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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 5928. Отображено 100.
21-06-2017 дата публикации

Варочная панель

Номер: RU0000171920U1
Автор: Сергей Геннадьевич Будаев
Принадлежит: Сергей Геннадьевич Будаев

Полезная модель относится к теплоэнергетике и кулинарии. Задача создания полезной модели: обеспечение точности дозировки рецептуры блюд. Техническим результатом заявленного технического решения является обеспечение точности дозировки рецептуры блюд. Решение указанных задач достигнуто в варочной панели, содержащей верхнюю крышку и, по меньшей мере, один нагреватель, и, по меньшей мере, один датчик веса, связанный с нагревателем, и цифровой индикатор веса, тем, что она содержит индикатор калорийности продукта. В качестве нагревателя может быть применен электрический нагреватель. В качестве нагревателя может быть применена газовая форсунка. В качестве нагревателя может быть применен оптический нагреватель. В качестве нагревателя может быть применен индукционный нагреватель. Варочная панель может содержать индикатор калорийности продукта. 4 з.п. ф-лы, 8 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 171 920 U1 (51) МПК F24B 1/20 (2006.01) F24C 7/08 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ФОРМУЛА ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21)(22) Заявка: 2017100697, 10.01.2017 (24) Дата начала отсчета срока действия патента: 10.01.2017 (72) Автор(ы): Будаев Сергей Геннадьевич (RU) (73) Патентообладатель(и): Будаев Сергей Геннадьевич (RU) 21.06.2017 (56) Список документов, цитированных в отчете о поиске: EP 1275904 A2, 15.01.2003. RU Приоритет(ы): (22) Дата подачи заявки: 10.01.2017 (45) Опубликовано: 21.06.2017 Бюл. № 18 Адрес для переписки: 443112, г. Самара, ул. Крайняя, 18, кв. 17, Болотину Николаю Борисовичу 1 7 1 9 2 0 R U (57) Формула полезной модели 1. Варочная панель, содержащая, верхнюю крышку, по меньшей мере, один нагреватель, и, по меньшей мере, один датчик веса, связанный с нагревателем и цифровой индикатор веса, отличающаяся тем, что она содержит индикатор калорийности продукта. 2. Варочная панель по п. 1, отличающаяся тем, что в качестве нагревателя применен электрический нагреватель. 3. Варочная панель по п. 1, отличающаяся ...

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Номер записи: 1
28-03-2013 дата публикации

DEVICE COMPRISING A CONDUCTIVE SURFACE AND A CONDUCTIVE POLYMER FOR ADHESION OF CELLS AND TISSUE

Номер: US20130078701A1
Автор: Berggren Magnus, Jager Edwin, Karlsson Roger, Konradsson Peter, Persson Kristin, Richter-Dahlfors Agneta, Svennersten Karl
Принадлежит: OBOE IPR AB

The present disclosure relates to a device comprising a conductive substrate surface (), at least one layer of a conductive polymer () deposited on the surface (), a first electrolyte () arranged in contact with the conductive polymer layer, and a counter electrode (), arranged in contact with the first electrolyte (), such that a potential difference can be applied between the conductive substrate () and the counter electrode (). 1. A device comprising:a conductive substrate surface,at least one layer of a conductive polymer,a first electrolyte arranged in contact with the conductive polymer layer, and the conductive polymer, in a first state, before applying the potential difference, exhibits a first adhesive capacity, wherein the conductive polymer layer is substantially attached to the conductive substrate surface; and', 'the conductive polymer, in a second state, subsequent to application of the potential difference, exhibits a second adhesive capacity, whereby at least a portion of the conductive polymer layer is substantially released from the conductive substrate surface., 'a counter electrode, arranged in contact with the first electrolyte, such that a potential difference can be applied between the conductive substrate and the counter electrode, wherein'}2. The device as claimed in claim 1 , wherein a rate of release is controllable by a magnitude of the potential difference applied.3. The device as claimed in claim 1 , wherein the device further comprises an additional material layer claim 1 , arranged between the conductive polymer layer and the first electrolyte.4. The device as claimed in claim 3 , wherein the additional material comprises cells or tissue.5. The device as claimed in claim 4 , wherein the device further comprises a second electrolyte arranged between the conductive polymer layer and the additional material layer.6. The device as claimed in claim 5 , wherein the second electrolyte is a solid electrolyte layer.7. (canceled)8. (canceled)9. ...

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Номер записи: 2
28-03-2013 дата публикации

DEVICE FOR VIRAL INACTIVATION OF LIQUID MEDIA

Номер: US20130078702A1
Автор: Dhanasekharan Muthukumar
Принадлежит: Genzyme Corporation

An apparatus () capable of viral inactivation of liquid media includes at least one coaxial cylinder () constructed of an outer cylinder () and an inner cylinder (), a liquid media inlet (), at least one emitter of type C ultraviolet radiation (), and a liquid media outlet (). The inner cylinder has an outer diameter adapted to form a gap () between the outer diameter of the inner cylinder and the inner diameter of the outer cylinder. The media flows in a substantially cyclonic flow path along the gap. The at least one emitter of type C ultraviolet radiation is placed inside the inner cylinder. The outlet is connected to the outer cylinder at, or proximal to, an end of the outer cylinder opposite the inlet. 1. An apparatus capable of viral inactivation of cell culture media comprising: i) an outer cylinder having a length, an inner diameter, and an outer diameter;', 'ii) an inner cylinder coaxial with the outer cylinder, having a length substantially equal to the length of the outer cylinder and having an outer diameter adapted to form a gap between the outer diameter of the inner cylinder and the inner diameter of the outer cylinder through which the cell culture media flows in a substantially cyclonic flow path along the gap;, 'a) at least one coaxial cylinder comprisingb) a cell culture media inlet connected to the outer cylinder proximal to an end of the outer cylinder and configured to flow the cell culture media along the substantially cyclonic flow path along the gap;c) at least one emitter of type C ultraviolet radiation placed inside the inner cylinder so as to emit the type C ultraviolet radiation towards the cell culture media to be treated with the type C ultraviolet radiation and thereby inactivate viruses in the cell culture media; andd) a cell culture media outlet connected to the outer cylinder proximal to an end of the outer cylinder opposite the inlet.2. The apparatus of claim 1 , wherein the cell culture media flows along the gap at a flow rate in ...

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Номер записи: 3
11-04-2013 дата публикации

Alternating Electric Current Directs, Enhances, and Accelerates Mesenchymal Stem Cell Differentiation Into Either Osteoblasts or Chondrocytes But Not Adipocytes

Номер: US20130089908A1
Автор: Bizios Rena, Creecy Courtney M.
Принадлежит:

A method for directing, enhancing, and accelerating mesenchymal stem cell functions using alternating electric current. Mesenchymal stem cells are preferentially directed to either osteoblast or chondrocyte lineages, but not to the adipocyte lineage. when exposed to alternating electric current. 1. A method for directing , enhancing , and accelerating mesenchymal stem cell functions , comprising the steps of:culturing mesenchymal stem cells within a three-dimensional matrix or scaffold:exposing mesenchy mal stem cells to alternating electric current.2. The method of claim 1 , wherein the mesenchymal stemcell function is differentiation.3. The method of claim 2 , wherein the mesenchymal ate cells are differentiated to either osteoblast or chondrocyte lineages.4. The method of wherein the three-dimensional matrix or scaffold is current-conducting.5. The method of claim 1 , wherein the three-dimensional matrix is a collagen hydrogel.6. The method of claim 1 , wherein the alternating electric current is a current level pertinent to directing claim 1 , enhancing claim 1 , and accelerating the desired mesenchymal stem cell function.7. The method of claim 1 , wherein the alternating electric current is a current in the range from 10 μA to 40 μA.8. The method of claim 1 , wherein the alternating electric current is a frequency pertinent to directing claim 1 , enhancing. and accelerating the target mesenchymal stem cell function.9. The method of claim 1 , wherein the alternating electric current is a frequency of 10 Hz.10. The method of claim 1 , wherein the alternating electric current is a waveform pertinent to directing claim 1 , enhancing claim 1 , and accelerating the target mesenchymal stem cell function.11. The method of claim 1 , wherein the alternating electric current is of a sinusoidal waveform.12. The method of claim 1 , wherein the alternating electric current is for either a continuous or intermittent pattern and a duration of application pertinent to directing ...

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Номер записи: 4
09-05-2013 дата публикации

STEERING WHEEL

Номер: US20130112035A1
Автор: Nagata Kenshi
Принадлежит:

There is provided a steering wheel. The steering wheel includes: a rim formed in an annular shape, which is to be gripped by a driver; a hub disposed at the center of the rim in a radial direction of the rim; a spoke connecting the hub to the rim in the radial direction; and a metal core member provided inside the rim, the hub, and the spoke. The metal core member includes: a hub core member provided inside the hub; a spoke core member provided inside the spoke; and a rim core member provided inside the rim. The thickness of the hub core member at the center portion thereof is larger than the thickness of the hub core member at the outer circumferential end portion thereof. 1. A steering wheel comprising:a rim formed in an annular shape, which is to be gripped by a driver;a hub disposed at the center of the rim in a radial direction of the rim;a spoke connecting the hub to the rim in the radial direction; and a hub core member provided inside the hub;', 'a spoke core member provided inside the spoke; and', 'a rim core member provided inside the rim, and, 'a metal core member provided inside the rim, the hub, and the spoke, the metal core member comprisingwherein the thickness of the hub core member at the center portion thereof is larger than the thickness of the hub core member at the outer circumferential end portion thereof.2. The steering wheel according to claim 1 , 'a cylindrical boss formed in a cylindrical shape and projecting from the center of the hub core member and configured to engage with the steering shaft,', 'wherein the metal core member further compriseswherein a rear surface of the hub core member, which faces the steering shaft, is inclined.3. The steering wheel according to claim 2 , wherein the rear surface of the hub core member is curved.4. The steering wheel according to claim 2 ,wherein the hub core member has generally flat uniform thickness portions which are arranged in a left-right direction in a state that the steering wheel is at a ...

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Номер записи: 5
16-05-2013 дата публикации

FOREIGN GENE TRANSFER METHOD BY ELECTROPORATION TECHNIQUE

Номер: US20130122592A1
Автор: Hayakawa Kiyoshi, HAYAKAWA Yasuhiko
Принадлежит: NEPA GENE CO., LTD.

Provided is a method for transferring an extraneous gene by an electroporation technique, which is applicable to a wide range of animal cells and is extremely remarkably improved in viability and gene transferring rate. Also provided is a method for transferring an extraneous gene by an electroporation technique with high viability and gene transferring rate even in the case where no specialized transferring buffer is used. Also provided are: a method for transferring an extraneous gene by an electroporation technique, which is remarkably improved in viability and gene transferring rate, the method including continuously applying, to an animal cell, a first electric pulse (strong electric pulse) and a second electric pulse (weak electric pulse) under specific conditions; and a method for transferring an extraneous gene by an electroporation technique, in which a liquid medium capable of being used for culturing of the animal cell is used as a transferring buffer. 1. A method for transferring an extraneous gene into an animal cell by an electroporation technique , the method comprising: applying , to the animal cell , a first electric pulse having an electric field strength of at least 300 V/cm such that a total calorie strength is 0.2 to 40 J/100 μL; and applying a second electric pulse having an electric field strength of at least 15 V/cm or more such that a calorie strength per pulse is 0.01 to 5 J/100 μl.2. The method of claim 1 , wherein the applying of the second electric pulse is performed two or more times.3. The method of claim 1 , wherein the applying of the second electric pulse is performed less than one minute after the applying of the first electric pulse.4. The method of claim 1 , wherein the animal cell is a mammalian cell.5. The method of claim 1 , wherein the animal cell is an animal cell suspended in a solution.6. The method of claim 5 , wherein the solution comprises a liquid medium suitable for culturing the animal cell.7. The method of claim 1 , ...

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Номер записи: 6
23-05-2013 дата публикации

Microswitch

Номер: US20130126321A1
Автор: Kai Suo
Принадлежит: Nidec Sankyo Corp

Provided is a microswitch wherein the versatility of a lever member can be prevented from being reduced while the rigidity of the lever member is improved. The microswitch is provided with a housing containing a switch mechanism, a plunger which transmits power to the switch mechanism, and a lever member, the base end of which is supported by the housing. In the microswitch, the tip end of the plunger abuts with the bottom surface of the lever member at an intermediate position in the longitudinal direction of the lever member, and an object to be detected can abut with the top surface of the lever member on the tip end side of the lever member. Further, a first reinforcement portion is formed on the top surface of the lever member, excluding an object abutment portion with which the object to be detected is to be abutted, and a second reinforcement portion is formed on the bottom surface of the lever member, excluding a plunger abutment portion

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Номер записи: 7
13-06-2013 дата публикации

KNOB ASSEMBLY AND WASHING MACHINE HAVING THE SAME

Номер: US20130145894A1
Автор: Lee Hong Yeol, Lee Kyung Hwan, PARK Sung Soo
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

A knob assembly having a simple structure allowing an easy assembly, and a washing machine having the same includes a cabinet, a control panel assembly disposed at an upper portion of a front side of the cabinet, and a knob assembly rotatably mounted on the control panel assembly to set a washing cycle, wherein the knob assembly includes a rotation knob configured to rotate while connected to the control panel assembly to set the washing cycle or a function according to a degree of rotation, and a knob cover coupled to the rotation knob to surround the rotation knob. 1. A washing machine comprising:a cabinet;a control panel assembly disposed at an upper portion of a front side of the cabinet; anda knob assembly rotatably mounted on the control panel assembly to set a washing cycle,wherein the knob assembly comprises:a rotation knob configured to rotate while being connected to the control panel assembly to set the washing cycle or a function according to a degree of rotation; anda knob cover coupled to the rotation knob to surround the rotation knob.2. The washing machine of claim 1 , wherein the rotation knob comprises a coupling portion extending from a lateral side of the rotation knob toward a lower side claim 1 , and a plurality of coupling hooks radially protruding from an end portion of the coupling portion outward claim 1 , andthe knob cover comprises a plurality of coupling grooves formed at an inside of a lateral side of the knob cover to correspond to the coupling hooks such that the plurality of coupling hooks are coupled to the plurality of coupling grooves, respectively.3. The washing machine of claim 2 , wherein the plurality of coupling hooks are spaced apart from each other in a circumferential direction around the rotation knob claim 2 , andthe plurality of coupling grooves are spaced apart from each other in a circumferential direction around the knob cover.4. The washing machine of claim 2 , wherein the rotation knob comprises a protrusion ...

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Номер записи: 8
20-06-2013 дата публикации

MEDIUM VOLTAGE CIRCUIT BREAKER ARRANGEMENT OPERATED BY A TRANSMISSION MECHANISM

Номер: US20130153377A1
Автор: Gentsch Dietmar, REUBER Christian
Принадлежит: ABB TECHNOLOGY AG

A circuit breaker arrangement includes at least one pole part for switching an electrical medium to high voltage circuit by a respective pair of fixed and movable electrical contacts. A pushrod of a respective movable electrical contact is operated by a common actuator unit, which is mechanically connected to each pushrod via a transmission mechanism for transferring a switching force from the actuator unit to each pushrod. The transmission mechanism includes a crankshaft having at least one crank which is pivotally attached to one end of a connection rod. An opposite end of the connection rod is pivotally attached to an end of the pushrod of a corresponding pole part. 1. A circuit breaker arrangement comprising:at least one pole part configured to switch an electrical medium to high voltage circuit by a respective pair of a fixed electrical contact and a movable electrical contact;at least one pushrod configured to move a corresponding movable electrical contact of the at least one of pole part, respectively;a common actuator unit configured to operate each pushrod; anda transmission means for transferring a switching force from the actuator unit to each pushrod, the transmission means mechanically connecting the actuator unit to each pushrod,wherein the transmission means includes a crankshaft having at least one crank and at least one connection rod, the at least one crank being pivotally attached to a first end of a corresponding one of the at least one connection rod,wherein a second end of the corresponding one of the at least one connection rod opposite to the first end is pivotally attached to an end of a corresponding one of the at least one pushrod of a corresponding one of the at least one pole part to move the corresponding pushrod.2. The circuit breaker arrangement according to claim 1 , wherein all pole parts are arranged one to another in a line formation.3. The circuit breaker arrangement according to claim 2 , wherein a common upward position of all ...

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Номер записи: 9
27-06-2013 дата публикации

Systems and Methods for Increasing Growth of Biomass Feedstocks

Номер: US20130164812A1
Автор: Green Michael Phillip, Nicholas Eckelberry, Sanchez Pina Jose L
Принадлежит: ORIGINOIL, INC.

Methods and systems for developing and bio-refining or processing biomass feedstocks into a spectrum of bio-based products which can be used as a substitute for fossil oil derivatives in various types of product manufacturing processes and/or the production of bio-energy are disclosed. In addition, methods and systems for identifying, measuring and controlling key parameters in relation to specific biomass developing processes and bio-refining processes so as to maximize the efficiency and efficacy of such processes while standardizing the underlying parameters to facilitate and enhance large-scale production of bio-based products and/or bio-energy are disclosed. 1. A method of increasing biomass feedstock production yield by exposing the biomass feedstock to an electromagnetic field.2. A system of increasing biomass feedstock production yield , the system having two or more electrodes being configured to expose the biomass feedstock to an electromagnetic field.3. The system and method of and , wherein the electromagnetic field is of a magnitude lower than that which would cause electrolysis within a liquid medium containing the biomass feedstock.4. A method of increasing growth of photosynthetic organisms in a liquid medium , comprising exposing:providing a liquid medium containing photosynthetic organisms; andexposing the liquid medium to an electromagnetic field, the electromagnetic field having a lower magnitude than that which would cause electrolysis within the liquid medium.5. The method of claim 4 , wherein exposing the liquid medium to an electromagnetic field further comprises disposing at least two electrodes within the liquid medium and providing a voltage differential between the at least two electrodes.6. The method of claim 5 , wherein the voltage differential is less than or equal to 1.23 V when the liquid medium is substantially a salt water medium.7. The method of claim 5 , wherein the voltage differential is less than or equal to 1.8 V when the ...

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Номер записи: 10
04-07-2013 дата публикации

Circuit breaker provided with mechanical trip mechanism

Номер: US20130168213A1
Автор: Hong Ik Yang, Jong Doo Kim, Kil Young Ahn
Принадлежит: LSIS Co Ltd

A circuit breaker having a mechanical trip mechanism enabling a circuit breaker to perform an emergency manual trip operation is provided. The circuit breaker includes: a fixed contactor connected to a circuit; a movable contactor movable to a closed state in which the movable contactor is in contact with the fixed contactor and a broken state in which the movable contactor is separated from the fixed contactor, an opening and closing mechanism configured to convert a rotational motion of a plurality of links and a rotational shaft to enable the movable contactor to be brought into contact with the fixed contactor or separated therefrom; a trip latch locked to or unlocked from a main link provided in the opening and closing mechanism; and an OFF button configured to rotate the trip latch to unlock the trip latch from the main link when manually pressed.

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Номер записи: 11
04-07-2013 дата публикации

Lockout Switch Apparatus and Method

Номер: US20130168985A1
Автор: Mongan Dan Eugene
Принадлежит: The Caldwell Group, Inc.

An improved apparatus and/or method for safely lifting a load along a lift axis are provided, through utilization of an automatic lockout arrangement operatively connected between the point of application of a lifting force and a motorized clamping arrangement for grasping the load. 1. A lifting apparatus for lifting a load along a lift axis , the apparatus comprising:an electrically operable clamping arrangement having clamping elements movable between an open and a closed position of the clamping arrangement for selectively grasping and releasing the load; andan electrical lockout arrangement connected at a lower end thereof to the clamping arrangement and having an upper end thereof adapted for application of a lifting force along the lifting axis;the electrically operable clamping arrangement and the electrical lockout arrangement being cooperatively configured such that the electrical lockout arrangement precludes electrical power from being applied to open the clamping arrangement when the lifting force being applied to the upper end of the electrical lockout arrangement has reached a predetermined lockout value while the clamping arrangement is grasping the load;the electrically operable clamping arrangement and the electrical lockout arrangement also being cooperatively configured such that the electrical lockout arrangement allows electrical power to be applied to the clamping arrangement for opening the clamping arrangement when the lifting force being applied to the upper end of the electrical lockout arrangement is below the predetermined lockout value.2. The lifting apparatus of claim 1 , wherein claim 1 , the predetermined lockout value of the lifting force is adjustable.3. The lifting apparatus of claim 2 , wherein the predetermined lockout value is a function of a spring constant of at least one spring of the electrical lockout arrangement.4. The lifting apparatus of claim 3 , wherein the at least one spring includes multiple springs arranged in a ...

