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10-05-2016 дата публикации

Импульсный генератор нейтронов

Номер: RU0000161783U1
Автор: Александр Владимирович Нестерович, Александр Евгеньевич Шиканов, Антон Алексеевич Исаев, Борис Юрьевич Богданович, Евгений Дмитриевич Вовченко, Константин Иванович Козловский, Николай Игоревич Криворучко
Принадлежит: Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Национальный исследовательский ядерный университет "МИФИ" (НИЯУ МИФИ)

Импульсный генератор нейтронов, содержащий источник импульсного напряжения с формирующей линией, камеру с двухэлектродным разрядником, соединенным с источником импульсного напряжения, анод в виде симметрично охватывающей катод цилиндрической трубы дрейфа длиной Н с оптическим окном и расположенной на его заднем торце нейтронообразующей мишенью, взрывоэмиссионный игольчатый катод, расположенный соосно с трубой дрейфа в области его переднего торца, плазмообразующую мишень, импульсный лазер, блок синхронизации запуска лазера и генератора импульсного напряжения, фокусирующую линзу, расположенную между импульсным лазером и плазмообразующей мишенью, отличающийся тем, что он содержит второе оптическое окно в камере двухэлектродного разрядника и вторую фокусирующую линзу перед ним, частично прозрачное зеркало, расположенное на трассе лазерного луча под углом π/4 напротив окна в камере разрядника, и зеркало, расположенное за ним на трассе лазерного луча под углом π/4 напротив окна в трубе дрейфа, спиральную линию конической формы, расположенную соосно с трубкой дрейфа, с углом полураствора конуса α в сторону анода, лежащим в пределах π/6≤α≤π/4, имеющей вдоль оси спирали длину h, находящуюся в пределахпри этом плазмообразующая мишень расположена внутри спирали на расстоянииот катода и на расстоянииот оси спирали, где ρ - радиус катода. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 161 783 U1 (51) МПК G21G 4/02 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ТИТУЛЬНЫЙ (21)(22) Заявка: ЛИСТ ОПИСАНИЯ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ 2015149128/07, 17.11.2015 (24) Дата начала отсчета срока действия патента: 17.11.2015 (45) Опубликовано: 10.05.2016 Бюл. № 13 (73) Патентообладатель(и): федеральное государственное автономное образовательное учреждение высшего профессионального образования "Национальный исследовательский ядерный университет "МИФИ" (НИЯУ МИФИ) (RU) 1 6 1 7 8 3 R U (57) Формула полезной модели Импульсный генератор нейтронов, содержащий источник импульсного ...

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Номер записи: 1
17-01-2017 дата публикации

Импульсный генератор нейтронов

Номер: RU0000168025U1
Автор: Александр Евгеньевич Шиканов, Антон Алексеевич Исаев, Евгений Дмитриевич Вовченко, Константин Иванович Козловский
Принадлежит: федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский ядерный университет "МИФИ" (НИЯУ МИФИ)

Предполагаемая полезная модель относится к области нейтронной техники, конкретно, к устройствам для генерации нейтронов при взаимодействии ускоренных нуклидов водорода с твердыми мишенями.Сущность полезной модели заключается в том, что в известном импульсном генераторе нейтронов, содержащем источник высокого напряжения, зарядную линию, камеру с катодом, анодом и цилиндрической дрейфовой трубой, высоковольтным и оптическим вводами, лазер с фокусирующим устройством, цилиндрическая дрейфовая труба камеры с катодом и анодом дополнительно содержит нейтронообразующую мишень на ее внутренней поверхности, катод имеет коническую выемку на пересечении с фокальной плоскостью фокусирующего устройства, причем угол α раствора конической выемки лежит в пределах углов 30°<α<60°, при этом фокальная плоскость фокусирующего устройства лазера расположена на сечении конической выемки, параллельном основанию и лежащей на расстоянии l от основания конической выемки, удовлетворяющему условию: 0,3h<l<0,7h, где h высота конической выемки.Техническим результатом предлагаемого устройства является увеличение эффективности генерации нейтронов и повышение выхода нейтронов в импульсе до величин более чем 10нейтр./имп. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 168 025 U1 (51) МПК G21G 4/02 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ФОРМУЛА ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21)(22) Заявка: 2016119690, 20.05.2016 (24) Дата начала отсчета срока действия патента: 20.05.2016 17.01.2017 Приоритет(ы): (22) Дата подачи заявки: 20.05.2016 (45) Опубликовано: 17.01.2017 Бюл. № 2 Адрес для переписки: 115409, Москва, Каширское ш., 31, НИЯУ МИФИ, ОУИС УНИ, Бейгул Г.В. 1 6 8 0 2 5 R U (57) Формула полезной модели Импульсный генератор нейтронов, содержащий источник высокого напряжения, зарядную линию, камеру с катодом, анодом и цилиндрической дрейфовой трубой, высоковольтным и оптическим вводами, лазер с фокусирующим устройством, отличающийся тем, что цилиндрическая ...

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Номер записи: 2
31-05-2012 дата публикации

Liquid anode radiation source

Номер: US20120133265A1
Автор: Robert Kakonyi
Принадлежит: GE Hungary Kft, Szeged South Lowland Cooperative Res Center of Life Sciences and Material Scie, University of

The present disclosure relates to a liquid anode radiation source ( 10 ) having the ability of turning upside down. The liquid anode radiation source ( 10 ) comprises a body ( 12 ) equipped with inlet and outlet having a wall ( 15 ) limiting the anode space ( 17 ), where the outlet connected to the inlet outside the body ( 12 ) will define a continuous flow path closing through the body, the inlet has a wall limiting an internal cross-section changing towards the anode space ( 17 ), wherein the cross-section of the inlet a deflector ( 11 ) is arranged in a position free of contacting the wall, filling out the cross-section partially and movable to the direction perpendicular to the cross-section; the liquid anode material ( 14 ) arranged in the flow path; the circulation unit inserted in the flow path in such a way that it can ensure the unidirectional movement of the anode material in the flow path.

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Номер записи: 3
21-03-2013 дата публикации

TRACKING REPRESENTATIONS OF INDICATOR BODY PARTS

Номер: US20130072745A1
Автор: Berlinger Kajetan, Brumme Stephan
Принадлежит:

The present invention relates to a method for tracking image sections which represent indicator body parts of a body in a process sequence of images, wherein changes in the position of the indicator body parts are used as an indicator for changes in the position of a treatment body part of the body which is to be treated using a treatment beam, said method comprising the following steps: providing advance image data which describe an advance sequence of images representing a result of an advance analysis of the body; providing process image data which describe the process sequence of images, wherein the process sequence of images represents a result of a process analysis of the body which is performed after the advance analysis; determining, on the basis of the advance image data, sub-images which undergo similar changes in position in the advance sequence; extracting, on the basis of the process image data and the determined sub-images, image sections from the images of the process sequence which have an image content which corresponds to the image content of the determined sub-images; and tracking the extracted image sections in the process sequence. 1. A method for tracking image sections which represent indicator body parts of a body in a process sequence of images , wherein changes in the position of the indicator body parts are used as an indicator for changes in the position of a treatment body part of the body which is to be treated using a treatment beam , said method comprising the following steps:providing advance image data which describe an advance sequence of images representing a result of an advance analysis of the body;providing process image data which describe the process sequence of images, wherein the process sequence of images represents a result of a process analysis of the body which is performed after the advance analysis;determining, on the basis of the advance image data, sub-images which undergo similar changes in position in the advance ...

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Номер записи: 4
28-03-2013 дата публикации

Universal mounting system for calibration source for use in pet scanners

Номер: US20130075599A1
Автор: Keith C. Allberg
Принадлежит: RADQUAL LLC

A universal mounting adapter is configured for interchangeably mounting a calibration source to two or more different imaging devices. The two imaging devices have different mounting brackets so they cannot be used with the same conventional calibration source. The present adapter includes mounting mechanisms for both types of bracket, allowing the attached calibration source to be moved from one imaging device to the other, while maintaining the calibration source in a prescribed geometry within the respective imaging device. This can be performed without the need for any tools.

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Номер записи: 5
28-03-2013 дата публикации

ACTIVITY DELIVERY PROGRESS MONITOR

Номер: US20130079581A1
Автор: Agamaite James A., Descalzi Douglas, Griffith Scott R., Marsh Charles
Принадлежит:

A system and method for monitoring progress of a radiopharmaceutical injection procedure includes: measuring and monitoring radiopharmaceutical activity of a radiopharmaceutical remaining in at least a portion of a disposable administration set used with a radiopharmaceutical fluid delivery system; and displaying the radiopharmaceutical activity remaining in at least the portion of the disposable administration set to an operator. 1. A method for monitoring progress of a radiopharmaceutical injection procedure comprising:measuring and monitoring radiopharmaceutical activity of a radiopharmaceutical remaining in a portion of a disposable administration set used with a radiopharmaceutical fluid delivery device, wherein the measuring and monitoring are performed during the radiopharmaceutical injection procedure; anddisplaying the radiopharmaceutical activity remaining in the portion of the disposable administration set, wherein the displaying is performed during the radiopharmaceutical injection procedure.2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. The method of claim 1 , wherein the measuring and monitoring is performed by one of an ionization chamber claim 1 , a CZT crystal detector claim 1 , a Geiger-Müller counter claim 1 , and a scintillating counter.7. The method of claim 1 , wherein displaying the radiopharmaceutical activity comprises:displaying a representation of the radiopharmaceutical activity remaining in the portion of the disposable administration set on a display device of the radiopharmaceutical fluid delivery device.8. (canceled)9. The method of claim 1 , wherein the measured radiopharmaceutical activity of the radiopharmaceutical remaining in the portion of the disposable administration set is the measured activity as a function of at least one of time claim 1 , flow rate claim 1 , and volume.10. (canceled)11. (canceled)12. The method of claim 1 , wherein the disposable administration set comprises:a medical fluid component;a ...

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Номер записи: 6
23-05-2013 дата публикации

NON-PLANAR TREATMENT BEAM CONTROL

Номер: US20130131430A1
Автор: Berlinger Kajetan, Froehlich Stephan, Gum Franz
Принадлежит:

The present invention relates to a data processing method for determining control data for controlling beam positions which beam positions describe positions which a treatment beam has or would have if emitted by a beam source, the treatment beam being for treating a treatment body part of a patient, said method constituted to be performed by a computer and comprising the steps of: • providing treatment data which comprise data on a position of the treatment body part; • providing condition data which describe: constraints on the beam positions and/or constraints on positional changes of the beam positions, wherein said constraints allow for at least a part of the beam positions to lie not in a common plane; • providing an arrangement of the beam positions on the basis of the treatment data which arrangement fulfils the condition data; • determining control data for controlling a change of a relative position of the beam source relative to the treatment body part for changing the beam positions and for controlling an emission of the treatment beam from the beam source, the determined control data being constituted to change the beam positions to follow the provided arrangement of the beam positions and to cause continuous emission of the treatment beam during a continuous change of the beam positions while the beam positions follow at least a part of the arrangement. 1. A data processing method for determining control data for controlling beam positions which beam positions describe positions which a treatment beam has or would have if emitted by a beam source , the treatment beam being for treating a treatment body part of a patient , said method constituted to be performed by a computer and comprising the steps of:providing treatment data which comprise data on a position of the treatment body part;providing condition data which describe:constraints on the beam positions and/or constraints on positional changes of the beam positions, wherein said constraints allow ...

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Номер записи: 7
13-06-2013 дата публикации

METHOD FOR GENERATING NEUTRONS

Номер: US20130148770A1
Автор: Mofakhami Arash, Nassar Tarek
Принадлежит:

The present invention relates, in particular, to a method for generating neutrons comprising at least the series of steps that consists of: a) placing at least one beam of electrons and at least one beam of nuclei selected from among protons, deuterons and tritons into a predefined spin state and/or an interference state; and b) causing said at least one beam of nuclei and said at least one beam of electrons to collide. 1. A method for generating neutrons comprising at least the successive steps consisting in:a) placing at least one beam of electrons and at least one beam of nuclei chosen from protons, deuterons and tritons in a defined spin state and/or in a spatial interference state, the beams of nuclei and of electrons placed in a spatial interference state each comprising at least one constructive interference region and at least one destructive interference region, andb) causing said at least one beam of nuclei and at least one beam of electrons to collide.2. The method as claimed in claim 1 , wherein the beams of nuclei and of electrons each being placed in a defined spin state and in a spatial interference state in the step a).3. The method as claimed in claim 1 , wherein the spins of the electrons and of the nuclei being claim 1 , in the step b) claim 1 , aligned in the same direction.4. The method as claimed in claim 1 , wherein the spins of the electrons claim 1 , respectively of the nuclei claim 1 , and the velocity vectors of the electrons claim 1 , respectively of the nuclei claim 1 , being colinear in the step b).5. The method as claimed in claim 1 , wherein the velocity vectors of the electrons and of the nuclei claim 1 , caused to collide claim 1 , forming claim 1 , in the step b) claim 1 , an oriented angle of between 170 and 190° or the velocity vectors of the electrons and of the nuclei claim 1 , caused to collide claim 1 , forming claim 1 , in the step b) claim 1 , an oriented angle of between −10 and 10°.6. (canceled)7. The method as claimed in ...

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Номер записи: 8
04-07-2013 дата публикации

Neutron Generator and Method of Use

Номер: US20130168542A1
Автор: Juan Navarro-Sorroche
Принадлежит: Halliburton Energy Services Inc

A neutron generator comprises a cylindrical housing having a target rod concentrically located along a central axis of the cylindrical housing. An array of field ionization nanotips is positioned around an inner surface of the housing, where the array of nanotips extends toward the central axis. A method for logging a formation comprises deploying a logging tool having a neutron generator into a borehole. An array of nanotips is located around an inner cylindrical surface of a cylindrical housing in the neutron generator are energized. An ionizable gas proximate the array of nanotips is ionized. The ions are accelerated radially inward to bombard a titanium layer on an outer diameter of a target rod concentrically located along a central axis of the cylindrical housing to generate neutrons.

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Номер записи: 9
04-07-2013 дата публикации

PARTICLE BEAM IRRADIATION SYSTEM AND PARTICLE BEAM THERAPY SYSTEM

Номер: US20130168571A1
Автор: IWATA Takaaki
Принадлежит: Mitsubishi Electric Corporation

The objective is to eliminate the effect of the hysteresis of a scanning electromagnet so that there is obtained a particle beam irradiation system that realizes high-accuracy beam irradiation. There are provided a magnetic-field sensor that measures the magnetic field of a scanning electromagnet and an irradiation control apparatus that controls the scanning electromagnet based on a measurement magnetic field measured by the magnetic-field sensor and target irradiation position coordinates of a charged particle beam. The irradiation control apparatus is provided with an inverse map means that calculates a target magnetic field, based on the target irradiation position coordinates of the charged particle beam; and a compensator that outputs a control input, to the scanning electromagnet, for controlling the magnetic-field error between the target magnetic field and the measurement magnetic field to be the same as or smaller than a predetermined threshold value. 1. A therapeutic method for performing irradiation of an irradiation subject with a charged particle beam , and treating the irradiation subject comprising:a magnetic-field measurement step that a magnetic-field sensor measures a magnetic field of the scanning electromagnet;a target magnetic field calculation step that an inverse map calculator calculates a target magnetic field, based on target irradiation position coordinates of the charged particle beam;a command value outputting step that a controller creates a command value for the excitation current, which is issued to the scanning power source, so as to make the magnetic-field error between the target magnetic field and the measurement magnetic field the same as or smaller than a predetermined threshold value, and that outputs the command value to the scanning power source.2. A method for performing irradiation of an irradiation subject with a charged particle beam comprising:a magnetic-field measurement step that a magnetic-field sensor measures a ...

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Номер записи: 10
04-07-2013 дата публикации

INTEGRATED RADIATION THERAPY SYSTEMS AND METHODS FOR TREATING A TARGET IN A PATIENT

Номер: US20130172657A1
Автор: Dimmer Steven C., Mate Timothy P., Meier Eric, Purdy Lynn M., Wright J. Nelson
Принадлежит: Varian Medical Sytems, Inc.

An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy. 1. An integrated process for treating a target in a patient with an ionizing radiation beam wherein a marker is positioned within the patient relative to the target , the process comprising:acquiring first target data by locating the marker in a reference frame external to the patient using a marker localization modality;obtaining second target data by locating the marker using the marker localization modality while the patient is at a radiation delivery device that produces the ionizing radiation beam;irradiating the patient with the ionizing radiation beam while obtaining the second target data using the marker localization modality;acquiring hardware data related to the radiation delivery device; andevaluating the radiation delivered to the patient using at least one of the first target data, the second target data, and the hardware data.2. The method of claim 1 , further comprising developing at least a portion of a treatment plan based on the first target data.3. The method of claim 1 , further comprising simulating treatment using the first ...

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Номер записи: 11
18-07-2013 дата публикации

Pulsed Neutron Generator Tube Design Which Extends The Lifetime Of A Cathode

Номер: US20130180780A1
Автор: Chirovsky Leo, Perkins Luke, Reijonen Jani, Vilde Loic
Принадлежит: SCHLUMBERGER TECHNOLOGY CORPORATION

A method for operating a pulsed neutron generator including an ionizer with an electron emitting cathode and a grid wherein the cathode and grid are disposed in a sealed chamber. At least one of the following is applicable to the ionizer; a distance between the cathode and the grid, a cathode current and/or a potential on the grid are selected such that the ionizer operates at most about one-half the space charge limited current for a grid current selected to provide a predetermined amount of neutron production. 1. A method for operating a pulsed neutron generator , comprising an ionizer including an electron emitting cathode and a grid , the cathode and grid disposed in a sealed chamber , the method comprising:selecting at least one of a cathode electron emission rate, a distance between the cathode and the grid and a potential applied to the grid such that the ion generator operates at most about one-half a space charge limited current for a grid current selected to provide a predetermined amount of neutron production.2. The method of wherein the electron emitting cathode is a heated cathode.3. The method of wherein the electron emitting cathode is an unheated cathode.4. The method of wherein the distance between the cathode and the grid is less than 0.055 inches.5. The method of wherein the potential is less than 200 volts.6. The method of wherein the cathode surface area is at most 12 mm.7. A method for pulsed neutron well logging claim 1 , comprising:disposing a pulsed neutron well logging instrument having a pulsed neutron generator and at least one radiation detector axially spaced apart therefrom into a wellbore, the pulsed neutron generator having an ionizer including an electron emitting cathode and a grid, the cathode and grid disposed in a sealed chamber wherein at least one of a cathode electron emission rate, a distance between the cathode and the grid and a potential applied to the grid are selected such that the ion generator operates at most about ...

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Номер записи: 12
08-08-2013 дата публикации

ADDING ENRICHMENT MODULES

Номер: US20130202385A1
Автор: Bradtke Christian, Strukamp Heinrich
Принадлежит: URENCO Limited

An apparatus configured to receive material from a first isotope enrichment module and feed the received material into a second isotope enrichment module and a first storage region of a material storage apparatus; and receive material from the second isotope enrichment module and feed the received material into a second storage region of the material storage apparatus. A corresponding method is also described and an apparatus and corresponding method for controlling feed rates of material into the storage apparatus are also described. 1. A connection apparatus configured to:receive a first material from a first isotope enrichment module and feed the received first material into a second isotope enrichment module and a first storage region of a material storage apparatus; andreceive a second material from the second isotope enrichment module and feed the received second material into a second storage region of the material storage apparatus.2. An apparatus according to claim 1 , wherein the first material is a first isotope depleted material claim 1 , the second material is a second isotope depleted material and the material storage apparatus is an isotope depleted material storage apparatus.3. An apparatus according to claim 1 , which is configured to connect a new enrichment module to an existing enrichment module by:receiving the first material from the first isotope enrichment module and feeding the received first material into an added second isotope enrichment module and a first storage region of the material storage apparatus; andreceiving the second material from the added second isotope enrichment module and feeding the received second material into a second storage region of the material storage apparatus.4. An apparatus according to ; and the second isotope enrichment module connected to receive the first material from the apparatus.5. An apparatus according to claim 1 , further comprising the material storage apparatus.6. An apparatus according to claim 5 ...

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Номер записи: 13
15-08-2013 дата публикации

Compact Radiation Generator

Номер: US20130208840A1
Автор: Groves Joel Lee, Guizelin Fabien, Perkins Luke T., Wraight Peter
Принадлежит:

Various embodiments for shortening the overall length of a pulsed neutron generator having a high voltage power supply are disclosed, including but not limited to, providing the plurality of stages of a high voltage power supply wrapped circumferentially or helically about a radiation generator tube. Various techniques for reducing voltage differentials and mitigating the risk of arcing in these embodiments are also disclosed. 1. A device that produces radiation through the reaction of energetic charged particles accelerated in a DC electrostatic field with a target on which the charged particles impinge , comprising: 1. a source generating charged particles; and', '2. a target onto which the charged particles are directed;, 'a. a sealed generator tube comprisingb. a high voltage supply collocated at least partially with the sealed generator tube that is configured to apply a high voltage between the source and the target to accelerate the charged particles to a predetermined energy level before the charged particles impinge on the target.2. The compact device according to claim 1 , wherein the high voltage supply comprises a step-up transformer operatively coupled to a series of multiplying stages claim 1 , each stage comprising a pair of rectifying diodes and a pair of capacitors.3. The compact device according to claim 1 , wherein the high voltage supply is collocated entirely with the sealed generator tube.4. The device of claim 1 , wherein the radiation produced by the device comprises neutron radiation.5. The device of claim 1 , wherein the radiation produced by the device comprises x-rays.6. The device of claim 1 , wherein the radiation produced by the device comprises gamma-rays.7. The device of claim 1 , wherein the length of the device is overall less than or equal to twenty inches (20 in.).8. The device of claim 1 , the high voltage supply further comprising:a plurality of rings disposed circumferentially in annular fashion around the generator tube, each ...

