20-06-2013 дата публикации
Номер: US20130158010A1
Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1α) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia. Further disclosed are pharmaceutical compositions comprising HIF-1α prolyl hydroxylase inhibitors useful in treating diseases, conditions, and/or syndromes related thereto the activity of HIF-1α. 2. The method according to claim 1 , wherein L is CH.3. The method according to claim 1 , wherein L is SO.4. The method according to claim 1 , wherein each R is a substitution for hydrogen independently chosen from:{'sub': 1', '12', '3', '12', '3', '12, 'i) substituted or unsubstituted C-Clinear, C-Cbranched, or C-Ccyclic alkyl;'}{'sub': 1', '12', '3', '12', '3', '12, 'ii) substituted or unsubstituted C-Clinear, C-Cbranched, or C-Ccyclic alkenyl;'}{'sub': 2', '12', '3', '12, 'iii) substituted or unsubstituted C-Clinear or C-Cbranched alkynyl;'}{'sub': 6', '10, 'iv) Cor Csubstituted or unsubstituted aryl;'}{'sub': 1', '9, 'v) C-Csubstituted or unsubstituted heterocyclic;'}{'sub': 1', '11, 'vi) C-Csubstituted or unsubstituted heteroaryl;'}vii) halogen;{'sup': 23a', '23b', '10, 'sub': 'x', 'claim-text': [{'sup': '10', 'Ris chosen from, 'a) —H;', {'sub': 1', '12', '3', '12', '3', '12, 'b) substituted or unsubstituted C-Clinear, C-Cbranched, or C-Ccyclic alkyl;'}, {'sub': 6', '10, 'c) Cor Csubstituted or unsubstituted aryl or alkylenearyl;'}, {'sub': 1', '9, 'd) C-Csubstituted or unsubstituted heterocyclic;'}], 'viii) —[C(R)(R)]OR;'}{'sub': 1', '11, 'e) C-Csubstituted or unsubstituted heteroaryl;'}{'sup': 23a', '23b', '11a', '11b, 'sub': 'x', 'claim-text': [{'sup': 11a', '11b, 'Rand Rare each independently chosen from, 'a) —H;', {'sup': '12', 'claim-text': {'sup': '12', 'sub': 1', '4, 'Ris hydrogen or C-Clinear alkyl;'}, 'b) —OR;'}, {'sub': 1', '12', '3', '12', '3', '12, 'c) substituted or ...
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