Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 5806. Отображено 100.
01-03-2012 дата публикации

Apparatus for Electrospray Ionization and Method for Electrospray Ionization Using the Same

Номер: US20120049082A1
Автор: Duk Jin Kang, Hyun Sik Kim, Jong Shin Yoo, Myoung Choul Choi
Принадлежит: Korea Basic Science Institute KBSI

An apparatus for electrospray ionization may include: a platform including an inlet port, a first channel connected to the inlet port, a second channel connected to the first channel, and an outlet port connected to the second channel; a nebulizer provided in the first channel and configured to spray inert gas to a sample sprayed into the first channel through the inlet port; and a focusing lens provided in the second channel and configured to focus ions produced from the sprayed sample toward the outlet port.

Подробнее
Номер записи: 1
31-01-2013 дата публикации

Method and apparatus for generating and analyzing ions

Номер: US20130026359A1
Автор: Li Ding, Sumio Kumashiro, Wenjian Sun
Принадлежит: Shimadzu Research Laboratory Shanghai Co Ltd

The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.

Подробнее
Номер записи: 2
18-04-2013 дата публикации

Mass distribution measuring method and mass distribution measuring apparatus

Номер: US20130092831A1
Автор: Koichi Tanji, Masafumi Kyogaku
Принадлежит: Canon Inc

To provide a method that reduces an influence of dependence of an ionizing beam in an incident direction or uneven irradiation to a sample on a result of mass spectrometry, and can measure mass distribution with high reliability. A mass distribution measuring method according to the present invention includes: changing a direction of irradiating the ionizing beam to a sample surface; acquiring a plurality of mass distribution images in a plurality of incident directions; performing image transform of the mass distribution images according to an angle formed by an incident direction of the ionizing beam and a substrate surface; synthesizing the plurality of transformed images; and outputting the synthesized mass distribution images.

Подробнее
Номер записи: 3
02-05-2013 дата публикации

TECHNIQUES FOR EFFICIENT FRAGMENTATION OF PEPTIDES

Номер: US20130105682A1
Автор: Chakraborty Asish B., Chen Welbin, Dorschel Craig A., Geromanos Scott J., Silva Jeffrey Cruz, Vissers Johannes P.C.
Принадлежит: WATERS TECHNOLOGIES CORPORATION

Techniques are described for performing mass spectrometry. A stream of one or more ions is generated. The stream is transmitted into a collision cell over a period of time. In accordance with a set of criteria including a retention time of one or more precursor ions, a collision energy of the collision cell is selected to generate one or more product ions for said one or more precursor ions in said stream. 1. A method for performing mass spectrometry comprising:generating a stream of one or more ions;transmitting said stream into a collision cell over a period of time; andselecting, in accordance with a set of criteria including a retention time of one or more precursor ions, a collision energy of the collision cell to generate one or more product ions for said one or more precursor ions in said stream.2. The method of claim 1 , wherein said collision energy is selected in accordance with one or more sets of data respectively associated with said one or more precursor ions claim 1 , each of said sets of data including a retention time claim 1 , a mass or m/z value claim 1 , and a charge state associated with one of said precursor ions.3. The method of claim 1 , wherein the period of time corresponds to an amount of time of an elevated energy scan associated with producing said one or more product ions from said one or more precursor ions.4. The method of claim 3 , wherein claim 3 , during said elevated energy scan claim 3 , said collision energy is varied from a minimum setting to a maximum setting.5. The method of claim 4 , wherein said collision energy is increased during said period of time from said minimum setting to said maximum setting claim 4 , and wherein said collision energy is increased linearly during said period of time.6. (canceled)7. The method of claim 3 , wherein said collision energy causes fragmentation of at least one ion.8. The method of claim 1 , wherein the period of time includes a first amount of time of a low energy scan during which ...

Подробнее
Номер записи: 4
02-05-2013 дата публикации

DISCONTINUOUS ATMOSPHERIC PRESSURE INTERFACE

Номер: US20130105683A1
Автор: Cooks Robert Graham, Gao Liang, Ouyang Zheng
Принадлежит:

A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure. 127-. (canceled)28. An analysis system , the system comprising:an ionizing source that generates a continuous flow of gas phase ions;a discontinuous atmospheric pressure interface that receives the gas phase ions from the ionizing source; anda mass analyzer of a miniature mass spectrometer that discontinuously receives ions from the discontinuous atmospheric pressure interface, the system being configured such that the mass analyzer is periodically prevented from receiving any ions.29. The system according to claim 28 , wherein the discontinuous atmospheric pressure interface comprises a valve.30. The system according to claim 29 , further comprising a computer operably connected to the system claim 29 , wherein the computer contains a processor configured to execute a computer readable program claim 29 , the program controlling the position of the valve.31. The system according to claim 29 , wherein the valve operates to control entry of ions in a synchronized manner with respect to operation of the mass analyzer.32. The system according to claim 28 , wherein the ionizing source operates by a technique selected from the group consisting of: electrospray ionization claim 28 , nano-electrospray ionization claim 28 , atmospheric pressure matrix-assisted laser desorption ionization claim 28 , atmospheric pressure chemical ionization claim 28 , ...

Подробнее
Номер записи: 5
09-05-2013 дата публикации

Method of Avoiding Space Charge Saturation Effects In An Ion Trap

Номер: US20130112865A1
Автор: Jason Lee Wildgoose, Martin Raymond Green
Принадлежит: Micromass UK Ltd

A mass spectrometer includes a first ion trap arranged upstream of an analytical second ion trap. The charge capacity of the first ion trap is set at a value such that if all the ions stored within the first ion trap up to the charge capacity limit of the first ion trap are then transferred to the second ion trap, then the analytical performance of the second ion trap is not substantially degraded due to space charge effects.