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Номер записи: 14
15-08-2013 дата публикации

High Voltage Supply For Compact Radiation Generator

Номер: US20130208841A1
Автор: Perkins Luke T., Stoller Christian, Wraight Peter
Принадлежит:

Disclosed is a radiation logging tool, comprising a tool housing; a compact generator that produces radiation; a power supply coupled to the compact generator; and control circuitry. Embodiments of the compact generator comprise a generator vacuum tube comprising a source generating charged particles, and a target onto which the charged particles are directed; and a high voltage supply comprising a high voltage multiplier ladder located laterally adjacent to the generator vacuum tube. The high voltage supply applies a high voltage between the source and the target to accelerate the charged particles to a predetermined energy level. The compact generator also includes an electrical coupling between an output of the high voltage supply and the target of the generator vacuum tube to accommodate the collocated positions of the generator vacuum tube and the high voltage power supply. 1. A compact device that generates radiation , comprising: a source generating charged particles, and', 'a target onto which the charged particles are directed;, 'a generator vacuum tube comprisinga high voltage supply comprising a high voltage multiplier ladder located laterally adjacent to the generator vacuum tube, the high voltage supply being configured to apply a high voltage between the source and the target to accelerate the charged particles to a predetermined energy level; andan electrical coupling between an output of the high voltage supply and the target of the generator vacuum tube, wherein the electrical coupling comprises a high voltage turn-around that accommodates the high voltage multiplier ladder being located laterally adjacent to the generator vacuum tube.2. The compact device according to claim 1 , further comprising a means for reducing electrical field stress at the high-voltage turn-around.3. The compact device according to claim 1 , the generated radiation comprising neutron radiation.4. The compact device according to claim 1 , the generated radiation comprising x ...

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Номер записи: 15
19-09-2013 дата публикации

METHOD AND APPARATUS FOR VERIFYING AN IRRADIATION FIELD

Номер: US20130243157A1
Автор: Gließmann Stefan
Принадлежит: SIEMENS AKTIENGESELLSCHAFT

A radiation therapy device includes an irradiation field limiting apparatus. The irradiation field limiting apparatus includes a collimator for adjusting the irradiation field, and a verification apparatus for visually verifying the irradiation field. The verification apparatus is configured such that the irradiation field is optically displayed on a patient that is positioned at a distance from the isocenter of the radiation therapy device. 1. A radiation therapy device comprising: a collimator operable to set an irradiation field; and', 'a verification apparatus operable to visually verify the irradiation field,, 'an irradiation field limiting apparatus comprisingwherein the verification apparatus is configured such that the irradiation field is optically indicated on a patient that is positioned at a distance from an isocenter of the radiation therapy device.2. The radiation therapy device as claimed in claim 1 , wherein the verification apparatus is arranged outside of the irradiation field limiting apparatus.3. The radiation therapy device as claimed in claim 1 , wherein the verification apparatus is arranged so as to be moveable.4. The radiation therapy device as claimed in claim 1 , wherein the verification apparatus comprises a light-emitting system.5. The radiation therapy device as claimed in claim 4 , wherein the light-emitting system is operable to output a laser beam.6. The radiation therapy device as claimed in claim 5 , wherein the light-emitting system is operable to output a cross laser beam.7. The radiation therapy device as claimed in claim 1 , wherein the verification apparatus is operable to indicate the irradiation field as a function of measurement data that characterize an adjustment of the collimator claim 1 , as a function of control data for adjusting the collimator claim 1 , or a combination thereof.8. The radiation therapy device as claimed in claim 4 , wherein the light-emitting system is operable to simulate an imaging system that is ...

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Номер записи: 16
10-10-2013 дата публикации

Device For Producing Radioisotopes

Номер: US20130266105A1
Автор: Cambriani Andrea, Degeyter Michel, GEETS Jean-Michel, Kiselev Maxim, Lambert Bernard
Принадлежит:

The invention relates to a device () for producing radioisotopes by irradiating a target fluid using a particle beam (). This device comprises an irradiation cell () that includes a cavity () for receiving the target fluid. A non-cryogenic cooling device cools the walls of the cavity (). The cavity () has an inclined surface () downwardly delimiting the cavity () so as to evacuate the target fluid, which condenses on contact with the cooled walls, under gravity towards a metal foil () which closes off this cavity (). The inclined surface () intersects the plane formed by the metal foil (), making an acute angle (a) with said plane, so as to form with the metal foil () a wedge-shaped zone () capable of collecting, by gravity, the condensed target fluid. 1. A device configured to produce radioisotopes through the irradiation of a target fluid comprising a radioisotope precursor using a particle beam , the device comprising:an irradiation cell comprising a cavity configured to contain the target fluid and closed by a metal foil;a cooling device configured to cool the walls of the cavity, and configured to keep at least one fraction of the target fluid comprised in the cavity in a liquid state when the target fluid is irradiated; andan inclined surface, defining the bottom of the cavity, so as to evacuate the target fluid, which condenses in contact with the walls of the cavity that are cooled by the cooling device, by gravity toward the metal foil;wherein the cooling device is a non-cryogenic cooling device; andwherein the inclined surface intersects the plane formed by the metal foil forming an acute angle (α) with the plane, so as to form, with the metal foil, a corner-shaped area capable of collecting the target fluid that condenses in contact with the walls of the cavity cooled by the cooling device by gravity, such that the height of the collected target fluid is maximal at the metal foil and decreases moving away from the metal foil.2. The device according to ...

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Номер записи: 17
24-10-2013 дата публикации

Composite type target, neutron generating method in use thereof and neutron generating apparatus in use thereof

Номер: US20130279638A1
Автор: Hiroshi Matsumoto, Hitoshi Kobayashi, Masakazu Yoshioka
Принадлежит: Inter University Research Institute Corp High Energy Accelerator Research Organization

A target is provided herein such that the radioactivation of a member thereof due to protons may be reduced. In order to reduce the radioactivation of the member due to protons, a novel target composed by compositing a beryllium material (or lithium material) and a nonmetal material is used.

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Номер записи: 18
31-10-2013 дата публикации

DETERMINATION OF A BODY PART POSITION DURING RADIATION THERAPY

Номер: US20130287167A1
Автор: Erbel Stephan, Gum Franz
Принадлежит: BRAINLAB AG

The present invention relates to a data processing method for use in the field of radiation therapy and for determining a position of a treatment body part relative to an actual arrangement of at least one position of a treatment beam issued by a treatment device, the position being called monitoring tissue position and the treatment body part being a soft tissue part of an anatomical structure of a patient; the data processing method being constituted to be performed by a computer and comprising the following steps: providing CBCT data describing a three-dimensional CBCT image of the anatomical structure, the three dimensional CBCT image representing the treatment body part and a bony structure in a relative position to each other, called tissue-bone pre-alignment position, at a point in time, called pre-alignment time; providing x-ray data describing information on a position of the bony structure, called monitoring bone position, relative to the actual arrangement at a point in, time during treatment, called monitoring time, the monitoring time being after the pre-alignment time; determining the monitoring tissue position of the treatment body part relative to the actual arrangement based on the tissue-bone pre-alignment position represented by the CBCT image data, based on the information on the monitoring bone position described by the x-ray data, and based on a predefined relationship between a first relative position between the treatment body part and the bony structure at the pre-alignment time and a second relative position between the treatment body part and the bony structure at the monitoring time. 1. Data processing method for use in the field of radiation therapy and for determining a position of a treatment body part relative to an actual arrangement of at least one position of a treatment beam issued by a treatment device , the position being called monitoring tissue position and the treatment body part being a soft tissue part of an anatomical ...

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Номер записи: 19
07-11-2013 дата публикации

Hydrocarbon Based Ion Source

Номер: US20130294556A1
Автор: Schwoebel Paul
Принадлежит: SRI International, Inc.

The invention provides methods and apparatus for extracting ions, and further for producing neutrons from the extracted ions. In an aspect, there is provided a method for extracting ions involving the following step: in a vacuum chamber applying voltages to a spark gap between two electrodes comprising coatings of a hydrocarbon, each voltage sufficient to trigger a spark discharge in the gap sufficient to dissociate the hydrocarbon and extract therefrom hydrogen ions, wherein the hydrocarbon is a nonvolatile liquid sufficiently non-viscous to flow and re-coat holes in the coatings between each spark discharge. 1. A method for extracting ions , the method comprising:in a vacuum chamber applying voltages to a spark gap between two electrodes comprising coatings of a hydrocarbon, each voltage sufficient to trigger a spark discharge in the gap sufficient to dissociate the hydrocarbon and extract therefrom hydrogen ions, wherein the hydrocarbon is a nonvolatile liquid sufficiently non-viscous to flow and re-coat holes in the coatings between each spark discharge.2. The method of claim 1 , wherein the hydrocarbon is deuterated or tritiated claim 1 , and the ions are deuterium or tritium ions.3. The method of claim 1 , wherein the hydrocarbon is deuterated or tritiated and is heteroatom-containing and aromatic claim 1 , and the ions are deuterium or tritium ions.4. The method of claim 1 , wherein the hydrocarbon is deuterated or tritiated and is an oil claim 1 , is polar or has a molecular weight below 1000 g/mol claim 1 ,5. The method of claim 1 , wherein the hydrocarbon is deuterated or tritiated and is selected from: m-Bis(m-phenoxyphenoxy)benzene claim 1 , polyphenyl ether claim 1 , 1 claim 1 ,3 claim 1 ,5-trimethyl-1 claim 1 ,1 claim 1 ,3 claim 1 ,5 claim 1 ,5-pentaphenyltrisiloxane claim 1 , tetramethyl tetraphenyl trisiloxane claim 1 , dioctyl sebacate claim 1 , pentaerythritol tetrahexanoate claim 1 , and bis(2-ethylhexyl)azelate.6. The method of claim 1 , ...

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Номер записи: 20
07-11-2013 дата публикации

Particle Accelerator With A Heat Pipe Supporting Components Of A High Voltage Power Supply

Номер: US20130294557A1
Автор: Luke Perkins
Принадлежит: Schlumberger Technology Corp

A pulsed neutron generator includes neutron tube and a high voltage power supply. High voltage power supply includes a bulkhead and plurality of electronic components electrically connected between the bulkhead and the target of the neutron tube. A heat pipe is provided in thermal contact with the target and has a housing portion with an exterior surface supporting the plurality of electronic components of the high voltage power supply. Heat pipe includes wick and heat transfer fluid disposed within the housing portion. The wick for recirculates the heat transfer fluid within the housing portion in order to transfer heat away from the target preferably to the bulkhead for dissipation the system housing. Both the wick and heat transfer fluid are preferably realized from materials that have low electrical conductivity. The heat pipe can also be part of other-type particle accelerators, such as x-ray sources and gamma-ray sources.

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Номер записи: 21
14-11-2013 дата публикации

ORTHOVOLTAGE RADIOTHERAPY

Номер: US20130301800A1
Автор: Gertner Michael, Hansen Steven D.
Принадлежит:

Radiosurgery systems are described that are configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, and in some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a fiducial marker is used to identify the location of the target tissues. 1. A system , for treating a target tissue of an eye with x-ray radiation , comprising:a radiation source configured to emit x-ray beams at the target tissue of the eye;an alignment system configured to align the x-ray beams with an axis traversing the target tissue and, based on an indication of a location of the target tissue, directs the x-ray beam to be emitted toward the target tissue; anda holder configured to stabilize the eye during emission of the x-ray beams and comprising a fiducial marker configured to provide the indication of the location of the target tissue.2. The system of claim 1 , wherein the alignment system is configured to align the x-ray beam repeatedly during a treatment session.3. The system of claim 1 , further comprising an imaging system configured to determine the axis traversing the target tissue.4. The system of claim 1 , wherein said axis comprises a geometric axis of the eye.5. The system of claim 1 , wherein said axis comprises a visual axis of the eye.6. The system of claim 1 , further comprising a collimator configured to collimate emitted x-rays into the x-ray beams.7. A system claim 1 , for treating a target tissue with x-ray radiation claim 1 , comprising:a radiation source that emits an x-ray beam and comprises an imageable light source that indicates an approximate center of a beam spot of the x-ray beam at the target tissue;an alignment system that aligns the x-ray beam with an axis traversing the target tissue and that positions the ...

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Номер записи: 22
19-12-2013 дата публикации

Method of Producing Isotopes In A Nuclear Reactor With An Irradiation Target Retention System

Номер: US20130336436A1
Автор: ALLEN Melissa, GILMAN Nicholas, HATTON Heather, II William Earl, Russell
Принадлежит:

Example embodiments are directed to methods of producing desired isotopes in commercial nuclear reactors using instrumentation tubes conventionally found in nuclear reactor vessels to expose irradiation targets to neutron flux found in the operating nuclear reactor. Example embodiments include assemblies for retention and producing radioisotopes in nuclear reactors and instrumentation tubes thereof. Example embodiments include one or more retention assemblies that contain one or more irradiation targets and are useable with example delivery systems that permit delivery of irradiation targets. Example embodiments may be sized, shaped, fabricated, and otherwise configured to successfully move through example delivery systems and conventional instrumentation tubes while containing irradiation targets and desired isotopes produced therefrom. 1. A method of producing isotopes in a nuclear reactor with an irradiation target retention system , the method comprising:inserting at least one irradiation target into an irradiation target retention assembly, the irradiation target configured to substantially convert to a desired radioisotope when exposed to a neutron flux in the operating nuclear reactorconnecting the irradiation target retention assembly to a cable of a delivery system;driving the irradiation target retention assembly on the cable into tubing of the delivery system using a drive mechanism, the tubing being connected to an instrumentation tube of the nuclear reactor;inserting the irradiation target retention assembly on the cable into the instrumentation tube using the drive mechanism;irradiating the at least one irradiation target;removing the irradiation target retention assembly on the cable from the nuclear reactor using the drive mechanism; andharvesting the desired radioisotope from the irradiation target retention assembly.2. The method of claim 1 , wherein the inserting the irradiation target retention assembly on the cable into the instrumentation tube ...

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Номер записи: 23
30-01-2014 дата публикации

METHOD AND APPARATUS FOR GENERATING THERMAL NEUTRONS USING AN ELECTRON ACCELERATOR

Номер: US20140029709A1
Автор: Dale Gregory E., Gahl John M.
Принадлежит:

Apparatus for generating thermal neutrons includes an electron accelerator for generating an electron beam and a converter for converting the electron beam into photons. A receiving device is provided for receiving the photons and includes a material which provides a photoneutron target for the photons, for producing high energy neutrons in a photonuclear reaction between the photons and the photoneutron target, and for moderating the high energy neutrons to generate the thermal neutrons. The electron beam has an energy level high enough to produce photons of sufficient energy to exceed the photodissociation threshold of the selected target material, but that is sufficiently low as to enable the material to moderate the high energy neutrons resulting from the photonuclear reaction. 1. Apparatus for generating thermal neutrons , comprising:an electron accelerator for generating an electron beam;means for converting said electron beam into photons; and,means for receiving said photons and including a material which provides a photoneutron target for said photons for producing high energy neutrons in a photonuclear reaction between said photons and said photoneutron target, and for moderating said high energy neutrons to generate the thermal neutrons;wherein said electron beam has an energy level that is sufficiently low as to enable said material to moderate said high energy neutrons resulting from said photonuclear reaction.2. The apparatus as defined in wherein said electron beam has an energy level of less than approximately 30 MeV.3. The apparatus as defined in wherein said electron beam has an energy level from approximately 5 MeV to approximately 15 MeV.4. The apparatus as defined in further including a control device operatively connected to said electron accelerator for controlling at least said energy level of said electron beam.5. The apparatus as defined in wherein said converting means is an x-ray converter which converts said electron beam into photons ...

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Номер записи: 24
27-03-2014 дата публикации

LOW POWER SEALED TUBE NEUTRON GENERATORS

Номер: US20140086376A1
Автор: Perkins Luke
Принадлежит:

A pulsed neutron generator (PNG) includes a sealed tube and a gas reservoir disposed in the sealed tube. The gas reservoir includes dispersed particles of a thermally reversible hydride-adsorptive material therein. The material panicles having adsorbed therein deuterium and/or tritium. A heated cathode disposed in the sealed tube, wherein heat from the cathode transfers indirectly to the gas reservoir. A gas ionizer is disposed in the sealed tube. A target is disposed in the sealed tube. The target including adsorbed deuterium and/or tritium therein. In another aspect, tube is pre-filled with deuterium and/or tritium, the reservoir is omitted, and an ion beam current is controlled by controlling an ionizer grid voltage and/or current. 1. A pulsed neutron generator , comprising:a sealed tube;a gas reservoir disposed in the sealed tube, the gas reservoir comprising dispersed particles of a thermally reversible hydride-adsorptive material therein, the material particles having adsorbed therein deuterium and/or tritium;a heated cathode disposed in the sealed tube, wherein heat from the cathode transfers indirectly to the gas reservoir;a gas ionizer disposed in the sealed tube;a target disposed in the sealed tube, the target including adsorbed deuterium and/or tritium therein.2. The pulsed neutron generator of wherein the dispersed particles comprise titanium.3. The pulsed neutron generator of wherein the dispersed particles comprise at least one of yttrium claim 1 , vanadium and erbium.4. The pulsed neutron generator of wherein the dispersed particles comprise zirconium.5. The pulsed neutron generator of wherein the gas ionizer comprises a cathode and an anode claim 1 , each electrically connected to a corresponding power supply.6. The pulsed neutron generator of wherein the heated cathode is electrically connected to a controllable electric power supply configured to maintain a selected number of electrons to enable ionization of gas in the sealed tube.7. The pulsed ...

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Номер записи: 25
03-04-2014 дата публикации

Controlling Particle Therapy

Номер: US20140094643A1
Автор: "ONeal, Cooley James, Gall Kenneth P., III Charles D.", Molzahn Adam C., Rosenthal Stanley, Sobczynski Thomas C.
Принадлежит: Mevion Medical Systems, Inc.

An example particle therapy system includes the following: a gantry that is rotatable relative to a patient position; a particle accelerator mounted to the gantry, where the particle accelerator is for outputting a particle beam essentially directly to the patient position; and a control system to receive a prescription and to generate machine instructions for configuring one or more operational characteristics of the particle therapy system. At least one of the operational characteristics relates to a rotational angle of the gantry relative to the patient position. 1. A particle therapy system comprising:a gantry that is rotatable relative to a patient position;a particle accelerator mounted to the gantry, the particle accelerator for outputting a particle beam essentially directly to the patient position; anda control system to generate machine instructions for configuring one or more operational characteristics of the particle therapy system, at least one of the operational characteristics relating to, or being affected by, a rotational angle of the gantry relative to the patient position.2. The particle therapy system of claim 1 , wherein the at least one of the operational characteristics comprises an angular position of the gantry.3. The particle therapy system of claim 1 , further comprising a particle source to provide pulses of ionized plasma to a cavity claim 1 , a pulse of the particle source having a pulse width corresponding to a duration of operation of the particle source to produce the pulse; andwherein the at least one of the operational characteristics comprises a multiplier that is based on a rotational position of the gantry and that that is applied to the pulse width.4. The particle therapy system of claim 1 , wherein at least one of the operational characteristics comprises a dosage of particles output by the particle accelerator.5. The particle therapy system of claim 1 , wherein at least one of the operational characteristics comprises a dose ...

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Номер записи: 26
07-01-2021 дата публикации

NEUTRON CAPTURE THERAPY SYSTEM

Номер: US20210001151A1
Автор: Liu Yuan-Hao
Принадлежит:

A neutron capture therapy system includes a neutron beam generating unit, an irradiation room configured to irradiate an irradiated body with a neutron beam, a preparation room configured to implement preparation work required to irradiate the irradiated body with the neutron beam, and an auxiliary positioner disposed in the irradiation room and/or the preparation room. The irradiation room includes a first shielding wall, a collimator is disposed on the first shielding wall for emitting the neutron beam, the neutron beam is emitted from the collimator and defines a neutron beam axis. The auxiliary positioner includes a laser emitter that emits a laser beam to position the irradiated body. Wherein the position of the laser emitter is selectable. Therefore, the irradiated body can be positioned in any case to implement precise irradiation. 1. A neutron capture therapy system , comprising:an irradiation room configured to irradiate an irradiated body with a neutron beam, wherein the irradiation room comprises a first shielding wall and a collimator disposed on the first shielding wall for emitting the neutron beam, and wherein the neutron beam is emitted from the collimator and defines a neutron beam axis,a preparation room configured to implement preparation work required to irradiate the irradiated body with the neutron beam, andan auxiliary positioner disposed in the irradiation room and/or the preparation room, wherein the auxiliary positioner comprises a laser emitter for emitting a laser beam to position the irradiated body, and wherein a position of the laser emitter is selectable.2. The neutron capture therapy system according to claim 1 , wherein the auxiliary positioner comprises a base and a cantilever extending perpendicularly from the base claim 1 , and the laser emitter is disposed on the cantilever.3. The neutron capture therapy system according to claim 2 , wherein the cantilever is provided with a guiderail for guiding the laser emitter to move and a ...

