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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 22782. Отображено 100.
05-01-2012 дата публикации

Observation apparatus

Номер: US20120002043A1
Автор: Nao Nitta
Принадлежит: Sony Corp

An observation apparatus includes a sample holder to hold a sample, a blade to cut the sample and subsequently form a new cross section, an optical system including a first objective lens and a second objective lens, and an electronic camera to capture an image of the cross section of the sample. A main controller causes the electronic camera to capture a partial image corresponding to a part of the cross section via the first objective lens. The main controller moves an XY stage to change relative positions of the sample and the optical system within an XY plane, to thereby acquire a plurality of partial images. An image processing unit generates synthesized image data obtained by synthesizing the partial images for each cross section to display it on a display unit. Accordingly, a user can observe a high-resolution image.

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20-11-2016 дата публикации

Держатель лезвия микротома

Номер: RU0000166223U1

Держатель лезвия микротома, содержащий основание, неподвижно зафиксированные на нем ограничительные планки, установленную между ними с помощью винтов подпружиненную прижимную планку, под передней частью которой фиксируется лезвие, и прижимной механизм, воздействующий на заднюю часть прижимной планки, причем передняя часть основания и прижимной планки скошены под острым углом, а прижимной механизм выполнен в виде эксцентриковой оси, снабженной поворотной ручкой, вынесенной за пределы основания, отличающийся тем, что на основании выполнен направляющий выступ, входящий в паз прижимной планки, причем передняя часть прижимной планки выполнена под углом 25-27° с поднутрением нижней части 2°, а передняя часть основания шириной 7 мм выполнена под углом 15-18°. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 166 223 U1 (51) МПК G01N 1/06 (2006.01) B26B 5/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ТИТУЛЬНЫЙ (21)(22) Заявка: ЛИСТ ОПИСАНИЯ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ 2016102933/05, 29.01.2016 (24) Дата начала отсчета срока действия патента: 29.01.2016 (72) Автор(ы): Цимберг Владимир Викторович (RU) (73) Патентообладатель(и): Общество с ограниченной ответственностью "ЭргоПродакшн" (RU) R U Приоритет(ы): (22) Дата подачи заявки: 29.01.2016 (45) Опубликовано: 20.11.2016 Бюл. № 32 1 6 6 2 2 3 R U (57) Формула полезной модели Держатель лезвия микротома, содержащий основание, неподвижно зафиксированные на нем ограничительные планки, установленную между ними с помощью винтов подпружиненную прижимную планку, под передней частью которой фиксируется лезвие, и прижимной механизм, воздействующий на заднюю часть прижимной планки, причем передняя часть основания и прижимной планки скошены под острым углом, а прижимной механизм выполнен в виде эксцентриковой оси, снабженной поворотной ручкой, вынесенной за пределы основания, отличающийся тем, что на основании выполнен направляющий выступ, входящий в паз прижимной планки, причем передняя часть прижимной планки выполнена под ...

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30-10-2018 дата публикации

Устройство для отбора проб воды

Номер: RU0000184551U1

Полезная модель относиться к области отбора проб и может быть использована при отборе проб воды из скважин, колодцев и подледных водоемов для последующего химического, микробиологического и геохимического анализов. Устройство для отбора проб воды, включающее сосуд, связанный гибким звеном с грузоподъемным механизмом, цилиндрический водозаборник из нержавеющей стали, нижняя часть которого изготовлена в виде стакана, а верхняя часть - сужающейся горловины, лебедку с ручным приводом и телескопической треногой, грузонесущим металлическим тросом и двумя карабинами, содержит запорный механизм, включающий скобу удерживающую, серьгу качающуюся, втулку регулировочную с резьбой, пружину возвратную, шток, шайбу стопорную, вертлюг, пробку силиконовую, карабин, фал и кронштейн, установленный в верхней части с внутренней стороны телескопической треноги, при этом скоба удерживающая приварена к горловине с раструбом, а верхняя часть раструба уже стакана. Преимуществом устройства являются возможность обеспечения достоверного пробоотбора подземных вод из скважин с заданной глубины и слоев без смешения пробы воды из других горизонтов, возможность применения при различных исследованиях, эффективность в работе на разных типах наблюдательных скважин, простота изготовления, невысокая стоимость, компактность конструкции, удобство в эксплуатации и обслуживании. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 184 551 U1 (51) МПК G01N 1/10 (2006.01) G01N 1/02 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК G01N 1/10 (2018.05); G01N 1/02 (2018.05) (21)(22) Заявка: 2018121675, 13.06.2018 (24) Дата начала отсчета срока действия патента: Дата регистрации: 30.10.2018 (45) Опубликовано: 30.10.2018 Бюл. № 31 1 8 4 5 5 1 R U (54) УСТРОЙСТВО ДЛЯ ОТБОРА ПРОБ ВОДЫ (57) Реферат: Полезная модель относиться к области отбора проб и может быть использована при отборе проб воды из скважин, колодцев и подледных водоемов для последующего химического, ...

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27-10-2021 дата публикации

Устройство для безопасного отбора с заданных глубин проб грунта, включая многолетнемерзлые породы

Номер: RU0000207417U1

Полезная модель относится к устройствам для безопасного бурения почвы, включая многолетнемерзлые породы, и может быть использована для безопасного отбора различных почвенных образцов в полевых условиях для проведения лабораторных исследований, как для научных целей, так и для оценки земель технологического назначения. Техническим результатом заявляемой полезной модели является высокая безопасность извлечения и исследования пробы грунта, а также повышение качества конечных результатов исследования отобранной пробы, снижение трудоемкости отбора пробы, универсальность и оперативность за счет компактности и мобильности заявляемой полезной модели. Устройство включает цилиндрическую трубу бура, которая содержит по всей длине с двух противоположных сторон направляющих стенок несколько сквозных отверстий, центры которых расположены на заданном расстоянии друг от друга и совпадают с центрами отверстий на противоположной направляющей стенке, на верхнем торце трубы установлена технологическая заглушка, а на нижнем торце - расположен резец, труба бура погружается и вынимается из грунта через термоблок с газовой горелкой, тепловым экраном и сборником зольного остатка. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 207 417 U1 (51) МПК E02D 1/04 (2006.01) G01N 1/08 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК E02D 1/04 (2021.02); G01N 1/08 (2021.02) (21)(22) Заявка: 2020143448, 25.12.2020 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): Акционерное общество "ЦНИИ "Электрон" (RU) Дата регистрации: 27.10.2021 (45) Опубликовано: 27.10.2021 Бюл. № 30 2 0 7 4 1 7 R U (54) Устройство для безопасного отбора с заданных глубин проб грунта, включая многолетнемерзлые породы (57) Реферат: Полезная модель относится к устройствам для за счет компактности и мобильности заявляемой безопасного бурения почвы, включая полезной модели. Устройство включает многолетнемерзлые породы, и может быть цилиндрическую трубу ...

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01-03-2012 дата публикации

Method and System for Extracting Samples After Patterning of Microstructure Devices

Номер: US20120052601A1
Принадлежит: Globalfoundries Inc

Analysis of chemical and physical characteristics of polymer species and etch residues caused in critical plasma-assisted etch processes for patterning material layers in semiconductor devices may be accomplished by removing at least a portion of these species on the basis of a probing material layer, which may be lifted-off from the patterned surface. The probing material layer may substantially suppress a chemical modification of the species of interest and may thus allow the examination of the initial status of these species.

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29-03-2012 дата публикации

Slide-type core retainer for sample collector

Номер: US20120073875A1

A slide-type core retainer for a sample collector including a sampler tube driven into a sea floor. The slide-type core retainer includes a catcher holder detachably coupled to a tip end of the sampler tube; a catcher installed on an inner peripheral surface of a tip end of the catcher holder and configured to allow sediment introduction into the sampler tube and preventing sediment from being lost using resiliency. A control member slidably installed inside the catcher holder controls opening and closing of the catcher. The control member is coupled to the catcher before sample collection so that the catcher remains opened. The control member slides into an inner side of the catcher holder while being separated from the catcher by the resistance of the solid sediment such that the catcher is closed, when resistance is generated by solid sediment after the sampler tube is driven into the sediment.

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31-05-2012 дата публикации

Detection of a component of interest with an ultraviolet laser and method of using the same

Номер: US20120135537A1

Means and method for analysis of a component of interest in a sample is provided. A small sample cell is provided which decreased dispersion of the sample. Also provided is a device for detection of a component of interest in a sample in which the small sample cell is used with an ultra violet laser in which the energy of the laser is spread over an area such that energy density is above desorption threshold, but the sample not ablated. Rapid and reliable detection of a component of interest is provided with the invention.

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21-06-2012 дата публикации

System and method for identification of biological tissues

Номер: US20120156712A1
Автор: Zoltan Takats
Принадлежит: Medimass Kft

The present invention provides for a system, method, and device for analyzing, localizing and/or identifying tissue types. The method includes analyzing, localizing and/or identifying one or more tissue samples, characterized in that the method comprises: (a) generating gaseous tissue particles from a site in the one or more tissue samples, (b) transporting the gaseous tissue particles from the site to an analyser, (c) using the analyser for generating tissue-related data based on the gaseous tissue particles, and (d) analyzing, localizing and/or identifying the one or more tissue samples based on the tissue-related data. The invention can either be used in close conjunction with a surgical procedure, when one or more surgical tools are an integrated part of ionization, or as a separate mass spectrometric probe for the analysis of one or more tissue parts.

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05-07-2012 дата публикации

Cryostat having an illumination device

Номер: US20120170256A1
Автор: Claudia Dorenkamp
Принадлежит: LEICA BIOSYSTEMS NUSSLOCH GMBH

The present invention relaters to a cryostat ( 1 ) having a cryostat chamber ( 2 ) containing a microtome ( 3 ) for cutting frozen specimens, and further containing an illumination device ( 4 ) for illuminating the cryostat chamber ( 2 ); the illumination device ( 4 ) providing safelight illumination.

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30-08-2012 дата публикации

Evidence collector with integral quantified reagents and method of modulating specimen drying time

Номер: US20120220042A1
Автор: Jangbir Sangha
Принадлежит: Individual

Apparatus and methods are provided for evidence specimen collection having integral reagent holders to hold reagent vials and having drying agent or desiccant holding areas that permit the renewal of the desiccant and permit the introduction of variously size desiccant qualities to allow modulation of the specimen drying time to achieve early stabilization of specimens while holding the specimen in an isolated drying area during storage and shipment and for simultaneous collection of multiple evidence samples with simultaneous storage, drying, marking, evidence security and shipping provided and with the provision for simultaneous storage, drying, marking, evidence security and shipping provided for a control specimen.

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06-09-2012 дата публикации

Device for Determining Particle Sizes

Номер: US20120224166A1
Автор: Martin Heine, Stefan Manz
Принадлежит: BUEHLER AG

Method for measuring particle size distributions, in particular for the optical measurement of wide particle size distributions of bulk materials such as cereals, cereal milling products, cereal products and the like, which is intended to enable the measurement of particle size distributions which vary by orders of magnitude. To address this problem, a sample of isolated particles is optically detected in an arrangement by means of at least two measurement methods, wherein preferably detection of the contours of the particles and laser diffraction take place at the same time.

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27-09-2012 дата публикации

Microtome with surface orientation sensor to sense orientation of surface of sample

Номер: US20120240737A1
Принадлежит: Sakura Finetek USA Inc

A sample sectioning device includes a cutting mechanism, a sample holder, a drive system, and a surface orientation sensor. The sample holder is operable to hold a sample. The cutting mechanism is operable to cut sections from the sample. The drive system is coupled with the sample holder. The drive system is operable to drive movement between the sample held by the sample holder and the cutting mechanism. The surface orientation sensor is operable to sense an orientation of a surface of the sample held by the sample holder.

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25-10-2012 дата публикации

Sanitary swab collection system, microfluidic assay device, and methods for diagnostic assays

Номер: US20120271127A1
Принадлежит: Micronics Inc

Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.

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21-03-2013 дата публикации

Rapid analyte collection and testing device

Номер: US20130068040A1
Принадлежит: Individual

A rapid analyte collection and testing device, said device comprising a) a casing, said casing having) a first casing section, said first casing section containing an encapsulated buffer section containing a buffer, and asecond casing section, said second casing section comprising a window on a side of said second section, a complementary mechanism for attachment to said first casing section, an opening at a proximal end of said second casing section; and a non permeable platform strip positioned lengthwise within and extending beyond the second casing section. The non-permeable platform further contains a swab, said swab positioned at the distal end of said non-permeable platform strip, a lateral flow assay positioned downstream from said swab, and a tag, positioned upstream from the capture reagent site.

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28-03-2013 дата публикации

Method And Devices For The Cross-Referencing Of Identification Of Tissue Slice Supports For Microtomised Analytical Samples

Номер: US20130078669A1
Автор: Hans L. Heid, Jose Novoa
Принадлежит: MICROM INTERNATIONAL GMBH

The invention relates to a method and device for the cross-referencing of identification ( 1 ) of tissue slice supports ( 2 ), for microtomised analytical samples still to be mounted thereon, with identification information ( 3 ) of a tissue sample holder ( 4 ) of a tissue sample ( 5 ) which is not yet microtomised. The conventional problem of cross-referencing is improved in a simple manner, whereby the identification information ( 3 ) for the tissue sample holder ( 4 ) is automatically detected when positioned in the microtome ( 6 ) and an identification ( 1 ) corresponding thereto is automatically transferred to at least one tissue slice support ( 2 ) and that tissue slice support ( 2 ), provided with the identification ( 1 ), is dispensed for application of the tissue sample slice at the moment when a tissue sample slice must be applied to a tissue slice support ( 2 ).

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18-04-2013 дата публикации

Hand-held trace vapor/particle sampling system

Номер: US20130091963A1
Автор: Jack A. Syage
Принадлежит: Morpho Detection LLC

A sampling system that contains filter components for collecting and concentrating vapor and particles in high-volume flows. The sample is then vaporized and delivered to a detector at a low-volume flow. The invention also has a sampling probe that contains an air-jet to help dislodge particles from surfaces and a heating lamp to help vaporize compounds on surfaces or objects. The sampling system is especially useful for screening for explosives and other illicit chemicals and toxins on people, baggage, cargo, and other objects.

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02-05-2013 дата публикации

AUTOMATIC SAMPLER FOR GRANULATION COATING APPARATUS

Номер: US20130104673A1
Принадлежит: FREUND CORPORATION

In a pan coating apparatus provided with a rotating drum, a sampling portion is provided at a leading end portion of a sampling pipe extending inside and outside the rotating drum. The sampling portion swings between a pickup position A and a suction position D within the drum. The sampling portion introduces objects to be processed in the sampling portion, and then the objects are scooped out while moving the sampling portion to the suction position B. Thereafter, the objects are sucked by an ejector and fed to a sample collecting portion. 1. An automatic sampler mounted to a granulation coating apparatus that performs processings such as granulation , coating , drying and mixing of powder and particle in a processing vessel provided therein , the sampler comprising:a sampling pipe that has one end disposed in the processing vessel and the other end extending outside the processing vessel;a sampling portion that is formed at a leading end of the one end of the sampling pipe and moves in the processing vessel so as to pickup a sample of objects to be processed from a layer of the object to be processed of the powder and particle;a depressurization source that imparts sample suction action brought about by depressurization to the sampling pipe;a sample collecting portion that is provided between the other end of the sampling pipe and depressurization source and accommodates the sample of the objects to be processed sucked from the sampling portion; andan air return pipe that has one end connected to the depressurization source and the other end communicating with an inside of the processing vessel and circulates exhaust air caused by the sample suction action into the processing vessel.2. The automatic sampler according to claim 1 , whereinthe sampling portion is formed so as to be bent at the leading end of the sampling pipe and inclined relative to a horizontal axis.3. The automatic sampler according to claim 1 , whereinthe sampling portion swings between a pickup ...

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09-05-2013 дата публикации

TISSUE ARRAY PRODUCTION METHOD

Номер: US20130115652A1
Принадлежит:

A tissue array production method which enables even roll-shaped tissue pieces having various diameters to be steadily fixed to a substrate block is provided. 1. A tissue array production method , wherein roll-shaped tissue pieces formed by rolling sheet-like tissue pieces in the shape of a roll are arranged on a substrate in an array form , the method comprising the steps of:placing a holding member which holds a plurality of roll-shaped tissue pieces so that their axis directions are vertically directed in a container into which a melted embedding medium is poured for its accumulation, to hold the respective roll-shaped tissue pieces in the holding member;pouring the embedding medium into the container, to form a substrate block constituted so that the plurality of roll-shaped tissue pieces is arranged in the array form; andslicing the substrate block so that the roll-shaped tissue pieces are ring-shaped, to place the sliced pieces on the substrate.2. The tissue array production method according to claim 1 , wherein the embedding medium is a paraffin.3. The tissue array production method according to claim 1 , wherein an elastic member including a plurality of insertion holes having at least the same diameters as the minimum diameter of the roll-shaped tissue piece is used as said holding member claim 1 , to hold the outer periphery of the roll-shaped tissue piece.4. The tissue array production method according to claim 3 , wherein said insertion hole is polygonal.5. The tissue array production method according to claim 1 , wherein a grid-like member including a plurality of grid squares with at least the same side length as the minimum diameter of the roll-shaped tissue piece is used as said holding member claim 1 , to hold the outer periphery of the roll-shaped tissue piece.6. The tissue at production method according to claim 1 , wherein bar-like holding members to be inserted into the axial cores of the plurality or roll-shaped tissue pieces are used as said ...

