Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 5137. Отображено 100.
07-03-2018 дата публикации

Картридж для определения показателя гемостаза в крови человека

Номер: RU0000177742U1
Автор: Андрей Владимирович Тронин, Татьяна Александровна Середина
Принадлежит: Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН)

Полезная модель относится к медицинской и биологической технике, а именно к вспомогательному оборудованию для исследования показателей гемостаза.Техническими результатами полезной модели является возможность быстрого и высокоточного исследования крови на показатель гемостаза.Технические результаты достигаются тем, что картридж для определения показателя гемостаза в крови человека содержит корпус с размещенными в нем входным портом для приема исследуемого образца крови и соединенными с портом через микрофлюидную систему каналов тремя измерительными камерами, в каждой из которых расположена пара электродов для измерения импеданса в исследуемом образце и индуктор, инициирующий при смешивании с исследуемым образцом его коагуляцию, при этом все камеры имеют одинаковые размеры, тип и количество индуктора в каждой из них одинаковое, а корпус картриджа содержит дополнительный армирующий слой.Заявляемый картридж для определения показателя гемостаза в крови человека технологичен в изготовлении и позволяет оперативно и с высокой точностью проводить исследования. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 177 742 U1 (51) МПК G01N 33/49 (2006.01) G01N 27/403 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК G01N 33/49 (2006.01); G01N 27/403 (2006.01) (21)(22) Заявка: 2017121008, 15.06.2017 (24) Дата начала отсчета срока действия патента: 07.03.2018 Приоритет(ы): (22) Дата подачи заявки: 15.06.2017 (45) Опубликовано: 07.03.2018 Бюл. № 7 U1, 27.08.2009. US 20080297169 A1, 04.12.2008. US 8563325 B1, 22.10.2013. (54) Картридж для определения показателя гемостаза в крови человека (57) Реферат: Полезная модель относится к медицинской и которых расположена пара электродов для биологической технике, а именно к измерения импеданса в исследуемом образце и вспомогательному оборудованию для индуктор, инициирующий при смешивании с исследования показателей гемостаза. исследуемым образцом его коагуляцию, при этом Техническими ...

Подробнее
Номер записи: 1
24-12-2019 дата публикации

Устройство экспресс-диагностики бактерии helicobacter pylori

Номер: RU0000194791U1
Автор: Александр Борисович Матанцев, Розалия Марселевна Нафикова, Юлия Олеговна Уразбахтина
Принадлежит: федеральное государственное бюджетное образовательное учреждение высшего образования "Уфимский государственный авиационный технический университет"

Использование: полезная модель относится к области медицинской техники и может быть применена для быстрой, неинвазивной диагностики бактерии Helicobacter pylori, и касается лечения язвенной болезни желудка и двенадцатиперстной кишки.Технический результат предлагаемого устройства для экспресс-диагностики бактерии Helicobacter pylori - повышение точности измерения за счет применения электрохимического датчика газа, чувствительного к аммиаку.Сущность полезной модели: устройство для экспресс-диагностики бактерии Helicobacter pylori у пациента, включающее датчик газа, чувствительный к аммиаку, отличающееся тем, что дополнительно содержит блок усиления и фильтрации, карту памяти, модуль Wi-fi, вход блока усиления и фильтрации соединен с выходом модуля измерительной камеры, а выход соединен со входом аналогово-цифрового преобразователя, входы и выходы карты памяти и модуля Wi-fi соединены с микроконтроллером, соединенным с устройством ввода, дисплеем и интерфейсом, причем датчик газа, чувствительный к аммиаку, выполнен электрохимическим, подключен к источнику опорного напряжения и к амперометрическому преобразователю. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 194 791 U1 (51) МПК G01N 33/497 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК G01N 33/497 (2019.08) (21)(22) Заявка: 2019117196, 03.06.2019 (24) Дата начала отсчета срока действия патента: Дата регистрации: Приоритет(ы): (22) Дата подачи заявки: 03.06.2019 (45) Опубликовано: 24.12.2019 Бюл. № 36 (54) УСТРОЙСТВО ЭКСПРЕСС-ДИАГНОСТИКИ БАКТЕРИИ HELICOBACTER PYLORI (57) Реферат: Использование: полезная модель относится к чувствительный к аммиаку, отличающееся тем, области медицинской техники и может быть что дополнительно содержит блок усиления и применена для быстрой, неинвазивной фильтрации, карту памяти, модуль Wi-fi, вход диагностики бактерии Helicobacter pylori, и блока усиления и фильтрации соединен с выходом касается лечения язвенной болезни желудка и ...

Подробнее
Номер записи: 2
01-03-2012 дата публикации

Centrifugal separation kit and methods for centrifugal separation using the same

Номер: US20120053041A1
Автор: Hong Kim, Khi-Pyo Ihm
Принадлежит: Glotech Co Ltd

A centrifugal separation kit is used for centrifugally separating whole blood and body fluid, and a method for centrifugal separation using the kit. The centrifugal separation kit is capable of easily extracting a target substance by installing an injector to a centrifugal separation tube and collecting the centrifugally separated target substance with the injector.

Подробнее
Номер записи: 3
12-04-2012 дата публикации

Devices and Process for Separating Plasma From a Blood Sample

Номер: US20120088227A1
Автор: Emad Sarofim, Hans-Peter Wahl, Michael Heinrich, Roger Sandoz, Tomas Gruebl
Принадлежит: Roche Molecular Systems Inc

The present invention pertains to a device for separating plasma from a blood sample comprising a stacked structure which is provided with a first portion including a separating member having a first surface for applying or receiving the blood sample, wherein the separating member is adapted to permit the passage of plasma but to inhibit the passage of cells, and a second portion including an absorptive member for absorbing the plasma, which has a second surface in contact with the separating member for receiving the plasma, wherein the absorptive member is adapted to generate a capillary pressure so as to draw plasma from the separating member to the absorptive member. The first portion is fixed to the backing member in a manner to be removed without destroying the absorptive member. The absorptive member is fixed to the backing member in a manner to be removed without destroying the absorptive member.

Подробнее
Номер записи: 4
17-05-2012 дата публикации

Guided structured testing kit

Номер: US20120122227A1
Автор: Christopher Wiegel, Colleen Csavas, Ulrich Porsch
Принадлежит: Roche Diagnostics Operations Inc

A guided structured testing kit comprising a test strip container, a test strip meter, a testing protocol advisor, and at least one of diagnostic test strip is presented. The diagnostic test strip comprising a support element, a glucose reagent provided on the support element, and a glycemic context code provided on the support element. The glycemic context code can be machine-readable. The glycemic context code signals a glycemic context to a test strip meter, either upon insertion of the diagnostic test strip or by a user manually inputting the glycemic context into the test strip meter. A method for performing a guided structured test is also provided.

Подробнее
Номер записи: 5
14-06-2012 дата публикации

Disease diagnosing biosensor capable of promptly separating blood cells

Номер: US20120145541A1
Автор: Ki Tae Kim, Rak Sun Mok
Принадлежит: Digital Optics Ltd

The present invention relates to a disease diagnosing biosensor capable of promptly separating blood cells, in which a disease can be analyzed further accurately by adding a blood cell separating pad on a front or rear side of a capillary tube and separating the blood cells and plasma within 1 or 2 seconds owing to distribution of hydrophilic and hydrophobic segments. The entire configuration of the biosensor according to the present invention includes a base film; electrodes arranged on a top surface of the base film; a space film covering a top surface of the electrodes; a blood cell separating pad connected to a rear side of the space film; a capillary tube added on a rear top surface of the space film; and a cover film covered on a top surface of the capillary tube and the blood cell separating pad.

Подробнее
Номер записи: 6
29-11-2012 дата публикации

Optical thromboelastography system and method for evaluation of blood coagulation metrics

Номер: US20120301967A1
Автор: Seemantini K. Nadkarni
Принадлежит: General Hospital Corp

Device, method, and computer program product for determining a material parameter of a blood coagulation cascade based on parameters of light diffused at a biofluid sample. In one example, the biofluid sample includes a blood sample. Laser light scattered by the sample is collected by the optical system in reflection and/or transmission mode. An image of the sample in so collected light is formed, and data representing fluctuations of laser speckle intensity with is processed to derive numerical descriptors associated with blood coagulation and fibrinolysis. In a specific case, such numerical descriptors are derived based on temporal dynamic of a viscoelastic characteristic of the blood sample.

Подробнее
Номер записи: 7
14-02-2013 дата публикации

Arrangement for detection of hemolysis

Номер: US20130040333A1
Автор: Mathias Karlsson
Принадлежит: Hemcheck Sweden Ab

The present invention relates to a device for visual detection of hemolysis in a whole blood sample, comprising at least one visible detection compartment and a transfer passage connected to said visible detection compartment, said transfer passage being arranged to permit transfer of a volume of plasma from said sample to said detection compartment and wherein said transfer passage further is arranged with a separation device ( 4 ) for separating plasma from blood cells within said whole blood sample before said plasma reaches the detection compartment, wherein said device is arranged with subpressure means providing a subpressure inside said detection compartment for generating a force urging said volume of plasma to be transferred from said whole blood sample to said detection compartment through said transfer passage and via said separation device.

Подробнее
Номер записи: 8
28-02-2013 дата публикации

System and method for blood separation by microfluidic acoustic focusing

Номер: US20130048565A1
Автор: Jason O. Fiering, Shivshankar Sundaram
Принадлежит: Charles Stark Draper Laboratory Inc

Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.

Подробнее
Номер записи: 9
21-03-2013 дата публикации

Microfluidic device

Номер: US20130071304A1
Автор: Byung Hee Jeon
Принадлежит: Cytogen Inc

A micro-fluidic device includes a filter cabinet, a first filtering unit and a second filtering unit. The filter cabinet includes a first path and a second path branched from the first path. The first path and the second path are formed within the filter cabinet so that a sample containing different kinds of targets can flow through the first path and the second path. The first filtering unit is installed in an upstream portion of the first path to filter the different kinds of targets from the sample, the first filtering unit configured to guide the different kinds of targets toward the second path. The second filtering unit is installed in the second path to receive the different kinds of targets from the first filtering unit and to filter the different kinds of targets on a size-by-size basis.

Подробнее
Номер записи: 10
28-03-2013 дата публикации

Measuring Volume and Constituents of Cells

Номер: US20130077085A1
Автор: Zahniser Michael, Zahniser Russell
Принадлежит: CONSTITUTION MEDICAL, INC.

A method of determining a volume of a platelet includes: (a) illuminating the platelet with incident light at a plurality of illumination wavelengths; (b) obtaining at least one two-dimensional image of the platelet corresponding to each illumination wavelength; (c) for each illumination wavelength, determining a mean optical density and a maximum optical density for the platelet; (d) determining an area of the platelet; (e) for each illumination wavelength, determining a volume of the platelet; (f) for each illumination wavelength, determining an integrated optical density for the platelet; and (g) determining the volume of the platelet based on a weighted combination of the area of the platelet, the volumes of the platelet corresponding to each of the illumination wavelengths, and the integrated optical densities for the platelet corresponding to each of the illumination wavelengths. 1. A method of determining a volume of a red blood cell , the method comprising:(a) illuminating the cell with incident light at a plurality of illumination wavelengths;(b) obtaining at least one two-dimensional image of the cell corresponding to each illumination wavelength;(c) for each illumination wavelength, determining a mean optical density and a maximum optical density for the cell;(d) determining an area of the cell;(e) for each illumination wavelength, determining a volume of the cell based on the area of the cell and the mean optical density and maximum optical density for the cell corresponding to the illumination wavelength;(f) for each illumination wavelength, determining an integrated optical density for the cell based on the area of the cell and the mean optical density for the cell corresponding to the illumination wavelength; and(g) determining the volume of the cell based on a weighted combination of the area of the cell, the volumes of the cell corresponding to each of the illumination wavelengths, and the integrated optical densities for the cell corresponding to ...

Подробнее
Номер записи: 11
09-05-2013 дата публикации

IMAGING VOLUMES WITH ARBITRARY GEOMETRIES IN CONTACT AND NON-CONTACT TOMOGRAPHY

Номер: US20130114069A1
Автор: Madden Karen N., Ntziachristos Vasilis, Ripoll Jorge
Принадлежит:

A method for tomographic imaging of diffuse medium includes directing waves into a diffusive medium, solving a surface-bounded inversion problem by forward field calculations through decomposition of contributions from the multiple reflections from an arbitrary surface within the diffusive medium or outside the diffusive medium into a sum of different orders of reflection up to an arbitrary order, and using contact or non-contact measurements of waves outside said diffusive medium to generate a tomographic image. 138.-. (canceled)39. A method for tomographic imaging of a diffusive medium of an object comprising:(a) administering a fluorescent imaging probe to the object comprising the diffusive medium;(b) directing light waves into the diffusive medium;(c) using a detector to detect an intensity of fluorescent light emitted from multiple points from the diffusive medium by using non-contact measurements of the light waves outside the diffusive medium, where there is a non-diffusive medium between the detector and the diffusive medium; and(d) processing the detected intensity of fluorescent light to generate a tomographic image indicating the quantity of fluorescent imaging probe in a three-dimensional target region within the object.40. The method of claim 39 , wherein the diffusive medium comprises biological tissue.41. The method of claim 40 , wherein the non-diffusive medium comprises air.42. The method of claim 39 , wherein the light waves are continuous wave (CW) light.43. The method of claim 39 , wherein the light waves are near-infrared or infrared light.44. The method of claim 39 , wherein the diffusive medium of the object has volume V bounded by a boundary surface S claim 39 , and wherein step (d) comprises generating the tomographic image by modeling propagation of diffuse photon waves inside the diffusive volume V taking into account the boundary surface S and modeling intensity at the detector located outside the diffusive medium.45. The method of claim ...

Подробнее
Номер записи: 12
23-05-2013 дата публикации

BLOOD CELL COUNTER AND CELL COUNTING METHOD

Номер: US20130125628A1
Автор: FUJII Kozo, Kitagawa Nobuhiro, OGURO Masahiko
Принадлежит: SYSMEX CORPORATION

A blood cell counter comprises a stirrer which stirs a whole blood sample in a sample container by moving the sample container, an aspirator which aspirates the whole blood sample by penetrating a lid of the sample container with an aspiration tube after stirring by the stirrer, a detector which counts the blood cells in the whole blood sample aspirated by the aspirator, and a force applying member which applies a force to the sample container in an upright state after stirring by the stirrer so as to remove the whole blood sample from the lid of the sample container. 1. A blood cell counter comprising:a stirrer which stirs a whole blood sample in a sample container by moving the sample container;an aspirator which aspirates the whole blood sample by penetrating a lid of the sample container with an aspiration tube after stirring by the stirrer;a detector which counts the blood cells in the whole blood sample aspirated by the aspirator; anda force applying member which applies a force to the sample container in an upright state after stirring by the stirrer so as to remove the whole blood sample from the lid of the sample container.2. The blood cell counter of claim 1 , whereinthe force applying member moves the sample container by applying the force to the sample container so as to apply a force to remove the whole blood sample from the lid of the sample container.3. The blood cell counter of claim 2 , whereinthe force applying member moves the sample container in a direction transecting the longitudinal direction of the sample container by applying the force to the sample container.4. The blood cell counter of claim 3 , further comprising:a sample container supporter which supports at least the head in the oscillating state, and the sample container in the upright state; whereinthe force applying member applies the force to the sample container in a direction transecting the longitudinal direction of the sample container while the sample container is supported in ...

Подробнее
Номер записи: 13
06-06-2013 дата публикации

Clot Protection and Detection Algorithm for Activated Clotting Time Testing

Номер: US20130144538A1
Автор: Cheek Daniel, Erickson Lawrence, Huang Trevor, Kanayinkal Tessy, Petersen Craig, Yuan Charlene
Принадлежит: Medtronic, Inc.

Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots. 1. A method of detecting formation of a clot in a sample with a washer moving over a distance through the sample , comprising:a. dividing the distance into a plurality of zones;b. repeatedly measuring a drop time of the washer moving through each zone;c. calculating a clot detection threshold for each zone of the plurality of zones as a product of a scale factor and a sum of the measured drop times for each zone;d. considering formation of the clot to be detected if any of a plurality of criteria based upon the clot detection threshold is met for at least one of the zones.2. The method of claim 1 , further comprising also considering a formation of the clot to be detected if any of a plurality of criteria independent of the clot detection threshold is met.3. The method of claim 1 , further comprising:a. repeating a. to d. over a plurality of periods;b. holding the scale factor equal to a first constant value during an initial period of the plurality of periods; andc. keeping the scale factor at a second constant value, lower than the first constant value, during a subsequent third period of the plurality of periods.4. The method of claim 3 , in which the initial period and the subsequent period are separated by a transition period ...

Подробнее
Номер записи: 14
20-06-2013 дата публикации

DEVICE FOR DETERMINING AND/OR MONITORING FOREIGN STRUCTURES IN A FLUID OR IN A FLUID STREAM, AND METHOD FOR DOING SAME

Номер: US20130155387A1
Автор: Wiktor Christoph
Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

The present invention relates to an apparatus for determining and/or monitoring foreign structures in a fluid or in a fluid flow, in particular blood or bloodstream, having at least one optical monitoring means, at least one ultrasound monitoring means and at least one signal evaluation means, wherein the fluid can be optically monitored at least by means of the optical monitoring means and at least by means of ultrasound by means of the ultrasound monitoring means, and wherein at least one foreign structure, can be recognized in the fluid by the signal evaluation means with reference to the combination of the monitoring signals obtained herefrom, in particular with reference to the comparison of the monitoring signals acquired herefrom and/or can be distinguished from at least one second foreign body structure by means of the signal evaluation means. 1. An apparatus for determining and/or monitoring foreign structures in a fluid or in a fluid flow , in particular blood or bloodstream , is provided with at least one optical monitoring means , at least one ultrasound monitoring means and at least one signal evaluation means , wherein the fluid can be optically monitored at least by means of the optical monitoring means and at least by means of ultrasound by means of the ultrasound monitoring means , and wherein at least one foreign structure , in particular an air bubble and/or a solid body such as a blood clot , can be recognized in the fluid by means of the signal evaluation means with reference to the combination of the monitoring signal obtained herefrom , in particular with reference to the comparison of monitoring signals acquired herefrom and/or can be distinguished from at least one second foreign body structure by means of the signal evaluation means.2. An apparatus in accordance with claim 1 , characterized in that one or more air bubbles in the fluid can be recognized in the fluid by means of the signal evaluation means when at least the ultrasound ...

Подробнее
Номер записи: 15
04-07-2013 дата публикации

METHOD FOR RAPID IMAGING OF BIOLOGIC FLUID SAMPLES

Номер: US20130169948A1
Автор: Herzog David, Verrant John, Xie Min A.
Принадлежит: ABBOTT POINT OF CARE, INC.

