, Di Nicolo Emanuele, Marchionni Giuseppe

Принадлежит: SOLVAY SPECIALTY POLYMERS ITALY S.P.A.

The invention pertains to foamable thermoplastic fluoropolymer composition comprising: 3. The foamable thermoplastic fluoropolymer composition of claim 2 , wherein perfluoroalkoxysulphonic derivative is selected from the group consisting of the following compounds: CF—CF—OCFCF—SOK claim 2 , CF—CF—OCFCF—SONa claim 2 , CF—CF—OCFCF—SONH claim 2 , (CF—CF—OCFCF—SO)Ba claim 2 , (CF—CF—OCFCF—SO)Ca claim 2 , CF—OCFCF—OCFCF—SOK claim 2 , CF—OCFCF—OCFCF—SONa claim 2 , CF—OCFCF—OCFCF—SONH claim 2 , (CF—OCFCF—OCFCF—SO)Ba claim 2 , (CF—CFCF—OCFCF—SO)Ca claim 2 , CFCF—OCFCF(CF)—OCFCF—SOK claim 2 , CFCF—OCFCF(CF)—OCFCF—SONa claim 2 , CFCF—OCFCF(CF)—OCFCF—SONH claim 2 , (CFCF—OCFCF(CF)—OCFCF—SO)Ba and (CFCF—OCFCF(CF)—OCFCF—SO)Ca.4. The foamable thermoplastic fluoropolymer composition according to wherein the perfluoroalkoxysulphonic derivative from 1 to about 3 000 ppm claim 1 , by weight based on the total weight of the composition.6. The foamable thermoplastic fluoropolymer composition according to claim 5 , wherein said polymer (A) is a per(halo)fluoropolymer substantially free from hydrogen atoms.8. The foamable thermoplastic fluoropolymer composition according to claim 7 , wherein said polymer (A) is a TFE copolymer comprising recurring units derived from at least one per(halo)fluoromonomer (PFM) selected from the group consisting of:{'sub': 2', 'f1', 'f1', '1', '6, '1. per(halo)fluoroalkylvinylethers complying with general formula CF═CFORwherein Ris a C-Cper(halo)fluoroalkyl;'}{'sub': 2', '01', '01', '1', '12, '2. per(halo)fluoro-oxyalkylvinylethers complying with general formula CF═CFOX, wherein Xis a C-Cper(halo)fluorooxyalkyl having one or more ether groups;'}{'sub': 3', '8, '3. C-Cperfluoroolefins; and'}4. mixtures thereof9. The foamable thermoplastic fluoropolymer composition according to claim 8 , wherein said polymer (A) is selected from the group consisting of TFE copolymers consisting essentially of recurring units derived from tetrafluoroethylene (TFE) and ...

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Номер записи: 33

17-10-2013 дата публикации

COMPOSITIONS AND ARTICLES OF MANUFACTURE CONTAINING SILOXANE

Номер: US20130274391A1

Автор: An Narong, Niu Yaming, Ren Yu, Shen Dake

Принадлежит: SABIC INNOVATIVE PLASTICS IP B.V.

Compositions containing a polycarbonate and a linear and cyclic phenyl containing siloxanes are disclosed. Specifically, a composition comprising: (a) a branched polycarbonate resin, (b) a flame retardant, (c) at least one linear phenyl containing siloxane and at least one cyclic phenyl containing siloxane, and (d) a linear polycarbonate resin when said branched polycarbonate is less than 100% based upon weight percent of total polycarbonate in said composition, wherein the amounts of said branched and linear polycarbonate resins, said linear siloxanes and cyclic siloxanes, and flame retardant are in amounts effective to provide a molded article from said composition with a UL94 V0 p(FTP) value of 0.90 or greater at a thickness of between 1 mm and 2.5 mm or at 2.5 mm or at 1.5 mm or at 1 mm is disclosed. In addition, a composition comprising: (a) a linear polycarbonate resin, (b) a flame retardant, (c) at least one phenyl-containing linear siloxane and at least one phenyl-containing cyclic siloxane, wherein the amounts of said linear polycarbonate resins, said phenyl-containing linear siloxanes and said phenyl-containing cyclic siloxanes, and said flame retardant are in amounts effective to provide a molded article of said composition with a UL94 V0 p(FTP) value of 0.90 or greater at a thickness of between 1 mm and 2.5 mm or at 2.5 mm or at 1.5 mm or at 1 mm is disclosed. 1. A composition comprising: (a) a branched polycarbonate resin , (b) a flame retardant , (c) at least one linear phenyl containing siloxane and at least one cyclic phenyl containing siloxane , and (d) a linear polycarbonate resin when said branched polycarbonate is less than 100% based upon weight percent of total polycarbonate in said composition , wherein the amounts of said branched and linear polycarbonate resins , said linear siloxanes and cyclic siloxanes , and flame retardant are in amounts effective to provide a molded article from said composition with a UL94 V0 p(FTP) value of 0.90 or ...

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Номер записи: 34

17-10-2013 дата публикации

Cyanine dyes and their conjugates

Номер: US20130274452A1

Автор: Daniel R. Draney, Lael Cheung, Xinshe Xu

Принадлежит: Li Cor Inc

Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.

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Номер записи: 35

31-10-2013 дата публикации

POLYCARBOXYLIC ACID DYE WITH LOW POLYMERIZATION DEGREE

Номер: US20130289218A1

Автор: Ma Wei, Tang Bingtao, Zhang Shufen

Принадлежит: Dalian University of Technology

The present invention provides a polycarboxylic acid dye with low polymerization degree, which is formed by using a macromolecule skeleton of polymaleic acid linked to an azo chromophore, an azo-metal complexation chromophore or an anthraquinone chromophore via a bridge group of amide or ester bond. The dye is useful for dyeing and printing leather, protein fiber, cellulose fiber and synthetic fiber. The present invention relates to a polycarboxylic acid dye with low polymerization degree.The polymerization-type dye has high strength, good film-formability, solvent resistance and processability, and has excellent transference resistance and moisture resistance, which thus represents a new field within the macromolecule and dye chemistry. The polymerization-type dye of polycarboxylic acid has carboxyl group supported on the molecule, which can not only endue the dye water-solubility, so as to be useful for coloring the natural fiber and leather; but also change into hydrophobic dye owing to the ability of the carboxyl group to be removed or be amidated or esterified under certain conditions, so as to color the synthetic fiber. The polycarboxylic acid dye hereby is broadly applicable, and thus is much applicably valuable and has great prospect.Lewis et al. produce a tetra-carboxylic acid dye by reacting an aspartic acid and a dye of C.I. reactive red 120 with di-active groups, which dye is baked at a temperature of 180-210° C. for 1-2.5 minutes, reacted with fiber via a transition state of acid anhydride for dyeing. However, the dye has low dye fixation, and the temperature for dyeing is relatively high (Lewis, AATCC, 1995, 536-544). U.S. Pat. No. 3,911,164 and U.S. Pat. No. 6,764,541 disclose to polymerize the maleic anhydride and methylvinyl ether to obtain a copolymerized polymer, which is then reacted with a dye, so as to obtain a carboxyl-comprising copolymerized macromolecule dye; whilst the incorporation of copolymerized group decreases the content of acid ...

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Номер записи: 36

07-11-2013 дата публикации

Novel compound, dye and colored photosensitive composition

Номер: US20130296455A1

Автор: Koichi Shigeno, Masaaki Shimizu, Yosuke Maeda

Принадлежит: Adeka Corp

Disclosed are a dye that is excellent in solubility and heat-resistance, and a novel compound that is suitable for the dye, and specifically provides a yellow dye having a maximum absorption wavelength in the region of 420 to 470 nm. Also disclosed are a colored (alkali-developable) photosensitive composition and an optical filter using the dye, and specifically provides a color filter that does not decrease luminance and thus is preferable for an image display device such as a liquid crystal display panel. Specifically, disclosed are a novel compound represented by the following general formula (1), a dye using the compound, and a colored (alkali-developable) photosensitive composition and a color filter. The content of the above-mentioned general formula (1) is as described in the description.

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Номер записи: 37

14-11-2013 дата публикации

Photoelectric conversion device, photoelectric conversion device material, photosensor and imaging device

Номер: US20130299799A1

Автор: Katsuyuki Yofu, Kimiatsu Nomura, Mitsumasa Hamano, Tetsuro Mitsui

Принадлежит: Fujifilm Corp

A photoelectric conversion device comprising an electrically conductive film, an organic photoelectric conversion film, and a transparent electrically conductive film, wherein the organic photoelectric conversion film contains a compound represented by the following formula (1) and an n-type organic semiconductor: wherein each of R 1 and R 2 independently represents a substituted aryl group, an unsubstituted aryl group, a substituted heteroaryl group or an unsubstituted heteroaryl group, each of R 3 to R 11 independently represents a hydrogen atom or a substituent provided that an acidic group is excluded, m represents 0 or 1, n represents an integer of 0 or more, R 1 and R 2 , R 3 and R 4 , R 3 and R 5 , R 5 and R 6 , R 6 and R 8 , R 7 and R 8 , R 7 and R 9 , or R 10 and R 11 may be combined each other to form a ring, and when n is an integer of 2 or more, out of a plurality of R 7 's and R 8 's, a pair of R 7 's, a pair of R 8 's, or a pair of R 7 and R 8 may be combined each other to form a ring.

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Номер записи: 38

12-12-2013 дата публикации

Fluorinated voltage sensitive dyes, preparation thereof, and optical methods of use

Номер: US20130330762A1

Автор: Corey D. Acker, Leslie M. Loew, Ping Yan

Принадлежит: University of Connecticut

A fluorinated voltage sensitive dye has the structure wherein p is 0, 1, or 2; X q− is an anionic counterion having a charge, q, that is 1 or 2; n is 1 or 2; R 1 is an optionally substituted C 1 -C 12 , alkyl; R 2 is hydrogen, and R 3 is hydrogen or fluorine; or R 2 and R 3 collectively form a divalent —CH═CH—CH═CH— group; R 4 and each occurrence of R 5 are each independently hydrogen or fluorine; R 6 is hydrogen or fluorine or trifluoromethyl; and each occurrence of R 7 is independently C 1 -C 6 alkyl; provided that the dye comprises at least one fluorine atom. The dye is particularly useful for monitoring the dynamics of action potentials in axons and/or dendrites.

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Номер записи: 39

26-12-2013 дата публикации

Colorant compound derived from genipa americana genipin and glycine

Номер: US20130345427A1

Автор: Esteban Vargas, Juan Fernando Gil, Luis Fernando Echeverry

Принадлежит: ECOFLORA SA, ECOFLORA Sas

The present invention provides colorant compounds and its molecular structural formulas and methods of isolation of the colorant compounds derived from a reaction of Genipa americana genipin and glycine. The novel compounds were obtained from multiple fractioning by chromatography of the reaction resulting material. The molecular structural formulas resulted from 1 H nuclear magnetic resonance spectroscopy, J-Modulation, H—H Correlation Spectroscopy experiments, and other molecular structural tools analysis.

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Номер записи: 40

02-01-2014 дата публикации

NOVEL COMPOUND HAVING alpha-CYANOACRYLATE STRUCTURE, DYE, AND COLORED PHOTOSENSITIVE COMPOSITION

Номер: US20140005292A1

Автор: Koich Shigeno, Masaaki Shimizu, Yosuke Maeda

Принадлежит: Adeka Corp

A compound represented by the following general formula (1). In the formula, A represents a benzene ring, a naphthalene ring and the like, wherein these rings may be substituted with a halogen atom and the like, R 1 represents a hydrogen atom and the like, R 2 represents a C 1-35 hydrocarbon group having or not having at least one group selected from an epoxy group, 4-vinylphenyl group and a (meth)acryloyloxy group, or a hydrogen atom, wherein at least one of R 2 with n occurrences is a C 3-35 hydrocarbon group having at least one group selected from an epoxy group, a 4-vinylphenyl group and a (meth)acryloyloxy group, n represents an integer of 1 to 6, and X represents a nitrogen atom, an oxygen atom, a sulfur atom, a phosphorus atom, or an n-valent organic group having 35 or less carbon atoms.

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Номер записи: 41

13-03-2014 дата публикации

Methods of Using Dyes in Association with Nucleic Acid Staining or Detection and Associated Technology

Номер: US20140073058A1

Автор: Fei Mao, Wai-Yee Leung

Принадлежит: Biotium Inc

Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids.

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Номер записи: 42

03-04-2014 дата публикации

Polyamide moulding compounds and use thereof in the production of moulded articles

Номер: US20140094548A1

Автор: HOFFMANN Botho, LAMBERTS Nikolai, ROTH Mark D.

Принадлежит: EMS-PATENT AG

The present invention relates to polyamide moulding compounds, pigmented black, which include nigrosin and at least one nucleation agent, carbon black being ruled out. The present invention likewise relates to a method for producing moulded articles from the mentioned polyamide moulding compounds and also the corresponding moulded articles. The polyamide moulding compounds are used in the production of components with increased temperature requirements, e.g. in the automobile sector. 1. A polyamide moulding compound having the following composition:(a) 20 to 99% by weight of at least one polyamide,(b) 0.05 to 5% by weight of nigrosin,(c) 0.005 to 2% by weight of at least one nucleation agent,(d) 0 to 79.945% by weight of at least one additive or supplement,wherein components (a) to (d) add up in total to 100% by weight of the polyamide moulding compound and carbon black is not a component of the polyamide moulding compound.2. The polyamide moulding compound according to claim 1 ,wherein polyamide (a) is selected from the group consisting of PA 6; PA 4.6; PA 6.6; PA 6.6/6; PA 6.10; PA 6.12; PA 10.10; PA 11; PA 12; PA MXD.6; PA MXD.10; PA MACM.12; PA PACM.12; PA 6.T/6.I; PA 6.T/6.6; PA 6.T/6.12; PA 6.T/10.12; PA 4.T; PA 9.T; PA 10.T; PA 12.T; PA 10/6.T; PA 6.T/6.I/6.6; PA 11/10.T; PA 12/10.T; PA 6.10/10.T; PA 6.12/10T; PA 10.10/10T; PA 10.12/10.T; PA 12.12/10T; PA 11/10.T/12; PA 11/10.T/6; PA 12/10.T/6; PA 11/10.T/10.I; PA 11/10.T/10.6; PA 12/10.T/10.I; PA 12/10.T/10.6; PA 6.T/MPMD.T; polyamides, the diamine component of which is PACM, MACM, CHDA or TMDC and/or mixtures or blends thereof.3. The polyamide moulding compound according to claim 1 ,wherein polyamide (a) is a blend of PA 6 and PA 66 or of PA 6 and polyphthalamide.4. The polyamide moulding compound according to claim 1 ,wherein polyamide (a) comprises 0.4 to 16% by weight of PA 6.5. The polyamide moulding compound according to claim 1 ,wherein the at least one nucleation agent (c) is selected from the group ...