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Номер записи: 27
05-01-2017 дата публикации

METHODS AND APPARATUS FOR THE PLANNING AND DELIVERY OF RADIATION TREATMENTS

Номер: US20170001033A1
Автор: OTTO Karl
Принадлежит:

Systems for delivering radiation dose to a target area within a subject comprise: a radiation source for outputting a radiation beam; a support for supporting the subject; a movement mechanism for moving the radiation source relative to the subject along a trajectory; one or more sensors for monitoring a position of the subject; and a controller configured, in accordance with a radiation delivery plan, to: determine the position from one or more signals received from the one or more sensors; deactivate delivery of the treatment radiation beam upon determining that the position is outside of an acceptable range; and reactivate delivery of the treatment radiation beam upon determining that the position is within the acceptable range, to thereby deliver dose to the subject according to the radiation delivery plan. 1. A system for delivery of radiation dose to a target area within a subject , the system comprising:a treatment radiation source for outputting a treatment radiation beam;a support for supporting the subject;a movement mechanism for moving the treatment radiation source relative to the subject along a trajectory;one or more sensors for monitoring a position of the subject;a controller configured, in accordance with a radiation delivery plan, to:cause the treatment radiation source to deliver the treatment radiation beam to the subject while causing the movement mechanism to effect relative movement between the treatment radiation source and the subject along the trajectory;while causing the movement mechanism to effect relative movement between the treatment radiation source and the subject along the trajectory, cause the treatment radiation source to vary at least one of an intensity of the treatment radiation beam by varying a radiation output rate of the treatment radiation source according to the radiation delivery plan over at least a portion of the trajectory and a shape of the radiation treatment beam over at least a portion of the trajectory; ...

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Номер записи: 28
02-01-2020 дата публикации

PARTICLE THERAPY WITH MAGNETIC RESONANCE IMAGING

Номер: US20200001115A1
Автор: Dempsey James F., Kawrykow Iwan, SHVARTSMAN SHMARYU M.
Принадлежит: ViewRay Technologies, Inc.

Particle radiation therapy and planning utilizing magnetic resonance imaging (MRI) data. Radiation therapy prescription information and patient MRI data can be received and a radiation therapy treatment plan can be determined for use with a particle beam. The treatment plan can utilize the radiation therapy prescription information and the patient MRI data to account for interaction properties of soft tissues in the patient through which the particle beam passes. Patient MRI data may be received from a magnetic resonance imaging system integrated with the particle radiation therapy system. MRI data acquired during treatment may also be utilized to modify or optimize the particle radiation therapy treatment. 1. A radiation therapy system comprising:a particle therapy delivery system for delivery of radiation therapy to a patient via a particle beam;a magnetic resonance imaging system configured to obtain patient magnetic resonance imaging (MRI) data during the radiation therapy;a dosimetry system for monitoring the radiation therapy to the patient; anda magnetic shielding structure surrounding at least a portion of the dosimetry system.2. The radiation therapy system of claim 1 , wherein the magnetic shielding structure comprises a plurality of shells.3. The radiation therapy system of claim 2 , further comprising an annular disk disposed across one end of at least one of the plurality of shells claim 2 , the annular disk including an aperture configured to allow particles of the particle beam to pass through.4. The radiation therapy system of claim 1 , further comprising a controller configured to:receive radiation therapy beam information during the radiation therapy;receive the patient MRI data during the radiation therapy; andutilize the patient MRI data and the radiation therapy beam information to perform real-time calculations of a location of dose deposition for the particle beam, taking into account interaction properties of soft tissues through which the ...

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Номер записи: 29
02-01-2020 дата публикации

MEASUREMENT DEVICE AND MEASUREMENT PROBE

Номер: US20200001116A1
Автор: IMAHORI Yoshio, KATO Shinsuke, Miyazaki Hideki, SAKURAGI Akari, TAKEUCHI Norihide, TAKEYOSHI Tsuyako
Принадлежит:

A measurement device includes a sensing portion and a measuring portion. The sensing portion contains at least a fluorescent material whose emitting of fluorescent light ceases due to an action of a radioactive beam. The measuring portion measures a radiation quantity of the radioactive beam, with which the sensing portion is irradiated, based on an amount of decrease in the intensity of the fluorescent light emitted by the fluorescent material contained in the sensing portion when the radioactive beam acts on at least a portion of the fluorescent material. The fluorescent light is emitted due to irradiation of the fluorescent material by an excitation source. 1. A measurement device , comprising:a sensing portion containing at least a fluorescent material whose emitting of fluorescent light ceases due to an action of a radioactive beam; anda measuring portion measuring a radiation quantity of the radioactive beam, with which the sensing portion is irradiated, based on an amount of decrease in the intensity of the fluorescent light emitted by the fluorescent material contained in the sensing portion when the radioactive beam acts on at least a portion of the fluorescent material, the fluorescent light being emitted due to irradiation of the fluorescent material by an excitation source.2. The measurement device according to claim 1 , whereinthe radioactive beam is a neutron beam, andthe fluorescent material contains at least one of lithium, boron, cadmium, gadolinium, samarium, europium, and dysprosium.3. The measurement device according to claim 1 , whereinthe measuring portion measures the radiation quantity based on a relationship between the intensity of the fluorescent light emitted from the fluorescent material before the sensing portion is irradiated by the radioactive beam and the intensity of the fluorescent light emitted from the fluorescent material after the sensing portion is irradiated by the radioactive beam.4. The measurement device according to claim ...

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Номер записи: 30
03-01-2019 дата публикации

RADIOTHERAPY SYSTEM AND TREATMENT SUPPORT APPARATUS

Номер: US20190001155A1
Автор: OHISHI Satoru
Принадлежит: Canon Medical Systems Corporation

According to one embodiment, the radiotherapy system includes a medical image collecting device, a body surface data collecting device and processing circuitry. The medical image collecting device collects medical three-dimensional image data of the patient at the time of treatment planning. The body surface data collecting device collects body surface data representing a three-dimensional body surface of the patient at the time of treatment planning. The processing circuitry may generate integrated data in which at least one of the medical three-dimensional image data and the treatment target region data included in the medical three-dimensional image data, and the body surface data are integrated into an identical three-dimensional coordinate system. 1. A radiotherapy system comprising:a medical image collecting device that collects medical three-dimensional image data of a patient at a time of treatment planning;a first body surface data collecting device that collects first body surface data representing a three-dimensional body surface of the patient at the time of treatment planning; andprocessing circuitry that generates integrated data in which at least one of the medical three-dimensional image data and treatment target region data included in the medical three-dimensional image data, and the first body surface data are integrated into an identical three-dimensional coordinate system.2. The radiotherapy system according to claim 1 , further comprising:a treatment bed that movably supports a treatment top plate on which the patient is placed; anda radiotherapy gantry that irradiates the patient with radiation,wherein the processing circuitry arranges the integrated data at a treatment position and displays the integrated data arranged at the treatment position on a display device.3. The radiotherapy system according to claim 2 ,wherein the display device is a head mounted display,wherein a position detector provided on the head mounted display is further ...

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Номер записи: 31
03-01-2019 дата публикации

MOVING FLOOR FOR RADIOTHERAPY SYSTEM WITH CANTILEVER GANTRY ASSEMBLY

Номер: US20190001157A1
Автор: HUANG Congyi, NORMAN Alexander, Rogers Mark, Stacey Gary
Принадлежит:

A proton beam therapy system with a cantilever gantry system and a moving floor system. The moving floor system includes a flexible moving floor and a track that is disposed vertically and affixed to an external wall. The track includes a lateral portion providing a linear lateral path for the part of the moving floor and non-lateral portions providing a vertical path for the excess of the floor. The non-lateral portions may be located above or below the lateral portion. During rotation of the cantilever gantry and when the beam nozzle is positioned under the patient table, an opening is maintained in the floor through which the beam nozzle protrudes. The opening follows the changing positions of the beam nozzle and moves in the floor plane in synchronization with the rotation of the gantry. 1. A radiotherapy system comprising:an accelerator configured to provide a particle beam with an initial energy;a support member operable to be coupled to an external supporting structure;a cantilever gantry assembly coupled to said accelerator and said support member and comprising a gantry beamline configured to transport said particle beam, wherein said cantilever gantry assembly is configured to be supported by said support member in a cantilevered manner;a beam nozzle coupled to said cantilever gantry assembly and configured to irradiate said particle beam onto a target object; and support a user;', 'move in a lateral plane in synchronization with rotation of said cantilever gantry assembly and perpendicular to a rotation axis of said cantilever gantry assembly; and', 'during movement in said lateral plane, maintain an opening that allows said beam nozzle to protrude therefrom and toward said target object when said cantilever gantry assembly is located below said lateral plane during rotation., 'a moving floor configured to2. The radiotherapy system of further comprising a track configured to be affixed to an external wall and to support the moving floor claim 1 , wherein ...

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Номер записи: 32
06-01-2022 дата публикации

METHOD FOR TRANSFERRING A RADIOISOTOPE BETWEEN TWO STATIONARY PHASES CONTAINED IN TWO CHROMATOGRAPHY COLUMNS

Номер: US20220003723A1
Автор: Dureau Rémy, Torgue Julien
Принадлежит:

A method for transferring a radioisotope which is fixed on a first stationary phase contained in a first chromatography column to a second stationary phase contained in a second chromatography column, to fix the radioisotope on the second stationary phase, wherein the radioisotope is selected from the radioactive isotopes of thorium, radium, lead, bismuth and uranium, the method comprising at least the following steps: a) eluting the radioisotope from the first stationary phase with an aqueous solution A1 comprising an agent complexing the radioisotope, whereby an aqueous solution A2 which comprises complexes of the radioisotope is obtained; b) dissociating the complexes of the radioisotope present in the aqueous solution A2 by modifying the pH of the aqueous solution A2, whereby an aqueous solution A3 comprising the decomplexed radioisotope is obtained; c) loading the second stationary phase with the aqueous solution A3; and d) washing at least one the second stationary phase with an aqueous solution A4. 1. A method for transferring a radioisotope which is fixed on a first stationary phase contained in a first chromatography column to a second stationary phase contained in a second chromatography column , to fix the radioisotope on the second stationary phase , the radioisotope being a radioactive isotope of thorium , radium , lead , bismuth or uranium , which comprises at least the following steps:a) eluting the radioisotope from the first stationary phase with an aqueous solution A1 comprising an agent complexing the radioisotope, whereby an aqueous solution A2 which comprises complexes of the radioisotope is obtained;b) dissociating the complexes of the radioisotope present in the aqueous solution A2 by modifying a pH of the aqueous solution A2, whereby an aqueous solution A3 comprising the radioisotope in decomplexed form is obtained;c) loading the second stationary phase with the aqueous solution A3; andd) washing at least once the second stationary phase with ...

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Номер записи: 33
05-01-2017 дата публикации

TARGET ASSEMBLY AND ISOTOPE PRODUCTION SYSTEM HAVING A VIBRATING DEVICE

Номер: US20170004897A1
Автор: Eriksson Tomas, Holmgren Bert
Принадлежит:

Target assembly for an isotope production system. The target assembly includes a target body having a production chamber and a beam cavity that is adjacent to the production chamber. The production chamber is configured to hold a target liquid. The beam cavity opens to an exterior of the target body and is configured to receive a particle beam that is incident on the production chamber. The target assembly also includes a vibrating device that is secured to the target body. The vibrating device is configured to cause vibrations that are experienced within the production chamber. 1. A target assembly for an isotope production system , the target assembly comprising:a target body having a production chamber and a beam cavity that is adjacent to the production chamber, the production chamber configured to hold a target liquid, the beam cavity opening to an exterior of the target body and being configured to receive a particle beam that is incident on the production chamber; anda vibrating device secured to the target body, the vibrating device configured to cause vibrations that are experienced within the production chamber,2. The target assembly of claim 1 , wherein the target body includes first and second body sections that are secured to each other and have fixed positions relative to each other claim 1 , the production chamber being defined by at least one of the first body section or the second body section claim 1 , the vibrating device being secured to at least one of the first body section or the second body section.3. The target assembly of claim 1 , wherein the vibrating device is secured to a designated surface of the target body claim 1 , the target body comprising a solid material claim 1 , wherein a continuous path of the solid material exists between the designated face and a surface that defines the production chamber.4. The target assembly of claim 3 , wherein a cooling channel extends through the solid material of the target body and proximate to the ...

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Номер записи: 34
13-01-2022 дата публикации

METHOD FOR PREPARING AT LEAST ONE GENERATOR WITH A HIGH RADIUM-228 CONTENT

Номер: US20220013246A1
Автор: Dureau Rémy, Torgue Julien
Принадлежит:

A method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) that it can be used to prepare are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers. 1. A method for preparing at least one generator comprising radium-228 from an aqueous solution A1 comprising thorium-232 and radium-228 , comprising at least the steps of:a) circulating in a first chromatography column a volume V1 of the aqueous solution A1, the first chromatography column comprising a first stationary phase consisting of a solid material which selectively retains radium with respect to thorium;b) washing at least once the first stationary phase with an aqueous solution A2;c) eluting the radium-228 from the first stationary phase with a volume V3 of an aqueous solution A3 comprising an agent complexing radium-228, the volume V3 being between 0.005% and 1% of the volume V1 of the aqueous solution A1 having circulated in the first chromatography column, whereby an aqueous solution A4 which comprises radium-228 complexes is obtained;d) dissociating the radium-228 complexes present in the aqueous solution A4 by modifying a pH of the aqueous solution A4, whereby an aqueous solution A5 comprising the radium-228 in a decomplexed form is obtained;e) loading a second chromatography column with the aqueous solution A5, the second chromatography column comprising a second stationary phase consisting of a same material as the first stationary phase; andf) washing at least once the second stationary phase with an aqueous solution A6, whereby the at least one generator is obtained.2. The ...

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Номер записи: 35
02-01-2020 дата публикации

APPARATUS AND METHOD FOR NEUTRON TRANSMUTATION DOPING OF SEMICONDUCTOR WAFERS

Номер: US20200005957A1
Автор: Bina Markus, Schulze Hans-Joachim, Schustereder Werner
Принадлежит:

An apparatus for processing a plurality of semiconductor wafers, the apparatus including a spallation chamber, a neutron producing material mounted in the spallation chamber, a neutron moderator, and an irradiation chamber coupled to the spallation chamber, wherein the neutron moderator is disposed between the spallation chamber and the irradiation chamber, wherein the irradiation chamber is configured to accommodate the plurality of semiconductor wafers, wherein each of the plurality of semiconductor wafers has a first surface and a second surface opposite the first surface, wherein the plurality of semiconductor wafers are positioned so that a first surface of one semiconductor wafer faces a second surface of another semiconductor wafer. 1. An apparatus for processing a plurality of semiconductor wafers , the apparatus comprising:a spallation chamber;a neutron producing material mounted in the spallation chamber;a neutron moderator; andan irradiation chamber coupled to the spallation chamber, wherein the neutron moderator is disposed between the spallation chamber and the irradiation chamber, wherein the irradiation chamber is configured to accommodate the plurality of semiconductor wafers, wherein each of the plurality of semiconductor wafers has a first surface and a second surface opposite the first surface, wherein the plurality of semiconductor wafers are positioned so that a first surface of one semiconductor wafer faces a second surface of another semiconductor wafer.2. The apparatus of claim 1 ,wherein the neutron producing material comprises lithium, lithium/carbon mixture, tungsten, boron, or boron compounds.3. The apparatus of claim 1 , further comprising:an adjustable mount, wherein the neutron producing material is mounted on the adjustable mount.4. The apparatus of claim 1 , further comprising:a cooling unit coupled to the neutron producing material.5. The apparatus of claim 1 ,wherein the neutron moderator comprises heavy water, carbon, or carbon ...

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Номер записи: 36
20-01-2022 дата публикации

RADIATION SYSTEMS FOR RADITION TREATMENT AND IMAGING

Номер: US20220016443A1
Автор: JIANG Yifeng, MALTZ Jonathan, NI Cheng, STAHL Johannes, WANG LI, ZHOU Jingjie
Принадлежит: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.

A radiation system is provided. The radiation system may include a bore accommodating an object, a rotary ring, a first radiation source and a second radiation source mounted on the rotary ring and a processor. The first radiation source may be configured to emit a first cone beam toward a first region of the object. The second radiation source may be configured to emit a second beam toward a second region of the object, the second region including at least a part of the first region. The processor may be configured to obtain a treatment plan of the object, the treatment plan including parameters associated with radiation segments. The processor may be further configured to control an emission of the first cone beam and/or the second beam based on the parameters associated with the radiation segments to perform a treatment and a 3-D imaging simultaneously. 1. A radiation system , comprising:a bore configured to accommodate an object;a rotary ring;a first radiation source mounted on the rotary ring and configured to emit a first cone beam toward a first region of the object;a second radiation source mounted on the rotary ring and configured to emit a second beam toward a second region of the object, the second region including at least a part of the first region; and obtain a treatment plan of the object, the treatment plan including one or more radiation segments;', 'cause the rotary ring to rotate around the object in one direction continuously for at least two full rotations; and', 'control an emission of at least one of the first cone beam or the second beam based on the treatment plan to perform a treatment and a 3-D imaging simultaneously., 'a processor configured to cause the radiation system to2. The radiation system of claim 1 , wherein the processor is further configured to cause the radiation system to:obtain respiration information of the object;determine a rotation parameter of the rotary ring based on the respiration information of the object; ...

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Номер записи: 37
11-01-2018 дата публикации

RADIOTHERAPY DEVICE CONTROL APPARATUS AND CONTROL METHOD

Номер: US20180008842A1
Автор: Kaneko Shuji, Takahashi Kunio
Принадлежит: Hitachi, Ltd.

A radiotherapy device control apparatus instructs a radiotherapy device to execute instruction information based on a treatment regimen determined in advance, controls the operations of an irradiation-related instrument provided in the radiotherapy device on the basis of irradiation conditions included in the instruction information, determines whether irradiation is permitted on the basis of results detected by an irradiation target detection unit that detects movement of a target to be irradiated, controls execution and interruption of therapeutic irradiation on the basis of the determined result, stores the history of interruption of irradiation according to the determination by the irradiation permission determination unit, and causes the instrument to run the operations based on the instruction information to completion, regardless of whether irradiation has been interrupted during execution of the instruction information. 1. A radiotherapy device control apparatus comprising:a therapy plan execution unit that instructs execution of instruction information based on a therapy plan which is defined in advance;an irradiation operation controller that controls an operation of a device related to irradiation provided on a radiotherapy device, based on an irradiation condition included in the instruction information;an irradiation possibility judging unit that judges whether or not irradiation is possible based on a detection result of an irradiation target detector that detects a motion of an irradiation target;an irradiation controller that controls execution and interruption of irradiation of a therapeutic radiation based on a result of the judgment; andan irradiation recorder that records an interruption history of irradiation by the judgment of the irradiation possibility judging unit, whereinthe irradiation operation controller executes the operation of the device based on the instruction information to the last operation regardless of presence or absence of an ...

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Номер записи: 38
14-01-2021 дата публикации

MEDICAL DEVICE FOR RADIOTHERAPY TREATMENT

Номер: US20210008390A1
Автор: ESCARGUEL Bruno
Принадлежит:

The invention relies on a medical device for an intracorporeal location, wherein: 1. A medical device for an intracorporeal location , the medical device comprising:a deformable armature, at least partially made of a shape memory material and having at least one Ea end being a longitudinal direction of the medical device and at least one Eb end being a lateral direction of the medical device, said Ea end being larger than said Eb end,a three-dimensional shape, having a triangular or a trapezoidal cross-section in a lateral view or an axial view, with the Eb end forming the top side of said triangular or trapezoidal shape, wherein the Ea end forms the base of said triangular or trapezoidal shape located opposite the Eb end and having sides extending between the Eb end and the corners of the Ea end, wherein a triangular or trapezoidal area spans between the sides, and the base is concavely curved so that the medical device has a concave curvature, at least one x-ray visible marker fixed at the deformable armature selected from the group consisting of gold, silver, platinum, tantalum, tungsten, niobium, palladium, and iridium, and', 'a guide suited for the intracorporeal introduction of said medical device, and an extraction holder of the medical device., 'wherein said deformable armature optionally includes a middle rip extending from said Ea end to said Eb end and multiple cross elements extending between the middle rip and said sides, wherein said sides are formed by 1 to 10 sides braces, the medical device further comprising2. The medical device according to claim 1 , including a deformable material forming a surface of the medical device.3. The medical device according to claim 1 , comprising a predetermined breaking point.4. The medical device according to claim 3 , comprising a means for at least one of fastening or opening providing said predetermined breaking point.5. The medical device according to claim 4 , in which said means for at least one of fastening ...