A method for analyzing a biologic fluid sample is provided. The method includes the steps of: a) disposing the biologic fluid sample within a chamber; b) imaging the biologic fluid sample at a first resolution, and producing first image signals representative of a low resolution image of the sample; c) analyzing the first image signals to identify one or more first characteristics of the sample, and determining a position of each first characteristic within the chamber using a map of the chamber; d) imaging a portion of the biologic fluid sample at a second resolution and producing second image signals, which portion of the sample is determined using the first characteristics and the map, and wherein the second resolution is greater than the first resolution; and e) analyzing the biologic fluid sample using the second image signals. 1. A method for analyzing a biologic fluid sample , comprising the steps of:disposing the biologic fluid sample within a chamber adapted to quiescently hold the biologic fluid sample;imaging the biologic fluid sample at a first resolution, and producing first image signals representative of a low resolution image of the sample;analyzing the first image signals to identify one or more first characteristics of the sample, and determining a position of each first characteristic within the chamber using a map of the chamber;imaging a portion of the biologic fluid sample at a second resolution and producing second image signals representative of a high resolution image of the sample, which portion of the biologic fluid sample is determined using the one or more first characteristics and the map, and wherein the second resolution is greater than the first resolution; andanalyzing the biologic fluid sample using the second image signals.2. The method of claim 1 , wherein the chamber includes a first planar member and a second planar member claim 1 , and the first characteristics of the sample include lateral perimeters of the sample quiescently ...

Подробнее
Номер записи: 16
04-07-2013 дата публикации

ANALYTE MONITOR

Номер: US20130171028A1
Автор: Gupta Anurag, Shaffer Gerald H.
Принадлежит: Bayer HealthCare LLC

An analyte meter for an analyte test strip includes a light source configured to emit a light having a wavelength substantially similar to the maximum absorption band of Hb, an optics assembly configured to direct the light emitted by the light source to a test strip, and a photodetector configured to quantitatively detect light emanating from the test strip and to generate a signal correlating to an analyte concentration in the test strip. 1. An analyte meter for an analyte test strip , comprising:a housing;a light source in the housing configured to emit a light having a wavelength substantially similar to the maximum absorption band of Hb;an optics assembly configured to direct the light emitted by the light source to a test strip; anda photodetector configured to quantitatively detect light emanating from the test strip and to generate a signal correlating to an analyte concentration in the test strip.2. The analyte meter according to claim 1 , wherein the light source is configured to emit a green light having a wavelength ranging between 525-535 nm.3. The analyte meter according to claim 2 , wherein the green light has a wavelength of 530 nm.4. The analyte meter according to claim 1 , further comprising a refracting element for directing the light to the test strip claim 1 , the refracting element comprising a plurality of lenses.5. The analyte meter according to claim 4 , wherein the plurality of lenses are arranged in an array.6. The analyte meter according to claim 5 , wherein prior to the light reaching the test strip claim 5 , the array of the plurality of lenses is the last surface area through which light travels.7. The analyte meter according to claim 5 , wherein the plurality of lenses in the array of lenses are uniformly spaced apart from one another.8. The analyte meter according to claim 5 , wherein there are more than 10 lenses arranged in the array of lenses.9. The analyte meter according to claim 8 , wherein the number of lenses in the array ...

Подробнее
Номер записи: 17
11-07-2013 дата публикации

METHOD AND APPARATUS FOR DETECTING AND COUNTING PLATELETS INDIVIDUALLY AND IN AGGREGATE CLUMPS

Номер: US20130176551A1
Автор: Lalpuria Niten V., Levine Robert A., Wardlaw Stephen C.
Принадлежит: ABBOTT POINT OF CARE, INC.

A method for enumerating platelets within a blood sample is provided. The method includes the steps of: 1) depositing the sample into a sample container having an analysis chamber adapted to quiescently hold the sample for analysis, and an amount of colorant that platelets absorb and which fluoresces upon exposure to one or more predetermined first wavelengths of light; 2) imaging at least a portion of the sample disposed in the analysis chamber, including producing image signals indicative of fluorescent emissions from the platelets illuminated by first wavelengths of light; 3) identifying the platelets using the image signals; and 4) enumerating individual platelets and clumped platelets within the sample using one or more of fluorescent emissions, area, shape, and granularity. 1. A method for enumerating platelets within a blood sample , comprising the steps of:depositing the sample and an amount of colorant into an analysis chamber, which colorant is absorbed by the platelets and is identifiable upon exposure to one or more predetermined first wavelengths of light;illuminating at least a portion of the sample containing the platelets at the first wavelengths;imaging the at least a portion of the sample, including producing first image signals indicative of the colorant absorbed by the platelets;identifying the platelets using the first image signals; andenumerating the platelets within the sample.2. The method of claim 1 , wherein the colorant absorbed within the platelets fluoresces upon exposure to the one or more predetermined first wavelengths of light claim 1 , and the first image signals are indicative of fluorescent emissions from the platelets.3. The method of claim 1 , wherein during the imaging step claim 1 , the blood sample quiescently resides within the analysis chamber.4. The method of claim 1 , wherein the blood sample is substantially undiluted.5. The method of claim 1 , wherein the blood sample is whole blood.6. The method of claim 1 , wherein ...

Подробнее
Номер записи: 18
01-08-2013 дата публикации

LOW VOLUME ASSAY APPARATUS

Номер: US20130195722A1
Автор: Djennati Nasser, Mitchell Andrew
Принадлежит: BIO AMD HOLDINGS LIMITED

Apparatus () for determining a property of a sample. The apparatus has a chamber () for receiving at least a part of the sample and contains a rotor () adapted to rotate within the chamber (). The apparatus () also has a space () between the rotor () and the chamber () which may be at least partially occupied by the sample, driving means () for rotating the rotor (), and a detector () arranged to detect the rate of rotation of the rotor (). The apparatus may also have two parts, a sample strip () for receiving the sample and a receiving member () for receiving the sample strip () and carrying out measurements on the sample. The rotor () may be magnetised across its diameter. The driving means () may be a magnetic driving means. The sample may be a blood sample. The property to be determined by the sample may be the prothrombin time of the blood or plasma. 1. Apparatus for determining a property of a sample comprising a chamber for receiving at least a part of the sample , a rotor that is contained within the chamber and adapted to rotate about an axis , a space between the rotor and the chamber which may be at least partially occupied by the sample , a conduit that leads to the chamber and enables the chamber to be filled with the sample , a driving means adapted to drive the rotor , and a detector arranged to measure the rate of rotation of the rotor within the chamber.2. Apparatus as claimed in claim 1 , comprising a sample strip and a receiving member for receiving the sample strip claim 1 , wherein the sample strip comprises the chamber.3. (canceled)4. (canceled)5. Apparatus as claimed in claim 1 , wherein there are two chambers and respective rotors within each chamber.6. Apparatus as claimed in claim 5 , wherein there is a respective detector associated with each chamber.7. Apparatus as claimed in claim 5 , wherein there is a driving means associated with each chamber.8. Apparatus as claimed in claim 5 , wherein the two chambers are substantially adjacent one ...

Подробнее
Номер записи: 19
08-08-2013 дата публикации

AUTOMATED PLATELET FUNCTION ANALYZER AND ITS ANALYTICAL METHODS

Номер: US20130203175A1
Автор: Cao Ning, Dong Ziquan, Li Xiang, Xu Xin, Yang Weijie, YU Fan
Принадлежит: SINNOWA MEDICAL SCIENCE & TECHNOLOGY CO., LTD.

An automated platelet function analyzer includes a sampling vessel, a preparation vessel, an analysis vessel, a sampling needle, a blood sample syringe, a platelet agonist syringe, an analysis solution syringe and a blood mixing device. A method for platelet analysis is also disclosed. 1. An automated platelet function analyzer comprising:a sampling vessel, a preparation vessel, an analysis vessel, a sampling needle, a blood sample syringe, a platelet agonist syringe, an analysis solution syringe and a blood mixing device;the sampling vessel is used to store blood samples;the preparation vessel is used for a first blood sample dilution;the analysis vessel is used for a second blood sample dilution and a platelet number measure;the blood mixing device is used for mixing the blood samples in the sampling vessel, the preparation vessel and the analysis vessel;the platelet agonist syringe is connected with a platelet agonist storage container so as to dispense platelet agonist into the sampling vessel;the analysis solution syringe is connected with an analysis solution storage container so as to dispense the analysis solution into the preparation vessel or the analysis vessel;the sampling needle, the blood sample syringe, the platelet agonist syringe and the analysis solution syringe are driven by motors separately;the sampling needle is connected to the blood sample syringe and the analysis solution syringe through pipes and valves respectively;as the blood sample syringe is connected to the sampling needle, in sequence transferring the blood samples to the sampling vessel, absorbing the partial blood sample from the sampling vessel and transferring the partial blood sample to the preparation vessel; absorbing the diluted blood sample from the preparation vessel and transferring the diluted blood sample to the analysis vessel; andafter the analysis solution syringe is connected to the sampling needle, the sampling needle will be cleaned.2. The automated platelet ...

Подробнее
Номер записи: 20
29-08-2013 дата публикации

Novel Glucose Tolerance Test and Composition for Use

Номер: US20130219987A1
Автор: Hageman Robert Johan Joseph, Lansink Mirian, van Helvoort Adrianus Lambertus Bertholdus, van Norren Klaske
Принадлежит: N.V. NUTRICIA

The present invention relates to a liquid nutritional composition, to a liquid nutritional composition for use in a diagnostic method for screening of a glucose-intolerant condition, to a kit for screening of a glucose-intolerant condition, and to a diagnostic method for screening a mammal for a glucose-intolerant condition. Furthermore, it refers to a liquid nutritional composition for use as a standard reference nutrition, such as for classification of postprandial glucose responses of different nutritional compositions. The liquid nutritional composition comprises protein, fat, digestible carbohydrate and dietary fibre, wherein the digestible carbohydrate comprises at least 90 weight % of glucose units, based on total digestible carbohydrate mass and preferably is substantially free of fructose. 1. A liquid nutritional composition for use in a diagnostic method for screening a mammal for a glucose-intolerant condition , wherein the glucose-intolerant condition is selected from the group consisting of pre-diabetic conditions and diabetic conditions , the composition comprising , based on the total dry weight of the nutritional composition , 10 to 30 weight % protein , 10 to 30 weight % fat , 40 to 80 weight % digestible carbohydrate and 1 to 8 weight % dietary fibre , wherein the digestible carbohydrate comprises at least 90 weight % of glucose units , based on total digestible carbohydrate mass.2. (canceled)3. Liquid nutritional composition according to claim 1 , wherein the screening comprises measuring the glucose level claim 1 , the triglyceride level claim 1 , the gastrointestinal incretin hormones level claim 1 , the insulin level claim 1 , the lactate level claim 1 , pH claim 1 , the bicarbonate level claim 1 , ketone bodies claim 1 , carbon dioxide or any combination thereof.4. Liquid nutritional composition according to claim 3 , wherein the screening comprises measuring one or more of the glucose level claim 3 , the triglyceride level and the ...

Подробнее
Номер записи: 21
10-10-2013 дата публикации

CENTRIFUGE

Номер: US20130265417A1
Автор: Browne Andrew W., Papu Joseph T., Rust Michael
Принадлежит:

A centrifuge is provided. The centrifuge includes a power source, the power source configured to generate electrical power from a renewable power source. At least one battery electrically coupled to the power source. A motor is electrically coupled to the at least one battery. A rotor is coupled to the motor. The rotor has a generally cylindrical body and a pair of opposing openings opposite the motor, and a pair of holders each disposed in one of the pair of opposing openings, each of the holders having an opening on one end sized to receive a capillary tube. 1. A centrifuge comprising:a power source configured to generate electrical power from a renewable power source;at least one battery electrically coupled to the power source;a motor electrically coupled to the at least one battery; anda rotor coupled to the motor, the rotor having a generally cylindrical body and a pair of opposing openings opposite the motor, and a pair of holders each disposed in one of the pair of opposing openings, each of the pair of holders having an opening on one end sized to receive a capillary tube.2. The centrifuge of wherein the power source is a solar panel.3. The centrifuge of wherein the solar panel includes five 1000 mA claim 2 , 0.55W solar panels.4. The centrifuge of wherein the pair of opposing openings are disposed on an angle.5. The centrifuge of wherein the angle is 65 degrees from a horizontal plane.6. The centrifuge of wherein the at least one battery includes a first battery and a second battery electrically coupled in parallel between the power source and the motor.7. The centrifuge of further comprising a controller configured to selectively couple the first battery to the motor.8. The centrifuge of wherein the controller is configured to charge the second battery with the power source when the first battery is coupled to the motor.9. A method of evaluating a patient's hematocrit comprising:separating a sample of blood in a capillary tube into a red blood cell ...

Подробнее
Номер записи: 22
17-10-2013 дата публикации

Device for performing a diagnostic test and methods for use thereof

Номер: US20130273528A1
Автор: Joel R. L. Ehrenkranz
Принадлежит: Joel R. L. Ehrenkranz

Assay cassettes and testing devices that can be used to provide rapid, accurate, affordable, laboratory-quality testing at the point of care. Such assay cassettes and testing devices are designed to provide rapid, quantitative test results in a point-of-care setting or the like. Likewise, such assay cassettes and testing devices may eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such testing device may include automated data reporting and decision support. Methods for performing point of care diagnostic tests are also disclosed.

Подробнее
Номер записи: 23
24-10-2013 дата публикации

FLUIDS TESTING APPARATUS AND METHODS OF USE

Номер: US20130276521A1
Автор: Cohen Eyal, Fuerst Oren, Oppenheim Dov, Plevinski Meir, WEINTRAUB David
Принадлежит: Labstyle Innovation Ltd.

The invention is directed to a mobile hand held miniature laboratory system in general, and to fluid testing apparatus for performing a parameter measurement in a fluid sample and methods of use thereof in particular. The apparatus comprising: A strip adapted to absorb a fluid sample and to produce a signal indicative of said parameter level in said sample; and an adaptor adapted to connect said strip to a smart phone to thereby allow delivery of the produced signal or a correlated signal to said smart phone for obtaining a measurement of said fluid parameter displayed on said smart phone, wherein said testing apparatus relies on said smart phone at least for power supply and display means. 150-. (canceled)51. A fluid testing apparatus for performing a parameter measurement in a fluid sample comprising:a. a strip adapted to absorb a fluid sample and to produce a signal indicative of said parameter level in said sample; andb. an adaptor adapted to connect said strip to a mobile device to thereby allow delivery of the produced signal or a correlated signal to said mobile device for obtaining a measurement of said fluid parameter displayed on said mobile device, wherein said testing apparatus is adapted to obtain at least a display means from said mobile device.52. The fluid testing apparatus according to claim 51 , wherein said fluid testing apparatus is adapted such that at least one of the following is true:a. said produced signal or a correlated signal is processed at least partially by said fluid testing apparatus before delivery to said mobile device; andb. said produced signal or a correlated signal is delivered to said mobile device for processing by a dedicated application software installed on said mobile device.53. The fluid testing apparatus according to claim 52 , wherein said processing is conducted by reading the peak and timing of peak of a current of a voltage signal obtained upon loading the fluid sample on said strip.54. The fluid testing apparatus ...

Подробнее
Номер записи: 24
24-10-2013 дата публикации

Systems and methods for separation and analysis of target analytes

Номер: US20130280146A1
Автор: Jonathan E. LUNDT, Joshua J. NORDBERG, Ronald C. Seubert
Принадлежит: Rarecyte Inc

Systems for analyzing multiple target analytes of a suspension include a tube and multiple floats. The target analytes are conjugated with at least one fluorescent marker, and the tube, multiple floats and suspension are centrifuged so that at least a portion of each target analyte is located between the inner wall of the tube and the surface of the respective float. In order to identify each target analyte, the portions of the suspension between the tube and each float is illuminated with one or more channels of excitation light, which causes the at least one fluorescent marker to become excited and emit light at longer wavelengths. One of the target analytes may be used to assess quality control or may aid in a subsequent analysis or diagnosis.

Подробнее
Номер записи: 25
24-10-2013 дата публикации

DENSITY-BASED SEPARATION OF BIOLOGICAL ANALYTES USING MULTIPHASE SYSTEMS

Номер: US20130280693A1
Автор: Kumar Ashok A., Mace Charles R., Whitesides George M., Wirth Dyann F.
Принадлежит:

The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially. 1. A method of analyzing or separating a sample comprising one or more biological analytes of interest using a multi-phase system , comprising: each phase comprises a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer;', 'each said phase has an upper and a lower phase boundary; and, 'a) providing a multi-phase system comprising two or more phase-separated solutions, wherein'}each of the two or more phases has a different density and the phases, taken together, represent a density gradient; andb) introducing a biological sample comprising one or more biological analytes of interest without disrupting the phase-separated solution; andc) allowing each of the biological analytes to migrate to a location in the multi-phase system that is characteristic of its density, wherein during migration the sample contacts one or more of the two or more phases sequentially.2. The method of claim 1 , wherein the at least two phases share a common solvent.3. The method of wherein the multi-phase system is an aqueous system and the common solvent is an aqueous solvent.4. The method of claim 1 , wherein the multi-phase system is a non-aqueous system and the common solvent is an organic solvent.5. The method of claim 1 , wherein the phase ...

Подробнее
Номер записи: 26
24-10-2013 дата публикации

Closed Loop Blood Glucose Control Algorithm Analysis

Номер: US20130282301A1
Автор: Rush Benjamin Mark
Принадлежит:

Methods and devices to generate a tool for testing, simulating and/or modifying a closed loop control algorithm are provided. Embodiments include receiving glucose data for a predetermined time period, determining a variation in the glucose level based on the received glucose data, filtering a received glucose data based on the determined variation, substituting a negative change in the glucose data value with a predetermined value to generate a sequence of modified glucose values, and integrating the sequence of modified glucose values to determine an uncontrolled blood glucose excursion condition. 1. A method , comprising:receiving glucose data for a predetermined time period;determining a variation in the glucose level based on the received glucose data;filtering the received glucose data based on the determined variation;substituting a negative change in the glucose data value with a predetermined value to generate a sequence of modified glucose values; andintegrating the sequence of modified glucose values to determine an uncontrolled blood glucose excursion condition.2. The method of wherein the predetermined value includes an average value.3. The method of wherein the average value includes an average of ten prior values.4. The method of wherein the average value includes a weighted average value.5. The method of wherein the weighed average value includes an equally weighted average value.6. The method of wherein the weighed average value includes an unequally weighted average value.7. The method of wherein the average value includes an unweighted average value.8. The method of wherein filtering based on the predetermined variation includes filtering out glucose values associated with a negative change.9. The method of wherein the negative change is determined based on an immediate prior glucose value.10. An apparatus claim 8 , comprising:a user interface;one or more processors operatively coupled to the data user interface; anda memory for storing ...