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Номер записи: 12
11-07-2013 дата публикации

OPERATING DEVICE

Номер: US20130175147A1
Автор: AOKI Yoshiyuki, HISADA Masahito, TAKANO Yoshinori
Принадлежит: KABUSHIKI KAISHA TOKAI RIKA DENKI SEISAKUSHO

An operating device includes a dial that has a first engagement portion, a rotational body that is formed in an annular shape, and has a second engagement portion so as to be engaged with the first engagement portion of the dial. Rotation of the dial is transmitted to the rotational body through an engagement of the first and second engagement portions. The operating device also includes gear teeth that are provided on an inner circumferential portion of the rotational body, a gear that is meshed with the gear teeth and is rotated in an inner space of the rotational body, and a rotation response member that is directly coupled to a rotation shaft of the gear and varies in accordance with a rotation angle of the dial. 1. An operating device comprising:a dial that has a first engagement portion;a rotational body that is formed in an annular shape, and has a second engagement portion so as to be engaged with the first engagement portion of the dial, wherein rotation of the dial is transmitted to the rotational body through an engagement of the first and second engagement portions;gear teeth that are provided on an inner circumferential portion of the rotational body;a gear that is meshed with the gear teeth and is rotated in an inner space of the rotational body; anda rotation response member that is directly coupled to a rotation shaft of the gear and varies a physical amount in accordance with a rotation angle of the dial.2. The operating device according to claim 1 , wherein the rotational body is arranged in an inner space of the dial.3. The operating device according to claim 1 , wherein a rotational axis of the dial and the rotation shaft of the gear are coaxially arranged to each other.4. The operating device according to claim 1 , wherein one of the first and second engagement portions is an engagement hole claim 1 , and the other of the first and second engagement portions is an engagement projection. The present invention relates to a dial type operating ...

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Номер записи: 13
18-07-2013 дата публикации

LEVER SWITCH

Номер: US20130180836A1
Автор: NERIKI Nobuaki, NISHIKAWA HISASHI
Принадлежит: Panasonic Corporation

A lever switch includes a case, a lever, a wiring board, a sliding body, and a movable contact. The wiring board has fixed contacts and is disposed at an opposite side to the lever with respect to the case. The sliding body has a sliding part and a second arm part having a supporting portion, and is disposed between the case and the wiring board. The movable contact is mounted to the sliding part and has an end to be brought into contact with the fixed contact. A first arm part of the lever extends from the main body part through the case and the wiring board. The second arm part extends from the wiring board through the sliding part. The holding portion and the supporting portion are engaged with each other at an opposite side to the case with respect to the wiring board. 1. A lever switch comprising:a case;a lever having an operating part, a main body part, and a first arm part having a holding portion at a tip thereof, the main body part being rotatably mounted to the case;a wiring board having a fixed contact and being disposed at an opposite side of the case with respect to the operating part;a sliding body having a sliding part, and a second arm part having a supporting portion at a tip thereof and being disposed between the case and the wiring board; anda movable contact mounted to the sliding part and having an end to be brought into contact with the fixed contact,wherein the first arm part extends from the main body part through the case and the wiring board,the second arm part extends from the sliding part through the wiring board, andthe holding portion and the supporting portion are engaged with each other at an opposite side of the case with respect to the wiring board.2. The lever switch of claim 1 ,wherein the end of the movable contact has a plurality of contact portions including a first contact portion and a second contact portion,the fixed contact is one of a plurality of fixed contacts including a first fixed contact and a second fixed contact, ...

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Номер записи: 14
01-08-2013 дата публикации

ELECTROPORATION ELECTRODE CONFIGURATION AND METHODS

Номер: US20130196441A1
Автор: Rubinsky Boris, Troszak Gregory D.
Принадлежит: The Regents of the University of California

Provided herein are the concept that “singularity-based configuration” electrodes design and method can produce in an ionic substance local high electric fields with low potential differences between electrodes. The singularity-based configuration described here includes: an anode electrode; a cathode electrode; and an insulator disposed between the anode electrode and the cathode electrode. The singularity-based electrode design concept refers to electrodes in which the anode and cathode are adjacent to each other, placed essentially co-planar and are separated by an insulator. The essentially co-planar anode/insulator/cathode configuration bound one surface of the volume of interest and produce desired electric fields locally, i.e., in the vicinity of the interface between the anode and cathode. In an ideal configuration, the interface dimension between the anode and the cathode tends to zero and becomes a point of singularity. 1. A singularity-based electrode configuration , comprising:an anode electrode;a cathode electrode; andan insulator disposed between the anode electrode and the cathode electrode, wherein the anode electrode, insulator, and cathode electrode are positioned co-planar with respect to one another.2. The singularity-based electrode configuration of claim 1 , further comprising:an ionic substance in contact with the anode electrode, insulator, and cathode electrode.3. The singularity-based electrode configuration of claim 1 , wherein the insulator separates the anode electrode from the cathode electrode by between five nanometers and five microns.4. The singularity-based electrode configuration of claim 1 , wherein the insulator separates the anode electrode from the cathode electrode by between 50 nanometers and two microns.5. The singularity-based electrode configuration of claim 1 , wherein the insulator separates the anode electrode from the cathode electrode by about 100 nm.6. The singularity-based electrode configuration of claim 1 , ...

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Номер записи: 15
08-08-2013 дата публикации

METHOD FOR INDUCING DIFFERENTIATION OF ADULT STEM CELLS AND NERVE CELLS USING ELECTROMAGNETIC FIELD

Номер: US20130202565A1
Автор: CHO Hyun Jin, Kim Soo Chan, KIM Sung Min, Park Jung-Keug, Seo Young-Kwon, Yoon Hee Hoon, Yoon Moon Young
Принадлежит: Dongguk University Industry-Academic Cooperation Foundation

The present invention relates to a method for differentiation of mesenchymal stem cells or dental pulp stem cells. More specifically, the invention relates to a method for differentiating stem cells to neural cells by applying mesenchymal stem cells or dental pulp stem cells with a low-frequency electromagnetic field. The differentiation method according to the present invention can induce differentiation even with low-cost mediums rather than induced neural differentiation mediums which are expensive due to addition of growth factors, and the neural cells differentiated according to the present invention may be useful for treatment of neurological brain diseases. 18.-. (canceled)9. A method for differentiation of mesenchymal stern cells or adult stem cells into neural cells comprising applying an electromagnetic field to the mesenchymal stem cells or adult stem cells.10. The method of claim 9 , wherein the neural cells comprises astrocytes or oligodendrocytes.11. The method of claim 9 , wherein the electromagnetic field is applied at a frequency of 1 to 1000 Hz.12. The method of claim 9 , wherein the electromagnetic field is applied at a flux density of 1 to 5 mT.13. The method of claim 9 , wherein the mesenchymal stem cells are derived from bone marrow claim 9 , adipose claim 9 , or umbilical cord.14. The method of claim 9 , wherein the adult stem cells are dental pulp stem cells.15. A composition for treatment of neurological diseases comprising the neural cells differentiated by the method of .16. The composition of claim 15 , wherein the neurological diseases is Alzheimer's disease claim 15 , depression claim 15 , Parkinson's disease claim 15 , cerebral infarction claim 15 , cerebral hemorrhage claim 15 , or spinal cord injuries.17. A method of treating a patient comprising administering the neural cells of to the patient. The present invention relates to a method for differentiation of mesenchymal stem cells or adult stem cells. More specifically, the present ...

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Номер записи: 16
08-08-2013 дата публикации

METHOD FOR INDUCING DIFFERENTIATION OF MESENCHYMAL STEM CELLS TO NERVE CELLS USING SOUND WAVES

Номер: US20130202566A1
Автор: CHO Hyun Jin, Jeon Song Hee, Park Jung-Keug, Seo Young-Kwon, Yoon Hee Hoon, Yoon Moon Young
Принадлежит: Dongguk University Industry-Academic Cooperation Foundation

The present invention relates to a method for differentiation of mesenchymal stem cells. More specifically, the invention relates to a method for differentiating mesenchymal stem cells to neural cells by treating the mesenchymal stem cells with low-frequency sound waves. The differentiation method of the present invention can induce differentiation even with low-cost media rather than induced neural differentiation mediums which are expensive due to addition of growth factors, and the neural cells differentiated according to the present invention may be useful for treatment of neurological diseases. 18.-. (canceled)9. A method for differentiation of mesenchymal stem cells into neural cells comprising applying a sound wave to the mesenchymal stem cells.10. The method of claim 9 , wherein the sound wave is applied at a frequency of 1 to 500 Hz.11. The method of claim 9 , wherein the sound wave is applied at a frequency of 30 to 300 Hz.12. The method of claim 9 , wherein the sound wave is applied at an intensity of 0.1 to 5 V.13. The method of claim 9 , wherein the sound wave is applied at an intensity of 0.5 to 3 V.14. The method of claim 9 , wherein the mesenchymal stem cells are derived from bone marrow claim 9 , fat claim 9 , umbilical cord blood claim 9 , or umbilical cord.15. A composition for treatment of neurological diseases comprising the neural cells differentiated by the method of .16. The composition of claim 15 , wherein the neurological diseases is Alzheimer's disease claim 15 , depression claim 15 , Parkinson's disease claim 15 , cerebral infarction claim 15 , cerebral hemorrhage claim 15 , or spinal cord injury.171. A method of treating a patient comprising administering the neural cells of claim to a patient. The present invention relates to a method for differentiation of mesenchymal stem cells. More specifically, the present invention relates to a method for differentiating mesenchymal stem cells into neural cells by applying a sound wave of a ...

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Номер записи: 17
08-08-2013 дата публикации

Continuous Flow Bioreactor for Magnetically Stabilized Three-Dimensional Tissue Culture

Номер: US20130203145A1
Автор: Dominko Tanja, Lambert Christopher R., McGimpsey W. Grant, Page Raymond L.
Принадлежит:

The invention provides methods for rapid, continuous generation of cells and cell products using magnetically stabilized three-dimensional tissue culture. The invention also pertains to a continuous flow self-regulating closed system bioreactor system for magnetically stabilized three-dimensional tissue culture. The methods described here do not use traditional solid scaffolding for cell culture. 1. A bioreactor for culturing cells , comprising:a vessel,an apparatus for conveying fluids,magnetic beads having cells attached thereon, andan apparatus for conveying a magnetic field.2. The bioreactor of claim 1 , further comprisingan apparatus for dialysis, andan apparatus for harvesting.3. The bioreactor of further comprising an apparatus for photoelectrochemical processing.4. (canceled)5. (canceled)6. The bioreactor of claim 1 , where the magnetic bead size is 100 nm to 10 μm.7. The bioreactor of claim 1 , wherein more than one type of cell is attached.8. (canceled)9. (canceled)9a. (canceled)9b. (canceled)10. A system for cultivating cells claim 1 , comprising:a bioreactor,magnetic beads having cells attached thereon,an apparatus for conveying a magnetic field, andan apparatus for conveying a continuous flow of fluids, wherein the cells are controlled by the magnetic field and the flow of fluids.11. (canceled)12. (canceled)13. A method for culturing cells in a bioreactor comprising:providing cells attached to magnetic beads,acting upon the cells with a fluid,acting upon the cells with a magnetic field, andallowing the cells to grow and proliferate.14. The method of claim 13 , wherein the cells form a tissue.15. The method of claim 14 , wherein the tissue has a lumen.16. The method of claim 13 , wherein the cells are grown without scaffolding.17. The method of claim 13 , wherein the cells are mammalian cells.18. The method of claim 17 , wherein the mammalian cells are selected from lymphocytes claim 17 , smooth muscle cells claim 17 , stem cells claim 17 , cardiac cells ...

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Номер записи: 18
15-08-2013 дата публикации

ARTHROSCOPE ROTATION MECHANISMS AND METHODS OF ENDOSCOPIC ROTATION

Номер: US20130205936A1
Автор: Frith Martin A., PAULI Sabine, Schmieding Reinhold, Seeh Daniel, Speier Craig
Принадлежит: Arthrex, Inc.

A rotation mechanism (rotating device) that can be easily accessed by the surgeon's finger to rotate an endoscope or similar instrument. The rotation mechanism is a device/component with a “starfish” configuration, which can be attached to the endoscope/arthroscope just distal to the eyepiece (or to an alternate attachment to a camera). The starfish component has a plurality of projections that extend radially from the endoscope axis, and beyond the diameter of the mechanism on the camera head that grasps the arthroscope eyecup. The projections can be easily accessed by the surgeon's finger to rotate the endoscope. 1. An endoscope , comprising:a shaft comprising a longitudinal axis, a proximal end and a distal end; anda rotating device attached to the shaft, the rotating device comprising a plurality of arms that extend radially from the longitudinal axis of the shaft and that are actuated by an operator's finger to rotate the rotating device and the shaft.2. The endoscope of claim 1 , wherein the endoscope further comprises a port located at the proximal end of the shaft and extending away from the shaft and in a direction non-parallel to the longitudinal axis of the shaft claim 1 , and an eyepiece or attachment to a camera claim 1 , the eyepiece or the attachment to the camera being located proximally to the port claim 1 , and wherein the rotating device is provided between the port and the eyepiece or the attachment to the camera.3. The endoscope of claim 2 , wherein the port is a light port and the endoscope comprises an eyepiece so that the rotating device is provided between the light port and the eyepiece claim 2 , and wherein the plurality of arms of the rotating device extend radially beyond an outer diameter of the eyepiece to allow access by an operator's finger to rotate the rotating device and the shaft.4. The endoscope of claim 3 , wherein the rotating device further comprises a collet that is configured to snap-fit onto the light port.5. The endoscope ...

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Номер записи: 19
15-08-2013 дата публикации

SWITCHING UNIT FOR AN ELECTRICAL SWITCHING DEVICE

Номер: US20130206558A1
Автор: BUNK Thomas, Hierl Andreas, MAYER Bernhard, PIRKER Siegfried, POHLE Christian
Принадлежит:

A switching unit for an electrical switching device, in particular an electrical circuit breaker, is disclosed. The switching unit includes a switching lock with a switching mechanism and a rotor housing with a contact arm disposed therein for opening and closing contacts during a rotation of the rotor housing about a rotation axis. In an embodiment, at least one lever apparatus is functionally connected at its upper end by way of the switching mechanism and at its lower end by way of a connecting pin to a face of the rotor housing. 1. A switching unit for an electrical switching device , comprising:a switching lock including a switching mechanism and a rotor housing with a contact arm disposed therein for opening and closing contacts during a rotation of the rotor housing about a rotation axis; andat least one lever apparatus, functionally connected at an upper end to the switching mechanism and functionally connected at a lower end by way of a connecting pin to a face of the rotor housing.2. The switching unit of claim 1 , wherein the connecting pin is configured as a separate component from the at least one lever apparatus and the rotor housing.3. The switching unit of claim 2 , wherein a pin holder is disposed on at least one face of the rotor housing claim 2 , the pin holder being configured to accommodate the connecting pin.4. The switching unit of claim 2 , wherein the at least one lever apparatus includes a passage at the lower end claim 2 , configured to accommodate the connecting pin.5. The switching unit of claim 1 , wherein the connecting pin extends at least in segments along a pin axis claim 1 , disposed parallel or essentially parallel to the rotation axis of the rotor housing.6. The switching unit of claim 1 , wherein the connecting pin extends along a pin axis claim 1 , disposed at a distance from the rotation axis of the rotor housing.7. The switching unit of claim 1 , wherein the at least one lever apparatus includes two lever apparatuses claim 1 ...

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Номер записи: 20
15-08-2013 дата публикации

POWER SOURCE CIRCUIT SHUTOFF DEVICE

Номер: US20130206559A1
Автор: HENMI Fumitoshi, IKEDA Tomohiro, Mochizuki Kouichiro, Nogashira Sho, Ohike Teruhiko, TAKISHITA Ryuta
Принадлежит: Yazaki Corporation

A power source circuit shutoff device includes: a base housing including a first mating wall and a cam pin; a lever housing including a second mating wall; and an operation lever rotatably supported to the lever housing and having a cam groove for guiding the cam pin. The base housing and the lever housing are set to a lever mating start position in which the first mating wall and the second mating wall are partly overlapped with each other and the cam pin is entered into the cam groove of the operation lever, and a rotation of the operation lever moves the cam pin in the cam groove to thereby cause a mating force between the first mating wall and the second mating wall. The base housing and the lever housing respectively have restriction ribs. 1. A power source circuit shutoff device comprising: a first mating wall having a first terminal disposed therein, and', 'a cam pin;, 'a base housing including 'a second mating wall having a second terminal disposed therein; and', 'a lever housing includingan operation lever rotatably supported to the lever housing and having a cam groove for guiding the cam pin,wherein:the base housing and the lever housing are set in a lever mating start position in which the first mating wall and the second mating wall are partly overlapped with each other and the cam pin is entered into the cam groove of the operation lever, and a rotation of the operation lever moves the cam pin in the cam groove to thereby cause a mating force between the first mating wall and the second mating wall, thereby proceeding a mating between the first mating wall and the second mating wall, and the first terminal and the second terminal are electrically connected in a lever mating completion position, andthe base housing and the lever housing respectively have restriction ribs configured to be engaged with each other between the lever mating start position and the lever mating completion position to thereby guide the mating and separating between the first ...

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Номер записи: 21
15-08-2013 дата публикации

IN-VEHICLE LEVER SWITCH DEVICE

Номер: US20130206564A1
Автор: Kosaka Ken
Принадлежит: ALPS ELECTRIC CO., LTD.

In a lever switch device, a holder is assembled in and fixed to a cylindrical lever body formed by combining halved lever bodies and the holder supports two rotating knobs so as to allow the rotating knobs to rotate. Further, a circuit board is mounted on the holder, and both main surfaces of the circuit board face the rotating knobs, respectively. The rotating knob is exposed to the outside at the end of the cylindrical lever body in the axial direction, and the rotating knob is exposed to the outside through window portions formed at the cylindrical lever body. Sliders are mounted on the rotating knobs, respectively, one slider can come into contact with and be separated from contact patterns formed on the main surface, and the other slider can come into contact with and be separated from contact patterns formed on the main surface. 1. An in-vehicle lever switch device comprising:a cylindrical lever body;a first rotating knob and a second rotating knob that are supported so as to be rotatable along an plane orthogonal to an axial direction of the cylindrical lever body; anda circuit board that is assembled in the cylindrical lever body so as to be oriented along the orthogonal plane,wherein a first rotation detection portion, which is used to detect the rotation of the first rotating knob, is provided on one main surface of the circuit board,a second rotation detection portion, which is used to detect the rotation of the second rotating knob, is provided on the other main surface of the circuit board,the cylindrical lever body comprises a combined pair of halved lever bodies,the first and second rotating knobs are rotatably supported by a holder that is assembled in and fixed to the cylindrical lever body,the circuit board is mounted on the holder between the first and second rotating knobs,the first rotating knob is exposed to the outside at an end of the cylindrical lever body in the axial direction, andthe second rotating knob is exposed to the outside through ...

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Номер записи: 22
15-08-2013 дата публикации

METHOD FOR CONTROLLING THE CHAPERONE ACTIVITY OF PEROXIREDOXINS USING IRRADIATION

Номер: US20130210108A1
Автор: An Byung Chull, Bai Hyoung-Woo, Chung Byung Yeoup, Lee Eun Mi, Lee Jae Taek, LEE Seung Sik
Принадлежит:

The present invention relates to a method for increasing chaperone activity by irradiating peroxiredoxin (Prx) proteins. More particularly, the present invention may be useful for preparing recombinant proteins imparting resistance against various environmental stresses by increasing the chaperone activity of peroxiredoxin, since it has been observed that irradiated peroxiredoxin has enhanced chaperone activity characteristics, wherein an α-helix structure decreases while a β-sheet structure increases, from analysis results of a protein structure change and chaperone activity after irradiating two types of peroxiredoxins (2-Cys, 3-Cys) which are two active cysteine motifs of peroxiredoxin. 1. A method for increasing chaperone activity by irradiating peroxiredoxin protein.2. The method for increasing chaperone activity according to claim 1 , wherein the peroxiredoxin protein is 2-Cys peroxiredoxin having two or three cysteine residues.3. The method for increasing chaperone activity according to claim 2 , wherein the peroxiredoxin protein has the amino acid sequence represented by SEQ. ID. NO: 1 or SEQ. ID. NO: 2.4. The method for increasing chaperone activity according to claim 1 , wherein the radiation is selected from the group consisting of gamma ray claim 1 , electron beam (beta ray) claim 1 , and UV.5. The method for increasing chaperone activity according to claim 4 , wherein the dose of gamma ray is 1˜500 kGy.6. The method for increasing chaperone activity according to claim 4 , wherein the dose of gamma ray is 1˜30 kGy.7. The method for increasing chaperone activity according to claim 4 , wherein the dose of UV is 5˜240 W.8. A peroxiredoxin protein with increased chaperone activity prepared by the method of .910-. (canceled)11. A method for increasing chaperone activity by the gamma ray or UV irradiating 2-Cys or 3-cys peroxiredoxin protein having two or three cysteine residues.12. The method for increasing chaperone activity according to claim 11 , wherein ...