Подробнее
Номер записи: 6
16-05-2013 дата публикации

Methods and apparatuses for cleaning at least one surface of an ion source

Номер: US20130118523A1
Автор: John Allison
Принадлежит: Kratos Analytical Ltd

The present invention is concerned with methods and apparatus for cleaning the surface of an ion source in a mass spectrometer, for example an electrode of a MALDI ion source. The method includes directing UV light onto the surface to desorb contaminant material. The UV light source can be a laser and a moving reflecting surface can be used to direct the light on to the surface.

Подробнее
Номер записи: 7
13-06-2013 дата публикации

High-density sample support plate for automated sample aliquoting

Номер: US20130146758A1
Автор: Andrea Amantonico, Konstantins Jefimovs, Nils Goedecke, Pawel Urban, Renato Zenobi, Stephan Fagerer
Принадлежит: Eidgenoessische Materialprufungs und Forschungsanstalt EMPA, Eidgenoessische Technische Hochschule Zurich ETHZ

A sample support plate ( 100 ) for a variety of possible applications, including MALDI mass spectrometry, is disclosed. A plurality of spatially separated sample recipient sites ( 101 ) are arranged on the surface of a substrate. The recipient sites are mutually separated by areas having a different wettability than the recipient sites. They are arranged in a plurality of rows consisting of a plurality of recipient sites whose centers are regularly spaced along a first direction with a predetermined periodicity (D 1 ), the rows being regularly spaced along a second direction perpendicular to the first direction with a predetermined centerline distance (D 2 ). Each recipient site has a maximum lateral dimension that is preferably smaller than the diameter of a beam spot ( 104 ) of a desorption laser beam ( 103 ). In order to enable unsupervised splitting of bulk liquid samples into droplets at the sample recipient sites, the periodicity along the first direction and the centerline distance along the second direction are chosen such that each recipient sites has a next neighbor at a distance that is less than or equal to three times the minimum lateral dimension of each recipient site. In preferred embodiments, the sample recipient sites are arranged in a checkerboard-type pattern or in rows that are inclined relative to the edges of the sample support plate.

Подробнее
Номер записи: 8
20-06-2013 дата публикации

METHOD AND APPARATUS FOR IONIZING GASES USING UV RADIATION AND ELECTRONS AND IDENTIFYING SAID GASES

Номер: US20130153762A1
Автор: Münchmeyer Wolf, Ungethüm Bert, Walte Andreas
Принадлежит: AIRSENSE ANALYTICS GMBH

The invention relates to a method for ionizing and identifying gases, wherein the gases to be identified are ionized in a reaction chamber and the product ions are measured, wherein the measurement of the product ions takes place via electrical fields acting on the product ions and the detection is performed with a detector for ions. It is provided that ionization takes place via UV radiation, and that simultaneously or sequentially ionization by electrons takes place. The invention further relates to a device for ionizing and identifying gases, which includes an ion source chamber having an ion source and an ion mobility spectrometer. For this purpose, a partition between the ion source chamber and the ion mobility spectrometer has a UV-transparent window and a window permeable for electrons, wherein UV radiation and electron radiation can be generated in the ion source chamber with the ion source. 1. Method for identifying and ionizing gases , wherein the gases to be identified are ionized in a reaction chamber and the product ions are measured , wherein the measurement of the product ions takes place by exposing the product ions to electric fields and the detection is performed with a detector for ions , wherein the ionization is performed using UV radiation , and that simultaneously or sequentially an ionization with electrons is performed.2. Method according to claim 1 , wherein the ionization is performed by accelerating the electrons electrically in a low pressure region and accelerating the electrons towards an electron window which is permeable for electrons claim 1 , wherein the electrons penetrate the window and then generate ions in a high pressure region.3. Method according to claim 1 , wherein the ionization is performed indirectly by accelerating the electrons electrically in a low pressure region and accelerating the electrons towards an electron window claim 1 , where the electrons are strongly decelerated and produce bremsstrahlung claim 1 , which ...

Подробнее
Номер записи: 9
01-08-2013 дата публикации

ION SOURCE FOR MASS SPECTROMETERS

Номер: US20130193318A1
Автор: HANSEN Stuart C., LAND Adrian
Принадлежит: AGILENT TECHNOLOGIES, INC.

Ion sources for use in mass spectrometry (MS) systems are described. The ion sources each comprise an ion funnel and an ionization source configured to ionize neutral analyte molecules. 1. An ion source , comprising:an ion funnel comprising a first opening at a first end and a second opening at a second end, the first opening configured to receive neutral analyte molecules; andan ionization device configured to ionize the neutral analyte molecules in the ion funnel.2. An ion source as claimed in claim 1 , further comprising an inlet capillary configured to deliver the neutral analyte molecules to the first opening claim 1 ,3. An ion source as claimed in claim 2 , wherein the inlet capillary is in fluid communication with a gas chromatograph.4. An ion source as claimed in claim 1 , wherein the ionization device comprises one of: an electromagnetic radiation source and an electron source.5. An ion source as claimed in claim 4 , wherein the electromagnetic radiation source comprises a vacuum ultraviolet (VUV) radiation source.6. An ion source as claimed in claim 5 , wherein the VUV source comprises one of:a microplasma VUV source, an excimer VUV source, a direct current (DC) excited gas discharge source, an alternating current (AC) excited gas discharge source, or a laser source.7. An ion source as claimed in claim 5 , wherein the VUV source is positioned so that photons from the VUV source interact with the neutral analyte molecules inside the ion funnel.8. An ion source as claimed in claim 7 , wherein the VUV source is a first VUV source claim 7 , and the ion source further comprises a second VUV source claim 7 , the first VUV source and the second VUV source each being positioned at an angle relative to an axis of symmetry of the ion funnel.9. An ion source as claimed in claim 8 , further comprising a third VUV source and a fourth VUV source each positioned so that photons from the second VUV source claim 8 , the third VUV source and the fourth VUV source interact ...