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Номер записи: 39
14-01-2021 дата публикации

PARTICLE BEAM THERAPY SYSTEM, PARTICLE BEAM THERAPY SYSTEM CONSTRUCTION METHOD, AND PARTICLE BEAM THERAPY APPARATUS

Номер: US20210008393A1
Автор: KANAI Yoshiharu, NAGAMOTO Yoshifumi, Yazawa Takashi
Принадлежит:

According to one embodiment, a particle beam therapy system comprising: a circular accelerator configured to accelerate charged particles; a beam transportation line configured to lead the charged particles accelerated by the circular accelerator to an irradiation room; a shielding wall that is disposed around a radiation controlled area and shields radiation to be generated from the circular accelerator and the beam transportation line, the radiation controlled area being an area where the circular accelerator and the beam transportation line are disposed; a specific portion that is provided at a position that separates the radiation controlled area from outside of the shielding wall and can form an additional opening portion of the irradiation room; and a blocking portion configured to close the specific portion and shield radiation passing through the specific portion. 1. A particle beam therapy system comprising:a circular accelerator configured to accelerate charged particles;a beam transportation line configured to lead the charged particles accelerated by the circular accelerator to an irradiation room;a shielding wall that is disposed around a radiation controlled area and shields radiation to be generated from the circular accelerator and the beam transportation line, the radiation controlled area being an area where the circular accelerator and the beam transportation line are disposed;a specific portion that is provided at a position that separates the radiation controlled area from outside of the shielding wall and can form an additional opening portion of the irradiation room; anda blocking portion configured to close the specific portion and shield radiation passing through the specific portion.2. The particle beam therapy system according to claim 1 , wherein the specific portion is disposed at a position opposite to a region where a center of the circular accelerator is located with respect to a centroid of the radiation controlled area in plan view. ...

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Номер записи: 40
10-01-2019 дата публикации

IRRADIATION TREATMENT PLAN SYSTEM AND METHOD

Номер: US20190009107A1
Автор: MARASH Michael
Принадлежит:

An irradiation treatment planning method constituted of: controlling a patient support member to rotate about a first axis by an initial rotation angle; imaging the patient; receiving treatment prescriptions; and responsive to the patient image, the treatment prescriptions and allowable ranges of rotation about at least two orthogonal axes, determining an irradiation treatment plan, wherein in the event that the irradiation treatment plan does not meet the treatment prescriptions, the method further comprises: responsive to the patient image, the treatment prescriptions and the allowable rotation ranges, determining rotation angles of the patient support member about the first axis; for each rotation angle, controlling the patient support member to rotate about the first axis by the rotation angle and imaging the patient; and for each rotation angle, determining an irradiation treatment plan portion responsive to the patient image, the treatment prescriptions and the allowable rotation ranges. 1. An irradiation treatment plan system comprising:a patient support member arranged to support a patient, said patient support member arranged to be rotated about three orthogonal axes;an imager;a memory, said memory having stored thereon, for at least two of the three orthogonal axes, information regarding an allowable range of rotation of said patient support member about the respective axis; and control said patient support member to rotate about a first of the three orthogonal axes by a predetermined initial rotation angle;', 'subsequent to said rotation about the first axis, control said imager to image the patient;', 'receive information regarding treatment prescriptions of the patient; and', wherein said control circuitry is further arranged, in the event that said determined first irradiation treatment plan meets the patient treatment prescriptions, to output said determined first irradiation treatment plan, and', responsive to said patient image, said received ...

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Номер записи: 41
09-01-2020 дата публикации

RADIATION THERAPY APPARATUS

Номер: US20200009404A1
Автор: FUJII Takaaki, MATSUURA Taeko, Miyamoto Naoki, TAKAO Seishin, UMEGAKI Kikuo
Принадлежит:

Through the present invention, three-dimensional coordinates of a tracking object moving in an irradiation object can be calculated from fluoroscopic X-ray images captured and acquired from various angles in a single fluoroscopic X-ray device mounted to a radiation therapy apparatus. The three-dimensional coordinates of the tracking object are calculated on a straight tracking object presence line connecting an X-ray generating device for fluoroscopy and the position in an X-ray plane detector of the tracking object on the fluoroscopic X-ray image acquired by the X-ray generating device for fluoroscopy and the X-ray plane detector, and using line segment information included in a movement region of the tracking object set in advance (S). 1. A radiation therapy apparatus comprising:a couch that supports an irradiation target;a gantry that is movable around the irradiation target to irradiate the irradiation target on the couch with therapeutic radiation from various angles;a fluoroscopic X-ray generation device and an X-ray flat panel detector that are installed on the gantry and used for acquiring a fluoroscopic X-ray image;a CBCT imaging device that performs cone beam CT imaging by using the fluoroscopic X-ray generation device and the X-ray flat panel detector to acquire a cone beam CT image; anda two-dimensional moving object tracking device that two-dimensionally tracks a tracking target object projected within the irradiation target in the fluoroscopic X-ray image, whereinthree-dimensional coordinates of the tracking target object are obtained as coordinates that are included in a movement area set in advance, the three-dimensional coordinates being on a tracking target object passing straight line formed by connecting to each other three-dimensional coordinates in a therapy room coordinate system for an image of the tracking target object projected on each fluoroscopic X-ray image and three-dimensional coordinates of the X-ray generation device.2. The ...

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Номер записи: 42
09-01-2020 дата публикации

IMAGE-GUIDED RADIATION THERAPY

Номер: US20200009405A1
Автор: BOL Gijsbert Herman, KONTAXIS Charis, RAAYMAKERS Bas Willem
Принадлежит: ELEKTA AB (PUBL)

The disclosed systems and methods for Image-Guided Radiation Therapy (IGRT), utilises an iterative approach which adjusts a treatment plan based on inter- or intra-fraction images to improve the accuracy of the radiation delivered during the overall treatment. The prescribed dose of radiotherapeutic radiation is mapped onto the patient's anatomy using an image acquired of the region, which is to be the target for radiotherapeutic radiation. Following beam-angle-optimisation, fluence optimisation and segmentation, the efficiency of delivery of each segment is determined using an objective function, and the segments ranked according to their efficiency. The plan proceeds with the choice of the most efficient segment (or segments) to be delivered first. When this radiation has been delivered, having been tracked to establish its distribution, this delivered distribution can be subtracted from the original prescribed dose and the process repeated so that the delivered radiation gradually converges on the original prescribed dose. 139-. (canceled)40. A controller for a radiotherapeutic apparatus , the controller configured to perform operations comprising:receiving an image depicting patient anatomical data of at least a target region of patient tissue;mapping a prescribed dose of radiotherapeutic radiation onto the image as a desired dose distribution to be achieved in the target region;determining at least one beam angle corresponding to a direction from which the radiotherapeutic radiation is to be delivered from a source to the target region, wherein the source produces a directable beam of therapeutic radiation;creating a mask for each beam angle, the mask defining a beam outline substantially matching an outline of the target region as seen from each beam angle;discretizing each beam within its beam outline into a first plurality of pencil beams;performing a fluence optimization process for each beam angle using pencil beam data from the first plurality of pencil ...

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Номер записи: 43
14-01-2016 дата публикации

Targeted Isotope Production System

Номер: US20160012928A1
Автор: Congedo Thomas V., Guler Cenk, Heibel Michael D., Sutton Joanna C.
Принадлежит: WESTINGHOUSE ELECTRIC COMPANY LLC

A system and method for employing the in-core movable detectors of a commercial nuclear powered electric generating facility to transmute a user-specified target material into a desired isotope. The process is conducted remotely resulting in a shielded end product available for shipment for further processing. 1. A targeted isotope production system for a moveable in-core nuclear reactor detector system for mapping temperature or neutron flux in a core of a nuclear reactor , the in-core nuclear reactor detector system having a first multiple path linear transfer device that upon command , receives a detector and feeds the detector into a second multiple path linear transfer device that feeds the detector along a desired path to a selected radial core location , the second multiple path linear transfer device is alternately operable , upon command , to feed the detector through a storage conduit to a separate storage location , the targeted isotope production system comprising:a target material container drive assembly that is connected to an input to the first multiple path linear transfer device;a third multiple path linear transfer device that has an input that is connected to the storage conduit and upon command is operable to connect the storage conduit to one of at least two outlets on the third multiple path linear transfer device, a first of the two outlets is connected to the separate storage location and a second outlet; anda target material storage container is connected to a second of the two outlets on the third multiple path linear transfer device.2. The target isotope production system of wherein the target material storage container has a quick disconnect coupling connecting it to the second outlet.3. The target isotope production system of wherein the target material container drive assembly is a cable drive system to which the target material is attached.4. The target isotope production system of wherein the target material container drive assembly ...

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Номер записи: 44
10-01-2019 дата публикации

SWITCHABLE RADIATION SOURCE

Номер: US20190013109A1
Автор: Alajo Ayodeji B., Lee Hyoung K., Paaren Kyle
Принадлежит: The Curators of the University of Missouri

A switchable radiation source device includes a primary source assembly that emits primary radiation, and a target assembly in which, upon irradiation of the target assembly by the primary radiation, secondary radiation or radioactivity is produced. An alignment, proximity or exposure of the primary source assembly to the target assembly is adjustable to control irradiation of the target assembly by the primary radiation and thereby control the production of secondary radiation or radioactivity. 1. A switchable radiation source device comprising:a primary source assembly that emits primary radiation; anda target assembly in which, upon irradiation of the target assembly by the primary radiation, secondary radiation or radioactivity is produced;wherein an alignment, proximity or exposure of the primary source assembly to the target assembly is adjustable to control irradiation of the target assembly by the primary radiation and thereby control the production of secondary radiation or radioactivity.2. The switchable radiation source of claim 1 , wherein:the primary source assembly comprises at least one planar source tile;the target assembly comprises at least one planar target tile; andalignment of the source tile and target tile is adjustable by movement of the source tile or target tile.3. The switchable radiation source of claim 1 , wherein:the primary source assembly comprises at least one planar source tile;the target assembly comprises at least one planar target tile; andproximity of the source tile and target tile is adjustable by movement of the source tile or target tile.4. The switchable radiation source of claim 1 , wherein:the primary source assembly comprises a first planar array of separated multiple source tiles;the target assembly comprises a second planar array of separated multiple target tiles; andalignment of the source tiles and target tiles is adjustable by movement of at least one of the first planar array and second planar array.5. The ...

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Номер записи: 45
19-01-2017 дата публикации

SYSTEMS AND METHODS FOR PATIENT POSITION MONITORING

Номер: US20170014648A1
Автор: MOSTAFAVI Hassan
Принадлежит: Varian Medical Systems, Inc.

A method of monitoring a patient includes: obtaining an input image having a plurality of regions of interest by a processing unit; and determining a plurality of positions for the respective plurality of regions of interest by the processing unit; wherein the act of determining the plurality of positions comprises: accessing a plurality of templates; comparing the plurality of templates with respective areas in the input image using a comparator in the processing unit; and determining the plurality of positions based at least in part on a result of the act of comparing. 1. A method of monitoring a patient , comprising:obtaining an input image having a plurality of regions of interest by a processing unit; anddetermining a plurality of positions for the respective plurality of regions of interest by the processing unit; accessing a plurality of templates;', 'comparing the plurality of templates with respective areas in the input image using a comparator in the processing unit; and', 'determining the plurality of positions based at least in part on a result of the act of comparing., 'wherein the act of determining the plurality of positions comprises2. The method of claim 1 , wherein the act of comparing comprises performing template matching using the input image and a plurality of templates for the respective regions of interest.3. The method of claim 1 , wherein the act of comparing comprises performing a plurality of cross correlations between the areas in the input image and the plurality of templates.4. The method of claim 1 , further comprising creating the plurality of templates.5. The method of claim 4 , wherein the act of creating the plurality of templates comprises:obtaining a reference image;determining a plurality of points in the reference image; andgenerating the plurality of templates using pixels in the reference image, such that the templates have respective coordinates that correspond with respective positions of the determined points in the ...

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Номер записи: 46
18-01-2018 дата публикации

RADIOTHERAPY PLANNING APPARATUS, RADIOTHERAPY APPARATUS, AND RADIOTHERAPY PLANNING METHOD

Номер: US20180015304A1
Автор: OHISHI Satoru
Принадлежит: Toshiba Medical Systems Corporation

According to one embodiment, a radiotherapy planning apparatus includes processing circuitry. The processing circuitry calculates initial irradiation directions of particle beams and an initial dose distribution corresponding to the initial irradiation directions by using a three-dimensional medical image concerning an object. The processing circuitry disperses some or all of the initial irradiation directions in response to a dispersion instruction via an input device. The processing circuitry modifies the initial dose distribution based on the dispersed irradiation directions. 1. A radiotherapy planning apparatus comprising processing circuitry configured to calculate initial irradiation directions of particle beams and an initial dose distribution corresponding to the initial irradiation directions by using a three-dimensional medical image concerning an object ,disperse some or all of the initial irradiation directions in response to a dispersion instruction via an input device, andmodify the initial dose distribution based on the dispersed irradiation directions.2. The radiotherapy planning apparatus of claim 1 , wherein the processing circuitry calculates the initial irradiation directions of particle beams corresponding to a predetermined number of times of irradiation at substantially the same position and in the same direction and the initial dose distribution corresponding to the initial irradiation directions.3. The radiotherapy planning apparatus of claim 2 , wherein the processing circuitry disperses the predetermined number of times of the initial irradiation directions to separate the initial irradiation directions from each other by a predetermined angle.4. The radiotherapy planning apparatus of claim 3 , wherein the predetermined number of times is not more than five.5. The radiotherapy planning apparatus of claim 3 , wherein the predetermined angle is not more than 5°.6. The radiotherapy planning apparatus of claim 3 , further comprising a storage ...

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Номер записи: 47
15-01-2015 дата публикации

TREATMENT SYSTEM, CONTROL DEVICE AND TREATMENT METHOD

Номер: US20150018595A1
Автор: MITA Takeshi, SAKATA Yukinobu, Taguchi Yasunori, Takeguchi Tomoyuki
Принадлежит:

According to an embodiment, a treatment system includes a plurality of first radiators, a plurality of detectors, a determiner, and a controller. Each of the first radiators irradiates a radioactive beam to a subject. Each of the detectors detects a radioactive beam transmitted through the subject and generates an image based on the detected radioactive beam. The determiner determines whether an object in the subject is included in a first region using a given image that is one of the images. The controller controls the first radiators so that, when the object is not included in the first region, a smaller amount of radioactive beams is irradiated per unit time than when the object is included in the first region. 1. A treatment system comprising:a plurality of first radiators that each irradiates a radioactive beam to a subject;a plurality of detectors that each detects a radioactive beam transmitted through the subject and each generates an image based on the detected radioactive beam;a determiner that determines whether an object in the subject is included in a first region using a given image that is one of the images; anda controller that controls the first radiators so that, when the object is not included in the first region, a smaller amount of radioactive beams is irradiated per unit time than when the object is included in the first region.2. The system according to claim 1 , further comprising a second radiator that irradiates a treatment beam claim 1 , whereinwhen the object is included in the first region, the determiner further determines whether the object is included in a second region using the images, andwhen the object is included in the second region, the second radiator irradiates the treatment beam to the object.3. The system according to claim 2 , wherein the first region is obtained by projecting the second region on the given image.4. The system according to claim 3 , wherein the determiner determines that the object is included in the first ...

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Номер записи: 48
16-01-2020 дата публикации

SHIELDING ASSEMBLY FOR A RADIOISOTOPE DELIVERY SYSTEM HAVING MULTIPLE RADIATION DETECTORS

Номер: US20200016284A1
Автор: CHERUNDOLO Brian, DENNIS Joseph, MOYERS Clif, NUNN Adrian, SCHIMMOELLER Andrew
Принадлежит:

A shielding assembly may be used in a nuclear medicine infusion system that generates and infuse radioactive liquid into a patient undergoing a diagnostic imaging procedure. In some examples, the shielding assembly has multiple compartments each formed of a shielding material providing a barrier to radioactive radiation. For example, the shielding assembly may have a first compartment configured to receive a radioisotope generator that generates a radioactive eluate via elution, a second compartment configured to receive a beta detector, and a third compartment configured to receive a gamma detector. In some examples, the compartments are arranged to minimize background radiation emitted by the radioisotope generator and detected by the gamma detector to enhance the quality of the measurements made by the gamma detector. 1. A system comprising: a first compartment configured to receive a radioisotope generator that generates a radioactive eluate via elution;', 'a second compartment configured to receive a beta detector, and', 'a third compartment configured to receive a gamma detector., 'a shielding assembly that has a plurality of compartments each formed of a shielding material providing a barrier to radioactive radiation, comprising2. The system of claim 1 , wherein the third compartment is configured to receive an eluate-receiving container such that both the gamma detector and the eluate-receiving container can be positioned in the third compartment.3. The system of claim 2 , wherein the third compartment comprises a sidewall defining an opening through which the eluate-receiving container can be inserted.4. The system of claim 3 , wherein the gamma detector is positioned to detect gamma emissions emitted by a static portion of the radioactive eluate received by the eluate-receiving container.5. The system of claim 3 , further comprising a removable insert positioned in the opening claim 3 , wherein the removable insert defines a cavity configured to receive ...

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Номер записи: 49
16-01-2020 дата публикации

Nitinol Organ Positioner to Prevent Damage to Healthy Tissue During Radiation Oncology Treatments

Номер: US20200016433A1
Автор: ELAHINIA Mohammad, Parsai E. Ishmael
Принадлежит: The University of Toledo

Devices, systems, and methods for repositioning organs, such as the rectum, during radiation therapy treatments, are described. 1. A method of repositioning an organ , the method comprising:inserting an organ repositioner device into an anatomical location, wherein the organ repositioner device comprises an assembly of a shape memory (SM) element and a superelastic (SE) element, the SM element and the SE element comprising memory shape alloys; andactuating the assembly to cause the organ repositioner device to reposition an organ near the anatomical location.2. The method of claim 1 , wherein the actuation is caused by cooling the assembly.3. The method of claim 1 , wherein the actuation is caused by heating the assembly.4. The method of claim 1 , further comprising monitoring the actuation of the assembly by measuring electrical resistance in the assembly.5. The method of claim 1 , wherein the actuation is controlled using an artificial neural network.6. The method of claim 1 , further comprising administering a radiation therapy to or nearby the anatomical location.7. A method of repositioning an organ for a radiation treatment claim 1 , the method comprising:positioning an organ repositioner device in a first configuration in an anatomical location;cooling or heating the organ repositioner device to deform the organ repositioner into a second configuration, wherein deformation into the second configuration causes the organ repositioner device to reposition an organ at or near the anatomical location; andsensorlessly monitoring the deformation of the organ repositioner device by measuring electrical resistance in the organ respositioner.8. The method of claim 7 , further comprising administering a radiation treatment to or nearby the anatomical location.9. The method of claim 7 , wherein the organ repositioner device comprises an assembly of two memory shape alloys.10. The method of claim 9 , wherein the assembly comprises a superelastic (SE) element and a shape ...

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Номер записи: 50
21-01-2021 дата публикации

SETUP METHOD AND APPARATUS, DATA PROCESSING DEVICE, AND RADIOTHERAPY SYSTEM

Номер: US20210016110A1
Автор: Gou Tianchang, LI Jinsheng, YAN Hao
Принадлежит:

Provided is a setup method which can include: acquiring a position of a reference mark point provided on a noninvasive positioning device in an infrared coordinate system of an infrared positioning system; according to the position of the reference mark point in the infrared coordinate system, a relative position between the reference mark point and an image center point in an electronic scanning image, and a position of an isocenter of a radiotherapy equipment in a patient supporting device PSD coordinate system of the radiotherapy equipment, determining a first offset between the image center point and the isocenter in the PSD coordinate system; and adjusting the first offset to a first target offset by adjusting a position of a patient supporting device in the PSD coordinate system. 1. A setup method , comprising:acquiring, at a setup stage, a position of a reference mark point provided on a noninvasive positioning device in an infrared coordinate system of an infrared positioning system;according to the position of the reference mark point in the infrared coordinate system, a relative position between the reference mark point and an image center point in an electronic scanning image, and a position of an isocenter of a radiotherapy equipment in a patient supporting device PSD coordinate system of the radiotherapy equipment, determining a first offset between the image center point and the isocenter in the PSD coordinate system; andadjusting the first offset to a first target offset by adjusting a position of a patient supporting device in the PSD coordinate system.2. The method according to claim 1 , wherein determining the first offset between the image center point and the isocenter in the PSD coordinate system according to the position of the reference mark point in the infrared coordinate system claim 1 , the relative position between the reference mark point and the image center point in the electronic scanning image claim 1 , and the position of the ...