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Номер записи: 23
29-08-2013 дата публикации

Light-Activated Chimeric Opsins and Methods of Using the Same

Номер: US20130224821A1
Автор: Deisseroth Karl, Fenno Lief, Hegemann Peter, Prigge Matthias, Yizhar Ofer
Принадлежит: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons. 151.-. (canceled)52. An isolated light-responsive chimeric polypeptide comprising an amino acid sequence having at least about 85% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO:1.53. The chimeric polypeptide of claim 52 , wherein the polypeptide is activated by light of a wavelength between about 540 nm to about 560 nm.54. The chimeric polypeptide of claim 52 , further comprising a C-terminal trafficking signal.55. The chimeric polypeptide of claim 54 , wherein the trafficking signal comprises the amino acid sequence KSRITSEGEYIPLDQIDINV (SEQ ID NO:15).56. The chimeric polypeptide of claim 52 , wherein the light-responsive chimeric polypeptide comprises an amino acid sequence having at least about 90% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO:1.57. The chimeric polypeptide of claim 52 , wherein the light-responsive chimeric polypeptide comprises an amino acid sequence having at least about 95% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO:1.58. An isolated polynucleotide comprising a nucleotide sequence encoding the polypeptide of .59. The isolated polynucleotide of claim 58 , wherein the nucleotide sequence is operably linked to a promoter.60. The polynucleotide of claim 58 , wherein the polynucleotide is an expression vector.61. The polynucleotide of claim 60 , wherein the expression vector is a viral vector.62. A mammalian cell comprising the polynucleotide of claim 58 , wherein the light-responsive chimeric polypeptide is present in the cell membrane.63. The mammalian cell of claim 62 , wherein the cell is a neuronal cell claim 62 , a muscle cell claim 62 , or a stem cell.64. The mammalian cell of claim 62 , wherein the cell is an excitatory neuronal cell or an ...

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Номер записи: 24
29-08-2013 дата публикации

MODIFICATION OF MICROALGAE FOR MAGNETIC PROPERTIES

Номер: US20130224822A1
Автор: Postier Brad, Sayre Richard
Принадлежит:

Genetically engineered algae strains for biofuels and bioproduct production have improved iron utilization including iron uptake and storage, and exhibit improved growth characteristics, magnetic separation, and magnetic hysteresis induced cell lysis. Pond production algal strain embodiments with high iron scavenging capabilities limit iron availability to contaminating microorganisms and invading species. Accumulation of high iron and other paramagnetic elements content in the form of ferritin enhances the cells magnetic susceptibility improving efficiency of magnetic separation and magnetic hysteresis induced cell lysis. Several genes of the embodiments are capable of improving iron acquisition including the ferritin gene fer1, iron transport gene fea1, and iron reductase gene fre1. Other genes which improve growth in the high iron conditions permitting higher accumulation of iron include radical scavenging enzymes such as superoxide dismutase, peroxidase, catalase, glutathione peroxidase and the Ferritin like DPR/DPS genes which also bind iron and protect DNA from reactive oxygen species. 1. A method of separating genetically modified algae from an associated suspending liquid medium , the method comprising:modifying wild-type algae so that one or more cellular iron assimilation components are enhanced under control of a constitutive or regulated promoter to produce genetically modified algae in an associated suspending liquid medium; and,exposing the genetically modified algae to an associated magnetic field to magnetically separate the genetically modified algae from an associated suspending liquid medium.2. The method of wherein the modifying comprises:modifying the algae to tolerate growth under high iron conditions through introduction of genes involved in alleviating iron stress including reactive oxygen species production.3. The method of wherein the introduction of genes comprises:an introduction of reactive oxygen species responsive genes belonging to ...

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Номер записи: 25
05-09-2013 дата публикации

Panel for a Domestic Appliance Having a Rotary Switch, and Domestic Appliance

Номер: US20130228038A1
Автор: Klimecki Marek
Принадлежит: PAS DEUTSCHLAND GMBH

A panel for a domestic appliance having a rotary switch, the rotary switch having a rotary element, a latching ring, at least one latching element and a rotation axis about which the rotary element rotates relative to the latching ring, wherein the latching ring has at least one latching lug on its inner face, said latching lug projecting radially toward the center the latching ring, wherein the latching element is held on the rotary element and is prestressed radially outward against the inner face of the latching ring, wherein the rotary element and the latching ring are arranged along the rotation axis, and wherein the latching ring is arranged in a rotationally fixed manner on the panel. A corresponding domestic appliance having a panel is also disclosed. 1. A panel for a domestic appliance having a rotary switch , the rotary switch having a rotary element , a latching ring , at least one latching element and a rotation axis about which the rotary element rotates relative to the latching ring , wherein the latching ring has at least one latching lug on its inner face , said latching lug projecting radially toward a center of the latching ring , wherein the latching element is held on the rotary element and is prestressed radially outward against the inner face of the latching ring , wherein the rotary element and the latching ring are arranged along the rotation axis , and wherein the latching ring is arranged in a rotationally fixed manner on the panel.2. The panel of claim 1 , wherein the rotary element has a first shaped part and a second shaped part which are arranged along the rotation axis.3. The panel of claim 2 , wherein the latching element is arranged in a moveable manner on at least one shaped part selected from the first shaped part and the second shaped part.4. The panel of claim 1 , wherein the first shaped part and the second shaped part are separate from one another and are connected to one another for joint rotary movement about the rotation ...

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Номер записи: 26
05-09-2013 дата публикации

METHOD AND DEVICE FOR UNIFORMLY TREATING ADHERENT CELLS

Номер: US20130230895A1
Автор: Gleissner Timo, Heinze Andreas, Koblizek Thomas, Mueller-Hartmann Herbert, Wirth Andreas
Принадлежит: LONZA COLOGNE GMBH

The invention relates to a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes wherein at least three electrodes are provided, and wherein at least two electrodes are active electrodes when the voltage is applied in order to generate a first electric field, and in which at least one second electric field is generated, wherein at least one of the two previously active electrodes is a potential-free electrode when the voltage is applied. The invention further relates to a device comprising at least three electrodes which are connected to at least one voltage source by means of at least one switching device wherein at least five electrodes are connected to the at least one voltage source by means of four switching devices wherein at least two electrodes are connected to the voltage source by means of a common switching device In conjunction with the method described above, the device according to the invention allows the efficient and uniform treatment of adherent cells using an electric field, wherein the switch between active and potential-free electrodes can be carried out quickly and safely using a lower number of switching devices. 1. Method for applying at least one electric field to adherent cells , in which the electric field is generated by applying a voltage to at least two active electrodes , comprisingproviding at least three electrodes wherein at least two of said electrodes are active electrodes when the voltage is applied for generating a first electric field, and that at least a second electric field is generated, wherein at least one of the two former active electrodes is a floating electrode when the voltage is applied.2. The method according to claim 1 , wherein as many electric fields as necessary are generated during generation of further electric fields to make at least once floating electrodes out of all electrodes that have been ...

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Номер записи: 27
12-09-2013 дата публикации

ROTARY OPERATION DEVICE

Номер: US20130233106A1
Автор: OOSAWA Yasuhiro
Принадлежит: SUMITOMO WIRING SYSTEMS, LTD.

A rotary operation device that can prevent misassembly of a rotary operation member and a rotational force transmission member, has a rotary operation member, a rotation detector, and a rotational force transmission member. The rotary operation member has a first gear and the rotational force transmission member has a second gear and a transmission axis. One of the rotary operation member and the rotational force transmission member has a first interference portion that interferes with the other member in a position misaligned from a proper engagement position where the first gear and the second gear are engaged in a proper phase relationship. The other member comprises a second interference member that interferes with the first interference portion in a position misaligned from the proper engagement position and an escape portion that receives the first interference portion in the proper engagement position to allow assembly with the one member. 1. A rotary operation device comprising:a rotary operation member rotated around a rotation axis;a rotation detector detecting rotary operation of the rotary operation member; anda rotational force transmission member transmitting, to the rotation detector, a rotational force generated in association with the rotary operation of the rotary operation member, 'a first gear transmitting the rotational force of the rotary operation member to the rotational force transmission member,', 'the rotary operation member comprising a second gear engaged with the first gear; and', 'a transmission axis linked to the second gear, rotatable around a central axis thereof, and coupled with the rotation detector, wherein, 'the rotational force transmission member comprisingone of the rotary operation member and the rotational force transmission member comprises a first interference portion provided in a portion displaced in a rotation direction in accordance with rotation thereof and having a shape that interferes with the other of the rotary ...

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Номер записи: 28
19-09-2013 дата публикации

STEERING WHEEL

Номер: US20130239739A1
Автор: Kondou Takashi, Kunitake Yukihiro, Miyahara Kunitomo, ONOHARA Keisuke, Wakai Takashi
Принадлежит: HONDA MOTOR CO., LTD.

There is provided a steering wheel that can reduce the load applied to an elastic body included in a dynamic damper to lengthen the life of the dynamic damper, and that allows the frequency of the dynamic damper to be adjusted easily. An insulator includes a first flange portion provided between a stopper and an elastic body and a second flange portion provided between a coil spring and the elastic body The elastic body includes a first diameter-increased portion increased in diameter to be contactable with the first flange portion and a second diameter-increased portion increased in diameter to be contactable with the second flange portion A contact surface of the first flange portion with the first diameter-increased portion has a plurality of linear projections arranged in a substantially radial fashion. 1. A steering wheel including a main body assembled on a steering shaft for converting a rotating action into a steering action , and a pad unit provided at almost the center of the main body , the pad unit being assembled to the main body such as to be movable in an axis direction of the steering shaft , and a horn switch being provided between the main body and the pad unit ,wherein the steering wheel comprises a first horn plate fixed to the main body, a second horn plate fixed to the pad unit, a guide pin standing on one of the first horn plate and the second horn plate, a stopper provided at a distal end of the guide pin, an insulator inserted slidably along the guide pin, an elastic body fitted on an outer periphery of the insulator, a protector fitted on an outer periphery of the elastic body and provided engageably with the other of the first horn plate and the second horn plate, and a coil spring fitted on the guide pin to bias the insulator toward the stopper,wherein the insulator includes a first flange portion provided between the stopper and the elastic body, and a second flange portion provided between the coil spring and the elastic body, and the ...

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Номер записи: 29
03-10-2013 дата публикации

THROTTLE CONTROL APPARATUS FOR A SADDLE-TYPE VEHICLE, AND VEHICLE INCLUDING SAME

Номер: US20130255432A1
Автор: NAKAYAMA Masaru, NOMURA Yoshihiro, SHIGEMIZU Nobuo, TAMAKI Kenji, TANAKA Kunihiko
Принадлежит: HONDA MOTOR CO., LTD.

A throttle control apparatus is configured to be capable of easy assembly. The throttle control apparatus also includes a rotor and an intermediate casing, which surrounds a portion of the rotor. The intermediate casing also houses a position sensor for detecting a rotational angle of the rotor. The rotor and the intermediate casing are both encased in an outer housing, which is configured and adapted to be mounted on a motorcycle handlebar. A return spring, for returning the rotor to an original position, has one end engaged with a first retaining pin on the rotor, and the other end of the return spring is engaged with a second retaining pin on the intermediate casing. 1. A throttle control apparatus which is configured to be mounted on a handlebar of a vehicle , the throttle control apparatus comprising:a rotor which is pivotally movable by a user via rotation of a throttle grip;a intermediate case which surrounds a portion of the rotor, wherein the intermediate case is adapted to be non-rotatably affixed to the handlebar in an installed position of the apparatus;a outer housing which houses the rotor and the intermediate case therein, and is adapted to be mounted on the handlebar;a position sensor disposed in the intermediate case for detecting a rotational angle of the rotor; anda return spring for returning the rotor to an original position after rotation thereof;wherein the return spring has a first end operatively connected to the rotor, and a second end operatively connected to the intermediate case.2. The throttle control apparatus according to claim 1 , wherein the rotor includes an engaging member claim 1 , and the first end of the spring is engaged with the engaging member.3. The throttle control apparatus according to claim 1 , wherein the outer housing comprises at least one rib for limiting pivotal movement of the throttle grip.4. The throttle control apparatus according to claim 1 , wherein engaging portions are formed on the throttle grip and the ...

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Номер записи: 30
03-10-2013 дата публикации

Control wheel for aeronautics

Номер: US20130255436A1
Автор: David Astier, Nicolas Palusinski, Thierry Vinard, Vincent Mangin
Принадлежит: Crouzet Automatismes SAS

The invention concerns a control wheel ( 100 ) for aeronautics constituted of at least two half-shells ( 10 ) assembled one to the other, said half-shells comprising reinforcing ribs ( 11 ) on their internal surface, positioning and fixing means ( 12 ) and locating holes ( 13 ) to allow the passage of electrical wires connecting electrical actuating means ( 20 ) to a control unit. The control wheel ( 100 ) includes a central opening ( 15 ) intended to be connected to a control shaft/hub. The wheel comprises an intermediate guide part ( 50 ) disposed between the half-shells ( 10 ) and positioned inside the control wheel ( 100 ), said part including at least one guide conduit ( 51 ) adapted to connect on the one hand a locating hole ( 13 ) to the central opening ( 15 ) of the control wheel ( 100 ).

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Номер записи: 31
03-10-2013 дата публикации

METHOD AND ELECTRODE ASSEMBLY FOR TREATING ADHERENT CELLS

Номер: US20130260434A1
Автор: Mueller-Hartmann Herbert, Wirth Andreas
Принадлежит: LONZA COLOGNE GMBH

The invention relates to an electrode assembly in particular for applying at least one electric field to adherent cells, comprising at least two electrodes each having at least one surface which is arranged opposite the corresponding surface of the other electrode wherein an electrically insulating material is arranged at least partially between the surfaces of the electrodes The solution according to the invention allows the electric field to be concentrated in the region of the cells to be treated such that a voltage pulse, or the current produced thereby, flows through the cells without the majority flowing away over the cells unused in the electrolyte. The invention further relates to a method for applying at least one electric field to adherent cells, in which the electric field is generated by applying a voltage to at least two electrodes, the electric field is concentrated on the side of the electrodes which faces the cells and/or is limited to the space between the cells and the side of the electrodes which faces the cells. 1. Electrode arrangement comprisingat least two electrodes which each include at least one area being disposed face to face with the corresponding area of the respective other electrode, wherein an electrically isolating material is at least partially disposed between the areas of the electrodes.2. The electrode arrangement according to claim 1 , wherein at least three electrodes are provided.3. The electrode arrangement according to claim 1 , wherein the electrodes are formed like a plate or pin.4. The electrode arrangement according to claim 1 , wherein the areas are lateral surfaces of electrode plates that are disposed coplanar.5. The electrode arrangement according to claim 1 , wherein the areas are completely separated from each other by the isolating material.6. The electrode arrangement according to claim 1 , wherein the space between the electrodes defined by the areas of the electrodes is completely filled by the isolating ...

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Номер записи: 32
03-10-2013 дата публикации

ELECTROPORATION-INDUCED ELECTROSENSITIZATION

Номер: US20130260435A1
Автор: Pakhomov Andrei G., Pakhomova Olga
Принадлежит: Old Dominion University Research Foundation

Methods of enhancing membrane permeabilization in a cell are provided. A method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the method, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm. 1. A method of enhancing membrane permeabilization in at least one cell , comprising:(a) disposing the at least one cell between a first electrode and a second electrode; and(b) applying a plurality of electrical pulses between the first electrode and the second electrode,wherein the plurality of electrical pulses comprise at least two trains of pulses separated by an interval, and wherein an amplitude of the electrical pulses is greater than about 0.2 kV/cm.2. The method of claim 1 , wherein a duration of time for the plurality of pulses is between about 10 s and 1000 s.3. The method of claim 1 , wherein the amplitude is between about 0.2 kV/cm and 15 kV/cm.4. The method claim 1 , wherein the plurality of electrical pulses comprises less than about 1500 pulses.5. (canceled)6. (canceled)7. The method of claim 1 , wherein the interval is at least 10 s.8. (canceled)9. The method of claim 1 , wherein the interval is between about 10 s and 30 minutes.10. The method of claim 1 , wherein the at least two trains of pulses comprise a first train of one or more electrical pulses and a second train of one or more electrical pulses.11. The method of claim 10 , wherein the first train and the second train are substantially the same.12. The method of claim 10 , wherein the first train and the second train are different.13. The method of claim 10 , wherein a number of electrical pulses in the first train comprises 25% to 75% of the plurality of electrical pulses.14. (canceled)15. The method of ...

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Номер записи: 33
03-10-2013 дата публикации

MOLECULAR DELIVERY WITH NANOWIRES

Номер: US20130260467A1
Автор: Jorgolli Marsela, Park Hongkun, Robinson Jacob, Shalek Alexander k., Sutton Amy
Принадлежит: President and Fellows of Harvard

A molecular delivery device including a plurality of nanowires (e.g., Si NWs) coated with an electrically conductive layer. Also disclosed are methods for delivering a molecule by nanowire-mediated electroporation. 2. The device of claim 1 , wherein each of the nanowires is attached to the surface along a substantially vertical direction to the surface.3. The device of claim 1 , wherein each of the nanowires is formed of a semiconductor claim 1 , a compound semiconductor claim 1 , a metal oxide claim 1 , a metal claim 1 , carbon claim 1 , boron nitride claim 1 , or a combination thereof.4. The device of claim 3 , wherein the semiconductor is silicon.5. The device of claim 1 , wherein each of the nanowires is 20-10 claim 1 ,000 nm in height and 10-500 nm in diameter.6. The device of claim 5 , wherein the height is 100-5 claim 5 ,000 nm and the diameter is 50-250 nm.7. The device of claim 6 , wherein the height is 800-1 claim 6 ,200 nm and the diameter is 70-180 nm.8. The device of claim 1 , wherein the electrically conductive layer is formed of a metal claim 1 , a metal oxide claim 1 , a semiconductor claim 1 , a compound semicoductor claim 1 , a metal nitride claim 1 , or combination thereof.9. The device of claim 1 , wherein the density of the nanowires is 0.05-10 μm.10. The device of claim 9 , wherein the density is 0.1-5 μm.11. The device of claim 10 , wherein the density is 0.2-2 μm.12. A method of delivering a molecule to a cell claim 10 , the method comprising:providing a substrate having a surface and a plurality of nanowires attached to the surface, wherein both the substrate and nanowires are electrically conductive;contacting the nanowires with the cell to allow penetration of one or more nanowires into the cell, wherein the cell is immersed in a bath solution containing the molecule; andapplying a current or voltage waveform between the substrate and an electrode in the bath solution, whereby the molecule enters into the cell through transiently formed ...

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Номер записи: 34
03-10-2013 дата публикации

Method, Device and System for Targetted Cell Lysis

Номер: US20130261683A1
Автор: Dodgson John Robert, Soikum Soiwisa, Thomsen Lars
Принадлежит: GIANTCODE CORPORATION PTE LTD

A method, device and system employs particles, such as nanoparticles, and an electric or electro-magnetic field, to cause cell death in target cells by non-thermal means. The method of causing targeted cell death comprises the steps of: introducing a particle to the interior of a target cell and exposing the target cell to a transient electromagnetic field for a sufficient time interval in order to cause cell death. The invention overcomes problems associated with similar methods as a result of the fact that a smaller electric field is applied because the particle enhances the effect of the electric field in its immediate vicinity, so reducing the field strength needed to achieve cell lysis and thereby reducing the risk of damage to healthy cells that may be in its vicinity. Apparatus for performing the method; as well as techniques of delivering particles and for producing particles are also described. 1. A method of causing targeted cell death by a non-thermal mechanism comprising:introducing a particle to an interior of a target cell; andexposing said target cell to an electric field for a sufficient time interval to cause cell death.2. A method of causing targeted cell death by a non-thermal mechanism according to claim 1 , wherein:said particle in said target cell, and said electric field, are selected so as to cause irreversible electroporation of said target cell.3. A method of causing targeted cell death by a non-thermal mechanism according to claim 1 , further comprising:adhering a second particle on, or adjacent, an exterior surface of said target cell.4. A method of causing targeted cell death by a non-thermal mechanism claim 1 , comprising:introducing at least two particles outside a target cell; andexposing said target cell to a transient electromagnetic field for a time interval sufficient to cause cell death;whereby said at least two particles act co-operatively to cause said cell death.5. A method of causing targeted cell death by a non-thermal ...

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Номер записи: 35
10-10-2013 дата публикации

Methods for Culturing Cells in an Alternating Ionic Magnetic Resonance (AIMR) Multiple-Chambered Culture Apparatus

Номер: US20130267003A1
Автор: Goodwin Thomas J., Kushman Moses J.
Принадлежит:

Provided herein are methods for culturing cells, tissues or organoid bodies in the presence of a pulsating alternating ionic magnetic resonance field and models comprising a tissue-like assembly of the cells so cultured. The cells, tissues or organoid bodies are introduced into a culture unit comprising growth and nutrient modules in which the gravity vector of the growth unit is continually randomized and cultured in the presence of the alternating ionic magnetic resonance field. 1. A method for culturing cells , comprising the steps of:introducing cells into a culture unit having a growth module and a nutrient module;randomizing continually the gravity vector of the growth module; andapplying a pulsating alternating ionic magnetic resonance field to the growth module during culturing of the cells.2. The method of claim 1 , wherein the introducing step comprises:placing the cells into the growth module;filling the growth module with growth media;sealing the growth module to remove observable gases;attaching the growth module to the nutrient module; andadding fresh growth medium to the nutrient module.3. The method of claim 1 , wherein the randomizing step comprises:positioning the nutrient module comprising the culture unit into a randomizing adapter; andrandomizing the gravity vector via a randomizing mechanism comprising the randomizing adapter.4. The method of claim 1 , wherein the applying step comprises:positioning the growth module comprising the culture unit into an electromagnetic chamber; andgenerating the pulsating alternating ionic magnetic resonance field in the electromagnetic chamber.5. The method of claim 1 , further comprising the step of:modulating the alternating ionic magnetic resonance field to produce overlapping or fluctuating alternating ionic magnetic resonance frequencies at one or more modal intervals spanning about 6.5 Hz and ranging from about 7.8 Hz to about 59.9 Hz.6. The culture system of claim 5 , wherein the overlapping or ...