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Номер записи: 43

05-01-2017 дата публикации

COLORING COMPOUND AND TONER

Номер: US20170001992A1

Автор: Kitao Akiko

Принадлежит:

This invention aims at providing a compound capable of providing a toner having high covering power and a toner having high covering power, which is achieved by an azamethine acetyl amide-based compound having a specific structure. 4. A toner comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a binder resin and the compound according to .'} Field of the InventionThe present invention relates to a coloring compound and a toner.Description of the Related ArtUnder present circumstances, a color reproduction area in an image formed. by a color toner of each color of yellow, magenta, and cyan cannot completely cover a color reproduction area on a computer display screen. The technical barrier is caused by a difference in the principles that, while the computer display screen is visually recognized by an additive color process using transmitted light, an image formed by an electrophotography using color toners is visually recognized by a subtractive color process using reflected light. In recent years, in order to further improve the monitor color reproducibility, an example of using dyes with high color saturation and a high lightness value as coloring materials for color toners has been reported.Japanese Patent Laid-Open. Nos. 2009-080478 and 5-034980 have report a toner containing a xanthene dye and German Patent Laid-Open No. 4,217,973, Specification and Japanese Patent Laid-Open No. 2003-195570 have report a toner containing a methine dye. In general, a dye-based colorant, has excellent transparency, and therefore a certain amount of coloring materials is required in order to increase covering power. However, the increase in the coloring material amount deteriorates the transparency and the color development properties intrinsic to dyes. Therefore, it has been required to develop dyes having high absorbance of chromophores per g.The present invention provides a toner having high covering power.The above-described purpose can be achieved by the use of the ...

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Номер записи: 44

04-01-2018 дата публикации

BENZOPYRYLIUM COMPOUNDS

Номер: US20180002340A1

Автор: Czerney Peter T., Desai Surbhi, Hermanson Greg, Lehmann Frank G., Nlend Marie Christine, Wenzel Matthias S.

Принадлежит:

Compounds used as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided. 2. The compound of wherein{'sup': 2', '3', '5', '6', '11', '13', '14', '1', '4', '7', '8', '9', '12, 'when the compound is according to general formula Ia or IIa each of Rand Ris independently selected from sulfoalkyl or a PEG group P-L-Z; Ris alkyl; Ris t-butyl or an unsubstituted or substituted phenyl; Ris sulfonic acid, carboxylic acid, or an amino group; each of Rand Ris independently selected from alkyl, sulfoalkyl, or a PEG group P-L-Z; and each of R, R, R, R, R, and Ris H;'}{'sup': 2', '3', '5', '6', '11', '13', '14', '1', '4', '7', '8', '9', '12, 'when the compound is according to general formula Ib or IIb each of Rand Ris independently selected from sulfoalkyl or a PEG croup P-L-Z; Ris alkyl; Ris t-butyl or an unsubstituted or substituted phenyl; Ris sulfonic acid, carboxylic acid, or an amino group; each of Rand Ris independently selected from alkyl, sulfoalkyl, or a PEG group P-L-Z; and each of R, R, R, R, R, and Ris H;'}{'sup': 2', '3', '5', '6', '11', '13', '14', '1', '4', '7', '8', '9', '12, 'when the compound is according to general formula Ic or IIc each of Rand Ris independently selected from sulfoalkyl or a PEG group P-L-Z; Ris alkyl; Ris t-butyl or an unsubstituted or substituted phenyl; Ris sulfonic acid, carboxylic acid, or an amino group; each of Rand Ris independently selected from alkyl, sulfoalkyl, or a PEG group P-L-Z; and each of R, R, R, R, R, and Ris H; and'}{'sup': 2', '3', '5', '6', '11', '13', '14', '1', '4', '7', '8', '9', '12, 'when the compound is according to general formula Id or IId each of Rand Ris independently selected from sulfoalkyl or a PEG group P-L-Z; Ris alkyl; Ris t-butyl or an unsubstituted or substituted phenyl ...

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Номер записи: 45

07-01-2021 дата публикации

TRIAZABUTADIENES AS CLEAVABLE CROSS-LINKERS

Номер: US20210002234A1

Автор: Cornali Brandon M., Guzman Lindsay E., Jewett John C., Kimani Flora W.

Принадлежит:

Triazabutadiene molecules as cleavable cross-linkers adapted to cross-link components with click chemistry, e.g., clickable triazabutadienes. For example, in some embodiments, the triazabutadienes feature alkyne handles attached to the imidazole portion or the aryl portion of the triazabutadienes, wherein the alkyne handles can link to azide handles (e.g., azide handles disposed on other components) via click chemistry. Also described are methods of producing said clickable triazabutadienes and methods of use of said clickable triazabutadienes. The present invention also features methods of cleaving said clickable triazabutadienes, e.g., for liberating the diazonium species for further chemical reactions. 120-. (canceled)22. The clickable triazabutadiene of claim 21 , wherein the tri-substituted aryl group comprises mesityl claim 21 , a NHS-ester moiety; an oligonucleotide; a peptide; a fluorescence quencher; a pro-fluorophore; an alkyne; a triazene; an aldehyde; an amine; an aminooxy; a halogen; or a combination thereof.23. The clickable triazabutadiene of claim 21 , wherein the triazabutadiene comprises is linked to a peptide claim 21 , an oligonucleotide claim 21 , or a drug.24. The clickable triazabutadiene of claim 21 , wherein the linking component comprises a peptide claim 21 , an oligonucleotide claim 21 , or a drug.26. The clickable triazabutadiene of claim 25 , wherein the tri-substituted aryl group comprises mesityl claim 25 , a NHS-ester moiety; an oligonucleotide; a peptide; a fluorescence quencher; a pro-fluorophore; an alkyne; a triazene; an aldehyde; an amine; an aminooxy; a halogen; or a combination thereof.27. The clickable triazabutadiene of claim 25 , wherein the triazabutadiene comprises is linked to a peptide claim 25 , an oligonucleotide claim 25 , or a drug.28. The clickable triazabutadiene of claim 25 , wherein the linking component comprises a peptide claim 25 , an oligonucleotide claim 25 , or a drug. Triazabutadienes can be triggered to ...

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Номер записи: 46

07-01-2021 дата публикации

Azo Compound and Black Dye Composition Including the Same

Номер: US20210002486A1

Автор: Cheng-Hua Lee, Long-Li Lai, Yao-Chih LU

Принадлежит: National Chi Nan Univ

Disclosed is an azo compound represented by Formula (I) in which R 1 is hydrogen or methyl, R 2 is hydrogen or methyl, and R 3 is hydrogen, an unsubstituted linear alkyl group of from 1 to 4 carbon atoms, or an unsubstituted branched alkyl group of from 1 to 9 carbon atoms. This disclosure also provides a black dye composition including the azo compound represented by Formula (I).

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Номер записи: 47

05-01-2017 дата публикации

Electrowetting element

Номер: US20170003497A1

Автор: Jurriën Mans, Muhammad Arief Adityaputra, Robin Leguijt, Romaric Mathieu Massard

Принадлежит: Amazon Technologies Inc, Liquavista BV

Electrowetting element including a compound comprising a plurality of colorant moieties and a linker. The plurality of colorant moieties includes a first colorant moiety having a first net dipole and a second colorant moiety having a second net dipole. The plurality of colorant moieties are linked by and disposed around the linker so that the first net dipole and the second net dipole at least partially cancel each other.

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Номер записи: 48

01-01-2015 дата публикации

AZO COMPOUND, PIGMENT DISPERSANT CONTAINING THE AZO COMPOUND, PIGMENT COMPOSITION, PIGMENT DISPERSION AND TONER

Номер: US20150004538A1

Автор: Hasegawa Waka, Hasegawa Yuki, Hirose Masashi, Kawamura Masashi, Mashida Ayano, Murai Yasuaki, Nishiura Chiaki, Seki Masanori, Toyoda Takayuki, Watanabe Taiki

Принадлежит:

An object of the present invention is to provide an azo compound capable of improving the dispersibility of an azo pigment in a non-water-soluble solvent. The object of the present invention is achieved with an azo compound wherein a coloring matter moiety having a diketone azo structure and a polymer are bonded to each other. 2. The azo compound according to claim 1 , wherein Rand Rin the formula (1) are the same substituents.3. The azo compound according to claim 1 , wherein the linking group in the formula (1) comprises any one linkage selected from the group consisting of an amide linkage claim 1 , an ester linkage and an ether linkage.4. The azo compound according to claim 1 , wherein the linking group in the formula (1) comprises a carboxylic acid amide linkage.5. A pigment dispersant comprising the azo compound according to .6. A pigment composition comprising the pigment dispersant according to and an azo pigment.7. The pigment composition according to claim 6 , wherein the azo pigment is an acetoacetanilide pigment.9. A pigment dispersion comprising the pigment composition according to and a non-water-soluble solvent.10. The pigment dispersion according to claim 9 , wherein the non-water-soluble solvent is a styrene monomer.11. A toner comprising toner particles containing a binder resin claim 1 , a colorant and a wax component claim 1 , wherein the colorant contains the azo compound according to .12. The toner according to claim 11 , wherein the toner particles are produced in an aqueous medium.13. The toner according to claim 11 , wherein the toner particles are produced by using a suspension polymerization method or a suspension granulation method. The present invention relates to a novel azo compound, a pigment dispersant containing the azo compound, a pigment composition, a pigment dispersion and a toner using the pigment composition as a colorant.A fine pigment has a tendency to be strong in the aggregation force between the pigment particles in a ...

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Номер записи: 49

02-01-2020 дата публикации

Color vision correction filter and optical component

Номер: US20200004051A1

Автор: Hideki Wada, Kazuyuki Yamae, Tomoya Iwahashi

Принадлежит: Panasonic Intellectual Property Management Co Ltd

A color vision correction filter includes a least one type of dye material and the lowest value of transmittance of the color vision correction filter in a wavelength band ranging from 440 nm to 600 nm, inclusive, is in the range of plus or minus 50 nm of 535 nm.

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Номер записи: 50

14-01-2021 дата публикации

TARGETED PHOTOACOUSTIC AGENTS AND USES THEREOF

Номер: US20210008229A1

Автор: Naperstkow Zoya, Slikboer Samantha, Valliant John

Принадлежит:

The present application relates to photoacoustic agents, to kits comprising such photoacoustic agents and to uses thereof such as in methods for detecting a presence of a target in a subject. The photoacoustic agents comprise a photoacoustically active moiety (for example, a near infrared dye) that is coupled to a first bioorthogonal reactive group and optionally a targeting entity for a target that is coupled to a second bioorthogonal reactive group. 1. A photoacoustic agent comprising a photoacoustically active moiety coupled to a first bioorthogonal reactive group.2. The photoacoustic agent of claim 1 , wherein the photoacoustically active moiety is selected from a gold nanoparticle claim 1 , a carbon nanomaterial claim 1 , a polymer nanoparticle claim 1 , a genetically encoded chromophore and a near infrared (NIR) dye.3. The photoacoustic agent of claim 2 , wherein the photoacoustically active moiety is a NIR dye.4. The photoacoustic agent of claim 3 , wherein the NIR dye is capable of binding a blood protein.7. The photoacoustic agent of claim 1 , wherein the photoacoustic agent further comprises a targeting entity for a target.8. The photoacoustic agent of claim 7 , wherein the targeting entity is coupled to a second bioorthogonal reactive group that is complementary to the first bioorthogonal reactive group and the first bioorthogonal reactive group and the second bioorthogonal reactive group form a bioorthogonal complex.9. The photoacoustic agent of claim 8 , wherein the first bioorthogonal reactive group and the second bioorthogonal reactive group claim 8 , in either order claim 8 , are inverse electron demand Diels Alder reaction pairs claim 8 , or an azide and a functionalized phosphine claim 8 , or an azide and a strained alkyne.10. The photoacoustic agent of claim 9 , wherein the first bioorthogonal reactive group and the second bioorthogonal reactive group claim 9 , in either order claim 9 , are tetrazine and transcyclooctene.11. The photoacoustic ...