Подробнее
Номер записи: 10
15-08-2013 дата публикации

TIME-OF-FLIGHT MASS SPECTROMETER WITH ACCUMULATING ELECTRON IMPACT ION SOURCE

Номер: US20130206978A1
Автор: Khasin Yuri, Verenchikov Anatoly N.
Принадлежит: LECO Corporation

An accumulating ion source for a mass spectrometer that includes a sample injector () introducing sample vapors into an ionization space () and an electron emitter () emitting a continuous electron beam () into the ionization space () to generate analyte ions. The accumulating ion source further includes first and second electrodes () arranged spaced apart in the ionization space () for accumulating analyte ions substantially therebetween. The first and second electrodes () receive periodic extraction energy potentials to accelerate packets of analyte ions from the ionization space () along a first axis. An orthogonal accelerator () receives the packets of analyte ions along the first axis and periodically accelerates the packets of analyte ions along a second axis substantially orthogonal to the first axis. A time delay between the extraction acceleration and the acceleration of each respective packet of analyte ions provides a proportional mass range of the respective packet of analyte ions. 1. An ion source for a time-of-flight mass spectrometer , the ion source comprising:{'b': 328', '115, 'a sample injector () introducing sample vapors into an ionization space ();'}{'b': 102', '104', '115, 'an electron emitter () providing a continuous electron beam () into the ionization space () to generate one or more packets of analyte ions; and'}{'b': '140', 'an orthogonal accelerator () receiving the packets of analyte ions along the first axis and periodically accelerating the packets of analyte ions along a second axis that is substantially orthogonal to the first axis;'}{'b': 108', '108', '115', '104', '108', '108', '115, 'i': a,', 'b', 'a,', 'b, 'wherein for the purpose of enhancing sensitivity and resolution, first and second electrodes () arranged spaced apart in the ionization space () for accumulating analyte ions within the electron beam (), the first and second electrodes () receiving periodic extraction pulsed potentials to accelerate packets of analyte ions ...

Подробнее
Номер записи: 11
15-08-2013 дата публикации

Laser-Ablation Ion Source with Ion Funnel

Номер: US20130207000A1
Автор: Bodo Hattendordf, Detlef Günther, Rolf Dietiker, Tatiana Egorova, Victor Varentsov
Принадлежит: Eidgenoessische Technische Hochschule Zurich ETHZ

A laser-ablation ion source for generating a low energy ion beam having low longitudinal and transverse emittance, including a supersonic nozzle, followed by an RF ion funnel. A laser source generates a laser beam which is focused by a lens to an ablation site. The ablation site is located upstream of the nozzle, at a distance of less than 10 mm from the nozzle aperture. The laser irradiates the ablation site through the nozzle aperture to generate the ions.

Подробнее
Номер записи: 12
22-08-2013 дата публикации

GENERATOR APPARATUS FOR PRODUCING VORTEX RINGS ENTRAINED WITH CHARGED PARTICLES

Номер: US20130214054A1
Автор: Dvorsky James E., Faulkner Lynn L.
Принадлежит: BATTELLE MEMORIAL INSTITUTE

A process is provided for dispersing suspended particles in the air comprising: providing a generator apparatus for producing one or more propagating fluid vortex rings transporting ionized particles; directing the generator apparatus in a direction toward suspended particles in the air to be dispersed; generating a fluid vortex ring transporting ionized particles using the generator apparatus such that the fluid vortex ring travels to the suspended particles resulting in at least a portion of the ionized particles engaging and applying a charge to at least a portion of the suspended particles. The charged suspended particles are then attracted to one another or to nearby surfaces.

Подробнее
Номер записи: 13
22-08-2013 дата публикации

Laser ablation electrospray ionization (laesi) for atmospheric pressure, in vivo, and imaging mass spectrometry

Номер: US20130214150A1
Автор: Akos Vertes, Peter Nemes
Принадлежит: George Washington University

The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI)

Подробнее
Номер записи: 14
22-08-2013 дата публикации

DEVICES AND SYSTEMS INCLUDING A BOOST DEVICE

Номер: US20130214153A1
Автор: Morrisroe Peter
Принадлежит:

A device for mass spectroscopy comprising a chamber configured to provide an atomization source, a boost device configured to provide radio frequency energy to the chamber, and a mass analyzer in fluid communication with the chamber and configured to separate species based on mass-to-charge ratios is disclosed. In certain examples, a boost device may be used with a flame or plasma to provide additional energy to a flame or plasma to enhance desolvation, atomization, and/or ionization.

Подробнее
Номер записи: 15
22-08-2013 дата публикации

SYSTEM AND METHOD FOR IONIZATION OF MOLECULES FOR MASS SPECTROMETRY AND ION MOBILITY SPECTROMETRY

Номер: US20130214154A1
Автор: McEwen Charles Nehemiah, Pagnotti Vincent Salvatore, Trimpin Sarah
Принадлежит:

An ionizing system includes a channel having an inlet disposed in a first pressure region and an outlet disposed in a second pressure region, a pressure of the first pressure region being greater than a pressure of the second pressure region. A heater is coupled to the channel and configured to heat the channel. A device is configured to introduce an analyte into the channel where the analyte is ionized. 1. An ionizing system , comprising:a channel having an inlet disposed in a first pressure region and an outlet disposed in a second pressure region, a pressure of the first pressure region being greater than a pressure of the second pressure region;a heater coupled to the channel and configured to heat the channel; anda device for introducing an analyte into the channel where the analyte is ionized.2. The ionizing system of claim 1 , wherein the channel is defined by a transfer tube that is coupled to the heater such that the transfer tube is heated by the heater.3. The ionizing system of claim 1 , wherein the channel is defined by the heater.4. The ionizing system of claim 3 , wherein a skimmer is disposed over the inlet of the channel and defines an opening that is in fluid communication with the channel.5. The ionizing system of claim 1 , wherein the device is a substrate on which the analyte is disposed.6. The ionizing system of claim 5 , wherein the substrate is disposed adjacent to the inlet of the channel and is configured to be contacted by one of a physical object or electromagnetic energy.7. The ionizing system of claim 1 , wherein the analyte is mixed with a matrix.8. The ionizing system of claim 1 , wherein the device includes:a container in which a solution including the analyte is disposed;a conduit having a first end disposed in the container such that the first end is in contact with the solution including the analyte and a second end disposed adjacent to or within the inlet of the channel.9. The ionizing system of claim 8 , further comprising an ...