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Номер записи: 36
10-10-2013 дата публикации

Alternating Ionic Magnetic Resonance (AIMR) Multiple-Chambered Culture Apparatus

Номер: US20130267020A1
Автор: Goodwin Thomas J., Kushman Moses J.
Принадлежит:

Provided herein are a culture apparatus, culture systems and an alternating ionic magnetic resonance electromagnetic chamber for culturing cells, tissues or organoid bodies or for delivering a pulsating alternating ionic magnetic resonance field to an object of interest including the above or to an animal, human or plant. The culture apparatus comprises a culture unit having growth and nutrient modules and a randomizing adapter to continually randomize the gravity vector in the growth module. The culture systems further comprise the alternating ionic magnetic resonance electromagnetic chamber. 1. A culture apparatus for growing cells , comprising:means for containing the cells in a growth environment; andmeans for continually randomizing the gravity vector in the growth environment.2. The culture apparatus of claim 1 , wherein the means for containing the cells is a culture unit comprising a nutrient module and growth module in fluid contact claim 1 , said cells contained within the growth module.3. The culture apparatus of claim 2 , wherein the nutrient module comprises:an open-ended body having a proximal end with a diameter of a length to receive the growth module therein; anda distal end comprising a first sealable opening.4. The culture apparatus of claim 3 , wherein the proximal end of the nutrient module comprises a first gas-permeable membrane with a gas port disposed thereon.5. The culture apparatus of claim 2 , wherein the growth module comprises:a body having a proximal end comprising a second gas-permeable membrane with a plurality of inlet/outlet ports disposed thereon; anda distal end comprising a baffling system and a semi-permeable membrane in fluid contact with the first gas-permeable membrane.6. The culture apparatus of claim 2 , wherein the means for continually randomizing the gravity vector in the growth environment comprises a randomizing adapter having an open proximal end of a diameter sufficient in length to receive the culture unit therein ...

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Номер записи: 37
17-10-2013 дата публикации

COMPOSITIONS AND METHODS FOR CONTINUOUS HARVESTING OF SUSPENSION GROWTH CULTURES

Номер: US20130273630A1
Автор: CROWELL Richard, ZHANG Tianxi
Принадлежит: SOLIX BIOFUELS, INC

Embodiments herein concern compositions, methods and uses for harvesting suspension cultures or decontaminating waters. In certain embodiments, suspension microorganism cultures can comprise algal cultures. In some embodiments, harvesting suspension cultures may include using a composition capable of interacting with the culture in order to separate the culture from a liquid or media. 1. A method for harvesting a suspension of an organism in a liquid , comprising:adding a magnesium agent to the suspension to produce a flocculant comprising the organism and the magnesium agent;separating the flocculant from the liquid; andharvesting the organism.2. The method of claim 1 , wherein the flocculant is produced at a pH about 9.0 to pH about 11.5.3. The method of claim 1 , wherein the magnesium agent is a positively-charged agent comprising a magnesium hydroxide.4. The method of claim 1 , wherein the separating step comprises adding a negatively charged magnetic particle and exposing the flocculant to a magnetic field.5. The method of claim 1 , wherein harvesting the organism occurs after the flocculant is exposed to a reduced pH of about 6.0 to about 7.5.6. The method of claim 1 , further comprising:adding a negatively charged non-magnetic material to the suspension to produce a complex comprising the flocculant and the negatively charged non-magnetic material; andallowing the complex to settle out of the suspension.7. The method of claim 6 , wherein the negatively charged non-magnetic material is selected from silica claim 6 , tungsten claim 6 , aluminum claim 6 , aluminum hydroxides claim 6 , copper claim 6 , allay claim 6 , rare earth materials claim 6 , ceramic materials claim 6 , clay claim 6 , glass claim 6 , calcium claim 6 , and carbon claim 6 , organic materials and composite materials.8. The method of claim 6 , wherein the negatively charged non-magnetic material has a particle size of 0.5 μm to 10 μm.9. The method of claim 6 , further comprising harvesting the ...

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Номер записи: 38
24-10-2013 дата публикации

ROTARY/PUSH OPERATING DEVICE FOR A MAN-MACHINE INTERFACE

Номер: US20130276572A1
Автор: Vogt Frank
Принадлежит:

A rotary/push operating device () for a man-machine interface, in particular for an operating unit of a vehicle, comprises a manually operable rotary/push element () which can be rotated about a rotational axis () and which can be pushed down in the direction of the rotational axis (), and a rolling-body bearing () which defines the rotational axis () and which comprises a immobile bearing ring (), a movable bearing ring (), and a rolling-body cage () arranged between said bearing rings. The rotary/push element () is coupled to the movable bearing ring () in such a manner that the rotary/push element () will move together with the movable bearing ring () when, during rotation of the rotary/push element (), the movable bearing ring () rotates or is axially moved in the direction of the rotational axis (). 1. A rotary/push operating device for a man-machine interface , in particular for an operating unit of a vehicle , comprisinga manually operable rotary/push element which can be rotated about a rotational axis and which can be pushed down in the direction of the rotational axis,a rolling-body bearing defining the rotational axis, said rolling-body bearing comprising a immobile bearing ring, a movable bearing ring, and a rolling-body cage arranged between said bearing rings,the rotary/push element being tightly coupled to the movable bearing Ring,the rolling-body cage comprising a plurality of rolling bodies arranged in at least one radial plane of the rolling-body cage, andthe immobile bearing ring and the movable bearing ring forming at least one circular moving channel which the rolling bodies, upon rotation of the rotary/push element, are movable in the circumferential direction of the two bearing rings with rolling movements on opposite moving tracks of the two bearing rings, and, when the rotary/push element is being pushed, are movable in the direction of the rotational axis on the moving tracks at a right angle relative to said circumferential direction, ...

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Номер записи: 39
31-10-2013 дата публикации

Latching Apparatus And An Operating Mechanism With Such A Latching Apparatus

Номер: US20130285771A1
Автор: LADUFJÄLL Erik, Staffas Daniel
Принадлежит:

A latching apparatus for an operating mechanism for an electrical switching apparatus includes a first member movable between a first position and a second position, in the first position the first member adapted to lock a drive member of the operating mechanism and a force of the drive member applied to the first member, and in the second position the first member is adapted to release the drive member from the locked position. Guiding means guides the movement of the first member. A trip member is movable between a third position and a fourth position, in the third position the trip member adapted to lock the first member, and in the fourth position the trip member is adapted to release the first member. The guiding means are adapted to guide at least a first portion of the first member in a first direction toward a counter roller 1. A latching apparatus for an operating mechanism for an electrical switching apparatus , the operating mechanism being operatively connectable to the switching apparatus , the latching apparatus comprisinga first member movable between at least one first position and at least one second position, in the first position the first member being adapted to lock a drive member of the operating mechanism in a locked position and a force of the drive member being applied to the first member, and in the second position the first member is adapted to release the drive member from the locked position,a counter roller defining a first axis, at least in the first position the first member being adapted to bear against the counter roller,guiding means for guiding the movement of the first member, the guiding means being adapted to guide the movement of the first member in relation to the counter roller, anda trip member movable between at least one third position and at least one fourth position, in the third position the trip member being adapted to lock the first member in the first position, and in the fourth position the trip member is adapted ...

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Номер записи: 40
31-10-2013 дата публикации

Variable Speed Toggle Trigger

Номер: US20130285789A1
Автор: Brehm James R., Happ Kenneth C., Pusateri Daniel
Принадлежит:

A variable speed toggle switch that allows a user to reverse a rotational direction of a motor and supply variable amounts of power to a motor, such as in a power tool, for example, a power drill. A trigger can include a gear segment that meshingly engages a gear on a potentiometer to electrically communicate the actuation direction and actuation amount of the trigger to a microprocessor. The microprocessor can then signal to an H-bridge, or to a series of transistors, the actuation direction and actuation amount of the trigger. A motor or other device can be powered by a power source in an amount corresponding to the actuation amount, and in a direction corresponding to the actuation direction of the trigger. 1. A toggle switch comprising:a trigger pivotable from a neutral position to first and second positions;a potentiometer coupled to the trigger and adapted to generate a trigger signal indicating an amount and direction of pivotal movement of the trigger relative to the neutral position;a microprocessor coupled to the potentiometer and adapted to receive the trigger signal and control an amount of power provided by a power supply based on the trigger signal.2. The toggle switch of claim 1 , further comprising a motor adapted to receive the amount of power from the power supply.3. The toggle switch of claim 1 , further comprising an H-bridge having first claim 1 , second claim 1 , third and fourth transistors selectively coupled to the power source and the microprocessor.4. The toggle switch of claim 3 , wherein the first and second transistors are p-channel metal oxide semiconductor field effect transistors (MOSFET) claim 3 , and the third and fourth transistors are n-channel MOSFET claim 3 , and the microprocessor is further adapted to selectively close one of the first and second transistors and selectively modulate one of the third and fourth transistors to vary the amount of power.5. The toggle switch of claim 1 , further comprising a first gear coupled to ...

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Номер записи: 41
31-10-2013 дата публикации

Producing Algae Biomass Having Reduced Concentration Of Contaminants

Номер: US20130288329A1
Автор: Eckelberry Nicholas, Sanchez Jose
Принадлежит:

The present invention is generally directed to a system for producing an algae biomass and wastewater that have reduced concentrations of contaminants. The algae and wastewater treated by the system of the present invention can be combined in a heterotrophic growth system in which the growth of the algae is increased due to the reduced concentration of contaminants. The algae grown in this manner also has a longer shelf life due to the lack of contaminants within the harvested algae. 1. A method for producing an algae biomass and wastewater having a reduced concentration of contaminants for use in a heterotrophic growth system , the method comprising:supplying a growth medium containing suspended algae into a first flocculation tank, the first flocculation tank comprising a reactor tube for creating an electric field within the growth medium, the electric field causing the algae to flocculate;transferring the growth medium containing flocculated algae into a first flotation tank, the first flotation tank comprising a tank containing a plurality of electrodes which cause the formation of gas bubbles which attach to the flocculated algae and lift the flocculated algae to the surface of the growth medium;removing the floating algae from the surface of the growth media and transferring the removed algae to a heterotrophic growth system;supplying wastewater into a second flocculation tank, the second flocculation tank comprising a second reactor tube for creating an electric field within the wastewater, the second reactor tube including a cathode and an anode, the anode comprising a titanium ruthenium alloy, wherein when the electric field is created, the anode causes the creation of free chlorine within the fluid leading to the oxidation of the ammonia into nitrite and nitrate;after the ammonia is oxidized, transferring the wastewater to the heterotrophic growth system such that the wastewater can act as a food for the growth of the algae in the heterotrophic growth ...

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Номер записи: 42
14-11-2013 дата публикации

PRODUCTION OF CELL TISSUE HAVING THREE-DIMENSIONAL STRUCTURE USING ELECTROSTATIC INK JET PHENOMENON

Номер: US20130302872A1
Автор: ITO Yoshihiro, KATAHIRA Kazutoshi, KITAJIMA Takashi, Ohmori Hitoshi, UMEZU Shinjiro
Принадлежит: RIKEN

A method and an apparatus for producing a cell tissue of blood vessels or the like with the use of an electrostatic ink jet phenomenon are provided. A pattern generator for cell tissue patterning on a substrate includes at least one vessel for holding a solution containing materials used for cell tissue formation, a substrate that is an object of patterning, and a pattern generator including a voltage applying unit for applying a voltage to the vessel. The voltage is applied to the vessel by the voltage applying unit to generate an electric field between the vessel and the substrate, causing the solution to be ejected from the vessel as a result of an electrostatic ink jet phenomenon and allowing the ejected solution to adhere to the substrate. 1. A method for producing a cell tissue having a three-dimensional structure in which cells remain alive by patterning a cell tissue on a substrate using the pattern generator for cell tissue patterning on the substrate using an electrostatic ink jet system , which comprisesat least one vessel for holding a solution containing materials used for cell tissue formation,a substrate that is an object of patterning,a voltage applying unit for applying a voltage to the vessel, anda plate electrode that is positioned between the vessel and the substrate, grounded, and perforated, the method comprising:ejecting scaffolds and cells onto the substrate so as to allow the scaffolds and the cells to adhere to the substrate for patterning while allowing the cells to come into contact with the scaffolds; andapplying a voltage of 0.5 kv to 5 kv between the vessel and the plate electrode by the voltage applying unit in order to generate an electric field between the vessel and the plate electrode, causing the solution to be ejected from the vessel as a result of an electrostatic ink jet phenomenon and allowing the ejected solution to pass through a hole formed in the plate electrode and adhere to the substrate,wherein a cell tissue is ...

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Номер записи: 43
21-11-2013 дата публикации

ROTARY SWITCH WITH PUSH FUNCTION

Номер: US20130306447A1
Автор: POLAK Andrzej
Принадлежит:

A switch assembly that includes the coaxial assembly of a cylindrical core extending from a base to a distal end, an outer knob rotatable about the core, a switching means generating an electrical signal dependent on the rotations of the knob, and a guiding means for guiding the knob in its motions relative to the core. The guiding means includes an upper-guide in the vicinity of the core-end and the knob-top, and a lower-guide in the vicinity of the core-base and the knob-base. The upper-guide includes elements rolling between an upper-guide inner race integral to the core and an upper-guide outer race integral to the knob. 1. A switch assembly formed by a coaxial assembly along a longitudinal axis of the switch , said switch comprising:a cylindrical core axially extending from a core-base to a distal end, wherein the core-base is fixed to a base plate;a knob extending from a knob-base to a distal knob-top, wherein the knob is axially rotatable about the cylindrical core;a switching means for generating an electrical signal dependent on the rotations of the knob; anda guide means for guiding the knob in its motions relative to the core, said guide means comprising an upper-guide, in the vicinity of the core-end and the knob-top, and a lower-guide in the vicinity of the core-base and the knob-base, whereinthe upper-guide comprises rolling elements, said rolling elements configured to roll between an upper-guide inner race integral to the core, and an upper-guide outer race integral to the knob.2. The switch assembly set forth in claim 1 , wherein the outer race is truncated with upward apex claim 1 , and wherein the switch assembly further comprises an upward bias means for generating an upward axial force biasing the rolling elements onto the upper-guide outer race.3. The switch assembly set forth in claim 1 , wherein the lower-guide comprises rolling elements rolling between a lower-guide inner race integral to the core and a lower-guide outer race integral to the ...

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Номер записи: 44
21-11-2013 дата публикации

SELECTIVE 3D BIOPATTERNING

Номер: US20130309706A1
Автор: Kruglick Ezekiel
Принадлежит: EMPIRE TECHNOLOGY DEVELOPMENT LLC

Methods, systems, and articles for selective three dimensional (3D) biopatterning are disclosed. A biological target may be imaged and a selected area of the image may define a desired pattern for guiding the emission of EM radiation into the biological target. Two or more groups of photosensitive elements responsive to different activation wavelengths may be provided. The photosensitive elements may be selectively activated on or within the biological target based on location and activation wavelength in order to guide cell differentiation, adhesion of growth factors to a scaffold, release of growth factors, and/or deletion of cells. 1. A method for biopatterning a biological target , the method including:selecting a radiation pattern to be applied to an area of the biological target, the radiation pattern defining at least one shape;adding a first group of photosensitive elements to the biological target, the first group responsive to at least a first activation wavelength;radiating a first light into the area of the biological target in a first shape, the first light including at least the first activation wavelength, and the first shape based at least partially on the selected radiation pattern; andradiating at least a second light into the biological target in a second shape, the second light including the first activation wavelength, the second shape based at least partially on the selected radiation pattern, and the first and second lights defining an intersection within the selected area of the biological target, the intersection having a contour corresponding to the at least one shape,wherein a first one or more of the photosensitive elements are located within the intersection and are activated by the first and second lights, andwherein a second one or more of the photosensitive elements are not located within the intersection and are not activated by the first and second lights.2. (canceled)3. The method of claim 1 , further including:selecting, from an ...

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Номер записи: 45
28-11-2013 дата публикации

ANTI-APOPTOSIS OR ANTI-NECROSIS INDUCTION METHOD

Номер: US20130316429A1
Автор: Godal Tomoyuki, Kodama Shohta
Принадлежит:

Disclosed herein is a method for simply inducing an anti-apoptotic effect and/or an anti-necrotic effect in a living cell with good control without administering any drug. The method includes applying an alternating-current voltage to the living cell so that an electric current of 25 μA or higher but 75 μA or lower flows to induce an anti-apoptotic effect and/or an anti-necrotic effect in the living cell. The living cell used may be a cultured cell. The alternating-current voltage may be applied to a stage member on which a container holding the living cell is placed. 1. A method for inducing anti-apoptosis and/or anti-necrosis in a living cell , comprising applying an alternating-current voltage to the living cell so that an electric current of 25 μA or higher but 75 μA or lower flows.2. The method according to claim 1 , wherein the living cell is a cultured cell.3. The method according to claim 1 , wherein the voltage value of the alternating-current voltage is 10 V or higher but 5 kV or lower.4. The method according to claim 2 , wherein the voltage value of the alternating-current voltage is 10 V or higher but 5 kV or lower.5. The method according to claim 1 , wherein the alternating-current voltage is applied to a stage member on which a container holding the living cell is placed. The present invention relates to a method for inducing an anti-apoptotic effect and/or an anti-necrotic effect in a living cell.A technique to suppress the oxidation of coffee or to maintain the freshness of vegetables is conventionally known in which an alternating-current voltage of 10 V or higher but 5 kV or lower is applied to an object to be treated so that an extremely weak electric current of 1 μA or higher but 1000 mA or lower flows (see Patent Documents 1 and 2). However, the mechanism remains unclear by which the oxidation of food can be suppressed or the freshness of food can be maintained by an extremely weak electric current.Meanwhile, apoptosis is one mode of death of ...

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Номер записи: 46
26-12-2013 дата публикации

ELECTRICALLY TRIMMABLE RESISTOR DEVICE AND TRIMMING METHOD THEREOF

Номер: US20130342264A1
Автор: Privitera Stefania Maria Serena, Santangelo Antonello
Принадлежит:

An integrated circuit has a circuit part and a trimmable resistor, the resistance whereof may be modified by Joule effect. The trimmable resistor has first and second connection terminals coupled to the circuit part, and an intermediate terminal that divides the trimmable resistor into two portions. The first and the second connection terminals and the intermediate terminal are coupled to respective pads configured to receive electrical quantities designed to cause, in use, a respective trimming current flow in each portion. In this way, a substantially zero voltage drop is maintained between the first and second connection terminals while current is flowing in the resistor to change an electrical characteristic of the resistor, such as resistance or thermal coefficient. 1. A circuit , comprising:a circuit part;first and second connection pads; and first and second connection terminals electrically coupled to the circuit part, at least one of the first and second connection terminals being configured to be electrically coupled in a trimming phase to the first connection pad;', 'an intermediate terminal electrically coupled to the second connection pad;', 'first and second resistor portions, the first resistor portion positioned between the first connection terminal and the intermediate terminal and the second resistor portion positioned between the first connection terminal and the intermediate terminal, the connection pads being configured to receive a substantially zero voltage drop between the first and the second connection terminals and the intermediate pad being configured to receive an electrical quantity able to generate in the first and second resistor portions respective trimming current flows that modify an electric characteristic of the trimmable resistor and both enter, or both exit, the intermediate terminal., 'a trimmable resistor trimmable by Joule effect, the trimmable resistor having2. The circuit of claim 1 , comprising a trimming circuit having: ...

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Номер записи: 47
26-12-2013 дата публикации

DEVICE AND METHOD FOR CONTROLLING NERVE GROWTH

Номер: US20130344559A1
Автор: Engeberg Erik Daniel, Willits Rebecca Kuntz
Принадлежит: THE UNIVERSITY OF AKRON

A nerve growth chamber includes a stimulation vessel defined by one or more sidewalls; at least one anode and at least one cathode positioned in the sidewall or sidewalls of the stimulation vessel; a conductive medium in the stimulation vessel; nerve tissue in the stimulation vessel; and a signal generator connecting the at least one anode and the at least one cathode and activated to generate a periodic AC signal at a desired frequency and amplitude, the periodic AC signal traveling through the conductive medium and affecting the growth of the nerve tissue. A method in accordance with the operation of the apparatus is also provided. 1. An apparatus for controlling the growth of nerve tissue , the apparatus comprising:a. a stimulation vessel defined by one or more sidewalls;b. at least one anode and at least one cathode positioned in said one or more sidewalls;c. a conductive medium in said vessel;d. nerve tissue in said vessel; ande. a signal generator connecting said at least one anode and said at least one cathode and activated to generate a periodic AC signal at a desired frequency and amplitude, said periodic AC signal traveling through said conductive medium and affecting the growth of said nerve tissue.2. The apparatus of claim 1 , wherein the conductive medium is phosphate buffer saline.3. The apparatus of claim 1 , further comprising nerve growth factor in said stimulation vessel.4. The apparatus of claim 1 , further comprising a plurality of stimulation vessels.5. The apparatus of claim 4 , wherein said plurality of stimulation vessels are controlled by said signal generator.6. The apparatus of claim 1 , further comprising a ceiling relative to said one or more sidewalls claim 1 , and at least one of an anode or cathode in said ceiling and connected to said signal generator.7. The apparatus of claim 6 , further comprising a floor relative to said one or more sidewalls claim 6 , and at least one of an anode or cathode in said ceiling and connected to said ...