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Номер записи: 51

27-01-2022 дата публикации

PROTEIN MELT ANALYSIS USING DIPYRROMETHENEBORON DIFLUORIDE COMPOUNDS

Номер: US20220026437A1

Автор: Egry Levente, Gee Kyle

Принадлежит:

According to the present teachings, systems, compositions, kits and methods for protein melt analysis are provided that utilizing a dye that is a dipyrrometheneboron difluoride compound. In some embodiments, a method comprises preparing a sample by mixing at least one protein with a dye, and applying a controlled heating, while recording the fluorescence emission of the sample. 2. The method of claim 1 , wherein the dye in the protein-dye mixture is 4 claim 1 ,4-difluoro-1 claim 1 ,3 claim 1 ,5 claim 1 ,7-tetramethyl-8-(4-maleimidylphenyl)-4-bora-3a claim 1 ,4a-diaza-s-indacene.3. The method of claim 1 , wherein the dye in the protein-dye mixture is 4 claim 1 ,4-difluoro-3 claim 1 ,5-bis(4-methoxyphenyl)-8-(4-maleimidylphenyl)-4-bora-3a claim 1 ,4a-diaza-s-indacene.4. The method of claim 1 , wherein the controlled heating is a thermal ramp.5. The method of claim 4 , wherein the thermal ramp is between about 20° C. to about 95° C.6. The method of claim 1 , wherein the controlled heating is isothermal heating.7. The method of claim 1 , wherein the sample solution mixture further comprises a buffer.8. The method of claim 1 , wherein the sample solution mixture further comprises a surfactant.9. The method of claim 8 , wherein the surfactant is at or above the critical micelle concentration.10. The method of claim 1 , wherein the sample solution mixture further comprises a polyol.11. The method of claim 10 , wherein the polyol is glycerol.12. The method of claim 10 , wherein the polyol is a polysaccharide. This application is a continuation of U.S. application Ser. No. 16/516,545 filed Jul. 19, 2019, which is a continuation of U.S. application Ser. No. 15/392,295 filed Dec. 28, 2016, which is a divisional of U.S. application Ser. No. 13/751,030 filed Jan. 25, 2013, now, U.S. Pat. No. 9,568,478, which claims a priority benefit under 35 U.S.C. § 119(e) to U.S. Provisional Application No. 61/591,383 filed Jan. 27, 2012, the contents of which are incorporated herein by ...

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Номер записи: 52

11-01-2018 дата публикации

Method of Synthesizing Near IR, Closed Chain Sulfo-Cyanine Dyes

Номер: US20180009987A1

Автор: Koilpillai Jesudoss, Ramesh Veerappan, Ratheshkumar Periyadurai, Sekar Kulandai raj Antony, Sorger Jonathan

Принадлежит: INTUITIVE SURGICAL OPERATIONS, INC.

Compositions and methods of synthesizing near IR, closed chain, sulfo-cyanine dyes are provided. 2. The method of claim 1 , wherein the base is a non-nucleophilic base.3. The method of claim 2 , wherein the non-nucleophilic base is selected from the group consisting triethylamine claim 2 , di-isopropyl ethyl amine claim 2 , quinuclidine claim 2 , pyridine claim 2 , sodium acetate claim 2 , sodium carbonate claim 2 , potassium carbonate and cesium carbonate.4. The method of claim 1 , wherein solvent comprises acetic acid and acetonitrile.5. The method of claim 1 , wherein the inert atmosphere is Argon.6. The method of claim 1 , wherein{'sup': 1', '1a, 'sub': 1-6', '3, 'Rand Rare each independently Calkylene-SOH;'}{'sup': 2', '2a', '3, 'sub': '1-6', 'R, R, and Rare each Calkyl;'}{'sup': '1a', 'sub': '1-6', 'Ris Calkylene-COOH; and'}each subscript n is 0.8. The method of claim 1 , wherein the compound of Formula V is prepared by a non-nucleophilic base.10. The method of claim 9 , wherein the base is a non-nucleophilic base.11. The method of claim 10 , wherein the non-nucleophilic base is selected from the group consisting triethylamine claim 10 , di-isopropyl ethyl amine claim 10 , quinuclidine claim 10 , pyridine claim 10 , sodium acetate claim 10 , sodium carbonate claim 10 , potassium carbonate and cesium carbonate.12. The method of claim 9 , wherein solvent comprises dimethylformamide.13. The method of claim 9 , wherein{'sup': 1', '1a, 'sub': 1-6', '3, 'Rand Rare each independently Calkylene-SOH;'}{'sup': 2', '2a', '3, 'sub': '1-6', 'R, R, and Rare each Calkyl;'}{'sup': '3a', 'sub': '1-6', 'Ris Calkylene-COOH; and'}{'sup': '5', 'sub': '3', 'Ris SOH.'}14. The method of claim 9 , wherein the compound of Formula VII is prepared in an amount of at least about 1 g.19. The method of claim 18 , wherein the solvent is selected from the group consisting of water claim 18 , methanol claim 18 , ethanol claim 18 , isopropanol claim 18 , diethyl ether claim 18 , tetrahydrofuran ...

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Номер записи: 53

08-01-2015 дата публикации

DYE COMPOSITIONS, METHODS OF PREPARATION, CONJUGATES THEREOF, AND METHODS OF USE

Номер: US20150011731A1

Автор: Altman Roger, Blanchard Scott C., WARREN J. David, Zhou Zhou

Принадлежит: CORNELL UNIVERSITY

Dye compounds of the formula (1) wherein A is a protective agent group that has a characteristic of modifying the singlet-triplet occupancy of the shown cyanine moiety, and M is a reactive crosslinking group or a group that can be converted to a reactive crosslinking group. Methods for synthesizing the dye compounds and applications for their use are also described. 2. The compound of claim 1 , wherein at least one of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris a hydrophilic group or a hydrocarbon group substituted with at least one hydrophilic group.3. The compound of claim 1 , wherein A is comprised of a nitro-substituted aryl group claim 1 , benzopyran group claim 1 , cyclic polyene group claim 1 , or derivative thereof.4. The compound of claim 1 , wherein M is comprised of a COOR′ group claim 1 , maleimide group claim 1 , azide group claim 1 , or guanine group bound by its 6-oxygen atom claim 1 , wherein R′ is H claim 1 , a hydrocarbon group having 1 to 6 carbon atoms claim 1 , or an activated organoester group.5. The compound of claim 1 , wherein m is an integer of 1 to 6.6. The compound of claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , and Rare methyl groups.9. The method of claim 7 , wherein at least one of R claim 7 , R claim 7 , R claim 7 , R claim 7 , R claim 7 , R claim 7 , R claim 7 , R claim 7 , R claim 7 , R claim 7 , R claim 7 , and Ris a hydrophilic group claim 7 , or a hydrocarbon group substituted with at least one hydrophilic group.10. The method of claim 7 , wherein A is comprised of a nitro-substituted aryl group claim 7 , benzopyran group claim 7 , cyclic polyene group claim 7 , or derivative thereof.11. The method of claim 7 , wherein M is comprised of a COOR′ group claim 7 , maleimide group claim 7 , azide group claim 7 , or guanine group bound by its 6-oxygen atom claim 7 , wherein R′ is H claim 7 , a hydrocarbon group having 1 to 6 carbon ...

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Номер записи: 54

14-01-2021 дата публикации

Dyes for analysis of protein aggregation

Номер: US20210009809A1

Автор: Anatoliy Balanda, Anthony Ludlam, Dee Shen, Jack Coleman, Kateryna Volkova, Lijun Dai, Mykhaylo Losytskyy, Praveen Pande, Sergiy M. Yarmoluk, Vladyslava Kovalska, Wayne Forrest Patton

Принадлежит: Enzo Life Sciences Inc

Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.

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Номер записи: 55

14-01-2016 дата публикации

ORGANIC DYE FOR A DYE SENSITIZED SOLAR CELL

Номер: US20160012976A1

Автор: ABBOTTO Alessandro, BIAGINI Paolo, MANFREDI Norberto

Принадлежит: ENI S.P.A.

Organic dye for a dye sensitized solar cell (DSSC) comprising at least one substituted pyrrole group. Said organic dye is particularly useful in a dye sensitized photoelectric transformation element which, in its turn, can be used in a dye sensitized solar cell (DSSC). 7. A dye-sensitized photoelectric transformation element claim 1 , comprising at least one organic dye according to claim 1 , said dye-sensitized photoelectric transformation element being supported on particles of a semiconductor oxide.8. A dye-sensitized solar cell (DSSC) comprising the dye-sensitized photoelectric transformation element according to . The present invention relates to an organic dye for a dye sensitized solar cell (DSSC).More specifically, the present invention relates to an organic dye for a dye sensitized solar cell (DSSC) comprising at least one substituted pyrrole group.Said organic dye is particularly useful in a dye sensitized photoelectric transformation element which, in its turn, can be used in a dye sensitized solar cell (DSSC).Consequently, a further object of the present invention relates to a dye sensitized photoelectric transformation element comprising at least one organic dye reported above, in addition to a dye sensitized solar cell (DSSC) comprising said photoelectric transformation element.Dye sensitized solar cells (DSSCs) were developed by Grätzel M. et al. in 1991 and they have attracted considerable attention in recent years as they represent one of the photovoltaic conversion methods of solar light having the greatest potentiality in terms of photoelectric transformation efficiency (η) and in terms of production costs.Further details relating to dye sensitized solar cells (DSSCs) can be found, for example, in: Kalyanasundaram K., “-” (2010), CRC Press Inc., 1Edition; Elliott, C. M., “” (2011), Vol. 3, pages 188-189; Hagfeldt A. et al. “” (2010), Vol. 110, pages 6595-6663; Grätzel M., “” (2001), Vol. 414, pages 338-344.Dye sensitized solar cells (DSSCs) ...

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Номер записи: 56

03-02-2022 дата публикации

Organic Anion Transporting Peptide-Based Cancer Imaging and Therapy

Номер: US20220031855A1

Автор: Chung Leland W.K.

Принадлежит: Da Zen Theranostics, Inc.

A dye-drug conjugate for preventing, treating, or imaging cancer having the following structure: 2. The dye-drug conjugate according to claim 1 , wherein X is a halogen.3. The dye-drug conjugate according to claim 2 , wherein X is chloro.4. The dye-drug conjugate according to or claim 2 , wherein Rcomprises gemcitabine.5. The dye-drug conjugate according to any one of - claim 2 , wherein Rz comprises a therapeutic agent and Rcomprises an imaging moiety.6. The dye-drug conjugate according to any one of - claim 2 , wherein Rcomprises a first therapeutic agent and Rcomprises a second therapeutic agent.8. A method for diagnosis of cancer using the dye-drug conjugate according to any one of -.9. The method according to claim 8 , wherein the cancer is one selected from the group consisting of prostate cancer claim 8 , breast cancer claim 8 , renal cancer claim 8 , pancreatic cancer claim 8 , lung cancer claim 8 , and hepatic cancer.10. A method for preventing or treating cancer using the dye-drug conjugate according to any one of -.11. The method according to claim 10 , wherein the cancer is one selected from the group consisting of prostate cancer claim 10 , breast cancer claim 10 , renal cancer claim 10 , pancreatic cancer claim 10 , lung cancer claim 10 , brain tumor claim 10 , and hepatic cancer. The present application is a continuation of U.S. patent application Ser. No. 16/390,384, filed 2019 Apr. 22, which is a continuation of U.S. patent application Ser. No. 15/538,359, filed Jun. 21, 2017, which is a national stage application of, and claims the benefit to, PCT Application No. PCT/US2015/067393 filed Dec. 22, 2015, which claims priority to U.S. Patent Application Ser. No. 62/095,713, filed Dec. 22, 2014, the entire disclosures of which are incorporated herein by reference.A dye-drug conjugate for preventing, treating, or imaging cancer having the following structure:wherein Rand Rare independently selected from the group consisting of —H, alkyl, alkyl-sulphonate ...

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Номер записи: 57

18-01-2018 дата публикации

INFRARED CUT FILTER, KIT, AND SOLID-STATE IMAGING DEVICE

Номер: US20180017720A1

Автор: ARIMURA Keisuke, Hirai Yuki, MATSUMURA Tokihiko, SASAKI Daisuke, Shimada Kazuto

Принадлежит: FUJIFILM Corporation

To provide an infrared cut filter having a wide view angle and excellent infrared shieldability, a kit for manufacturing the infrared cut filter, and a solid-state imaging device. An infrared cut filter has: a copper-containing transparent layer . The copper-containing transparent layer further contains an infrared absorbing agent, or an infrared absorbing agent-containing layer is further provided. 1. An infrared cut filter comprising:a copper-containing transparent layer,wherein the copper-containing transparent layer further contains an infrared absorbing agent, or;the infrared cut filter further comprises an infrared absorbing agent-containing layer.2. The infrared cut filter according to claim 1 ,wherein a maximum absorption wavelength is shown in a wavelength region of 600 nm or greater, anda ratio B/A of, to absorbance A at the maximum absorption wavelength before the infrared cut filter is dipped in at least one organic solvent selected from propylene glycol monomethyl ether, propylene glycol monomethyl ether acetate, methyl 3-methoxypropionate, ethyl lactate, acetone, and ethanol, absorbance B at the wavelength at which the absorbance A is measured after the infrared cut filter is dipped in the organic solvent for 2 minutes at 25° C. is 0.9 or greater.3. The infrared cut filter according to claim 1 ,wherein the infrared absorbing agent-containing layer includes a resin.4. The infrared cut filter according to claim 1 ,wherein the infrared absorbing agent-containing layer includes a three-dimensional crosslinked material.5. The infrared cut filter according to claim 4 ,wherein the three-dimensional crosslinked material is formed by curing a polymerizable compound having two or more polymerizable groups.6. The infrared cut filter according to claim 1 ,wherein the infrared absorbing agent-containing layer includes gelatin.7. The infrared cut filter according to claim 1 ,wherein the infrared absorbing agent is a compound having a maximum absorption wavelength in ...

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Номер записи: 58

21-01-2021 дата публикации

SOLUTION COMPRISING A DYE

Номер: US20210017389A1

Автор: SPIJKERMAN Geesje Klasina, Steensma Maria, Talma Auke Gerardus, TATEISHI Koichi, TEN BROEKE Raymond Albertus Johannes, TER BEEK Johannes Hermanus, Ter Brake Maaike Anne Gertrud

Принадлежит: NOURYON CHEMICALS INTERNATIONAL B.V.