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Номер записи: 51
19-01-2017 дата публикации

FAST BURST AND STEADY-STATE INTENSE NEUTRON SOURCE

Номер: US20170018318A1
Автор: Campbell Logan, Moll Eli, Ozburn David, Radel Ross, Schneider Dave, Sengbusch Evan
Принадлежит: Phoenix Nuclear Labs LLC

A first system for producing a high flux of neutrons for non-destructive testing includes a dense plasma focus device neutronically coupled to a subcritical or sub-prompt critical fission assembly. The dense plasma focus device is a source of initiating neutrons for the fission assembly, and the fission assembly is configured to multiply a number of the initiating neutrons via inducing fission. A second system for producing a high flux of neutrons includes a gas-target neutron generator neutronically coupled to a subcritical or sub-prompt critical fission assembly. The gas-target neutron generator is a source of initiating neutrons for the fission assembly, and the fission assembly is configured to multiply a number of the initiating neutrons via inducing fission. 1. A system for producing a high flux of neutrons , the system comprising: a cylindrical anode disposed within and concentric to the cathode;', 'an insulator provided between portions of the cathode and the anode, the insulator disposed proximate to the input end of the dense plasma focus device; and', 'a chamber bounded by the cathode and the anode, the chamber being pressurized with a fill gas; and, 'a dense plasma focus device having an input end and an output end, the dense plasma focus device including a cylindrical cathode;'}a fission assembly neutronically coupled to the dense plasma focus device,wherein the fission assembly is a subcritical or a sub-prompt critical fission assembly, andwherein the dense plasma focus device is a source of initiating neutrons for the fission assembly, and the fission assembly is configured to multiply a number of the initiating neutrons via inducing fission.2. The system of claim 1 , wherein the fill gas comprises a deuterium-tritium gas mixture.3. The system of claim 1 , wherein a pressure of the fill gas is static at 1-100 Torr.4. The system of claim 1 , wherein a pressure of the fill gas is dynamically raised at a pinch formed at a center of a tip of the anode by ...

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Номер записи: 52
17-04-2014 дата публикации

PORTABLE ORTHOVOLTAGE RADIOTHERAPY

Номер: US20140105362A1
Автор: Gertner Michael
Принадлежит: Oraya Therapeutics, Inc.

A portable orthovoltage radiotherapy system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. 122-. (canceled)23. A treatment system , comprising:an eye contact member, configured to contact an outer surface of an eye, the eye contact member comprising a fiducial marker;a radiation source, configured to emit a beam of radiation; anda control system configured to (i) identify a mapped location, based on imaging data, of a target region within the eye relative to a location of the fiducial marker and (ii) position, based on the mapped location, the radiation source to direct the beam to the target region.24. The treatment system of claim 23 , wherein the target region comprises a macula of the eye.25. The treatment system of claim 23 , wherein the radiation source is coupled to a collimator.26. The treatment system of claim 23 , wherein the radiation source is configured to emit the beam with a cross-sectional width of less than about 6 mm.27. The treatment system of claim 23 , wherein the control system is operably connected to an electromechanical actuation system for positioning the radiation source.28. The treatment system of claim 23 , wherein the control system is operably connected to a wheel or shaft for positioning the radiation source.29. The treatment system of claim 23 , wherein the control system is operably connected to a shutter system for controlling emission of the beam.30. The treatment system of claim 23 , wherein the control system is further configured to detect a movement of ...

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Номер записи: 53
28-01-2016 дата публикации

IMAGING BASED CALIBRATION SYSTEMS, DEVICES, AND METHODS

Номер: US20160023019A1
Автор: FILIBERTI RETO W., Gaudio Stephen
Принадлежит:

Systems, devices, and methods for imaging-based calibration of radiation treatment couch position compensations. 1. An imaging-based calibration method for a radiation treatment system including a gantry and a treatment couch , the method comprising:generating gantry-angle dependent isocenter beam deviation information;generating couch rotation-angle dependent couch position offset information; andcorrecting target position by combining the gantry-angle dependent isocenter beam deviation information with the couch rotation-angle dependent couch position offset information.2. The method of claim 1 , wherein the generating of the gantry-angle dependent isocenter beam deviation information includes:acquiring X-ray images of a calibration device at a plurality of gantry angles;determining deviations of the isocenter for all gantry angles from the X-ray images; anddetermining the position of the target for each gantry angle based on the corresponding isocenter deviation.3. The method of claim 1 , wherein the generating of the couch rotation-angle dependent couch position offset information includes:acquiring a plurality of X-ray images of a calibration device positioned on the treatment couch, the couch being rotated over a couch rotation range;determining positions of the calibration device at a plurality of rotation angles from corresponding X-ray images;translating each determined calibration device position to a couch location;comparing the acquired couch locations with corresponding reference couch locations; andcalculating a couch position offset value for each couch rotation angle based on a result of the comparison.4. The method of claim 3 , wherein the reference couch locations for all couch rotation angles are determined using a camera-based system or a couch readout system.5. The method of claim 4 , wherein the couch readout system includes a potentiometer claim 4 , or an optical or magnetic angle or linear encoder.6. The method of claim 3 , wherein the ...

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Номер записи: 54
26-01-2017 дата публикации

RADIOTHERAPY AND IMAGING APPARATUS

Номер: US20170021196A1
Автор: Allen John, Brown Kevin
Принадлежит:

A radiotherapy system comprises a patient support, moveable along a translation axis, an imaging apparatus, comprising a first magnetic coil and a second magnetic coil, the first and second magnetic coils having a common central axis parallel to the translation axis, and being displaced from one another along the central axis to form a gap therebetween, the imaging apparatus being configured to obtain an image of a patient on the patient support, a source of radiation mounted on a chassis, the chassis being rotatable about the central axis and the source being adapted to emit a beam of radiation through the gap along a beam axis that intersects with the central axis, a multi-leaf collimator comprising a plurality of elongate leaves movable between at least a withdrawn position in which the leaf lies outside the beam, and an extended position in which the leaf projects across the beam, and a radiation detector mounted to the chassis opposite the source, the radiation detector having a plurality of detector elements aligned with the elongate leaves when projected onto an isocentric plane. 1. A radiotherapy system comprising:a patient support, moveable along a translation axis;an imaging apparatus, comprising a first magnetic coil and a second magnetic coil, the first and second magnetic coils having a common central axis parallel to the translation axis, and being displaced from one another along the central axis to form a gap therebetween, the imaging apparatus being configured to obtain an image of a patient on the patient support;a source of radiation mounted on a chassis, the chassis being rotatable about the central axis and the source being adapted to emit a beam of radiation through the gap along a beam axis that intersects with the central axis;a multi-leaf collimator comprising a plurality of movable elongate leaves; and 'having a plurality of detector elements arranged in columns, each of the columns being superimposed with a respective elongate leaf of the ...

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Номер записи: 55
25-01-2018 дата публикации

X-Ray Patient Position Monitoring

Номер: US20180021597A1
Автор: Berlinger Kajetan, REHS Jorg
Принадлежит:

A data processing method performed by a computer for monitoring the position of a patient, comprising the steps of: acquiring a 3D image dataset of the patient; acquiring an initial real image of the patient from a medical imaging system having a known and fixed location in space, thus defining a known viewing direction of the initial real image in space, the real image being taken at a first point in time; —performing 2D/3D registration by calculating a simulated image from the 3D image dataset which matches the initial real image best, the simulated image having a viewing direction onto the 3D image dataset; storing an initial similarity measure value for the pair of the initial real image and the calculated simulated image; —acquiring a subsequent real image from the medical imaging system taken at a second point in time later than the first point in time; calculating a subsequent similarity measure value for the pair of the subsequent real image and the calculated simulated image; and outputting an indication signal if the difference between the initial similarity measure value and the subsequent similarity measure value fulfills a predetermined criterion. 115.-. (canceled)16. A computer implemented method for monitoring the position of a patient , comprising:acquiring a 3D image dataset of the patient;acquiring an initial real image of the patient from a medical imaging system having a known and fixed location in space, thus defining a known viewing direction of the initial real image in space, the real image being taken at a first point in time;performing 2D/3D registration by calculating a simulated image from the 3D image dataset which substantially matches the initial real image, the simulated image having a viewing direction onto the 3D image dataset;storing an initial similarity measure value for the pair of the initial real image and the calculated simulated image;acquiring a subsequent real image from the medical imaging system taken at a second point ...

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Номер записи: 56
25-01-2018 дата публикации

RADIOTHERAPY APPARATUS

Номер: US20180021598A1
Автор: Bergfjord Per Harald
Принадлежит:

A radiotherapy apparatus includes a fixed support and a gantry including a chassis part and a source part, the chassis part being rotatably attached to the fixed support to allow rotation thereof about a generally horizontal axis, and the source part being connected to the chassis part via a rotatable connection allowing the source part to rotate relative to the chassis part around a transverse axis. The source part includes a source of therapeutic radiation directed towards the intersection of the transverse axis and the horizontal axis. The chassis part and the source part together define an annular ring that encircles the horizontal axis. In this way, the radiotherapy apparatus can provide the full usual range of treatments, but can also adapt itself to adopt a non-coplanar geometry when required, for example to treat difficult locations in the head and neck. 1. A radiotherapy apparatus , comprising:a fixed support, and wherein the chassis part is rotatably attached to the fixed support such that the chassis part is configured to rotate about a horizontal axis, and', 'wherein the source part is connected to the chassis part via at least one rotatable connection such that the source part is configured to rotate relative to the chassis part around a transverse axis which is aligned transverse to and intersecting with the horizontal axis;, 'a gantry comprising a chassis part and a source part,'}wherein the source part comprises a source of therapeutic radiation directed towards the intersection of the transverse axis and the horizontal axis;wherein the chassis part and the source part define an annular ring that encircles the horizontal axis.2. The radiotherapy apparatus of claim 1 , wherein the source part includes a collimation apparatus for the therapeutic radiation.3. The radiotherapy apparatus of claim 1 , wherein the chassis part further comprises a source of diagnostic radiation and a detector for the diagnostic radiation.4. The radiotherapy apparatus of ...

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Номер записи: 57
24-01-2019 дата публикации

TRIGGERED TREATMENT SYSTEMS AND METHODS

Номер: US20190022416A1
Автор: Abel Eric, Kaissl Wolfgang, Khuntia Deepak, Noel Camille, Smith Christel, STAR-LACK Josh, Timmer Jan Hein, ZANKOWSKI Corey
Принадлежит:

In various embodiments, a radiation therapy method can include loading a planning image of a target in a human. In addition, the position of the target can be monitored. A computation can be made of an occurrence of substantial alignment between the position of the target and the target of the planning image. Furthermore, after the computing, a beam of radiation is triggered to deliver a dosage to the target in a short period of time (e.g., less than a second). 1. A radiation therapy method comprising:loading a planning image of a target in a human;monitoring the position of said target;computing an occurrence of substantial alignment between the position of said target and said target of said planning image, said computing comprises utilizing a sum of a real-time deformation vector-field; andafter said computing, triggering a beam of radiation to deliver a dosage to said target in less than a second.2. The method of claim 1 , wherein said planning image comprises a magnetic resonance imaging (MRI) image.3. The method of claim 1 , wherein said monitoring comprises performing fluoroscopy.4. The method of claim 1 , wherein said planning image comprises a computed tomography (CT) image.5. The method of claim 1 , wherein said triggering is performed manually by a human.6. The method of claim 1 , wherein said computing comprises a visual representation of said sum of said real-time deformation vector-field.7. The method of claim 1 , wherein said monitoring comprises generating a real-time image of said target.8. The method of claim 1 , wherein said computing comprises a visual representation comprising a bar graph.9. A radiation therapy method comprising:loading a planning image of a target in a human;monitoring the position of said target;mapping said target in both said monitoring and said planning image;computing an occurrence of substantial alignment between the position of said target and said target of said planning image, said computing comprises utilizing a sum ...

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Номер записи: 58
24-01-2019 дата публикации

BEAM SHAPING ASSEMBLY FOR NEUTRON CAPTURE THERAPY

Номер: US20190022421A1
Автор: LEE Pei-Yi, Liu Yuan-Hao
Принадлежит:

Abeam shaping assembly for neutron capture therapy includes a beam inlet, a target having nuclear reaction with an incident proton beam from the beam inlet to produce neutrons forming a neutron beam defining a main axis, a moderator adjoining to the target, a reflector surrounding the moderator, a thermal neutron absorber adjoining to the moderator, a radiation shield arranged inside the beam shaping assembly and a beam outlet. The neutrons are moderated to epithermal neutron energies. The reflector leads the neutrons deviated from the main axis back, and a gap channel is arranged between the moderator and the reflector. The thermal neutron absorber is used for absorbing thermal neutrons so as to avoid overdosing in superficial normal tissue during therapy. The radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation. 1. A beam shaping assembly for neutron capture therapy comprising:a beam inlet;a target, wherein the target has nuclear reaction with an incident proton beam from the beam inlet to produce neutrons, and wherein the neutrons form a neutron beam defining a main axis;a moderator adjoining to the target, wherein the neutrons are moderated by the moderator to epithermal neutron energies, the moderator includes a first side facing to the beam inlet and a second side facing away from the beam inlet;a reflector surrounding the moderator, wherein the reflector leads the neutrons deviated from the main axis back to enhance epithermal neutron beam intensity;a radiation shield arranged inside the beam shaping assembly, wherein the radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation; anda beam outlet,wherein the target is received into the moderator, the first side of the moderator contacts with the reflector.2. The beam shaping assembly for neutron capture therapy according to claim 1 , wherein the ...

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Номер записи: 59
25-01-2018 дата публикации

PUMP FOR OPERATION IN RADIOACTIVE ENVIRONMENT

Номер: US20180023555A1
Автор: Graves Kevin B., Petrofsky Bryan S.
Принадлежит:

A method of assembling a pump for use in a radioactive environment includes positioning tubing between a rotor and a clamp of the pump. The pump includes a pump head that includes a casing, the rotor, and the clamp. The rotor rotates in relation to the casing. The method also includes rotating the rotor for a first period to compress the tubing against the rotor. The tubing is in a dry condition throughout the first period. The method further includes directing liquid into the tubing and rotating the rotor for a second period to compress the tubing against the rotor and direct the liquid through the pump head. The method also includes calibrating the pump. 1. A method of assembling a pump for use in a radioactive environment , the pump including a pump head that includes a casing , a rotor , and a clamp , the rotor rotating in relation to the casing , the method comprising:positioning tubing between the rotor and the clamp, wherein the tubing is in a dry condition;rotating the rotor for a first period to compress the tubing against the rotor, wherein the tubing is in the dry condition throughout the first period;directing liquid into the tubing;rotating the rotor for a second period to compress the tubing against the rotor and direct the liquid through the pump head; andcalibrating the pump.2. The method of claim 1 , wherein rotating the rotor to compress the tubing against the rotor comprises rotating the rotor at a speed of at least 300 revolutions per minute.3. The method of claim 2 , wherein rotating the rotor to compress the tubing against the rotor comprises rotating the rotor for at least 6 claim 2 ,000 cumulative seconds.4. The method of further comprising dispensing liquid from the pump claim 1 , wherein the liquid is dispensed in discrete shots.5. The method of claim 4 , wherein dispensing liquid from the pump comprises dispensing at least 1 claim 4 ,000 shots claim 4 , and each shot includes approximately 10 milliliters.6. The method of further comprising ...

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Номер записи: 60
24-01-2019 дата публикации

CONVEYANCE SYSTEM FOR OPERATION IN RADIOACTIVE ENVIRONMENT

Номер: US20190023494A1
Автор: "DHooge Michael J.", Graves Kevin B., Petrofsky Bryan S., Verma Sumit
Принадлежит:

A system for manufacturing radionuclide generators includes an enclosure defining a radioactive environment. The enclosure includes radiation shielding to prevent radiation within the radioactive environment from moving to an exterior of the enclosure. The system also includes a conveyance system having a forward track and first carriages positioned on and movable along the forward track for conveying racks in a first direction. The conveyance system also includes a first walking beam mechanism magnetically coupled to the first carriages to move the first carriages. The conveyance system further includes a return track and second carriages positioned on and movable along the return track for conveying racks in a second direction opposite the first direction. The forward track and the return track form a loop. 1. A conveyance system for operation in an enclosed radioactive environment , the conveyance system comprising:a track;carriages positioned on and moveable along the track for conveying racks along the track;a walking beam mechanism magnetically coupled to the carriages to move the carriages along the track;a lift mechanism for lifting the racks off the carriages, the lift mechanism moveable between an extended position and a retracted position;a first sensor located to track the position of the carriages and racks along the track; anda second sensor located to detect whether the lift mechanism is in the extended position or the retracted position.2. The conveyance system of claim 1 , wherein the first sensor is located below the track and the second sensor is located adjacent the lift mechanism.3. The conveyance system of claim 1 , wherein the second sensor comprises a sensor mechanism including at least one of a mechanical switch and a magnetically-actuated electrical contact.4. The conveyance system of claim 3 , wherein the second sensor comprises a housing defining an interior that contains wiring connected to the sensor mechanism claim 3 , the system ...

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Номер записи: 61
23-01-2020 дата публикации

METHOD OF IRRADIATING A TARGET

Номер: US20200023197A1
Автор: AUSTIN Kevin Murray, Brown David A., BROWN Peter W.A., FORKNALL Simon J., HEPWORTH David J., MACRILLO David M.
Принадлежит:

A method of irradiating a target with a high power density irradiation beam is described. The method can use an irradiation system configured to output an irradiation beam through a vacuum window. The irradiation beam is scanned repetitively back and forth between two angular orientations of the irradiation beam as the irradiation beam strikes and traverses the vacuum window. The target is moved as the irradiation beam is scanned. The irradiation beam and the target are aligned. The scanning of the irradiations beam and the moving of the target are synchronized to each other. The scanning of the irradiation beam prevents localized overheating of the vacuum window and allows the irradiation beam to have a power density that would damage the vacuum window if the irradiation beam were not scanned. 1. A method of irradiating a target , the method comprising:scanning an irradiation beam repetitively back and forth between two angular orientations of the irradiation beam as the irradiation beam strikes a vacuum window and traverses the vacuum window;moving, along a straight line, the target repetitively back and forth between two target positions;aligning the target and the irradiation beam to each other;synchronizing, to each other, the scanning of the irradiation beam and the moving of the target along the straight line to maintain alignment between the irradiation beam and the target during the scanning of the irradiation beam and the moving of the target;shutting down the irradiation beam when a stop criterion is met.2. The method of claim 1 , wherein:the irradiation beam has an areal power density;the vacuum window has an areal power density threshold beyond which the vacuum window fails when subjected to, at a fixed position on the vacuum window, the power density beyond a pre-determined irradiation duration;the scanning of the irradiation beam between the two angular orientations of the irradiation beam results in a delivered power density lower than the power ...

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Номер записи: 62
23-01-2020 дата публикации

BEAM SHAPING ASSEMBLY FOR NEUTRON CAPTURE THERAPY

Номер: US20200023205A1
Автор: CHANG Ming-Chuan, Chen Wei-Lin, LEE Pei-Yi, Liu Yuan-Hao, XU Wenyu
Принадлежит:

A beam shaping assembly for neutron capture therapy includes a beam inlet, a target having nuclear reaction with an incident proton beam from the beam inlet to produce neutrons forming a neutron beam, a moderator adjoining to the target, a reflector surrounding the moderator, a thermal neutron absorber adjoining to the moderator, a radiation shield arranged inside the beam shaping assembly and a beam outlet. The material of the moderator is subjected to a powder sintering process using a powder sintering device so as to change powders or a power compact into blocks. The reflector leads the neutrons deviated from the main axis back. The thermal neutron absorber is used for absorbing thermal neutrons so as to avoid overdosing in superficial normal tissue during therapy. The radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation. 1. A beam shaping assembly for neutron capture therapy comprising:a beam inlet;a target, wherein the target has nuclear reaction with an incident proton beam from the beam inlet to produce neutrons, and wherein the neutrons form a neutron beam defining a main axis;{'sub': 4', '2', '3', '3', '2', '2, 'sup': '6', 'a moderator adjoining to the target, wherein the neutrons are moderated by the moderator to epithermal neutron energies, the material of the moderator is prepared by mixing a mixture containing one or more of PbF, AlO, AlF, CaFand MgFand a Li element-containing material accounting for 0.1 to 5% in percentage by weight of the mixture;'}a reflector surrounding the moderator, wherein the reflector leads the neutrons deviated from the main axis back to enhance epithermal neutron beam intensity;a radiation shield for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation; anda beam outlet.2. The beam shaping assembly for neutron capture therapy according to claim 1 , wherein the Li element-containing ...