Подробнее
Номер записи: 16
29-08-2013 дата публикации

Fragmentation Methods for Mass Spectrometry

Номер: US20130221233A1
Автор: Cousins Lisa, Javahery Gholamreza, Rakov Sergey, Welkie David G., Whitehouse Craig M.
Принадлежит: PerkinElmer Health Sciences, Inc.

Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided. 1. An apparatus for fragmenting ions of sample substances , comprising:(a) a first multipole ion guide comprising a set of rods parallel to each other and spaced about an ion guide axis, the first multipole ion guide having an entrance end and an exit end;(b) an electron source arranged downstream of the entrance end of the first multipole ion guide, the electron source configured to produce low-energy electrons;(c) a first enclosure arranged upstream of the entrance end of the first multipole ion guide, the first enclosure enclosing a second multipole ion guide, the second multipole ion guide having an entrance end and an exit end; and(d) one or more lenses configured to direct low-energy electrons from the electron source to a region proximal to the ion guide axis between the exit end of the second multipole ion guide ...

Подробнее
Номер записи: 17
05-09-2013 дата публикации

MASS SPECTROMETER AND MASS SPECTROMETRY METHOD

Номер: US20130228682A1
Автор: YASUDA Hiroyuki, Yoshioka Shinji
Принадлежит: HITACHI HIGH-TECHNOLOGIES CORPORATION

A mass spectrometer is provided including: a collision chamber of generating fragment ions by superimposingly applying an AC voltage and a first DC voltage between linear multipolar electrodes, and accelerating the fragment ions by applying a second DC voltage between a front stage electrode and a later stage electrode; a mass spectrometer unit of carrying out mass separation of the fragment ions; and a control unit of determining the second DC voltage based on the mass-to-charge ratios such that the rates of the fragment ions in the collision chamber become equal regardless of the mass-to-charge ratios. Herein, the control unit increases the second DC voltage as the mass-to-charge ratios selected by the mass spectrometer unit become larger. This allows the mass window to be wider even when a DC electric field is generated in order to solve a crosstalk drawback, in the movement direction of the molecular ions. 1. A mass spectrometer comprising:a collision chamber including linear multipolar electrodes, and accelerates fragment ions in a direction along the linear multipolar electrodes by superimposingly applying an AC voltage for collision and a first DC voltage between the linear multipolar electrodes, having a molecule ion collide with a neutral molecule to cause collision induced dissociation of the molecule ion and to generate the fragment ions, and applying a second DC voltage between a front stage electrode and a later stage electrode which are divided from each linear multipolar electrode;a mass spectroscopy unit carrying out mass separation of the fragment ions with mass-to-charge ratios, the fragment ions accelerated in the collision chamber; anda control unit determining the second DC voltage based on the mass-to-charge ratios of the fragment ions to be selected in the mass spectroscopy unit such that velocities of the fragment ions in the collision chamber become equal regardless of the mass-to-charge ratios of the fragment ions.2. The mass spectrometer ...

Подробнее
Номер записи: 18
26-09-2013 дата публикации

Method for isotopic measurement by icpms

Номер: US20130248365A1
Автор: Frederic Chartier, Gerard Cretier, Laurent Vio, Valérie Geersten
Принадлежит: Commissariat a lEnergie Atomique et aux Energies Alternatives CEA

A method for isotope measurement of charged species contained in a solution to be analyzed, particularly charged species having an isobaric interference, has the following consecutive steps: a) in the capillary of a capillary electrophoresis device, the solution to be analyzed is inserted contiguously between a terminating electrolyte and a leading electrolyte that, respectively, are placed after the inlet and before the outlet of the capillary and contain ions of the same charge but with mobility inferior and superior to those of said species; b) separating the species by using the capillary electrophoresis device according to the isotachophoresis mode; then c) in the continuity of the preceding step, performing an isotope measurement of the species detected in the form of a substantially constant amplitude signal by using an inductively coupled plasma mass spectrometer (ICPMS) connected by direct coupling with the capillary electrophoresis device.

Подробнее
Номер записи: 19
26-09-2013 дата публикации

Mass Spectrometer Arranged to Perform MS/MS/MS

Номер: US20130248704A1
Автор: Kenny Daniel James
Принадлежит: MICROMASS UK LIMITED

A mass spectrometer is disclosed comprising an ion trap and a fragmentation device. Ions are fragmented in the ion trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyser for subsequent mass analysis. 1. A method of mass spectrometry comprising:accumulating ions within an ion trap;isolating ions of interest within said ion trap;fragmenting at least some of said ions of interest within said ion trap to form a plurality of first fragment ions;transferring at least some of said first fragment ions to a fragmentation device which is arranged either upstream or downstream of said ion trap; andfragmenting at least some said first fragment ions within said fragmentation device to form a plurality of second fragment ions.2. A method as claimed in claim 1 , wherein said ion trap is operated in a mode of operation and has an effective first low mass or mass to charge ratio cut-off and wherein said fragmentation device is operated in a mode of operation and has an effective second low mass or mass to charge ratio cut-off claim 1 , wherein said second low mass or mass to charge ratio cut-off is substantially lower than said first low mass or mass to charge ratio cut-off.3. A method as claimed in claim 1 , wherein said ion trap comprises a different number of electrodes or is structurally different to said fragmentation device so that for ions having a particular mass to charge ratio said ion trap has a first low mass cut-off and said fragmentation device has a second different low mass cut-off.4. A method as claimed in claim 1 , wherein said ion trap comprises a first plurality of electrodes having a first spacing or ...