Solution comprising about 1 to about 25 wt % of a dye that loses its colour during radical cure and about 75 to about 99 wt % of a solvent mixture, said solvent mixture comprising cyclopentanone and dimethylsulphoxide in a weight ratio of about 60:40 to about 95:5. 3. Solution according to wherein Y is —NO.4. Solution according to wherein Rhas the structure —CH—C≡N.5. Solution according to wherein Rhas the structure —CH.6. Solution according to wherein Rhas the structure —CH—O—C(═O)—O—CH.7. Solution according to wherein Rhas the structure —CH—O—C(═O)—CH.9. Solution according to wherein Y is —NO.10. Solution according to wherein either Ror Rhas the structure —CH—C≡N.11. Solution according to wherein Rhas the structure —CH.12. Solution according to wherein Rhas a structure chosen from —CH—OH claim 8 , —CH—O—C(═O)—O—CH claim 8 , ——CH—O—C(═O)—CH claim 8 , and —CH—C(═O)—O—CH1.13. Peroxide formulation comprising:one or more organic peroxides and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'about 0.05 to about −2.0 wt % of the solution according to ,'}wherein the active oxygen content of the formulation is from about 2 to about −15 wt %.14. Peroxide formulation according to wherein the organic peroxide is chosen from ketone peroxides claim 13 , organic hydroperoxides claim 13 , peroxyesters claim 13 , and combinations thereof.15. Process for curing a radically curable resin comprising the step of adding a peroxide formulation according to to the resin.16. Solution according to wherein Ris ethyl or has the structure{'br': None, 'sub': 2', '2, 'CH—CH—C≡N; or'}{'br': None, 'sub': 2', '4', '2', '5, '—CH—O—C(═O)—O—CH; or'}{'br': None, 'sub': 2', '4', '3, '—CH—O—C(═O)—CH.'}17. Solution according to wherein either Ror Rhas the structure —CH—CH—C≡N.18. Solution according to wherein Ris ethyl.19. Peroxide formulation according to wherein the organic peroxide is chosen from acetylacetone peroxide claim 13 , tert-butyl peroxybenzoate claim 13 , methyl ethyl ketone peroxide claim ...

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Номер записи: 59

17-01-2019 дата публикации

DISPLAY DEVICE

Номер: US20190018273A1

Автор: Kim Jin Suek, Lee Sang Hun, OH Se Joon, Park Sae Ron, Ryu Hyun Soo

Принадлежит:

A display device includes: a light unit for emitting blue light; a color conversion panel on the light unit; a display panel between the light unit and the color conversion panel, the display panel comprising transistors; and column spacers between the transistors and the color conversion panel, the column spacers overlapping the transistors. The color conversion panel includes: a substrate; color conversion layers between the substrate and the display panel, the color conversion layers comprising semiconductor nanocrystals; a transmission layer between the substrate and the display panel; and polarization layers between the color conversion layers and the display panel and between the transmission layer and the display panel. The column spacers include a pigment that absorbs blue light. 1. A display device comprising:a light unit configured to emit blue light;a color conversion panel on the light unit;a display panel between the light unit and the color conversion panel, the display panel comprising transistors; andcolumn spacers between the transistors and the color conversion panel, the column spacers overlapping the transistors,wherein the color conversion panel comprises:a substrate;color conversion layers between the substrate and the display panel, the color conversion layers comprising semiconductor nanocrystals;a transmission layer between the substrate and the display panel; andpolarization layers between the color conversion layers and the display panel and between the transmission layer and the display panel, andwherein the column spacers comprise a pigment that absorbs blue light.2. The display device of claim 1 , wherein the pigment comprises at least one of a red pigment claim 1 , an orange pigment claim 1 , or a yellow pigment.3. The display device of claim 1 , wherein the pigment is included in an amount of about 5 wt % to about 30 wt % with respect to a total amount of the column spacers.5. The display device of claim 1 , wherein a height of the ...

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Номер записи: 60

17-04-2014 дата публикации

Reduced dye probes for the detection of radical oxygen species

Номер: US20140105826A1

Автор: Kousik Kundu, Niren Murthy, Sarah F. Knight, Sungmun Lee, W. Robert Taylor

Принадлежит: EMORY UNIVERSITY, Georgia Tech Research Corp

Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes capable of detecting one or more reactive oxygen species are described herein. The reduced dyes exhibit little or no fluorescence due to the disrupted π conjugation. However, upon reaction with ROS, the reduced dyes are oxidized, regenerating the extended π conjugation and causing a substantial increase in fluorescence intensity. In many case, the oxidized dye is generally membrane impermeable. However, upon reduction, many of the reduced dyes are membrane permeable. Thus, reduced dyes can accumulate in cells and/or tissue to amplify the signal. Once inside the cell or tissue, the reduced dye is reoxidized upon reaction with ROS, and the oxidized dye again becomes membrane impermeable, trapping the dye within the cell. The reduced dyes can be used to image ROS, such as hydroxide radical and superoxide, in serum, cell cultures, tissue explants, and in vivo.

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Номер записи: 61

28-01-2016 дата публикации

METHOD OF FABRICATING A LIQUID CRYSTAL POLYMER FILM

Номер: US20160023993A1

Автор: Kimball Brian R., Nersisyan Sarik R., Steeves Diane M., Tabirian Nelson V., Vergara Rafael O.

Принадлежит:

A method of fabricating a liquid crystal polymer film includes providing a support substrate having a surface having a shape arranged to define a form of a liquid crystal polymer film to be fabricated; applying a layer of a photoaligning material over the surface of the support substrate, the photoaligning material having an absorption band; exposing the layer of photoaligning material to a light having a linear polarization and the light comprising a wavelength within the absorption band to convert the layer of photoaligning material into a layer of photoaligned material; applying a layer of a polymerizable liquid crystal over the layer of photoaligned material; performing photopolymerization of the layer of polymerizable liquid crystal to form a liquid crystal polymer film; applying a solvent to the layer of photoaligned material, the solvent formulated to dissolve the photoaligned material to thereby release the liquid crystal polymer film from the support substrate; and removing the liquid crystal polymer film from the support substrate. 1. A method of fabricating a liquid crystal polymer film , the method comprising:(a) providing a support substrate having a surface having a shape arranged to define a form of a liquid crystal polymer film to be fabricated;(b) applying a layer of a photoaligning material over said surface of said support substrate, said photoaligning material having an absorption band;(c) exposing said layer of photoaligning material to a light having a linear polarization and said light comprising a wavelength within said absorption band to convert said layer of photoaligning material into a layer of photoaligned material;(d) applying a layer of a polymerizable liquid crystal over said layer of photoaligned material;(e) performing photopolymerization of said layer of polymerizable liquid crystal to form a liquid crystal polymer film of about 1 μm in thickness;(f) applying a solvent to said layer of photoaligned material, said solvent formulated ...

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Номер записи: 62

26-01-2017 дата публикации

Storage-stable dye solutions

Номер: US20170022366A1

Автор: Friedrich Lehr

Принадлежит: Archroma IP GmbH

The present invention relates to storage-stable dye salts, solutions and compositions thereof a process for their preparation and their use for dyeing and/or printing substrates.

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Номер записи: 63

29-01-2015 дата публикации

Aza-Benzazolium Containing Cyanine Dyes

Номер: US20150031579A1

Автор: Richard Haugland, Stephen Yue

Принадлежит: Life Technologies Corp

Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or when associated with detergent-complexed proteins. A variety of applications are described for detection and quantitation of nucleic acids and detergent-complexed proteins in a variety of samples, including solutions, electrophoretic gels, cells, and microorganisms.

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Номер записи: 64

17-02-2022 дата публикации

CHEMILUMINESCENT PROBES FOR DIAGNOSTICS AND IN VIVO IMAGING

Номер: US20220047725A1

Автор: Eilon Tal, Green Ori, Hananya Nir, Satchi-Fainaro Ronit, Shabat Doron

Принадлежит:

The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging. 3. The conjugate of claim 2 , wherein Rand Rtogether with the carbon atom to which they are attached form adamantyl.4. The conjugate of claim 2 , wherein Xis —(CH)-para-phenylene; and Xis —C(O)—.5. The conjugate of claim 1 , wherein:{'sup': '1', 'sub': 1', '8, 'Ris a linear or branched (C-C)alkyl;'}{'sup': 2', '3, 'Rand Rtogether with the carbon atom to which they are attached form a fused, spiro or bridged polycyclic ring;'}{'sup': 7', '8', '9', '7', '8', '9, 'sub': '2', 'at least one of R, Rand Ris H, and the other of R, Rand Reach independently is an electron acceptor group selected from the group consisting of halogen, —NOand —CN; and'}{'sub': 1', '2', '1', '1', '18', '6', '14', '1', '18', '6', '14', '2', '2', '2', '2', '2', '3', '6', '10', '1', '4', '6', '10', '1', '4', '1', '18', '1', '8', '6', '10', '6', '10', '2, 'X is a linker of the formula —X—X—, wherein Xis (C-C)alkylene, (C-C)arylene-diyl, or (C-C)alkylene-(C-C)arylene-diyl, optionally substituted by one or more groups each independently selected from the group consisting of halogen, —COH, —COOH, —OCOOH, —OCONH, —CN, —NO, —SH, —OH, —NH, —CONH, —SOH, —SOH, —S(═O)H, (C-C)aryl, (C-C)alkylene-(C-C)aryl, heteroaryl, and (C-C)alkylene-heteroaryl, and said (C-C)alkylene being further optionally interrupted by one or more identical or different heteroatoms selected from the group consisting of S, O and N, and/or at least one group each independently selected from the group consisting of —NH—CO—, —CO—NH—, —N(C-Calkyl)-, —N(C-Caryl)-, (C-C)arylene-diyl, and heteroarylenediyl; and Xis —C(O)—.'}6. The conjugate of claim 5 , wherein Ris methyl; Rand Rtogether with the carbon atom to which they are attached form adamantly; Xis —(CH)-para-phenylene; ...

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Номер записи: 65

04-02-2016 дата публикации

FLUORESCENT COMPOUNDS

Номер: US20160033520A1

Автор: Cheung Ching-Ying, Hoover Hye Eun, Leung Wai-Yee, Mao Fei

Принадлежит:

The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions. 124-. (canceled)26. (canceled)27. The compound of wherein when the two adjacent Rand/or the two adjacent Rare combinable to form a 6-membered ring and the ring so formed is aromatic.28. (canceled)30. The compound of claim 25 , wherein at least one R of Rand Ris a charged moiety.31. The compound of claim 25 , wherein at least one R of Rand Rcomprises a sulfonate group or a phosphonate group.32. The compound of claim 25 , wherein each R of Rand Rcomprises a sulfonate group or a phosphonate group.3335-. (canceled)36. The compound of claim 25 , wherein the water-soluble polymer is a polyethylene oxide.3739-. (canceled)40. The compound of claim 25 , wherein two adjacent (R)and the atoms in ring A to which it is attached are combined to form a carbocyclic ring.41. The compound of claim 40 , wherein the carbocyclic ring is aromatic.42. The compound of claim 25 , wherein two adjacent (R)and the atoms in ring B to which it is attached are combined to form a carbocyclic ring.43. The compound of claim 42 , wherein the carbocyclic ring is aromatic.45. (canceled)47. (canceled)5076-. (canceled)77. A kit comprising:{'claim-ref': {'@idref': 'CLM-00025', 'claim 25'}, 'i) the compound of ; ii) a buffer; iii) materials or devices for purifying conjugation products; and iv) instructions instructing the use of the compound.'}78. A biomolecule comprising a label having a structure of a Formula of claim 25 , wherein the at least one reactive moiety of the Formula has undergone a reaction which attaches the label to the biomolecule. ...

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Номер записи: 66

30-01-2020 дата публикации

Compositions of Near IR Closed Chain, Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands

Номер: US20200030461A1

Автор: Sorger Jonathan M.

Принадлежит:

Compositions and methods for visualizing tissue under illumination with fusion compounds of near-infrared radiation using near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are provided. 4. The composition of claim 1 , wherein the composition is a pharmaceutical composition comprising a unit dosage form of a compound of formula I wherein claim 1 , the composition is adapted for administration to a patient; andwherein, the unit dosage form of the compound delivers to the patient an amount between 0.01 and 8 mg/kg.5. The composition of claim 4 , wherein the composition unit dosage form delivers to the patient the amount of 0.01 claim 4 , 0.05 claim 4 , 0.10 claim 4 , 0.20 claim 4 , 0.30 claim 4 , 0.35 claim 4 , 0.40 claim 4 , 0.45 claim 4 , 0.50 claim 4 , 0.55 claim 4 , 0.60 claim 4 , 0.65 claim 4 , 0.70 claim 4 , 0.75 claim 4 , 0.80 claim 4 , 0.90 claim 4 , 1 claim 4 , 2 claim 4 , 4 claim 4 , 6 claim 4 , or 8 mg/kg.6. The composition of where the composition is dry and a single dose form.7. The composition of where the composition is lyophilized in a sterile container.8. The composition of where the composition is contained within a sterile container claim 4 , where the container has a machine detectable identifier which is readable by a medical device.9. The composition of further comprising combination with pharmaceutically acceptable excipients in an oral dosage form.10. The composition of further comprising combination with pharmaceutically acceptable carriers in an injectable dosage form.11. The composition of further comprising combination with pharmaceutically acceptable excipients in a dosage form for direct delivery to a surgical site.13. The method of claim 12 , wherein the composition is a pharmaceutical composition comprising a unit dosage form of a compound of formula I wherein claim 12 , the composition is sterile claim 12 , non-toxic claim 12 , and adapted for administration to a patient; andwherein, the unit ...