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Номер записи: 48
26-12-2013 дата публикации

Method for localized photo-irradiation of biological tissues to stimulate tissue regeneration or repair

Номер: US20130344560A1
Автор: Fox Sherry, Weston Jon
Принадлежит:

This invention relates to a method of delivering light energy to biological tissues for the acceleration of healing of damaged or diseased tissues or regeneration of such tissues. More particularly, the present invention relates to applying various wavelengths of light to articular and non-articular joints, alone, or in conjunction with techniques for restoring or regenerating cartilage, ligament and/or tendons whether in-vitro, in-situ or in-vivo. The present invention also extends to application of photo-irradiation to stimulate enhanced proliferation and site-dependent differentiation of stem cells into mature cells and to stimulate full functioning of mature cells involved in tissue repairs for regeneration of tendons, ligaments, cartilage, bone or muscle, depending on the type of tissue with which the stem cells come into contact. 1. A method for stimulating biological regeneration and tissue repair with photo-irradiation whereby light energy in discrete wavelengths , both visible and invisible , is used to stimulate growth and full function of mature cells and to stimulate site dependent differentiation , proliferation and full function of immature cells.2. A method as defined in to stimulate native dwelling progenitor stem cells found in the surface layers of cartilage to engraft in cartilage lesions as a tissue type normally found in that location of the joint.3. A method as defined in to stimulate transplanted stem cells (autologous or allogeneic) in a cartilage lesion to proliferate claim 1 , site-dependently differentiate into the normal local tissue type claim 1 , and to fully function upon reaching cell maturity.4. A method as defined in to stimulate transplanted chondrocytes (autologous or allogeneic) in a cartilage lesion to proliferate claim 1 , site-dependently differentiate into the normal local tissue type claim 1 , and/or to fully function upon reaching cell maturity.5. A method as defined in to stimulate transplanted cartilage cylinders ( ...

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Номер записи: 49
02-01-2014 дата публикации

MICROBES, METHODS, AND DEVICES FOR REDOX-IMBALANCED METABOLISM

Номер: US20140004578A1
Автор: Bond Daniel R., Flynn Jeffrey M., Gralnick Jeffrey A., Ross Daniel E.
Принадлежит:

The invention generally relates to methods, devices, and microbes involved in performing redox imbalanced fermentations. In one aspect, the invention provides a device that generally includes an electrode and at least one microbe in electron communication with the electrode. The microbe generally can exhibit increased activity of at least one enzyme involved in converting a substrate to a redox imbalanced product. In another aspect, the invention provides a method for performing redox imbalanced fermentation. Generally, the method includes providing a substrate to a microbe under conditions effective for the microbe to metabolize the substrate to a redox imbalanced product. At least one microbe may be in contact with an electrode. In some cases, metabolic conversion of the substrate to the redox imbalanced product can include transferring electrons between the electrode and the microbe. In other cases, metabolic conversion of the substrate to the redox imbalanced product exhibits a carbon flux from organic substrate to organic product of at least 80%. In another aspect, the invention provides a genetically modified microbe. 1. A device comprising:an electrode; andat least one microbe in electron communication with the electrode and genetically modified to exhibit increased activity, compared to a wild-type control, of at least one enzyme that catalyzes a metabolic step converting a substrate to a redox-imbalanced pathway product.2. The device of wherein the microbe comprises an electron flux microbe.3. A device comprising:an electrode; andat least one microbe in electron communication with the electrode and genetically modified to exhibit increased activity, compared to a wild-type control, of at least one enzyme that catalyzes electron flux across the microbe's outer membrane.4. The device of wherein the microbe comprises at least one heterologous coding sequence derived from an electron flux microbe.5Geobacter, Pelobacter, Desulfuromonas, Desulfuromusa, ...

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Номер записи: 50
09-01-2014 дата публикации

METHANOTHERMOBACTER THERMAUTOTROPHICUS STRAIN AND VARIANTS THEREOF

Номер: US20140011251A1
Автор: Mets Laurens
Принадлежит: The University of Chicago

The invention provides an isolated microorganism that is (a) a microorganism of strain UC 120910, deposited on Dec. 21, 2010, with the American Type Culture Collection (ATCC) under ATCC® Patent Deposit Designation No. PTA-11561, (b) a variant thereof, or (c) a progeny thereof, as further described herein. 111.-. (canceled)12Methanothermobacter. An isolated microorganism that produces at least or about 96 molecules of methane per 100 molecules of carbon dioxide supplied to the microorganism or produces at least or about 17 grams of methane from COper gram of cellular material produced from CO.1376.-. (canceled)77Methanothermobacter. An isolated microorganism that:{'sub': 2', '2, 'a. exhibits a methane production efficiency that is at least or about 25 COmolecules converted to methane per COmolecule converted to cellular material; or'}b. survives in a stationary phase with a doubling time of at least or about 72 hours; orc. exhibits a cell culture density of at least or about 6 mg dry mass of cells/ml culture in a stationary phase; ord. returns to at least 80% of the methane productivity level in the operating state within 20 minutes, after an exposure of at least or about 3 minutes to oxygen or carbon monoxide.7884.-. (canceled)85Methanothermobacter. An isolated microorganism that is{'i': 'Methanothermobacter thermautotrophicus', '(a) a microorganism of strain UC 120910, deposited on Dec. 21, 2010, with the American Type Culture Collection (ATCC®) under ATCC® Patent Deposit Designation No. PTA-11561,'}(b) a variant of (a), or(c) a progeny of (a),{'sub': '2', 'wherein the variant or progeny retains the COconversion phenotypic characteristics of (a).'}86MethanothermobacterMethanothermobacter thermautotrophicus. The isolated microorganism of claim 85 , wherein the variant or progeny expresses a 16S rRNA that has at least 90% sequence identity to the full length of the sequence of 16S rRNA of Delta H (SEQ ID NO: 1).87. (canceled)88. (canceled)89Methanothermobacter. The ...

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Номер записи: 51
16-01-2014 дата публикации

OPERATOR CONTROL ELEMENT AND DOMESTIC APPLIANCE

Номер: US20140013897A1
Автор: Clauss Stéphane, Oberhomburg Martin
Принадлежит: BSH BOSCH UND SIEMENS HAUSGERÄTE GMBH

An operating element for a domestic appliance includes a main body which is made of a material comprised of plastic and a filler admixed to the plastic. The filler has a thermal conductivity which is higher than a thermal conductivity of the plastic. The filler can be present in particle form, e.g. as spheres, grains, fibers or as powder. 112-. (canceled)13. An operating element for a domestic appliance , said operating element comprising a main body made of a material comprised of plastic and a filler admixed to the plastic , said filler having a thermal conductivity which is higher than a thermal conductivity of the plastic.14. The operating element of claim 13 , wherein the filler is present in particle form.15. The operating element of claim 13 , wherein the filler is present as spheres claim 13 , grains claim 13 , fibers or as powder.16. The operating element of claim 13 , wherein the filler comprises at least one material selected from the group consisting of metal filler claim 13 , ceramic filler claim 13 , glass filler claim 13 , and carbon filler.17. The operating element of claim 16 , wherein the metal filler includes powdered copper claim 16 , aluminum or stainless steel.18. The operating element of claim 13 , wherein the material of the main body has a thermal conductivity of 1 to 20 W/mK.19. The operating element of claim 13 , wherein the filler is present in the material of the main body at a proportion by volume which is less than 70%.20. The operating element of claim 13 , wherein the filler is present in the material of the main body at a proportion by volume which is less than 50%.21. The operating element of claim 13 , wherein the plastic of the main body comprises a technical polymer.22. The operating element of claim 21 , wherein the technical polymer is polyamide.23. The operating element of claim 13 , further comprising a coating applied upon the main body.24. The operating element of claim 23 , wherein the coating is a metal coating.25. The ...

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Номер записи: 52
16-01-2014 дата публикации

VARIABLE RESISTER HAVING RESISTANCE VARYING GEOMETRICALLY RATIO AND CONTROL METHOD THEREOF

Номер: US20140015634A1
Автор: Lee Jongwoo
Принадлежит: SAMSUNG ELECTRONICS CO. LTD.

An analog amplifier for amplifying an analog signal and an analog filter is provided. In particular, an apparatus and method for controlling gain and cutoff frequency of the variable gain amplifier and the variable cutoff frequency filter that is capable of changing the gain and cutoff frequency are provided. The variable resister includes a plurality of resister segments in the variable resister and, when a plurality of resistance candidates for the variable resister is arranged in order of size, the resistance candidates form a geometric series. 1. A variable resister comprising:a plurality of resister segments; anda plurality of switches connected to the plurality of resister segments;wherein the plurality of switches control connection states of the plurality of resister segments according to individual bits or combinations of the individual bits of a control signal of N bits, andwherein a resistance of each of the plurality of resister segments is determined according to an exponential function based on the control signal of N bits.2. The variable resister of claim 1 , wherein the resistance of the plurality of resister segments is determined according to a Taylor approximation coefficients of the exponential function based on the control signal of N bits.3. The variable resister of claim 1 , wherein a switch of the plurality of switches is connected in parallel to corresponding resister segments of the plurality of resister segments.4. The variable resister of claim 1 , wherein the plurality of resister segments are connected in series based on the connection states of the plurality of switches.5. The variable resister of claim 1 , wherein the plurality of resister segments comprises a first resister segment and a plurality of second resister segments claim 1 , and the plurality of switches are connected to a corresponding resister segment of the plurality of second resister segments in parallel.6. The variable resister of claim 1 , wherein a total resistance ...

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Номер записи: 53
16-01-2014 дата публикации

SYSTEMS, METHODS AND APPARATUSES FOR AGGREGATING AND HARVESTING MICROORGANISMS FROM AN AQUEOUS SUSPENSION

Номер: US20140017754A1
Автор: Kale Aniket, KNIEP Justin S.
Принадлежит: Heliae Development, LLC

Described herein are systems, methods, and apparatuses for aggregating microorganism in an aqueous suspension. In particular, are systems, methods, and apparatuses that apply an electrical field and/or acoustic energy to an aqueous suspension comprising microorganisms as the aqueous suspension follows a flow path to cause aggregation of the microorganisms. The electrical field may be continuous or pulsed. In some embodiments, the flow path for the aqueous suspension may vary. In some embodiments, the cross-sectional area of the electrical field may be tuned. 1. An apparatus for aggregating microorganisms in an aqueous suspension , comprising:a. at least one cathode;b. at least one anode, disposed opposite the at least one cathode;c. at least one pair of spaced insulators disposed between the at least one cathode and the at least one anode; wherein the channel has a length commensurate with the lengths of the at least one cathode and the at least one anode,', 'wherein the channel defines a fluid flow path,', 'wherein the channel comprises a cross-section comprising a height and a width, and wherein at least one of the height and the width of the cross-section varies over a length of the channel;, 'd. a channel defined between the at least one cathode, the at least one anode, and the at least one pair of spaced insulators,'}e. an electrical power source operably connected to the at least one cathode and the at least one anode, wherein an electrical field is created by applying an electric current from the electrical power source to the at least one cathode and the at least one anode; andf. a separation tank in fluid communication downstream of the channel, wherein the separation tank is configured to collect fluid flow from the fluid flow path defined by the channel.2. The apparatus of claim 1 , wherein at least one of the height and the width of the cross-section increases over the length of the fluid flow path.3. The apparatus of claim 1 , wherein at least one of ...

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Номер записи: 54
16-01-2014 дата публикации

AGGREGATING MICROORGANISMS WITH ELECTRICAL AND ACOUSTIC ENERGY

Номер: US20140017755A1
Автор: Kale Aniket, KNIEP Justin S.
Принадлежит:

Described herein are systems, methods, and apparatuses for aggregating microorganism in an aqueous suspension. In particular, are systems, methods, and apparatuses that apply an electrical field and acoustic energy to an aqueous suspension comprising microorganisms as the aqueous suspension follows a flow path to cause aggregation of the microorganisms. The electrical field may be continuous or pulsed. In some embodiments, the flow path for the aqueous suspension may vary. 1. A system for aggregating microorganisms in an aqueous suspension , comprising: i. at least one first electrical conductor;', 'wherein the at least one first electrical conductor is disposed within the at least one second electrical conductor, such that a channel is defined between an exterior surface of the at least one first electrical conductor and an interior surface of the at least one second electrical conductor and with a cross-section comprising a diameter, the channel providing a fluid flow path for the aqueous suspension;', 'ii. at least one second electrical conductor;'}, 'iii. an electrical power source operably connected to the at least one first electrical conductor and the at least one second electrical conductor, wherein electrical field is created when an electric current is provided from the electrical power source to the at least one first electrical conductor and the at least one second electrical conductor and the aqueous suspension;, 'a. a device configured to apply an electric field to an aqueous suspension, comprising i. a tube configured to contain a flow of the aqueous suspension;', 'ii. at least one transducer coupled to the tube;', wherein the generator transmits an electrical radio frequency signal to the transducer and the transducer converts the electrical signal into an acoustic signal which vibrates the tube and creates a wave with a pressure minima node at a location within the tube;', 'wherein the device configured to apply an electrical field and the device ...

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Номер записи: 55
16-01-2014 дата публикации

ELECTRICAL MICROORGANISM AGGREGATION METHODS

Номер: US20140017756A1
Автор: Kale Aniket, KNIEP Justin S.
Принадлежит:

Described herein are systems, methods, and apparatuses for aggregating microorganism in an aqueous suspension. In particular, are systems, methods, and apparatuses that apply an electrical field to an aqueous suspension comprising microorganisms as the aqueous suspension follows a flow path to cause aggregation of the microorganisms. The electrical field may be continuous or pulsed. In some embodiments, the flow path for the aqueous suspension may vary. 1. A method for aggregating microorganisms in an aqueous suspension , comprising: i. at least one electrical conductor comprising a conductive material configured as a cathode;', 'ii. at least one second electrical conductor comprising a conductive material configured as an anode, wherein the at least one electrical conductor comprising a conductive material configured as a cathode is disposed opposite the at least one second electrical conductor comprising a conductive material configured as an anode;', 'iii. at least one pair of spaced insulators disposed between the at least one electrical conductor comprising a conductive material configured as a cathode and the at least one electrical conductor comprising a conductive material configured as an anode;', 'wherein the channel defines a fluid flow path for the aqueous suspension, and wherein the fluid flow path comprising at least one of a height, a width, and a diameter which varies along at least a portion of a length of the fluid flow path; and', 'iv. a channel defined between the at least one electrical conductor comprising a conductive material configured as a cathode, the at least one electrical conductor comprising a conductive material configured as an anode, and the pair of at least one pair of insulators, wherein the channel has a length commensurate with the lengths of the at least one cathode and the at least one electrical conductor comprising a conductive material configured as an anode,'}, 'wherein at least one aggregating apparatus differs from at ...

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Номер записи: 56
16-01-2014 дата публикации

PATTERNED ELECTRICAL PULSE MICROORGANISM AGGREGATION

Номер: US20140017757A1
Автор: Kale Aniket, KNIEP Justin S.
Принадлежит:

Described herein are systems, methods, and apparatuses for aggregating microorganism in an aqueous suspension. In particular, are systems, methods, and apparatuses that apply an electrical field to an aqueous suspension comprising microorganisms as the aqueous suspension follows a flow path to cause aggregation of the microorganisms. The electrical field may comprise different types of pulses. In some embodiments, the flow path for the aqueous suspension may vary. 1. A method of aggregating microorganisms in an aqueous solution , comprising:a. providing an aqueous solution feed comprising a liquid and microorganisms dispersed therein; and 'i. applying a pulsed electric field to the aqueous suspension, the pulsed electrical field generated by a power source and a pulse generator, wherein said pulse generator produces a pattern of electrical pulses which vary in a pulse type comprising at least one of a pulse amplitude, a pulse duration, a pulse shape, and a pause duration between pulses.', 'b. aggregating the aqueous suspension feed, the aggregating comprising2. The method of claim 1 , wherein the pulse shape is rectangular claim 1 , trapezoidal claim 1 , exponentially decaying claim 1 , unipolar claim 1 , or bipolar.3. The method of claim 1 , wherein the pulse duration ranges from 1 to 1 claim 1 ,000 nanoseconds.4. The method of claim 1 , wherein the pattern of electrical pulses alternates more than one pulse types.5. The method of claim 1 , further comprising adding a chemical aggregating agent to the aqueous solution feed.6. The method of claim 1 , wherein the pattern of electrical pulses utilized by the pulse generator comprises a programmed pattern.7. The method of claim 6 , wherein the programmed pattern is selected by a computerized controller based on at least one of a measured turbidity of the aqueous solution claim 6 , a measured density of the aqueous solution claim 6 , a composition of the aqueous solution claim 6 , and a flow rate of the aqueous solution ...

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Номер записи: 57
16-01-2014 дата публикации

TUBULAR ELECTRO-ACOUSTIC AGGREGATION DEVICE

Номер: US20140017758A1
Автор: Kale Aniket, KNIEP Justin S.
Принадлежит:

Described herein are systems, methods, and apparatuses for aggregating microorganism in an aqueous suspension. In particular, are systems, methods, and apparatuses that apply an electrical field and/or acoustic energy to an aqueous suspension comprising microorganisms as the aqueous suspension follows a flow path to cause aggregation of the microorganisms. The electrical field may be continuous or pulsed. In some embodiments, the flow path for the aqueous suspension may vary. 1. An apparatus for aggregating microorganisms in an aqueous suspension , comprising:a. a tube configured to contain a flow of an aqueous suspension comprising microorganisms;b. an anode disposed within the tube and with a length parallel to a concentric longitudinal axis of the tube;c. a cathode disposed within the tube, and with a length parallel to the anode forming a gap between the anode and cathode comprising the concentric longitudinal axis of the tube;d. an electrical power source operably connected to the anode and the cathode for creating an electrical field by providing an electric current that is applied between the anode and cathode and the aqueous suspension;e. at least one transducer coupled to the tube; andf. a generator configured to produce and transmit radio frequency signals, wherein the generator transmits an electrical radio frequency signal to the transducer and the transducer converts the electrical signal into an acoustic signal which vibrates the tube and creates a standing wave with a pressure minima node at a location between the anode and cathode.2. The apparatus of claim 1 , wherein the electrical field and acoustic standing wave are applied simultaneously to the aqueous suspension.3. The apparatus of claim 1 , further comprising a piezoelectric vibration energy harvester coupled to the tube and configured to convert vibration energy into electrical current.4. The apparatus of claim 1 , wherein the electrical field is pulsed.5. The apparatus of claim 1 , wherein ...

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Номер записи: 58
16-01-2014 дата публикации

TUNABLE ELECTRICAL FIELD FOR AGGREGATING MICROORGANISMS

Номер: US20140017760A1
Автор: Kale Aniket, KNIEP Justin S.
Принадлежит:

Described herein are systems, methods, and apparatuses for aggregating microorganism in an aqueous suspension. In particular, are systems, methods, and apparatuses that apply an electrical field to an aqueous suspension comprising microorganisms as the aqueous suspension follows a flow path to cause aggregation of the microorganisms. The electrical field may be continuous or pulsed. In some embodiments, the flow path for the aqueous suspension may vary. In some embodiments, the cross-sectional area of the electrical field may be tuned. 1. An apparatus for aggregating microorganisms in an aqueous suspension , comprising:a. a vessel configured to contain an aqueous suspension of microorganisms and configured for fluid communication with a housing;b. at least one first electrical conductor configured as a cathode disposed within the housing;c. at least one second electrical conductor configured as an anode disposed within the housing;d. at least one third electrical conductor configured as a collector electrode disposed within the housing and adjacent to the at least one first electrical conductor;e. at least one fourth electrical conductor configured as a control electrode disposed within the housing and adjacent to the at least one first electrical conductor, wherein the at least one first electrical conductor is at least partially surrounded by the at least one second electrical conductor such that a channel is defined between an exterior surface of the at least one first electrical conductor and an interior surface of the at least one second electrical conductor, providing a fluid flow path configured for receiving the aqueous suspension from the vessel; andf. at least one electrical power source operably connected to the at least one first electrical conductor, second electrical conductor, third electrical conductor, and fourth electrical conductor, wherein an electrical field is created by providing an electrical current from the electrical power source to the at ...