Подробнее
Номер записи: 27
07-11-2013 дата публикации

Apparatus and method for the automated detection of phases for automated analysis

Номер: US20130292587A1
Автор: Daniel Frayssinhes, Yves Loire
Принадлежит: CYBIO FRANCE SARL

An apparatus and a method are provided for the detection of the level of the different phases present in at least one tube or vessel intended for filling the different wells of a microplate-format container for an automated analysis system. The apparatus is equipped with a fixing portion arranged to allow it to be itself held and/or handled instead of a microplate-format container, and carries out this detection by measuring the variation in wavelength of light reflected on a point zone of the content of the tube, during a displacement of the tube along an optical reader or of the optical reader along the tube in a rectilinear movement in a known manner. Such a device or method is also operated by illumination with monochromatic light and detection of the amount of reflected light, with the phase differences being recognized by the sudden variation in the amount of reflected light.

Подробнее
Номер записи: 28
21-11-2013 дата публикации

Method of measuring bleeding volume

Номер: US20130310672A1
Автор: Jeffrey A. Klein
Принадлежит: Individual

A method of measuring blood clotting ability of a patient. A known volume of blood is dispensed on a reference disc of blotter paper, such that at least one reference blotch is formed on the reference disc. The surface area of the reference blotch formed on the reference disc, such that a relationship between the volume of blood and the surface area of the reference blotch can be obtained. An incision is made at the patient. A piece of blotter paper to the incision is applied to the incision to collect blood flowing therefrom, such that at least one blotch is formed on the piece of blotter paper. The surface area of the blotch formed on the piece of blotter paper is measured. The volume of the blood absorbed blood by the blotter paper is calculated according to the relationship between the blood volume and the surface area of the blotch.

Подробнее
Номер записи: 29
05-12-2013 дата публикации

APPARATUS AND METHOD FOR ISOLATING LEUKOCYTES AND TUMOR CELLS BY FILTRATION

Номер: US20130323711A1
Автор: HESTER KELLY D., Liu Xinjun, Singh Sharat
Принадлежит:

The present invention provides novel apparatuses and methods for isolating or recovering a subset of blood cells such as leukocytes and/or circulating tumor cells from blood samples by filtration without changing the intracellular concentration of a therapeutic agent such as an anticancer drug. Contrary to the art, the apparatuses and methods of the present invention advantageously provide cell lysates from recovered cells such as leukocytes and/or circulating tumor cells without substantial dilution of a therapeutic agent such as an anticancer drug. 1. An apparatus for isolating and separating leukocytes from red blood cells in a whole blood sample , said apparatus comprising:a filtration device comprising an upper chamber, a lower chamber, and one or more stacked filter membranes between said upper and lower chambers, wherein said one or more stacked filter membranes are capable of retaining said leukocytes; anda collection tube for collecting red blood cells from said whole blood sample, wherein said filtration device is placed on top of said collection tube, and wherein said red blood cells are separated from said leukocytes and collected in said collection tube following centrifugation.2. The apparatus of claim 1 , wherein said whole blood sample is loaded into said upper chamber of said filtration device.3. The apparatus of claim 1 , wherein said filtration device comprises two claim 1 , three claim 1 , or four stacked filter membranes.4. The apparatus of claim 1 , wherein said upper chamber further comprises a snap-cap lid attached thereto.5. The apparatus of claim 1 , further comprising a second collection tube claim 1 , wherein said collection tube containing said red blood cells is replaced with said second collection tube following centrifugation.6. The apparatus of claim 5 , wherein a lysate of said leukocytes is collected in said second collection tube following the addition of lysis buffer to said upper chamber and centrifugation.7. The apparatus of ...

Подробнее
Номер записи: 30
12-12-2013 дата публикации

BIOMARKERS USEFUL FOR DIAGNOSING PROSTATE CANCER, AND METHODS THEREOF

Номер: US20130330746A1
Автор: Bingham Erin, Ritchie Shawn
Принадлежит: PHENOMENOME DISCOVERIES INC.

The present invention describes a method for predicting a health-state indicative of the presence of prostate cancer. The method measures the intensities of specific small biochemicals, called metabolites, in a blood sample from a patient with an undetermined health-state, and compares these intensities to the intensities observed in a population of healthy individuals and/or to the intensities previously observed in a population of confirmed prostate cancer-positive individuals. The method enables a practitioner to determine the probability that a screened patient is positive for prostate cancer. 1. A method for determining a change in prostate cancer in a patient , the method comprising the steps of:a) analyzing at least one blood sample from said patient by high resolution mass spectrometry to obtain accurate mass intensity data;b) comparing the accurate mass intensity data to corresponding data obtained from one or more than one reference blood sample to identify an increase or decrease in accurate mass intensity; andc) using said increase or decrease in accurate mass intensity to determine change in prostate cancer in said patient,wherein the accurate mass intensity is measured at one or more of the following hydrogen and electron adjusted accurate masses or neutral accurate masses, in Daltons, ±5 ppm,wherein the hydrogen and electron adjusted accurate masses or neutral accurate masses at which intensity decreases are: 174.1408, 188.1566, 194.0804, 232.9133, 242.2251, 252.2096, 258.2482, 268.2412, 272.2357, 276.2096, 278.2256, 279.2287, 280.2414, 281.2448, 283.2602, 292.204, 296.2358, 298.2519, 299.2558, 300.2098, 300.2676, 302.2256, 304.2394, 304.241, 305.243, 305.2439, 306.257, 308.2715, 310.2154, 310.2884, 312.2313, 312.304, 314.2464, 320.2358, 326.2262, 327.0326, 329.2426, 329.2445, 330.2568, 340.2977, 342.2198, 368.3437, 369.3474, 371.3538, 392.294, 411.3186, 430.3083, 430.3818, 431.3861, 432.3686, 452.2536, 481.3171, 481.3172, 482.3216, 484.3792, 492.4184 ...

Подробнее
Номер записи: 31
19-12-2013 дата публикации

Process for Predicting Hematocrit of Whole Blood Using IR Light

Номер: US20130334420A1
Автор: Kusters Benjamin, Min Kyungyoon, Wegener Christopher
Принадлежит: Fenwal, Inc.

A separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, including prediction of the hematocrit of the whole blood using a light source and an optical sensor. 1. In a blood processing procedure in which blood is processed into one or more blood components with a single-use processing kit , the processing kit including tubing through which the blood is flowed , and a reusable hardware module onto which the processing kit is mounted , the reusable hardware module including a sensing field defined by an infrared light source and an infrared reflectance sensor that receives a segment of the tubing , a method for predicting the hematocrit of the blood comprising:loading the processing kit onto the hardware module with a segment of the tubing positioned in the sensing field defined by the infrared light source and the infrared reflectance sensor;obtaining an infrared reflectance measurement of the segment of the tubing with either no fluid or a non-reflecting fluid within said segment;flowing blood through the segment of the tubing;obtaining an infrared reflectance measurement of the segment of the tubing with said blood;deriving the natural log of the infrared reflectance measurement attributable to the presence of blood in the segment of the tubing;inputting the natural log of the infrared reflectance attributable to the blood in the segment of the tubing into a correlation equation to arrive at the hematocrit of the blood;outputting the predicted hematocrit of the blood.2. The method of further comprising a method for creating the correlation equation for a processing kit comprising:separately flowing a plurality of samples of blood through the segment of the tubing of the ...

Подробнее
Номер записи: 32
16-01-2014 дата публикации

ERYTHROCYTE MECHANICAL FRAGILITY TEST

Номер: US20140017718A1
Автор: Alfano Kenneth, Chakraborty Sumita, Tarasev Michael
Принадлежит: BLAZE MEDICAL DEVICES, LLC

A test for erythrocyte membrane mechanical fragility, involving subjection of a sample comprising red blood cells to a mechanical stress capable of causing hemolysis, and measurement of the hemolysis present after particular extent(s) of the stress. Measurement of hemolysis can be without component separation, such as by cell-counting (optical or non-optical) or by spectral differentiation between cell-free and intracellular hemoglobin. Such tests can incorporate a disposable single-use component that contains an RBC sample during testing, and for certain embodiments the mechanical stress involved comprises (higher-energy) ultrasonic stress. 1. A method for assessing quality of specific units of stored blood product , comprising:subjecting a sample containing red blood cells from a specific unit of blood product to at least one kind of mechanical stress to at least one degree of said stress, thereby causing hemolysis of at least a portion of said cells, whereby said at least one kind of mechanical stress to at least one degree of said stress comprises one or more set(s) of stress condition(s);evaluating how much hemolysis occurs under one or more of said set(s) of stress condition(s), thereby determining a fraction of cells that are hemolysed upon respective set(s) of stress condition(s); andgenerating a representation of quality for said blood product, said representation of quality based at least partly on red blood cell mechanical fragility as reflected by said fraction;wherein the subjecting and evaluating steps are both performed via an integrated system that does not require the manual transfer of said sample between said steps.2. A multiparameter method for characterizing patient or stored blood , comprising:subjecting a sample containing red blood cells to at least one kind of mechanical stress, thereby causing hemolysis of at least a portion of said cells, wherein said stress is applied at two or more degrees of stress intensity and two or more degrees of ...

Подробнее
Номер записи: 33
13-02-2014 дата публикации

ANALYSIS SYSTEM HAVING A MEASUREMENT DEVICE AND TEST ELEMENT

Номер: US20140041443A1
Автор: Eikmeier Heino, Haar Hans-Peter, HOENES Joachim, Horn Carina, Rieger Ewald
Принадлежит: ROCHE DIAGNOSTICS OPERATIONS, INC.

Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device. 1. A portable diagnostic measurement device for determining at least one analytical parameter of a body fluid , in particular for determining an analyte concentration in a body fluid , the device comprising:a housing; anda receiving surface for receiving a test element that is in the form of a carrier strip, wherein the receiving surface is disposed on a narrow side of the housing where an entire narrow side or a section of a narrow side forms the receiving surface such that the test element lies at least partially in a planar manner on the receiving surface.2. The device of claim 1 , wherein the narrow side or the section of the narrow side that forms the receiving surface is raised relative to adjacent or neighboring components of the measurement device and/or has an exposed position.3. The device of claim 1 , wherein the housing member on which the receiving surface is disposed is angled relative to the remaining housing claim 1 , and wherein the angle is in a range of about 30° to about 70°.4. The device of claim 1 , wherein a plane that is spanned by the receiving surface is perpendicular to a device plane or is tilted relative to a perpendicular arrangement by an angle of about 20° to about 70° at a longitudinal axis of the receiving surface towards a front of the measurement device or is tilted away from the front of the measurement device relative to the ...

Подробнее
Номер записи: 34
13-02-2014 дата публикации

Biomarkers used to detect and monitor neurological autoimmune diseases

Номер: US20140045197A1
Автор: Arunakumar Gangaplara, Chandirasegaran Massilamany, Jay Reddy, Robert Powers, Teklab Gebregiworgis, Zsolt Illes
Принадлежит: NuTech Ventures Inc

Biomarkers of neurological autoimmune diseases are described, and methods of using such biomarkers also are described.

Подробнее
Номер записи: 35
27-02-2014 дата публикации

APPARATUS AND METHOD FOR ANALYZING SAMPLE FLUIDS

Номер: US20140057359A1
Автор: Bier Frank, Zahn Dorothea
Принадлежит:

The invention relates to an apparatus and a method for analyzing sample fluids, in particular for analyzing blood samples, for example for the purpose of determining the glucose content, with the same apparatus. A cavity delimited by a carrier tape is hereby positioned above a sensor surface, sample fluid is received in the cavity, at least one value of the sample fluid is measured, the cavity containing the sample fluid is removed from the sensor surface, and a regeneration agent is supplied to the sensor surface by way of the carrier tape. 1214421224022304421404022. Apparatus for analyzing sample fluids , comprising a sensor () for measuring at least one value of the sample fluid () , wherein the sensor () has a sensor surface () via which the measurement can be undertaken , and further comprising a carrier tape () , with which in cooperation with the sensor surface () at least one measuring cell () for receiving sample fluid () is formed or can be formed , wherein at least one regeneration agent for regenerating the sensor () is contained in or on the carrier tape () , wherein the carrier tape () is configured such that the regeneration agent can be applied on the sensor surface ().23022424044. Apparatus for analyzing fluid samples according to claim 1 , wherein the respective measuring cell () is realized by the sensor surface () and a cavity () formed in carrier tape () for receiving the sample fluid ().340. Apparatus for analyzing fluid samples according to claim 1 , wherein the regeneration agent is received in at least one void in the carrier tape ().47080. Apparatus for analyzing fluid samples according to claim 1 , wherein detergents () and/or calibrating agents () as regeneration agents are contained in several voids.540. Apparatus for analyzing fluid samples according claim 1 , wherein the carrier tape () is an endless tape or disk.623424422. Apparatus for analyzing fluid samples according to claim 3 , wherein the apparatus comprises a drive and ...

Подробнее
Номер записи: 36
27-03-2014 дата публикации

Gas equilibrium coil for providing, in real-time, a gas calibrating solution

Номер: US20140083157A1
Автор: Edward J. MULHERN
Принадлежит: Nova Biomedical Corp

A gas-solution equilibrium device for a liquid sample gas analyzer includes a temperature-controlled, thermally-conductive mandrel, a coil of gas-permeable tubing wrapped around the mandrel, the gas-permeable tubing having an inlet and an outlet, and a housing having an internal space containing the temperature-controlled, thermally-conductive mandrel, the coil of gas-permeable tubing and a volume of gas where the gas-permeable tubing has a predefined linear length and a predefined wall thickness, the combination of which together is capable of equilibrating a liquid passing through the coil at a predefined flow rate with oxygen in the atmosphere to provide a gas calibration solution in real time at the outlet of the tubing for the liquid gas analyzer.

Подробнее
Номер записи: 37
27-03-2014 дата публикации

METHOD AND INSERT FOR DENSITY GRADIENT SEPARATION

Номер: US20140087360A1
Автор: Woodside Steven M.
Принадлежит: StemCell Technologies, Inc.

An insert for a centrifuge tube suitable for use in density gradient separation is described. The insert includes a member sized to fit within the tube for dividing the tube into a top portion and a bottom portion. Optionally the insert has a support extending or depending from the member for positioning the member within the tube. At least two openings are located on the member so that a first opening is closer to a bottom end of the tube relative to a second opening when the insert is positioned in the centrifuge tube. Also described are methods for separating a target population of cells from a sample using the insert for a centrifuge tube. 1. An insert for a centrifuge tube , the insert comprising:a member sized to fit within the tube for dividing the tube into a top portion and a bottom portion, andat least two openings through the member so that a first opening is closer to a bottom end of the tube relative to a second opening when the insert is positioned in the centrifuge tube.2. The insert of claim 1 , wherein the first opening allows fluid communication between a space in the top portion of the tube above the member and a space in the bottom portion of the tube below the member when the insert is positioned in the centrifuge tube and wherein the second opening allows air to escape from the space below the member when the bottom end of the tube is filled with a liquid through the first opening.3. (canceled)4. The insert of claim 1 , wherein the at least two openings are sized to provide surface tension across the openings to prevent a liquid contained below the insert to flow through the openings when the tube is inverted.5. The insert of claim 1 , wherein the first opening is located at a lowest part of a top surface of the member when the insert is positioned in the centrifuge tube.6. The insert of claim 1 , wherein the second opening is located at a highest part of a top surface of the member when the insert is positioned in the centrifuge tube.7. The ...

Подробнее
Номер записи: 38
27-03-2014 дата публикации

Isolating Target Cells From A Biological Fluid

Номер: US20140087456A1
Автор: Bhagat Ali Asgar S., Lim Chwee Teck, Tan Swee Jin
Принадлежит: NATIONAL UNIVERSITY OF SINGAPORE

A micro-fluidic device operable to isolate target cells from a biological fluid comprises: an inlet operable to receive the biological fluid, the biological fluid comprising target cells and other components; a waste outlet operable to receive at least the other components of the biological fluid; a plurality of parallel arrays of cell isolation wells coupling the inlet with the waste outlet, each parallel array of cell isolation wells supporting a flow of the biological fluid from the inlet to the waste outlet in response to a pressure differential thereacross, each array of cell isolation wells comprising a plurality isolation wells, each isolation well being dimensioned to mechanically trap the target cells therein whilst permitting flow of other components of the biological fluid; and at least one pressure maintenance structure operable to assist in maintaining a predetermined pressure differential across each of the plurality of parallel arrays of cell isolation wells. 1. A micro-fluidic device operable to isolate target cells from a biological fluid , said micro-fluidic device comprising:an inlet operable to receive said biological fluid, said biological fluid comprising target cells and other components;an waste outlet operable to receive at least said other components of said biological fluid;a plurality of parallel arrays of cell isolation traps coupling said inlet with said waste outlet, each parallel array of cell isolation traps supporting a flow of said biological fluid from said inlet to said waste outlet in response to a pressure differential thereacross, each cell isolation trap being dimensioned to mechanically trap said target cells therein whilst permitting flow of other components of said biological fluid;at least one pressure maintenance structure operable to assist in maintaining a predetermined pressure differential across each of said plurality of parallel arrays of cell isolation traps,a buffer port for reversing the flow through the ...

Подробнее
Номер записи: 39
10-04-2014 дата публикации

PATIENT-BASED RESULTS DISPLAY

Номер: US20140100791A1
Автор: Darmstadt Adam, Forni Theresa, Waite Michael
Принадлежит: Bio-Rad Laboratories, Inc.

A medical testing machine provides improved recall and display of the outcomes of tests performed by the machine. Test outcomes and other information are stored in mass storage directly accessible by the medical testing machine. In one aspect, outcomes of tests relating to a particular patient may be recalled. The system may be especially useful for tests that may be performed multiple times for a particular patient over a period of time, for example testing for HbAlc hemoglobin levels in diabetes patients. According to another aspect, the medical testing machine may store an accession number for each test outcome, and may enable a user to display as a group test outcomes having the same accession number. The system may store further information and associate it with particular test outcomes, for example calibration information. The system may also store a set of rules under which each test instance was run. 1. A medical testing machine , comprising:a testing system for performing a medical test on media sampled from patients, each test instance having an outcome;a reader that obtains, for each of a plurality of test instances, an identifier of the particular patient from which the media was sampled;a processor that causes test outcomes to be stored in a mass storage memory in association with their respective patient identifiers; anda computerized retrieval system that enables a user to specify a particular patient identifier and cause the computerized retrieval system to retrieve from the mass storage memory test outcomes associated with the particular patient identifier.2. The medical testing machine of claim 1 , wherein the reader obtains the identifier by reading it from a container that holds the media.3. The medical testing machine of claim 1 , wherein the media is blood claim 1 , and the test measures the level of HbAlc hemoglobin in the blood.4. The medical testing machine of claim 1 , further comprising an electronic display on which the retrieved outcomes ...