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Номер записи: 67

17-02-2022 дата публикации

Process for the Purification of Methylene Blue

Номер: US20220049102A1

Автор: Kannappan Jayaraman, Kovi Ravishanker, Mande Hemant, Raghavulu Dusanapudi Naga Venkata

Принадлежит:

The present application provides method for producing methylene blue that includes the steps of providing a reaction mixture having one or more methylene blue intermediates; precipitating metal from the reaction mixture; and producing therefrom crude methylene blue. The crude may further be purified, resulting in methylene compounds having low impurities, preferably having a purity greater than about 97%, having Azure B impurity no greater than 2.5%, and/or a total metal content no greater than 77 ppm. Formulations containing such compounds are also provided. 1. A compound comprising methylene blue having a purity greater than about 97%.2. The compound of claim 1 , the methylene blue further having Azure B impurity no greater than 2.5%.3. The compound of claim 1 , the methylene blue further having total metal content no greater than 77 ppm.4. A method for producing methylene blue comprising:providing a reaction mixture comprising one or more methylene blue intermediates;precipitating metal from the reaction mixture; andproducing therefrom crude methylene blue.5. The method of claim 3 , comprising extracting a solvent from the reaction mixture claim 3 , wherein the step of precipitating the metal from the reaction mixture is performed during solvent extraction.6. The method of claim 5 , wherein solvent extraction is performed with the reaction mixture having a pH between about pH 9 and about pH 11.7. The method of claim 3 , wherein methylene blue crude is produced in-situ without isolation of any intermediate(s).8. The method of claim 3 , wherein providing the reaction mixture comprises:reacting N,N-dimethylaniline with sodium nitrite in hydrochloric acid to obtain an in-situ nitroso compound;reducing the in-situ nitroso compound in the presence of zinc and hydrochloric acid to get obtain in-situ p-amino dimethyl aniline;reacting the in-situ p-amino dimethyl aniline with sulfuric acid and zinc chloride in a presence of sodium thiosulfate pentahydrate, sodium ...

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Номер записи: 68

30-01-2020 дата публикации

SENSOR DYES FOR REAL-TIME SENSING OF METAL IONS IN AQUEOUS ENVIRONMENTS

Номер: US20200033314A1

Автор: Bathurst Bruce, Fenske Tyler G., Geissinger Peter, Hagemann Trevor, Henning Paul, Oehm Sarah, Schwabacher Alan

Принадлежит:

Provided herein are dyes for detecting and distinguishing metals in a sample, as well as compositions and methods comprising the same. 1. A sensor comprising at least one dye covalently bound to an optically transparent substrate; wherein the dye reversibly binds at least one metal ion.2. The sensor of comprising a panel claim 1 , the panel comprising the optically transparent substrate and more than one dye covalently bound to the optically transparent substrate; wherein the dye reversibly binds the at least one metal ion.7. The sensor of claim 1 , wherein the optically transparent substrate is a polymer.8. (canceled)9. The sensor of claim 1 , wherein the optically transparent substrate further comprises a perturbation moiety.10. The sensor of claim 9 , wherein the perturbation moiety is a cation claim 9 , an anion or a zwitterion or a neutral species.11. (canceled)12. The sensor of comprising a plurality of different dyes.13. The sensor of claim 2 , wherein the panel comprises more than one optically transparent substrate;wherein each optically transparent substrate has a dye capable of sensing more than one metal covalently bound to the substrate.14. The sensor of claim 1 , wherein the covalent bond is an ether bond claim 1 , an amide bond claim 1 , a sulfonamide bond claim 1 , a urethane or an alkene.17. The sensor of claim 15 , wherein the linker is selected from the group consisting of —O—(CH)—CH— claim 15 , wherein p is an integer from 1 to 4; —OCHC(O)NH—(CHO)CHCH—NHC(O)— claim 15 , wherein t is an integer from 1 to 10; —O—(CHO)—C(O)NH— claim 15 , wherein r is an integer from 1 to 10; —C(O)NH—(CHO)—CHCHNHC(O)—(OCH)OC(O)— claim 15 , wherein q and v are independently an integer from 1 to 10; and —O—(CHO)C(O)— claim 15 , wherein u is an integer from 1 to 10.18. A method of detecting at least one metal ion in an aqueous solution comprising contacting the aqueous solution with the sensor of ; obtaining a signal for the sensor; analyzing the signal; and identifying ...

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Номер записи: 69

11-02-2016 дата публикации

VITAL STAIN

Номер: US20160041100A1

Автор: FUJIWARA Takeshi, Kimura Kazushi, Mizoguchi Akira, SAI Kousyoku, Tanaka Koji, WANG Shujie

Принадлежит:

A vital stain for observation under multiphoton laser microscopy, the vital stain comprising one or more edible dye compounds. 1. A vital stain for observation under multiphoton laser microscopy , comprising one or more edible dye compounds that are USFDA (Food and Drug Administration)-approved or Japanese Ministry of Health , Labour and Welfare-approved food additives ,wherein the dye compound is selected from the group of fluorescent dye compounds including tar-based dyes, iridoid dyes, carotenoid-based dyes, flavonoid-based dyes, quinoid-based dyes and betalain-based dyes,the tar-based dyes being Red #3 (erythrosine), Red #104 (phloxine), Red #105, Red #106, Green #3 (Fast Green FCF) and Blue #2 (indigo carmine),{'i': Gardenia', 'Gardenia, 'the carotenoid-based dyes being annatto (annatto-N2R25, achiote fruit: bixin, norbixin), crocin G150 (Yellow dye), crocin L (Yellow dye), β-carotene and annatto-WA-20 (annatto dye achiote seed: norbixin),'}the flavonoid-based dyes being HI RED V80 (purple potato dye: cyanidin acyl glucoside and peonidin acyl glucoside), malvidin (blue sweet pea dye), tricetinidin (black tea dye), petunidine (red berry dye), curcumin, sulfuretin, myricetin (grape, onion dye) and quercetin (onion, citrus dye),the betalain-based dye being HI RED BL (red beet dye: betanin, isobetanin),and the vital stain stains luminal epithelial/adenocytic and/or connective tissue/capillary cancer cells.211-. (canceled)12. The vital stain according to claim 1 , wherein the dye compound is excited with a multiphoton laser of 700 nm or longer.13. A method of observing cells obtained from a subject or cultured cells claim 1 , using a vital stain according to claim 1 , the method comprising:1) applying the vital stain to the cells,2) observing the cells under a multiphoton laser microscope, and3) distinguishing between normal cells and cancer cells based on differences in stainability between the cells.14. (canceled)15. A method of evaluating the cell staining ...

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Номер записи: 70

11-02-2016 дата публикации

Method for Detecting and Monitoring Bone Loss

Номер: US20160041190A1

Автор: Andre ST. AMANT, Colleen Nicole Biggs, Hon Sing LEONG, John D. Lewis, Leonard Luyt, Leonard MINUK

Принадлежит: London Health Sciences Centre Research Inc

Methods for identifying subjects having bone loss by detecting bone microparticles in a sample of their bodily fluid are disclosed. Methods for monitoring bone loss and assessing efficacy of bone loss therapies by detecting bone microparticles in bodily fluid samples are also disclosed. Compounds for use as a negative control in the disclosed methods are provided as well as kits comprising such compounds.

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Номер записи: 71

06-02-2020 дата публикации

Nanoprobe-Metal Chelator Complexes

Номер: US20200040189A1

Автор: Choi Hak Soo, Fakhri Georges El, KIM Jonghan

Принадлежит:

Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided. 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein A comprises one or more cationic groups each independently selected from the group consisting of ammonium claim 1 , Calkylammonium claim 1 , di(Calkyl)ammonium claim 1 , tri(Calkyl)ammonium claim 1 , a cationic 5-10 membered heteroaryl group claim 1 , and a cationic 4-10 membered heterocycloalkyl group claim 1 , wherein the cationic 5-10 membered heteroaryl group and cationic 4-10 membered heterocycloalkyl group are each optionally substituted by 1 claim 1 , 2 claim 1 , 3 claim 1 , or 4 independently selected Calkyl groups.34.-. (canceled)5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein A comprises one or more anionic groups each independently selected from the group consisting of oxide claim 1 , carbonate claim 1 , carboxylate claim 1 , phosphate claim 1 , sulfide claim 1 , sulfinate claim 1 , and sulfonate.6. (canceled)817.-. (canceled)19. (canceled)20. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein B is selected from the group consisting of polylysine claim 1 , polylactic acid claim 1 , poly(lactic-co-glycolic acid) claim 1 , polyaspartic acid claim 1 , polyglutamic acid claim 1 , and polyglutamic acid-poly(ethylene glycol) copolymer claim 1 , each of which is substituted by one or more C groups and one or more -D-E groups.2124.-. (canceled)25. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein each C is independently selected from the group consisting ...

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Номер записи: 72

06-02-2020 дата публикации

NIR FLUORESCENT PROBE FOR LABELING MITOCHONDRIA

Номер: US20200040190A1

Автор: HONG Kyung-Tae, HONG Seong-Cheol, KIM Yun-kyung, Lee Jun-seok, Lee Seok, MURALE Dhiraj P.

Принадлежит:

Disclosed is a fluorescent probe specifically labeling mitochondria, which can exhibit high transmittance by virtue of light emission in the NIR range and in which nonspecific fluorescence absorption in biomolecules can be avoided, making it possible to observe fluorescence images in deep tissue. 2. The compound of claim 1 , wherein the compound is used to label mitochondria.3. The compound of claim 2 , wherein the compound generates a red fluorescence.5. The fluorescent probe of claim 4 , wherein the fluorescent probe generates a red fluorescence.6. A method of detecting mitochondria using the compound represented by Chemical Formula 1 of .7. The method of claim 6 , comprising:preparing a solution by dissolving the compound represented by Chemical Formula 1 in a solvent; andadding the solution to a sample including cells.8. The method of claim 7 , further comprising:applying light at a predetermined wavelength to the sample added with the compound represented by Chemical Formula 1; andmeasuring a fluorescence emitted from the sample.12. The method of claim 11 , wherein the compound represented by Chemical Formula 2 is formed by dissolving 2 claim 11 ,4-dimethylpyrrole and 4-nitrobenzaldehyde in dichloromethane claim 11 , carrying out a reaction with addition of trifluoroacetic acid claim 11 , carrying out a reaction with addition of 2 claim 11 ,3-dichloro-5 claim 11 ,6-dicyano-1 claim 11 ,4-benzoquinone dissolved in dichloromethane claim 11 , carrying out a reaction with addition of diisopropylethylamine claim 11 , and carrying out a reaction with addition of boron trifluoride etherate.13. The method of claim 9 , wherein the compound represented by Chemical Formula 1 generates a red fluorescence. The present application claims the benefit of Korean Patent Application No. 10-2018-0090484 filed on Aug. 2, 2018.The present invention relates to a near-infrared (NIR) florescent probe for labeling mitochondria.Cell-organelle-based proteomics enables the diagnosis and ...

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Номер записи: 73

01-05-2014 дата публикации

METHOD FOR POLYMERIZNG VINYLIDENE FLUORIDE

Номер: US20140121321A1

Автор: Brinati Giulio, KAPELYUSHKO Valeriy, Kent Bradley Lane, Veneroni Alessandro

Принадлежит: SOLVAY SPECIALTY POLYMERS ITALY S.P.A.

A process for manufacturing a dispersion of a vinylidene fluoride (VDF) thermoplastic polymer [polymer (F)], said process comprising polymerizing VDF in an aqueous phase comprising from 0.5 to 1.5 g/l of at least one surfactant of formula F—(CFCF)—CHCH—SOX, wherein Xis H, a alkali metal or a NRgroup, with Rbeing H or a C-Chydrocarbon group [surfactant (T)] and an organic oxidizing agent [agent (O)] as polymerization initiator. 1. A process for manufacturing a dispersion of a vinylidene fluoride (VDF) thermoplastic polymer [polymer (F)] , said process comprising polymerizing VDF in an aqueous phase , the aqueous phase comprising:{'sub': 2', '2', '3', '2', '2', '3', 'a', 'a', '4', '1', '6, 'sup': H', 'H, 'from 0.5 to 1.5 g/l of at least one surfactant of formula F—(CFCF)—CHCH—SOX, wherein Xis H, a alkali metal or a NRgroup, with Rbeing H or a C-Chydrocarbon group [surfactant (T)] and'}an organic oxidizing agent [agent (O)] as polymerization initiator.2. The process of claim 1 , wherein said polymer (F) is a polymer comprising:(a′) at least 60% by moles of vinylidene fluoride (VDF);(b′) optionally from 0.1 to 15% by moles of a fluorinated monomer different from VDF; and(c′) optionally from 0.1 to 5% by moles, based on the total amount of monomers (a′) and (b′), of one or more hydrogenated comonomer(s).3. The process of claim 1 , wherein the aqueous phase comprises an amount of 0.8 to 1.2 g/l of surfactant (T).4. The process of claim 1 , wherein the aqueous phase further comprises an additional surfactant different from surfactant (T) claim 1 , said additional surfactant complying with formula:{'br': None, 'sub': 2', '2', 'n', '2', '2', '3', 'a, 'F—(CFCF)—CHCH—SOX′,\u2003\u2003[surfactant (Q)]'}wherein n is equal to 2 or in the range 4-7, and{'sub': a', '4', '1', '6, 'sup': H′', 'H′, 'X′is H, a alkali metal or a NRgroup, with Rbeing H or a C-Chydrocarbon group.'}5. The process of claim 4 , wherein the weight percent of surfactant (T) claim 4 , based on the overall ...

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Номер записи: 74

01-05-2014 дата публикации

PERMANENT ATTACHMENT OF AGENTS TO SURFACES CONTAINING C-H FUNCTIONALITY

Номер: US20140121333A1

Автор: Locklin Jason J.