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09-05-2013 дата публикации

Sample collection tool

Номер: US20130116596A1
Принадлежит: DNA Genotek Inc

A sample collection tool comprises a collection end configured for collecting a sample. Optionally, the sample is collected from within a body cavity of an animal without causing significant discomfort or injury to the animal. A first handle portion has a first end connected to the collection end and a second end. A second handle portion is connected to the second end of the first handle portion by a breakable connection. The second end of the first handle portion has at least one winglet. The at least one winglet is compliant in a preferential direction. The breakable connection is ruptured at least in part when the at least one winglet is forced in the preferential direction.

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16-05-2013 дата публикации

Motor driven rotational sampling apparatus with removable cutting tools for material collection

Номер: US20130118017A1
Автор: Joel S. Harris
Принадлежит: GE Healthcare Bio Sciences Corp

A motorized apparatus to simultaneously excise, retrieve, temporarily store and transport a sample of material has a hollow clamshell casing with a blended contoured grip for the fingers, a horizontal extension to eliminate slippage when held in a user's hand, and a flange bottom portion from which a removable cutting tool threaded to a drive shaft extends downwards. Within the clamshell casing an electric motor is mounted which drives, via gears, a drive shaft which rotates a cutting tool threaded to the distal end of the drive shaft. The end of the cutting tool, distal from the clamshell casing, forms a cutting edge circumscribing a circular region. An ejection rod slides reciprocally within the cutting tool between a stowed position and an expulsion position. Users core a sample from the source material by engaging contact between the cutting edge of the cutting tool and the surface of the source material, applying pressure against the surface of the source material while simultaneously activating the motor to rotate the cutting tool. The cutting region of the cutting tool passes through the source material contacting the support surface below the source material which urges the cored sample into the lumen of the cutting tool. The sample may be stored in the lumen or transported. Activation of the ejection rod moves from the stowed position towards the expulsion position displacing the temporarily stored sample from the lumen space in the cutting tool into the appropriate collection receptacle or onto a desired surface.

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16-05-2013 дата публикации

Trace evidence collection method

Номер: US20130118276A1
Автор: Duval Joelle N.
Принадлежит:

A method of collecting trace evidence comprises covering a surface with a sheet material comprising a sheet of material having a first side and a second side. The first side comprises an active side exhibiting an adhesion peel force after activation by a user which is greater than an adhesion peel force exhibited prior to activation by a user and which is sufficient to adhere to a target surface. The sheet of material is sufficiently flexible to conform readily to a desired surface and has sufficiently small resiliency that it does not exert undue restorative forces which would tend to cause the sheet of material to break contact with the desired surface. The sheet material is pressed on the target surface. The sheet material is removed from the surface wherein trace evidence adheres to the sheet material. 1. A method of collecting trace evidence comprising:covering a surface with a sheet material comprising a sheet of material having a first side and a second side, said first side comprising an active side exhibiting an adhesion peel force after activation by a user which is greater than an adhesion peel force exhibited prior to activation by a user and which is sufficient to adhere to a target surface, said sheet of material being sufficiently flexible to conform readily to a desired surface and having sufficiently small resiliency that it does not exert undue restorative forces which would tend to cause said sheet of material to break contact with such a desired surface;pressing the sheet material on the target surface;removing the sheet material from the surface;wherein trace evidence adheres to the sheet material; andcovering the sheet material with a transparent film.2. The method of wherein the sheet of material is non-porous.3. The method of wherein the sheet material is pressure sensitive.4. The method of wherein the sheet material is clingless.5. The method of further comprising removing the transparent film.6. The method of further comprising analyzing ...

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30-05-2013 дата публикации

THERMOPHORETIC SAMPLER

Номер: US20130133441A1
Принадлежит:

A thermophoretic sampler includes a sample assembly into which a removable sample cartridge can be inserted. The sample cartridge holds a substrate that, upon insertion, is exposed to a sample chamber. Thermophoresis is induced in the sample chamber, causing nanoparticles to be deposited on the substrate. 1. A thermophoretic sampling device , the device comprising:a sample chamber defining a portion of a flow path for air;a substrate having a collection surface exposed to a first region of the sample chamber;a first thermal conduction element that is thermally coupled to the substrate; anda thermoelectric cooler that is thermally coupled to the thermal conduction element.2. The device of claim 1 , wherein the thermoelectric cooler comprises a first surface and a second surface claim 1 , wherein the first surface of the thermoelectric cooler contacts a first surface of the first thermal conduction element and claim 1 , wherein the second surface of the thermoelectric cooler contacts a heat dispersion mechanism.3. The device of claim 2 , the heat dispersion mechanism comprising at least one of a thermally conductive housing and a heat sink.4. The device of claim 1 , further comprising:a second thermal conduction element having a first surface and a second surface, wherein the first surface of the second thermal conduction element is exposed to a second region of the sample chamber; anda heating element having a surface that contacts the second surface of the second thermal conduction element.5. The device of claim 1 , wherein at least a portion of the sample chamber is bounded by an inside surface of a tube portion claim 1 , wherein a first end of the tube portion is adapted to be coupled to an inlet of an active sampling aerosol monitor.6. The device of claim 1 , further comprising:a sample core assembly, wherein the sample chamber is defined within the sample core assembly;a cartridge port, the cartridge port comprising an opening defined in an outside surface of ...

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20-06-2013 дата публикации

Sample holder with plunger and method for expelling sample

Номер: US20130152710A1
Принадлежит: Covaris LLC

Method and apparatus for holding and/or transferring a sample material into a second holder. The sample holder may comprise a shoulder arranged on the outer surface to engage a second holder and to position a top opening of the sample holder for communication with the second holder. A sample may be expelled from a sample holder using a piston that moves from a lower portion to an upper portion of the sample holder.

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27-06-2013 дата публикации

METHOD AND DEVICE FOR TAKING A SAMPLE IN A STEAM GENERATOR

Номер: US20130160267A1
Автор: SEEBERGER ERICH
Принадлежит: AREVA NP GMBH

A method takes a sample of a deposit on a secondary side of a pipe base plate of a steam generator of a nuclear power plant, In the method a steam generator pipe is removed from the pipe base plate to expose a hot pipe bore penetrating the pipe base plate. A removal tool of a device for taking the sample is introduced into the hot pipe bore by the primary side of the pipe base plate which is opposite the secondary side. A part of the deposit is removed by the removal tool as the sample. The sample is transported and removed from the steam generator. The removal tool is removed from the steam generator. The device contains the removal tool which can be introduced by a primary side of the pipe base plate in an exposed hot pipe bore penetrating the pipe base plate for removing the sample. 1. A method for taking a sample of a deposit on a secondary side of a pipe base plate of a steam generator of a nuclear power plant , which comprises the steps of:removing a steam generator pipe from the pipe base plate for exposing a hot pipe bore which penetrates the pipe base plate;introducing a removal tool of a device for taking the sample into the hot pipe bore from a primary side of the pipe base plate being disposed opposite the secondary side;mechanically removing part of the deposit by way of the removal tool as the sample;in an assembled state, rotating the removal tool about a drive axis extending parallel to a center longitudinal axis of the hot pipe bore for removing the sample;adjusting the drive axis with reference to the center longitudinal axis in a radial direction and is advanced in a circumferential direction for removing the sample;conveying the sample through the hot pipe bore to the primary side and the sample is removed out of the steam generator; andremoving the removal tool out of the steam generator.2. The method according to claim 1 , which further comprises fixing a carrier of the device in the hot pipe bore claim 1 , and moving the removal tool in ...

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04-07-2013 дата публикации

Fluid flow sampling device

Номер: US20130167666A1
Принадлежит: Universal Analyzers Inc

A fluid flow sampling device comprises an elongate housing and a sleeve disposed in the housing having openings corresponding to an inlet and an outlet of the housing. The sleeve is movable relative to the housing to an open position and a closed position. The open position aligns the openings of the sleeve with the inlet and the outlet to allow fluid to flow into the inlet, through the sleeve, and out of the outlet. The closed position blocks the inlet and/or the outlet with a portion of the sleeve such that fluid is prevented from flowing through the sleeve. Additionally, a coalescent filter is disposed in the sleeve between the inlet and the outlet to allow some fluid to pass through the filter for sampling and to allow another portion of fluid to flow past the filter and out of the outlet to carry away coalescent material on the filter.

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18-07-2013 дата публикации

Interactive and automated tissue image analysis with global training database and variable-abstraction processing in cytological specimen classification and laser capture microdissection applications

Номер: US20130182922A1
Автор: David H. Kil
Принадлежит: Life Technologies Corp

A system and method for performing tissue image analysis and region of interest identification for further processing applications such as laser capture microdissection is provided. The invention provides three-stage processing with flexible state transition that allows image recognition to be performed at an appropriate level of abstraction. The three stages include processing at one or more than one of the pixel, subimage and object levels of processing. Also, the invention provides both an interactive mode and a high-throughput batch mode which employs training files generated automatically.

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25-07-2013 дата публикации

CUTTING STROKE ADJUSTMENT OF A ROTARY MICROTOME

Номер: US20130186248A1
Автор: Heid Hans Ludwig
Принадлежит:

A rotary microtome () for producing thin sections for histology is used for specimens () of different sizes. To maintain optimized cutting conditions, an adaptation to different specimen sizes is required without incurring disadvantages in terms of operation. An adjustment possibility is provided for the length of the vertical cutting movement (). However, the moment that is generated by the vertical carriage () and that acts on the drive shaft () then changes. To maintain balanced moments of the drive movement, the counterweight has to be accordingly adapted by an adjustment weight (). For this purpose, means are provided which, in an ergonomic and effective manner, permit the adjustment of the cutting stroke and also the necessary adaptation of the counterweights in one operation step. The rotary microtome according to the invention is suitable in particular in a histological routine in which mixed specimens are present in standard cassettes and also in macro-cassettes and in which, therefore, a rapid change of the cutting stroke length is desired along with good balance of the drive movement. 11712101131. A rotary microtome () with a vertical carriage () performing the cutting stroke , a driving shaft () for generating the vertical cutting movement () , a cutting stroke adjustment unit of the cutting stroke and with a counterweight (′) and an adjustment weight () with adjustable compensation mass ,{'b': 12', '22', '12', '30', '12', '34', '12', '32', '31', '12', '3', '30', '12', '22', '34', '7', '18', '19', '12', '20', '21', '11', '31', '19, 'the microtome comprising, that the driving shaft () is formed as a hollow shaft which has an opening on its lateral surface, that a crank pin adjustment unit () is connected on the down-force side of the driving shaft (), that a control element () is located in extension of the opposite ending of the driving shaft (), that a weight adjustment unit () is placed on the segment between the two endings of the driving shaft (), ...

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01-08-2013 дата публикации

TISSUE CASSETTE ASSEMBLY

Номер: US20130196371A1
Принадлежит:

A tissue cassette includes a body having a first floor and a first perimeter wall encircling and extending from the first floor so that the first floor and first perimeter wall at least partially bound a body cavity, the first floor having a plurality of spaced apart openings extending therethrough. A mold has a second floor and a second perimeter wall encircling and extending from the second floor so that the second floor and second perimeter wall at least partially bound a mold cavity, the second floor having at least one micropore extending therethrough, the at least one micropore having a maximum diameter less than 0.040 inches. A hinge couples the body to the mold so that the body and mold can move between a closed position wherein the first floor overlies the second floor so as to form a tissue compartment therebetween and an open position. 1. A tissue cassette comprising:a body comprising a first floor and a first perimeter wall encircling and extending from the first floor so that the first floor and first perimeter wall at least partially bound a body cavity, the first floor having a plurality of spaced apart openings extending therethrough;a mold comprising a second floor and a second perimeter wall encircling and extending from the second floor so that the second floor and second perimeter wall at least partially bound a mold cavity, the second floor having at least one micropore extending therethrough, the at least one micropore having a maximum diameter less than 0.040 inches; anda hinge coupling the body to the mold so that the body and mold can move between a closed position wherein the first floor overlies the second floor so as to form a tissue compartment therebetween and a open position.2. The tissue cassette as recited in claim 1 , wherein the at least one micropore has a diameter less than 0.040 inches.3. The tissue cassette as recited in claim 1 , wherein the at least one micropore comprises a plurality of spaced apart micropores in a range ...

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15-08-2013 дата публикации

Device for Collection of Materials from Surfaces

Номер: US20130205921A1

A device for collecting material from a solid surface, and optionally concentrating the collected material, for subsequent analysis includes a nebulizer that generates and discharges a fluid stream, and a collector positioned to intercept material caused by the fluid stream after it is deflected from the solid surface. The device is usable in a sample collection process having steps of spraying a fluid stream of gas containing nebulized solvent as the solid surface, positioning a collector to intercept material carried by the fluid. The process may be repeated to concentrate the material being sampled. 1. A process for collecting a sample of a material distributed over a solid surface comprising:spraying a fluid stream of a gas containing a nebulized solvent at a solid surface on which a material is distributed to cause removal of the material from the solid surface and entrainment of the material by the fluid stream;positioning a collector surface to intercept the material entrained b y the fluid stream deflected from the solid surface; andoptionally repeating the spraying and positioning steps for one or more different areas of the solid surface to concentrate material on the collector surface.2. A process for collecting a sample of a material distributed over a solid surface and analyzing the material , comprising:spraying a fluid stream of a gas containing a nebulized solvent at a solid surface area on which a material is distributed to cause desorption of the material from the solid surface and entrainment of the material by the fluid stream;positioning a collector surface to intercept the desorbed material carried by the fluid stream deflected from the solid surface;optionally repeating the spraying and positioning steps for one or more different areas of the solid surface to concentrate material on the collector surface;removing the material from the collector surface; andemploying a conventional analytical technique to detect, identify and/or quantify the ...

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22-08-2013 дата публикации

ISOTHERMAL SUBSEA SAMPLING SYSTEM AND METHOD

Номер: US20130213149A1
Принадлежит:

A system and method for collecting a selected phase of a representative sample from a multiphase fluid flowing through a flowline, preferably located subsea. The system includes a multiphase sampling apparatus attachable to the flowline for sampling the representative sample; a vehicle sampling apparatus (e.g., ROV) locatable proximate the flowline having a power supply and a fluid sample collector for storing at least one selected phase of the representative sample; an interface for connecting the multiphase sampling apparatus and the vehicle sampling apparatus; and a temperature control arrangement disposed between the multiphase sampling apparatus and the vehicle sampling apparatus configured to minimize the temperature difference between the representative sample and the multiphase fluid flowing through the flowline. 1. A system for collecting the at least one selected phase of a representative sample from a multiphase fluid flowing through a flowline , the system comprising:a multiphase sampling apparatus attachable to a flowline for sampling a representative sample of a multiphase fluid flowing through the flowline;a vehicle sampling apparatus locatable proximate the flowline, the vehicle sampling apparatus comprising a power supply and a fluid sample collector for storing the at least one selected phase of the representative sample;an interface for connecting the multiphase sampling apparatus and the vehicle sampling apparatus; anda temperature control arrangement disposed between the multiphase sampling apparatus and the vehicle sampling apparatus that minimizes the temperature difference between the representative sample and the multiphase fluid flowing through the flowline, the temperature control arrangement configured to receive power from the vehicle sampling apparatus.2. The system of claim 1 , which is locatable subsea.3. The system of claim 2 , wherein the vehicle sampling apparatus is a subsea remotely operated vehicle (ROV).4. The system of claim 3 ...

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29-08-2013 дата публикации

APPARATUS AND METHOD FOR TAKING SAMPLES

Номер: US20130220036A1
Автор: Faust Horst
Принадлежит: FLSMIDTH A/S

The invention relates to a device () for sampling, comprising a housing () having a housing chamber () which has two connection openings () for connecting one line portion in each case. The device () includes a withdrawal element () which is movable in the housing chamber (). The withdrawal element is formed, at least in portions, in a profile-like manner, and bounds a hollow sampling region (), extending along a profile longitudinal direction course (), at the periphery of the sampling region, while leaving an entry opening () which extends along an opening longitudinal direction course (). Guide means are provided by means of which a defined movement pattern of the withdrawal element () in the housing chamber () is predetermined, via which movement pattern at least one of the two opening cross-sections () in a projection view perpendicular thereto may be traversed over the entire area by means of the entry opening (). The invention proposes that as a result of the movement pattern specified by the guide means, an orientation of the withdrawal element () in an observation plane which moves with the withdrawal element relative to a geometric intersection line of the observation plane with a nonmoving geometric reference plane which extends perpendicular to the observation plane and to at least one opening cross-section (), remains the same when the withdrawal element () is moved. 1. A device for sampling , in particular for withdrawing samples from free-flowing and/or liquid and/or gaseous material , comprising a housing having a housing chamber which has two connection openings , spaced apart from one another , for connecting in each case a line portion through which a material flow may flow , the two connection openings in particular having identical opening cross-sections , andthe device including a withdrawal element which is movable in the housing chamber,the withdrawal element being formed, at least in portions, in a profile-like manner, the withdrawal element ...