Подробнее
Номер записи: 40
03-01-2019 дата публикации

Procoagulant factors suitable for subsequent autologous use

Номер: US20190000367A1
Автор: Niels Erik Holm, Rasmus Lundquist
Принадлежит: Reapplix AS

Provided is a blood collection unit suitable for accelerated blood coagulation of whole blood for subsequent autologous or allogeneic use. The blood collection unit includes an inside surface that an activation site accelerating coagulation by having a high roughness. Further provided is a blood collection unit including an inside surface that has an activation site having a high roughness area, and an interior of the blood collection unit has been prepared with a pressure of no more than 255 mBar, and preferably a pressure of no more than 130 mBar.

Подробнее
Номер записи: 41
05-01-2017 дата публикации

Device and Method for Separating A Fluid Mixture such as Blood

Номер: US20170003270A1
Автор: Béguin Steve, Déglon Julien, Thomas Aurélien
Принадлежит:

A lab-on-chip device for the processing, in particular the separation, of a fluid mixture comprising two immiscible phases (liquid and/or solid), said device comprising a fluid line () which successively includes an inlet reservoir (), a separation channel (), a collection channel () and an outlet (), said separation channel () being designed in a way as to allow a separation of the fluid mixture into said two phases. 118- (canceled)19. A lab-on-chip device for processing a fluid mixture having two immiscible phases , the device comprising:a fluid line which successively includes an inlet reservoir, a separation channel, a collection channel, and an outlet,wherein the separation channel is configured to allow a separation of the fluid mixture into the two immiscible phases.20. The device according to claim 19 , wherein a size of the separation channel is configured to induce sedimentation and separation of the fluid mixture and generation of a purified fluid by capillary action.21. The device according to claim 19 , further comprising:an air bubble actuator configured to, when actuated, generate an air bubble into the fluid line to isolate a defined volume of processed fluid.22. The device according to claim 19 , the device being configured to generate a purified fluid by capillary driven forces within the separation channel.23. The device according to claim 19 , the device configured to generate a purified fluid by sedimentation within the separation channel.24. The device according to claim 19 , wherein dimensions of the separation channel and wettability of surfaces of the separation channel are configured to allow precise control of a filling speed.25. The device according to claim 19 , wherein dimensions of the separation channel and wettability of surfaces of the separation channel are configured to allow precise control of a shape of a front flow of the fluid mixture.26. The device according to claim 19 , further comprising:a metering channel that ...

Подробнее
Номер записи: 42
04-01-2018 дата публикации

Sensor-Based Systems and Methods for Monitoring Temperature Sensitive Products

Номер: US20180003572A1
Автор: Dubovenko Konstantin, Garsd Emmanuel, Gemmell Zachary, Kuna Jeffrey, Lapin Sergii, Larson Barrett
Принадлежит: Exotag Inc.

A temperature measurement device is provided for monitoring the temperature of a temperature-sensitive product, e.g., a blood product. The temperature measurement device may include multiple different types of temperature sensors, e.g., at least two of the following types of temperature sensors: (a) a product-interfacing temperature sensor in thermal contact with the product, (b) an on-chip temperature sensor of a microprocessor or microcontroller, and/or (c) an ambient temperature sensor configured to measure an ambient temperature external to the product. The temperature measurement device may further include a processor configured to execute computer instructions to receive sensor signals from the multiple types of temperature sensors on the device, determine a product temperature of the product based at least on signals from the multiple temperature sensors, compare the determined product temperature with one or more threshold values, and determine whether to generate a notification based on the results of the comparison. 1. A device for monitoring a temperature of a product , the device comprising:at least one product-interfacing temperature sensor in thermal contact with the product and configured to generate first temperature sensor signals indicating a temperature associated with the product;at least one ambient temperature sensor configured to generate second temperature sensor signals indicating a temperature of an ambient environment in which the product is located;a processor; and receive the first sensor signals generated by the at least one product-interfacing temperature sensor;', 'receive the second sensor signals generated by the at least one ambient temperature sensor;', 'determine a product temperature of the product based at least on (a) the first sensor signals generated by the at least one product-interfacing temperature sensor and (b) the second sensor signals generated by the at least one ambient temperature sensor;', 'identify the existence ...

Подробнее
Номер записи: 43
04-01-2018 дата публикации

NUCLEATED RED BLOOD CELL WARNING METHOD AND DEVICE, AND FLOW CYTOMETER USING THE SAME

Номер: US20180003634A1
Автор: BO Ye, Cheng Qian, HUAN Qi
Принадлежит:

Disclosed are nucleated red blood cell warning devices and methods, and flow cytometers using the same. The devices, methods and flow cytometers can warn whether nucleated red blood cells exist in a blood sample. The warning device may obtain forward-scattered light information, side-scattered light information and fluorescence information when cells in the blood sample pass through a detection region of the flow cytometer. The warning device may generate a side-scattered light-fluorescence dot plot, so as to classify leucocytes into four groups, and may generate a forward-scattered light-fluorescence dot plot, where the forward-scattered light-fluorescence dot plot can include a leucocyte group region. The warning device may obtain a predetermined feature region located at the left side of the leucocyte group region, perform statistics on the amount of characterization cells in the predetermined feature region, and provide a warning when the number of the characterization cells exceeds a threshold value. 1. A nucleated red blood cell warning method for warning whether nucleated red blood cells exist in a blood sample , comprising:acquiring forward-scattered light information, side-scattered light information and fluorescence information when cells in said blood sample pass through a detection region of a flow cytometer;classifying, according to said side-scattered light information and said fluorescence information, leucocytes into at least four groups: lymphocyte population, monocyte population, eosinophil population, and neutrophil and basophil population;generating, according to said forward-scattered light information and said fluorescence information, a forward-scattered light-fluorescence dot plot of said blood sample, wherein said forward-scattered light-fluorescence dot plot comprises a leucocyte population region; andacquiring a predetermined feature region of said forward-scattered light-fluorescence dot plot, performing statistics on an amount of ...

Подробнее
Номер записи: 44
02-01-2020 дата публикации

ELECTRICAL MEASURING CONTAINER, ELECTRICAL MEASURING APPARATUS AND ELECTRICAL MEASURING METHOD

Номер: US20200003793A1
Автор: BRUN MARCAURELE, Hayashi Yoshihito, Katsumoto Yoichi
Принадлежит:

There is provided an electrical measuring container of a biological sample in a liquid phase, including at least a biological sample holding section that accommodates a biological sample in a liquid phase and made of a resin, and an electrical conductive section fixed to the biological sample holding section. In a state in which a portion of the electrical conductive section is buried in the biological sample holding section, the biological sample holding section and the electrical conductive section are integrally formed with each other. 1. An electrical measuring container of a biological sample in a liquid phase , comprising at least:a biological sample holding section configured to accommodate a biological sample in a liquid phase and made of a resin; andan electrical conductive section fixed to the biological sample holding section,wherein, in a state in which a portion of the electrical conductive section is buried in the biological sample holding section, the biological sample holding section and the electrical conductive section are integrally formed with each other.2. The electrical measuring container according to claim 1 , wherein the electrical conductive section is integrated with the biological sample holding section through insert molding.3. The electrical measuring container according to claim 1 , an electrode section configured to come into contact with the biological sample upon measurement, and', 'a connecting section configured to be electrically connected to an external circuit., 'wherein the electrical conductive section includes at least'}4. The electrical measuring container according to claim 3 , further comprising:one or more pairs of the electrode sections.5. The electrical measuring container according to claim 3 , wherein the electrode section is included in a portion of an inner wall of the electrical measuring container.6. The electrical measuring container according to claim 5 , wherein a connecting section of the biological sample ...

Подробнее
Номер записи: 45
07-01-2021 дата публикации

Blood Testing System and Method

Номер: US20210003597A1
Автор: Gorin Michael M., Hillman Robert S., McCluskey Cory Lee, Schwaiger Hubert Martin
Принадлежит:

Some embodiments of a blood coagulation testing system include an analyzer console device and a single-use cartridge component configured to releasably install into the console device. In some embodiments, the blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site. 1. A measuring system for measuring viscoelastic characteristics of a sample liquid , comprising:at least one interface element;at least one shaft rotatably supported by the interface element to be rotated by drive means;a cartridge device fixed to the interface element for holding the sample liquid, the cartridge device having a probe element, the probe element of the cartridge device cooperating with the at least one shaft;at least one detector cooperating with the shaft for measuring viscoelastic characteristics of a portion of the sample liquid in contact with the probe element; anda controller to control the measuring system.2. The measuring system of claim 1 , wherein the cartridge device comprises: at least one testing chamber formed therein, the at least one testing chamber configured for receiving a portion of a sample liquid, and', 'a circumferential wall, the circumferential wall comprising a sample input port defined in the circumferential wall of the at least one testing chamber., 'a cartridge body having3. The measuring system of claim 2 , wherein the probe element is movable within the at least one testing chamber of the cartridge device for measuring viscoelastic characteristics of the sample liquid.4. The measuring system of claim 2 , wherein the cartridge device further comprises:a first cover attached at a first side of the cartridge device, the first cover comprising a first tab and a second tab;a second cover attached at a second side of the cartridge device, opposite to the first side, the second cover comprising a third and fourth tab.5. The measuring system of claim 4 , wherein the ...

Подробнее
Номер записи: 46
20-01-2022 дата публикации

SOLUTION COLLECTION DEVICE WITH EVALUATION ELEMENT

Номер: US20220018827A1
Автор: Deshpande Manish, Samproni Jennifer
Принадлежит: SIEMENS HEALTHCARE DIAGNOSTICS INC.

A blood testing device for detecting hemolysis in a blood sample is described. The blood testing device comprises an housing for containing the blood sample. The housing has a treatment window and an optical zone formed therein. The blood testing device further includes an acoustic transducer positioned to selectively generate acoustic forces directed into the treatment window of the housing and a control unit for selectively actuating and deactuating the acoustic transducer to permit colorimetric analysis of plasma within the blood sample. 1. A blood testing assembly , comprising: a housing constructed of a fluid impermeable material;', 'a treatment window formed in the housing, the treatment window constructed of a material capable of passing acoustic forces into the housing;', 'an optical zone formed in the treatment window of the housing, the optical zone constructed of a material that allows a colorimetric analysis of a blood sample positioned within the housing, and located adjacent to the optical zone; and, 'a blood testing device, comprising an acoustic transducer position to selectively generate acoustic forces directed through the treatment window of the housing and into the blood sample; and', 'a control unit for selectively actuating and deactuating the acoustic transducer., 'a reader, comprising2. A method , comprising:separating blood cells from plasma within a blood sample into a first zone containing plasma and blood cells, and a second zone containing plasma and being substantially devoid of blood cells; andcolorimetrically analyzing the plasma within the second zone to determine a degree of hemolysis within the blood sample. The subject application claims benefit under 35 USC § 119(e) of U.S. provisional Application No. 62/776,825, filed Dec. 7, 2018. The entire contents of the above-referenced patent application are hereby expressly incorporated herein by reference.Not Applicable.Point-of-care testing refers generally to medical testing at or near ...

Подробнее
Номер записи: 47
10-01-2019 дата публикации

SYSTEM AND METHODS FOR MANAGING BLOOD LOSS OF A PATIENT

Номер: US20190008427A1
Автор: MILLER Kevin J, Satish Siddarth, Zandifar Ali
Принадлежит:

One variation of the method for managing blood loss of a patient includes: receiving an image of a physical sample; extracting a feature from an area of the image corresponding to the physical sample; estimating a blood volume indicator of the physical sample according to the extracted feature; estimating a patient blood loss based on the blood volume indicator; estimating a euvolemic patient hematocrit based on an estimated patient blood volume and the estimated patient blood loss; receiving a measured patient hematocrit; and generating a volemic status indicator based on a comparison between the measured patient hematocrit and the estimated euvolemic patient hematocrit. 117-. (canceled)18. A method for managing blood loss of a patient , comprising:tracking a quantity of a fluid administered to the patient intravenously;receiving an image of a physical sample;extracting a feature from an area of the image correlated with the physical sample;estimating a red blood cell content of the physical sample based on the extracted feature;estimating an extracorporeal blood content of the physical sample based on the estimated red blood cell content of the physical sample; andestimating a hematocrit of the patient based on a previous hematocrit of the patient, the quantity of the fluid administered to the patient, and the estimated extracorporeal blood content of the physical sample.19. The method of claim 18 , wherein tracking the quantity of the fluid administered to the patient intravenously comprises tracking the quantity of a known composition administered to the patient according to a transfusion rate claim 18 , wherein estimating hematocrit of the patient comprises estimating the hematocrit of the patient further based on the known composition of the fluid.20. The method of claim 18 , wherein extracting the feature from the area of the image correlated with the physical sample comprises extracting a subset of pixels from a set of pixels within the area of the image.21. ...

Подробнее
Номер записи: 48
14-01-2021 дата публикации

METHODS AND SYSTEMS FOR SEPARATING BIOLOGICAL PARTICLES

Номер: US20210008553A1
Автор: CHEN Yuchao, Mao Pan, Wang Daojing
Принадлежит:

The present disclosure provides methods and systems for separating one or more target analytes from a fluid sample. The systems may comprise a microfluidic device. The microfluidic device may comprise a fluidic channel having an array of obstacles disposed therein. The array of obstacles may be oriented at an angle greater than 0° relative to a direction of a fluid flow in the fluidic channel. The array of obstacles may be configured to separate the target analytes from the fluid upon flow of the fluid through the fluidic channel. The methods of the present disclosure may comprise separating target analytes from a fluid using a microfluidic device comprising obstacles disposed in a fluidic channel of the device. The target analytes may be separated with a high efficiency, sensitivity and/or specificity. 150-. (canceled)51. A microfluidic device , comprising:a fluidic channel; andan array of obstacles disposed in said fluidic channel, and oriented at an angle greater than 0° relative to a direction of a fluid flow in said fluidic channel,wherein an obstacle of said array of obstacles is oriented at an angle of less than 90° with respect to a surface of said obstacles, and wherein said array of obstacles is configured to separate one or more target analytes from a fluid flowing through said fluidic channel.52. The microfluidic device of claim 51 , wherein said array of obstacles is oriented at an angle between about 5° and 30° relative to said direction of said fluidic flow.53. The microfluidic device of claim 51 , wherein a distance between said array of obstacles and a side wall of said fluidic channel increases along said direction of said fluid flow.54. The microfluidic device of claim 51 , wherein individual obstacles of said array of obstacles have a quadrilateral cross-section.55. The microfluidic device of claim 54 , wherein said quadrilateral cross-section is a parallelogram cross-section.56. The microfluidic device of claim 51 , wherein each obstacle of said ...

Подробнее
Номер записи: 49
12-01-2017 дата публикации

AUTOMATIC ANALYZER

Номер: US20170010294A1
Автор: Mori Takamichi, MURAMATSU Yoshiki, Nakamura Kazuhiro
Принадлежит:

A pressure sensor detects the inner pressure of a probe at the time of suction of a specimen and a memory stores therein a plurality of clogging detection parameters in accordance with pressure in the vacuum blood collection tube. The clogging detection parameter stored in the memory is selected in accordance with the pressure in the vacuum blood collection tube, and a determination of the clogging of the probe is performed based on the selected clogging detection parameter and the inner pressure at the time of suction of the specimen detected in the pressure sensor. 1. An automatic analyzer comprising:a probe passing through a cap of a capped vacuum blood collection tube, sucking a specimen inside the vacuum blood collection tube, and discharging the specimen into a reaction cuvette;a syringe causing the probe to suck and discharge the specimen;a dispensation flow path connecting the syringe;a pressure sensor arranged in the dispensation flow path and detecting inner pressure of the probe at time of suction of the specimen;a memory having stored therein a plurality of clogging detection parameters in accordance with pressure in the vacuum blood collection tube for a same suction amount of the specimen; anda controller selecting the clogging detection parameter stored in the memory in accordance with the pressure in the vacuum blood collection tube and performing clogging determination of the probe based on the selected clogging detection parameter and the inner pressure at the time of suction of the specimen detected in the pressure sensor.2. The automatic analyzer according to claim 1 , wherein the clogging detection parameter is a parameter to be used to calculate a statistical distance between the parameter and the inner pressure claim 1 , andwherein the controller compares the statistical distance with a threshold value to perform the clogging determination of the probe.3. The automatic analyzer according to claim 1 , wherein the controller measures the ...

Подробнее
Номер записи: 50
14-01-2021 дата публикации

QUANTIFICATION OF NUCLEOSOME MODIFICATIONS USING CHEMICALLY-DEFINED RECOMBINANT NUCLEOSOMES

Номер: US20210010058A1
Автор: Cowles Martis William, Hall Nathan W., Johnstone Andrea L., Koegh Michael-Christopher, Marunde Matthew R., Sun Zu-Wen, Whelihan Matthew F.
Принадлежит:

The invention relates to the use of recombinant/semi-synthetic nucleosomes carrying histone and/or DNA modifications as a reference standard for quantification of covalently modified (on the histone proteins or wrapping DNA), variant, or mutant nucleosomes (collectively “modified nucleosomes” or “nucleosome modifications”) from a biological sample. The invention further relates to methods of using the assay to accurately quantify single or combinatorial nucleosome modifications as biomarkers of disease. 133-. (canceled)34. A method of determining the specificity of an affinity reagent for a core histone modification and/or DNA modification target epitope , the method comprising using one or more recombinant nucleosomes carrying one or more histone modification and/or DNA modification , wherein determining the specificity of an affinity reagent comprises:a. preparing one or more recombinant mono- and/or polynucleosome sample comprising nucleosomes carrying the one or more histone modification and/or DNA modification target epitopes;b. providing the recombinant nucleosome sample at a single or various concentrations to create a series of reference standards;c. adding one or more affinity reagent to the recombinant nucleosome reference standards; andd. performing an affinity reagent-based assay to measure the amount of nucleosome modification in the recombinant nucleosome reference standard and using this information to determine the specificity of an affinity reagent.35. The method of claim 34 , wherein the affinity reagent is a detection reagent.36. The method of claim 34 , wherein the affinity reagent is a capture reagent.37. The method of claim 34 , wherein the affinity reagent is an antibody claim 34 , antibody fragment claim 34 , Fab claim 34 , Fab′ claim 34 , F(ab)′ claim 34 , scFv claim 34 , Fv fragment claim 34 , nanobody claim 34 , VHH claim 34 , minimal recognition unit claim 34 , aptamer claim 34 , or non-immunoglobulin scaffold.38. The method of claim 34 , ...