Принадлежит:

An embodiment of the present disclosure can include a compound, a structure bonded to the compound, and the like. In an embodiment, the compound can be a linker between an agent and a structure, where the agent can be a dye or a pigment and the structure can be a fiber, hair, or another structure. In an embodiment, the compound can be a linker between an agent and a structure, where the agent can be a fluorinated compound and the structure can be a counter top, metal, or the like. 1. A compound comprising:R1-(C═O)—R2-X—W, where R1 and R2 are independently selected from the group consisting of: a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heteroaryl group; X is selected from the group consisting of: O, NR3, a substituted or unsubstituted alkyl group, a S group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heteroaryl group; wherein R3 is selected from the group consisting of: a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heteroaryl group; and wherein W is a pigment or a dye.2. The compound of claim 1 , wherein one of R1 and R2 is a substituted or unsubstituted aryl group.3. The compound of claim 1 , wherein both of R1 and R2 is a substituted or unsubstituted aryl group.4. The compound of claim 1 , wherein one of R1 and R2 is a substituted or unsubstituted phenyl group.5. The compound of claim 1 , wherein both of R1 and R2 is a substituted or unsubstituted phenyl group.6. An article comprising:R1-(C(Struc)OH)—R2-X—W, where R1 and R2 are independently selected from the group consisting of: a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heteroaryl group; X is selected from the group consisting of: O, NR3, a substituted or unsubstituted alkyl group, a S group, a substituted or unsubstituted aryl group, ...

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Номер записи: 75

16-02-2017 дата публикации

Novel ir dyes and laser markable articles comprising such ir dyes

Номер: US20170043602A1

Автор: Marin STEENACKERS

Принадлежит: Agfa Gevaert NV

Infrared dyes having an infrared absorption maximum above 1130 nm with minor colouration in the visual spectrum. The infrared dyes are especially useful for producing multicolour laser marked security documents having reduced background coloration and enhanced colour gamut.

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Номер записи: 76

03-03-2022 дата публикации

Delocalized Lipophilic Cation Compounds and Methods of Use Thereof

Номер: US20220064140A1

Автор: Chen Hao, Cheng Zhen

Принадлежит:

Provided are delocalized lipophilic cation (DLC) compounds and methods of using such compounds. Also provided are pharmaceutical compositions that include a DLC compound. Provided methods include methods of killing cells and methods of fluorescently labeling mitochondria by contacting the cells with a DLC compound of the present disclosure. Also provided are methods of imaging cell mitochondria, methods of determining whether a patient has a mitochondria related disease, and methods of treating a patient for a mitochondria related disease. Kits that include compounds of the present disclosure are also provided.

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Номер записи: 77

14-02-2019 дата публикации

Excitonic quantum computing mediated by chromophore-embedded 1-, 2-, and 3-dimensional dna scaffolds

Номер: US20190048036A1

Автор: Bernard Yurke, William B. Knowlton

Принадлежит: BOISE STATE UNIVERSITY

Using nucleotide architectures to very closely and precisely placed chromophores that produce quantum coherent excitons, biexcitons, and triexcitons upon excitement to create excitonic quantum wires, switching, and gates that would then form the basis of quantum computation. Creating the various excitons and controlling the timing of the excitons would be performed using light of the corresponding wavelength and polarization to stimulate the corresponding chromophores.

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Номер записи: 78

25-02-2016 дата публикации

Azo dye used for a color filter of a lcd

Номер: US20160053120A1

Автор: Guihong LIAO, Nan Hu, Tianhui Xiao, Xiangyang Tai, Xinyu Cao

Принадлежит: Dow Chemical Co

An azo dye which is suitable for forming a color filter used for a liquid crystal display device, a composition containing an alkaline soluble resin and the azo dye, an article having a polymer layer containing the azo dye and an alkaline soluble resin and a color filter containing the dye are developed.

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Номер записи: 79

25-02-2021 дата публикации

APPLYING HANSEN SOLUBILITY PARAMETERS TO METAL-ORGANIC FRAMEWORK SYNTHESIS CONDITIONS

Номер: US20210053903A1

Автор: Abney Carter W., Ivashko Anna C.

Принадлежит:

A method suitable for use in investigating synthesis conditions for metal-organic frameworks may include: identifying synthesis conditions that includes a first solvent system by which a metal-organic framework is successfully synthesized; and synthesizing the metal-organic framework under substantially the same synthesis conditions but with a second solvent system (or a comparable solvent system) having a difference (R) between Hansen solubility parameters of 5 MPaor less as compared to the first solvent system. 1. A method comprising:identifying synthesis conditions that include a first solvent system by which a metal-organic framework is successfully synthesized; and{'sub': 'a', 'sup': '0.5', 'synthesizing the metal-organic framework under substantially the same synthesis conditions but with a second solvent system that is different from the first solvent system, wherein the second solvent system has a difference (R) between Hansen solubility parameters of 5 MPaor less as compared to the first solvent system.'}2. The method of claim 1 , where the second solvent system has a comparable dispersion parameter (δ) and a comparable polarity parameter (δ) and a comparable hydrogen bonding parameter (δ) relative to the first solvent system.3. The method of claim 1 , wherein the metal-organic framework is MOF-274.4. The method of claim 3 , wherein the synthesis conditions includes a linker comprising 4 claim 3 ,4′-dihydroxybiphenyl-3 claim 3 ,3′-dicarboxylic acid (HDOBPDC).5. The method of claim 3 , wherein the second solvent system and the first solvent system have a dispersion parameter (δ) of 15 MPato 17 MPaand the polarity parameter (δ) of 6 MPato 15 MPaand the hydrogen bonding parameter (δ) of 12 MPato 18 MPa.6. The method of claim 3 , wherein the second solvent system comprises at least one solvent selected from the group consisting of tetrahydrofuran claim 3 , water claim 3 , acetonitrile claim 3 , acetone claim 3 , toluene claim 3 , dimethylsulfoxide claim 3 , ...

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Номер записи: 80

23-02-2017 дата публикации

Azoaryls as reversibly modulatable tubulin inhibitors

Номер: US20170051149A1

Автор: Dirk Trauner, Jens Hasserodt, Malgorzata Borowiak, Oliver THORN-SESHOLD

Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, ECOLE NORMALE SUPERIEURE DE LYON, Ludwig Maximilians Universitaet Muenchen LMU, Universite Claude Bernard Lyon 1 UCBL

The invention concerns a new class of tubulin polymerisation inhibitors and their applications in research and medicine, notably in chemotherapy. The invention proposes new azoaryl derivatives of formula (I): as defined in Claim 1 , which may be fully reversibly interconverted between non-tubulin-binding trans and tubulin-binding as isomeric forms, either by irradiation or spontaneously. The invention also concerns compounds with a azoaryl structure for use in studying the cytoskeleton and/or its associated processes, or in the treatment of a disease for which a tubulin polymerisation inhibition activity has a beneficial effect, wherein the compound is administered to the cell, organism or patient in need of such treatment in the trans form of the diazenyl bond, and where this trans form is inactive as regards a tubulin polymerisation inhibition effect, and where after photoisomerisation in vitro, in cellulo or in vivo to an azoaryl compound in its cis isomeric form of the diazenyl bond by the application of light, optionally with modification in vitro, in cellulo or in vivo of one or more substituents, the resultant cis form is active as regards a tubulin polymerisation inhibition effect.

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Номер записи: 81

25-02-2021 дата публикации

COLORS FOR CHROMOGENIC IHC AND ISH STAINING WITH MULTI-DYE QUINONE METHIDE AND TYRAMIDE CONJUGATES

Номер: US20210055285A1

Автор: Ashworth-Sharpe Julia, Kelly Brian D., Lefever Mark, Polaske Nathan W.

Принадлежит:

Disclosed herein are novel chromogenic conjugates, the conjugates comprising at least two detectable moieties. 1. A two-chromogen conjugate comprising: (a) a first chromogen , and (b) a second chromogen , wherein the first and second chromogens are coupled via a multi-functional linker , and wherein the conjugate further comprises a terminal reactive functional group.2. The two-chromogen conjugate of claim 1 , wherein the multi-functional linker comprises lysine or a derivative of lysine.3. The two-chromogen conjugate of claim 1 , wherein the multi-functional linker comprises lysine.4. The two-chromogen conjugate of claim 1 , wherein the multi-functional linker is a heterobifunctional linker.5. The two-chromogen conjugate of claim 1 , wherein the multi-functional linker is a dendrimer selected from the group consisting of polyamidoamine (PAMAM) dendrimers claim 1 , Janus dendrimers claim 1 , and bis-MPA dendrimers.6. The two-chromogen conjugate of claim 1 , wherein the first and second chromogens are independently selected from the group consisting of a rhodamine or a derivative or an analog thereof claim 1 , Dabsyl or a derivative or an analog thereof claim 1 , Dabcyl or a derivative or an analog thereof claim 1 , Cy3 or a derivative or an analog thereof claim 1 , Cy7 or a derivative or an analog thereof claim 1 , Cy3.5 or a derivative or an analog thereof claim 1 , Cy3B or a derivative or an analog thereof claim 1 , Cy5 or a derivative or an analog thereof claim 1 , Cy5.5 or a derivative or an analog thereof claim 1 , and fluorescein or a derivative or an analog thereof.7. The two-chromogen conjugate of claim 1 , wherein one of the first and second chromogens comprises a cyanine-based-dye.8. The two-chromogen conjugate of claim 7 , wherein the two-chromogen conjugate produces a blue or a blue-like color.9. The two-chromogen conjugate of claim 7 , wherein the two-chromogen conjugate produces a red or a red-like color.10. The two-chromogen conjugate of claim 7 , ...

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Номер записи: 82

10-03-2022 дата публикации

WATER-BASED INKJET YELLOW INK, INK SET, AND METHOD FOR PRODUCING PRINTED MATTER

Номер: US20220073772A1

Автор: JONAI Kazuhiro, SUZUKI Norio, Yoda Atsushi

Принадлежит:

One embodiment relates to a water-based inkjet yellow ink containing a yellow pigment (A) having a specific partial structure, an organic solvent, a basic organic compound, and water, wherein an amount of the yellow pigment (A) is 1 to 10% by mass of a total mass of the water-based inkjet yellow ink, the basic organic compound contains 0.1 to 1.25% by mass of a basic organic compound (B) having a pKa value of 9.5 or less at 25° C. of the total mass of the water-based inkjet yellow ink, and an amount of an organic solvent having a boiling point of 240° C. or higher under 1 atmosphere is 5% by mass or less of the total mass of the water-based inkjet yellow ink. 2. The water-based inkjet yellow ink according to claim 1 , whereinan amount of the basic organic compound (B) having a pKa value of 9.5 or less at 25° C. is 0.1 to 1% by mass of the total mass of the water-based inkjet yellow ink.3. The water-based inkjet yellow ink according to claim 1 , whereinthe yellow pigment (A) includes C. I. Pigment Yellow 139 and/or C. I. Pigment Yellow 185.4. The water-based inkjet yellow ink according to claim 1 , whereinan amount of impurities contained in the yellow pigment (A) is 5% by mass or less of a total mass of the yellow pigment (A).5. A inkjet ink set comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the water-based inkjet yellow ink according to , and'}a water-based inkjet magenta ink containing a magenta pigment and water.7. The inkjet ink set according to claim 6 , whereinthe magenta pigment having a partial structure represented by general formula (2) includes at least one selected from the group consisting of C. I. Pigment Red 146, C. I. Pigment Red 147, C. I. Pigment Red 150, C. I. Pigment Red 185, C. I. Pigment Red 266, and C. I. Pigment Red 269.8. The inkjet ink set according to claim 5 , further comprising a water-based inkjet cyan ink claim 5 , whereinthe water-based inkjet cyan ink includes at least one selected from the group consisting of C. I. ...

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Номер записи: 83

01-03-2018 дата публикации

COLORING COMPOSITION, FILM, COLOR FILTER, PATTERN FORMING METHOD, METHOD FOR MANUFACTURING COLOR FILTER, SOLID IMAGE PICKUP ELEMENT, AND INFRARED SENSOR

Номер: US20180057690A1

Автор: ARAYAMA Kyohei, Mori Masahiro, OOTA Kazuya, Shimada Kazuto, TAKISHITA Hirotaka, TSURUTA Takuya

Принадлежит: FUJIFILM Corporation

Provided is a coloring composition with which a film capable of allowing transmission of infrared light in a state where noise generated from visible light is small can be formed. In addition, also provided are a film, a color filter, a pattern forming method, a method for manufacturing a color filter, a solid image pickup element, and an infrared sensor in which the coloring composition is used. The coloring composition includes a coloring material that shields light in a visible range; and an infrared absorber. It is preferable that the coloring material that shields light in the visible range includes two or more chromatic colorants and that a combination of the two or more chromatic colorants forms black. Alternatively, it is preferable that the coloring material that shields light in the visible range includes an organic black colorant. It is preferable that the organic black colorant is at least one selected from the group consisting of a perylene compound and a bisbenzofuranone compound. 1. A coloring composition comprising:a coloring material that shields light in a visible range; andan infrared absorber.2. The coloring composition according to claim 1 ,wherein the coloring material that shields light in the visible range includes two or more chromatic colorants, anda combination of the two or more chromatic colorants forms black.3. The coloring composition according to claim 1 ,wherein the coloring material that shields light in the visible range includes an organic black colorant.4. The coloring composition according to claim 3 ,wherein the organic black colorant is at least one selected from the group consisting of a perylene compound and a bisbenzofuranone compound.5. The coloring composition according to claim 4 , further comprising:a chromatic colorant.6. The coloring composition according to claim 2 ,wherein the chromatic colorant is selected from the group consisting of a red colorant, a green colorant, a blue colorant, a yellow colorant, a violet ...