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19-09-2013 дата публикации

Automated Seed Sampler and Methods of Sampling, Testing and Bulking Seeds

Номер: US20130244321A1
Автор: Deppermann Kevin L.
Принадлежит: MONSANTO TECHNOLOGY LLC

An automated system for sampling seeds generally includes an automated sampling station having a seed feeder and a seed sampler. The seed feeder is configured to deliver seeds to the seed sampler, and the seed sampler is configured to remove material from the seeds without substantially adversely affecting the germination viability of the sampled seeds. The system also includes a sample handling station configured to receive the material removed from the seeds, and a seed handling station configured to receive the sampled seeds after the material is removed from the seeds such that the relationship between the material removed from the seeds and the respective seeds can be determined. 1. An automated system for sampling seeds , the system comprising:an automated sampling station having a seed feeder and a seed sampler, the seed feeder configured to deliver seeds to the seed sampler, and the seed sampler configured to remove material from the seeds without substantially adversely affecting the germination viability of the sampled seeds;a sample handling station configured to receive the material removed from the seeds; anda seed handling station configured to receive the sampled seeds from the sampling station after the material is removed from the seeds such that the relationship between the material removed from the seeds and the respective seeds can be determined.2. The system of claim 1 , wherein the seed handling station includes a seed tray and wherein the sample handling station includes a sample tray claim 1 , the system further comprising:a table supporting the seed tray and the sample tray; andan index mechanism operable to move the table to bring the seed tray into position for receiving from the sampling station the seeds from which the material is removed, and to bring the sample tray into position for receiving the material removed from the seeds.3. The system of claim 2 , further comprising:a sample transport system configured to transport the material ...

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26-09-2013 дата публикации

Method for Sampling Jointed Rock Mass

Номер: US20130247693A1
Автор: Liu Ning, ZHANG Chunsheng

The present disclosure relates to a method for sampling rock mass, especially jointed rock mass. The present disclosure provides a simple and convenient method for sampling jointed rock mass to prevent the rock sample from being disturbed and damaged during sampling and accordingly resulting in opening of the weak structural planes, to therefore obtain rock specimen correctly reflecting the basic physical and mechanical characteristics of rock mass comprising integral fissure network. The method for sampling jointed rock mass of the present disclosure comprises the following steps: Step a: Siting; Step b: Drilling; Step c: Protecting; and Step d: Sampling. The method is suitable for determining the basic mechanical properties of the rock mass and for assessing the stability of caverns in jointed rock mass. 1. A method for sampling jointed rock mass comprising the following steps:a. selecting a sampling position and removing a surface layer of the rock mass till intact rock mass is exposed;b. drilling at the selected position with an overcore to form a columnar rock sample which is connected to the rock mass only at a bottom of the rock sample, and at the same time filling water into a 5 mm wide cylindrical trepanning between the rock sample and its surrounding rock masses;c. heating a prefabricated transparent cylindrical PVC film sleeve with a wall thickness of 3 mm and an inner diameter slightly less than an outer diameter of the rock sample so as to make the sleeve expand, and covering the rock sample with the sleeve; andd. removing the rock mass around the rock sample after the sleeve is cooled such that the rock sample is exposed, applying one or more ring protectors on a surface of the sleeve, covering a top portion of the rock sample with plastic foam, and separating the rock sample from the rock mass.21. The method according to claim 1 , wherein in the water filling process of step b claim 1 , the rock sample () is kept under a hydrostatic pressure state ...

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26-09-2013 дата публикации

Method of preparing biological specimen

Номер: US20130250090A1
Автор: Nobuhiko Morimoto
Принадлежит: Olympus Corp

A sufficient amount of biological molecules are collected from a desired region in a tissue section with a single operation. Provided is a method of preparing a biological specimen including a sectioning step of sectioning biological tissue along a single cutting plane; a staining step of staining a first tissue section of two tissue sections that have been sectioned in the sectioning step; a stained-image capturing step of acquiring a stained image of the stained tissue section; a non-stained-image capturing step of acquiring a non-stained image in which, with respect to a second tissue section that has been sectioned in the sectioning step, division lines that divide the tissue section into a plurality of segments are defined; and associating steps of associating the non-stained image and the stained image with each other.

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03-10-2013 дата публикации

Apparatus for inspecting filler in container, apparatus for filling filler, and method for inspecting filler in container

Номер: US20130255832A1
Автор: Toyokazu Uchida
Принадлежит: Mitsubishi Heavy Industries Ltd

A container filler-inspecting apparatus includes a weight-measuring unit ( 14 ) that measures the weight of the container ( 1 ) filled with a filler (S 1 ), a sample-extracting unit ( 12 ) that extracts a fixed amount of filler (S 1 ) from a tip opening ( 2 ) of the container ( 1 ), and a sampling unit ( 13 ) that performs a sampling operation by wiping off the filler extracted by the sample-extracting unit ( 12 ) with a sampling paper sheet.

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24-10-2013 дата публикации

PROCESS OF FABRICATING TISSUE ARRAY

Номер: US20130281322A1
Автор: FUKUOKA Junya
Принадлежит:

In a process of fabricating a tissue array, a tissue block is sliced to obtain sheet-form pieces of tissue, and each of the sheet-form pieces is closely rolled around a guide member to form a spiral shape tissue around the guide member. Then, the spiral shape tissues are inserted in an axial direction into holes arrayed in a base block. 1. A process of fabricating a tissue array , comprising:a step of slicing a tissue block to obtain sheet-form pieces of tissue,a step of rolling each of the sheet-form pieces closely around a guide member to form a spiral shape tissue around the guide member, anda step of inserting the spiral shape tissues in an axial direction into holes arrayed in a base block.2. A process of fabricating a tissue array according to claim 1 , further comprising a step of cutting the spiral shape tissues to have a predetermined length in the axial direction claim 1 , before or after the step of inserting the spiral shape tissue into the base block.3. A process of fabricating a tissue array according to claim 1 , further comprising a step of slicing the tissue array in the base block in a direction perpendicular to the axial direction to have a spiral shape in cross section.4. A process of fabricating a tissue array according to claim 1 , wherein the tissue block is retained in paraffin claim 1 , and the tissue block with the paraffin is sliced in the slicing step. This is a divisional application of Ser. No. 12/449,865 filed on Oct. 20, 2009, which is based on PCT/JP2008/053965 filed on Mar. 5, 2008 claiming a priority of Japanese Patent Application No. 2007-056884 filed on Mar. 7, 2007.The present invention relates to a process of fabricating a tissue array.A tissue array chip having pieces of tissue disposed on a substrate has heretofore been used for the examination or analysis of body tissue. The tissue array chip is used for the examination of presence or absence of diseased tissue, the analysis of a gene or protein, screening, etc. through ...

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31-10-2013 дата публикации

DEVICE FOR STRETCHING SAMPLE SECTIONS

Номер: US20130287649A1
Принадлежит: Leica Microsystems CMS GmbH

The present invention relates to a glass plate () for use in a device () for stretching sample sections having a sectioning knife, the glass plate () being arranged at the back () of the sectioning knife in such a way that a defined gap () for reception of the sectioned sample is formed between the back () of the sectioning knife and the plate (), the glass plate () possessing, at least on one of its longitudinal sides (), edges () ground and polished to optical flatness. 12123432. A glass plate () for use in a device () for stretching sample sections having a sectioning knife , the glass plate () being arranged at a back () of the sectioning knife in such a way that a defined gap () for reception of a sample section is formed between the back () of the sectioning knife and the plate () ,{'b': 2', '21', '22', '211', '212', '221', '222, 'wherein the glass plate () possesses, at least on one of its longitudinal sides (, ), edges (, ; , ) ground and polished to optical flatness, having an optical flatness better than λ/2 and/or a roughness <5 nm RMS.'}222112122212222122. The glass plate according to claim 1 , wherein the glass plate () possesses edges ( claim 1 , ; claim 1 , ) ground and polished to optical flatness on two oppositely located longitudinal sides ( claim 1 , ).32. The glass plate according to claim 1 , wherein the glass plate () is hardened by thermal stress introduction.4223. The glass plate according to claim 1 , wherein the glass plate () has a protective layer () acting as a diffusion barrier.5224. The glass plate according to claim 1 , wherein the glass plate () is finished with a reflection-reducing layer ().61. A device () for stretching sample sections claim 1 , the device comprising:{'b': '3', 'a sectioning knife having a back ();'}{'b': 2', '3', '4', '3', '2, 'a glass plate () arranged at the back () of the sectioning knife in such a way that a defined gap () for reception of a sample section is formed between the back () of the sectioning knife ...

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07-11-2013 дата публикации

Surface sampling concentration and reaction probe

Номер: US20130294971A1
Принадлежит: UT Battelle LLC

A method of analyzing a chemical composition of a specimen is described. The method can include providing a probe comprising an outer capillary tube and an inner capillary tube disposed co-axially within the outer capillary tube, where the inner and outer capillary tubes define a solvent capillary and a sampling capillary in fluid communication with one another at a distal end of the probe; contacting a target site on a surface of a specimen with a solvent in fluid communication with the probe; maintaining a plug volume proximate a solvent-specimen interface, wherein the plug volume is in fluid communication with the probe; draining plug sampling fluid from the plug volume through the sampling capillary; and analyzing a chemical composition of the plug sampling fluid with an analytical instrument. A system for performing the method is also described.

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21-11-2013 дата публикации

METHOD OF CUTTING AT LEAST ONE THIN SECTION AND TAGGING AT LEAST ONE SPECIMEN SLIDE

Номер: US20130309717A1
Принадлежит:

A method of cutting at least one thin section from a sample block that is arranged in a cassette and tagging at least one specimen slide such that it can be allocated to the specific sample block from which the thin section has been cut. The method includes removing a cassette from a cassette magazine; reading the machine-readable coded information of the cassette identifier; generating by at least one tagging unit a specimen slide identifier that interrelates to the cassette identifier read by the reading unit; inserting the cassette into a microtome; transferring data from the microtome to a tagging unit via a data transfer path while the cassette is inserted into the microtome; enabling tagging of the specimen slide; tagging the specimen slide by the tagging unit; and cutting the thin section and transferring it onto the specimen slide that was tagged by the tagging unit. 1. A method of cutting at least one thin section from a sample block that is arranged in a cassette and tagging at least one specimen slide such that it can be allocated to the specific sample block from which the thin section has been cut , said method comprising:removing a cassette from a cassette magazine by a removal unit, said cassette having a cassette identifier having at least one machine-readable coded information;reading the machine-readable coded information of the cassette identifier of the cassette by at least one reading unit at a point in time of one of before, during, and after removal of the cassette from the cassette magazine;generating by at least one tagging unit a specimen slide identifier that interrelates to the cassette identifier read by the reading unit, said tagging unit generating an at least machine-readable coded information for identification of the specimen slide;inserting the cassette into a microtome;transferring data from the microtome to a tagging unit via a data transfer path while the cassette is inserted into the microtome;enabling tagging of the specimen ...

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21-11-2013 дата публикации

APPARATUS FOR REMOVAL OF SPECIFIC SEED TISSUE OR STRUCTURE FOR SEED ANALYSIS

Номер: US20130309764A1
Автор: Cope Jason
Принадлежит: PIONEER HI-BRED INTERNATIONAL, INC.

An apparatus for reducing resources for selecting seed to be produced in commercial quantities or for research is disclosed. Samples of seed which are candidates for selection are collected and given an identifier. Specific tissue or structure from candidate seed is removed. A test or analysis is performed on the candidate seed or the removed tissue or structure. Results of the test or analysis are recorded and correlated to the seed's identifier. The results are evaluated and a decision is made whether to select a candidate seed for commercial production or for research. Time, space, and labor associated with growing plants in an experimental plot or greenhouse and taking tissue samples from growing plants is saved. 1. An apparatus for conducting laser ablation on a seed comprising:a. a seed holder; andb. the seed holder having surfaces which minimize non-diffusive laser reflection.2. The apparatus of wherein the seed holder comprises a well or cavity defined by a bottom and a sidewall claim 1 , and further comprising a conical counter sunk bottom for centering the seed in the well or cavity.3. The apparatus of further comprising a plurality of wells or cavities in an array of indexable rows and columns.4. The apparatus of wherein the well or cavity is formed in a metal material.5. The apparatus of wherein the metal is aluminum.6. The apparatus of wherein the well or cavity in the aluminum is painted claim 5 , powder coated claim 5 , sand blasted claim 5 , or anodized.7. The apparatus of wherein the well or cavity has a diameter which is greater than the longest dimension of the seed.8. The apparatus of wherein the well or cavity is adapted to receive a single seed.9. The apparatus of wherein the well or cavity is defined by a bottom and sidewall formed of plastic claim 2 , rubber claim 2 , paper claim 2 , cardboard claim 2 , composite material claim 2 , or other substantially rigid material.10. An apparatus for resource-efficient selection of seed for production ...

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28-11-2013 дата публикации

METHOD AND DEVICE FOR REMOVING A SAMPLE FROM A COIL

Номер: US20130312544A1
Принадлежит: Sms Siemag AG

The present invention relates to a device () for removing a sample () from a coil (), comprising at least one bottom roll unit () for supporting the coil () during removal of the samples, at least one contact roll unit () pressable against an outer surface of the coil (), and at least one strip binding device for binding the coil () supported on the at least one bottom roll unit (). The present invention further relates to a device for removing a sample () from a coil (), comprising a deflection device () for deflecting a material beginning () of the coil () from a beneath located layer (), wherein the deflection device is so formed that the strip beginning only elastically deflected from the beneath layer (). The invention also relates to corresponding methods. 11242303224042223032. A device () for removing a sample () from a coil () , comprising at least one bottom roll unit ( , ) for supporting the coil () during removal of the sample; at least one contact roll unit ( , ) pressable against an outer surface of the coil (); and at least one strip binding device for binding the coil () supported on the at least one bottom roll unit ( , ).2343032444042. A device according to claim 2 , wherein rolls () of the bottom roll unit ( claim 2 , ) and/or rolls () of the contact roll unit ( claim 2 , ) have recesses for displacing therethrough of a strip binding material and/or for forming a strip binding channel.334303244404264. A device according to claim 1 , wherein rolls () of the bottom roll unit ( claim 1 , ) and/or rolls () of the contact roll unit ( claim 1 , ) have claim 1 , respectively claim 1 , at least two roll units so that a strip binding material () is displaceable between separate roll elements and/or a strip binding channel is formed therebetween.4422. A device according to claim 1 , wherein at least one second contact roll unit () is provided which is pressable against the outer surface of the coil ().53032. A device according to claim 1 , wherein at least ...

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12-12-2013 дата публикации

Self Contained Sampling and Processing Facility

Номер: US20130327159A1
Принадлежит: LEWIS AUSTRALIA PTY LTD

A self-contained mobile sampling and processing facility for use at a mine having at least one blast-hole that forms a blast-hole cone wherein the sampling and processing facility includes at least one primary robotic arm that carries at least one sampling tool, and the primary robotic arm and sampling tool is controlled by robotic arm and sampling tool movement controller means, and the primary robotic arm is capable of self-determining the direction, distance and shape of a nearby blast-hole cone, then subsequently positioning itself so that the sampling tool is able to engage with the blast-hole cone and retrieve a sample from it without significant mixing or stirring the cone, or a localised region of the cone, and then the sample is deposited into the processing facility. 1. A self-contained mobile sampling and processing facility for use at a mine having at least one blast-hole that forms a blast-hole cone wherein the sampling and processing facility includes at least one primary robotic arm that carries at least one sampling tool , and the primary robotic arm and sampling tool is controlled by robotic arm and sampling tool movement controller means , and the primary robotic arm is capable of self-determining the direction , distance and shape of a nearby blast-hole cone , then subsequently positioning itself so that the sampling tool is able to engage with the blast-hole cone and retrieve a sample from it without significant mixing or stirring the cone , or a localised region of the cone , and then the sample is deposited into the processing facility.2. The self-contained mobile sampling and processing facility as claimed in wherein the robotic arm and sampling tool movement controller means are automatic that rely on sensors including camera(s) claim 1 , and/or distance sensor(s) claim 1 , and/or manual control means by an operator.3. The self-contained mobile sampling and processing facility as claimed in wherein at least one primary robotic arm is carried ...