Подробнее
Номер записи: 51
14-01-2016 дата публикации

Glucometer system and method

Номер: US20160011138A1
Автор: Cindy Mason, Justin Lindsay
Принадлежит: Individual

The present application relates to an interactive glucose system that permits a user to customize and efficiently manage glucose levels. The system includes a glucose reader configured to interact with a test strip to generate a voltage representative of a glucose level within a blood sample. The voltage is transmitted to an electronic device to generate a glucose reading. The electronic device is configured to store and display data related to the glucose reading. The electronic device and the reader are independent and detachable from one another. The system permits for the use of multiple users to operate and test glucose levels from a single device.

Подробнее
Номер записи: 52
27-01-2022 дата публикации

ION GENERATION USING MODIFIED WETTED POROUS MATERIALS

Номер: US20220028674A1
Автор: Cooks Robert Graham, Ouyang Zheng
Принадлежит:

The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate. 190-. (canceled)91. A method for analyzing a sample , the method comprising:providing a cartridge configured to hold at least a portion of a porous substrate within a body of the cartridge, and an electrode incorporated into the body of the cartridge such that when the porous substrate is disposed within the cartridge, the electrode connects to the porous substrate;loading a sample onto the porous substrate;activating the electrode once the electrode is in contact with the porous substrate to thereby generate ions of the sample; andanalyzing the ions of the sample.92. The method according to claim 91 , wherein analyzing comprising use of a mass spectrometer and the cartridge is positioned with respect to an inlet of the mass spectrometer so that a tip of the porous substrate is aligned with the inlet of the mass spectrometer.93. The method according to claim 91 , wherein the cartridge further comprises the porous substrate.94. The method according to claim 93 , wherein the porous substrate is paper.95. The method according to claim 94 , wherein the paper is filter paper.96. The method according to claim 93 , wherein the porous substrate is wetted.97. The method according to claim 93 , wherein the porous substrate comprises a sample prior to the porous substrate being loaded into the cartridge.98. The method according to claim 93 , ...

Подробнее
Номер записи: 53
14-01-2021 дата публикации

DROPLET-BASED MICROFLUIDIC RHEOMETER SYSTEM

Номер: US20210010916A1
Автор: Burns Mark A., Li Yunzi, Ward Kevin
Принадлежит:

A droplet-based microfluidic rheometer system and method of use for real-time viscosity monitoring of blood coagulation is disclosed. Droplets of blood samples are generated in a microfluidic rheometer, and the size of the droplets is highly correlated to the sample viscosity. The size of the droplets can be determined optically using an inverted light microscope and a camera or using electrodes. The microfluidic rheometer systems provides viscosity measurements in less than a second and consumes less than 1 μl blood or plasma over an hour period. The viscosity measurements may be displayed and transmitted to the Internet or cloud storage. 1. A microfluidic rheometer system comprising:a data collection and readout device in communication with a converter connected to electrodes, the electrodes operatively connected to a microfluidic rheometer to measure capacitance generated by droplets in the microfluidic rheometer;an oil inlet by which oil enters the microfluidic rheometer, wherein the oil inlet is connected to an oil supply line that is connected to an oil container; andan aqueous inlet by which blood or aqueous solution enters the micrometer, wherein the aqueous inlet is connected to an aqueous supply line that is connected to an aqueous container.2. The microfluidic rheometer system of claim 1 , wherein the microfluidic rheometer further comprises:a constriction downstream of the oil inlet and the aqueous inlet;a downstream channel downstream of the constriction.3. The microfluidic rheometer system of claim 2 , wherein:a width of the oil inlet is one to five times the size of a width of the aqueous;a width of the constriction is less than or equal to the width of the aqueous inlet; anda width of the downstream channel is greater than the width of the constriction but less wide than two times the width of the aqueous inlet.4. The microfluidic rheometer system of claim 1 , wherein at least one of the oil supply line and the aqueous supply line is pressurized.5. ( ...

Подробнее
Номер записи: 54
14-01-2021 дата публикации

METHOD FOR MEASURING AMOUNT OF BLOOD COMPONENT IN BLOOD

Номер: US20210010969A1
Автор: FUJII Takaaki, FUJIWARA Masaki, KUTSUNA Fuminori, TAKAHARA Yoshifumi, YANO Setsuko
Принадлежит:

The present invention provides a method for accurately measuring a blood component despite uneven distribution of blood introduced into a capillary. The measurement method according to the present invention is characterized in that a plurality of electrode systems for measuring the hematocrit are provided in a capillary of a biosensor to measure the hematocrit at different positions in the capillary. By measuring the hematocrit at the plurality of positions in the capillary as described above, the hematocrit can be measured mom accurately despite uneven distribution of blood introduced into the capillary.

Подробнее
Номер записи: 55
14-01-2021 дата публикации

SAMPLE ACQUISITION INFORMATION MANAGEMENT DEVICE, SAMPLE ACQUISITION INFORMATION MANAGEMENT SYSTEM, AND SAMPLE ACQUISITION INFORMATION MANAGEMENT METHOD

Номер: US20210010998A1
Автор: ISHIZAKA Tatsuya, NAKATSUGAWA Haruyasu, YAMASHITA Seiji
Принадлежит: FUJIFILM Corporation

There are provided a sample acquisition information management device, a sample acquisition information management system, and a sample acquisition information management method that allow a subject who is to collect a sample by oneself to reliably perform a sample acquisition operation. Each of the sample acquisition information management device and the sample acquisition information management system includes an image acquisition unit () that acquires an image and a video of a sample acquisition operation of a subject using a sample examination kit, an output unit () that outputs acquisition means information and operation check information, and a processing unit () that determines whether or not the image or the video acquired by the image acquisition unit () corresponds to a correct sample acquisition operation and controls display of the acquisition means information and the operation check information. Further, the sample acquisition information management method uses the sample acquisition information management system. 1. A sample acquisition information management device comprising:an input-output interface configured to acquire at least one of an image or a video of a sample acquisition operation of a subject using a sample examination kit, and output acquisition means information and operation check information; andat least one processor configured to determine whether or not the image or the video acquired by the input-output interface corresponds to a correct sample acquisition operation, and control display of the acquisition means information and the operation check information,wherein the at least one processor is further configured to:control the input-output interface to deliver the acquisition means information according to a request of the subject, stop delivering the acquisition means information in a case where delivery of a predetermined sample acquisition operation of the acquisition means information ends, and deliver the operation check ...

Подробнее
Номер записи: 56
10-01-2019 дата публикации

METHOD OF DETECTING PRESENCE OR ABSENCE OF A CLOT IN A LIQUID SAMPLE ANALYZER

Номер: US20190011429A1
Автор: AAS Flemming, FRISCHAUF Peter Aage, TAAGAARD Michael
Принадлежит: Radiometer Medical APS

The invention relates to a method of detecting a clot in a measurement chamber of a liquid sample analyzer, wherein the liquid sample analyzer comprises at least two analyte sensors, a first analyte sensor, for measuring a first analyte in a liquid sample, and one or more second analyte sensors, for measuring one or more second analytes in the liquid sample in the measurement chamber, the method comprising the steps of, (a) at least partly filling the measurement chamber with a known solution having a composition comprising the first analyte at a pre-determined level, and the second one or more analytes at pre-determined levels, (b) obtaining a first sequence of measurement results by the first analyte sensor, and simultaneously obtaining a second sequence of measurement results by the second, one or more analyte sensors, (c) determining a change of the first sequence of measurement results, (d) determining a change of the second one or more sequence of measurement results, (e) comparing the change of the first sequence of measurement results with the second sequence of measurement results, (f) determining presence or absence of a clot in the measurement chamber based on said comparison. 1. A method of detecting a clot in a measurement chamber of a liquid sample analyzer , wherein the liquid sample analyzer comprises at least two analyte sensors , a first analyte sensor , for measuring a first analyte in a liquid sample , and one or more second analyte sensors , for measuring one or more second analytes in the liquid sample in the measurement chamber , the method comprisinga. at least partly filling the measurement chamber with a known solution having a composition comprising the first analyte at a pre-determined level, and the second one or more analytes at pre-determined levels,b. obtaining a first sequence of measurement results by the first analyte sensor, and simultaneously obtaining a second sequence of measurement results by the second, one or more analyte ...

Подробнее
Номер записи: 57
09-01-2020 дата публикации

ELECTROCHEMICAL OSMOLARITY OR OSMOLALITY SENSOR FOR CLINICAL ASSESSMENT

Номер: US20200011778A1
Автор: Cardinell Brittney, Honikel Mackenzie, LaBelle Jeffrey, Lin Chi, Penman Andrew, Smith Marcus, Youngbar Pierce
Принадлежит:

Osmolality and osmolality sensors and methods utilizing electrochemical impedance to detect changes in impedance to varying salinity concentrations. By way of example, the impedance reported at the specified frequency varies logarithmically with the concentration of sodium chloride subject to the sensor surface. Measurements obtained by the sensors and methods herein are utilized, for example, to differentiate between the clinical stages of dry eye disease (290-316 mOsm/L) to complement the current diagnostic procedures. Blood serum, urinalysis, and saliva also may be tested and the corresponding osmolarity or osmolality level evaluated for indications of a disease or condition. 1. A method for collecting and analyzing osmolarity in a bodily fluid , comprising:contacting an absorbent material on a sensor with said bodily fluid, wherein said sensor comprises a substrate and an electrode operably configured to provide an electrochemical impedance measurement of said bodily fluid, andmeasuring an electrochemical impedance of said bodily fluid to determine osmolarity.2. The method of claim 1 , wherein said bodily fluid is tear fluid.3. The method of claim 2 , further comprising detecting an indication of dry eye claim 2 , wherein dry eye is indicated by a measured osmolarity range of between 290-316 mOsm/L.4. The method of claim 3 , further comprising treating dry eye based on said osmolarity.5. The method of claim 4 , wherein said treating includes one or more of punctal occlusion claim 4 , meibomian gland therapy claim 4 , an ocular anti-inflammatory medication claim 4 , cyclosporine ophthalmic emulsion claim 4 , lifitegrast ophthalmic solution claim 4 , or hydroxypropyl cellulose ophthalmic drops.6salvia. The method of claim 1 , wherein said fluid is or urine.7. A method for analyzing osmolality in a bodily fluid sample claim 1 , comprising measuring an electrochemical impedance of said bodily fluid sample with a device to determine osmolality.8. The method of claim ...

Подробнее
Номер записи: 58
09-01-2020 дата публикации

METHODS OF MEASURING HEMATOCRIT IN FLUIDIC CHANNELS INCLUDING CONDUCTIVITY SENSOR

Номер: US20200011825A1
Автор: Webster James Russell
Принадлежит:

Methods of determining hematocrit in a whole blood sample utilizing a system, the system including a first portion, the first portion including at least one fluid channel; a fluid actuator; an analysis sensor disposed within the fluid channel; a conductivity sensor including two electrodes located no more than 10 mm away from each other and disposed within the fluid channel; and an introducer; a second portion, the second portion including at least one well, the well containing at least one material, wherein one of the first or second portion is moveable with respect to the other, wherein the introducer is configured to obtain at least a portion of the material from the at least one well and deliver it to the fluid channel, and wherein the fluid actuator is configured to move at least a portion of the material in the fluid channel, the method including measuring the resistance over substantially the entire portion of a whole blood sample; and calculating an average hematocrit level of the whole blood sample based on the measured resistance. 1. A device comprising: at least one fluid channel;', 'a fluid actuator;', 'an analysis sensor disposed within the fluid channel;', 'a conductivity sensor comprising two electrodes that are no more than 10 millimeters away from each other disposed within the fluid channel; and', 'an introducer;', 'at least one well, the well containing at least one material,', 'a second portion, the second portion comprising, 'wherein one of the first or second portion is moveable with respect to the other, wherein the introducer is configured to obtain at least a portion of the material from the at least one well and deliver it to the fluid channel, and wherein the fluid actuator is configured to move at least a portion of the material in the fluid channel., 'a first portion, the first portion comprising2. The device according to claim 1 , wherein the analysis sensor is a resonator sensor.3. The device according to claim 2 , wherein the resonant ...

Подробнее
Номер записи: 59
15-01-2015 дата публикации

CARTRIDGE FOR PROCESSING A FLUID

Номер: US20150014185A1
Автор: Evers Toon Hendrik, Neijzen Jacobus Hermanus Maria
Принадлежит:

The invention relates to a cartridge () for processing a fluid comprising (i)a pre-treatment fluidic system with an inlet () via which the fluid can be supplied and at least one primary processing chamber () in which said fluid can be processed; (ii) a post-treatment fluidic system with at least one secondary processing chamber () in which fluid can be processed; (iii) a fluid-treatment element () that is permeable to at least a part oft he fluid and that couples the post-treatment fluidic system to the pre-treatment fluidic system. The fluid-treatment element may particularly be a filter material () integrated into at least one foil (). 17908909901090. A cartridge ( , , , ) for processing a fluid , comprising:{'b': 710', '810', '910', '1010', '711', '712', '811', '812', '911', '912', '913', '1011', '1012', '1013, 'a) a pre-treatment fluidic system comprising an inlet (, , , ) via which the fluid can be supplied and at least one primary detection chamber (, , , , , , , , , ) in which said fluid can be measured;'}{'b': 755', '855', '955', '1055', '1055', '1055, 'i': a,', 'b,', 'c, 'b) a post-treatment fluidic system comprising at least one secondary detection chamber (, , , ) in which fluid can be measured;'}{'b': 701', '801', '901', '1001, 'c) a fluid-treatment element (, , , ) that is permeable to at least a part of the fluid and that couples the post-treatment fluidic system to the pre-treatment fluidic system.'}27908909901090. A method for the processing of a fluid in a cartridge ( claim 1 , claim 1 , claim 1 , ) according to claim 1 , said method comprising the following steps:{'b': 710', '810', '910', '1010, 'a) introducing into the inlet (, , , ) of the cartridge a quantity of the fluid that fills both the pre-treatment fluidic system and the post-treatment fluidic system;'}{'b': 711', '712', '811', '812', '911', '912', '913', '1011', '1012', '1013, 'b) measuring the fluid in the primary detection chamber (, , , , , , , , , ) of the cartridge;'}{'b': 755', ' ...

Подробнее
Номер записи: 60
10-01-2019 дата публикации

METHOD FOR ESTIMATING AN AMOUNT OF ANALYTE IN A FLUID

Номер: US20190012788A1
Автор: COUTARD Jean-Guillaume, CUBIZOLLES Myriam Laure, Pouteau Patrick
Принадлежит:

The invention is a method for estimating the amount of analyte in a fluid sample, and in particular in a bodily fluid. The sample is mixed with a reagent able to form a color indicator in the presence of the analyte. The sample is then illuminated by a light beam produced by a light source; an image sensor forms an image of the beam transmitted by the sample, from which image a concentration of the analyte in the fluid is estimated. The method is intended to be implemented in compact analyzing systems. One targeted application is the determination of the glucose concentration in blood. 1. A method for determining a lysis of particles , the particles lying within a fluid sample , the method comprising:mixing the sample with a lysis reagent, the lysis reagent being configured to lyse some particles;illuminating the sample using a light source configured to emit light toward the sample;acquiring, using an image sensor, an image of light transmitted or reflected by the sample, the image sensor comprising pixels;calculating a lysis indicator from the image, the lysis indicator representing a progress of the lysis of particles in the sample.3. The method of claim 2 , wherein the dispersion term is derived from the variance or the standard deviation of the image acquired by the image sensor.4. The method of claim 1 , wherein two images are acquired by the image sensor at two different times respectively claim 1 , the method further comprising comparing the two images; and wherein the lysis indicator is derived from the comparison of the two images.5. The method of claim 4 , wherein the comparison is performed by calculating a difference between the two images or by calculating a correlation between the two images.6. The method of claim 4 , further comprising forming a comparative image representing a comparison between the two images acquired claim 4 , and calculating a statistical quantity of the comparative image claim 4 , the statistical quantity being for example a ...

Подробнее
Номер записи: 61
19-01-2017 дата публикации

APPARATUS, SYSTEM, AND METHOD FOR COLLECTING A TARGET MATERIAL

Номер: US20170014819A1
Автор: "URen Lance", Seubert Ronald
Принадлежит: RareCyte, Inc.

This disclosure is directed to an apparatus, system and method for retrieving target material from a suspension. A system includes a processing vessel, a displacement fluid, and a tube. The tube includes a funnel, a cannula, and a cavity. The cannula allows for fluid communication between the funnel and the cavity, such that the processing vessel is inserted into the cavity, and the cannula extends into the processing vessel. 1. A system comprising: a first end,', 'a second end comprising an aperture,', 'a biological suspension comprising a target material, and', a funnel comprising a mouth proximal to the first end and an apex distal to the first end,', 'a cavity extending from the aperture in the second end towards the apex of the funnel, and', 'a cannula extending from the apex of the funnel into the cavity; and, 'a collection segment between the first and second ends, the collection segment comprising'}], 'a tube comprising'}a processing vessel comprising a closed end and a displacement fluid having a density greater than a density of the target material,wherein at least a portion of the processing vessel is located within the cavity of the tube, andwherein the cannula extends through the closed end of the processing vessel.2. The system of claim 1 , wherein the displacement fluid is selected from the group consisting of: a solution of colloidal silica particles coated with polyvinylpyrrolidone claim 1 , a polysaccharide solution claim 1 , iodixanol claim 1 , an organic solvent claim 1 , a liquid wax claim 1 , an oil claim 1 , a gas claim 1 , olive oil claim 1 , mineral oil claim 1 , silicone oil claim 1 , immersion oil claim 1 , mineral oil claim 1 , paraffin oil claim 1 , silicon oil claim 1 , fluorosilicone claim 1 , perfluorodecalin claim 1 , perfluoroperhydrophenanthrene claim 1 , perfluorooctylbromide claim 1 , organic solvents claim 1 , 1 claim 1 ,4-Dioxane claim 1 , acetonitrile claim 1 , ethyl acetate claim 1 , tert-butanol claim 1 , cyclohexanone claim ...