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Номер записи: 59
16-01-2014 дата публикации

Combining Biological Micro-Objects

Номер: US20140017791A1
Автор: Chapman Kevin T., Khandros Igor Y., Mathieu Gaetan L., Short Steven W., Wu Ming C.
Принадлежит:

Two or more biological micro-objects can be grouped in a liquid medium in a chamber. Grouping can comprise bringing into and holding in proximity or contact the micro-objects in a group, breaching the membrane of one or more of the micro-objects in a group, subjecting one or more of the micro-objects in a group to electroporation, and/or tethering to each other the micro-objects in a group. The micro-objects in the group can then be combined into a single biological object. 1. A process of combining biological micro-objects , said process comprising:selecting a first biological micro-object and a second biological micro-object from a plurality of micro-objects in a liquid medium in a micro-fluidic device;grouping said first micro-object with said second micro-object in said liquid medium in said micro-fluidic device; andwhile said first micro-object and said second micro-object are grouped, combining said first micro-object and said second micro-object in said liquid medium to produce a combined biological micro-object.2. The process of claim 1 , wherein:said selecting comprises trapping said first micro-object in a first light trap directed into said micro-fluidic device, and trapping said second micro-object in a second light trap directed onto said micro-fluidic device; andsaid grouping comprises merging said first light trap and said second light trap and thereby forming a merged light trap trapping said first micro-object and said second micro-object.3. The process of claim 2 , wherein said combining comprises moving said merged light trap through a combining region of said micro-fluidic device.4. The process of claim 3 , wherein said combining region comprises a chemical that facilitates said combining.5. The process of claim 2 , wherein said combining comprises moving said merged light trap directly between a first electrode and a second electrode to which a power source is connected.6. The process of claim 2 , wherein:said combining comprises moving said ...

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Номер записи: 60
06-02-2014 дата публикации

RAPID CELL PURIFICATION SYSTEMS

Номер: US20140038171A1
Автор: Hance Kenneth Robert, Metzger Steven W.
Принадлежит: Accelerate Technology Corporation

Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface. 1. A method of purifying at least one of cells and viruses in a sample comprising:adding the sample to a well disposed in a medium;applying an electrical potential across the medium to cause contaminants to enter said medium through one or more walls of said well while retaining the at least one of the cells and/or viruses in said well; andremoving the at least one of the cells and viruses from said well.2. The method of claim 1 , wherein said cells are microorganisms.37-. (canceled)8. The method of claim 1 , wherein said medium comprises at least one of a filter or a hydrogel.9. (canceled)10. The method of claim 8 , wherein said hydrogel comprises at least one of a polyacrylamide or agarose.11. The method of claim 1 , comprising placing a buffer in contact with said medium.12. The method of claim 11 , wherein said buffer comprises histidine and tris(hydroxymethyl)aminomethane.13. The method of claim 1 , further comprising immobilizing the at least one of the cells and viruses.14. The method of claim 13 , wherein the at least one the of cells and viruses are immobilized on a positively charged surface.15. The method of any one of claim 1 , further comprising detecting the at least one of the cells and viruses.16. The method of claim 1 , further comprising adding a chemical agent to the sample to increase a permeability of the medium to the ...

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Номер записи: 61
06-02-2014 дата публикации

METHODS OF USING ULTRASOUND IN TISSUE CULTURE AND TISSUE ENGINEERING

Номер: US20140038257A1
Автор: Subramanian Anuradha, TURNER Joseph
Принадлежит:

The present disclosure describes methods of using ultrasound in tissue culture and tissue engineering, as well as a bioreactor that includes at least one ultrasound transducer. 1. A method of culturing cells or tissue , comprising:exposing cells or tissue in culture to intermittent low-intensity-diffuse ultrasound.2. The method of claim 1 , wherein the intermittent low-intensity-diffuse ultrasound comprises a frequency of from about 1 MHz to about 8 MHz.3. The method of claim 2 , wherein the intermittent low-intensity-diffuse ultrasound comprises a pressure of from about 14 kPa to about 60 kPa.4. The method of claim 2 , wherein the intermittent low-density-diffuse ultrasound comprises a duration of exposure of from about 0.5 min to about 10 mins.5. The method of claim 2 , wherein the intermittent low-density-diffuse ultrasound comprises exposure at an interval of from about 8 times per day up to about 16 times per day.6. The method of claim 1 , wherein the cells are selected from the group consisting of osteoblasts claim 1 , osteoclasts claim 1 , osteocytes claim 1 , chondrocytes claim 1 , hepatocytes claim 1 , islet cells claim 1 , myocytes claim 1 , epithelial cells claim 1 , kidney cells claim 1 , neurons and stem cells.7. The method of claim 1 , wherein the tissue is selected from the group consisting of bone claim 1 , cartilage claim 1 , liver claim 1 , pancreas claim 1 , muscle claim 1 , epithelium claim 1 , kidney claim 1 , uterus claim 1 , ovarian claim 1 , and testes.8. A method of inducing phosphorylation in cells by extracellular signal-regulated kinases 1 and 2 (Erk1/2) claim 1 , comprising:exposing cells in culture to intermittent low-intensity-diffuse ultrasound.9. A method of inducing reorganization of actin in cells claim 1 , comprising:exposing cells in culture to intermittent low-intensity-diffuse ultrasound.10. A bioreactor for culturing cells or tissue claim 1 , wherein the bioreactor comprises at least one ultrasonic transducer configured to ...

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Номер записи: 62
06-02-2014 дата публикации

FLUIDIC IN-LINE PARTICLE IMMOBILIZATION AND COLLECTION SYSTEMS AND METHODS FOR USING THE SAME

Номер: US20140038259A1
Автор: Chen Yong
Принадлежит: BECTON, DICKINSON AND COMPANY

Fluidic sorting systems configured to immobilize, and optionally concentrate and/or analyze, one or more particles within the system are provided. Aspects of the systems include a flow-through chamber and an immobilization component configured to immobilize, preferably reversibly, a particle within the flow-through chamber. Optionally, the systems include an analysis component configured to optically analyze an immobilized particle within the flow-through chamber. In certain aspects, the systems are configured to collect one or more particles from the flow-through chamber for subsequent analysis, experimentation, and/or use. Also provided are methods, components and kits for reversibly immobilizing, and optionally analyzing, one or more particles within a fluidic sorting system. 1. A fluidic sorting system comprising:a flow-through chamber configured to receive a particle in a fluid stream from a catcher tube; anda particle immobilization component configured to reversibly immobilize the particle within the flow-through chamber.2. The fluidic sorting system according to claim 1 , wherein the particle immobilization component comprises a magnetic field generator.3. The fluidic sorting system according to claim 2 , wherein the magnetic field generator comprises a permanent magnet.4. The fluidic sorting system according to claim 2 , wherein the magnetic field generator comprises an electromagnet.5. The fluidic sorting system according to claim 1 , further comprising an analysis component configured to analyze the immobilized particle within the flow-through chamber.6. The fluidic sorting system according to claim 5 , wherein the analysis component comprises a microscope.7. The fluidic sorting system according to claim 6 , wherein the microscope is selected from the group consisting of: a conventional microscope claim 6 , a fluorescence microscope claim 6 , a confocal microscope claim 6 , and a laser scanning microscope.8. The fluidic sorting system according to claim 1 ...

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Номер записи: 63
13-02-2014 дата публикации

EMERGENCY STOPPING DEVICE

Номер: US20140042003A1
Автор: Benni Dominique, Meftah Tewfik
Принадлежит: Schneider Electric Industries SAS

The invention relates to an emergency stopping device, comprising a body (), a control button () that is movable in translation along a control axis (X), at least one normally closed electrical contact unit (), an actuation member () which can be actuated by said control button () so as to translate between a inoperative position and an actuated position, and which engages with the contact unit (), a holding member () engaging with the actuation member () and capable of assuming a locking position for maintaining the actuation member in the actuated position thereof, and an unlocking ring () which is separate from the control button and which can be rotatably actuated, and which engages with the actuation member () so as to release the latter with a view to driving same toward the inoperative position thereof. 1101113121113121121512. An emergency stopping device comprising a body () , a control button () which is movable in translation along a control axis (X) , at least one electrical contact unit () of the normally closed type , an actuation member () which can be actuated in translation by said control button () between an inoperative position and an actuated position in order to act on the contact unit () , a holding member () cooperating with the actuation member () and able to assume a locking position in order to hold the actuation member in its actuated position , characterized in that it comprises an unlocking ring () which can be actuated in rotation and cooperates with the actuation member () to release it with the aim of driving it towards its inoperative position.2151111. The device as claimed in claim 1 , characterized in that the unlocking ring () rotates as one with the control button () and is fitted in a manner coaxial to the control button ().321112. The device as claimed in claim 1 , characterized in that it comprises an opening spring (R) arranged between the control button () and the actuation member ().4120121012122. The device as claimed in ...

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Номер записи: 64
20-02-2014 дата публикации

HOUSEHOLD APPLIANCE COMPRISING A KNOB WHICH OPERATES SILENTLY

Номер: US20140047943A1
Автор: Camli Ugur, Gocer Mehmet Baris
Принадлежит:

The present invention relates to a household appliance () comprising a control panel () that has a front plate () and a rear plate () adjacent to each other placed one in front of the other, a knob hole () that is located on the control panel (), a retractable and rotary knob () that moves inside the knob hole () and a bearing () that is disposed into the knob hole () and supports the knob () so that the knob () slidably move therein by surrounding the knob (), and wherein the knob () is provided to operate silently inside the bearing (). 114235465756668235. A household appliance () comprising a control panel () which has a front plate () and a rear plate () adjacent to each other placed one in front of the other , a knob hole () which is located on the control panel () , a retractable and rotary knob () which moves inside the knob hole () and a bearing () which is disposed into the knob hole () and supports the knob () so that the knob () slidably move therein by surrounding the knob () , characterized in that an elastic damping member () which is disposed between the front plate () and the rear plate () and which surrounds the knob hole ().218423. The household appliance () as in claim 1 , wherein the damping member () which is an elastomeric ring disposed into the control panel () by being pressed between the front plate () and the rear plate ().31823. The household appliance () as in claim 1 , wherein the damping member () which is produced from silicon and provides the front plate () and the rear plate () to be adhered.4123. The household appliance () as in claim 3 , wherein the front plate () produced from metal and the rear plate () produced from glass.5132. The household appliance () as in claim 4 , wherein the rear plate () claim 4 , the thickness of which is greater than the thickness of the front plate ().6132. The household appliance () as in claim 5 , wherein the rear plate () claim 5 , the hardness value of the material of which it is produced from is ...

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Номер записи: 65
27-02-2014 дата публикации

Driven Machine Tool, in Particular an Angle Grinder or a Straight Grinder

Номер: US20140054146A1
Автор: Hiller Matthias
Принадлежит: METABOWERKE GMBH

The present invention relates to a driven machine tool, and in particular to an angle grinder or a straight grinder, and which includes a drive unit having a drive switch for switching the drive unit on and off, a housing in which the drive unit is at least partially received, and an actuation mechanism for actuating the drive switch. 1. A driven machine tool comprising: a drive unit having a drive switch for switching the drive unit on and off; a housing in which the drive unit is at least partially received; and an actuation mechanism for actuating the drive switch , and wherein the actuation mechanism has a switching rod which can be displaced along a longitudinal axis (L) of the housing and which further protrudes through a recess of the housing and which includes an actuation portion , and a switching lever which is pivotably supported at a bearing location and which further has at least one lever arm , and wherein the switching rod is connected to the at least one lever arm and is further able to pivot the at least one lever arm as a result of the displacement thereof , and wherein the bearing location of the switching lever is borne on the housing.2. A driven machine tool as claimed in claim 1 , andwherein the switching rod is connected to the at least one lever arm at a free end of the switching lever.3. A driven machine tool as claimed in claim 2 , andwherein the free end of the connected lever arm is received in a recess defined by the switching rod.4. A driven machine tool as claimed in claim 3 , andwherein the switching lever has a rounded outer contour at the free end of the connected lever arm and the recess in the switching rod has a substantially corresponding contour.5. A driven machine tool having a drive switch claim 3 , comprising: an actuation mechanism having a switching rod which can be displaced along a longitudinal axis (L) of a housing of the driven machine tool and which protrudes through a recess defined by the housing and which includes ...

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Номер записи: 66
27-02-2014 дата публикации

Rotational Control Mechanism for an Electrical Tool

Номер: US20140054147A1
Автор: Yang Dancheng
Принадлежит:

The present invention relates to a rotational control mechanism for an electrical tool comprising a micro switch having a triggering portion, a frame to securely dispose the micro switch, a revolver pivotally connected on the frame via a rotating shaft, and a triggering element disposed on and paralleled with an inner lateral wall of the revolver to trigger the triggering portion of the micro switch of the frame. The rotational control mechanism is benefited via the revolver pivotally connected with the frame, and the triggering element disposed on the inner lateral wall of the revolver and parallel with the wall to trigger the triggering portion of the micro switch, therefore overcomes shortcomings of the existing control mechanism including the revolver being unable to rotate and the triggering portion tending to be false triggered easily, and achieves technical effects of flexible and reliable control, stable performance, compact structures and reliable transmission. 1. A rotational control mechanism for an electrical tool , comprising a micro switch having a triggering portion , wherein the rotational control mechanism further comprises:a frame, the micro switch being securely disposed thereon; anda revolver pivotally connected on the frame via a rotating shaft, and a triggering element being disposed on an inner lateral wall of the revolver and parallel with the inner lateral wall to trigger the triggering portion of the micro switch disposed on the frame.2. The rotational control mechanism for an electrical tool as claimed in claim 1 , wherein a trough is disposed on an edge of the triggering element claim 1 , and symmetric curve surfaces are convexly formed on two edges of the trough claim 1 , the triggering portion engages within the trough claim 1 , and is retracted out of or inserted into the trough in conjunction with rotation of the revolver.3. The rotational control mechanism for an electrical tool as claimed in claim 1 , wherein a torsion spring is ...

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Номер записи: 67
06-03-2014 дата публикации

DEVICE FOR CONTROLLING MOTION OF ANTI-COLLISION SWITCH AND MEDICAL DIAGNOSIS APPARATUS EMPLOYING THE SAME

Номер: US20140059767A1
Автор: Kim Jung-Min, YANG Chang-jin
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

In a device for controlling an operation of an anti-collision switch, the anti-collision switch is provided in a support close to a guide frame that is provided at at least one of both lateral sides of a table frame, to prevent collision of the table frame that is supported on the table support to be capable of moving in a lengthwise direction. The device includes a first lever coupled to the table support so that at least a portion of the first lever moves in a vertical direction according to deformation of the guide frame, and a second lever pressing the anti-collision switch in a normal state and, when a vertical movement of the first lever deviates from a preset height, being moved up by the first lever to remove pressing of the anti-collision switch and operate the anti-collision switch. 1. A device for controlling an operation of an anti-collision switch , the anti-collision switch being provided in a table support adjacent to a guide frame that is provided at at least one of both lateral sides of a table frame that is supported on the table support to be capable of moving in a lengthwise direction , the device comprising:a first lever coupled to the table support so that at least a portion of the first lever moves in a vertical direction according to deformation of the guide frame; anda second lever pressing the anti-collision switch in a normal state and, when a vertical movement of the first lever deviates from a preset height, being moved up by the first lever to release the anti-collision switch.2. The device of claim 1 , wherein a gap adjustment member for adjusting a gap between the first lever and the second lever is provided on the first lever such that the gap adjustment member collides against the second lever when the first lever is moved upwardly.3. The device of claim 2 , wherein the gap adjustment member is any one of a bolt claim 2 , a screw claim 2 , and a protruding pin.4. The device of claim 1 , further comprising:a first elastic member ...

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Номер записи: 68
13-03-2014 дата публикации

METHOD OF BREAKING DOWN BIOLOGICAL MATERIAL

Номер: US20140070033A1
Автор: Klaseboer Evert, Ohl Claus-Dieter, Ohl Siew-Wan, Ow Siak-Wei Dave, Tandiono Tandiono
Принадлежит:

In various embodiments, a method of breaking down biological material is provided. The method may include providing a sample comprising the biological material in a liquid. The method may further include providing a gas such that the gas forms an interface with the liquid. The method may also include breaking down the biological material by applying acoustic waves in a plurality of sequential bursts to the interface. 1. A method of breaking down biological material , the method comprising:providing a sample comprising the biological material in a liquid;providing a gas such that the gas forms an interface with the liquid; andbreaking down the biological material by applying acoustic waves in a plurality of sequential bursts to the interface.2. The method according to claim 1 ,wherein cavitations are generated by oscillations when the acoustic waves are applied to the interface; andwherein the cavitations are configured to break down the biological material.3. The method according to claim 1 ,wherein the biological material are broken down into biological material fragments.4. The method according to claim 3 , the method further comprising:detecting the biological material fragments.5. The method according to claim 3 , the method further comprising:increasing pressure of the gas to flush the biological material fragments.6. The method according to claim 3 , the method further comprising:decreasing the pressure of the gas after flushing the sample comprising the biological material fragments.7. The method according to claim 3 , the method further comprising:providing a subsequent sample comprising a subsequent biological material after flushing the sample comprising the biological material fragments.8. The method according to claim 1 ,wherein a first burst of the plurality of sequential bursts is separated from a second burst of the plurality of sequential bursts by a time interval.9. The method according to claim 1 ,wherein the interface is formed in a main channel ...

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Номер записи: 69
13-03-2014 дата публикации

STATIONARY CONTACT ARM ASSEMBLY FOR MOLDED CASE CIRCUIT BREAKER

Номер: US20140070908A1
Автор: JANG Jun Yong
Принадлежит: LSIS CO., LTD.

A stationary contact arm assembly for a molded case circuit breaker includes a stationary contact arm having a terminal portion and a contact portion provided at both end portions thereof in the length direction, and an inclined extension portion provided between the contact portion and the terminal portion, a flat extension portion forming a space between the flat extension portion and a bottom surface of the contact potion, a bent portion formed from the flat extension portion to the terminal portion; a magnet assembly having a plurality of steel plates at least part of which is installed to be pushed into a space between the flat extension portion and contact portion in the stationary contact arm; and an elastic support plate having an elastic support portion installed on the flat extension portion of the stationary contact arm to support the magnet assembly. 1. A stationary contact arm assembly for a molded case circuit breaker , comprising:a current limiting type stationary contact arm having a terminal portion and a contact portion provided at both end portions thereof in the length direction, and an inclined extension portion provided between the contact portion and the terminal portion and formed to be downwardly extended in an inclined manner from the terminal portion, a flat extension portion forming a space between the flat extension portion and a bottom surface of the contact potion, a bent portion formed in a bent shape from the flat extension portion to the terminal portion;a magnet assembly having a plurality of steel plates at least part of which is installed to be pushed into the space between the flat extension portion and contact portion in the stationary contact arm to enhance the magnetic permeability so as to increase an electromagnetic repulsive force during the current limiting operation; andan elastic support plate having an elastic support portion installed on the flat extension portion of the stationary contact arm to support the magnet ...

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Номер записи: 70
27-03-2014 дата публикации

CONTROL APPARATUS FOR AIR CONDITIONING SYSTEM OF VEHICLE

Номер: US20140083237A1
Автор: Kim Myung Hoe
Принадлежит:

A control apparatus for an air conditioning system of a vehicle, may include a knob selectively rotatable by a user's operation, a cam to which an inner wire of a cable may be connected, the cam being rotated through a rotation force transmitted from the knob, a cable holder that holds and supports a skin layer of the cable slidably surrounding the inner wire of the cable, wherein the cable holder may be pivotally coupled to a vehicle body. 1. A control apparatus for an air conditioning system of a vehicle , comprising:a knob selectively rotatable by a user's operation;a cam to which an inner wire of a cable is connected, the cam being rotated through a rotation force transmitted from the knob;a cable holder that holds and supports a skin layer of the cable slidably surrounding the inner wire of the cable, wherein the cable holder is pivotally coupled to a vehicle body.2. The control apparatus for the air conditioning system of the vehicle of claim 1 , wherein a rotation axis of the cable holder is provided in parallel to a rotation axis of the cam.3. The control apparatus for the air conditioning system of the vehicle of claim 1 ,wherein the cam is engaged with the knob via a plurality of gears disposed therebetween, andwherein the cam receives the rotation force from the knob through the plurality of gears while an end of the inner wire is connected rotatably to a front end of the cam projected in a radial direction from a rotation axis of the cam.4. The control apparatus for the air conditioning system of the vehicle of claim 3 ,wherein the cam is formed integrally with a bevel gear portion around a rotation axis of the bevel gear portion, andwherein a pinion gear provided with a bevel gear that is meshed with the bevel gear portion of the cam.5. The control apparatus for the air conditioning system of the vehicle of claim 4 , wherein a rotation axis of the pinion gear is aligned in parallel to a rotation axis of the knob.6. The control apparatus for the air ...