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Номер записи: 63
02-02-2017 дата публикации

Image-Guided Radiation Therapy

Номер: US20170028221A1
Автор: BOL Gijsbert Herman, KONTAXIS Charis, RAAYMAKERS Bas Willem
Принадлежит: ELEKTA AB (PUBL)

The disclosed systems and methods for Image-Guided Radiation Therapy (IGRT), utilises an iterative approach which adjusts a treatment plan based on inter- or intra-fraction images to improve the accuracy of the radiation delivered during the overall treatment. The prescribed dose of radiotherapeutic radiation is mapped onto the patient's anatomy using an image acquired of the region, which is to be the target for radiotherapeutic radiation. Following beam-angle-optimisation, fluence optimisation and segmentation, the efficiency of delivery of each segment is determined using an objective function, and the segments ranked according to their efficiency. The plan proceeds with the choice of the most efficient segment (or segments) to be delivered first. When this radiation has been delivered, having been tracked to establish its distribution, this delivered distribution can be subtracted from the original prescribed dose and the process repeated so that the delivered radiation gradually converges on the original prescribed dose. 1. A radiotherapeutic apparatus for delivering a prescribed dose of radiotherapeutic radiation to a target region of patient tissue comprising a source for producing a directable beam of therapeutic radiation , wherein an image depicting patient anatomical data of at least the target region has been acquired and the prescribed dose has been mapped onto the image as the desired dose distribution to be achieved in the target region , the apparatus being adapted and configured to:a) determine at least one beam angle corresponding to a direction from which the radiotherapeutic radiation is to be delivered from the source to the target region, and for each beam angle create a mask defining a beam outline which substantially matches an outline of the target region as seen from each beam angle;b) discretize the or each beam within its beam outline into a plurality of pencil beams;c) for each beam angle carry out a fluence optimisation process using ...

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Номер записи: 64
04-02-2016 дата публикации

RETROSPECTIVE CALCULATION OF RADIATION DOSE AND IMPROVED THERAPY PLANNING

Номер: US20160030770A1
Автор: Boernert Peter, Nielsen Tim, Overweg Johannes Adrianus, Uhlemann Falk
Принадлежит:

A combined magnetic resonance (MR) and radiation therapy system includes a bore-type magnet with a magnet radiation translucent region which allows radiation beams to travel radially through the magnet and a split-type gradient coil includes a gradient coil radiation translucent region aligned to the magnet radiation translucent region. A radiation source, disposed laterally to the magnet, administers a radiation dose through the magnet and gradient coil radiation translucent regions to an examination region. A dosage unit determines the actual radiation dose delivered to each voxel of a target volume and at least one non-target volume based on a pre-treatment, intra-treatment, and/or post-treatment image representation of the target volume and the at least one non-target volume. A planning processor updates at least one remaining radiation dose of a radiation therapy plan based on the determined actual radiation dose. 1. A computer-implemented method for radiation dose delivery , the method comprising:generating, by a processor, a radiation therapy plan, wherein the radiation therapy plan includes a plurality of radiation doses;acquiring, by the processor, a pre-treatment image representation of a target volume and non-target volumes;determining, by the processor, a contour and position of the target volume and at least one non-target volume based on the pre-treatment image representation;administering, by the processor, the radiation dose, wherein the radiation dose includes a plurality of radiation beam trajectories and at least one radiation beam geometry; anddetermining, by the processor, an actual radiation dose delivered to each region of the target volume and the at least one non-target volume based on their determined contours and positions, the radiation beam trajectories, and the at least one radiation beam geometry.2. The method according to claim 1 , further including:prior to administering the radiation dose, aligning the determined position of the ...

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Номер записи: 65
23-01-2020 дата публикации

LOW DENSITY IRIDIUM

Номер: US20200027621A1
Автор: SHILTON Mark
Принадлежит:

The disclosure pertains to improvements in a gamma radiation source, typically containing low-density alloys or compounds or composites of iridium in mechanically deformable and compressible configurations, within a sealed encapsulation, and methods of manufacture thereof. 1. A radiation , radiological or radiographic source including a mechanically depressible , compressible non-solid configuration of:an alloy or mixture of iridium, manganese and an element chosen from a group consisting of aluminum, copper and mixtures thereof; oran alloy or mixture of iridium and yttrium.2. The radiation claim 1 , radiological or radiographic source of wherein the alloy or mixture comprises IrMnAl.3. The radiation claim 1 , radiological or radiographic source of wherein at least a portion of the iridium comprises Iridium-192.4. The radiation claim 1 , radiological or radiographic source of wherein the alloy or mixture further includes an element chosen from the group consisting of platinum claim 1 , osmium claim 1 , chromium or mixtures thereof.5. The radiation claim 1 , radiological or radiographic source of claim 1 , including at least a first element and a second element claim 1 , with a mechanically compressible portion between the first element and the second element claim 1 , whereby force on the radiation claim 1 , radiological or radiographic source causes the first element to move toward the second element.6. The radiation claim 1 , radiological or radiographic source of claim 1 , including at least a first element claim 1 , a second element and a third element claim 1 , with a first mechanically compressible portion between the first element and the second element and a second mechanically compressible portion between the second element and the third element.7. The radiation claim 6 , radiological or radiographic source of wherein the first claim 6 , second and third elements are respective first claim 6 , second and third rings or disks claim 6 , and wherein the second ...

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Номер записи: 66
01-02-2018 дата публикации

RADIATION EMITTING APPARATUS, RADIATION THERAPY APPARATUS, AND COLLIMATOR DRIVE CONTROL METHOD

Номер: US20180028839A1
Автор: Oyamada Atsuyuki, YOSHIMIZU Eiki
Принадлежит: Accuthera Inc.

A radiation emitting apparatus includes a radiation source to generate radiation, a first collimator to define a maximum radiation field of the radiation; a second collimator to regulate the radiation field and direction of irradiation; a swing portion that swings in two directions orthogonal to each other; a displacement detector to detect displacement of the second collimator relative to a reference point; a drive mechanism to drive the swing portion; a control unit to control the drive mechanism; and a storage unit included in the control unit to store one or more parameters related to mechanical movement of the swing portion. The control unit generates feedforward control information based on an inputted target swing angle, a detected displacement, and the one or more parameters stored in the storage unit, and outputs a drive signal containing the feedforward control information to the drive mechanism. 1. A radiation emitting apparatus , comprising:a radiation source to generate radiation;a first collimator to define a maximum radiation field of the radiation;a second collimator to regulate the radiation field and direction of irradiation, the second collimator disposed within the first collimator;a swing portion, incorporating the second collimator, that swings in two directions orthogonal to each other, the swing portion having a rotational center and a center of gravity;a displacement detector to detect displacement of the second collimator relative to a reference point;a drive mechanism operatively connected to the swing portion to drive the swing portion;a control unit operatively connected to the drive mechanism to generate feedforward control information to control the drive mechanism; anda storage unit included in the control unit to store one or more parameters related to mechanical movement of the swing portion,the control unit generating feedforward control information based on an inputted target swing angle, a detected displacement, and the one or ...

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Номер записи: 67
01-02-2018 дата публикации

BEAM ANGLE DIRECTION DETERMINATION

Номер: US20180028840A1
Автор: Kozelka Jakub, Shi Jie, Simon William E., Wundke Kai
Принадлежит: SUN NUCLEAR CORPORATION

A system is disclosed that includes a radiation therapy device with a gantry. The radiation therapy device is configured to deliver a radiation beam at an angle determined by orientation of the gantry. Also, a pair of radiation detectors are located at a fixed position to receive radiation originating from the radiation beam. Each of the radiation detectors in the pair generate differing responses to the radiation beam at the angle. The system further includes computer hardware configured to perform operations that determine the angle of the gantry utilizing the differing responses from the pair of radiation detectors. 1. A system comprising:a radiation therapy device with a gantry, the radiation therapy device configured to deliver a radiation beam at an angle determined by orientation of the gantry;a pair of radiation detectors located at a fixed position to receive radiation originating from the radiation beam, each of the radiation detectors in the pair generating differing responses to the radiation beam at the angle; and 'determining the angle of the gantry utilizing the differing responses from the pair of radiation detectors.', 'computer hardware configured to perform operations comprising2. The system of wherein the computer hardware is further configured to display the determined angle claim 1 , to compare the determined angle to a planned angle claim 1 , or to use the determined angle in a dose calculation.3. The system of wherein the fixed position of the pair of radiation detectors is within the radiation beam.4. The system of wherein the fixed position of the pair of radiation detectors is outside of the radiation beam and the pair of radiation detectors detect scattered radiation.5. The system of wherein the pair of radiation detectors are mounted on a single substrate.6. The system of wherein the pair of radiation detectors are mounted on different substrates.7. The system of wherein the radiation detectors in the pair are oriented in opposite ...

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Номер записи: 68
28-01-2021 дата публикации

METHOD OF PRODUCING ACTINIUM BY LIQUEFIED RADIUM

Номер: US20210027906A1
Автор: KANG Joo Hyun, Lee Kyo Chul, Lim Sang Moo, OH Se Young
Принадлежит:

A method of producing actinium by using liquefied radium can minimize loss of Ra-226 according to the state change of Ac-225 by producing Ac-225 using Ra-226 of a liquefied state, moving the produced Ac-225 in a liquefied state after Ac-225 is produced, and separating and reusing Ac-225, thereby enabling a nuclear reaction process of Ac-225 to be performed. Further, a method of producing actinium by using liquefied radium according to the present disclosure has an effect of enabling safety to be improved by including a radon collection unit which is capable of discharging and isolating radon produced from Ra-226, thereby preventing radiation exposure due to radon. 1. A method of producing actinium by using liquefied radium , the method comprising step of;a step of moving the liquefied radium to load the liquefied radium into a reaction space inside a chamber;a step of producing actinium through a nuclear reaction process by irradiating a particle beam to the liquefied radium of the reaction space inside the chamber; andan unloading step of moving a product comprising the liquefied radium and actinium to the outside of the chamber.2. The method of claim 1 , further comprising step of separating actinium from the product.3. The method of claim 2 , further comprising a reloading step of transferring pure liquefied radium obtained by separating actinium from the product to the reaction space of the chamber.4. The method of claim 2 , further comprising a radon discharge step of discharging radon generated from radium while performing the loading step or the unloading step.5. The method of claim 4 , wherein the radon discharge step comprises condensing radon to discard radon.6. The method of claim 4 , wherein the radon discharge step comprises diluting radon with external air to discharge the diluted radon.7. The method of claim 2 , wherein the loading step comprises moving a preset amount of radium to the reaction space.8. The method of claim 7 , wherein the loading step ...

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Номер записи: 69
31-01-2019 дата публикации

Treatment of unruptured saccular intracranial aneurysms using stereotactic radiosurgery

Номер: US20190030368A1
Автор: LIPANI John D.
Принадлежит:

Methods and devices are disclosed for treating a patient with an unruptured saccular aneurysm that is not associated with an arteriovenous malformation, wherein ionizing radiation is delivered to the brain of a patient through stereotactic radiosurgery. The radiosurgery may be performed with a Gamma Knife, LINAC device such as CyberKnife, or particle-beam device. The treatment impedes a natural progression of the aneurysm towards rupture and may actually obliterate the aneurysm. The treatment plan may be based in part on measured geometric properties of the aneurysm or on physical aneurysm properties such as permeability, wall thickness, wall motion, the presence of macrophages, shear stress, and flow velocities. The methods may be used in conjunction with endovascular coil embolization. 1. A method of treating a patient , wherein the treatment is for an unruptured brain aneurysm that is not associated with an arteriovenous malformation , and wherein a beam of ionizing radiation is delivered to the brain of a patient.2. The method of wherein the treatment impedes a natural progression of the aneurysm towards rupture.3. The method of wherein the aneurysm becomes obliterated following the treatment.4. The method of wherein a recurrence of the aneurysm is prevented or delayed.5. The method of wherein the aneurysm is a saccular aneurysm.6. The method of wherein the aneurysm is associated with an artery of the Circle of Willis.7. The method of wherein the aneurysm is not associated with vasculitis claim 1 , or a vessel to which the aneurysm is attached is not associated with vasculitis.8. The method of wherein the aneurysm did not develop as a consequence of hypertension.9. The method of wherein the aneurysm is not associated with a lenticulostriate vessel.10. The method of claim 1 , wherein the beam of ionizing radiation is produced by a Gamma Knife claim 1 , or by a LINAC device claim 1 , or by a Cyberknife claim 1 , or by a Novalis Tx™ claim 1 , or by a XKnife™ claim ...

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Номер записи: 70
31-01-2019 дата публикации

SYSTEMS AND METHODS FOR PLANNING AND CONTROLLING THE ROTATION OF A MULTILEAF COLLIMATOR FOR ARC THERAPY

Номер: US20190030372A1
Автор: MACDONALD Robert Lee, SYME Alasdair, THOMAS Christopher G.
Принадлежит:

Systems and methods are provided for determining an angular trajectory for dynamically rotating a multileaf collimator during arc therapy. According to various embodiments, a suitable collimator trajectory may be determined based on the reduction or minimization of a residual unblocked area residing between a planning target volume and leaves of the multileaf collimator in the beam's eye view over the set of control points corresponding to an arc therapy plan. Various example methods are provided for determining collimator trajectories based on whitespace reduction, and for providing quantitative measures of whitespace optimization associated with a given trajectory. In some embodiments, the whitespace may be calculated using terms that account for the overlap of a planning target volume with an organ at risk of exposure. 142.-. (canceled)43. A computer-implemented method for determining a collimator trajectory for controlling a multileaf collimator of a radiotherapy device during arc therapy , the method comprising:calculating, for each control point of a set of control points to be employed for generating an arc therapy plan, a plurality of spatial measures corresponding to a set of different collimator angles of the multileaf collimator, wherein each spatial measure is based, at least in part, on a determination of a residual unblocked area residing between a planning target volume and leaves of the multileaf collimator, thereby generating two-dimensional spatial map data characterizing a dependence of spatial measures on control point and collimator angle;processing the spatial map data to determine a selected collimator trajectory that reduces or minimizes a sum of spatial measures accumulated over the set of control points, the selected collimator trajectory associating a single collimator angle with each control point.44. The method according to wherein determining the selected collimator trajectory comprises constraining a change in collimator angle between ...

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Номер записи: 71
30-01-2020 дата публикации

Radioisotope delivery system with multiple detectors to detect gamma and beta emissions

Номер: US20200030522A1
Автор: Adrian Nunn, Andrew SCHIMMOELLER, Brian CHERUNDOLO, Clif MOYERS
Принадлежит: Bracco Diagnostics Inc

A nuclear medicine infusion system (10) may be used to generate and infuse radioactive liquid into a patient undergoing a diagnostic imaging procedure. In some examples, the infusion system includes a frame (30) that carries a radioisotope generator (52) that generates radioactive eluate via elution. The frame may also carry a beta detector (58) and a gamma detector (60). The beta detector can be positioned to measure beta emissions emitted from the radioactive eluate supplied by the generator. The gamma detector can be positioned to measure gamma emissions emitted from a portion of the radioactive eluate to evaluate a safety of the radioactive eluate delivered by the infusion system.

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Номер записи: 72
30-01-2020 дата публикации

SYSTEMS AND TECHNIQUES FOR GENERATING, INFUSING, AND CONTROLLING RADIOISOTOPE DELIVERY

Номер: US20200030523A1
Автор: BOLAS Tarah, CHERUNDOLO Brian, MOYERS Clif, NUNN Adrian, SCHIMMOELLER Andrew
Принадлежит:

An infusion system may include a strontium-rubidium radioisotope generator that generates a radioactive eluate via elution, a beta detector, a gamma detector, and a controller. The beta detector and the gamma detector may be positioned to measure beta emissions and gamma emissions, respectively, emitted from the radioactive eluate. In some examples, the controller is configured to determine an activity of rubidium in the radioactive eluate based on the beta emissions measured by the beta detector and determine an activity of strontium in the radioactive eluate based on the gamma emissions measured by the gamma detector. 1. An infusion system comprising:a frame that carries a beta detector, a gamma detector, and a controller communicatively coupled to the beta detector and the gamma detector,wherein the frame is further configured to receive a strontium-rubidium radioisotope generator that generates a radioactive eluate via elution,the beta detector is positioned to measure beta emissions emitted from the radioactive eluate,the gamma detector is positioned to measure gamma emissions emitted from the radioactive eluate, andthe controller is configured to determine an activity of rubidium in the radioactive eluate based on the beta emissions measured by the beta detector and determine an activity of strontium in the radioactive eluate based on the gamma emissions measured by the gamma detector.2. The infusion system of claim 1 , wherein the gamma detector is positioned to measure the gamma emissions emitted from a static portion of the radioactive eluate.3. The infusion system of claim 1 , wherein the controller is configured to control the infusion system to prevent a patient infusion procedure if the determined activity of strontium exceeds an allowable limit.4. The infusion system of claim 1 , further comprising an infusion tubing line configured to receive the radioactive eluate claim 1 , either directly or indirectly claim 1 , from the strontium-rubidium ...

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Номер записи: 73
30-01-2020 дата публикации

Computer-Implemented Method of Evaluating a Protocol for Radiation Therapy

Номер: US20200030632A1
Автор: Munbodh Reshma
Принадлежит:

A computer-implemented method evaluates a protocol for radiation therapy for a target volume of a patient. The method uses a computer system executing software instructions establishing computer processes. The computer processes receiving and storing data defining the protocol and characterizing the target volume. The computer processes parse the data to extract parameters characterizing the protocol. The computer processes apply the extracted parameters and the target volume to a model that represents relationships among sub-processes and variables pertinent to execution of the protocol in a patient. The computer processes obtain from the model an evaluation of the protocol and providing the evaluation as an output. 1. A computer-implemented method of evaluating a protocol for radiation therapy for a target volume of a patient , the method using a computer system executing software instructions establishing computer processes comprising:receiving and storing data defining the protocol and characterizing the target volume;parsing the data to extract parameters characterizing the protocol;applying the extracted parameters and the target volume to a model, wherein the model represents relationships among sub-processes and variables pertinent to execution of the protocol in a patient;obtaining from the model an evaluation of the protocol and providing the evaluation as an output.2. A method in accordance with claim 1 , wherein the relationships include dependencies claim 1 , constraints claim 1 , and conflicts among the sub-processes and the variables.3. A method in accordance with claim 1 , wherein each of the sub-processes includes at least one of the variables.4. A method in accordance with claim 3 , wherein the sub-processes represent at least three members selected from the group consisting of dose prescription claim 3 , documentation verification claim 3 , planning CT integrity claim 3 , anatomical contours claim 3 , beam configuration claim 3 , dose calculation ...

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Номер записи: 74
02-02-2017 дата публикации

TECHNIQUES FOR ON-DEMAND PRODUCTION OF MEDICAL ISOTOPES SUCH AS MO-99/TC-99M AND RADIOACTIVE IODINE ISOTOPES INCLUDING I-131

Номер: US20170032860A1
Автор: Tsang Francis Yu-Hei
Принадлежит:

A system for radioisotope production uses fast-neutron-caused fission of depleted or naturally occurring uranium targets in an irradiation chamber. Fast fission can be enhanced by having neutrons encountering the target undergo scattering or reflection to increase each neutron's probability of causing fission (n, f) reactions in U-238. The U-238 can be deployed as one or more layers sandwiched between layers of neutron-reflecting material, or as rods surrounded by neutron-reflecting material. The gaseous fission products can be withdrawn from the irradiation chamber on a continuous basis, and the radioactive iodine isotopes (including I-131) extracted. 120-. (canceled)21. A method for producing radioisotopes comprising:introducing non-enriched uranium (“NEU”) material into a an irradiation chamber, the irradiation chamber having one or more walls formed of neutron-reflecting material; at least some neutrons from the irradiating are reflected from at least one of the one or more walls, thereby increasing the path length over which those neutrons are in the NEU material, and', 'the increased path length increases the probability that those neutrons in the NEU material will cause fast fission reactions; and, 'irradiating the NEU material with neutrons having energies above 800 keV to cause fast fission reactions to occur in the NEU material and generate fission products, whereinextracting the fission products from the NEU material.22. The method of wherein one of the fission products extracted comprises at least one of molybdenum-99 (Mo-99) and technetium-99m (Tc-99m).23. The method of wherein one of the fission products extracted comprises at least one of iodine 131 (I-131) and iodine 132 (I-132).24. The method of wherein the NEU material in the irradiation chamber occupies a single spatially contiguous region.25. The method of wherein the NEU material in the irradiation chamber occupies multiple spatially disjoint regions.26. The method of wherein the one or more ...