Подробнее
Номер записи: 62
03-02-2022 дата публикации

PARTICLE SEPARATING AND MEASURING DEVICE, AND PARTICLE SEPARATING AND MEASURING APPARATUS

Номер: US20220034864A1
Автор: YONETA Masashi
Принадлежит: KYOCERA CORPORATION

A particle separating and measuring device of the present disclosure includes: a first flow path device including a post-separation flow outlet through which a first fluid containing specific particles to be separated flows out; and a second flow path device on which the first flow path device is placed and including a first flow inlet through which the first fluid flows in, the first flow path device in which the post-separation flow outlet is arranged in a lower surface is placed on the second flow path device in which the first flow inlet is arranged in an upper surface of a first region, the post-separation flow outlet and the first flow inlet are connected so as to face each other, and a size of an opening of the first flow inlet is larger than a size of an opening of the post-separation flow outlet. 1. A particle separating and measuring device comprising:a first flow path device having a plate-like shape and including a pre-separation flow inlet through which a fluid flows in that contains specific particles to be separated, a main flow path connected to the pre-separation flow inlet, a plurality of branch flow paths each connected to the main flow path, and a post-separation flow outlet through which a first fluid flows out that contains the specific particles that have been separated; anda second flow path device having a plate-like shape and having a first region on which the first flow path device is placed, and a second region that serves as a measurement region for the specific particles, the second flow path device including a first flow inlet through which the first fluid flows in, a second flow inlet through which a second fluid not containing the specific particles flows in, a first flow path connected to the first flow inlet and through which the first fluid passes, and a second flow path connected to the second flow inlet and through which the second fluid passes, wherein the first flow path and the second flow path are arranged in the second ...

Подробнее
Номер записи: 63
21-01-2021 дата публикации

SYSTEM AND METHOD FOR BLOOD SAMPLE COLLECTION AND PROCESSING

Номер: US20210015414A1
Автор: ADAIR Fiona S., HECKEL Dirk, YANG David L.
Принадлежит:

Blood sample collection and processing system () using a tube () and a holder () is described herein. The tube () includes a plasma separation system () for converting a whole blood sample () into a plasma sample without using centrifugation. The plasma separation system () may comprise a filtration system such as a hollow fiber element (). The tube () is thereafter placed in the holder () for analysis regarding the plasma. The results of the analysis may be displayed to the user via a display screen () to allow the user to determine whether the sample is sufficient for further use. Inasmuch as the analysis system () performs a rapid analysis of the plasma sample, the patient may still be present or in close proximity and if the sample is insufficient, the healthcare provider can take another whole blood sample (), counsel the client regarding the blood sample (), or examine the patient further. 1. A collection system comprising:(a) a tube; and(b) a holder, wherein the holder is configured to receive the tube therein.2. The collection system of claim 1 , wherein the tube comprises a plasma separation system.3. The collection system of claim 2 , wherein the plasma separation system comprises a filtration system.4. The collection system of claim 3 , wherein the filtration system comprises a hollow fiber element.5. The collection system of claim 4 , wherein the hollow fiber element comprises:(a) a filter wall, wherein the filter wall is configured to allow plasma to pass therethrough; and(b) an interior defined by the filter wall, wherein the interior is configured to received whole blood therein.6. The collection system of claim 5 , further comprising a pressure system configured to force whole blood through the filter wall.7. The collection system of claim 1 , wherein the tube defines a collection chamber.8. The collection system of claim 7 , wherein the collection chamber defines an analysis pocket therein.9. The collection system of claim 1 , wherein the holder ...

Подробнее
Номер записи: 64
19-01-2017 дата публикации

Apparatus, systems & methods for non-contact rheological measurements of biological materials

Номер: US20170016878A1
Автор: Damir Khismatullin, Ray Holt
Принадлежит: Tulane University

An acoustical non-contact levitation system and method for eliciting the deformation response of biological samples, coupled with the data analysis to yield quantitative measures of established time-dependent viscoelastic material properties. Embodiments allow for measurement to occur in near-real-time by way of a computer. In use, a biological sample is placed in an acoustic levitator, where it is induced to oscillate, such that material properties of the sample can be observed and analyzed by way of a camera and/or photodiode.

Подробнее
Номер записи: 65
21-01-2016 дата публикации

PARTICLE ANALYSIS APPARATUS

Номер: US20160018314A1
Автор: Hamada Motoaki, Igushi Tatsuo
Принадлежит:

A particle analysis apparatus for flow cytometry, which contains a flow cell having a flow channel for flowing a sample solution containing particles to be analyzed, a light source device for emitting an irradiation light, an optical system for irradiating the irradiation light on an irradiation segment in the flow channel, and a light receiving device for detecting the light obtained thereby. A light source of the light source device is LED, and an electrode formed on a light extraction surface thereof mainly contains a plurality of electric conductor lines arranged in parallel to each other.

Подробнее
Номер записи: 66
21-01-2016 дата публикации

BLOOD CONDITION ANALYZING DEVICE, BLOOD CONDITION ANALYZING SYSTEM, BLOOD CONDITION ANALYZING METHOD, AND BLOOD CONDITION ANALYZING PROGRAM FOR CAUSING COMPUTER TO EXECUTE THE METHOD

Номер: US20160018346A1
Автор: BRUN MARCAURELE, Hayashi Yoshihito, Katsumoto Yoichi
Принадлежит: SONY CORPORATION

There is provided a blood condition analyzing device including an erythrocyte quantitative evaluation unit configured to evaluate a hematocrit value and/or a hemoglobin amount on the basis of an electrical characteristic of a blood sample at a frequency of 2 to 25 MHz. 1. A blood condition analyzing device comprising:an erythrocyte quantitative evaluation unit configured to evaluate a hematocrit value and/or a hemoglobin amount on the basis of an electrical characteristic of a blood sample at a frequency of 2 to 25 MHz.2. A blood condition analyzing device comprising:a blood rouleaux evaluation unit configured to evaluate rouleaux formation of erythrocytes by dividing temporal change data of an electrical characteristic of a blood sample at a prescribed frequency by electrical measurement data of the blood sample at a frequency of 2 to 25 MHz.3. The blood condition analyzing device according to claim 2 , wherein the temporal change data of the electrical characteristic is a difference between an electrical characteristic of the blood sample at a time when rouleaux have proceeded and an electrical characteristic of the blood sample before rouleaux proceed.4. The blood condition analyzing device according to claim 2 , wherein the temporal change data of the electrical characteristic is temporal change data of the electrical characteristic of the blood sample at a frequency of 100 kHz to 40 MHz.5. The blood condition analyzing device according to claim 2 , further comprising:an erythrocyte sedimentation evaluation unit configured to evaluate a degree of erythrocyte sedimentation on the basis of rouleaux formation evaluation evaluated by the blood rouleaux evaluation unit.6. The blood condition analyzing device according to claim 2 , further comprising:an erythrocyte quantitative evaluation unit configured to evaluate a hematocrit value and/or a hemoglobin amount on the basis of an electrical characteristic of a blood sample at a frequency of 2 to 25 MHz.7. The blood ...

Подробнее
Номер записи: 67
21-01-2016 дата публикации

METHODS AND SYSTEMS FOR TUBE INSPECTION AND LIQUID LEVEL DETECTION

Номер: US20160018427A1
Автор: Ayala Melvin, Lu Jiuliu, Qian Bian, STREIBL Sebastian
Принадлежит:

Container identification data from a container inspection unit that analyzes a container containing a liquid is combined with liquid level detection raw data from a liquid level detection unit that analyzes the container containing the liquid and a liquid level detection result is generated. The liquid level detection result is cross-checked with additional data from the container inspection unit. The result can be used to plan a route for the container in the laboratory automation system.

Подробнее
Номер записи: 68
18-01-2018 дата публикации

ION GENERATION USING MODIFIED WETTED POROUS MATERIALS

Номер: US20180017535A1
Автор: Cooks Robert Graham, Ouyang Zheng
Принадлежит:

The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate. 190-. (canceled)91. A sample analysis system comprising:a cartridge comprising a porous substrate that tapers to a tip and an electrode connected to the porous substrate; anda mass spectrometer.92. The system according to claim 91 , wherein the cartridge is configured such that the tip of the porous substrate does not extend beyond an end of the cartridge.93. The system according to claim 91 , wherein the cartridge further comprises a bottom portion and a detachable cover claim 91 , and the cartridge is configured such that the bottom portion is configured to hold the porous substrate.94. The system according to claim 93 , wherein the cartridge is configured such that voltage is not supplied to the porous material in the cartridge until the detachable cover is connected to the bottom portion.95. The system according to claim 93 , wherein the cartridge further comprises a solvent port.96. The system according to claim 95 , wherein the solvent port is configured for continuous supply of solvent to the porous substrate.97. The system according to claim 95 , wherein the solvent port is configured for supply of only a discrete amount of solvent to the porous substrate such that porous substrate is discrete from a flow of solvent.98. The system according to claim 91 , wherein the system is configured such that the cartridge is ...

Подробнее
Номер записи: 69
21-01-2016 дата публикации

Treatment selection for lung cancer patients using mass spectrum of blood-based sample

Номер: US20160019342A1
Автор: Röder Heinrich, Röder Joanna
Принадлежит:

A test for predicting whether a non-small-cell lung cancer patient is more likely to benefit from an EGFR-I as compared to chemotherapy uses a computer-implemented classifier operating on a mass spectrum of a blood-based sample obtained from the patient. The classifier makes use of a training set which includes mass spectral data from blood-based samples of other cancer patients who are members of a class of patients predicted to have overall survival benefit on EGFRI-Is, e.g., those patients testing VS Good under the test described in U.S. Pat. No. 7,736,905. This class-labeled group is further subdivided into two subsets, i.e., those patients which exhibited early (class label “early”) and late (class label “late”) progression of disease after administration of the EGFR-I in treatment of cancer.

Подробнее
Номер записи: 70
17-01-2019 дата публикации

BLOOD COAGULATION SYSTEM EXAMINATION MODULE, BLOOD COAGULATION SYSTEM EXAMINATION SYSTEM, BLOOD COAGULATION SYSTEM EXAMINATION METHOD, AND DETERMINATION METHOD OF PARAMETER FOR BLOOD COAGULATION SYSTEM EXAMINATION MODULE

Номер: US20190017995A1
Автор: Hayashi Yoshihito
Принадлежит: SONY CORPORATION

Disclosed are a blood coagulation system examination module, a blood coagulation system examination system, and a blood coagulation system examination method, all of which enable to simply and easily measure thrombin potential with a whole blood sample. 1. A blood coagulation system examination module comprising a thrombin potential examination unit configured to examine thrombin potential on a basis of an electrical property of blood as measured at a specific frequency and predetermined time intervals in a predetermined period after reversal of an anticoagulation action working on the blood.2. The blood coagulation system examination module according to claim 1 , wherein the thrombin potential examination unit is configured to analyze a correspondence relationship between the electrical property of the blood claim 1 , which has measured at the specific frequency in the predetermined period claim 1 , and the thrombin potential and to examine thrombin potential of target blood from the electrical property of the target blood on a basis of the correspondence relationship.3. The blood coagulation system examination module according to claim 1 , wherein the thrombin potential examination unit is configured to examine the thrombin potential on a basis of a value G/Aobtained by dividing a maximum gradient (G) of a waveform of the electrical property at the specific frequency in the predetermined period with a maximum amplitude (A) of the waveform of the electrical property at the specific frequency in the predetermined period.4. The blood coagulation system examination module according to claim 1 , wherein the blood contains tissue factor added thereto to have a concentration of 0.5 pM or higher but 1 pM or lower.5. The blood coagulation system examination module according to claim 1 , wherein the specific frequency is 1 kHz or higher but 50 MHz or lower.6. A blood coagulation system examination system comprising:a pair of electrodes,an application unit that applies an ...

Подробнее
Номер записи: 71
17-01-2019 дата публикации

Techniques for determining coagulation results

Номер: US20190018030A1
Автор: Rolf Knobel
Принадлежит: Roche Diagnostics Operations Inc

An automated method for determining a coagulation result of a biological sample is presented. The method includes obtaining a time series representing measurement data of a sample. The time series spans a period in which a clotting reaction is supposed to take place. The method includes obtaining a global model function configured to model measurement data of a sample in which a clotting reaction takes place. The global model function is configured to model the measurement data as a sigmoidal shape with at least one inflection point. The absolute value of the maximum curvature of the sigmoidal shape is larger on one side of the at least one inflection point than on the other side. The method includes fitting the model function to the time series representing measurement data to obtain a fitted model function and determining a coagulation result of the sample based on the fitted model function.

Подробнее
Номер записи: 72
22-01-2015 дата публикации

BLOOD MEASURING APPARATUS

Номер: US20150020613A1
Автор: MASUDA Koji, NIIYAMA Yoshihiro, Suzuki Satoshi
Принадлежит:

A blood measuring apparatus includes: a liquid supply source storing a sheath liquid and applying a pressure to supply the sheath liquid to first and second chambers, pressures of the sheath liquids to be supplied to the first and second chambers different from each other; a sheath flow generator sending a blood sample supplied to the first chamber, to the aperture while causing the blood sample to be converged by a sheath flow due to the sheath liquid supplied from the liquid supply source; and a swirling flow generator causing the blood sample in the second chamber, to be converged by a swirling flow due to the sheath liquid supplied from the liquid supply source, thereby allowing the blood sample to flow in a direction separating from the aperture. 1. A blood measuring apparatus comprising:first and second chambers which communicate with each other through an aperture;first and second electrodes which are provided with the first and second chambers, respectively;a liquid supply source which is configured to store a sheath liquid, and which is configured to apply a pressure to supply the sheath liquid to the first and second chambers, a pressure of the sheath liquid to be supplied to the first chamber different from a pressure of the sheath liquid to be supplied to the second chamber;a sheath flow generator which is configured to send a blood sample supplied to the first chamber, to the aperture while causing the blood sample to be converged by a sheath flow due to the sheath liquid supplied from the liquid supply source; anda swirling flow generator which is configured to cause the blood sample in the second chamber, to be converged by a swirling flow due to the sheath liquid supplied from the liquid supply source, thereby allowing the blood sample to flow in a direction separating from the aperture.2. The blood measuring apparatus according to claim 1 , wherein a single liquid supply source which is configured to supply the sheath liquid to the first and second ...

Подробнее
Номер записи: 73
16-01-2020 дата публикации

Urine flow cytometry as biomarker of renal diseases

Номер: US20200018748A1
Автор: Hannah Antonia BRAND, Nina GÖRLICH, Petra Reinke, Philipp Enghard, Valerie LANGHANS
Принадлежит: Charite Universitaetsmedizin Berlin

The invention provides a method of assigning to a patient a likelihood of having a kidney disease, or a likelihood of undergoing kidney transplant rejection, comprising the steps of providing a urine sample from the patient and determining the concentration of T cells, podocytes and proximal tubular epithelial cells. The ratios of these cell types are used for determining the risk of a kidney disease or transplant rejection.

Подробнее
Номер записи: 74
21-01-2021 дата публикации

SPECIMEN PROCESSING SYSTEM

Номер: US20210018524A1
Автор: BABA Shunsuke, Onizawa Kuniaki
Принадлежит:

A specimen processing system which performs preprocessing and analysis of a specimen includes sensors , . . . each detecting a driving state of a driving device installed in the system, an abnormality detecting part determining from signal waveforms detected by the sensors , . . . whether an abnormality occurs in the driving device, and a recording device sequentially recording the signal waveforms detected by the sensors , . . . and storing a sensor signal waveform before or after the occurrence of an operation abnormality into an unerasable area when the abnormality is determined to have occurred in the abnormality detection part . Consequently, there is provided a specimen processing system capable of realizing restoration from the time of the occurrence of an abnormality faster than in the past. 1. A specimen processing system which performs preprocessing and analysis of a specimen , comprising:sensors each detecting a driving state of a driving device installed in the system; andan abnormality detecting part determining from signal waveforms detected by the sensors whether an abnormality occurs in the driving device,wherein the specimen processing system includes a recording device which sequentially records the signal waveforms detected by the sensors, and stores a sensor signal waveform before or after the occurrence of an operation abnormality into an unerasable area when the abnormality is determined to have occurred in the abnormality detecting part.2. The specimen processing system according to claim 1 ,wherein the sensor includes an imaging device which images a prescribed location in the specimen processing system, andwherein the recording device sequentially records images captured by the imaging device, and stores an image before or after the occurrence of an operation abnormality into an unerasable area when the abnormality is determined to have occurred in the abnormality detecting part.3. The specimen processing system according to claim 1 ,wherein ...

Подробнее
Номер записи: 75
22-01-2015 дата публикации

BLOOD CELL COUNTING DEVICE AND METHOD

Номер: US20150024426A1
Автор: Cabeça Ricardo, De Oliveira Garcia Da Fonseca Joao Manuel
Принадлежит:

A device for use in imaging a liquid sample comprises an inlet for accepting the sample, a connection conduit and a detection chamber for detection of the sample, preferably optical detection of the sample. The connection conduit connects the inlet to the detection chamber and contains one or more dry reagents for reaction with the sample as the sample passes through the connection conduit. Specific embodiments include devices arranged for treating a blood sample, in particular lysing and staining the sample. The liquid flow may be driven by capillary effect. The device may further include liquid handling structures arranged for centrifugally driven liquid flow, for example to meter a volume of sample and separate the sample into phases by centrifugation. 1. A device for use in imaging a liquid sample , the device comprising:an inlet for accepting a sample into the device;a connection conduit;a detection chamber for optical detection of the sample,wherein the connection conduit connects the inlet to the detection chamber, andwherein the connection conduit contains one or more dry reagents for reaction with the sample as the sample passes through the connection conduit.2. The device of claim 1 , wherein the sample is a blood sample claim 1 , the one or more dry reagents include a haemolysing agent for selective lysis of erythrocytes in the blood sample and a staining agent for selectively staining leukocytes in the blood sample.3. The device of or claim 1 , wherein the connection conduit comprises a main conduit portion and one or more protrusions extending from the main conduit portion wherein the dry reagents are stored in the one or more protrusions and respective junction regions between the one or more protrusions and the main conduit portion provide a reaction region in which gradual resuspension of the dry reagents can occur.4. The device of claim 3 , wherein the protrusions comprise a main portion and a neck portion in the region of the junction claim 3 , the ...