Подробнее
Номер записи: 20
10-10-2013 дата публикации

SELECTIVE IONIZATION USING HIGH FREQUENCY FILTERING OF REACTIVE IONS

Номер: US20130264475A1
Автор: Boumsellek Said, Ivashin Dmitriy V.
Принадлежит: Implant Sciences Corporation

Selective ionization at atmospheric or near atmospheric pressure of a sample diluted in air is provided in multiple steps. Initially, components of air and/or other gas are ionized to generate reactive ions. The reactive ions are then filtered using a high frequency filter to yield selected reactive ions. Thereafter, the selected reactive ions are reacted with sample molecules of a sample being analyzed in a charge transfer process. Depending on the properties of the sample molecules, the filter may select some reactive ions to enter the sample zone and block others entirely thus controlling ion chemistry and charge transfer yields in the sample zone. The described system is directed to controlling ions at the ion source level, using a high frequency filter technique, in connection with subsequent analysis. The method generates the ions of choice for subsequent analysis in such platforms as ion mobility and differential mobility spectrometers. 1. A selective ionization device , comprising:an ionization zone in which reactive ions are generated, the reactive ions being generated from a gas that is separate from a sample being analyzed;a sample zone that contains the sample being analyzed; anda high frequency filter that receives the reactive ions propelled from the ionization zone and delivers selected reactive ions to the sample zone, wherein the reactive ions from the ionization zone are selectively filtered via control of electrodes of the high frequency filter to generate the selected reactive ions, wherein, in the sample zone, the selected reactive ions react with the sample molecules of the sample being analyzed in a charge transfer process.2. The selective ionization device according to claim 1 , wherein the high frequency filter includes a high field asymmetric waveform ion mobility spectrometer (FAIMS).3. The selective ionization device according to claim 1 , further comprising:an analysis platform that analyzes sample ions of interest following the charge ...

Подробнее
Номер записи: 21
17-10-2013 дата публикации

Use of detector response curves to optimize settings for mass spectrometry

Номер: US20130274143A1
Автор: Brian M. Gurbaxani, II Vincent A. Emanuele
Принадлежит: US Department of Health and Human Services

Processes for identifying optimal mass spectrometer settings to produce the greatest confidence in sample constituent detection are provided. Data obtained on a mass spectrometer are analyzed by a quadratic variance function which accurately represents intensity variation as a variation of peak intensity. This function is then used to identify intensities that possess a minimum coefficient of variation that is useful for identifying optimal mass spectrometer settings. Inventive processes involve using a general purpose computer to identify optimal mass spectrometer settings for use in biomarker analyses, for optimizing peak detection and biomarker identification in a biological sample. The inventive processes provide for improved methods of identifying new biomarkers as well as screening subjects for the presence or absence of disease or biological condition.

Подробнее
Номер записи: 22
14-11-2013 дата публикации

Ion Source With Surface Coating

Номер: US20130299691A1
Автор: Amir Farooq, David S. Douce, Gordon A. Jones
Принадлежит: Micromass UK Ltd

A mass spectrometer includes an Electron Impact (“EI”) or a Chemical Ionisation (“CI”) ion source, and the ion source includes a first coating or surface. The first coating or surface is formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal.

Подробнее
Номер записи: 23
14-11-2013 дата публикации

MASS SPECTROMETRY METHOD, ION PRODUCTION DEVICE, AND MASS SPECTROMETRY SYSTEM

Номер: US20130299692A1
Автор: Kinoshita Kazumasa, Nakatani Yoshimasa, Noritake Yuka, Shida Yasuo, Shimada Haruo
Принадлежит:

A mass spectrometry method of the present invention is such that a sample is heated to generate a gas and an ion that is produced from the gas is introduced into a mass spectrometer by using DART so that mass spectrometry is conducted. 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. (canceled)13. A mass spectrometry method , comprising:heating a sample to generate a gas;producing an ion from the gas by using DART; andintroducing the ion into a mass spectrometer.14. The mass spectrometry method as claimed in claim 13 , wherein the heating of the sample includes applying a voltage to a resistance heating wire.15. The mass spectrometry method as claimed in claim 14 , wherein the heating of the sample further includes putting the sample into a pot wrapped with the resistance heating wire.16. The mass spectrometry method as claimed in claim 14 , wherein the heating of the sample further includes attaching the sample to the resistance heating wire.17. A mass spectrometry method claim 14 , comprising:heating a sample;producing an ion from the sample by using DART; andintroducing the ion into a mass spectrometer.18. The mass spectrometry method as claimed in claim 17 , wherein the heating of the sample includes attaching the sample to the resistance heating wire and applying a voltage to the resistance heating wire.19. An ion production device claim 17 , comprising:a heating device configured to heat a sample to generate a gas; anda DART ion source configured to produce an ion from the gas.20. The ion production device as claimed in claim 19 , wherein the heating device includes a pot configured to put the sample therein claim 19 , the pot is wrapped with a resistance heating wire claim 19 , and the heating device further includes a voltage applying device configured to apply a voltage to the resistance heating wire.21. The ion production device as claimed in claim 19 , ...

Подробнее
Номер записи: 24
19-12-2013 дата публикации

Ionization method, mass spectrometry method, extraction method, and purification method

Номер: US20130334030A1
Автор: Ryuichi Arakawa, Yoichi Otsuka
Принадлежит: Canon Inc, KANSAI UNIVERSITY

The present invention has an object to achieve soft ionization more easily when a slight amount of substance is ionized under an atmosphere pressure. The present invention provides an ionization method for a substance contained in a liquid, including: supplying the liquid to a substrate from a probe and forming a liquid bridge made of the liquid containing the substance dissolved therein, between the probe and the substrate; oscillating the substrate; and generating an electric field between an electrically conductive portion of the probe in contact with the liquid and an ion extraction electrode.