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Номер записи: 75
04-02-2021 дата публикации

ONLINE ANGLE SELECTION IN ROTATIONAL IMAGING AND TRACKING SYSTEMS

Номер: US20210031052A1
Автор: "OConnell Rob", Jordan Petr, Maurer Calvin, Myronenko Andriy, Schnarr Eric
Принадлежит:

A method of operating a radiation apparatus is described that selects at least a first angle and a second angle from the set of angles for a first rotation of the gantry. The method generates, using an imaging device mounted to the gantry, a first tracking image of the target from the first angle during the first rotation of the gantry. The method generates, using the imaging device, a second tracking image of the target from the second angle during the first rotation of the gantry. The method performs targeting tracking based on the first tracking image and the second tracking image. 1. A method of operating a radiation apparatus , the method comprising:selecting at least a first angle and a second angle from a set of angles for a first rotation of a gantry of a radiation apparatus;generating, using an imaging device mounted to the gantry, a first tracking image of a target from the first angle during the first rotation of the gantry;generating, using the imaging device, a second tracking image of the target from the second angle during the first rotation of the gantry; andperforming target tracking based on the first tracking image and the second tracking image.2. The method of claim 1 , wherein the first angle has a higher tracking quality metric value from the set of angles claim 1 , and wherein the second angle has a separation from the first angle of at least an angle separation threshold.3. The method of claim 1 , further comprising:generating a third tracking image of the target from the first angle during a second rotation of the gantry;performing the target tracking based on the third tracking image;generating a fourth tracking image of the target from the second angle during the second rotation of the gantry; andperforming the target tracking based on the fourth tracking image.4. The method of claim 1 , further comprising:determining that the target tracking based on the second tracking image has failed;continuing a treatment stage of the target;selecting ...

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Номер записи: 76
04-02-2016 дата публикации

DEUTERIUM-DEUTERIUM NEUTRON GENERATORS

Номер: US20160035440A1
Автор: Guo Weijun, Navarro-Sorroche Juan
Принадлежит:

Various embodiments include apparatus and methods of using the apparatus having a neutron generator. The neutron generator can include a neutron generator tube having an inner surface and a cylindrical cavity, a field ionization array cylindrically distributed on the inner surface, and a target rod positioned in the cylindrical cavity. Additional apparatus, systems, and methods are disclosed. 1. An apparatus comprising:a neutron generator tube having an inner surface and a cylindrical cavity;a deuterium source to provide deuterium for deuterium-deuterium fusion reaction of the neutron generator tube;a field ionization array cylindrically distributed on the inner surface; anda target rod positioned in the cylindrical cavity.2. The apparatus of claim 1 , wherein the target rod is positioned along an axis of symmetry of the neutron generator at the center of the cylindrical cavity.3. The apparatus of claim 1 , wherein the field ionization array include a bundle of nano-emitters.4. The apparatus of claim 3 , wherein the nano-emitters are made of tungsten nano-tips or carbon nano-fibers.5. The apparatus of claim 1 , wherein the field ionization array is distributed such that the field ionization array is capable of producing over 50% of monatomic deuterium ions.6. The apparatus of claim 1 , wherein the target rod has material layers disposed on the surface of the target rod.7. The apparatus of claim 6 , wherein the material layers include one or more transition metals.8. The apparatus of claim 7 , wherein the one or more transition metals include one or more of titanium and erbium.9. The apparatus of claim 1 , wherein the neutron generator tube has a turn-on/turn-off time delay lower than 1 micro second.10. The apparatus of claim 1 , wherein the neutron generator tube has a deuterium-deuterium fusion reaction with a neutron production yield higher than 1e7 neutron per second.11. The apparatus of claim 1 , wherein the neutron generator tube is disposed in a housing ...

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Номер записи: 77
01-02-2018 дата публикации

OPTOELECTRONIC NUCLEAR BATTERIES BASED ON RADIONUCLIDE NANOENCAPSULATION AND ORGANIC PHOTODIODES

Номер: US20180033511A1
Автор: BACIAK JAMES EDWARD, JOHNS PAUL M., NINO Juan Claudio
Принадлежит:

Embodiments of the present disclosure relate to compositions including a doped material, batteries including the composition, photovoltaic devices including the battery, and the like. 1. A photovoltaic device , comprising: a battery , wherein the battery includes a composition including a homogeneous mixture of a material doped with radioactive nuclides to form a homogeneous doped material , wherein the homogeneous doped material absorbs a radiation emission from the radioactive nuclides and re-emits a photon , wherein the surface of the battery is wrapped with the photovoltaic cell so that re-emitted photons produced by the doped material are captured by the photovoltaic cell regardless of scattering angle.2. The photovoltaic device of claim 1 , wherein the doped material is transparent to the photon.3. The photovoltaic device of claim 2 , further comprising a transparent material claim 2 , wherein the doped material is disposed within the transparent material claim 2 , wherein the transparent material is transparent to photons claim 2 , wherein the transparent material and the doped material are not the same material.4. The photovoltaic device of claim 3 , wherein the transparent material is selected from: a glass or polymer claim 3 , wherein the glass is formed from the glass formers selected from the group consisting of: B claim 3 , Si claim 3 , Ge claim 3 , Al claim 3 , B claim 3 , P claim 3 , V claim 3 , As claim 3 , Sb claim 3 , Zr claim 3 , and a combination thereof claim 3 , or glasses formed from the intermediate formers selected from the group consisting of: Ti claim 3 , Zn claim 3 , Pb claim 3 , Al claim 3 , Th claim 3 , Be claim 3 , Zr claim 3 , Cd claim 3 , and a combination thereof claim 3 , and wherein the polymer is selected from the group consisting of: low density polyethylene claim 3 , high density polyethylene claim 3 , polypropylene claim 3 , polystyrene claim 3 , polytetrafluoroethylene claim 3 , polyvinylchloride claim 3 , ...

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Номер записи: 78
01-05-2014 дата публикации

COMPACT MICROBEAM RADIATION THERAPY SYSTEMS AND METHODS FOR CANCER TREATMENT AND RESEARCH

Номер: US20140119496A1
Автор: CHANG Sha X., Zhou Otto Z.
Принадлежит: The University of North Carolina at Chapel Hill

The present subject matter relates to compact, non-synchrotron microbeam radiation therapy (MRT) systems and methods for cancer research and treatment based on a carbon nanotube distributed x-ray source array technology. The systems and methods can deliver microscopically discrete x-ray radiation at peak dose rate of 10 Gy per second or higher. The x-ray radiation can be provided by a spatially distributed x-ray source array. The technology can be used, for example and without limitation, for human cancer treatment, for intra-operative radiation therapy, and for pre-clinical cancer research on animal cancer models. 1. A method for image guided microbeam radiation therapy , comprising:imaging a patient to identify a treatment region;positioning the patient in a microbeam irradiator, wherein the irradiator comprises one or a plurality of distributed x-ray source arrays, each with a microbeam collimator and optionally a conformal collimator;aligning the treatment region with a microbeam irradiator position; andirradiating the treatment region with a plurality of substantially parallel microbeams with prescribed beam energy, width, pitch, dose, and peak-to-valley-dose-ratio.2. The method of claim 1 , further comprising synchronizing or gating x-ray microbeam radiation delivery with physiological motions to reduce motion induced microbeam dosimetry blurring.3. The method of claim 1 , further comprising translating the patient or the microbeam irradiator by a predetermined interval after each microbeam irradiation and repeating the process until an entire treatment region is treated by the prescribed beam energy microbeam irradiation.4. The method of claim 1 , wherein the plurality of the x-ray source arrays are configured to deliver an interfaced microbeam radiation pattern in the treatment region to increase valley dose for better tumor control while keeping the valley dose below a threshold value for normal tissue sparing outside the treatment region.5. A compact ...

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Номер записи: 79
05-02-2015 дата публикации

RADIOTHERAPY EQUIPMENT CONTROL DEVICE, RADIOTHERAPY EQUIPMENT CONTROL METHOD, AND PROGRAM EXECUTED BY COMPUTER FOR RADIOTHERAPY EQUIPMENT

Номер: US20150038763A1
Автор: Nakamura Mitsuhiro, SAWADA Akira, Suzuki Yasunobu, Yamada Masahiro
Принадлежит:

A radiotherapy equipment control device acquires reference position information for a specific location at a reference time. Furthermore, representative point reference position information is generated from reference position information for a plurality of markers at the reference time, and relative position information up to the reference position information for the specific location is generated. Moreover, representative point position information at another time is generated from the position information for a plurality of markers in a subject at the other time, which differs from the reference time. In addition, position information for the specific location at the other time is generated from the representative point position information and the relative position information. In this case, representative point reference position information and representative position information are generated on the basis of the position information and reference position information for the plurality of markers, said information having been weighted by weighting factors. 1. A radiotherapy equipment control device that specifies a position of a specific portion from positions of a plurality of markers located in the vicinity of the specific portion within a subject and controls radiotherapy equipment , the radiotherapy equipment control device comprising:a reference position information acquisition unit configured to acquire reference position information representing a position within the body of the subject at a reference time of each of the specific portion and the plurality of markers;a representative point reference position information computation unit configured to generate reference position information representing a position within the body of the subject at the reference time of a representative point of the plurality of markers from the reference position information of the plurality of markers;a relative position information computation unit configured to ...

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Номер записи: 80
05-02-2015 дата публикации

USING DIFFERENT INDICATORS FOR DETERMINING POSITIONAL CHANGES OF A RADIOTHERAPY TARGET

Номер: US20150038765A1
Автор: VILSMEIER Stefan
Принадлежит: BRAINLAB AG

The present invention relates to a method for determining data referred to as target change data which can be used for performing radiotherapy treatment, the target change data describing information on the change of position of a target included in a body of a patient, the method being performed by a computer and comprising the following steps: 1. Method for determining data referred to as target change data which can be used for performing radiotherapy treatment , the target change data describing information on the change of position of a target included in a body of a patient , the method being performed by a computer and comprising the following steps:acquiring determination rule data describing a rule for mapping an indicator change set to the target change data, the indicator change set being a set which comprises more than one element, the elements of the indicator change set respectively representing information on respective changes of positions of indicators, at least two of the indicators respectively indicating a change of position of different body structures referred to as indicator structures,acquiring set data describing an acquired indicator change set; anddetermining the target change data based on the determination rule data and the set data by applying the rule for mapping to the acquired indicator change set;wherein a body structure in which the target is embedded is referred to as target structure and, for determining the target change data, a change of geometry and/or position of the target structure is determined in dependence of the indicator change set by using a model of the target structure.2. The method of claim 1 ,wherein the determined target change data describes at least one of the following:a) the change of position of the target;b) the change of position of the target and the position of the target before the change; andc) the position of the target after the change.3. The method of claim 1 , wherein the information on respective ...

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Номер записи: 81
08-02-2018 дата публикации

RADIATION THERAPY APPARATUS, TREATMENT PLANNING DEVICE, AND METHOD FOR CONTROLLING POSITION OF RADIATION THERAPY APPARATUS

Номер: US20180036557A1
Автор: Kiuchi Takashi, YOSHIMIZU Eiki
Принадлежит: Accuthera Inc.

A radiation therapy apparatus includes a manipulator; a radiation head; a correction unit; and first and second controllers. The manipulator includes an arm movable about n axes (where n is 6 or more). The radiation head, supported by the arm, is configured to emit radiation. The correction unit continuously corrects positional coordinates of the radiation head on the manipulator so that radiation emitted from the radiation head is directed onto a reference point while the radiation head is moved along a predetermined route on a virtual sphere having the reference point as its center. The first controller controls the manipulator so that the radiation head is moved along the route using the corrected positional coordinates. The second controller causes the radiation head to emit radiation toward the reference point as the radiation head passes through radiation emission points on the route. 1. A radiation therapy apparatus , comprising:a manipulator including an arm movable about n axes (where n is a natural number of 6 or more);a radiation head to emit radiation, supported by the arm of the manipulator;a correction unit to continuously correct positional coordinates of the radiation head on the manipulator so that radiation emitted from the radiation head is directed onto a reference point while the radiation head is moved along a predetermined route on a virtual sphere having the reference point as its center;a first controller to control the manipulator so that the radiation head is moved along the route using the corrected positional coordinates; anda second controller to cause the radiation head to emit radiation toward the reference point as the radiation head passes through radiation emission points on the route.2. The radiation therapy apparatus according to claim 1 , further comprising a memory for storing a plurality of correction values corresponding to a plurality of directions for each of the radiation emission points claim 1 ,wherein the first ...

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Номер записи: 82
04-02-2021 дата публикации

GAMMA RAY GENERATOR, GAMMA RAY LITHOGRAPHY SYSTEM AND METHOD OF PERFORMING GAMMA RAY LITHOGRAPHY

Номер: US20210033980A1
Автор: Chou You-Hua, Chuang Kuo-Sheng
Принадлежит: Taiwan Semiconductor Manufacturing Co., Ltd.

One of gamma ray lithography systems includes a gamma ray generator and a wafer stage. The gamma ray generator is configured to generate a substantially uniform gamma ray. The gamma ray generator includes a plurality of gamma ray sources and a rotational carrier. The rotational carrier is configured to hold the gamma ray sources and rotate along a rotational axis. The wafer stage is disposed below the gamma ray generator and configured to secure a wafer. 1. A gamma ray generator , comprising: a main body; and', 'a plurality of holes in the main body; and, 'a rotational carrier, configured to rotate along a rotational axis, comprisinga plurality of gamma ray sources, respectively placed in the holes and radiating gamma rays through bottom openings of the holes.2. The gamma ray generator of claim 1 , wherein a diameter of a top opening opposite to the bottom opening of the hole is not less than a diameter of the gamma ray source claim 1 , and a diameter of the bottom opening is less than a diameter of the gamma ray source.3. The gamma ray generator of claim 1 , wherein the main body is a circular plate claim 1 , and the holes are arranged in a matrix.4. The gamma ray generator of claim 1 , wherein the main body includes a shaft and a plurality of holders connecting to the shaft claim 1 , and the holders have the holes respectively.5. The gamma ray generator of claim 1 , wherein a diameter of the bottom opening of the hole decreases as the hole becomes closer to the rotational axis.6. The gamma ray generator of claim 1 , wherein a separation between the holes increases as the holes becomes closer to the rotational axis.7. The gamma ray generator of claim 1 , wherein the bottom openings of the holes have substantially the same diameter.8. The gamma ray generator of claim 1 , wherein the gamma ray sources are metal radiative ingots claim 1 , metal radiative pills or metal radiative blocks.9. A gamma ray lithography system claim 1 , comprising: a plurality of gamma ray ...

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Номер записи: 83
24-02-2022 дата публикации

AUTOMATED QUALITATIVE DESCRIPTION OF ANATOMICAL CHANGES IN RADIOTHERAPY

Номер: US20220054861A1
Автор: BAL Matthieu Frédéric, BONDAR Maria Luiza, ISOLA Alfonso Agatino
Принадлежит:

A system and a method for monitoring anatomical changes in a subject in radiation therapy are provided, as well as an arrangement for medical imaging and analysis and a computer program product for carrying out the method. For monitoring anatomical changes in a subject in radiation therapy, the following steps are performed. First anatomical image data and subsequent anatomical image data of the subject are received. The first anatomical image data and the subsequent anatomical image data are analyzed. This analysis comprises registering the subsequent anatomical data to the first anatomical data. Changes between the first anatomical image data and the subsequent anatomical image data are identified as change states, and the identified change states are matched to corresponding qualitative descriptions. A monitoring report is provided, which comprises the qualitative descriptions of the identified changes. 1. System for monitoring anatomical changes in a subject in radiation therapy , the system comprising:an analysis unit, comprising an input configured to receive first anatomical image data and subsequent anatomical image data of the subject, which analysis unit is at least configured to register the subsequent anatomical data to the first anatomical data;a change state identification unit configured to identify changes between the first anatomical image data and the subsequent anatomical image data as change states;a qualitative translator configured to match the identified change states to corresponding qualitative descriptions;a reporting unit configured to provide a monitoring report comprising qualitative descriptions of the identified change states.2. The system according to claim 1 , wherein the change state identification unit comprises at least one qualitative spatial reasoning algorithm claim 1 , which qualitative spatial reasoning algorithm is preferably an RCC-8 calculus algorithm and/or a Cardinal spatial reasoning algorithm.3. The system according to ...

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Номер записи: 84
24-02-2022 дата публикации

MEDICAL IMAGE PROCESSING DEVICE, STORAGE MEDIUM, MEDICAL DEVICE, AND TREATMENT SYSTEM

Номер: US20220054862A1
Автор: Hirai Ryusuke, MORI Shinichiro, OKAYA Keiko, SAKATA Yukinobu, Tanizawa Akiyuki
Принадлежит:

A medical image processing device of an embodiment includes a first image acquirer, a second image acquirer, a generator, and a calculator. The first image acquirer acquires a first fluoroscopic image of a patient. The second image acquirer acquires a second fluoroscopic image according to radiation with which the patient is irradiated at a time point different from a time point of acquisition of the first fluoroscopic image from a photography device that detects radiation with a detector and performs an imaging process. The generator generates a reconstructed image obtained by reproducing the second fluoroscopic image from the first fluoroscopic image virtually arranged in a three-dimensional space on the basis of an installation position of the detector in the three-dimensional space. The calculator obtains a suitable position on the first fluoroscopic image in the three-dimensional space on the basis of a degree of similarity between the second fluoroscopic image and the reconstructed image. The generator generates the reconstructed image which is for use in the calculator and has a range larger than a range corresponding to the second fluoroscopic image. 1. A medical image processing device comprising:a first image acquirer configured to acquire a first fluoroscopic image of a patient;a second image acquirer configured to acquire a second fluoroscopic image according to radiation with which the patient is irradiated at a time point different from a time point of acquisition of the first fluoroscopic image from a photography device that detects radiated radiation with a detector and performs an imaging process;a generator configured to generate a reconstructed image obtained by reproducing the second fluoroscopic image from the first fluoroscopic image virtually arranged in a three-dimensional space on the basis of an installation position of the detector in the three-dimensional space; anda calculator configured to obtain a suitable position on the first ...

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Номер записи: 85
30-01-2020 дата публикации

METHOD AND SYSTEM FOR SURFACE MODIFICATION OF SUBSTRATE FOR ION BEAM TARGET

Номер: US20200037430A1
Автор: Gillespie Joseph, JR. William H., Lambert Mark, Park, Sakase Takao, Smick Noah
Принадлежит: Neutron Therapeutics, Inc.

Design and making methods of a neutrons generating target are described. In some embodiments, a surface of a target substrate can be modified to form one or more surface features. In some embodiments, a neutron source layer can be disposed on the surface of the target substrate. In some embodiments, the neutron source layer and the target substrate can be heated to an elevated temperature to form a bond between the two. In some embodiments, the surface modification of the target substrate can reduce blistering and material exfoliation in the target. The target can be used in boron neutron capture therapy. 1. A method for making a neutron generating target , the method comprising:disposing a neutron source layer on a surface of a target substrate; andmodifying a surface of the neutron source layer to form one or more surface features.2. The method of claim 1 , wherein the modifying a surface of the neutron source layer comprises a material removal process or a material addition process.3. The method of claim 2 , wherein the material removal process comprises abrasive blasting claim 2 , etching claim 2 , or polishing.4. The method of claim 2 , wherein the material addition process comprises vacuum deposition claim 2 , plating claim 2 , or printing.5. The method of claim 1 , wherein the disposing a neutron source layer on a surface of the target substrate comprises pressing the neutron source layer on the surface of the target substrate claim 1 , or depositing the neutron source layer on the surface of the target substrate by evaporation.6. The method of claim 1 , further comprising heating the neutron source layer and the target substrate to an elevated temperature for a duration of time to form a bond between the neutron source layer and the target substrate.7. The method of claim 6 , wherein the elevated temperature is between about 100 degrees Celsius and about 500 degrees Celsius.8. The method of claim 6 , wherein the duration of time is between about 0.1 hours ...

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Номер записи: 86
07-02-2019 дата публикации

DETERMINING AN IRRADIATION REGION FOR RADIOTHERAPY BASED ON MODEL PATIENT DATA AND PATIENT IMAGE DATA

Номер: US20190038920A1
Автор: VILSMEIER Stefan
Принадлежит:

The invention relates to a method of determining a radiotherapy treatment plan for radiotherapy treatment of a treatment body part of a patient's body. The method can include acquiring treatment target position data comprising treatment target position information describing the position of a treatment target to be treated by radiotherapy in the treatment body part. Statistic model target region position data is acquired, which describes the position of a model target region in a model body part corresponding to the treatment body part. Based on the treatment target data and the statistic model target region position data, irradiation region position data is determined that describes the position of an irradiation region to be treated by irradiation with treatment radiation in the treatment body part. 1. A method of determining a radiotherapy treatment plan for radiotherapy treatment of a treatment body part of a patient's body , the method being executed by a computer and comprising the following steps:a) acquiring treatment body part position data indicating a position of the treatment body part and treatment target position data comprising treatment target position information describing the position of a treatment target to be treated by radiotherapy in the treatment body part; wherein the statistic model target region position data has been generated based on model target position data comprising model target position information describing the positions of model treatment targets in a plurality of model bodies which display a medical condition corresponding to the medical condition to be treated,', 'wherein the statistic model target region position data comprises spatial target region cluster data comprising spatial target region cluster information describing at least one spatial cluster that defines a geometric concentration of the model treatment targets in at least one specific anatomic region in all of the plurality of model bodies, and', 'wherein the ...