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12-12-2013 дата публикации

SOLID SUPPORT AND METHOD OF ENHANCING THE RECOVERY OF BIOLOGICAL MATERIAL THEREFROM

Номер: US20130330750A1
Принадлежит: GE Healthcare UK Limited

The present invention relates to solid supports that are used for the storage and further processing of biological materials. The invention is particularly concerned with solid supports which have at least one surface coated with a chemical that enhances the recovery of the biological material from the support. Methods of preparing and using the solid supports are also described. 1. A method of recovering a biological material from a solid support having at least one surface coated with a chemical selected from the group consisting of polyvinyl pyrrolidone (PVP) , poly-2-ethyl-2-oxazoline (PEOX) , comprising the steps of:i) contacting a surface of a solid support with a sample containing a biological material;ii) drying said sample on said surface of said support;iii) storing the support; andiv) extracting said biological material from the surface.2. The method of claim 1 , wherein said solid support is selected from the group consisting of paper claim 1 , glass microfiber and membrane.3. The method of claim 19 , wherein said paper is a cellulose paper.4. The method of claim 2 , wherein said membrane is selected from the group consisting of polyester claim 2 , polyether sulfone (PES) claim 2 , polyamide (Nylon) claim 2 , polypropylene claim 2 , polytetrafluoroethylene (PTFE) claim 2 , polycarbonate claim 2 , cellulose nitrate claim 2 , cellulose acetate and aluminium oxide.58-. (canceled)9. The method of claim 1 , wherein step iii) comprises storing the solid support at a temperature in the range of 15 to 40° C.10. The method of wherein the sample is selected from the group consisting of tissue claim 1 , cell claim 1 , blood claim 1 , plasma claim 1 , saliva and urine.11. The method of claim 1 , wherein said biological material is selected from the group consisting of biomolecule claim 1 , synthetically-derived biomolecule claim 1 , cellular component and biopharmaceutical drug.12. The method of claim 1 , wherein said biological material is a biopharmaceutical drug. ...

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19-12-2013 дата публикации

LIQUID CHROMATOGRAPH, SAMPLE INTRODUCTION DEVICE FOR LIQUID CHROMATOGRAPH, AND METHOD FOR CLEANING SAMPLE INTRODUCTION DEVICE FOR LIQUID CHROMATOGRAPH

Номер: US20130333452A1
Принадлежит:

Disclosed is a liquid chromatograph provided with: a first flow path switching means which switches between connection of a sample storage loop to a mobile phase flow path and separation of the sample storage loop from the mobile phase flow path; a needle which suctions and discharges a sample; a weighing means which performs suction and discharge of the sample to the needle while weighing the sample; a cleaning solution feeding means which feeds a cleaning solution; a second flow path switching means which switches between at least two types of cleaning solutions; a third flow path switching means which switches between connection of the needle and the weighing means and connection of the needle and the cleaning solution feeding means; and a control means which controls operation of the first flow path switching means, the weighing means, the cleaning solution feeding means, the second flow path switching means, and the third flow path switching means, wherein the total amount of the sample is injected into the sample storage loop and the cleaning solution is injected into a flow path from the sample storage loop to a sample inlet. 1. A liquid chromatograph comprising ,a first flow passage switching means including a sample storage loop to switch the sample storage loop between a connection thereof to a flow passage of a mobile phase and a disconnection thereof from the flow passage of the mobile phase,a needle for sucking and discharging a sample,a metering means for performing sucking of the sample into the needle and discharging the sample while metrizing the sample,a washing solution feeding means transferring a washing solution,a second flow passage switching means switching at least two kinds of the washing solution,a third flow passage switching means performing switching between a connection between the needle and the metering means and a connection between the needle and the washing solution feeding means, anda control means controlling operations of the ...

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02-01-2014 дата публикации

Sample collection and bioluminescent analysis system

Номер: US20140004548A1
Принадлежит: BioControl Systems Inc

Methods and apparatus for evaluating the quality of an environment or process by measuring light emitted from a bioluminescent sample containing ATP, ADP, or alkaline phosphatase. The apparatus comprises a sample collection and analysis system used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The system includes an instrument having a photon detection assembly for use with the sample testing device and one or more probe assemblies that optically cooperate with the instrument. The instrument includes a dark chamber with a reflective interior surface which may be concave or preferably spherical, and a photon detection sensor such as a multi-pixel photon counter sensor. A substantially transparent portion of the probe assembly, and liquid contained therein, focus bioluminescence toward the photon detection sensor.

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16-01-2014 дата публикации

FORMING AN ELECTRON MICROSCOPE SAMPLE FROM HIGH-PRESSURE FROZEN MATERIAL

Номер: US20140014834A1
Принадлежит:

A method of forming a sample from a capillary with high-pressure frozen sample material comprises providing a high-pressure capillary with vitrified sample material at a temperature Tbelow the glass transition temperature T, cutting the capillary, warming the capillary to a temperature Tbetween temperature Tand temperature T, cooling the capillary to a temperature Tbelow temperature T, as a result of which material is extruded from the capillary, and freeing a sample from the extruded sample material at a temperature below temperature T. Repeating this temperature cycle results in further extrusion of the sample material. The extruded material can then be sliced by, for example, ion beam milling. 1. Method of forming a sample from a capillary with high-pressure frozen sample material , the method comprising:{'sub': 1', 'g, 'providing a high-pressure capillary with vitrified sample material at a temperature Tbelow the glass transition temperature T,'}cutting the capillary,{'sub': 2', '1', 'g, 'warming the capillary to a temperature Tbetween temperature Tand temperature T,'}{'sub': 3', '2, 'cooling the capillary to a temperature Tbelow temperature T, as a result of which material is extruded from the capillary, and'}{'sub': 'g', 'freeing a sample from the extruded sample material at a temperature below temperature T.'}2. The method of in which cooling the capillary to a temperature Tbelow temperature Tcomprises immersing the capillary in a liquid with a temperature below temperature T.3. The method of in which the capillary is a metal capillary.4. The method of in which the metal comprises copper and/or iron and/or aluminium.5. The method of in which the difference between temperature Tand Tis more than 20 K.6. The method of in which freeing a sample comprises cutting with a focused ion beam.7. The method of in which the freed sample is a lamella.8. The method of in which the method further comprises inspection of the freed sample in an electron microscope.9. The ...

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16-01-2014 дата публикации

Liquid Sampling, Storage, Transfer and Delivery Device

Номер: US20140018701A1
Принадлежит: Porex Corporation

The present invention provides a liquid sampling, storage, transfer and delivery device comprising housing containing a porous nib. The porous nib in the device contacts the sample, collects the sample, stores the sample, transports the sample inside its porous matrix and releases the sample from the porous matrix upon demand. 127.-. (canceled)28. A device for liquid sample collection comprising:a porous nib configured to collect a liquid sample; and,a housing configured to support the porous nib.29. The device of claim 28 , wherein the housing comprises a system for advancing and retracting the porous nib through an opening in the housing.30. The device of claim 28 , further comprising a cap.31. The device of claim 28 , wherein the porous nib comprises a nib tip and a nib stem.32. The device of claim 28 , wherein the porous nib comprises plastic claim 28 , metal claim 28 , glass claim 28 , or ceramic.33. The device of claim 32 , wherein the porous plastic nib comprises polyethylene claim 32 , polypropylene claim 32 , polyvinylidene fluoride claim 32 , polyamide claim 32 , polyacrylate claim 32 , polyacrylic nitrile claim 32 , ethylene-vinyl acetate claim 32 , polyester claim 32 , polycarbonate claim 32 , polystyrene claim 32 , polytetrafluoroethylene claim 32 , or cellulose claim 32 , or a combination thereof.34. The device of claim 33 , wherein the porous plastic nib comprises polyethylene and the polyethylene is high density polyethylene claim 33 , low density polyethylene claim 33 , or ultra high molecular weight polyethylene claim 33 , or a combination thereof.35. The device of claim 28 , wherein the device is in a shape of a pen.36. The device of claim 28 , wherein the porous nib comprises one or more preset markers that allow the porous nib to break into segments.37. The device of claim 28 , wherein the housing further comprises a reservoir.38. The device of claim 28 , wherein the device may be connected to a mass spectrometer so that the porous nib is in ...

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23-01-2014 дата публикации

Automated contamination-free seed sampler and methods of sampling, testing and bulking seeds

Номер: US20140020287A1
Принадлежит: MONSANTO TECHNOLOGY LLC

An automated seed sampler system includes an imaging device for obtaining images of seeds, an orienting device for orienting the seeds based on the images, and a sampling station for removing tissue from the oriented seeds. In some aspects, the system also includes a transport subsystem for supporting the oriented seeds and conveying the oriented seeds to the sampling station. A method for removing tissue from seeds includes imaging the seeds, orienting the seeds based on image information obtained from the seeds, and removing tissue from the oriented seeds. In some aspects, the method also includes transporting the oriented seeds in a transport subsystem to a sampling station for removing the tissue from the oriented seeds, and/or collecting the tissue removed from the oriented seeds so that a one-to-one correspondence exists between the tissue and the sampled seeds, and/or analyzing the tissue for characteristics indicative of genetic and/or chemical traits.

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30-01-2014 дата публикации

SAMPLE SPLITTER

Номер: US20140026684A1
Принадлежит:

A device for splitting a sample, in particular a time-inhomogeneous sample, into two or more representative fractional samples, as well as a sample taking system with a sample splitter and a sample taker, wherein the sample splitter has a first pump () with a first flow rate and at least one second pump () with a second flow rate, wherein the first pump and the at least one second pump () co-act, so that the inhomogeneous sample on its passage through a conduit system () is at the same time split up into at least two representative fractional samples. 1. A device for splitting a sample , in particular a time-inhomogeneous sample , into two or more fractional samples , the device comprising:a sample chamber with an inlet through which the inhomogeneous sample is received;a first pump having a first flow rate;a second pump having a second flow rate, configured for bidirectional operation; anda conduit system, having at least one conduit and at least one outlet, the at least one conduit connected to the sample chamber, the first pump and the second pump, so that the respective pumps, operating in a co-acting manner, move the sample from the sample chamber, split the sample into two or more representative factional samples and deliver the two or more factional samples to at least one of the at least one outlets.2. The device of claim 1 , wherein:the first pump is configured for unidirectional operation.3. The device of claim 2 , wherein:the first and second flow rates are different.4. The device of claim 2 , wherein:the first and second flow rates are the same.5. The device of claim 2 , wherein: a first conduit, arranged between the first pump and the sample chamber;', 'a second conduit, arranged between the sample chamber and the at least one outlet; and', 'a third conduit, arranged between the second pump and the at least one outlet., 'the at least one conduit of the conduit system comprises6. The device of claim 5 , wherein:the conduits have uniform cross-sectional ...

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30-01-2014 дата публикации

Microtome having a piezoelectric linear actuator

Номер: US20140026727A1
Автор: Roland Walter
Принадлежит: LEICA BIOSYSTEMS NUSSLOCH GMBH

The present invention relates to a microtome ( 10 ) for cutting thin sections, including a sample holder ( 12 ), a cutting unit ( 16 ), and a drive unit ( 16 ) for producing a feed movement between the sample holder ( 12 ) and the cutting unit ( 16 ) for setting the thickness of the sample sections. The drive unit ( 22 ) includes a piezoelectric linear actuator ( 50 ) for producing the feed movement.

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30-01-2014 дата публикации

Microtome having an auto-rocking mode

Номер: US20140026728A1
Автор: Roland Walter
Принадлежит: LEICA BIOSYSTEMS NUSSLOCH GMBH

The present invention relates to a microtome ( 10 ) including a sample holder ( 12 ) a cutting unit ( 16 ), and a drive unit ( 22 ) capable of producing a relative movement between the sample holder ( 12 ) and the cutting unit ( 16 ) for cutting the sample. In addition, the microtome ( 10 ) has a handwheel ( 32 ) and an encoder ( 38 ). A control unit ( 40 ) controls the drive unit ( 22 ) as a function of the rotational movement of the handhweel ( 32 ) detected by the encoder ( 38 ) and in such a way that, in a first operating mode, the relative movement produced between the sample holder ( 12 ) and the cutting element ( 16 ) by the drive unit ( 22 ) when the handwheel ( 32 ) is rotated through a full revolution has a maximum first stroke length and that, in a second operating mode, the relative movement has a preset second stroke length shorter than the maximum first stroke length.

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30-01-2014 дата публикации

Reagent impregnated swipe for chemical detection

Номер: US20140030816A1
Принадлежит: Massachusetts Institute of Technology

The invention is directed to a swipe with at least one ionization reagent associated with the swipe for detecting target analytes and methods of detecting the target analyte molecules that can indicate the presence of, for example, explosives, narcotics, chemical warfare agents, biological warfare agents, or toxins. The swipe can be used to transfer molecules from a surface to the swipe for further analysis. In particular, the swipes can include an ionization reagent that is preferably a low volatility compound and capable of forming ionization reagent-analyte complexes with target analytes. The swipe can also include multiple ionization reagents with different volatilities such that they are released sequentially during a thermal ramp-up. Alternatively, the swipe can have multiple ionization reagents associated with spatially separated portions of the swipe such that they can be releasable sequentially to detect multiple target analytes.

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06-02-2014 дата публикации

SOLID PHASE MICRO EXTRACTION (SPME) VACUUM INLET

Номер: US20140033835A1
Принадлежит:

A sample introduction system configured for introducing analytes of a solid phase micro extraction (SPME) sample into an analytical instrument system (e.g., mass spectrometer) is described. The sample introduction system includes a pressure vessel configured with an inlet port via which a probe portion (e.g., SPME fiber) of a SPME assembly is received into a sealed volume of the pressure vessel. The probe portion of the SPME assembly is coated with an extracting phase material, the analytes being absorbed into and/or adsorbed onto the extracting phase material. The pressure vessel is configured for providing an environment in which desorption of the analytes from the extracting phase material occurs at a gaseous pressure which is substantially less than atmospheric pressure (e.g., less than 100 mTorr). The desorbed analytes are then directed to the vacuum chamber of the analytical instrument system via an outlet port of the pressure vessel. 1. A sample introduction system , comprising:a pressure vessel having an enclosure forming a sealed volume;an inlet port connected to the enclosure, the inlet port configured to receive a probe portion of a solid phase micro extraction assembly into the sealed volume, the probe portion being coated with an extracting phase material, the analyte being at least one of adsorbed onto or absorbed into the extracting phase material;an outlet port connected to the enclosure; anda desorption apparatus located within the sealed volume, the desorption apparatus configured to heat the analyte for causing desorption of the analyte from the extracting phase material.2. The sample introduction system as recited in claim 1 , wherein the pressure vessel comprises a load lock.3. The sample introduction system as recited in claim 1 , wherein the pressure vessel is configured to be connected to a vacuum for establishing a gaseous pressure within the sealed volume claim 1 , the gaseous pressure being substantially less than atmospheric pressure.4. ...

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06-02-2014 дата публикации

KNIFE HOLDER HAVING A BLADE CHANGING APPARATUS

Номер: US20140033888A1
Автор: WALTER Roland
Принадлежит: LEICA BIOSYSTEMS NUSSLOCH GMBH

The invention relates to a knife holder () having a blade changing apparatus (). The knife holder has a first blade receptacle () defining a cutting position, a securing means () for securing a blade () received in the first blade receptacle (), a second blade receptacle () defining an output position, and an ejection means () for ejecting a blade () received in the first blade receptacle () out of the first blade receptacle (). The first and the second blade receptacles are arranged in the knife holder in such a way that a blade ejected from the first blade receptacle () can travel by gravity into the second blade receptacle (). 1100101. A knife holder () having a blade changing apparatus () , the knife holder comprising:{'b': '111', 'a first blade receptacle () defining a cutting position;'}{'b': 130', '141', '142', '201', '111, 'a securing means (, , ) for securing a blade () received in the first blade receptacle (),'}{'b': '112', 'a second blade receptacle () defining an output position; and'}{'b': 141', '143', '144', '201', '111', '111, 'i': 'a', 'an ejection means (, , ) for ejecting a blade () received in the first blade receptacle () out of the first blade receptacle ();'}{'b': 111', '112, 'the first blade receptacle and the second blade receptacle being arranged in the knife holder in such a way that a blade ejected from the first blade receptacle () travels by gravity into the second blade receptacle ().'}2100111112100. The knife holder () according to claim 1 , the first blade receptacle () and the second blade receptacle () being arranged vertically spaced apart in the knife holder ().3100301201410111. The knife holder () according to claim 1 , further comprising a first external mounting location for a blade supply container and a first driver () for conveying a first blade () out of a blade supply container () externally mounted at the first external mounting location into the first blade receptacle ().4100111. The knife holder () according to claim 3 ...