Подробнее
Номер записи: 76
26-01-2017 дата публикации

SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE COLLECTION, TRANSPORT, AND HANDLING

Номер: US20170023546A1
Автор: Anekal Samartha, Chen Michael, Holmes Elizabeth A., Lui Clarissa, Young Daniel
Принадлежит:

Bodily fluid sample collection systems, devices, and method are provided. The sample is collected at a first location and subjected to a first sample processing step. The sample may be shipped to a second location and subjected to a second sample processing step that does not introduce contaminants into a plasma portion of the sample formed from the first processing step. 1. A method for use with a bodily fluid sample from a subject , the method comprising:shipping a plurality of sample containers from a first location to a second location, wherein each of said sample containers contains about 500 μL or less but greater than about 30 μL of the bodily fluid sample, wherein interior volume of each of the sample containers is about 600 μL or less,subjecting the bodily fluid sample to a first accelerated sedimentation force of at least about 1400 g or greater to form a first processed sample;shipping the first processed sample from a first location to a second location; andsubjecting the first processed sample at the second location to a second accelerated sedimentation force of greater than about 10 g but less than about 500 g.2. (canceled)3. The method of wherein the first processed sample contains a heparin-based anti-coagulant.4. The method of wherein the first processed sample contains a plasma portion separated by a separation gel from a formed-blood component portion.5. The method of wherein the second processed sample does not force electrolytes though the separation gel from the formed-blood component portion to the plasma portion.6. The method of wherein the second processed sample does not force liquid though the separation gel from the formed-blood component portion to the plasma portion.7. The method of wherein the first accelerated sedimentation force is provided through centrifugation.8. The method of wherein the second accelerated sedimentation force is provided through centrifugation.9. The method of wherein a plurality of samples are shipped from a ...

Подробнее
Номер записи: 77
26-01-2017 дата публикации

BLOOD CONDITION ANALYSIS DEVICE, BLOOD CONDITION ANALYSIS SYSTEM, BLOOD CONDITION ANALYSIS METHOD, AND BLOOD CONDITION ANALYSIS PROGRAM FOR CAUSING COMPUTER TO IMPLEMENT THE METHOD

Номер: US20170023597A1
Автор: BRUN MARCAURELE, Hayashi Yoshihito, MACHIDA KENZO
Принадлежит: SONY CORPORATION

To provide a technology that allows for simple and highly accurate evaluation of the condition of blood. 1. A blood condition analysis device , for analyzing the condition of a blood sample having added thereto at least one kind of drug selected from the group consisting of anticoagulation treatment canceling agents , coagulation activators , anticoagulants , platelet activators , and antiplatelet agents ,the device comprising a drug dosage control unit for controlling the dosage of the drug to be added to the blood sample on the basis of the hematocrit and/or hemoglobin content of the blood sample.2. The blood condition analysis device according to claim 1 , wherein the drug dosage control unit includes a drug dosage determination unit for determining the dosage of the drug to be added to the blood sample on the basis of the hematocrit and/or hemoglobin content of the blood sample.3. The blood condition analysis device according to claim 1 , wherein the drug dosage control unit includes a drug dilution unit for diluting the drug.4. The blood condition analysis device according to claim 2 , further comprising a drug dilution unit for diluting the drug on the basis of the dosage determined by the drug dosage determination unit.5. The blood condition analysis device according to claim 1 , further comprising a drug concentration detection unit for detecting the concentration of the drug to be added to the blood sample.6. The blood condition analysis device according to claim 1 , further comprising an erythrocyte quantitative evaluation unit for determining the hematocrit and/or hemoglobin content on the basis of an electrical characteristic of the blood sample.7. The blood condition analysis device according to claim 1 , further comprising a blood coagulation evaluation unit for evaluating the degree of blood coagulation on the basis of an electrical characteristic of the blood sample.8. The blood condition analysis device according to claim 1 , further comprising a ...

Подробнее
Номер записи: 78
10-02-2022 дата публикации

CAPTURE, IDENTIFICATION AND USE OF A NEW BIOMARKER OF SOLID TUMORS IN BODY FLUIDS

Номер: US20220042970A1
Автор: ADAMS Daniel, Tang Cha-Mei
Принадлежит: Creatv MicroTech, Inc.

A new sensitive cell biomarker of solid tumors is identified in blood. This biomarker can be used to determine presence of solid tumors, rapid determination of treatment response, early detection of cancer, early detection of cancer recurrence, and may be used to determine therapy. 1. A method of screening a subject for cancer , comprising detecting circulating Cancer Associated Macrophage-Like cells (CAMLs) in blood of a subject , wherein said detecting comprises:(a) isolating intact cells of between 20 and 300 micron in size from a biological sample obtained from a subject using a means selected from the group consisting of size exclusion methodology, immunocapture, red blood cell lysis, white blood cell depletion, FICOLL separation, electrophoresis, dielectrophoresis, flow cytometry, magnetic levitation, microfluidic chip, and a combination thereof, and (i) a large atypical polyploid nucleus of about 14-64 μm in size or multiple nuclei, and', '(ii) a morphological shape selected from the group consisting of spindle, tadpole, round, oblong, two legs, more than two legs, thin legs, and amorphous,, '(b) selecting cells isolated in (a) having'}thereby detecting CAMLs in a biological sample from a subject,wherein when CAMLs are detected in the biological sample, the subject is determined to have cancer.2. The method of claim 1 , wherein the cancer is carcinoma or solid tumor.3. The method of claim 1 , wherein the cancer is breast claim 1 , prostate claim 1 , lung claim 1 , pancreatic claim 1 , or colorectal.4. The method of claim 1 , further comprising detecting circulating tumor cells (CTCs) in the biological sample.5. The method of claim 1 , wherein the cells are isolated in (a) using size exclusion methodology.6. The method of claim 5 , wherein the size exclusion methodology is use of a microfilter having pores ranging in size from 5 to 20 microns.7. The method of claim 1 , wherein the blood is peripheral blood.8. A method for confirming a diagnosis of cancer in a ...

Подробнее
Номер записи: 79
24-01-2019 дата публикации

TESTING INSTRUMENT WITH QUALITY CONTROL DETERMINATION AND A METHOD THEREOF

Номер: US20190025279A1
Автор: HSIEH MING-CHEN
Принадлежит:

This disclosure is related to a testing instrument with quality control determination and a method thereof. The testing instrument includes a housing, a monitor, a scanning key, a scanning area, a strip slot and a control circuit. The test instrument has a nursing staff ID table, a strip corresponding table and a quality control testing performance table which are all embedded in the control circuit. The three tables correspond with a step of determining whether the operator matches one of the members listed on the nursing staff ID table, and a step of performing the quality control testing to achieve the automatic determination of whether or not a quality control test has been performed and whether or not the quality control test is passed. 1. A testing instrument with quality control determination , working with a strip bottle and at least one quality control liquid for executing a quality control test , comprising:a housing;a monitor disposed on the top surface of the housing;a scanning button disposed below the monitor;a scanning area disposed on the lower side of the housing, used for scanning a barcode; anda strip slot disposed on one side of the housing;wherein a control circuit is disposed in the housing, coupled to the monitor, the scanning button, the scanning area and the strip slot, and used for controlling the operation of the testing instrument, comparing various quality control tests, and determining whether the quality control test is passed;wherein the control circuit stores a nursing staff ID table, a strip corresponding table and a quality control testing performance table as the basis for the comparison of various quality control tests.2. The testing instrument with quality control determination according to claim 1 , wherein the testing instrument further comprises an enter button and a return button disposed on the top surface of the housing such that a user can conveniently operate the testing instrument;wherein a switch is disposed on one ...

Подробнее
Номер записи: 80
24-01-2019 дата публикации

METHOD OF PREDICTING PATIENT PROGNOSIS USING RARE CELLS

Номер: US20190025282A1
Автор: AKIYAMA Yasuyuki, Futami Toru, Koizumi Fumiaki, Morimoto Atsushi, Sawada Takeshi
Принадлежит:

The purpose of the present invention is to provide a method for accurately predicting a cancer patient prognosis based on a count of desired cells for which expression of a leukocyte marker and an epithelial marker is hardly exhibited by detecting those cells. Provided is a method for diagnosing an overall survival prognosis for a patient suffering from cancer, the method including: a step of obtaining a concentrated solution containing desired cells by pre-treating a biological sample obtained from the patient; a step of optically detecting the concentrated cells; and a step of detecting the desired cells from the detected image, wherein an association is made with the overall survival prognosis diagnosis by counting the detected desired cells, and wherein the desired cells are cells confirmed by the existence of a cell nucleus and in which expression of a leukocyte marker and an epithelial marker is hardly exhibited. 1. A method of determining overall survival prognosis for a patient suffering from cancer , comprising steps of:1) obtaining a concentrated liquid by concentrating target cells from an organism sample obtained from the patient;2) optically detecting and counting cells contained in the concentrated liquid, the cells each having cell nucleus and not substantially expressing a leukocyte marker and an epithelial marker; and3) associating the number of counted target cells and overall survival prognosis.2. The method according to claim 1 , wherein the leukocyte marker is CD45 claim 1 , and the epithelial marker is CK.3. The method according to claim 1 , wherein the target cells have diameters of not less than 10 μm.4. The method according to claim 1 , wherein the target cells are circulating tumor cells (CTCs).5. The method according to claim 1 , wherein the step of obtaining a concentrated liquid is a concentration method based on a specific gravity difference of a biological sample.6. The method according to claim 1 , wherein the pretreatment includes ...

Подробнее
Номер записи: 81
24-01-2019 дата публикации

ENZYME-LINKED IMMUNOASSAY TO DETECT FELIS CATUS GAMMAHERPESVIRUS 1

Номер: US20190025306A1
Автор: Stutzman-Rodriguez Kathryn R., Troyer Ryan M., VandeWoude Susan
Принадлежит: Colorado State University Research Foundation, Inc .

Indirect ELISAs to detect exposure to gammaherpesvirus 1 (FcaGHV1) in domestic cats. These ELISAs detect feline serum antibodies to ORF52 and ORF38 of FcaGHV1. The ELISA assays are sensitive, specific, and adaptable for scale up use in high throughput diagnostics. 1Felis catus. A method of detecting antibodies to gammaherpesvirus 1 (FcaGHV1) in a test sample comprising the steps of:obtaining a test sample;contacting the test sample with recombinant FcaGHV1 ORF38 and ORF52 polypeptides or fragments thereof; anddetecting binding between antibodies to FcaGHV1 in the test sample and at least one of the recombinant FcaGHV1 polypeptides or fragments thereof, whereby the presence of binding between antibodies to FcaGHV1 in the sample and one of the recombinant FcaGHV1 polypeptides or fragments thereof is indicative of antibodies to FcaGHV1 in the test sample.2. The method of detecting antibodies to FcaGHV1 in a test sample according to wherein the test sample is a test sample from a feline.3. The method according to wherein the test sample is a test sample from a domestic cat.4. The method according to wherein the test sample is a blood claim 1 , serum or plasma sample from a domestic cat.5. The method according to wherein the detection assay is an IFA claim 1 , a western blot assay or an ELISA.6. The method according to wherein the detection assay is an indirect ELISA.7. The method of detecting antibodies to FcaGHV1 in a test sample according to further comprising the step of performing qPCR on the sample to screen for FcaGHV1 nucleic acid claim 1 , whereby the presence of FcaGHV1 nucleic acid in the test sample is indicative of an active infection with FcaGHV1 in the animal from which the test sample was obtained.8. The method of detecting antibodies to FcaGHV1 in a test sample according to further comprising:contacting the test sample with additional recombinant FcaGHV1 polypeptides or fragments thereof;detecting binding between antibodies to FcaGHV1 in the test sample ...

Подробнее
Номер записи: 82
29-01-2015 дата публикации

SENSOR STRIP CARTRIDGE, AND BIOMETRIC INFORMATION MEASURING METHOD AND APPARATUS USING THE SAME

Номер: US20150028097A1
Автор: BAEK In-Geol, CHO Chul-Ho, CHO Seong-je, LEE Min-Hyoung
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

A sensor strip cartridge and a biometric information measuring method and apparatus using the same are provided. The biometric information measuring apparatus includes a cartridge accommodator configured to accommodate a sensor strip cartridge including at least one sensor strip, a cartridge information reader configured to read cartridge information about the sensor strip cartridge from the sensor strip cartridge, a controller configured to receive biometric information through the sensor strip, and correct the received biometric information by using a biometric information correction reference corresponding to the cartridge information, and an outputter configured to output the corrected biometric information. 1. A biometric information measuring apparatus comprising:a cartridge accommodator configured to accommodate a sensor strip cartridge comprising at least one sensor strip;a cartridge information reader configured to read cartridge information about the sensor strip cartridge from the sensor strip cartridge;a controller configured to receive biometric information through the sensor strip, and correct the received biometric information by using a biometric information correction reference corresponding to the cartridge information; andan outputter configured to output the corrected biometric information.2. The biometric information measuring apparatus of claim 1 , wherein the cartridge information reader comprises a short-distance communication device configured to receive the cartridge information stored in the sensor strip cartridge from the sensor strip cartridge.3. The biometric information measuring apparatus of claim 1 , wherein the cartridge information reader comprises at least one of a barcode reader device and a quick response (QR) code reader device claim 1 , andthe cartridge information reader is configured to read the cartridge information, which is converted into a barcode or a QR code and stored in the sensor strip cartridge, from the sensor ...

Подробнее
Номер записи: 83
29-01-2015 дата публикации

FLUID TESTING APPARATUS AND METHODS OF USE

Номер: US20150029037A1
Автор: Cohen Eyal, Fuerst Oren, Oppenheim Dov, Plevinski Meir, WEINTRAUB David
Принадлежит:

The invention is directed to a mobile hand held miniature laboratory system in general, and to fluid testing apparatus for performing a parameter measurement in a fluid sample and methods of use in particular. The apparatus comprising: a strip adapted to absorb a fluid sample and to produce a signal indicative of said parameter level in said sample; and adaptor adapted to connect said strip to a smart phone to allow delivery of the produced signal or a correlated signal to said smart phone for obtaining a measurement of said fluid parameter displayed on said smart phone, wherein said testing apparatus relies on said smart phone at least for power supply and display means. The fluid may be a physiological fluid such as blood, urine, saliva or amniotic fluid, or a non-physiological fluid such as fluid obtained from industrial pools for fish or algae growth, or entertainment swimming pools. 1. An apparatus comprising: [ 'wherein the audio jack phone port has at least three audio pins;', 'a connecting plug configured to mate with an audio jack phone port,'}, wherein the first ring is positioned on the connecting plug, and', 'wherein the first ring is configured to mate with a first audio pin of the audio jack phone port;, 'a first ring,'}, wherein the second ring is positioned on the connecting plug, and', 'wherein the second ring is configured to mate with a second audio pin of the audio jack phone port; and, 'a second ring,'}, wherein the third ring is positioned on the connecting plug, and', 'wherein the third ring is configured to mate with a third audio pin of the audio jack phone port;, 'a third ring,'}], 'a glucose monitoring apparatus comprisingwherein at least one of the first, second, and third rings of the connection plug is configured to receive power for the glucose monitoring apparatus from the audio jack phone port;wherein at least one of the first, second, and third rings of the connection plug is configured to receive data from the audio jack phone port ...

Подробнее
Номер записи: 84
10-02-2022 дата публикации

PREPROCESSING AND CONVOLUTIONAL OPERATION APPARATUS FOR CLINICAL DECISION-MAKING ARTIFICIAL INTELLIGENCE DEVELOPMENT USING HYPERCUBIC SHAPES BASED ON BIO DATA

Номер: US20220044765A1
Автор: LEE Ju Beam, SONG Jae Woo
Принадлежит:

The present exemplary embodiments provide a data processing device and method which apply a neural network model to hypercubic data by converting a plurality of dimensions of initial data into a table type data structure and calculating between data matching the table and a designed filter. 1. A data processing method , comprising:preprocessing initial data with table based conversion data; andapplying a filter of a neural network model to the table based conversion data.2. The data processing method according to claim 1 , wherein the preprocessing step includes:converting a first data structure formed by N-dimensional data by N axes (N is a natural number of 2 or larger) into a second data structure formed as a table format.3. The data processing method according to claim 2 , wherein the first data structure includes a hypercube having depth information of four dimension or higher including two dimension and three dimension.4. The data processing method according to claim 2 , wherein in the second data structure claim 2 , (i) coordinate information corresponding to N axes and (ii) value information matching the coordinate information are disposed with reference to a row direction or a column direction.5. The data processing method according to claim 2 , wherein the first data structure includes bio-extraction data indicating a measurement result of flow cytometry of a clinical sample of blood or a biological analysis sample and an analysis technique using flow cytometry and bio extraction data may be expressed by a predetermined standardized format or a flow cytometry standard (FCS) format claim 2 , and the second data structure merges measurement values of some parameters of the bio extraction data and transforms the measurement values into data including a coordinate value for a channel and includes the transformed data and a count value.6. The data processing method according to claim 2 , wherein the preprocessing step includes:designing a filter frame structure ...

Подробнее
Номер записи: 85
28-01-2021 дата публикации

Apparatus, system, and method for collecting a target material

Номер: US20210025794A9
Автор: Daniel CAMPTON, Jonathan Lundt, Joshua Nordberg, Lance U'REN, Ronald Seubert, Steve QUARRE
Принадлежит: Rarecyte Inc

This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a plurality of processing vessels and a collector. The collector funnels portions of the target material from the suspension through a cannula and into the processing vessels. Sequential density fractionation is the division of a sample into fractions or of a fraction of a sample into sub-fractions by a step-wise or sequential process, such that each step or sequence results in the collection or separation of a different fraction or sub-fraction from the preceding and successive steps or sequences. In other words, sequential density fractionation provides individual sub-populations of a population or individual sub-sub-populations of a sub-population of a population through a series of steps.

Подробнее
Номер записи: 86
31-01-2019 дата публикации

Dielectric sensing for sample characterization

Номер: US20190029555A1
Автор: Debnath Maji, Evi Stavrou, Michael Mohseni, Michael Suster, Umut Gurkan
Принадлежит: CASE WESTERN RESERVE UNIVERSITY, US Department of Veterans Affairs VA

As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine at least one permittivity parameter based on the computed dielectric permittivity values over at least a portion of the time interval.

Подробнее
Номер записи: 87
31-01-2019 дата публикации

BLOOD AND BIOLOGICAL SAMPLE COLLECTION DEVICE AND METHOD

Номер: US20190029581A1
Автор: Mink Ronald William, Piacentini Stephen Carl, Smith Paul Robert
Принадлежит: Sedia Biosciences Corporation

Specially designed collection strips and their processing. By using specially designed collection strips, having a backer and one or more absorbent pads, in conjunction with a unique processing method, the processes of analyzing biological samples such as blood, or the like, may be done efficiency with the elimination of cross contamination risk. Identification of the sample stays with the sample throughout the process as it resides on the collection strip. The strip absorbs a known volume. The sample with identification is placed directly in an elution solution, without mechanically separating the sample from its identification information. Elimination of the need for mechanical separation tends to reduce cross contamination, as well as reducing sample processing time. 1. A blood collection device that does not require punching , or folding to obtain a sample for processing comprising:a flat rectangular elongated backer having a first end and a second end;a planar label area disposed on the first end upon which identifying information of a collected sample is recorded; anda separate absorbent pad attached at the second end of the flat rectangular elongate backer that does not require punching to obtain a sample whereby a blood sample is applied to the absorbent pad and dried for later testing, the construction of the blood collection device not requiring a folding, a punching out, or detachment of a portion of the blood collection device containing the blood sample, and whereby the identifying information of the collected sample stays affixed to the sample during processing of the sample.2. The blood collection device of claim 1 , in which the absorbent pad is cellulose.3. The blood collection device of claim 1 , in which the absorbent pad is polyester.4. The blood collection device of claim 1 , in which the absorbent pad is glass fiber.5. The blood collection device of claim 1 , in which the absorbent pad is treated with a detergent.6. The blood collection device ...