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Номер записи: 71
27-03-2014 дата публикации

MAGNETIC THREE-DIMENSIONAL CELL CULTURE APPARATUS AND METHOD

Номер: US20140087440A1
Автор: BECKER JEANNE L., COFFIN SUSAN B.
Принадлежит: UNIVERSITY OF SOUTH FLORIDA

A culture apparatus and method for growing cells and tissue in a three-dimensional configuration harnesses magnetic, paramagnetic, ferromagnetic and diamagnetic forces. The cells or tissue are grown with magnetized core particles and are suspended via magnetic forces in a native, non-restricted, three-dimensional configuration while being maintained in a normal gravity (1 g) growth environment in the absence of rotational alteration of the gravity vector. 122-. (canceled)23. An apparatus comprising:a first diamagnet;a second diamagnet disposed in transversely spaced apart relation to said first diamagnet; andan upper lifter magnet disposed in abutting relation to said first diamagnet.24. The apparatus of claim 23 , wherein said apparatus further comprises a cell culture chamber; and wherein said culture chamber is positioned in sandwiched relation between said first and second diamagnets.25. The apparatus of claim 24 , wherein said cell culture chamber contains a cell culture medium and a plurality of magnetized core particles.26. The apparatus of claim 25 , wherein said cell culture chamber includes biological cells to be cultivated.27. The apparatus of claim 24 , wherein said cell culture chamber is formed of a gas permeable material.28. The apparatus of claim 24 , further comprising:an inlet port formed in said cell culture chamber at a first end of said cell culture chamber; andan outlet port formed in said cell culture chamber at a second end of said cell culture chamber, said second end being spaced apart from said first end.29. The apparatus of claim 25 , wherein said magnetized core particles are coated with a cellular adhesive material.30. The apparatus of claim 25 , wherein said magnetized core particles are coated with a collagen component.31. The apparatus of claim 25 , wherein said magnetized core particles are coated with a matrix component.32. The apparatus of claim 31 , wherein said matrix component is non-biodegradable.33. The apparatus of claim 31 ...

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Номер записи: 72
03-04-2014 дата публикации

METHODS AND APPARATUSES FOR ISOLATING AND PREPARING STEM CELLS

Номер: US20140093482A1
Автор: Paspaliaris Bill, Thornton James Andrew Farrant
Принадлежит: AdiStem, Ltd.

The present invention relates to a method of preparing a population of stem cells for autologous implantation to a subject. The cells are activated by irradiating the cells with one or more wavelengths of yellow and red and/or green light. In particular, the cells are irradiated with 575-595 nm (5-20 mW), and 630-635 nm or 660-670 nm (10-100 mW) and/or 510-540 nm (10-60 mW) of monochromatic light for 30-60 mins. Preferably the stem cells are adipose-derived stem cells. Also the invention relates to therapeutic applications of the activated stem cells. 1. A method of preparing a population of stem cells for autologous implantation to a subject , comprising activating the stem cells by irradiating the cells with one or more wavelengths of yellow and red and/or green light.2. The method of wherein yellow and red and green light is used.3. The method of wherein the cells are irradiated with 575-595 nm (5-20 mW) claim 1 , and 630-635 nm (10-100 mW) and/or 510-540 nm (10-60 mW) of monochromatic light for 30-60 mins.4. The method of wherein the cells are irradiated with 595 nm (20 mW) claim 3 , 635 nm (60 mW) and 535 nm (60 mW) of monochromatic light claim 3 , for 30-60 mins.5. The method of claim 1 , comprising a further initial step of processing a sample of tissue from the subject to obtain the population stem cells to be irradiated.6. The method of wherein the stem cells are adult stem cells.7. The method of wherein the adult stem cells are adipose-derived stem cells (ADSC); dermal stem cells; hematopoietic stem cells; mammary stem cells; mesenchymal stem cells; endothelial stem cells; neural stem cells; neural crest stem cells; or testicular stem cells.8. The method of wherein the stem cells are ADSC and the tissue is adipose tissue.9. The method of wherein the stem cells are exposed to one or more growth factors.10. The method of wherein the growth factors are Epidermal Growth Factor (EGF); Platelet-Derived Growth Factor (PDGF); Fibroblast Growth Factor (FGFs); ...

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Номер записи: 73
07-01-2016 дата публикации

METHOD FOR DIGITAL TRANSDUCTION OF DNA IN LIVING CELLS

Номер: US20160002620A1
Автор: Montagnier Luc
Принадлежит:

A system and method for inducing cytotoxicity, comprising a receiver configured to receive an electromagnetic signal from a container, using a receiver configured to capture electromagnetic emissions from the container over a frequency range of at least 100 Hz to 10,000 Hz; an amplifier configured to amplify the received electromagnetic signal; and an emitter configured to emit the amplified electromagnetic signal in proximity to living cells. DNA from a pathogen is amplified using PCR, purified, and serially diluted. Electromagnetic signals from the diluted DNA are received, and optionally stored. The receive signal is amplified and emitted in proximity to living cells, to produce under selected circumstances, a cytopathic effect. 1. A method of producing cytotoxicity , comprising:amplifying DNA from a pathogen using polymerase chain reaction technology;purifying the amplified DNA;serially diluting and mixing the purified DNA in water, to generate a dilute DNA sample in a container;receiving an electromagnetic signal from the container, using a receiver configured to capture electromagnetic emissions from the container over a frequency range of at least 100 Hz to 10,000 Hz;optionally recording the received electromagnetic signal;amplifying the received or optionally recorded electromagnetic signal; andemitting the amplified electromagnetic signal in proximity to living cells.2. The method according to claim 1 , wherein the purified DNA is constituted as 2 ng/ml in water claim 1 , and serially diluted over a range within 10to 10.3. The method according to claim 1 , wherein the received electromagnetic signal is digitally recorded for about 6 seconds over a bandwidth of at least 400 Hz to 4 kHz.4BorreliaRicketsiales.. The method according to claim 1 , wherein the pathogen is of a genus selective from the group consisting of and5. The method according to claim 1 , wherein serial dilutions of the purified DNA are analyzed for significant electromagnetic emissions by ...

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Номер записи: 74
05-01-2017 дата публикации

ACTUATOR FOR A VACUUM SWITCH TUBE OF A SWITCHING ASSEMBLY OF A TAP CHANGER

Номер: US20170004943A1
Автор: HEROLD Stefan, Hoepfl Klaus
Принадлежит:

An actuator () for actuating a vacuum switch tube () comprising a fixed contact () and a movable contact (), comprises 1. An actuator for actuating a vacuum switch tube , the actuator comprising:a fixed contact;a movable contact;a bearing plate that can be fastened to the fixed contact;a main spring having a first end with which it can engage the movable contact and a second end;a return spring having a first end with which it engages at the bearing plate and a second end; andan actuating lever having a first engagement area at which the main spring engages with its second end, and having a second engagement area at which the return spring engages with its second end, the actuating lever being swivelably mounted on the bearing plate such that the actuating lever can assume a first end position in which the main spring is at least partially relaxed and the return spring is tensioned, and a second end position in which the return spring is at least partially relaxed and the main spring is tensioned.2. The actuator according to claim 1 , wherein the main spring and the return spring are formed such that the actuating lever is biased into the first end position.3. The actuator according to claim 1 , wherein the main spring is a compression spring claim 1 , and its first end abuts on a first contact surface of the movable contact claim 1 , which first contact surface faces toward the first engagement area.4. The actuator according to wherein the return spring is a compression spring claim 1 , and its first end abuts on a contact surface of the bearing plate claim 1 , which contact surface faces toward the second engagement area.5. The actuator according to claim 1 , whereinthe actuating lever has a first lever arm on which the first engagement area and the second engagement area are formed;the longitudinal axis of the main spring is parallel to the longitudinal axis of the return spring; andthe contact surface of the bearing plate faces toward the main spring.6. The ...

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Номер записи: 75
07-01-2016 дата публикации

BREAK-OFF-RESISTANT CONTROL DEVICE

Номер: US20160005558A1
Автор: BEKAERT Jean-Phillippe
Принадлежит:

Control device, including: 1. A control device , comprising:{'b': 60', '6', '1', '1, 'a commutator () which has a body () and a control rod () which extend along an axis (A), the control rod () being of plastics material and mounted at least with a degree of freedom relative to the body,'}{'b': 2', '12', '1, 'a button () of molded plastics material which comprises an axial recess () having an axis (A) in which the control rod () is at least partially received,'}{'b': 3', '1, 'an anchoring ring () which is produced from sheet metal which is cut and folded and which is arranged around the control rod (),'}{'b': 4', '3', '6', '4', '41', '1, 'first resilient plates () which are arranged on the anchoring ring () and which are directed counter to the body () and which are oblique in the direction of the axis (A), each plate () having a free end () in abutment with the control rod (),'}{'b': 5', '3', '5', '2, 'resilient lugs () which are arranged on the anchoring ring () and which are directed toward the body and which are orientated in an oblique manner in a direction away from the axis (A), the resilient lugs () being in abutment with the button ().'}25. The control device as claimed in claim 1 , wherein the resilient lugs () are second plates with a sharp edge.35. The control device as claimed in claim 2 , wherein the second plates () comprise pointed pins.4414741. The control device as claimed in claim 1 , wherein at least one of the free ends () of the first plates () comprises a cutting burr () which promotes the penetration of the plate () into the control rod ().5. The control device as claimed in claim 1 , wherein the at least one degree of freedom is a rotation about the axis (A).645. The control device as claimed in claim 1 , wherein the first plates () and the resilient lugs () are alternated circumferentially.75932. The control device as claimed in claim 1 , wherein the resilient lugs () are resilient clips which are received against a support portion () of ...

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Номер записи: 76
07-01-2021 дата публикации

SAFETY SWITCH INPUT DIAGNOSIS DEVICE AND WORK MACHINE USING SAFETY SWITCH INPUT DIAGNOSIS DEVICE

Номер: US20210005402A1
Автор: Ishimoto Hidefumi, KIRIMURA Akiyoshi, KURAMOCHI Yuichi
Принадлежит:

A safety switch input diagnosis device includes a circuit formed from a series connection of an emergency stop switch and a line having a resistor. A connection state of the emergency stop switch and failure modes of the lines are diagnosed on the basis of a voltage value at one end of the circuit. Consequently, an operation of the switch and failure modes of a circuit relating to the switch can be diagnosed. 1. A safety switch input diagnosis device , comprising:a first circuit formed from a series connection of a switch capable of interrupting connection between a first contact and a second contact and a line having a first resistor connected to the first or the second contact of the switch;a second circuit having a second resister between one end and another end and connected at the one end to one end of the first circuit;a third circuit connected at one end to the other end of the second circuit and at another end to a power supply;a fourth circuit connected at one end to another end of the first circuit;a fifth circuit having a third resistor between one end and another end and connected at the one end to another end of the fourth circuit and at the other end to a ground;a sixth circuit having a fourth resistor between one end and another end and connected at the one end to the one end of the first circuit and at the other end to the other end of the first circuit;a seventh circuit connected at one end to the other end of the first circuit;an eighth circuit having a fifth resistor between one end and another end and connected at the one end to another end of the seventh circuit and at the other end to the ground; anda controller that diagnoses a connection state of the switch and failure modes of the third, the fourth, and the seventh circuits on a basis of a voltage value at the one end of the eighth circuit and outputs a result of diagnosis.2. The safety switch input diagnosis device according to claim 1 , whereinresistance values of the first to the fifth ...

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Номер записи: 77
07-01-2021 дата публикации

Control knob for an appliance having rotational and axial selection interface

Номер: US20210005403A1
Автор: Fanmeng Hua, Hongqiang Wang, Yujin Mao, Yukai HUANG
Принадлежит: Whirlpool China Co Ltd

A control knob for an appliance includes a base having an axially-operated switch. An outer control assembly is rotationally and axially operable with respect to the base. An inner display assembly is rotationally fixed with respect to the base and axially fixed with respect to the outer control assembly. The inner display assembly is biased toward an extended state and is axially operable to a selection state that engages the axially operated switch.

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Номер записи: 78
08-01-2015 дата публикации

SEVEN UNIVERSE INDUSTRIAL CO., LTD.

Номер: US20150007685A1
Автор: Chang Pao-Chi
Принадлежит:

The present invention provides a button set for gas valve, which is characterized by that, multiple oil chambers are set on inner wall of the axle hole of the axle hole on the upper cover of the button set in relation to the surface of the rotating axle; this could accommodate lubricant and reduce the contact area between the rotating axle and axle hole, thus improving the rotating smoothness of the rotating axle within the axle hole and reducing the machining accuracy. 1. A button set for gas valve , of which the gas valve comprises a main body and a closer set rotarily arranged into the main body , and the button set is arranged at one end of the main body and linked to the closer set for driving the rotation of the closer set; comprising:an upper cover, set at one end of the main body with an axle hole;a rotating axle, rotarily set into the axle hole of the upper cover; andmultiple oil chambers are set between the axle hole of the upper cover and the rotating axle, this could accommodate lubricant to maintain the rotating smoothness of the rotating axle in the axle hole, and reduce the contact area between the inner wall of the axle hole and the rotating axle.2. The structure defined in claim 1 , wherein said oil chamber is set onto inner wall of the axle hole.3. The structure defined in claim 2 , wherein said oil chamber is formed by multiple grooves claim 2 , and extended between one end of the axle hole correspondingly to the closer set and the inner wall at other end of the axle hole.4. The structure defined in claim 3 , wherein said grooves are of elongated pattern and extended axially in parallel to the rotating axle.5. The structure defined in claim 1 , wherein said oil chamber is set on the surface of the rotating axle.6. The structure defined in claim 5 , wherein said oil chamber is formed by multiple grooves.7. The structure defined in claim 6 , wherein said grooves are of elongated pattern and extended axially in parallel to the rotating axle.8. The ...

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Номер записи: 79
03-01-2019 дата публикации

Multi-pole electrical switching apparatus and trip cam assembly therefor

Номер: US20190006131A1
Автор: James G. Maloney
Принадлежит: Eaton Corp

A trip cam assembly is for a multi-pole electrical switching apparatus. The trip cam assembly includes a first trip cam, a second trip cam, and an interconnect member coupled to the first trip cam and the second trip cam.

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Номер записи: 80
03-01-2019 дата публикации

LIGHT SWITCH HOOK ASSEMBLY

Номер: US20190006132A1
Автор: Kari Atalla H., Shaheen James C.
Принадлежит:

A light switch hook assembly including a light switch plate and a hook extending outwardly therefrom. A fastener is inserted through an aperture defined in the hook and then into a hole defined in the light switch plate. The end of the fastener is subsequently inserted into an opening defined in a light switch mounted within an electrical connector box. The light switch plate may already be installed on a wall. In this instance, a fastener is removed from this pre-existing light switch plate, the hook is positioned against the plate, and the fastener is inserted through the aperture in the hook, through the hole from which the fastener was previously removed, and into the opening in the light switch. A cover may be engaged with the hook to cover the head of the fastener. An article may be hung on the hook. 1. A light switch hook assembly comprising:a light switch plate having a front surface and a rear surface, said light switch plate being adapted to be secured to a light switch;a hook extending outwardly from the front surface of the plate; anda fastener that extends through an aperture defined in one of the hook and the light switch plate, wherein said fastener is adapted to be engaged with the light switch.2. The light switch hook assembly as defined in claim 1 , wherein the aperture is defined in the hook and a hole is defined in the light switch plate; and a shaft of the fastener is inserted through the aperture and the hole when aligned with each other.3. The light switch hook assembly of claim 1 , wherein the aperture is defined in the hook and the aperture includes a first region of a first diameter and a second region of a second diameter claim 1 , wherein the first region opens at a front surface of the hook and the second region opens at a rear surface of the hook.4. The light switch hook assembly of claim 3 , wherein the first region of the aperture and the second region of the aperture are concentric.5. The light switch hook assembly of claim 3 , ...

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Номер записи: 81
08-01-2015 дата публикации

On-load tap changer with two vacuum interrupters and drive therefor

Номер: US20150008104A1
Автор: Christian Kotz, Klaus Hoepfl, Silke Wrede
Принадлежит: Maschinenfabrik Reinhausen GmbH

An on-load tap changer ( 1 ) having at least two vacuum interrupters ( 3 ) is disclosed. The on-loader tap changer comprises a selector ( 7 ) for selecting a respective winding tap (n, n+1) of a tapped transformer ( 9 ), a load changeover switch ( 5 ) for changing over from the connected winding tap (n) to the respectively preselected winding tap (n+1), a rotatable drive shaft ( 11 ) which is mechanically coupled to the selector ( 7 ), and a gear mechanism ( 15 ) for operating a moving contact ( 17 ) of a respective vacuum interrupter ( 3 ). In each case one spindle ( 19 ) which can move in a direction of the axis (A) and is coupled to the moving contact ( 17 ) can be operated by means of the gear mechanism ( 15 ). The invention also relates to a drive for a load changeover switch having at least two vacuum interrupters.

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Номер записи: 82
27-01-2022 дата публикации

Modular Input Interface Device with Multi-Axial Interaction

Номер: US20220026944A1
Автор: Harris Daren
Принадлежит: HARMAN INTERNATIONAL INDUSTRIES, INCORPORATED

A modular input interface device having multi-axial functionality in a housing having an input interface that is capable of up to seven directions of movement. The modular interface device provides input to at least one processor associated with one or more vehicle systems. 1. A modular input interface device comprising:a housing having a left face, a right face, a front face and a rear face, each face having an opening to an interior of the housing;a slot on an exterior surface of the housing at each of the left, right, front and rear faces of the housing;a base portion positioned inside the housing at a bottom portion of the housing;an inner base within the housing, the inner base cooperates with the base portion and remains stationary relative to the housing;an outer ring at a top portion of the housing, the outer ring cooperates with and rotates above the inner base; anda first pair of sensors on the inner base that detect rotational movement of the inner base.2. The device according to claim 1 , further comprising:a male inner housing positioned through a center of the outer ring, the male inner housing is attached to the inner base;a rotary bearing circumferentially disposed between the outer ring and the male inner housing.3. The device according to claim 1 , further comprising:a first slide cage within the housing, the first slide cage is positioned between the base portion and the inner base, the first slide cage has slots in first and second lateral directions to allow movement of the outer ring in the first and second lateral directions to be translated to and limit movement of the first slide cage to a predetermined distance in each of the first and second lateral directions; anda second pair of sensors to detect movement of the first slide cage in the first and second lateral directions, the second pair of sensors are positioned in slots on the left and right faces of the housing.4. The device according to claim 3 , further comprising:a second slide ...

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Номер записи: 83
14-01-2021 дата публикации

COOKING APPLIANCE HAVING A REMOVABLE CONTROL PANEL

Номер: US20210010676A1
Автор: Davison Daniel, Hanna Charles, Russell James, White Tyson
Принадлежит:

A removable control panel console for a cooking appliance may include a front panel having upper fingers that hook onto apertures in a bullnose feature of the appliance. The control panel console is pivotable in this configuration, and may be secured to the appliance by raising the front panel to fully insert the fingers into the apertures and fastening a bottom wall of the control panel to the appliance. Side walls of the control panel console may include tabs that are received into corresponding slots in a front surface of the appliance, providing an additional alignment and security feature. 1. A cooking appliance comprising:a stove having a cooktop mounted above an oven;a bullnose extending from a front of the cooktop; anda removable control panel console including one or more user interface (UI) elements mounted to a front face of the control panel console and configured to control the cooktop, wherein bottom, left, and right walls extend orthogonally from the front face, and a plurality of spaced-apart fingers extend upward from a top edge of the front face, the fingers having hooked distal ends;wherein the control panel console is transitionable between (a) a first configuration, in which the hooked distal ends of the fingers are engaged with bottom edges of corresponding apertures in a bottom flange of the bullnose, such that the bottom wall of the control panel console is free to pivot away from the stove, and (b) a second configuration, in which the top edge of the control panel console abuts a bottom of the bullnose and the bottom wall is secured to the stove.2. The cooking appliance of claim 1 , wherein the bottom wall is secured to a lip of a floor of a cooktop chassis when in the second configuration.3. The cooking appliance of claim 1 , wherein the left and right walls each further comprise one or more tabs configured to be received by corresponding slots in the front of the cooktop.4. The cooking appliance of claim 3 , wherein each of the left and ...

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Номер записи: 84
15-01-2015 дата публикации

ELECTRICAL CONTACTOR

Номер: US20150015348A1
Автор: Connell Richard Anthony
Принадлежит:

An electrical contactor has a pair of first terminals and a pair of second terminals. Each first terminal has a fixed member with at least one fixed electrical contact facing the other fixed member. The second terminals having back-to-back electrically-conductive movable arms with an electrically-insulating partitioning element there between. Each second terminal is associated with a different one of the first terminals, and has a movable electrical contact on the associated movable arm which faces the corresponding fixed contact. When the contacts close, contra-flowing current through the back-to-back movable arms produces a repulsive force between the movable arms increasing a force between the fixed and movable contacts. 1. An electrical contactor comprising a pair of first terminals , each having a fixed member with at least one fixed electrical contact facing the other said fixed member;a pair of second terminals having back-to-back electrically-conductive movable arms with an electrically-insulating partitioning element therebetween;each second terminal being associated with a different one of the first terminals, and having a movable electrical contact on the associated movable arm which faces the corresponding fixed contact;the arrangement of the fixed members and the movable arms being such that, when the contacts close, contra-flowing current through the back-to-back movable arms produces a repulsive force therebetween which urges the movable arms away from each other, thereby increasing a force between the fixed and movable contacts.2. The contactor of claim 1 , further comprising an actuating arrangement claim 1 , wherein each movable arm includes a distal extension element extending distally of the movable contact and the actuating arrangement includes an urging member for outwardly biasing each distal extension element.3. The contactor of claim 2 , wherein each distal extension element is in-turned towards the partitioning element.4. The contactor of ...