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06-02-2014 дата публикации

Blade dispenser

Номер: US20140034665A1
Автор: Roland Walter
Принадлежит: LEICA BIOSYSTEMS NUSSLOCH GMBH

A blade dispenser ( 100 ) has a blade supply container ( 110 ), a blade disposal container ( 120 ), and a detachable and reconnectable connecting means ( 130, 131, 132 ) that is embodied to connect the blade supply container ( 110 ) and blade disposal container ( 120 ) detachably to one another. The blade supply container ( 110 ) has a blade supply container upper side and a blade supply container underside, and is embodied to receive a blade stack ( 111 ) made up of multiple mutually abutting blades ( 112, 115 ). The blade supply container ( 110 ) also has a removal opening ( 116 ) through which at least one blade ( 112, 115 ) of the blade stack ( 111 ) is removable from the blade supply container ( 110 ). The blade disposal container ( 120 ) has a blade disposal container upper side and a blade disposal container underside, and is embodied to receive blades ( 120 ) to be disposed of.

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13-02-2014 дата публикации

Sliced specimen preparing apparatus

Номер: US20140041500A1
Принадлежит: Kurashiki Spinning Co Ltd

To improve the freedom in material selection of cutter while suppressing increase in loads on the operator, a sliced specimen preparing apparatus of the present invention includes a cutter storage section storing a plurality of cutters, a specimen block cutting unit holding a cutter and slicing a surface layer of a specimen block, and a cutter transfer unit transferring a cutter stored in the cutter storage section to the specimen block cutting unit and replacing the cutter held by the specimen block cutting unit, the specimen block cutting unit is movable between a sliceable position where a blade edge of the cutter is oriented obliquely downward and a replacement position where the blade edge of the cutter is horizontally or oriented obliquely upward, and the cutter transfer unit replaces the cutter held by the specimen block cutting unit when the specimen block cutting unit is located at the replacement position.

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20-02-2014 дата публикации

METHOD, SYSTEM AND APPARATUS FOR USE IN LOCATING SUBSURFACE ORE BODIES

Номер: US20140047932A1
Принадлежит: GLOBAL SCIENTIFIC SERVICES PTY LTD

A method and system for locating subsurface ore bodies. Samples of near surface soil are collected over a predetermined geographical area. The samples are analysed to discover any chemical anomalies in the dust particles as a way of identifying possible subcropping mineralization. A tine () and collection tube () engage into subsurface soil and samples are drawn up the tube into a dust collection module (). Sub 5 micron particles are captured on an electrostatically charged tape (). Consecutive samples are indexed on the tape e.g. with a barcode. Collected dust samples are ablated by a laser ablation cell () and the ablated sample analysed by a mass spectrometer for presence of ions indicating presence of a resource body, such as a body of ore, minerals or hydrocarbons. 1A method for locating subsurface ore bodies , the method comprising: taking samples of sub-surface soil over a predetermined geographical area , and analyzing particles of dust from the samples to discover any chemical anomalies in the dust particles as a way of identifying possible subcropping mineralization.2. A method according to claim 1 , further comprising:establishing waypoints for taking the samples in a preselected geographical area; andtaking a sample at each waypoint and simultaneously recording the GPS coordinates of each waypoint.3. A method as claimed in claim 1 , further comprising storing the samples in a contamination-free environment for conducting the analysis for hydromorphic anomalies in the samples.4. A method as claimed in claim 1 , further comprising: transporting a dust collection apparatus over the terrain in the geographical area according to predetermined waypoints;inserting a sampling probe into the surface soil at selected ones of said waypoints;drawing a sample of dust up into the dust collection apparatus;storing the dust sample from each waypoint in the dust collection apparatus in a contamination-free environment; and,recording the GPS coordinates of each selected ...

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20-02-2014 дата публикации

Sliced specimen preparing apparatus

Номер: US20140051158A1
Принадлежит: Kurashiki Spinning Co Ltd

A sliced specimen preparing apparatus prepares a sliced specimen by slicing a surface of a specimen block in which a specimen is embedded in an embedding-substance. The apparatus includes: a cutter configured to slice the surface of the specimen block; a surface exposure determination unit configured to determine whether or not the area of a specimen portion on the surface of the specimen block is sufficient for the preparation of the sliced specimen; a specimen block transporting unit configured to transport the specimen block between the surface exposure determination unit and the cutter. The surface exposure determination unit includes a humidifying unit configured to humidify the surface of the specimen block; an irradiating unit configured to irradiate the surface of the specimen block with light; an imaging unit configured to receive reflected light from the humidified surface of the specimen block which is irradiated from the irradiating unit to acquire image data; an image data processing unit configured to discriminate the specimen portion on the surface of the specimen block from the embedding-substance portion based on the image data acquired by the imaging unit; and a controller configured to control the imaging unit, the irradiating unit, and the image data processing unit, and to determine whether or not the area of the specimen portion on the surface of the specimen block, the specimen portion being acquired by the image data processing unit, is sufficient for the preparation of the sliced specimen.

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27-02-2014 дата публикации

APPARATUS AND METHODS FOR ALIQUOTTING FROZEN SAMPLES

Номер: US20140053664A1
Автор: Basque Todd, Chin Larry
Принадлежит: CRYOXTRACT INSTRUMENTS, LLC

A single-use coring probe for collecting a frozen aliquot from a frozen biological sample includes a hollow coring bit and an ejector adapted. The ejector is operable to eject a frozen sample core from the bit as it moves from a retracted position to an extended position. Use of the ejector converts the probe to a disabled configuration to discourage reuse of the coring probe to obtain another sample. The probe may include a locking mechanism adapted to prevent re-use of the single-use coring probe by locking the ejector in the extended position. A hand-held coring device can be used to take frozen sample cores from frozen samples. A tissue container is suitable for holding a frozen tissue sample in frozen storage and also for holding the sample while the sample is sectioned and/or a full-depth frozen sample core is extracted from the frozen tissue. 1. A single-use coring probe for collecting a frozen aliquot from a frozen biological sample , the single-use coring probe comprising:a hollow coring bit for taking a frozen sample core from the frozen biological sample;an ejector adapted to eject the frozen sample core taken by the hollow coring bit from the hollow coring bit, the ejector being moveable from a retracted position to an extended position and operable to push a frozen sample core out of the coring bit as it moves from the retracted position to the extended position; anda locking mechanism adapted to prevent re-use of the single-use coring probe.2. A single-use coring probe as set forth in wherein the locking mechanism is automatically activated upon movement of the ejector to the extended position.3. A single-use coring probe as set forth in claim 1 , wherein the locking mechanism is adapted to prevent movement of the ejector from the extended position toward the retracted position.4. A single-use coring probe as set forth in claim 1 , wherein the ejector does not extend beyond a distal end of the hollow coring bit in the retracted position and the ejector ...

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13-03-2014 дата публикации

Method and Apparatus for Creating Nondestructive Inspection Porosity Standards

Номер: US20140072197A1
Автор: Kathy L. Ferguson
Принадлежит: Boeing Co

A method and apparatus for establishing nondestructive inspection porosity standards. In one illustrative embodiment, a plurality of samples is formed using a different technique for each sample in the plurality of samples such that each sample in the plurality of samples has a different porosity from other samples in the plurality of samples. Each sample in the plurality of samples has a same set of selected properties as a selected part type. A porosity level is identified for each sample using volumetric data extracted from a three-dimensional image for each sample generated using a computed tomography system. A group of standards is established for a group of selected porosity levels from the plurality of samples based on the porosity level identified for each sample in the plurality of samples. The group of standards is configured for use in performing nondestructive inspection of a part of the selected part type.

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27-03-2014 дата публикации

Device and a Method for Collecting and Transferring Samples of Biological Material

Номер: US20140083213A1
Автор: Triva Daniele
Принадлежит: Copan Italia S.p.A.

A device () for collecting and transferring samples of biological material, where the device comprises at least: a support body () having at least a first end portion () and at least a gripping portion (), and a plurality of fibres () attached to and arranged on the first portion () of the support body () by flocking, such as to define a flocked collecting portion () suitable for collecting, on the collecting portion (), a quantity of a sample of biological material, where the support body () is made of polyamide (PA or nylon), in particular polyamide 66 (PA66 or nylon 66). The support body can be provided with at least a weakened portion () suitable for enabling a selective breaking of the support body and a separation of the collecting portion () at least from a part of the gripping portion (). 11. A device () for collecting and transferring samples of biological material , wherein the device comprises at least:{'b': 2', '2', '2, 'i': a', 'b, 'a support body () having at least a first end portion () and at least a gripping portion (), and'}{'b': 6', '2', '2', '3', '3', '2, 'i': 'a', 'a plurality of fibres () attached to and arranged on said first portion () of said support body () by flocking, for defining a flocked collecting portion () apt to collect, on said collecting portion (), a quantity of a sample of biological material, wherein said support body () is made of polyamide (PA or nylon), in particular polyamide 66 (PA66 or nylon 66).'}21. The device () of claim 1 , wherein said support body is bendable without breaking at least up to reaching a radius of curvature of 5 mm claim 1 , or of 4 mm or of 3 mm or of 2 mm or of 1 mm and/or wherein said support body is bendable without breaking in correspondence of at least 10 cycles claim 1 , or 20 cycles claim 1 , or 50 cycles claim 1 , or 100 cycles or 200 cycles of bending by 90° in opposite directions at ambient temperature of about 25 C°.31432b. The device () of claim 1 , wherein said support body is provided ...

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03-04-2014 дата публикации

MICROTOME FOR PRODUCING SECTIONS OF SPECIMENS

Номер: US20140090531A1
Автор: Schmitt Christoph
Принадлежит: LEICA BIOSYSTEMS NUSSLOCH GMBH

A microtome for producing sections of a specimen having a knife for sectioning the specimen and a cooling apparatus for cooling a gaseous coolant cooling the specimen. A database stores data of various tissue types and target temperatures that are allocated to these various tissue types. A reading unit is adapted to read a code from a specimen or from a specimen carrier unit allocated to the specimen and a control unit is adapted to determine the tissue type of the tissue of the specimen by the code that has been read. The control unit is adapted to read the target temperature of the specimen to be sectioned for controlling the cooling apparatus and setting this target temperature and is adapted to control the cooling apparatus such that the cooling power is controlled to preset target temperature. 1. A microtome for producing sections of a specimen , comprising:a knife for sectioning the specimen;a cooling apparatus for cooling a gaseous coolant, wherein the cooling apparatus generates a coolant flow of the gaseous coolant and the specimen is positionable in that coolant flow;a database storing data representing various tissue types and target temperatures that are allocated to these various tissue types;a reading unit adapted to read a code from a specimen or from a specimen carrier unit allocated to the specimen; anda control unit adapted to determine the tissue type of the tissue of the specimen by the code that has been read; whereinthe control unit is adapted to read the target temperature of the specimen to be sectioned for controlling the cooling apparatus and setting this target temperature; andthe control unit is adapted to control the cooling apparatus such that the cooling power is controlled to preset target temperature.2. The microtome according to claim 1 , wherein the specimen is positionable in the coolant flow during sectioning of the specimen.3. The microtome according to claim 1 , wherein at least a region in which the specimen is positionable is ...

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10-04-2014 дата публикации

Cotton acquisition and tracking system

Номер: US20140096623A1
Принадлежит: Quantitative Engineering Solutions, LLC

Apparatus for a cotton sample acquisition and tracking system. The system includes a loading station in which a pair of primary sample halves are loaded in a carrier. The primary samples are identified and transported to a sub-sample station that extracts a sub-sample from the primary sample. The sub-samples are conditioned and transported to various testing stations. The primary samples are transported via a conveyor system. The sub-samples are transported through a pneumatic system. The sub-sample station advances the primary sample against a pick drum that pulls tufts from the primary sample. The tufts flow through a cotton containment system into an indexer that collects, conditions, and routes the tufts as a sub-sample. The sub-samples are staged in a carousel for continued conditioning and storage until the test equipment is ready to process the sub-sample. 1. An apparatus for acquiring , conditioning , and testing cotton sub-samples , said apparatus comprising:a loading station that receives and identifies a primary sample of fibrous material;a sub-sampler that extracts a sub-sample from said primary sample, said sub-sampler including a sample feed mechanism and a drum, said sample feed mechanism advancing said primary sample against said drum, said drum including a plurality of pucks configured to grab a plurality of fibers from said primary sample that are collected to form a sub-sample, said drum reciprocating with said plurality of pucks moving relative to said primary sample, said sub-sampler further including a shroud around a portion of said drum, said shroud having an outlet at a negative pressure relative to an ambient pressure outside said shroud, said shroud configured to draw air from around said drum through said outlet of said shroud thereby capturing said plurality of fibers extracted from said primary sample;a conditioning system that routes conditioned air through said sub-sample; anda pneumatic routing system configured to transport said sub ...

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10-04-2014 дата публикации

Tissue sampling for pathological study

Номер: US20140098376A1
Автор: Dan Hashimshony, Gil Cohen
Принадлежит: Dune Medical Devices LTD

A probe device for use in a tissue inspection system is presented. The probe device comprises a probe body and a control unit at least partially incorporated in the probe body. The probe body carries at least a tissue characterization unit operable for providing sensing data indicative of at least one tissue property at measurement locations in the tissue portion being held by the probe. The control unit comprises: a processor utility for receiving and processing the sensing data and generating measured data indicative of a spatial profile of said at least one tissue property distribution within the tissue portion, and comprises at least one of the following: an imaging utility for receiving said measured data and generating and displaying an image indicative thereof thereby enabling a user to select a region of said tissue portion for further analysis; and a pattern generator module configured for receiving and analyzing said measured data and determining a pattern indicative of an arrangement of regions in said tissue portion, thereby enabling selection of at least one of the regions for further analysis.

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10-04-2014 дата публикации

Method of Staging a Tissue Sample Cassette

Номер: US20140099661A1
Принадлежит: BIOPATH AUTOMATION, L.L.C.

A method of staging a tissue sample cassette, including a cassette body and a lid, from an upper position in a frame used during a tissue embedding process to a lower position in the frame. The method comprises coupling the cassette with the frame such that the cassette is in the upper position and positively stopped at the upper position by first structure on a wall of the frame. The cassette is moved relative to the frame to the lower position by selectively engaging the cassette with a staging mechanism. An external force is applied to the cassette with the staging mechanism in a direction to move the cassette from the upper position toward the lower position. The cassette is retained in the lower position using second structure on the wall of the frame, such that the cassette is exposed for embedding the cassette in an embedding medium and subsequently slicing the tissue sample embedded in the embedding medium. 1. A method of staging a tissue sample cassette , including a cassette body and a lid , from an upper position in a frame used during a tissue embedding process to a lower position in the frame , the method comprising:coupling the cassette with the frame such that the cassette is in the upper position and positively stopped at the upper position by first structure on a wall of the frame, the cassette including a tissue sample within the cassette body and enclosed by the lid;moving the cassette relative to the frame to the lower position by selectively engaging the cassette with a staging mechanism separate from the cassette, and applying external force to the cassette with the staging mechanism in a direction to move the staging mechanism from the upper position toward the lower position; andretaining the cassette in the lower position using second structure on the wall of the frame, such that the cassette is exposed for embedding the cassette in an embedding medium and subsequently slicing the tissue sample embedded in the embedding medium.2. The method ...

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03-01-2019 дата публикации

Apparatus and method for medical imaging and pathology correlations

Номер: US20190000431A1
Принадлежит: New York University NYU

A primary sample holder for imaging, gross pathology, or histological correlations of a biological sample includes an enclosure having a first side wall, a second side wall, and a bottom wall; a plurality of slots provided at predetermined intervals along the first and second side walls; and a grid recessed within the bottom wall. The grid includes a hole bisected by a central panel and at least one axial panel that intersects the central panel along a length thereof. The biological sample received by the primary sample holder is configured to be aligned with the central panel of the grid to align the biological sample along an accepted internal orientation line (e.g., the anterior-posterior commissure line in the brain). The slots are configured to receive a cutting device to cut the biological sample into slices of uniform thickness containing a region of interest based on histological and imaging findings.

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07-01-2021 дата публикации

SAMPLE EXTRACTING DEVICE AND RESIDUAL SOLVENT MEASURING APPARATUS INCLUDING THE SAME

Номер: US20210001328A1
Принадлежит: SEMES Co. Ltd.