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Номер записи: 84

20-02-2020 дата публикации

IMPROVED SYNTHESIS OF NIR FLUORESCENT PROBE

Номер: US20200055855A1

Автор: BUONSANTI Federica, Crivellin Federico, FERRETTI Fulvio, Lattuada Luciano, MAISANO Federico, ORIO Laura, PIZZUTO Lorena

Принадлежит: BRACCO IMAGING SPA

The application relates to a process for the synthesis of a Near Infra-Red (NIR) fluorescent probe which is a cRGD-Cy5.5 conjugate of formula (I) known as DA364 comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions. 2. The process according to wherein the compound of formula (II) is dissolved in a solvent claim 1 , which solvent is an alcohol or a mixture of alcohols.3. The process according to wherein the compound of formula (II) is in a concentration of from 3 to 7 millimolar.4. The process according to wherein the step a) is performed by flowing the compound of formula (II) dissolved in a solvent through a metal catalyst under hydrogen atmosphere.5. The process according to wherein the step a) is carried out at a temperature of from 18° C. to 40° C.6. The process according to wherein the step b) is effected in the presence of a solvent selected from N claim 1 ,N-dimethylformamide claim 1 , N claim 1 ,N-dimethylacetamide claim 1 , dimethyl sulfoxide claim 1 , N-methylpyrrolidinone and acetonitrile.7. The process according to wherein the coupling reagent is selected from the group consisting of N claim 1 ,N claim 1 ,N claim 1 ,N′-tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate (TBTU) claim 1 , 4-(4 claim 1 ,6-dimethoxy-1 claim 1 ,3 claim 1 ,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) claim 1 , (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) claim 1 , (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) N claim 1 ,N claim 1 ,N claim 1 ,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (HATU) claim 1 , N claim 1 ,N claim 1 ,N claim 1 ,N′-tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate (HBTU) and propylphosphonic anhydride (T3P).8. The process according to wherein the base is selected from the group consisting of N claim 1 ,N-diisopropylethylamine (DIPEA) claim 1 , ...

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Номер записи: 85

04-03-2021 дата публикации

METHODS FOR DYE SELECTION FOR PROTEIN MELT TEMPERATURE DETERMINATIONS

Номер: US20210063405A1

Автор: BORNARTH Carole, RATH Mousumi

Принадлежит:

According to the present teachings, compositions, kits, and methods for protein melt analysis are provided that utilizing one or more fluorophore dyes. In some embodiments, a method comprises preparing a sample by mixing at least one protein with two or more dyes, and applying a controlled heating, while recording the fluorescence emission of the sample. The methods can be used, for example, for screening conditions for optimized protein stability, screening for ligands that bind and enhance protein stability (e.g., protein-protein interactions), screening for mutations for enhanced stability, screening crystallization conditions for protein stability, screening storage conditions for protein stability, and screening conditions in which a protein will be used (e.g., production conditions, treatment conditions, etc.) for protein stability. 118.-. (canceled)19. A composition comprising at least one protein , and a mixture of at least two fluorophore dyes , wherein each of the at least two fluorophore dyes is configured to provide at least a minimally fluorescent signal when the at least one protein is present in its native state and when the at least one protein is present in an unfolded state , then each of the at least two fluorophore dyes is configured to provide a substantially increased fluorescent signal.20. The composition of claim 19 , wherein one of the at least two fluorophore dyes is Nile Red.21. The composition of claim 19 , wherein one of the at least two fluorophore dyes is a styryl dye.23. The composition of claim 19 , wherein the at least one protein comprises a protein/ligand complex.24. The composition of claim 23 , wherein the protein/ligand complex is an antibody/antigen complex.25. The composition of claim 23 , wherein the ligand is a peptide claim 23 , a polynucleotide claim 23 , or an aptamer26. A kit comprising a composition comprising at least two fluorophore dyes claim 23 , wherein each of the at least two fluorophore dyes is configured to ...

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Номер записи: 86

02-03-2017 дата публикации

Compound for organic photoelectric device and organic photoelectric device image sensor, and electronic device including the same

Номер: US20170062726A1

Автор: Chang Duk YANG, Gyeongsik KIM, Yeong suk Choi, Yong Wan Jin, Yujin AHN

Принадлежит: SAMSUNG ELECTRONICS CO LTD, UNIST Academy Industry Research Corp

A compound for an organic photoelectric device includes at least one of a compound represented by Chemical Formula 1, a compound represented by Chemical Formula 2 and a combination thereof.

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Номер записи: 87

22-05-2014 дата публикации

Carbocyanines for G-Quadruplex DNA Stabilization and Telomerase Inhibition

Номер: US20140142147A1

Автор: Henary Maged, Wilson W. David

Принадлежит: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION

Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer. 1. A cyanine which selectively binds quadruplex DNA complexes.2. The cyanine of claim 1 , wherein the cyanine is a streptocyanine.3. The cyanine of claim 1 , wherein the cyanine is a hemicyanine.4. The cyanine of claim 1 , wherein the cyanine is a closed cyanine.5. The cyanine of claim 1 , wherein the cyanine is a symmetrical cyanine.6. The cyanine of claim 1 , wherein the cyanine is an asymmetrical cyanine.11. The cyanine of claim 10 , wherein the cyanine is:{'sub': 1', '2', '3', '2', '2', '2', '3', '3', '3', '2, 'sup': '+', '(a) R═H, R═H, R═CHCHCHN(CH), Z═C(CH);'}{'sub': 1', '1', '2', '3', '2', '2', '2', '3', '3', '3', '2, 'sup': '+', '(b) R═C, R═H, R═CHCHCHN(CH), Z═C(CH);'}{'sub': 1', '2', '3', '2', '2', '2', '3', '3', '3', '2, 'sup': '+', '(c) R=Br, R═H, R═CHCHCHN(CH), Z═C(CH);'}{'sub': 1', '2', '3', '2', '2', '2', '3', '3', '3', '2, 'sup': '+', '(d) R═I, R═H, R═CHCHCHN(CH), Z═C(CH);'}{'sub': 1', '2', '2', '3', '2', '2', '2', '3', '3', '2, 'sup': '−', '(e) R, R═—(CH═CH)—, R═CHCHCHSO, Z═C(CH);'}{'sub': 1', '2', '2', '3', '2', '2', '2', '2', '3', '3', '2, 'sup': '−', '(f) R, R═—(CH═CH)—, R═CHCHCHCHSO, Z═C(CH);'}{'sub': 1', '2', '3', '2 ...

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Номер записи: 88

28-02-2019 дата публикации

MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS

Номер: US20190062560A1

Автор: LI ZAIGUO, Pande Praveen, Raju Natarajan

Принадлежит: ENZO BIOCHEM, INC.

The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties. 2. The compound of claim 1 , wherein at least one of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , RR claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , Rand Rfurther comprises one or more reactive groups Z.3. The compound of claim 2 , wherein the reactive group comprises a nucleophilic reactive group claim 2 , an electrophilic reactive group claim 2 , a terminal alkene claim 2 , a terminal alkyne claim 2 , a coordinate group or an alkylating agent.4. The compound of claim 3 , wherein the nucleophilic reactive group is thiol claim 3 , amine or hydroxyl group.5. The compound of claim 3 , wherein the electrophilic reactive group is isocyanate claim 3 , isothiocyanate claim 3 , monochlorotriazine claim 3 , dichlorotriazine claim 3 , 4 claim 3 ,6-dichloro-1 claim 3 ,3 claim 3 ,5-triazines claim 3 , mono- or di-halogen substituted pyridine claim 3 , mono- or di-halogen substituted diazine claim 3 , maleimide claim 3 , haloacetamide claim 3 , aziridine claim 3 , sulfonyl halide claim 3 , acid halide claim 3 , hydroxysuccinimide ester claim 3 , hydroxysulfosuccinimide ester claim 3 , imido ester claim 3 , hydrazine claim 3 , azidonitrophenol claim 3 , imido ester claim 3 , hydrazine claim 3 , azide claim 3 , 3-(2-pyridyl dithio)-propionamide claim 3 , glyoxal claim 3 , or aldehyde.6. The compound of claim 1 , wherein the compound is linked to a target molecule.7. The compound of claim 6 , wherein the target ...

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Номер записи: 89

28-02-2019 дата публикации

POLYFUNCTIONAL POLYMERIZABLE COMPOUND AND COLORED COMPOSITION

Номер: US20190062561A1

Автор: KAWANO Kei, Takano Masahiro

Принадлежит:

With a colored composition of the related art, elution resistance within a practical range is not obtained. Therefore, an object of the present invention is to provide a colored composition having better elution resistance (less dye elution) than that of the colored composition of the related art. 2. The compound according to claim 1 ,{'sub': 3', '2', '3', '2, 'wherein in a case where Rin the general formula (2) is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, the number of the groups represented by the general formula (2) in Ain the general formula (1) is 2 to 6, or in a case where Rin the general formula (2) is the group represented by the general formula (2-1), the number of the groups represented by the general formula (2) in Ain the general formula (1) is 1 to 3.'}6. The compound according to claim 1 ,wherein Dye in the general formula (1) is a residue derived from a xanthene-based dye, a triarylmethane-based dye, or a cyanine-based dye.7. The compound according to claim 1 ,wherein Dye in the general formula (1) is a residue derived from the xanthene-based dye or the cyanine-based dye.10. A colored composition comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the compound according to .'}11. The colored composition according to claim 10 ,wherein the composition does not contain a cross-linking agent.12. The colored composition according to claim 10 , further comprising:a binder resin.13. The colored composition according to claim 12 ,wherein the binder resin is a binder resin having a polymerizable unsaturated group. The present invention relates to a polyfunctional polymerizable compound, which is used for forming colored pixels of color filters and the like and used in printing ink, ink jet ink, paint, and the like, and a colored composition comprising the compound.As color pixel forming methods used in manufacturing color filters of liquid crystal display elements, solid-state imaging devices, and the like, a staining method or a ...

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Номер записи: 90

27-02-2020 дата публикации

THERMAL TRANSFER SHEET, COATING LIQUID FOR COLORANT LAYER, METHOD FOR MANUFACTURING THERMAL TRANSFER SHEET, AND IMAGE FORMING METHOD

Номер: US20200062016A1

Автор: Hasegawa Hiroyuki, IMODA Tomohiko, Kobayashi Yoshimasa, Sakamoto Kano, SEGAWA Hiroaki, Suzuki Tomoko, Yoshida Kazuya

Принадлежит: Dai Nippon Printing Co., Ltd.

A thermal transfer sheet which can prevent a kick and a scumming, and can form a photographic tone color image of high quality with a continuous tone image by sublimation transfer; a coating liquid for colorant layer to be used for forming the colorant layer of this thermal transfer sheet; a method for manufacturing this thermal transfer sheet; and image forming method employing this thermal transfer sheet. The problem is solved by a thermal transfer sheet () in which at least a colorant layer () is layered on a substrate sheet (), wherein the colorant layer () contains a predetermined solvent, a colorant () dispersible in the predetermined solvent, a dispersant, and a binder resin, and the dispersant being one or more selected from the group consisting of polyether-based dispersants, graft type polymer dispersants, acryl-based block type polymer dispersants, urethane-based polymer dispersants and azo-based dispersants. 1. A thermal transfer sheet comprising:a substrate, a first colorant layer and a second colorant layer, layered in this order:the first colorant layer containing a first residual solvent, a sublimable dye soluble in the first residual solvent, and a first binder resin; andthe second colorant layer containing a second residual solvent, a colorant dispersible in the second residual solvent, and a second binder resin.2. A method of manufacturing a thermal transfer sheet comprising:a first colorant layer forming step of applying a coating liquid containing a first solvent, a sublimable dye soluble in the first solvent and a first binder resin, onto a surface of a substrate sheet to form a first colorant layer; anda second colorant layer forming step of applying a coating liquid containing a second solvent, a colorant dispersible in the second solvent and a second binder resin, onto the first colorant layer to form a second colorant layer. This application is a Divisional of U.S. application Ser. No. 15/680,411, filed Aug. 18, 2017, the entirety of which ...

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Номер записи: 91

17-03-2022 дата публикации

Encoded chromophoric polymer particles and methods of use thereof

Номер: US20220082566A1

Автор: Changfeng Wu, Daniel T. Chiu, Jiangbo Yu

Принадлежит: University of Washington Center for Commercialization

The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.

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Номер записи: 92

08-03-2018 дата публикации

AMPLICON MELTING ANALYSIS WITH SATURATION DYES

Номер: US20180066137A1

Автор: Dujols Virginie, Reed Gudrun, Wittwer Carl T., Zhou Luming

Принадлежит:

Methods are provided for nucleic acid analysis wherein a target nucleic acid that is at least partially double stranded is mixed with a dsDNA binding dye having a percent saturation of at least 50% to form a mixture. In one embodiment, the nucleic acid is amplified in the presence of the dsDNA binding dye, and in another embodiment a melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. Dyes for use in nucleic acid analysis and methods for making dyes are also provided. 124-. (canceled)25. A method for detecting the presence or absence of heteroduplex DNA in a sample , the method comprising:(a) mixing a target nucleic acid with a saturating dsDNA binding dye to form a target nucleic acid mixture,(b) amplifying the target nucleic acid mixture to generate an amplicon,(c) melting the amplicon while measuring fluorescence from the saturating dsDNA binding dye to generate a melting curve for the amplicon,(d) detecting the presence or absence of heteroduplex DNA by a shape of the melting curve that is indicative of the presence or absence of heteroduplex DNA.26. The method of claim 25 , further comprising:(e) denaturing the amplicon, and(f) renaturing the amplicon,wherein steps (e) and (f) occur prior to step (c).27. The method of claim 26 , wherein step (f) includes cooling at a rate of at least −2° C./s.28. The method of claim 27 , wherein step (c) includes heating at a rate of 0.2 to 0.4° C./s.29. The method of claim 26 , further comprising:prior to step (e), generating a second melting curve by melting the amplicon while measuring fluorescence from the saturating dsDNA binding dye, andsubsequent to step (c), comparing the melting curve to the second melting curve.30. The method of claim 25 , wherein the step (d) includesidentifying a first melting transition in the melting curve, andidentifying the presence or absence of a second melting transition in the melting curve, wherein the second ...