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Номер записи: 85
15-01-2015 дата публикации

ELECTRICAL CONTACTOR

Номер: US20150015349A1
Автор: Connell Richard Anthony
Принадлежит:

An electrical contactor has a first terminal having an electrically-conductive fixed member with fixed contacts on opposite faces thereof, and a second terminal having a terminal body and an odd-number of electrically-conductive movable arms extending from the terminal body. Each movable arm has a movable contact thereon remote from the terminal body. The movable arms are arranged to oppose each other such that their movable contacts are on either side of the fixed member and aligned with the fixed contacts. The arrangement of the fixed member and the movable arms is such that, when the contacts close, current flowing through the movable arms produces a force which urges the movable arms towards each other thereby increasing a force between the fixed and movable contacts. The number of movable arms at each side of the fixed member is different. 1. An electrical contactor comprising a first terminal having an electrically-conductive fixed member with fixed contacts on opposite faces thereof; anda second terminal having a terminal body and an odd-number of electrically-conductive movable arms extending from the terminal body, each movable arm having a movable contact thereon remote from the terminal body;the odd-number of movable arms being arranged to at least substantially oppose each other and such that their movable contacts are on either side of the fixed member and aligned with the fixed contacts;the arrangement of the fixed member and the moveable arms being such that, when the contacts close, current flowing through the movable arms produces a force which urges the movable arms towards each other thereby increasing a force between the fixed and movable contacts.2. The electrical contactor of claim 1 , wherein a first number of said movable arms is provided at a first side of the fixed member claim 1 , and a second number of said movable arms opposing the first number of movable arms is provided at a second side of the fixed member claim 1 , the first number of ...

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Номер записи: 86
12-01-2017 дата публикации

HOUSEHOLD APPLIANCE WITH A CONTROL DEVICE

Номер: US20170013680A1
Автор: Gerstheim Sebastien
Принадлежит:

A domestic appliance includes at least one manually operable longitudinally or rotationally movable control device which is configured to adopt several latching positions. The latching positions are variably adjustable, for example adjusting a number of latching positions, or by adjusting a spacing between adjacent latching positions, or by adjusting a latching sensation of the latching positions. 110- (canceled)11. A domestic appliance , comprising at least one manually operable longitudinally or rotationally movable control device configured to adopt several latching positions , said latching positions being variably adjustable.12. The domestic appliance of claim 11 , further comprising a control facility claim 11 , said control device including adjustment electronics coupled to the control facility and configured to adjust the latching positions in response to data sent by the control facility.13. The domestic appliance of claim 11 , further comprising a control facility for adjusting the latching positions.14. The domestic appliance of claim 11 , wherein the latching positions are variably adjustable by adjusting a number of latching positions.15. The domestic appliance of claim 11 , wherein the latching positions are variably adjustable by adjusting a spacing between adjacent latching positions.16. The domestic appliance of claim 11 , wherein the latching positions are variably adjustable by adjusting a latching sensation of the latching positions.17. The domestic appliance of claim 16 , wherein different latching sensations are assigned to at least two latching positions.18. The domestic appliance of claim 11 , wherein the latching positions of the at least one control device is variable by a function of the control device.19. The domestic appliance of claim 11 , configured to operate at least one other domestic appliance claim 11 , with the control device representing an operating element for the at least one other domestic appliance.20. The domestic ...

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Номер записи: 87
09-01-2020 дата публикации

Heat Destructive Disconnecting Switch

Номер: US20200014155A1
Автор: I Hsiang-Yun
Принадлежит: GREEN IDEA TECH INC.

A heat destructive disconnecting switch comprises a first conductive member, a second conductive member, a movable conductive member, an overheating destructive member, an operating component, and a second elastic member. The movable conductive member conducts electricity to the first conductive member and the second conductive member. The overheating destructive member is formed as an integral body on a limiting member, and a first elastic member is compressed to between a contact member and the overheating destructive member, thereby providing the first elastic member with a first elastic force. The second elastic member is provided with a second elastic force. When the overheating destructive member is destructed due to overheating, the first elastic force is smaller than the second elastic force, causing the movable conductive member to disconnect the first conductive member from the second conductive member to achieve a protective effect from overheating. 1. A heat destructive disconnecting switch , comprising:a base, which is provided with a holding space;a first conductive member, which penetrates and is mounted on the base;a second conductive member, which penetrates and is mounted on the base;a movable conductive member, which is mounted within the holding space and electrically connected to the first conductive member, and selectively connects with the second conductive member;an overheating destructive member, which is destructed under a fail temperature condition, the fail temperature lying between 100° C. to 250° C.;an operating component, which is assembled on the base, wherein the operating component comprises an operating member and a first elastic member, the operating member comprises a contact member and a limiting member, the contact member contacts the movable conductive member; the overheating destructive member is formed as an integral body on the limiting member, the first elastic member is compressed and confined between the contact member ...

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Номер записи: 88
09-01-2020 дата публикации

Overheating Destructive Switch

Номер: US20200014157A1
Автор: I Hsiang-Yun
Принадлежит: GREEN IDEA TECH INC.

An overheating destructive switch, comprising: a first conductive element, a second conductive element, a movable conductive element, an overheating destructive element, an operating component, and a second elastic element. The movable conductive element connects the first conductive element and the second conductive element. A first elastic element and the second elastic element act on an operating element. The first elastic element is compressed and has a first elastic force, and the second elastic element has a second elastic force. The first elastic force is greater than the second elastic force under in a normal state. When the overheating destructive element is destroyed due to overheating, the first elastic force is reduced or lost, such that the second elastic force becomes greater than the first elastic force. The movable conductive element is consequently disconnected from the first conductive element and the second conductive element, thus achieving protection against overheating. 1. An overheating destructive switch , comprising:a base having a receiving space;a first conductive element penetrated into and provided in the base;a second conductive element penetrated into and provided in the base;a movable conductive element provided in the receiving space, electrically connected to the first conductive element and selectively connected to the second conductive element;an overheating destructive element destroyable at a destructive temperature, wherein the destructive temperature is between 100° C. to 250° C., and the overheating destructive element is located on the movable conductive element;an operating component assembled on the base, wherein the operating component comprises an operating element and a first elastic element, the first elastic element is compressively limited between the overheating destructive element and the operating element and has a first elastic force;a second elastic element having a second elastic force, wherein the second ...

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Номер записи: 89
21-01-2016 дата публикации

SENSOR ASSEMBLIES FOR LOCKS

Номер: US20160017638A1
Автор: Bangaru Dilip, Dore Vasudevan Sundar Raj, Litwinski Adam Michael, Madrid Allen
Принадлежит:

A locking assembly including first and second hubs rotatably mounted in a case, a latch assembly which retracts in response to rotation of either of the hubs, and a locking member which selectively prevents rotation of at least one of the hubs. A sensor assembly is associated with at least one of the hubs, and is configured to transmit a signal in response to rotation of the at least one hub.

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Номер записи: 90
17-04-2014 дата публикации

COMPOSITE OPERATING DEVICE

Номер: US20140102244A1
Автор: INOUE Masatomo
Принадлежит: SUMITOMO WIRING SYSTEMS, LTD.

A composite operating device includes a base, a slider, an operating member, a detecting element that detects that the operating member has been operated to slide, and a transmission member that transmits an operating force acting on the slider to the detecting element. The slider includes a transmission member pressing portion that presses the transmission member in the sliding direction. The transmission member includes a pressed portion that is pressed against by the slider and an element pressing portion that presses the detecting element in an element pressing direction. The base includes a transmission member retaining portion that rotatably retains the transmission member so that when the pressed portion is pressed by the transmission member pressing portion in the sliding direction, the transmission member rotates and therefore causes the element pressing portion to press against the detecting element. 1. A composite operating device that is operable to rotate about a specific axis of rotation and operable to slide in a specific sliding direction that is transverse to the axis of rotation , the composite operating device comprising:a base;a slider that is supported by the base so as to be slidable in the sliding direction relative to the base;an operating member that is retained by the slider so as to be rotatable about the axis of rotation and is operable so as to slide in the sliding direction together with the slider;a detecting element that detects that the operating member has been operated to slide to a specific sliding operation position in the sliding direction; and the slider comprises a transmission member pressing portion that presses the transmission member in the sliding direction,', a pressed portion that is pressed by the slider in the sliding direction; and', 'an element pressing portion that presses the detecting element in an element pressing direction that is parallel to the axis of rotation, and, 'the transmission member comprises, 'the ...

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Номер записи: 91
17-04-2014 дата публикации

COMPOSITE OPERATING DEVICE

Номер: US20140102245A1
Автор: INOUE Masatomo
Принадлежит: SUMITOMO WIRING SYSTEMS, LTD.

A composite operating device is provided which enables an operating member to be reliably guided in a sliding direction and achieves a simple structure for preventing disengagement of a slider. The composite device includes a base, a slider, and an operating member. The base includes a base main body, a guiding portion, and a restricting portion. The slider includes a guided portion and a restricted surface. The slider can slide in the sliding direction with the guided portion being restricted by first and second guiding surfaces. The restricting portion includes a sliding contact portion that restricts the slider and allows sliding of the slider by coming into sliding contact with the restricted surface. Also, the restricting portion has a shape that allows movement of the slider in a fitting direction by being deformed to bend in a direction in which the restricting portion is retracted from the slider. 1. A composite operating device that is operable to rotate about a specific axis of rotation and operable to slide in a specific sliding direction that is transverse to the axis of rotation , the composite operating device comprising:a base;a slider that is supported by the base so as to be slidable in the sliding direction relative to the base; andan operating member that is retained by the slider so as to be rotatable about the axis of rotation and is operable so as to slide in the sliding direction together with the slider, a base main body having an opposing surface that faces the slider in a direction parallel to the axis of rotation,', 'a guiding portion protruding from the opposing surface toward the slider and configured to guide the slider in the sliding direction, and', 'at least one restricting portion protruding from the opposing surface toward the slider at a position spaced apart from the guiding portion in a slide restriction direction that is orthogonal to the sliding direction and restricting displacement of the slider in a direction away from the ...

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Номер записи: 92
21-01-2016 дата публикации

ROTARY OPERATION TYPE ELECTRONIC COMPONENT

Номер: US20160020044A1
Автор: Fukushima Hajime, NAKAMURA Satomi
Принадлежит: Tokyo Cosmos Electric Co., Ltd.

A technology for making the heat load on an electronic component attached to a target object smaller than before is provided. The electronic component includes a main body, the main body including an electronic component unit adapted to generate an electrical signal and click feeling in accordance with rotation of an engaged portion, a shaft support having a cylindrical portion to be inserted into a through-hole formed in the target object, and a retaining member; and a control shaft made of metal and capable of rotating the engaged portion, the control shaft being inserted into the cylindrical portion after a reflow soldering process of the target object is completed, and being engaged with the engaged portion. The control shaft inserted into the cylindrical portion is retained by the retaining member.

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Номер записи: 93
21-01-2016 дата публикации

SYSTEM FOR DYNAMICALLY ADJUSTABLE DETENT

Номер: US20160020045A1
Автор: McAllister Glen
Принадлежит: Kostal of America

Dynamically adjustable rotary actuator devices are described. As a knob is rotated on an electronic system such as a radio and a limit is approached and ultimately reached (such as a volume limit), the described systems and methods create a progressive haptic force on the knob to indicate to the operator that the limit is being approached and/or has been reached. For example, when a maximum volume limit has been reached in a radio application, the haptic force can prevent the knob from rotating any further.

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Номер записи: 94
22-01-2015 дата публикации

SCREWLESS KNOB ASSEMBLY FOR TOYS

Номер: US20150020644A1
Автор: DuToit Wynand, Lipschitz Daniel Lester
Принадлежит: KidKraft, LP

A screwless knob assembly includes a knob member and a knob backcover member. The knob member includes a handle and a shaft. The shaft is disposed opposite the handle and is configured to communicate through an aperture of a backing board. A portion of the shaft is configured to extend completely through the aperture of the backing board. Furthermore, the knob backcover member is configured to securely fasten around the portion of the shaft. 1. An assembly comprising: a handle, and', 'a shaft disposed opposite the handle and configured to communicate through an aperture of a backing board, wherein a portion of the shaft is configured to extend completely through the aperture of the backing board; and, 'a knob member comprisinga knob backcover member configured to securely fasten around the portion of the shaft.2. The assembly of claim 1 , wherein the assembly is configured to permit unimpeded rotation when the knob member is coupled to the backing board.3. The assembly of claim 2 , wherein the unimpeded rotation comprises a clockwise rotation and a counterclockwise rotation.4. The assembly of claim 1 , wherein the assembly is configured to rotate in a clockwise direction and a counterclockwise direction when the knob member is coupled to the backing board without loosening or disengaging the knob member from the backing board.5. The assembly of claim 1 , further comprising a knob noise member configured to generate a noise when the shaft is rotated in the aperture of the backing board.6. The assembly of claim 5 , wherein the handle comprises one or more notches and the knob noise member comprises a notch engaging member claim 5 , wherein the one or more notches are configured to engage and subsequent disengage with the notch engaging member in order to generate the noise.7. The assembly of claim 6 , wherein the knob noise member is configured to abstain from rotating when the shaft is rotated in the aperture of the backing board so that the one or more notches ...

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Номер записи: 95
22-01-2015 дата публикации

SWITCH

Номер: US20150021150A1
Автор: Arihara Takeshi, Morimoto Masaru, Okayasu Yutaka, Washizu Tomoyuki
Принадлежит: Omron Corporation

A switch has a base having a frame portion disposed integrally with an outer peripheral portion of an upper surface of the base, a common fixed contact disposed at a corner of inside surfaces of the frame portion, and a fixed contact disposed on an inside surface of the base opposite to the common fixed contact, a spring member having elastic arm portions extending respectively from both ends of a bellows-like spring portion, wherein a free end portion of one of the elastic arm portions serves as a sliding movable contact, wherein a free end portion of another of the elastic arm portions serves as a rotationally movable contact, and wherein the rotationally movable contact is positioned so as to be in contact with the common fixed contact of the base, and an operation lever including an operation rib. 1. A switch comprising: a frame portion disposed integrally with an outer peripheral portion of an upper surface of the base,', 'a common fixed contact disposed at a corner of inside surfaces of the frame portion, and', 'a fixed contact disposed on an inside surface of the base opposite to the common fixed contact;, 'a base comprising elastic arm portions extending respectively from both ends of a bellows-like spring portion,', 'wherein a free end portion of one of the elastic arm portions serves as a sliding movable contact,', 'wherein a free end portion of another of the elastic arm portions serves as a rotationally movable contact, and', 'wherein the rotationally movable contact is positioned so as to be in contact with the common fixed contact of the base; and, 'a spring member comprisingan operation lever including an operation rib, which comes in contact with the one elastic arm portion of the spring member, and which is rotationally supported on the base,wherein, when the operation lever is rotated, the one elastic arm portion of the spring member is pushed down by the operation rib, whereby the bellows-like spring portion of the spring member is elastically ...

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Номер записи: 96
21-01-2016 дата публикации

SINGLE KNOB CONTROLLER

Номер: US20160021456A1
Автор: Dong Gu Wen, Hai Wang, Vansickle Larry
Принадлежит:

A single knob for controlling at least an audio input signal to produce up to fourteen distinct results, plus one quiescent state, through axial translational states corresponding to: the knob being translationally biased out, pushed in, or pushed in and held; and rotational states corresponding to: rotationally biased to a first position, turned clockwise, turned clockwise and held, turned counterclockwise, and turned clockwise and held, and combinations of those translational and rotational states. The single knob controller can be linked to a Bluetooth device for controlling such device. Some applications include automotive electronics and audio systems generally. 1. A single knob controller comprising:a. a knob capable of axial bi-directional translations and bi-directional rotation;b. an actuator coupled to said knob; andc. a circuit comprising said actuator responsive to said bi-directional axial translation, said bi-directional rotations, and to combinations of a translational state of said bi-directional axial translations and one said rotational state of said bi-directional rotations to produce one of fourteen distinct results.2. The single knob controller of claim 1 , wherein the system uses at least six results of said fourteen results claim 1 , said six results comprising:a. changing a selected track of an audio compilation source downward;b. changing a selected track of an audio compilation source upward;c. changing the volume of an audio output to a higher level;d. changing the volume of an audio output to a lower level;e. answering a phone call from a telephonic audio input device; andf. activating a voice command system.3. The single knob controller of claim 1 , wherein said circuit comprises a low drop out regulator claim 1 , logic circuitry claim 1 , an input jack and an output jack.4. The single knob controller of claim 1 , wherein said circuit is at least partially a printed circuit on an elongated circuit board and further comprising a threaded ...

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Номер записи: 97
22-01-2015 дата публикации

Multiple signaling hinged safety switch for mobile protection barriers

Номер: US20150022027A1
Автор: Giuseppe Pizzato, Marco Pizzato
Принадлежит: PIZZATO ELETTRICA SRL

A multi-signaling hinged safety switch for mobile protection barriers includes a fixed member designed to be secured to a stationary part of the barrier and having a pair of axial end holes, a movable member designed to be secured to a pivotal part of the barrier and having a pair of substantially transverse arms located outside the fixed member and pivoted to the axial end holes, an electrical detection system within the fixed member switching one or more electric safety circuits of the barrier at a predetermined switching angle. A pair of cylindrical pins extend in cantilever fashion from the arms and are pivotally inserted in the holes, with mutually spaced opposed ends defining a gap with no axial connection member therein. The detection system includes a pair of detectors each interacting with one end of a pin and having a switching angle that are operatively independent of each other.

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Номер записи: 98
28-01-2016 дата публикации

Mode Change Knob Assembly

Номер: US20160023344A1
Автор: Bernhart Ralf, Soika Martin
Принадлежит:

A knob assembly for a power tool comprising: a knob having a slot and knob recess, the slot and knob recess intersecting each other at an intersection within the knob; a latch slideably mounted within the slot; a peg located within the knob recess; wherein the peg and latch engage with each other via the intersection in order for the peg to retain the latch within the slot and for the latch to retain peg within the knob recess. 1. A knob assembly for a power tool comprising:a knob having a slot and a knob recess, the slot and knob recess intersecting each other at an intersection within the knob;a latch slideably mounted within the slot;a peg located within the knob recess;wherein the peg and latch engage with each other via the intersection in order for the peg to retain the latch within the slot and for the latch to retain peg within the knob recess.2. The knob assembly according to wherein the peg comprises a peg recess which faces towards the slot through the intersection;wherein the latch comprises a catch which locates in and is capable of sliding within the peg recess, the sliding movement of the latch within the slot being restricted by the sliding movement of the catch within the peg recess.3. The knob assembly according to wherein the latch comprises a resilient arm claim 2 , the catch being mounted on the resilient arm claim 2 , the resilient arm urging the catch into the peg recess.4. The knob assembly according to wherein the latch has the same width as the slot;wherein the resilient arm extends in a lengthwise direction on the latch;wherein the catch extends sideways from the resilient arm beyond the width of the latch through the intersection and into the peg recess.5. The knob assembly according to wherein the slot comprises a second recess formed within a side wall of the slot;wherein the latch comprises two resilient arms which extend in the same lengthwise direction, each arm having a catch mounted on it, each of which extend sideways beyond the ...

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Номер записи: 99
17-04-2014 дата публикации

ACTIVATION AND AGGREGATION OF HUMAN PLATELETS AND FORMATION OF PLATELET GELS BY NANOSECOND PULSED ELECTRIC FIELDS

Номер: US20140106430A1
Автор: BEEBE Stephen J., BLACKMORE Peter F., HARGRAVE Barbara Y., SCHOENBACH Karl H.
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Methods for forming activated platelet gels using nsPEF's and applying the activated gels to wounds, such as heart tissue after myocardial infarction. The platelets are activated by applying at least one nsPEF with a duration between about 10 picoseconds to 1 microsecond and electrical field strengths between about 10 kV/cm and 350 kV/cm. 1. A method of treating injured heart tissue , comprising: activating the concentrated platelets by applying at least one electrical pulse to the concentrated platelets,', 'wherein the electrical pulse has a duration of at least about 100 picoseconds and less than about 1 microsecond and an electric field strength of at least about 10 kV/cm and less than about 350 kV/cm; and applying the activated platelets to heart tissue., 'concentrating platelets;'}2. The method of wherein the injured heart tissue is due to myocardial infarction.3. The method of claim 1 , further comprising:reperfusing the heart tissue.4. The method of claim 1 , wherein the platelets are autologous.5. The method of claim 1 , wherein the electrical pulse has a duration of 300 nanoseconds and the electrical field strength is 30 kV/cm. This application is a divisional of U.S. application Ser. No. 13/129,076, §371 filing date of Aug. 5, 2011, which claims priority to PCT/US2009/064431 filed on Nov. 13, 2009, which claims priority to U.S. Provisional Application No. 61/114,363, filed Nov. 13, 2008, which are incorporated by reference in their entirety.Electric fields can be used to manipulate cell function in a variety of ways. One specific cell mechanism that can be affected by electric fields is calcium mobilization within a cell. Calcium signaling, an important cell function, is responsible for a variety of cellular responses and actions. The release of internally stored calcium can stimulate responses to agonists, activate growth and respiration, cause the secretion of neurotransmitters, activate transcription mechanisms, cause the release of a variety of ...

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