Подробнее
Номер записи: 88
17-02-2022 дата публикации

Sample handling device

Номер: US20220048027A1
Автор: Ernest M. Bate, Mika Laitinen, Tom HAYDON
Принадлежит: MAGNASENSE TECHNOLOGIES OY

A sample handling device includes a reservoir for holding a fluid medium. A channel system used in connection with the reservoir includes a dilution portion for a sample to be analyzed with a measurement device. The sample is arranged to be transferred from the dilution portion to the measurement device by the fluid medium. A set of capillary channels in the dilution portion is arranged to be filled by capillary action to collect an established quantity of the sample to be diluted by the fluid medium. A pump transfers the fluid medium from the reservoir to the channel system. The pump includes at least one plunger, a seal separating the reservoir and the channel system and a delivery system of potential energy including a compressible element configured to provide repeatable transfer of the fluid medium from the reservoir to the channel system.

Подробнее
Номер записи: 89
02-02-2017 дата публикации

BLOOD CONDITION ANALYSIS DEVICE, BLOOD CONDITION ANALYSIS SYSTEM, BLOOD CONDITION ANALYSIS METHOD, AND PROGRAM

Номер: US20170030891A1
Автор: BRUN MARCAURELE, Hayashi Yoshihito, KAWAGUCHI KAORI, MACHIDA KENZO, UMETSU TOMOYUKI
Принадлежит:

Provided is a blood condition analysis device, a blood condition analysis system, a blood condition analysis method, and a program, according to which the coagulation system or fibrinolysis system of blood can be accurately evaluated from electrical characteristics. In a blood condition analysis device, an analysis unit is provided for evaluating, with respect to two or more blood samples adjusted from one blood specimen and having different drug types or concentrations, the influence of the drug or a factor in the blood on the coagulation system or fibrinolysis system of the blood on the basis of data of time-dependent changes in electrical characteristics measured at a specific frequency or frequency band. 1. A blood condition analysis device , comprising at least an analysis unit for evaluating , with respect to two or more blood samples adjusted from one blood specimen and having different drug types or concentrations , the influence of the drug or a factor in the blood on the coagulation system or fibrinolysis system of the blood utilizing data of time-dependent changes in electrical characteristics measured at a specific frequency or frequency band.2. The blood condition analysis device according to claim 1 , wherein the drug is an activator or suppressor of the coagulation system or fibrinolysis system of the blood.3. The blood condition analysis device according to claim 1 , wherein the analysis unit calculates claim 1 , from data of time-dependent changes in the electrical characteristics of each blood sample claim 1 , at least one kind of value selected from the group consisting of the coagulation time claim 1 , the clot formation time claim 1 , the maximum clot firmness claim 1 , the maximum lysis claim 1 , the coagulation amplitude claim 1 , the coagulation rate claim 1 , the clot firmness after a predetermined period of time from the coagulation time claim 1 , the clot firmness after a predetermined period of time from the maximum firmness claim 1 , and ...

Подробнее
Номер записи: 90
02-02-2017 дата публикации

BLOOD STATE ANALYSIS DEVICE, BLOOD STATE ANALYSIS SYSTEM, BLOOD STATE ANALYSIS METHOD, AND STORAGE DEVICE

Номер: US20170030934A1
Автор: BRUN MARCAURELE, Hayashi Yoshihito, MACHIDA KENZO
Принадлежит: SONY CORPORATION

A blood state analysis device () that analyzes a state of a blood sample, as used for clotting time testing, said blood sample comprising a plasma and at least one reagent, including a correction unit () configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample. For instance, such device () allows to correct blood clotting time results with respect to concentrations of an anti-coagulant drug present in the blood sample. 1. A blood state analysis device that analyzes a state of a blood sample comprising a plasma and at least one reagent , the device comprising:a correction unit configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, wherein the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample.2. The blood state analysis device according to claim 1 , wherein the correction unit is further configured to correct the measured coagulation evaluation result to a corrected coagulation evaluation result that corresponds to a reference concentration of the at least one reagent in plasma that is substantially equal to a measured concentration of the at least one reagent in the plasma of the blood sample.3. The blood state analysis device according to claim 1 , wherein the correlation is predetermined.4. The blood state analysis device according to ...

Подробнее
Номер записи: 91
04-02-2016 дата публикации

Blood glucose measuring device and method, and electronic device including blood glucose measuring module

Номер: US20160033440A1
Автор: Chul-Ho Cho, Jae-Geol Cho, Kwang-Bok Kim, Seong-Je Cho, Sun-Tae Jung
Принадлежит: SAMSUNG ELECTRONICS CO LTD

A method and device for measuring blood glucose are provided. The device includes a strip receiving part having a plurality of pins therein, the pins being arranged in such a manner that at least one of the pins contacts at least one electrode formed in a blood glucose measurement strip when the blood glucose measurement strip is inserted into the strip receiving part; and a controller configured to identify a type of the blood glucose measurement strip inserted into the strip receiving part and to control application of a testing voltage configured in response to the identified type of the blood glucose measurement strip to each pin of the strip receiving part.

Подробнее
Номер записи: 92
04-02-2016 дата публикации

PLATELET AGGREGATION TEST AND DEVICE

Номер: US20160033475A1
Автор: ROTH Andrew, VERIABO Nicholas J.
Принадлежит:

An assembly for testing platelet aggregation including an electrode subassembly that is mounted in a cuvette subassembly for use with relatively small samples containing platelets. 2. The electrode subassembly of claim 1 , wherein the portions of the two wires that are substantially parallel are spaced from one another about 0.18 to about 0.42 mm apart.3. The electrode subassembly of claim 2 , wherein the portions of the two wires that are substantially parallel are from about 1.9 to about 4.5 mm long.4. The electrode subassembly of claim 2 , wherein the electrically conductive lead comprises a coating of a non-conductive material.5. The electrode subassembly of claim 2 , wherein the downwardly extending member has a narrower protruding portion where the upper end of the conductive wire is mounted.6. The electrode subassembly of claim 2 , wherein the lower ends of the two wires comprise an electrically non-conductive spacer element fixing the two wires in parallel to one another.7. The electrode subassembly of claim 1 , wherein the assembly for measuring platelet aggregation comprises a cuvette subassembly.8. The electrode subassembly of claim 7 , wherein the electrode subassembly is adapted to fit into the cuvette subassembly; wherein the top portion of the electrode subassembly is at the top and the other end of the electrode subassembly is within the cuvette subassembly; wherein the electrode subassembly is relatively fixed; and wherein there is a space between the end of the electrode subassembly and an inner bottom portion of the cuvette subassembly.9. The electrode subassembly of claim 2 , wherein the assembly for measuring platelet aggregation comprises a cuvette subassembly.10. The electrode subassembly of claim 9 , wherein the electrode subassembly is adapted to fit into the cuvette subassembly; wherein the top portion of the electrode subassembly is at the top and the other end of the electrode subassembly is within the cuvette subassembly; wherein the ...

Подробнее
Номер записи: 93
01-02-2018 дата публикации

Electrical characteristic measurement apparatus, electrical characteristic measurement system, electrical characteristic measurement method, and program for electrical characteristic measurement for causing computer to implement the method

Номер: US20180031503A1
Автор: Isao Hidaka
Принадлежит: Sony Corp

A technology is provided that enables high accuracy electrical measurement regardless of the performance and/or the like of a measurement device. There is provided an electrical characteristic measurement apparatus, at least including: a measurement unit that measures an electrical characteristic of a biological sample in a plurality of frequencies; and an assignment unit that performs assignment of a number of measurements and/or a measurement amplitude for each frequency. Use of a combination of a frequency for which the SNR is intentionally left low and a frequency for which the SNR is on the contrary improved when an electrical characteristic of a biological sample is measured in multiple frequencies, can provide, as a result, high accuracy electrical measurement optimal for the purpose of measurement.

Подробнее
Номер записи: 94
01-02-2018 дата публикации

METHOD FOR DETERMINING SEVERITY OF HEMOPHILIA, BLOOD SPECIMEN ANALYZER AND COMPUTER READABLE MEDIUM

Номер: US20180031539A1
Автор: ARAI Nobuo, Matsumoto Tomoko, NOGAMI Keiji, SHIMA Midori, TABUCHI Yuka
Принадлежит:

Disclosed is a method for determining the severity of hemophilia, the method including the steps of: coagulating a blood specimen to acquire a coagulation waveform; acquiring an average change rate of a coagulation rate from the coagulation waveform; and determining the severity of hemophilia in the blood specimen based on the average change rate of the coagulation rate. 1. A method for determining severity of hemophilia , the comprising the steps of:coagulating a blood specimen to acquire a coagulation waveform;acquiring an average change rate of a coagulation rate from the coagulation waveform; anddetermining the severity of hemophilia in the blood specimen based on the average change rate of the coagulation rate.2. The method for determining severity of hemophilia according to claim 1 , wherein the average change rate of the coagulation rate is calculated based on a waveform of rate obtained by differentiating the coagulation waveform.3. The method for determining severity of hemophilia according to claim 2 , wherein the average change rate of the coagulation rate is a magnitude of a slope of a straight line connecting two points on the waveform of rate.4. The method for determining severity of hemophilia according to claim 1 , wherein the average change rate of the coagulation rate is calculated using a maximum coagulation rate (|min1|) and a time until the coagulation rate becomes a maximum (time to |min1|).5. The method for determining severity of hemophilia according to claim 4 , wherein the average change rate of the coagulation rate is calculated by further using a time until coagulation acceleration becomes a maximum (time to |min2|).6. The method for determining severity of hemophilia according to claim 5 , wherein the average change rate of the coagulation rate is calculated by Expression 1 below:{'br': None, '(½×|min1|)/(time to |min1|−time to |min2|)\u2003\u2003Expression 1'}7. The method for determining severity of hemophilia according to claim 5 , ...

Подробнее
Номер записи: 95
17-02-2022 дата публикации

Analytical Tool and Analytical System

Номер: US20220050079A1
Автор: Onuma Naotsugu, SHIGEMITSU Takanari
Принадлежит: ARKRAY, INC.

An analytical tool is provided for analysis of a sample by capillary electrophoresis. The analytical tool includes an inlet reservoir into which a sample is introduced, a capillary tube in communication with the inlet reservoir, a filter through which a liquid from the inlet reservoir passes, an enlarged portion undergoing a sudden increase in a cross-sectional area and being in communication with the inlet reservoir and the capillary tube, and a pressure fluctuation reducer for preventing pressure fluctuation at the enlarge portion from affecting a liquid in the capillary tube. 114-. (canceled)15. An analytical tool for analysis of a sample by capillary electrophoresis , the analytical tool comprising:{'claim-text': ['a secondary reservoir having an opening at a bottom of the secondary reservoir;', 'a connection channel connecting the inlet reservoir to the bottom of the secondary reservoir through the opening, wherein the sample is introduced from the inlet reservoir into the secondary reservoir through the connection channel and the opening of the bottom of the secondary reservoir, an area of the bottom being larger than the cross-section area of the connection channel;', 'a flat member which comprises a liquid-permeable porous material and placed on the bottom of the secondary reservoir so as to cover the opening of the secondary reservoir, contacts with the sample reaching to the secondary reservoir, and allows the sample in the connection channel to enter the secondary reservoir; and', 'a capillary tube in communication with the connection channel at a location between the inlet reservoir and the secondary reservoir, wherein a voltage is applied to the capillary tube for causing electrophoresis.'], '#text': 'an inlet reservoir into which a sample is introduced;'}16. The analytical tool according to claim 15 , wherein the flat member covers at least a part of the bottom of the secondary reservoir and allowing gas flow.17. The analytical tool according to claim ...

Подробнее
Номер записи: 96
17-02-2022 дата публикации

ISOLATION OF CELLS OF EPITHELIAL ORIGIN CIRCULATING IN PERIPHERAL BLOOD

Номер: US20220050098A1
Автор: ALCÁZAR NAVARRETE Bernardino, DE MIGUEL PÉREZ Diego, DÍAZ MOCHÓN Juan José, LORENTE ACOSTA José Antonio, ROMERO PALACIOS Pedro José, SERRANO FERNÁNDEZ María José
Принадлежит:

The present invention provides a method for identifying epithelial cells circulating in peripheral blood, which allows individuals who suffer from a disease that presents with epithelial cell destruction to be discriminated from those who do not. The invention also relates to a kit or device for carrying out the methods of the invention. 121.-. (canceled)22. A method for obtaining data useful for the diagnosis , prognosis and classification of an individual having a disease that presents with tissue destruction and release of lung epithelial cells , said method comprising:{'claim-text': 'where said marker comprises an intracytoplasmic marker, a nuclear marker, a surface marker or a combination thereof', '#text': '(a) incubating a peripheral blood sample with a marker for lung epithelial cells,'}(b) identifying the lung epithelial cells by means of immunocytochemical, molecular and/or cytogenetic techniques;(c) quantifying the number of isolated cells; and(d) classifying the individual in a group of individuals who have a risk of suffering from a disease that presents with tissue destruction and release of epithelial cells when the presence of epithelial cells is identified in peripheral blood.23. The method of further comprising prior to step (a) subjecting the sample of peripheral blood of the individual to a density gradient separation.24. The method of further comprising prior to step (a) one or more of the following steps: subjecting the sample of peripheral blood of the individual to a density gradient separation claim 22 , after the density gradient separation claim 22 , collecting an interphase and washing the interphase with saline buffer before incubating the sample with the markers.25. The method of claim 22 , wherein the intracytoplasmic marker comprises a Cytokeratin claim 22 , a Vimentin claim 22 , a SP1 (Surfactant A and B antigen) claim 22 , or a combination thereof;wherein the nuclear marker comprises a transcription factor; andwherein the surface ...

Подробнее
Номер записи: 97
04-02-2021 дата публикации

MICROFLUIDIC DEVICE, SYSTEM AND METHOD

Номер: US20210031196A1
Автор: CRIVELLI Paul, DAVIDSON Justin, DERFUS Austin, DO Tuan, OLSSON Erik Mikael, TOVAR Armando, WANG MATTHEW
Принадлежит:

A combination of components in a capillary flow channel use capillary forces to passively control the movement of liquid samples within a microfluidic device. To detect a target, a liquid sample introduced to a proximal portion of capillary channel of a microfluidic device moves by capillary action along the specific components of capillary channel. 1. A microfluidic device , comprising:a capillary flow channel comprising a proximal opening and a distal opening;a filter pocket comprising a filter and disposed substantially at the proximal opening;a mixing well, disposed distal to the filter pocket;a dry reagent zone containing a reagent, the dry reagent zone disposed distal to the mixing well;a detection zone, disposed distal to the drug reagent zone,wherein the distal opening is tapered to control a flow rate, and wherein the filter pocket, the mixing well, the dry reagent zone and the detection zone are in fluidic communication.2. The microfluidic device of claim 1 , wherein the filter pocket comprises a sample inlet having a recess configured to receive a liquid sample claim 1 , a filter landing claim 1 , and a vent configured to permit air to be displaced upon receiving the liquid sample.3. The microfluidic device of claim 2 , wherein the filter landing includes a raised plateau extending from a distal edge of the filter pocket.4. The microfluidic device of claim 2 , wherein the filter pocket further comprises a catwalk strip disposed for directing a fluid deposited at the sample inlet to the filter landing.5. The microfluidic device of claim 1 , wherein the mixing well is dimensioned to move a filtered liquid sample by capillary action.6. The microfluidic device of claim 1 , wherein the dry reagent zone contains walls with a hydrophobic ink.7. The microfluidic device of claim 1 , further comprising a pinch region disposed distal to the dry reagent zone.8. The microfluidic device of claim 7 , wherein the pinch region is configured with a lobe claim 7 , ...

Подробнее
Номер записи: 98
31-01-2019 дата публикации

STRIP EJECTION APPARATUS FOR BLOOD GLUCOSE METER

Номер: US20190033285A1
Автор: CHA Geunsig, CHAE Kyungchul, CHOI Hyunho, Nam Hakhyun, RYU Goangyel
Принадлежит:

The present invention relates to a strip ejection apparatus for a blood glucose meter, wherein: an ejector block moving to eject a measurement strip is received in the space inside a housing, whereby it is possible to make the apparatus compact, thereby enhancing space efficiency of the blood glucose meter; components can be mounted on a PCB of the blood glucose meter in units of modules as they are, without any additional separate assembly for the components, whereby it is possible to enhance efficiency of a manufacturing process; a guide protrusion coupled with an ejection switch of the blood glucose meter is selectively formed on the upper or lower portion of the ejector block or formed on both the upper and lower portions thereof, whereby it is possible to enhance the degree of freedom in design of the mounting position of the ejection switch; and the strip ejection apparatus can be applied to various types of blood glucose meters so that it is possible to standardize the type of strip ejection apparatus, thereby reducing manufacturing cost, as well as facilitating component management. 1. A strip unloading device for a blood glucose meter , disposed in the blood glucose meter to unload a test strip loaded therein , the strip unloading device comprising:a housing having a storage space therein and having on one side thereof a strip insert into which the test strip is inserted;a plurality of contact pins disposed in the housing to contact upper and lower surfaces of the test strip loaded into the strip insert; andan unloader block disposed in the housing below the contact pins to linearly move towards or away from the strip insert and having a central unloading protrusion to be engaged with the test strip loaded into the strip insert so as to eject the test strip in the process of moving towards the strip insert, wherein the contact pins are disposed on opposite sides of the unloader block in a width direction thereof relative to the unloading protrusion.2. The ...

Подробнее
Номер записи: 99
05-02-2015 дата публикации

Point of Care Cyanide Test Device and Kit

Номер: US20150037900A1
Автор: Joseph Rella
Принадлежит: CORNELL UNIVERSITY

A device, method, and test kit for rapidly detecting cyanide in a sample. The inventive device comprises a container comprising a sample chamber and a sensor chamber separated by a selectively permeable barrier. The sample chamber contains a reagent for releasing cyanide from the sample, and the sensor chamber contains a cyanide detector comprising a conductive polymer which absorbs the released cyanide, generating a change in signal. Signals can be viewed colorimetrically or transmitted to a LCD/LED panel wherein the cyanide measurement readout is displayed.

Подробнее
Номер записи: 100