Подробнее
Номер записи: 25
19-12-2013 дата публикации

MASS SPECTROMETER AND ION SOURCE USED THEREFOR

Номер: US20130334416A1
Автор: Hasegawa Hideki, Hashimoto Yuichiro, Satake Hiroyuki, Sugiyama Masuyuki
Принадлежит: HITACHI HIGH-TECHNOLOGIES CORPORATION

The quantitative accuracy of analysis is improved without reducing the dynamic range for measurement of concentrations by performing stable ionization through electrospray or the like which repeats sampling and ionization using a movable probe electrode. 1. A mass spectrometer comprising: an ion source; a mass spectrometer section having a counter electrode provided with an inlet through which an ionized sample is introduced; and a control section that controls the ion source , whereinthe ion source includes:a sample retaining section that retains a sample;a sample transport electrode that has a plurality of probe electrodes;a power source that applies a voltage between the sample transport electrode and the counter electrode; anda driving section that drives the sample transport electrode such that the plurality of probe electrodes sequentially pass by the sample retaining section and the inlet.2. The mass spectrometer according to claim 1 , whereinthe sample transport electrode includes a disk electrode that rotates about a rotation axis, and has a structure in which the plurality of probe electrodes are provided in a peripheral portion of the disk electrode such that each tip end faces toward a direction perpendicular to the plane of the disk electrode, and the axial direction of the rotation axis faces toward a direction substantially parallel to the stream of ions introduced from the tip end of the probe electrode into the inlet.3. The mass spectrometer according to claim 1 , whereinthe sample transport electrode includes a disk electrode that rotates about a rotation axis, and has a structure in which the plurality of probe electrodes are radially provided in the in-plane direction of the disk electrode, and the axial direction of the rotation axis faces toward a direction substantially perpendicular to the direction of the stream of ions introduced from the tip end of the probe electrode into the inlet.4. The mass spectrometer according to claim 1 , ...

Подробнее
Номер записи: 26
02-01-2014 дата публикации

METHOD FOR THE DIELECTRIC BARRIER ELECTROSPRAY IONIZATION OF LIQUID SAMPLES AND FOR THE SUBSEQUENT MASS SPECTROMETRIC ANALYSIS OF THE GENERATED SAMPLE IONS

Номер: US20140001352A1
Автор: Franzke Joachim, JANASEK Dirk, Jestel Guenter, Meyer Cordula, Schilling Michael, Stark Ann-Kathrin, Wilberg Ruediger
Принадлежит:

The invention relates to a method for the dielectric barrier electrospray ionization of liquid samples and for the subsequent mass spectrometric analysis of the generated sample ions, in which the respective liquid sample is conducted in a capillary-shaped feed channel, the surrounding wall of which comprises on the outer side, spaced from the free end, an electrode which is separated from the wall by a separating layer made of a dielectric material, wherein at a distance from the free end of the feed channel an inlet of a mass spectrometer forming a counter electrode is arranged, creating an ion formation clearance, the formed ions reaching an openable and closable trap of the mass spectrometer through the inlet, wherein a square-wave voltage is applied between the electrode and the inlet for generating the sample ions and the trap of the mass spectrometer is alternately opened and closed, and wherein the sample ions reaching the trap of the mass spectrometer are analyzed in the mass spectrometer. The aim of the invention is to only have positive or negative sample ions reach the mass spectrometer while preserving the advantages of applying a square-wave voltage. The aim is achieved by applying an asymmetrical square-wave voltage between the electrode and the inlet, in which voltage the frequency ratio of the positive and negative polarities is different. 1. Method for dielectric barrier electrospray ionization of liquid samples and for subsequent mass spectrometric analysis of the generated sample ions , in which method the liquid sample , in each instance , is conducted in a capillary-shaped feed channel , the surrounding wall of which comprises , on the outer side , at a distance from the free end , an electrode separated from the wall by a separating layer composed of a dielectric material , wherein an inlet of a mass spectrometer , forming a counter-electrode , is disposed at a distance from the free end of the feed channel , with the creation of an ion ...

Подробнее
Номер записи: 27
09-01-2014 дата публикации

NANOPHOTONIC PRODUCTION, MODULATION AND SWITCHING OF IONS BY SILICON MICROCOLUMN ARRAYS

Номер: US20140008528A1
Автор: Vertes Akos, WALKER Bennett N.
Принадлежит: The George Washington University

The production and use of silicon microcolumn arrays that harvest light from a laser pulse to produce ions are described. The systems of the present invention seem to behave like a quasi-periodic antenna array with ion yields that show profound dependence on the plane of laser light polarization and the angle of incidence. By providing photonic ion sources, this enables enhanced control of ion production on a micro/nano scale and direct integration with miniaturized analytical devices. 1. A mass spectrometry system for controlling fragmentation and ion production from a sample , the system comprising:a pulsed laser source;a polarizer capable of plane polarizing radiation from the laser source and rotating the angle of plane polarized radiation from the laser source between an angle of s-polarized radiation and an angle of p-polarized radiation;an array for receiving the sample, the array being made from a semiconductor material and having quasi-periodic columnar structures; anda mass spectrometer for detecting ions formed from the sample;wherein when the radiation from the pulsed laser source is rotated so that when the angle of the plane polarization of the laser source approaches the angle of p-polarized radiation, the fragmentation and ion production from the sample is increased, and when the angle of the plane polarization of the laser source approaches the angle of s-polarized radiation, the fragmentation and ion production from the sample is decreased.2. The system of claim 1 , wherein the semiconductor material is selected from the group consisting of: p-type or n-type silicon claim 1 , germanium and gallium arsenide at various doping levels.3. The system of claim 1 , wherein the array is a laser-induced silicon microcolumn array.4. The system of claim 3 , wherein the columnar structures have a height of about 1 to 5 times the wavelength of the radiation claim 3 , a diameter equal to about one wavelength of the radiation claim 3 , and a lateral periodicity of ...