The present invention relates to a sample extracting device and a residual solvent measuring apparatus including the same. The a residual solvent measuring apparatus of the present invention includes a sample extracting device moving on a substrate to extract a solidified sample in a liquid state on the substrate and a component analyzing unit analyzing components of the extracted sample, wherein the sample extracting device includes a coating unit coating a liquid chemical for dissolving the solidified sample on the substrate and a recovering unit recovering the liquid chemical in which the sample is dissolved on the substrate. 1. A sample extracting device for moving on a substrate and extracting a solidified sample , the sample extracting device comprising:a coating unit configured to coat a liquid chemical for dissolving the solidified sample on the substrate; anda recovering unit configured to recover the liquid chemical in which the sample is dissolved on the substrate.2. The sample extracting device of claim 1 , further comprising:a liquid chemical circulation line connecting the coating unit and the recovering unit,wherein the coating unit receives the liquid chemical in which the sample is dissolved from the recovering unit through the liquid chemical circulation line and coats the liquid chemical in which the sample is dissolved on the substrate.3. The sample extracting device of claim 2 , wherein the recovering unit includes a liquid chemical recovery pump for recovering the liquid chemical in which the sample is dissolved claim 2 ,the coating unit includes liquid chemical ejection pump for ejecting the liquid chemical on a substrate, anduntil the sample extraction is completed, the liquid chemical recovery pump supplies the recovered liquid chemical in which the sample is dissolved to the liquid chemical ejection pump of the coating unit.4. The sample extracting device of claim 3 , wherein a first liquid chemical circulation line valve is provided for ...

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06-01-2022 дата публикации

Laser Capture Microdissection Systems and Method for Image Analysis

Номер: US20220004738A1
Автор: Kil David H.
Принадлежит:

A system and method for performing tissue image analysis and region of interest identification for further processing using laser capture microdissection is provided. The invention provides both an interactive mode and a high-throughput batch mode. 1. A computer-implemented method for image analysis , the computer-implemented method comprising:receiving a first image of a first tissue sample using laser capture microdissection;selecting a database containing parameters;classifying the first image into at least one region of interest employing the parameters from the database;updating the parameters of the database with data from the first image to produce updated parameters;capturing a second image of a tissue sample using laser capture microdissection, classifying the second image into regions of interest employing the updated parameters from the database based; andupdating the parameters of the database a second time with data from the second image.2. The computer-implemented method for image analysis of claim 1 , further comprising claim 1 , classifying at least one of the first image or the second image into at least one non-region of interest employing the parameters from the database.3. The computer-implemented method for image analysis of claim 1 , wherein the first image and the second image are captured from the same tissue sample.4. The computer-implemented method for image analysis of claim 1 , wherein the first image and the second image are captured from the different tissue samples. This application claims priority to U.S. Provisional Application Ser. No. 60/410,433, entitled “INTERACTIVE AND AUTOMATED TISSUE IMAGE ANALYSIS WITH GLOBAL TRAINING DATABASE AND VARIABLE-ABSTRACTION PROCESSING IN CYTOLOGICAL SPECIMEN CLASSIFICATION AND LASER CAPTURE MICRODISSECTION APPLICATIONS”, filed on Sep. 13, 2002 which is incorporated herein by reference in its entirety.The invention relates generally to automated tissue image analysis, and in particular, to image ...

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05-01-2017 дата публикации

Method, system, and device for automating transfer of tape to microtome sections

Номер: US20170003309A1
Принадлежит: Clarapath Inc

A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.

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03-01-2019 дата публикации

IMPROVEMENTS IN AND RELATING TO CELL HARVESTING APPARATUS

Номер: US20190002817A1
Автор: Dowling Jim, Harris Dan
Принадлежит: GE HEALTHCARE BIO-SCIENCES CORP.

Disclosed herein is a cell harvesting instrument suitable for concentrating cells from a source suspension of cells and/or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump, at least one valve; and a processing kit removably insertable into the housing, said kit including a generally flat frame having or supporting plural sealed fluid paths arranged in a generally flat plane and such that fluids in the paths do not contact said mechanical elements, wherein at least portions of the fluid paths comprise flexible tubes, the outer surfaces of which are manipulateable by the or each fluid pump, to provide fluid flow in one or more of the paths and/or by the or each valve to restrict fluid flow in one or more of the paths. In an embodiment, the kit comprises also a fluid processing reservoir and a filter suitable for separating cells from fluid in said paths. A transfer mechanism for moving and weighing the fluid processing reservoir is disclosed also. 1. A pinch valve mechanism operable to pinch a flexible tube against a reaction surface , the mechanism comprisingat least one pivotable arm including on one side a finger to perform said pinching and on an opposing side a cam profile, anda linearly moveable actuator in use acting on the or each cam profile to move an associated finger.2. The mechanism of claim 1 , wherein the at least one pivotable arm comprises a first arm and a second arm each operable to pinch a different tube claim 1 , and wherein the first and second arms share the same actuator.3. The mechanism of claim 2 , wherein the cam profiles of the first and second arms are the same or similar in profile but opposed in orientation such that when the finger of the first arm provides a pinching action the finger of the second arm provides no pinching action claim 2 , and vice versa.4. The mechanism of claim 3 , wherein the opposed cam profiles of the first and second arms have a ...

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02-01-2020 дата публикации

MAGNETIC NEEDLE SEPARATION AND OPTICAL MONITORING

Номер: US20200003660A1
Принадлежит:

Apparatuses and methods for removing magnetic particles from suspensions are described. One embodiment of the apparatus is called a magnetic needle. 1. A method for the separation of magnetic particles from a suspension , comprising:(a) placing a magnetic separation device in magnetic communication with the suspension;(b) subjecting the suspension to incident light at a first wavelength;(c) determining a measure of light at the first wavelength after interaction with the suspension;(d) removing the magnetic separation device from magnetic communication with the suspension responsive to the measure of light.2. The method of claim 1 , wherein determining a measure of light comprises determining a measure of light intensity after light has traveled through the suspension.3. The method of claim 2 , wherein the measure of light intensity is a measure of the rate of change of light intensity.4. The method of claim 2 , wherein the measure of light intensity is a measure of the intensity of light collected compared to the intensity of incident light.5. The method of claim 3 , wherein step (d) comprises removing the magnetic separation device when the rate of change is below a predetermined threshold.6. The method of claim 5 , wherein the predetermined threshold is zero.7. The method of claim 4 , wherein step (d) comprises removing the magnetic separation device when the ratio of the intensity of light collected to the intensity of incident light is below a predetermined threshold.8. The method of claim 2 , wherein step (d) comprises removing the magnetic separation device when the intensity of light collected is below a predetermined threshold.9. The method of claim 1 , wherein step (a) comprises placing a magnetic needle into the suspension claim 1 , and wherein step (d) comprises removing the magnetic needle from the suspension.10. The method of claim 10 , wherein step (a) comprises placing a removable sheath over the magnetic needle prior to placing the magnetic needle ...

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03-01-2019 дата публикации

Cartridges for sample partitioning

Номер: US20190003930A1
Принадлежит: 3M Innovative Properties Co

Cartridges for sample partitioning and methods of making and using the cartridges are provided. The cartridges include a pouch to receive a mated stem-well film and a sealing film covered by a release liner. The stem film and the sealing film can be respectively separated from the well film and sealing film simultaneously by pulling a pull tab.

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03-01-2019 дата публикации

PHOTODEGRADABLE SAMPLE COLLECTION SYSTEM AND METHOD

Номер: US20190003940A1
Принадлежит:

A method includes providing a biological sample, providing a sample collection device, wherein the sample collection device includes a sample binding surface including a photodegradable polymer configured to bind the biological sample, contacting the biological sample with the sample binding surface of the sample collection device, and irradiating the sample binding surface and the bound biological sample using light emitted from a light source to initiate degradation of the photodegradable polymer of the sample binding surface to cause release of the biological sample. 1. A method , comprising:providing a biological sample;providing a sample collection device, wherein the sample collection device comprises a sample binding surface comprising a photodegradable polymer configured to bind the biological sample;contacting the biological sample with the sample binding surface of the sample collection device;irradiating the sample binding surface and the bound biological sample using light emitted from a light source to initiate degradation of the photodegradable polymer of the sample binding surface to cause release of the biological sample.2. The method of claim 1 , wherein the photodegradable polymer comprises one or more hydrophobic polymers.3. The method of claim 1 , wherein the photodegradable polymer is water insoluble in polymer form.4. The method of claim 1 , wherein irradiating the sample binding surface and the bound biological sample comprises irradiation claim 1 , and wherein the light comprises light of a wavelength greater than 300 nm.5. The method of claim 1 , wherein the degradation of the photodegradable polymer comprises cleaving one or more photocleavable moieties of the photodegradable polymer to break the photodegradable polymer into a plurality of polymers claim 1 , monomers claim 1 , oligomers claim 1 , or a combination thereof claim 1 , wherein the plurality of polymers claim 1 , monomers claim 1 , oligomers claim 1 , or a combination thereof is ...

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03-01-2019 дата публикации

Automatic Titration Device

Номер: US20190003961A1
Автор: Kenowski Andy
Принадлежит:

A titration system is disclosed for determining content of an analyte in a sample. The titration system comprises: a controller; a reaction vessel; a titration vessel and an indicator vessel in fluid communication with the reaction vessel; a spectroscopy unit; a sensor for outputting a signal to the controller based on a force exerted by the reaction vessel on the sensor. The controller executes a stored program to: (i) perform titration by delivering to the reaction vessel a first mass of a first fluid comprising the sample, a second mass of a second fluid comprising indicator, and a third mass of a third fluid comprising titrant; (ii) detect color change in the mixture in the reaction vessel based on a signal from the spectroscopy unit and stop titration; and (iii) calculate content of the analyte in the sample based on the first mass, the second mass, and the third mass. 1. A titration system for determining content of an analyte in a sample , the titration system comprising:a controller;a reaction vessel for containing the sample comprising the analyte;a titration vessel in fluid communication with the reaction vessel;an indicator vessel in fluid communication with the reaction vessel;a spectroscopy unit in electrical communication with the controller, the spectroscopy unit including a radiation source and a receiver positioned adjacent to the reaction vessel to detect a color change in a mixture in the reaction vessel;a sensor in electrical communication with the controller, the sensor being positioned adjacent to the reaction vessel, the sensor outputting a signal to the controller based on a force exerted by the reaction vessel in a direction toward the sensor; (i) perform titration by delivering a first mass of a first fluid comprising the sample to the reaction vessel, delivering a second mass of a second fluid comprising an indicator to the reaction vessel, delivering a third mass of a third fluid comprising a titrant to the reaction vessel to create the ...

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08-01-2015 дата публикации

FORENSIC COLLECTION DEVICE

Номер: US20150007671A1
Автор: Dobrowolski Peter
Принадлежит:

The present invention discloses a device as well as a collection element (1) for collecting a chemical and/or biological sample directly from a surface exposing said sample material. Furthermore, a method for collecting a chemical and/or biological sample directly from a surface exposing said sample material and a kit thereof is subject-matter of the present invention. 1. A device for collecting a forensic biological and/or chemical sample directly from a surface exposing said sample material comprising{'b': 5', '4, '(i) a holding element () comprising a plug () at a first end,'}{'b': 6', '5, '(ii) a releasing element () connected to the holding element () and'}{'b': 1', '1, '(iii) a collection element () comprising, on the lateral area of the collection element (), a collection surface on which said sample is deposited and at least one side surface,'}{'b': 1', '1, 'wherein the plug extends into the collection element () along or parallel to the longitudinal axis of the collection element (),'}{'b': 1', '5, 'wherein the collection element () is attached in a mechanically detachable fashion to the holding element (), and'}{'b': 6', '1', '1', '5, 'wherein the releasing element () is capable of exerting a mechanical force to the side surface of the collection element () such that the collection element () is detached from the holding element ().'}2563. The device according to claim 1 , wherein the second end of the holding element () and the releasing element () are connected directly to each other or are connected via a handhold ().3563. The device according to claim 2 , wherein the holding element () claim 2 , the releasing element () and the handhold () are integral.45. The device according to any one of the to claim 2 , wherein the holding element () is L- claim 2 , Z- or U-shaped.53. The device according to any one of the to claim 2 , wherein the collection surface is perpendicular to the handhold ().615154. The device according to any one of the preceding claims ...

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20-01-2022 дата публикации

ANALYZER AND ANALYSIS METHOD

Номер: US20220018743A1
Автор: TAKIMOTO Miki
Принадлежит: Kioxia Corporation

An analysis system includes a stage that supports a sample. The analysis system includes a first supplier configured to provide a hydrophobic material on the sample, and surround an inspection region on the sample with the hydrophobic material. The analysis system includes a second supplier configured to provide an inspection liquid over the inspection region. The analysis system includes a collector configured to collect the inspection liquid. The analysis system includes an analyzer configured to analyze a component contained in the collected inspection liquid. 1. An analysis system , comprising:a stage that supports a sample;a first supplier configured to provide a hydrophobic material on the sample, and surround an inspection region on the sample with the hydrophobic material;a second supplier configured to provide an inspection liquid over the inspection region;a collector configured to collect the inspection liquid; andan analyzer configured to analyze a component contained in the collected inspection liquid.2. The analysis system according to claim 1 , further comprising:a memory that stores coordinate information of the inspection region on the sample; anda first drive mechanism that moves the first supplier to surround the inspection region with the hydrophobic material, based upon the coordinate information.3. The analysis system according to claim 2 , further comprising:a second drive mechanism that moves at least one of the second supplier or the collector above the inspection region, based upon the coordinate information.4. The analysis system according to claim 1 , whereinthe second supplier and the collector share the same nozzle.5. The analysis system according to claim 1 , whereinthe analyzer is configured to detect a metal component contained in the inspection liquid.6. The analysis system according to claim 1 , whereinthe hydrophobic material has hydrophobicity.7. The analysis system according to claim 1 , wherein{'sub': 2', '2', '2', '2', '2', '3 ...

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10-01-2019 дата публикации

Process for Realising a Device for Collecting and Transferring Samples for Molecular Biology

Номер: US20190008489A1
Автор: Triva Daniele
Принадлежит: Copan Italia S.p.A.

A process for realising a device () for collecting and transferring samples for molecular biology, the device including at least: a support body () having at least a first portion (), and a plurality of fibres () attached and arranged on the first portion () of the support body () by flocking, such as to define a flocked collecting portion () destined to collect, on the said collecting portion, () a quantity of the sample for molecular biology, the process including at least a step of pre-treating the plurality of fibres () with a surfactant, the step of pre-treating the plurality of fibres () with a surfactant being performed after application of the fibres on the support body () by flocking and/or before application of the fibres () on the body () by flocking and/or wherein the surfactant is added to the fibre () during production of the fibre (). 120-. (canceled)21122622336aa. A device () for collecting and transferring samples for molecular biology comprising a support body () , having at least a first portion () , and a plurality of fibres () attached and arranged on the first portion () of the support body () by flocking , such as to define a flocked collecting portion () destined to collect , on the collecting portion () , a quantity of sample for molecular biology , the plurality of fibres () being pre-treated with a surfactant , such as to increase a quantity of DNA or RNA releasable by the collecting device and usable for molecular biology operations.221. The device () of claim 21 , wherein the surfactant is at least one of cationic or benzalkonium chloride (BAC).231. The device () of claim 21 , wherein the surfactant is cationic and is a salt having a positive part claim 21 , constituted by at least a chain of carbon atoms terminating with a quaternary ammonium group; and wherein the surfactant is a quaternary ammonium salt or wherein it comprises a mixture of quaternary ammonium salts.241. The device () of claim 21 , wherein the surfactant is a mixture ...

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11-01-2018 дата публикации

Method and Apparatus For a Cone Penetration Test With Whipstock-Enabled Soil Sampling

Номер: US20180010987A1
Автор: Lynk John M.
Принадлежит:

A method and apparatus for geotechnical soil sampling in conjunction with the Cone Penetration Test (CPT) is provided. The apparatus involves a tubular whipstock cell affixed between push rods and the lower elements of a cone penetrometer. The whipstock cell includes a whipstock having a beveled face. The whipstock face is oriented towards a sampling window pre-formed in the whipstock cell. The apparatus also includes at least one push rod connected to the proximal end of the whipstock cell, and an elongated sampling rod dimensioned to be slidably moved through the at least one push rod en route to the whipstock cell. The apparatus additionally comprises a soil sampler residing at a distal end of the push rod. A method of taking soil samples is also provided herein. 1. An apparatus for taking soil samples from subsurface soil strata , comprising:an elongated tubular whipstock cell having a proximal end and a distal end;a through-opening along a portion of the whipstock cell comprising a pre-formed window;a whipstock residing within the whipstock cell, the whipstock having a face angled towards the pre-formed window;at least one push rod connected to the proximal end of the whipstock cell, the push rod representing a tubular body;an elongated sampling rod dimensioned to be slidably moved through an inner diameter of the at least one push rod en route to the whipstock cell;a mechanical soil sampler configured to extend through the pre-formed window; anda bent sub having a proximal end and a distal end, wherein the proximal end is connected to a distal end of the sampling rod, and the distal end is connected to the soil sampler, and wherein the bent sub is configured to deflect off of the whipstock face when urged through the pre-formed window.2. The soil sampling apparatus of claim 1 , further comprising:a cone penetrometer residing at or below a distal end of the whipstock cell, the cone penetrometer comprising a conical tip and a friction sleeve.3. The soil sampling ...