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Номер записи: 93

09-03-2017 дата публикации

Optical filter and imaging device

Номер: US20170066933A1

Автор: Hiroki Hotaka, Kazuhiko Shiono, Keigo Matsuura

Принадлежит: Asahi Glass Co Ltd

An optical filter includes an absorption layer containing a near-infrared absorbing dye with an absorption characteristic in dichloromethane satisfying (i-1) to (i-3). (i-1) In an absorption spectrum of a wavelength of 400 to 800 nm, there is a maximum absorption wavelength λ max in 670 to 730 nm. (i-2) Between a maximum absorption coefficient ∈ A of light with a wavelength of 430 to 550 nm and a maximum absorption coefficient ∈ B of light with a wavelength of 670 to 730 nm, the following relational expression: ∈ B /∈ A ≧65 is established. (i-3) In a spectral transmittance curve, the difference between a wavelength λ 80 with which the transmittance becomes 80% on a shorter wavelength side than the maximum absorption wavelength with the transmittance at the maximum absorption wavelength λ max set to 10% and the maximum absorption wavelength λ max is 65 nm or less.

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Номер записи: 94

12-03-2015 дата публикации

CYANINE DYES

Номер: US20150072894A1

Автор: Shen Gene, SUN Wei-Chuan (David), Yue Stephen

Принадлежит: Pacific Biosciences of California, Inc.

The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates. 127.-. (canceled)31. The cyanine compound of claim 28 , comprising at least one M moiety claim 28 , wherein the linker of this moiety comprises the structure C(O)NH(CH) claim 28 , wherein the index t is an integer selected from 1 claim 28 , 2 claim 28 , 3 claim 28 , 4 claim 28 , 5 claim 28 , 6 claim 28 , 7 claim 28 , 8 claim 28 , 9 claim 28 , 10 claim 28 , 11 claim 28 , and 12.32. The cyanine compound of claim 28 , comprising at least one M moiety claim 28 , wherein said linker of this moiety comprises a polyvalent scaffold.33. The cyanine compound according to claim 32 , wherein said polyvalent scaffold is a polyvalent arylene scaffold.34. The cyanine compound of claim 32 , wherein the polyvalent scaffold comprises a second cyanine moiety bound thereto claim 32 , said second cyanine moiety having a structure according to Formula I or Formula II.35. The cyanine compound of claim 28 , comprising at least one M claim 28 , wherein the linker comprises biotin bound to streptavidin.37. The cyanine compound according to claim 36 , wherein the linker moiety of the M moiety includes a —C(O)— moiety bound to a member selected from the alkyl moiety and the aryl ring to which the M moiety is bound.39. The cyanine compound according to claim 28 , having the formula:{'br': None, 'sup': 'D', 'sub': '2', 'M-(R)'} {'sup': 'D', 'each Rhas a structure independently selected from Formula I and Formula II.'}, 'wherein'}42. The cyanine compound according to claim 29 , having at least one Y moiety comprising a natural nucleobase.43. The cyanine compound according to claim ...

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Номер записи: 95

17-03-2016 дата публикации

PRINTING INK COMPOSITION

Номер: US20160075879A1

Автор: Ikeda Yasunari, Ito Akio

Принадлежит:

A printing ink composition includes a disperse dye, a surfactant, a water soluble dye, and a dispersant, in which an IOB value A of the disperse dye, an IOB value B of the surfactant, and an IOB value C of the water soluble dye satisfy the following Equation (1), A Подробнее

Номер записи: 96

16-03-2017 дата публикации

LATEX COMPRISING COLORANT AND METHODS OF MAKING THE SAME

Номер: US20170073499A1

Автор: Birau Mihaela Maria, Farrugia Valerie M.

Принадлежит:

A process includes forming an emulsion comprising a monomer and a colorant, the colorant further including an anionic functional group and a lipophilic counter ion, and polymerizing the monomer to form a latex, the latex includes polymer nanoparticles having the colorant dispersed therein. 1. A latex comprising copolymer nanoparticles having an organic colorant dispersed within a matrix of the copolymer nanoparticles , wherein the organic colorant comprises an anionic functional group and a lipophilic counter ion.2. The latex of claim 1 , wherein the copolymer nanoparticles comprise styrene-acrylate copolymer.3. The latex of claim 2 , wherein a ratio of styrene to acrylate is in a range from about 40:60 to 98:2.4. The latex of claim 1 , wherein the organic colorant comprises a modified pigment that comprises an indigo.5. The latex of claim 1 , wherein the organic colorant is covalently bound to the matrix of the copolymer nanoparticles.6. The latex of claim 1 , wherein the anionic functional group is selected from the group consisting of a sulfonate claim 1 , a sulfate claim 1 , a carboxylate claim 1 , a phosphate claim 1 , and combinations thereof.7. The latex of claim 1 , wherein the lipophilic counter ion is a quaternary ammonium counter ion.8. The latex of claim 7 , wherein the quaternary ammonium counter ion is a long chain aliphatic quaternary ammonium counter ion comprising at least one unsaturation of the carbon in the counter ion.9. The latex of claim 7 , wherein the quaternary ammonium counter ion is an esterquat.11. The latex of further comprising an additive selected from the group consisting of a crosslinker claim 1 , a charge control agent claim 1 , a chain transfer agent claim 1 , a surfactant claim 1 , and combinations thereof.12. The latex of claim 11 , wherein the surfactant is selected from the group consisting of anionic surfactants claim 11 , cationic surfactants claim 11 , nonionic surfactants and mixtures thereof.13. The latex of claim 12 , ...

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Номер записи: 97

18-03-2021 дата публикации

MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS

Номер: US20210079225A1

Автор: LI ZAIGUO, Pande Praveen, Raju Natarajan

Принадлежит: ENZO BIOCHEM, INC.

The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties. 2. A conjugate obtained by a process of reacting the compound of with a target molecule claim 1 , wherein said target molecule is a nucleoside claim 1 , a nucleotide claim 1 , an oligonucleotide claim 1 , a polynucleotide claim 1 , a peptide nucleic acid claim 1 , a protein claim 1 , a peptide claim 1 , an enzyme claim 1 , an antigen claim 1 , an antibody claim 1 , a hormone claim 1 , a hormone receptor claim 1 , a cellular receptor claim 1 , a lymphokine claim 1 , a cytokine claim 1 , a hapten claim 1 , a lectin claim 1 , avidin claim 1 , strepavidin claim 1 , digoxygenin claim 1 , a carbohydrate claim 1 , an oligosaccharide claim 1 , a polysaccharide claim 1 , a lipid claim 1 , or a glycolipid.3. The conjugate of claim 2 , wherein the target molecule is a nucleoside claim 2 , nucleotide claim 2 , oligonucleotide or polynucleotide.4. The conjugate of claim 2 , wherein the compound is linked to the target molecule by a linker arm.5. The compound of claim 1 , wherein each alkyl or alkoxy group independently comprises from 1-18 carbon atoms.6. The compound of claim 5 , wherein each alkyl or alkoxy group independently comprises from 1-6 carbon atoms.7. The compound of claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , Rand Rare each independently H claim 1 , a halogen claim 1 , an amino group claim 1 , a saturated or unsaturated claim 1 , linear or branched claim 1 , substituted or unsubstituted alkyl group claim 1 , a saturated or unsaturated claim 1 , linear or branched ...

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Номер записи: 98

22-03-2018 дата публикации

AZACYANINE DYES AND USE THEREOF

Номер: US20180079906A1

Автор: Dubikovskaya Elena A., Morales Morales Alma Rosa, Singh Rajendra, Sinisi Riccardo

Принадлежит: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging. 115-. (canceled)20. The dye according to claim 16 , wherein one of Rand Ris not aromatic in case of —NRRU; and one of Rand Ris not aromatic in case of —NRR; and one of Rand Ris not aromatic in case of —NRR; and one of Rand Ris not aromatic.21. The dye according to claim 16 , wherein R claim 16 , Rare independently of each other an alkyl group having from 1-8 carbon atoms.22. The dye according to claim 16 , wherein Ris in all cases independently selected from H and an alkyl group having from 1-8 carbon atoms.23. The dye according to claim 16 , having 1 claim 16 , 2 claim 16 , 3 or 4 linkers claim 16 , which are attached in the following positions: position R claim 16 , R claim 16 , or Rand R; in position R claim 16 , R claim 16 , or Rand R; or claim 16 , if the ring annulated to the pyrrol structure contains a N atom claim 16 , to this N atom.24. The dye according to claim 16 , having 1 or 2 linkers which are attached in the following positions: position R claim 16 , R claim 16 , or Rand R; in position R claim 16 , R claim 16 , or Rand R.25. The dye according to claim 16 , which is asymmetrical and does not have a C2 symmetry claim 16 , caused by different ring systems or by one or more substituents which are present only on one side of the molecule.27. A bioconjugate imaging agent according to claim 26 , wherein the targeting agents T are the same or different.28. A bioconjugate imaging agent according to claim 26 , linked to a biological target.29. A bioconjugate imaging agent according to claim 26 , linked to a biological target from the group transferrin claim 26 , proteins claim 26 , monoclonal ...

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Номер записи: 99

18-03-2021 дата публикации

Near-infrared absorbers, near-infrared absorbing/blocking films, photoelectric devices, organic sensors, and electronic devices

Номер: US20210083199A1

Автор: Bum Woo Park, Dong-seok Leem, Hwang Suk KIM, Hyesung Choi, Kwang Hee Lee, Ohkyu KWON, Takkyun RO

Принадлежит: SAMSUNG ELECTRONICS CO LTD

In Chemical Formula 1, X1, X2, Y1, Y2, Ar, Ar1, and Ar2 are the same as defined in the detailed description.

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Номер записи: 100

14-03-2019 дата публикации

COMPOSITION FOR NEAR-INFRARED LIGHT-ABSORBING FILMS, NEAR-INFRARED LIGHT-ABSORBING LAYERS, CAMERA MODULES, AND ELECTRONIC DEVICES

Номер: US20190079227A1

Автор: JUNG Myungsup, KIM Changki, KIM Hyung Jun, LEE Yong Joo, WON Jong Hoon

Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

A composition for a near-infrared light-absorbing film includes a binder, a compound represented by Chemical Formula 1, and a compound represented by Chemical Formula 2, wherein a total amount of the compound represented by Chemical Formula 1 and the compound represented by Chemical Formula 2 ranges from about 2.0 parts by weight to about 2.6 parts by weight based on 100 parts by weight of the binder. A near-infrared light-absorbing film may include a near-infrared light-absorbing layer including a cured product of the composition. A camera device may include the near-infrared light-absorbing film, and an electronic device may include the camera device. 2. The composition of claim 1 , whereinthe compound represented by Chemical Formula 1 is included in an amount of less than or equal to about 1.9 parts by weight based on 100 parts by weight of the binder, andthe compound represented by Chemical Formula 2 is included in an amount of less than or equal to about 0.7 parts by weight based on 100 parts by weight of the binder.3. The composition of claim 2 , whereinthe compound represented by Chemical Formula 1 is included in an amount of about 1.3 parts by weight to about 1.9 parts by weight based on 100 parts by weight of the binder, andthe compound represented by Chemical Formula 2 is included in an amount of about 0.1 parts by weight to about 0.7 parts by weight based on 100 parts by weight of the binder.4. The composition of claim 1 , wherein the composition further includes a cyanine-based dye claim 1 , a phthalocyanine-based dye claim 1 , a dithiolene metal complex dye claim 1 , or a diimmonium-based dye that have different structures from Chemical Formula 1.5. The composition of claim 1 , wherein the compound represented by Chemical Formula 1 and the compound represented by Chemical Formula 2 have independently an absorbance at a maximum absorption wavelength (λ) that is at least about 20 times as great as an absorbance at a wavelength of about 550 nm.6. The ...

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Номер записи: 101

14-03-2019 дата публикации

COMPOSITION FOR NEAR-INFRARED LIGHT-ABSORBING FILMS, NEAR-INFRARED LIGHT-ABSORBING LAYERS, CAMERA MODULES, AND ELECTRONIC DEVICES

Номер: US20190079228A1

Автор: JUNG Myungsup, KIM Changki, KIM Hyung Jun, LEE Yong Joo, WON Jong Hoon

Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

A composition for a near-infrared light-absorbing film includes a binder and compounds represented by separate particular chemical formulae. A near-infrared light-absorbing film may include a near-infrared light-absorbing layer including a cured product of the composition. A camera device may include the near-infrared light-absorbing film, and an electronic device may include the camera device. 2. The composition of claim 1 , wherein{'sub': 'max', 'the compound represented by Chemical Formula 1 has a maximum absorption wavelength (λ) within a wavelength spectrum of about 700 nm to about 800 nm, and'}{'sub': 'max', 'the compound represented by Chemical Formula 2 has a maximum absorption wavelength (λ) within a wavelength spectrum of about 800 nm to about 1200 nm.'}3. The composition of claim 1 , wherein the composition includes a first amount of the compound represented by Chemical Formula 1 and a second amount of the compound represented by Chemical Formula 2 claim 1 , the first amount equal to or less than the second amount.4. The composition of claim 3 , wherein the compound represented by Chemical Formula 1 and the compound represented by Chemical Formula 2 are included in the composition in a weight ratio of about 1:1 to about 1:3.5. The composition of claim 3 , wherein a total amount of the first amount and the second amount is an amount of about 0.2 parts by weight to about 5.0 parts by weight relative to 100 parts by weight of the binder.7. The composition of claim 1 , wherein{'sub': 'max', 'the compound represented by Chemical Formula 1 has an absorbance at a maximum absorption wavelength (λ) that is at least about 30 times as great as an absorbance of the compound represented by Chemical Formula 1 at a wavelength of about 550 nm, and'}{'sub': 'max', 'the compound represented by Chemical Formula 2 has an absorbance at a maximum absorption wavelength (λ) that is at least about 20 times as great as an absorbance of the compound represented by Chemical Formula ...

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Номер записи: 102