Подробнее
Номер записи: 28
09-01-2014 дата публикации

METHOD AND SUBSTRATES FOR FORMING CRYSTALS

Номер: US20140008546A1
Автор: BALIKA Werner, MAURACHER Christoph, NAISBY Andrew
Принадлежит: SONY DADC AUSTRIA AG

A structured substrate is described which is suitable for forming and hosting a crystal array, as well as associated methods for making and using such a structured substrate. The structured substrate is made by injection molding and has on one side a combination of macro- and micro-structured features. Each macro-structured feature comprises an edge that forms a perimeter around an enclosed area containing a large number of the micro-structured features. When a droplet of a solution containing molecules of interest and a solvent is deposited onto one of the enclosed areas such that it extends somewhat beyond the perimeter, the droplet slowly dries and shrinks through evaporation of the solvent, during which the edge acts to seed crystallization of the molecules, and the micro-structured features act to direct crystal growth from the seed into the enclosed area. The crystal thus forms over the whole of the enclosed area in a shape that conforms to the perimeter. Crystals of a desired size and shape can therefore be formed. 1. A method of forming a crystal array on a structured substrate comprising:providing a structured substrate having on one side a combination of macro-structured features and micro-structured features, each macro-structured feature comprising an edge that forms a perimeter around an enclosed area containing a large number of the micro-structured features;depositing on one of the enclosed areas a droplet of a solution containing molecules of interest and a solvent, wherein the volume of the solution deposited is controlled to ensure the droplet initially overfills the enclosed area to extend laterally beyond the perimeter onto adjacent surface portions;forming a crystal substantially confined to the enclosed area by allowing the droplet to dry and shrink through evaporation of the solvent, during which the edge acts to seed crystallization of the molecules at one or more locations on the perimeter and the micro-structured features act to direct ...

Подробнее
Номер записи: 29
30-01-2014 дата публикации

Systems and Methods Extending the Laserspray Ionization Mass Spectrometry Concept from Atmospheric Pressure to Vacuum

Номер: US20140027631A1
Автор: Trimpin Sarah
Принадлежит: WAYNE STATE UNIVERSITY

Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry. 1. A method of producing multiply-charged analyte ions from a matrix/analyte association comprisingcontacting the matrix/analyte association with a force that generates transfer and receipt of charge between the matrix and analyte;allowing the matrix/analyte association to enter the gas phase of an ion source of a mass spectrometer wherein the gas phase comprises an intermediate pressure zone or a high vacuum zone such that the matrix/analyte association is exposed to a decrease in pressurethereby producing the multiply-charged analyte ions.2. A method of wherein the gas phase comprises an intermediate pressure zone with a pressure from about 10Torr to about 200 Torr.3. A method of wherein the gas phase comprises a high vacuum zone with a pressure from about 10Torr to about 10Torr.4. A method of wherein the method further comprises heating an ionization region comprising a sample stage on which the matrix/analyte association is contacted with the force.5. A method of wherein the force is a laser beam.6. A method of wherein the laser beam contacts the matrix/analyte association through transmission geometry or through reflection geometry.7. A method of wherein the matrix is an organic composition that comprises a compound of Scheme 1.8. A method of wherein the analyte is an intact claim 1 , enzymatically digested claim 1 , oxidized claim 1 , acetylated claim 1 , methylated claim 1 , sulfonated claim 1 , or phosphorylated protein or peptide.9. A method of wherein the oxidation claim 8 , acetylation or phosphorylation of the protein or peptide is indicative of a disease state.10. A method of wherein the ...

Подробнее
Номер записи: 30
20-02-2014 дата публикации

SCREEN INSERT FOR A POWDER CHAMBER OF A POWDER SUPPLYING DEVICE

Номер: US20140048015A1
Автор: Mauchle Felix, Seinemann Mark
Принадлежит: Gema Switzerland GmbH

The invention relates to a screen insert () for a powder container () of a powder supplying device, the screen insert () having a screen unit () for screening coating powder and an ultrasonic transducer () for generating ultrasonic vibrations. The screen unit () is connected to the ultrasonic transducer () in such a way that the ultrasonic vibrations generated by the ultrasonic transducer () can be transferred to the screen unit (). To allow a particularly compact construction of the screen insert () to be achieved, according to the invention a screen carrier () which can be placed onto the powder container () is provided, for holding the ultrasonic transducer (), with the screen unit () connected thereto, in such a way that the screen unit () is arranged below the screen carrier (), so that the screen unit () is inside a powder chamber (), formed by the powder container (), when the screen carrier () has been placed onto the powder container (). 1. A screen insert for a powder container of a powder supplying device , the screen insert having a screen unit for screening coating powder and an ultrasonic transducer for generating ultrasonic vibrations , the screen unitbeing connected to the ultrasonic transducerin such a way that the ultrasonic vibrations generated by the ultrasonic transducer can be transferred to the screen unit,whereina screen carrier which can be placed onto the powder container is also provided, for holding the ultrasonic transducer, with the screen unit connected thereto, in such a way that the screen unit is arranged below the screen carrier, so that the screen unit is inside a powder chamber, formed by the powder container, when the screen carrier has been placed onto the powder container.2. The screen insert as claimed in claim 1 , the screen unit being connected to the ultrasonic transducer by way of an angle connection.3. The screen insert as claimed in claim 1 , a fastening device also being provided claim 1 , in particular a quick-action ...

Подробнее
Номер записи: 31
20-02-2014 дата публикации

METHOD AND SYSTEM FOR SIMULTANEOUSLY FINDING AND MEASURING MULTIPLE ANALYTES FROM COMPLEX SAMPLES

Номер: US20140048699A1
Автор: BARNES Christopher, Lo Edward, Ratner Buddy D., Stein M. Jeanette
Принадлежит: University of Washington through its Center for Commercialization