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10-01-2019 дата публикации

POLARIZATION DIELECTRIC DISCHARGE SOURCE FOR IMS INSTRUMENT

Номер: US20190011400A1
Автор: Nacson Sabatino
Принадлежит:

An IMS ionizer comprising a wire, a second conductor, and a dielectric, when the first conductor and second conductor are energized to an ionization voltage, discharge ionization occurs. The dielectric is a glass element formed in a tubular shape defining an inner wall. The wire is formed in coils in contact with said inner wall. The second conductor is positioned to define an outer wall of the tube. The tube has an inlet end for receiving the sample, and an outlet end through which the sample exits after ionization. 1. An ionizing apparatus for use in ionizing molecules in a test sample to be analyzed using an ion-mobility spectrometer , the apparatus comprising:a first conductor, a second conductor, and a dielectric, the first conductor, second conductor, and dielectric being sized, shaped and mutually positioned such that when the first conductor and second conductor are energized to an ionization voltage, discharge ionization occurs at an interface between the first conductor and the dielectric;the dielectric comprising a glass element formed in a tubular shape so as to define an inner wall of a tube, the dielectric being positioned between the first conductor and the second conductor to insulate the first conductor from the second conductor;the first conductor comprising a wire formed in coils that are in contact with said inner wall, and being electrically connectable to an AC voltage pulse generator;the second conductor comprising a conducting layer positioned so as to define an outer wall of the tube, and being electrically connectable to the AC voltage pulse generator;the tube comprising an inlet end for receiving the sample, and an outlet end through which the sample exits after ionization.2. An apparatus as claimed in claim 1 , wherein the wire comprises a generally helically shaped wire defining a longitudinal axis claim 1 , and wherein said longitudinal axis is itself shaped generally helically so as to form said coils with said wire.3. An ionizing ...

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10-01-2019 дата публикации

Methods to determine cancer treatment using robotic high-throughput drug sensitivity testing

Номер: US20190011434A1
Автор: Robert M. Hoffman
Принадлежит: Anticancer Inc

The present invention describes an in vitro test for drug sensitivity for each cancer patient that is performed with a patient's tumor tissue obtained by surgery or biopsy on an automated tissue processor using multi-well tissue-culture plates containing approximately 1 mm3 tumor tissue culture medium and cancer drug. The present invention will accurately identify both effective and in effective drugs for each patient.

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10-01-2019 дата публикации

FECES SAMPLING CONTAINER, METHOD FOR MEASURING COMPONENTS IN FECES SAMPLE, METHOD FOR STABILIZING COMPONENTS IN FECES SAMPLE, AND METHOD FOR STORING FECES SAMPLE

Номер: US20190011462A1
Принадлежит: KYOWA MEDEX CO., LTD.

A feces sampling container having an increased storage stability of a component in a feces sample such as hemoglobin to enable the measurement of a component in a feces sample with a small amount of feces collected. The container includes a container body, and a feces sampling stick having a gripping part on one side and a stick part on the other side, the stick part having a feces sampling part in the vicinity of the tip, wherein the container body comprises an opening part through which the feces sampling part of the feces sampling stick is inserted, and a feces container chamber in which a desiccant is enclosed, wherein the feces sample held by the feces sampling part is dried by a contact of the feces sampling part, which is inserted through the opening part and holding the feces sample, with the desiccant. 1. A feces sampling container comprising:a container body, anda feces sampling stick having a gripping part on one side and a stick part on the other side, the stick part having a feces sampling part in the vicinity of the tip thereof,wherein the container body comprises:an opening, part through which the feces sampling part of the feces sampling stick is inserted, anda feces container chamber in which a desiccant is enclosed therein,wherein the feces sample held by the feces sampling part is dried by a contact of the feces sampling part, which is inserted through the opening part and holding the feces sample, with the desiccant, and the feces sample in a dried state is stored in the desiccant.2. The feces sampling container according to claim 1 , wherein the opening part comprises a leveling hole for removing excess feces.3. The feces sampling container according to claim 1 , wherein the feces container chamber is formed with a fitting body fitted in the container body.4. The feces sampling container according to claim 3 , wherein the fitting body is comprised of an upper fitting block and a lower fitting block.5. The feces sampling container according to ...

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10-01-2019 дата публикации

Sampling device

Номер: US20190011472A1
Автор: Erwin Trummer
Принадлежит: Zeta Biopharma GmbH

A sampling device (1) for filling a sample vessel (4) with sample material from a material container, wherein the sampling device (1) comprises a first locking unit (2), a sterilization unit and a sampling chamber (3), wherein the sampling chamber (3) has an internal chamber space (5), a manipulation unit (6), an opening unit (7) arranged within the internal chamber space (5) as well as a coupling unit (8) arranged within the internal chamber space (5), the first locking unit (2) is arranged between the material container and the coupling unit (8), and the sterilization unit is connected to the internal chamber space (5) and configured to sterilize the internal chamber space (5), wherein the manipulation unit (6) is configured to accommodate the sample vessel (4) at least in part within the internal chamber space (5), movable between the opening unit (7) and the coupling unit (8), the opening unit (7) is configured to open and close the sample vessel (4), and the coupling unit (8) is configured to be coupleable to the sample vessel (4).

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15-01-2015 дата публикации

MICROTOME WITH SURFACE ORIENTATION SENSOR TO SENSE ORIENTATION OF SURFACE OF SAMPLE

Номер: US20150013512A1
Принадлежит:

A sample sectioning device includes a cutting mechanism, a sample holder, a drive system, and a surface orientation sensor. The sample holder is operable to hold a sample. The cutting mechanism is operable to cut sections from the sample. The drive system is coupled with the sample holder. The drive system is operable to drive movement between the sample held by the sample holder and the cutting mechanism. The surface orientation sensor is operable to sense an orientation of a surface of the sample held by the sample holder. 1. A method comprising:positioning a sample that is held by a sample sectioning device relative to a surface orientation sensor;sensing an orientation of a surface of the sample held by the sample sectioning device with the surface orientation sensor;adjusting the orientation of the surface of the sample held by the sample sectioning device so that the surface of the sample is more parallel with a cutting plane associated with a cutting mechanism of the sample sectioning device; andproducing a section of the sample with the sample sectioning device after adjusting the orientation of the surface of the sample.2. The method of claim 1 , wherein sensing the orientation of the surface of the sample with the surface orientation sensor comprises rotating the surface orientation sensor in two dimensions.3. The method of claim 2 , wherein rotating the surface orientation sensor in the two dimensions comprises rotating a first member about a first axis and rotating a second member about a second axis claim 2 , the first axis substantially perpendicular to the second axis.4. The method of claim 2 , further comprising:moving a portion of the surface orientation sensor away from the sample as the sample exerts force on the portion of the surface orientation sensor; andsensing an amount by which the portion of the surface orientation sensor moves away from the sample.5. The method of claim 1 , wherein adjusting comprises the sample sectioning device ...

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09-01-2020 дата публикации

Reciprocating Microtome

Номер: US20200011767A1
Принадлежит:

A microtome for cutting fresh tissue slices from a specimen directs a reciprocating blade along a slicing path such that a cutting edge of the blade traverses a slicing window at an angle that is preferably perpendicular, or near perpendicular, to the slicing path. A blade drive motor drives the cutting edge of the blade in a reciprocating motion, in a longitudinal direction, via an eccentric coupled to a blade holder by a rigid link. Preferred embodiments include a specimen actuator disposed to urge the specimen into the slicing window, and a slidably-removable buffer tray disposed to receive a tissue slice cut from the specimen. 1. An apparatus for cutting a slice from a specimen with a blade having a longitudinal blade edge , the apparatus comprising:a base defining a plane;a blade holder movably mounted to the base so as to move the blade along a slicing path, the blade holder disposed such that the longitudinal blade edge forms, relative to the plane, a non-zero angle;a drive motor operably coupled to the blade holder to drive the blade holder along the slicing path;a buffer tray assembly removably attached to the base and disposed to receive slices cut from the specimen by the blade; anda micrometer nonmovably mounted to the base.2. The apparatus of claim 1 , wherein the blade holder is disposed such that the longitudinal blade edge forms claim 1 , relative to the plane claim 1 , a fixed angle of at least 14 degrees.3. The apparatus of claim 1 , wherein the blade holder is disposed such that the longitudinal blade edge forms claim 1 , relative to the slicing path claim 1 , a fixed angle between 10 degrees and 20 degrees.4. The apparatus of further comprising:a blade drive system operably coupled to the blade holder, such that the blade drive system is configured to drive the longitudinal edge of the blade in a longitudinal reciprocating motion.5. The apparatus of claim 4 , wherein the blade drive system is configured to drive the longitudinal edge of the blade ...

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03-02-2022 дата публикации

PRESERVATION TUBE FOR SAMPLING SWAB

Номер: US20220032287A1
Автор: FANG Pengyu, Jiang Xiwen
Принадлежит: DA AN GENE CO., LTD.

The present invention relates to the technical field of sample preservation, and more specifically, to a preservation tube for a sampling swab which includes a tube body. A first cavity for storing a sample releasing agent and a second cavity for placing the sampling swab are provided in the tube body, the first cavity is in communication with the second cavity, and a central axis of the second cavity deviates from a central axis of the tube body. When the present invention is in use, the sampling swab is placed in the second cavity, moved up and down and rotated to elute in the second cavity, and nucleic acid samples of the sampling swab are evenly distributed in the sample releasing agent, and can be used for detection after sucking the sample releasing agent in the first cavity. 1. A preservation tube for a sampling swab , comprising a tube body , wherein a first cavity for storing a sample releasing agent and a second cavity for placing the sampling swab are provided in the tube body , the first cavity is in communication with the second cavity , and a central axis of the second cavity deviates from a central axis of the tube body.2. The preservation tube for the sampling swab according to claim 1 , wherein the central axis of the first cavity coincides with the central axis of the tube body claim 1 , and a side portion of the second cavity is attached to an inner wall of the tube body.3. The preservation tube for the sampling swab according to claim 1 , wherein a top portion of the tube body is provided with a first connection portion for connecting a tube cap claim 1 , and a bottom portion of the tube body is provided with a fixing portion.4. The preservation tube for the sampling swab according to claim 1 , wherein top portions of the first cavity and the second cavity are connected with a second connection portion claim 1 , the second connection portion surrounds between an outer edge of the top portions of the first cavity and the second cavity and the ...

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19-01-2017 дата публикации

METHODS AND SYSTEMS FOR EXTRACTING DICOT EMBRYOS

Номер: US20170013795A1
Принадлежит: PIONEER HI-BRED INTERNATIONAL, INC.

Methods and systems are provided which permit extraction of a dicot embryo of a dicot seed without damage to the dicot embryo. Methods disclosed herein provide embryos for uses in plant breeding and research procedures. 1. A method of manually or automatically isolating a dicot embryo from an immature dicot seed having a proximal end and an opposed distal end , wherein , prior to removal of the immature dicot seed from its biological carrier , the proximal end of the immature dicot seed is attached to the biological carrier and the distal end of the immature dicot seed is spaced from the biological carrier , the method comprising:a. providing an isolated immature dicot seed having an opening or hole in the proximal end of the dicot seed, wherein the isolated immature dicot seed is provided following removal of the immature dicot seed from the biological carrier; andb. extracting the dicot embryo through the opening or hole in the proximal end of the isolated immature dicot seed, wherein the dicot embryo is undamaged following extraction.2. The method of claim 1 , wherein claim 1 , following extraction of the dicot embryo claim 1 , the dicot embryo retains an ability to grow with full viability and vigor.3. The method of claim 1 , wherein the step of providing the dicot seed comprises removing at least a portion of the proximal end of the dicot seed without damage to the dicot embryo.4. The method of claim 1 , wherein the immature dicot seed is a sunflower seed.5. The method of claim 1 , wherein the immature dicot seed comprises side portions extending between its proximal and distal ends claim 1 , and wherein the step of extracting the dicot embryo through the hole comprises applying pressure to at least one side portion of the dicot seed to force the dicot embryo through the hole in the proximal end of the dicot seed.6. The method of claim 1 , further comprising forming the opening or hole in the proximal end of the dicot seed.7. The method of claim 1 , wherein ...

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09-01-2020 дата публикации

Collection, Release, and Detection of Analytes with Polymer Composite Sampling Materials

Номер: US20200013602A1
Принадлежит: BATTELLE MEMORIAL INSTITUTE

A unique fiber core sampler composition, related systems, and techniques for designing, making, and using the same are described. The sampler is used to interface with existing field instrumentation, such as Ion Mobility Spectrometer (IMS) equipment. Desired sampler characteristics include its: stiffness/flexibility; thermal mass and conductivity; specific heat; trace substance collection/release dependability, sensitivity and repeatability; thickness; reusability; durability; stability for thermal cleaning; and the like. In one form the sampler has a glass fiber core with a thickness less than 0.3 millimeter that is coated with a polymer including one or more of: polymeric organofluorine, polyimide, polyamide, PolyBenzlmidazole (PBI), PolyDiMethylSiloxane (PDMS), sulfonated tetrafluoroethylene (PFSA) and Poly(2,6-diphenyl-p-phenylene Oxide) (PPPO). Multiple polymer coatings with the same or different polymer types may be included, core/substrate surface functionalization utilized, and/or the core/substrate may be at partially filled with thermally conductive particles. 110-. (canceled)11. A method of detecting a substance , comprising:collecting the substance on a sampler, the sampler including a fabric with a polymer applied thereto, at least a portion of the fabric having a thickness of less than or equal to about 0.3 mm and being woven with fibers comprised of one or more of: HSG, carbon, metal, metal oxide, ceramic, and glass-ceramic, the polymer at least partially covering the fabric and being comprised of one or more of: polymeric organofluorine, polyimide, polyimide, PFSA, PBI, PDMS, and PPPO, the sampler having a flexural modulus in a range of about 0.75 GPa through about 10 GPa, the polymer on the fabric being provided in a range of about 20% wt through about 40% wt relative to weight of the sampler with the polymer applied thereto;transferring the substance from the sampler to detection instrumentation; anddetecting the substance with the instrumentation. ...

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03-02-2022 дата публикации

SAMPLING DEVICE FOR SAMPLING FROM A SURFACE OF AN INDUSTRIAL VESSEL WITHOUT REQUIRING A PERSON TO DESCEND INTO AN INDUSTRIAL VESSEL, USING A SWAB

Номер: US20220034758A1
Принадлежит:

Disclosed is a module for sampling from a surface of an industrial vessel without requiring a person to descend into the industrial vessel, using a swab including a stem and a sampling tip, including a swab holder and a conveyor; the swab holder is adapted to receive and secure one end of the swab stem; and the conveyor is configured to set the swab holder in motion on the surface of the vessel. 1. A module for sampling from a surface of an industrial vessel without requiring a person to descend into the industrial vessel using a swab comprising a stem and a sampling tip , comprising a swab holder and a conveyor;the swab holder being adapted to receive and secure one end of the stem of the swab; andthe conveyor being configured to move the swab holder at the surface of the vessel.2. The module according to claim 1 , wherein the conveyor is configured to move the swab holder parallel to the surface.3. The module according to claim 2 , wherein the conveyor is configured to move the swab holder in translational motion along one or two axes parallel to the surface.4. The module according to claim 3 , wherein the conveyor comprises a motor and a transmission assembly for moving the swab holder along a first axis of travel parallel to the surface;the transmission assembly comprising a first annular belt, a second annular belt, a set of four pinions disposed so as to form the corners of a rectangle, and a conveyor bar to which the swab holder is secured and a first end of which is secured to the first annular belt and a second end is secured to the second annular belt so that the conveyor bar is parallel to two opposite sides of the rectangle formed by the set of four pinions;wherein the first belt is disposed so as to surround two pinions on one of the sides of the rectangular perpendicular to the conveyor bar thereby forming two parallel lines, the first end of the conveyor bar being secured to the line the innermost within the rectangle; andwherein the second belt is ...

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03-02-2022 дата публикации

AUTOMATIC SAMPLING SYSTEM AND METHOD

Номер: US20220034759A1
Автор: ABLONET THIERRY
Принадлежит:

An automatic sampling system () and an automated sampling method take samples of a rubber strip after shaping and while scrolling in a predetermined direction. 19.-. (canceled)10. An automatic sampling system for taking samples from a rubber strip after it has been shaped and while it is moving in a predetermined direction , the system comprising:an anvil comprising a cylinder of a predetermined diameter and with a circumferential surface that engages the rubber strip during its movement, the anvil being fixed so that it is rotatable about an axis of rotation; and a die-cutter provided at the sampling end for perforating the rubber strip and for obtaining samples of the rubber strip during its movement, the punch having an annular blade of a predetermined diameter;', 'a fastening and support member provided at the installation end to carry out installation of the punch with respect to a drive shaft to which the punch is rotatably attached, the punch rotating in the same direction as the movement of the rubber strip;', 'an ejector disposed within the housing that moves along a common longitudinal axis among the ejector, the housing and the die-cutter, the ejector comprising a structure with a predetermined length that extends between a release end and an opposite attachment end, the release end comprising a domed surface characterized by a tapered surface area that facilitates release of the sample, and the attachment end comprising a fastener; and', 'a rod cylinder constituting a piston with a rod and a chamber in which the piston slides, the rod cylinder comprising a fastening device for connecting the piston and the ejector so that the movement of the piston in the chamber upon supply of a pressurized fluid effects corresponding movement of the ejector between a standby position and a release position., 'a punch with a cylindrical housing of a predetermined length extending between a sampling end and an opposite installation end, the punch comprising11. The system ...