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Номер записи: 87
09-02-2017 дата публикации

NEUTRON GENERATION USING PYROELECTRIC CRYSTALS

Номер: US20170040075A1
Автор: Falabella Steven, Guethlein Gary, Harris John, MEYER Glenn A., Morse Jeff, Rusnak Brian, Sampayan Stephen, Spadaccini Christopher M., Tang Vincent, WANG LI-FANG
Принадлежит:

According to one embodiment, a method for producing a directed neutron beam includes producing a voltage of negative polarity of at least −100 keV on a surface of a deuterated or tritiated target in response to a temperature change of a pyroelectric crystal of less than about 40° C., the pyroelectric crystal having the deuterated or tritiated target coupled thereto, pulsing a deuterium ion source to produce a deuterium ion beam, accelerating the deuterium ion beam to the deuterated or tritiated target to produce a neutron beam, and directing the ion beam onto the deuterated or tritiated target to make neutrons using at least one of a voltage of the pyroelectric crystal, and a high gradient insulator (HGI) surrounding the pyroelectric crystal. The directionality of the neutron beam is controlled by changing the accelerating voltage of the system. Other methods are presented as well. 1. A method for producing a directed neutron beam , the method comprising:producing a voltage of negative polarity of at least −100 keV on a surface of a deuterated or tritiated target in response to a temperature change of a pyroelectric crystal of less than about 40° C., the pyroelectric crystal having the deuterated or tritiated target coupled thereto;pulsing a deuterium ion source to produce a deuterium ion beam;accelerating the deuterium ion beam to the deuterated or tritiated target to produce a neutron beam; anddirecting the ion beam onto the deuterated or tritiated target to make neutrons using at least one of a voltage of the pyroelectric crystal, and a high gradient insulator (HGI) surrounding the pyroelectric crystal,wherein the directionality of the neutron beam is controlled by changing an accelerating voltage of the method.2. The method of claim 1 , wherein the pyroelectric crystal is formed of a material selected from a group consisting of: lithium tantalite claim 1 , lithium niobate claim 1 , and barium strontiate.3. The method of claim 1 , further comprising a thermal ...

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Номер записи: 88
06-02-2020 дата публикации

IMAGE-GUIDED RADIATION THERAPY

Номер: US20200038683A1
Автор: BUERGER Christian, Nielsen Tim, Schadewaldt Nicole
Принадлежит:

For delivering an image-guided radiation therapy treatment to a moving structure included in a region of a patient body a series of first images of the region of the patient body in different phases of a motion of the structure is acquired in accordance with a first imaging mode. The series of first images is associated with a series of second images of the patient body in essentially the same phases of the motion of the target structure, the second images being acquired in a second imaging mode. During the treatment, a third image is acquired using the second imaging mode during the radiation therapy treatment and a continuation of the radiation therapy treatment is planned on the basis of data relating to one of the first images selected on the basis of a comparison between the third image and the second images associated with the first images. 2. The treatment system as defined in claim 1 , wherein the second imaging mode is selected such that it allows for a faster image acquisition compared with the first imaging mode.3. The treatment system as defined in claim 1 , wherein the first images are three-dimensional images and wherein the second and third images are three-dimensional claim 1 , two-dimensional or one-dimensional images.4. The treatment system as defined in claim 1 , wherein the evaluation unit is configured to identify a motion phase associated with at least one second image that best matches the third image in accordance with a predefined criterion and to select the first image associated to the identified motion phase as the first image on the basis of which the continuation of the radiation therapy treatment is planned.5. The treatment system as defined in claim 1 , wherein evaluation unit is configured to plan the continuation of the treatment on the basis of an estimated accumulated radiation dose delivered to the structure in the radiation therapy treatment claim 1 , the accumulated dose being determined based on a deformation vector field for ...

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Номер записи: 89
06-02-2020 дата публикации

IMAGERS IN RADIATION THERAPY ENVIRONMENT

Номер: US20200038687A1
Автор: Amstutz Martin, MORF Daniel
Принадлежит:

An imager includes: an array of imager elements configured to generate image signals based on radiation received by the imager; and circuit configured to perform readout of image signals, wherein the circuit is configured to be radiation hard. An imager includes: an array of imager elements configured to generate image signals based on the radiation received by the imager; and readout and control circuit coupled to the array of imager elements, wherein the readout and control circuit is configured to perform signal readout in synchronization with an operation of a treatment beam source. 1. An imager comprising:an array of imager elements configured to generate image signals based on radiation received by the imager; andcircuit configured to perform readout of image signals, wherein the circuit is configured to be radiation hard.2. The imager of claim 1 , wherein the circuit is configured to withstand at least 100 kRad of radiation.3. The imager of claim 1 , wherein the circuit is configured to withstand at least 500 kRad of radiation.4. The imager of claim 1 , wherein the imager is configured to remain fully functional even after the imager has been exposed to radiation resulting from up to 18 MV treatment beam with parameters of 100 kRad and 600 Mu/min.5. The imager of claim 1 , wherein the circuit comprises readout and control circuit coupled to the array of imager elements claim 1 , wherein the readout and control circuit is radiation hard.6. The imager of claim 1 , wherein the circuit comprises a gate driver claim 1 , and wherein the gate driver is radiation hard.7. The imager of claim 1 , wherein the circuit of the imager comprises a commercial component that is not marketed as radiation hard claim 1 , but has been tested as meeting certain radiation hardness requirement.8. The imager of claim 1 , wherein the circuit of the imager comprise a commercial component that is marketed as radiation hard.9. The imager of claim 1 , wherein the circuit of the imager has ...

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Номер записи: 90
18-02-2021 дата публикации

RADIATION TREATMENT PARAMETERS FOR TARGET REGION TUMOUR

Номер: US20210046328A1
Автор: Berlinger Kajetan, STEAD Michael
Принадлежит:

Disclosed is a computer-implemented method which encompasses comparing the requirements for radiation therapy imposed by a patient's individual condition to the capabilities and requirements of different types of treatment machines to determine a suitable radiation treatment strategy including an identification of the treatment machine which shall be used and a treatment plan. Furthermore, a treatment plan is generated by simulating the envisaged radiation treatment. The type of treatment machine associated with a predetermined value for the sum of weights for all fields assigned to that treatment machine is determined as the treatment machine for treating the patient, and corresponding information is output detailing the treatment specifics such as radiation treatment parameters specifically suited for the patient target region tumor thereby reducing radiation exposure, efficient use of the machine and appropriate gating and tracking modes. 1. A computer-implemented method of determining a radiation treatment procedure for radiation treatment of a target region subject to vital movement , comprising:acquiring medical patient image data describing a time-dependent series of digital patient images of the target region, wherein the target region is included in an anatomical body part of a patient;determining, based on the medical patient image data, amplitude data describing an amplitude of the vital movement of the target region;acquiring availability data describing the availability of breathing curve data describing an external breathing curve of the patient;acquiring treatment machine capability data describing the imaging and beam control capabilities as well as the achievable dose rate of a plurality of radiation treatment machines;acquiring machine control data describing a treatment time associated with a size of the target region and different modes of imaging and beam activation by different types of treatment machines for conducting radiation treatment and ...

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Номер записи: 91
18-02-2016 дата публикации

Real-time, on-line and offline treatment dose tracking and feedback process for volumetric image guided adaptive radiotherapy

Номер: US20160045768A1
Автор: Martinez Alvaro, Yan Di
Принадлежит:

A method of treating an object with radiation that includes generating volumetric image data of an area of interest of an object and emitting a therapeutic radiation beam towards the area of interest of the object in accordance with a reference plan. The method further includes evaluating the volumetric image data and at least one parameter of the therapeutic radiation beam to provide a real-time, on-line or off-line evaluation and on-line or off-line modification of the reference plan. 168-. (canceled)69. A method of forming a portal image , the method comprising: forming a two-dimensional image of an object of interest;superimposing an image of a collimator element on said two-dimensional image, wherein said image represents the position of said collimator element when a radiation therapy beam is to be directed towards said object of interest.70. The method of claim 69 , wherein said two-dimensional image is formed from a volumetric image.71. The method of claim 69 , further comprising determining said position of said collimator element when said radiation therapy beam is to be directed towards said object of interest.72. The method of claim 69 , wherein said object of interest substantially changes position and shape during a therapy session and said two-dimensional image is a fluoroscopic image.73. The method of claim 69 , wherein said object of interest does not substantially change its position and shape during a therapy session and. said two-dimensional image is a radiographic image. Applicants claim, under 35 U.S.C. §119(e), the benefit of priority of 1) the filing date of May 25, 2006, of U.S. Provisional Patent Application Ser. No. 60/808,343, filed on the aforementioned date and 2) the filing date of Jan. 18, 2007, of U.S. Provisional Patent Application Ser. No. 60/881,092, filed on the aforementioned date, the entire contents of each of which are incorporated herein by reference.1. Field of the InventionThe present invention relates generally to image ...

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Номер записи: 92
16-02-2017 дата публикации

MOVING-BODY TRACKING DEVICE FOR RADIATION THERAPY, IRRADIATION REGION DETERMINING DEVICE FOR RADIATION THERAPY, AND RADIATION THERAPY DEVICE

Номер: US20170043184A1
Автор: MORI Shinichiro, TORIGOE Yui, YAMAGISHI Yoshiyuki
Принадлежит:

A radiation therapy apparatus includes a radiation irradiation unit , an X-ray imaging unit , a CT imaging device , a treatment planning device , and a controller . The controller includes a CT image deformation amount calculation unit , a shape calculation unit , an irradiation region determining unit , an X-ray image deformation amount calculation unit , a position calculation unit , a template matching unit , a comparison unit , a correction unit , and an image processing unit , and by comparing the positions of a treatment target locus in respective breathing phases and the positions of the treatment target locus in corresponding ones of the respective breathing phases identified by the template matching unit , identifies the error values between the positions and the positions identified by the template matching unit for each of parameters. 1. A moving body tracking device for radiation therapy , wherein said moving body tracking device is used for radiation therapy to treat a patient by irradiating said patient with a treatment beam , comprising:an X-ray image information acquisition circuit that acquires a position of a treatment target locus in a reference breathing phase and three-dimensional X-ray image data consisting of a group of two-dimensional X-ray image data of a region including the treatment target locus in multiple successive breathing phases from a storage device;an X-ray image deformation amount calculation circuit that calculates a deformation amount of a two-dimensional X-ray image including the treatment target locus between different breathing phases by performing image registration on the three-dimensional X-ray image data acquired from said storage device;a position calculation circuit that calculates positions of the treatment target locus in the respective breathing phases on a basis of the position of the treatment target locus in the benchmark reference breathing phase acquired from said storage device and the deformation amount of ...

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Номер записи: 93
16-02-2017 дата публикации

DYNAMIC ENERGY CONTROL OF A CHARGED PARTICLE IMAGING/TREATMENT APPARATUS AND METHOD OF USE THEREOF

Номер: US20170043187A1
Автор: Amato Mark R., Lee W. Davis, Penfold Scott
Принадлежит:

The invention comprises a beam adjustment method and apparatus used to perform energy adjustments on circulating charged particles in a synchrotron previously accelerated to a starting energy with a traditional accelerator of the synchrotron. The beam adjustment system uses a radio-frequency modulated potential difference applied along a longitudinal path of the circulating charged particles to accelerate or decelerate the circulating charged particles. Optionally, the beam adjustment system phase shifts the applied radio-frequency field to accelerate or decelerate the circulating charged particles while tightening spatial distribution of a grouped bunch of the circulating charged particles. Optionally, the beam adjustment system simultaneously radially focuses the circulating charged particles using two or more gaps with focusing and/or defocusing edges. The beam adjustment system facilitates treating multiple layers or depths of the tumor without hysteresis and/or between the repeating slow steps of reloading the synchrotron. 1. A method for treating a tumor of a patient with positively charged particles , comprising the steps of:loading a synchrotron of a charged particle cancer therapy system with the positively charged particles using a loading system;using an accelerator of said synchrotron to accelerate the positively charged particles in a circulation beam path of said synchrotron;removing a first set of the positively charged particles, from said synchrotron, at a first energy using a beam extraction system;treating the tumor using the first set of positively charged particles; a first gap axially crossing said circulation beam path; and', 'a first radio-frequency controller;, 'providing a beam energy adjustment system, comprisingapplying a potential difference across the first gap, using said first radio-frequency controller, at an applied radio-frequency using said beam energy adjustment system;timing the applied radio-frequency and the potential ...

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Номер записи: 94
16-02-2017 дата публикации

Radiosurgical Neuromodulation Devices, Systems, and Methods for Treatment of Behavioral Disorders by External Application of Ionizing Radiation

Номер: US20170043188A1
Автор: ADLER John R., Borchers, III Doyle John, Schneider M. Bret
Принадлежит:

Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased. 1. A method of treating a psychiatric disorder or a neurological disorder of a patient , the psychiatric disorder or the neurological disorder of the patient associated with a level of neuronal activity in a neural circuit within a brain of the patient , the method comprising:transmitting a cellularly sub-lethal quantity of ionizing radiation from outside the patient into a target comprising at least a portion of the amygdala within the brain of the patient so as to alter the level of neuronal activity in the neural circuit such that the psychiatric disorder or the neurological disorder is mitigated, wherein the radiation is transmitted from a radiation source machine outside the patient, through a skull of the patient and into the brain of the patient along a plurality of beam paths directed from varying directions so as to intersect with the target.2. The method of claim 1 , wherein the psychiatric disorder or the neurological disorder is obsessive-compulsive disorder.3. The method of claim 1 , wherein the psychiatric disorder or the ...

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Номер записи: 95
15-02-2018 дата публикации

BASE FOR NOVEL ACCELERATOR THERAPY DEVICE AND NOVEL ACCELERATOR THERAPY DEVICE

Номер: US20180043185A1
Автор: YAO Jonathan Yi
Принадлежит:

The invention discloses a base for a novel accelerator therapy device. A boat-shaped rocker arm is creatively utilized to drive a main frame to rotate around an X axis, and meanwhile an accelerator simultaneously follows the main frame to rotate around a Z axis, so that the accelerator runs on a spherical surface and irradiates an isocentric lesion in any direction of a three-dimensional spherical space; the center of gravity of the boat-shaped rocker arm is low, the boat-shaped rocker arm bears weight on the curved surface, and a rotating shaft and an upright post for bearing the weight of the main frame and the weight of the accelerator in the prior art are removed, so that the base is high in stability, safe, reliable and low in requirement for transmission equipment and easily realizes industrialized application. 1. A base for a novel accelerator therapy device , which is used for the accelerator therapy device comprising a therapy control device , a main frame and an accelerator , wherein the accelerator is installed on the main frame , the therapy control device is used for controlling the accelerator and the main frame , and the base for the novel accelerator therapy device comprises:a boat-shaped rocker arm, wherein the main frame is installed at the upper part of the boat-shaped rocker arm, the lower part of the boat-shaped rocker arm is an arc curved surface, and the boat-shaped rocker aim can rotate around a circle center corresponding to the arc curved surface; the main frame can rotate around an axis, the accelerator follows the main frame to rotate, and the central axis of rays emitted by the accelerator is perpendicular to the axis and is intersected with the axis at a point, i.e., an isocenter; the rotating plane of the boat-shaped rocker arm is perpendicular to that of the main frame; the circle center is superposed with the isocenter; the accelerator runs on a spherical surface under the co-action of rotation of the boat-shaped rocker arm and ...

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Номер записи: 96
07-02-2019 дата публикации

METHOD FOR PREPARING RADIOACTIVE SUBSTANCE THROUGH MUON IRRADIATION, AND SUBSTANCE PREPARED USING SAID METHOD

Номер: US20190043631A1
Автор: MATSUZAKI Teiichiro, SAKURAI Hiroyoshi
Принадлежит:

In order to prepare a useful radioactive substance from radionuclides included in high-level radioactive waste and the like, an embodiment of the present invention provides a method for preparing a radioactive substance including a muon irradiation step for obtaining a first radionuclide by causing negative muons to be incident onto a radioactive target nuclide and triggering a nuclear muon capture reaction. The prepared radioactive substance includes at least one of the first radionuclide and a second radionuclide that is at least one type of a descendant nuclide obtained from the first radionuclide through radioactive decay. An embodiment of the present invention also provides the radioactive substance. 1. A method for producing a radioactive substance comprising a muon irradiation step for obtaining a first radionuclide through a muon nuclear capture reaction by irradiating a target nuclide which is a radionuclide with negative muons ,wherein the radioactive substance to be produced comprises at least one of the first radionuclide and a second radionuclide, the second radionuclide being a descendant nuclide obtained from the first radionuclide via radioactive decay.2. The method for producing a radioactive substance according to further comprising preparing a target raw material containing the target nuclide to be irradiated with negative muon prior to the muon irradiation step claim 1 ,wherein the target nuclide in the target raw material is any of radionuclides in long-lived fission products (LLFPs) contained in a spent nuclear fuel or a substance separated from a spent nuclear fuel.3. The method for producing a radioactive substance according to claim 2 , wherein the target nuclide is Tc claim 2 , the first radionuclide is Mo claim 2 , and the second radionuclide is Tc.4. The method for producing a radioactive substance according to claim 1 ,{'sup': 99', '99', '99m, 'wherein the target nuclide is Tc, the first radionuclide is Mo, and the second radionuclide is ...

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Номер записи: 97
06-02-2020 дата публикации

CLOSED EVAPORATION SYSTEM

Номер: US20200043620A1
Автор: Franci Xavier, LANGE Audrey, LIGNON Steve
Принадлежит:

The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species. 121-. (canceled)22. A method for the synthesis of a radiolabelled compound wherein said method comprises:(i) radiolabelling a protected precursor compound in a fixed volume container to obtain a protected radiolabelled compound;(ii) deprotecting the protected radiolabelled compound obtained from radiolabelling step (i) to obtain said radiolabelled compound wherein said deprotection is effected using a hydrolysis medium;(iii) connecting the fixed volume container via a 3-way valve to an expandable volume; and,(iv) heating the radioactive fluid in the fixed volume container above its boiling point to reach the equilibrium gas/liquid phase causing said liquid to vaporise and move into the expandable volume where it condenses due to the drop in temperature to form a volume of radioactive fluid in the expandable volume.23. The method as defined in wherein said fixed volume container is a reaction vessel.24. The system as defined in wherein said expandable volume is a syringe.25. The method as defined in wherein said radiolabelled compound is a radiopharmaceutical.26. The method as defined in wherein said radiopharmaceutical is a diagnostic radiopharmaceutical.27. The method as defined in wherein said ...

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Номер записи: 98
06-02-2020 дата публикации

Radioactive fine particle manufacturing system, and radioactive fine particle manufacturing method

Номер: US20200043622A1
Автор: Shinji TOKONAMI
Принадлежит: Hirosaki University NUC

A radioactive fine particle manufacturing system to manufacture physically stable radioactive fine particles without using large-scale equipment, which enable performance evaluation of a radioactivity measuring instrument employing a novel physical indicator, with which a method for controlling radioactivity concentration by means of the humidity of air is presented in a specific manner, and with which it is possible to implement performance evaluation of the overall radioactivity measuring instrument. The radioactive fine particle manufacturing system uses a configuration provided with a radioactive gas generating system, a specific particle-sized aerosol generating system and a mixing chamber, to manufacture radioactive fine particles employing natural radioactive nuclides. 220 Rn is employed to manufacture radioactive fine particles using physically stable progeny nuclides. In the mixing chamber, the progeny nuclides are caused to attach only to an aerosol having a specific particle size, to generate radioactive fine particles having a specific particle size.

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Номер записи: 99
18-02-2021 дата публикации

NEW METHOD AND APPARATUS FOR THE PRODUCTION OF HIGH PURITY RADIONUCLIDES

Номер: US20210050126A1
Автор: Andreoletti Gilbert, Bourdet Patrick, Dureau Rémy, Maquaire Patrick, Torgue Julien
Принадлежит:

An apparatus is for the automated production of a daughter radionuclide from a parent radionuclide using a generator comprising a solid medium onto which the parent nuclide is fixed and whereby the daughter nuclide is formed by radioactive decay of the parent nuclide. The apparatus includes a fluid circuit including a chromatography column having a head port and a tail port, at least one connection port for connecting the generator to the fluid circuit, at least one inlet port for connecting fluid sources to the fluid circuit and at least one valve controlled by an electronic control unit for selectively connecting the chromatography column, the connection port and the at least one inlet port in various configurations. The various configurations include a first elution configuration for circulating an A′ solution exiting the generator and containing the daughter radionuclide, through the chromatography column from the head port to the tail port for loading the chromatography column with the daughter radionuclide; a first washing configuration for circulating an A washing solution from a solution inlet through the chromatography column from the head port to the tail port; and a second washing configuration for circulating an A′ washing solution from a solution inlet through the chromatography column from the tail port to the head port. 1. An apparatus for the automated production of a daughter radionuclide from a parent radionuclide using a generator comprising a solid medium onto which the parent nuclide is fixed and whereby the daughter nuclide is formed by radioactive decay of the parent nuclide , the apparatus comprising a fluid circuit comprising:a chromatography column having a head port and a tail port;at least one connection port for connecting the generator to the fluid circuit;at least one inlet port for connecting fluid sources to the fluid circuit; and [{'b': '1', 'a first elution configuration for circulating an A′ solution exiting the generator and ...

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Номер записи: 100