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03-02-2022 дата публикации

Facing and Quality Control in Microtomy

Номер: US20220034768A1
Принадлежит:

The present disclosure also relates to systems and methods for quality control in histology systems. In some embodiments, a method is provided that includes receiving a tissue block comprising a tissue sample embedded in an embedding material, imaging the tissue block to create a first imaging data of the tissue sample in a tissue section on the tissue block, removing the tissue section from the tissue block, the tissue section comprising a part of the tissue sample, imaging the tissue section to create a second imaging data of the tissue sample in the tissue section, and comparing the first imaging data to the second imaging data to confirm correspondence in the tissue sample in the first imaging data and the second imaging data based on one or more quality control parameters. 1. A method for quality control in histology system comprising:receiving a tissue block comprising a tissue sample embedded in an embedding material;imaging the tissue block, prior to removing one or more tissue sections, to generate a baseline imaging data of the tissue sample;imaging the tissue block to create a first imaging data of the tissue sample in a tissue section of the one or more tissue sections on the tissue block;removing the tissue section from the tissue block, the tissue section comprising a part of the tissue sample;imaging the tissue section to create a second imaging data of the tissue sample in the tissue section;comparing the first imaging data to the second imaging data to confirm correspondence in the tissue sample in the first imaging data and the second imaging data based on one or more quality control parameter; andcomparing the first imaging data, the second imaging data or both to the baseline imaging data.2. The method of claim 1 , wherein the tissue section is non-confirming if there is no correspondence in one or more quality control parameters in the tissue sample in the first imaging data and the second imaging data.3. The method of claim 2 , wherein the one ...

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03-02-2022 дата публикации

Facing and Quality Control in Microtomy

Номер: US20220034769A1
Принадлежит:

The present disclosure relates to systems and methods for tracking and printing within a histology system. In some embodiments, a system is provided that includes an information reader configured to read identifying data associated with a tissue block, a microtome configured to cut one or more tissue sections from the tissue block, one or more slides for receiving the one or more tissue sections, and a printer configured to receive the identifying data and print, after the one or more tissue sections are cut from the tissue block, one or more labels for the one or more slides, the one or more labels comprising information associating the one more tissue sections on the one or more slides with the tissue block. 1. A system comprising:an information reader configured to read identifying data associated with a tissue block;a microtome configured to cut one or more tissue sections from the tissue block;one or more slides for receiving the one or more tissue sections;a printer configured to receive the identifying data and print, after the one or more tissue sections are cut from the tissue block, one or more labels for the one or more slides, the one or more labels comprising information associating the one more tissue sections on the one or more slides with the tissue block; anda visualization system configured to track the one or more tissue sections from the microtome to the one or more slides as the one or more tissue sections are being transferred from the microtome to the one or more slides.2. The system of claim 1 , wherein the visualization system is configured to make a comparison between the one or more tissue sections on the one or more slides with one or more images of the tissue block or the image of the section on a transfer medium.3. The system of claim 2 , wherein the visualization system is configured to make a comparison between the one or more tissue sections on the one or more slides claim 2 , on the tissue block or the transfer medium with a ...

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03-02-2022 дата публикации

SAMPLE PREPARATION FOR DIFFICULT SAMPLE TYPES

Номер: US20220034770A1
Принадлежит:

Devices and methods are provided for collecting and handling difficult sample types. 1. A method of amplifying RNA from a direct blood sample comprising:(a) adding the direct blood sample to a sample buffer,(b) bead beating the sample buffer,(c) extracting the RNA from the sample buffer, and(d) amplifying the RNA.2. The method of claim 1 , wherein steps (b) through (d) are performed in a closed sample vessel.3. The method of claim 1 , wherein steps (a) through (d) are performed without centrifugation claim 1 , ethanol precipitation claim 1 , and DNA digestion.4. The method of claim 1 , wherein the RNA is host RNA.5. The method of claim 1 , wherein the direct blood sample is collected in a RNA stabilized solution.6. The method of claim 1 , wherein the direct blood sample is collected in a non-RNA stabilizing solution.7. The method of claim 1 , wherein the direct blood sample is separated prior to step (a) and a blood fraction is used.8. The method of claim 1 , further comprising filtering the sample between steps (a) and (b).9. The method of claim 1 , wherein the RNA is provided in high copy number.10. The method of claim 1 , wherein the RNA is from microorganisms.11. The method of claim 1 , further comprising washing the RNA following the extracting step claim 1 , wherein the washing step comprises no more than three washes.12. The method of claim 1 , wherein the sample buffer includes a guanidinium compound.13. The method of claim 1 , wherein step (g) includes a first-stage multiplex PCR and a plurality of individual second-stage PCR reactions. This application is a divisional application of U.S. patent application Ser. No. 15/340,612, filed Nov. 1, 2016, which claims the benefit, under 35 U.S.C. § 119(e), of U.S. Provisional Application Ser. No. 62/249,592, filed Nov. 2, 2015, the entire contents of each of which are incorporated by reference herein.Embodiments of the present disclosure relate generally to methods and devices for extracting nucleic acids from a ...

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16-01-2020 дата публикации

TISSUE SAMPLER

Номер: US20200015793A1
Принадлежит:

The invention relates to a tissue sampler for taking samples of tissue from animal's or plants. The tissue sampler is adapted to hold a storage tube in which a tissue sample is to be placed and to hold a magazine comprising one or more collecting devices. Each collecting device comprises a punch for cutting a tissue sampler and a plunger for pushing the tissue sample into the storage tube. The magazine can be moved after each tissue sample is taken so that a fresh collection device is ready to take the next tissue sample. The invention also relates to a magazine comprising a plurality of collecting devices for use with the tissue sampler. 1. A tissue sampler comprising:a storage tube holder adapted in use to accommodate a storage tube for receiving a tissue sample;a magazine housing adapted in use to accommodate a movable collecting device magazine having a plurality of chambers, each chamber being adapted to receive therein a collecting device and being selectively positionable so as to be aligned with the tube holder;a cutting region provided between the tube holder and the magazine housing to accommodate an item from which the tissue sample is to be taken;actuating means adapted to cause the movement of the collecting device from its chamber, through the item to cut a tissue sample from the item, and into a first end of the storage tube.2. The tissue sampler of claim 1 , wherein the magazine housing comprises a front wall claim 1 , a rear wall claim 1 , and a connecting wall and wherein a cutting region aperture is formed in the front wall and extends between the magazine housing and the cutting region claim 1 , and a ram receiving aperture is formed in the rear wall and substantially aligns with the cutting region aperture.3. The tissue sampler of claim 1 , wherein a retractable magazine locator projects into the magazine housing.4. The tissue sampler of claim 1 , wherein a chamber locator is provided within the magazine housing and is adapted to engage with the ...

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21-01-2016 дата публикации

Sample Extraction Apparatus And Method For Liquefaction Assessment

Номер: US20160018307A1
Автор: Kim Chol-Ho
Принадлежит: Hokoku Engineering Co., Ltd.

A sample extraction apparatus for extracting samples from a target ground in order to assess whether liquefaction occurs in the target ground, includes: a casing; a holding sleeve, installed inside the casing, for holding the samples; and a vibrator configured to apply vibration accelerations corresponding to different seismic intensities to the samples in the casing, respectively, after the casing is inserted into the target ground to hold the samples of the target ground in the holding sleeve, so that a different liquefaction condition is provided for each sample, whereby said apparatus is configured such that, after having applied different vibration accelerations to the samples in the casing inserted into the target ground, respectively, said apparatus can resultantly extract the samples so that a liquefaction assessment can be made under a plurality of seismic conditions.

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21-01-2021 дата публикации

PORTABLE ALLERGEN DETECTION SYSTEM

Номер: US20210016269A1
Принадлежит:

The present invention provides systems, devices and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sample pickup, one or more disposables for receiving and processing a test sample and a detection device that can execute an allergen detection testing in minutes. The present detection system and device is compact and portable. 1. A portable allergen detection system comprising:a cup body;a cup lid assembly having a plurality of reaction chambers, at least one port opening into the cup body, and a flow tube with a distal end extending into the cup body;a sampler; anda housing, having a detection device.2. The portable allergen detection system in claim 1 , wherein the at least one port further comprises a food corer port and a rotor port; the food corer port for receiving the sample and the rotor port for receiving a rotor.3. The portable allergen detection system in claim 1 , wherein the cup body is in fluid communication with the detection device.4. The portable allergen detection system in claim 2 , wherein the flow tube is in fluid communication with and between the cup body and the detection device.5. The portable allergen detection system in claim 4 , wherein the flow tube is connected distally to a filter assembly claim 4 , which is in fluid communication with the detection device.6. The portable allergen detection system of claim 1 , wherein the at least one port includes three ports; the three ports comprising a rotor port claim 1 , a food corer port claim 1 , and a test cup port.7. The portable allergen detection system of further comprising a flow controlling component claim 6 , and wherein the test cup port connects the cup body to the flow controlling component.8. The portable allergen detection system of claim 7 , wherein the flow controlling component is within the detection device claim 7 , and wherein the flow controlling component is capable ...

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21-01-2021 дата публикации

REAGENT CARTRIDGE

Номер: US20210016286A1
Автор: Koch Dale, SWANSON Todd
Принадлежит:

In one embodiment, a cartridge includes at least one compartment and a reagent in the at least one compartment. The reagent is a chemical composition for testing at least one of soil and vegetation for a chemical contained in the soil or vegetation. The reagent can be used in a soil and/or vegetation analysis test. The cartridge can contain an authentication chip to ensure that the reagent is the correct reagent for the analysis test. 1. A cartridge comprising:at least one compartment;a reagent in the at least one compartment, wherein the reagent is a chemical composition for testing at least one of soil and vegetation for a chemical contained in the soil or vegetation; andwherein the cartridge is adapted to cooperate with a soil and/or vegetation analysis system to supply the reagent to the soil and/or vegetation analysis system.2. The cartridge of claim 1 , further comprising an authentication device.3. The cartridge of claim 2 , wherein the authentication device comprises a chip adapted to be connected to a network claim 2 , wherein when connected to the network claim 2 , the authentication chip is accessed by the network to confirm that the cartridge is an authorized cartridge containing the reagent that is specific for a soil and/or vegetation test.4. The cartridge of further comprising a meter to measure an amount of reagent dispensed from the cartridge claim 1 , wherein the meter communicates the amount of reagent dispensed from the cartridge to a network.5. (canceled)6. The cartridge of further comprising a counter to count a number of times reagent is dispensed from the cartridge to determine consumed volume of reagent claim 1 , wherein the counter communicates with a network to communicate the number of times.7. The cartridge of further comprising a time counter to count time for determining an amount of reagent dispensed from the cartridge claim 1 , wherein the time counter communicates with a network to communicate the amount of time.8. The cartridge of ...

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17-01-2019 дата публикации

TESTING VESSEL AND TESTING METHOD EMPLOYING SAME

Номер: US20190017903A1
Принадлежит: SEKISUI MEDICAL CO., LTD.

A testing vessel includes a flexible vessel body having a bottom and a hollow shape; and a partition axially extending in the vessel body and dividing an analyte extract containable space in the vessel body 10 into two or more compartments. The testing vessel enables two or more items to be readily tested with two or more test pieces. 1. A testing vessel comprising:a flexible vessel body having a bottom and a hollow shape; anda partition axially extending in the vessel body, the partition dividing an analyte extract containable space in the vessel body into two or more compartments.2. The testing vessel according to claim 1 , wherein the partition is integrated with the vessel body and extends from the bottom of the vessel body.3. The testing vessel according to claim 1 , wherein the analyte extract containable space in the vessel body is divided into three or more compartments.4. The testing vessel according to claim 1 , wherein the partition is detachably mounted to the interior of the vessel body with a locking member.5. The testing vessel according to claim 1 , wherein the partition is a hollow pillar partition extending from the bottom of the vessel body.6. A test kit comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the testing vessel according to , the testing vessel containable an analyte extract; and'}a test piece.7. A testing method comprising:impregnating a swab containing an analyte with an analyte extract in a flexible testing vessel, the vessel having an internal space divided into two or more compartments in the axial direction;squeezing the analyte from the swab by deforming the testing vessel with external force;immersing a first test piece into a first compartment of the testing vessel.8. The testing method according to claim 7 , further comprising immersing a second test piece into a second compartment of the testing vessel.9. The testing method according to claim 8 , wherein the second test piece is immersed substantially ...

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17-01-2019 дата публикации

PROBE WITH SOLID BEVELED TIP AND METHOD FOR USING SAME FOR SPECIMEN EXTRACTION

Номер: US20190017904A1
Автор: Giannuzzi Lucille A.
Принадлежит:

A probe includes a solid elongate body disposed along a long axis of the probe and terminating in a probe tip, and a solid planar beveled surface at or adjacent an end of the probe tip formed at a non-zero beveled angle relative to a normal of the long axis of the probe, The solid planar beveled surface is configured to impart Van der Waal attractive force to a sample surface positioned immediately adjacent the solid beveled surface of the probe so that the sample can be detached from and lifted from the bulk material and transported to a grid for investigation. Various embodiments of the beveled surface are described, including an elliptical probe tip surface beveled between 10 and 45 degrees to the normal to the probe long axis and planar surfaces formed in the sides of the probe body that are parallel to the probe long axis. 1. A method for lift out of a specimen milled upright within a trench of bulk material where the specimen is of a type having specimen edges that may be free from but under attractive force from adjacent trench edges of the trench , the method comprising:providing a solid probe having a first planar beveled surface formed at or adjacent a probe tip thereof, said first planar beveled surface having a non-zero bevel angle relative to a normal to a long axis of the probe, wherein the first planar beveled surface has a greater surface area than a surface area of the specimen edges;positioning the long axis of the probe at a tilt angle between the long axis and a normal to a face of the specimen, wherein the tilt angle and bevel angle are approximately equal;abutting the first planar beveled surface against a face of the specimen within the trench such that Van der Waal forces between the first planar beveled surface and the face of the specimen is substantially greater than the attractive force between the specimen edges and the adjacent trench edges; andlifting the specimen out from the trench with the probe.2. The method of claim 1 , wherein ...

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17-01-2019 дата публикации

Direct specimen collection device and cassette

Номер: US20190017907A1
Автор: Jangbir Sangha
Принадлежит: Laboratory Corp of America Holdings

The present disclosure relates to a specimen collection device comprising ventilation means for drying a collected specimen. The device further comprises a cassette into which the specimen collected is secured to maintain evidentiary chain of cus tody requirements while providing unobstructed access to a collected specimen for automated analysis. Methods of using the device are also provided.

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03-02-2022 дата публикации

TISSUE ANALYSIS

Номер: US20220037140A1
Принадлежит: MICROMASS UK LIMITED

Disclosed herein is a method of analysing a tissue sample. The method comprises identifying one or more regions of interest within the tissue sample based on a tissue stain that has been applied to the tissue sample. Analyte material is then generated from the one or more regions of interest identified based on the tissue stain using a direct surface sampling probe (), which analyte material is then received at a sampling inlet () and passed towards a mass and/or ion mobility spectrometer () for analysis. 1. A method of analysing a tissue sample , the method comprising:identifying one or more regions of interest within the tissue sample based on a tissue stain that has been applied to the tissue sample;generating analyte material from the one or more regions of interest identified based on the tissue stain using a direct surface sampling technique;receiving the generated analyte material at a sampling inlet; andpassing the analyte material towards a mass and/or ion mobility spectrometer for analysis.2. The method of claim 1 , wherein the direct surface sampling technique comprises a desorption process such as desorption electrospray ionisation (“DESI”) claim 1 , a DESI-derived process claim 1 , or laser desorption ionisation (“LDI”).3. The method of claim 1 , wherein the direct surface sampling technique comprises a laser ablation or rapid evaporative ionisation process.4. The method of claim 1 , comprising automatically identifying one or more regions of interest from the stained tissue sample.5. The method of claim 1 , wherein identifying one or more regions of interest within the stained tissue sample based on the tissue staining comprises obtaining an image of the stained tissue sample claim 1 , and processing the image using an algorithm to identify one or more regions of interest.6. The method of claim 1 , wherein the one or more regions of interest are identified using a machine learning algorithm7. The method of claim 1 , wherein the tissue stain is an ...

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