Method and system for detecting multiple analytes from a sample material by desorption ionization, mass analysis, and multivariate statistical analysis. 1. A method for detecting analytes in a sample material , comprising:(a) generating analyte particles by ambient desorptive ionization of a sample material;(b) analyzing the analyte particles with a mass analyzer to provide a mass spectrum of the analyte particles from a mixed sample; and(c) determining the presence of the analytes in the sample material by multivariate statistical analysis of the mass spectrum.2. The method of claim 1 , wherein generating analyte particles by ambient desorption ionization comprises contacting the sample material with a plasma.3. The method of claim 2 , wherein the plasma is a low temperature plasma.4. The method of claim 1 , wherein generating analyte particles by ambient desorption ionization comprises contacting the sample material with a desorption electrospray ionization source claim 1 , a paper spray ionization source claim 1 , a desorption sonic spray ionization source claim 1 , a desorption atmospheric pressure photoionization source claim 1 , a direct analysis in real time source claim 1 , an atmospheric solids analysis probe source claim 1 , a desorption atmospheric pressure chemical ionization source claim 1 , a dielectric barrier discharge ionization source claim 1 , a plasma-assisted desorption/ionization source claim 1 , a neutral desorption sampling extractive electrospray ionization source claim 1 , an electrospray-assisted laser desorption ionization source claim 1 , a laser ablation-electrospray ionization source claim 1 , a matrix-assisted laser desorption electrospray ionization source claim 1 , or an infrared laser-assisted desorption electrospray ionization source.5. The method of claim 1 , wherein the analyte particle is a positive ion.6. The method of claim 1 , wherein the analyte particle is a negative ion.7. The method of claim 1 , wherein the mass analyzer ...

Подробнее
Номер записи: 32
06-03-2014 дата публикации

Atmospheric pressure ion source with exhaust system

Номер: US20140061500A1
Автор: Roy P. Moeller, Stephen Zanon, Zicheng Yang
Принадлежит: Bruker Daltonics Inc

An atmospheric pressure ion source, employing the principle of electrospray ionization, chemical ionization, or photo-ionization, comprises a spray probe for spraying a liquid into an ionization chamber and has an exhaust port through which residual spray mist and waste gas, such as evaporated solvent, are extracted. The ion source further comprises an exhaust system comprising a conduit which is connected to the exhaust port. The conduit has a transition from a first cross-section to a second cross section at a point downstream of the exhaust port wherein the second cross section is reduced in relation to the first cross section. Gas is injected via a gas injector into the conduit in a region of the transition to create a low pressure region that removes unwanted material from the chamber.

Подробнее
Номер записи: 33
13-03-2014 дата публикации

Spinning Cell Device for Fast Standardization in Laser Ablation Inductively Coupled Plasma Spectrometry

Номер: US20140070085A1
Автор: Bier Naomi, Claverie Fanny, Malherbe Julien, Molloy John L
Принадлежит: THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY

A spinning cell device is described for fast and convenient standardization and analysis of constituents and isotopes in solid samples by laser ablation inductively coupled plasma (LA-ICP) spectrometry. The method and apparatus for performing he method require the sample under test and a standard to be spun during ablation allowing the quasi-simultaneous ablation of both materials. The aerosols resulting from the ablation of sample and standard are mixed in the ablation cell allowing quantification of the ablated metals by the method of standard addition or isotope dilution. The relative proportion of standard verses sample ablated can be changed by altering the trajectory of the laser beam. The ablated aerosol is swept into an inductively coupled plasma by a carrier gas and analyzed by mass spectrometry. 1. A dual matrix LA-ICP spectroscopic analysis system specifically adapted for performing a method of dual matrix LA-ICP analysis comprised of:at least one ablation chamber housing which substantially encloses an ablation chamber;an inductively coupled plasma ionization chamber fluidly connected to said ablation chamber;wherein said ablation chamber housing is adapted for passage of a laser beam though the inner and outer surfaces of said ablation chamber housing;wherein said ablation chamber housing includes at least two apertures to enable the entry and exit of an inert carrier gas into said inductively coupled plasma ionization chamber fluidly connected with said ablation chamber housing;a revolvable sample receptacle adapted to secure a quantity of ablative material, wherein revolvable sample receptacle includes a designated area for a quantity of a sample under test and a designated area for a standard sample;a motor operatively coupled to said revolvable sample receptacle and able to cause said sample recepticle to spin around an axis to produce a spinning sample under test; and whereina laser component which produces a laser beam, wherein said laser beam is ...

Подробнее
Номер записи: 34
13-03-2014 дата публикации

IONIZATION DEVICE, MASS SPECTROMETER INCLUDING THE IONIZATION DEVICE, AND IMAGE GENERATION SYSTEM INCLUDING THE IONIZATION DEVICE

Номер: US20140070088A1
Автор: Otsuka Yoichi
Принадлежит:

An ionization device includes a support configured to support a sample, a probe configured to determine a portion of the sample to be ionized, an irradiation unit configured to emit laser light and is disposed to irradiate with the laser light a liquid bridge portion between the sample and the probe, an extract electrode configured to extract ions obtained by ionizing the sample, a liquid supply unit configured to supply a liquid to a region of the sample, and voltage application units configured to generate an electric field between a portion of the probe that is in contact with the liquid bridge portion and the extract electrode. 1. An ionization device , comprising:a support configured to support a sample;a probe configured to determine a portion of the sample to be ionized;an irradiation unit configured to emit laser light, the irradiation unit being disposed to irradiate with the laser light a liquid bridge portion between the sample and the probe;an extract electrode configured to extract ions obtained by ionizing the sample;a liquid supply unit configured to supply a liquid to a region of the sample; andan electric field generation unit configured to generate an electric field between a portion of the probe that is in contact with the liquid bridge portion and the extract electrode.2. The ionization device according to claim 1 , further comprising:a vibration unit configured to cyclically change a relative distance between the probe and the sample,wherein while the liquid bridge portion is not formed as the probe and the sample are spaced apart from each other, the liquid on one of the probe and the sample is not irradiated with the laser light, andwherein while the liquid bridge portion is formed as the probe and the sample are close to each other, the liquid bridge portion is irradiated with the laser light.3. The ionization device according to claim 1 , further comprising:a drive unit configured to drive the laser light irradiation unit to emit pulsed ...

Подробнее
Номер записи: 35
13-03-2014 дата публикации

Ionization device, mass spectrometer including the ionization device, and image generation system

Номер: US20140072476A1
Автор: Yoichi Otsuka
Принадлежит: Canon Inc

A sample and a reagent are disposed separately. The reagent is taken into a liquid at a leading end of a needle, and a voltage is applied thereto to turn the liquid into fine liquid droplets. The sample is irradiated with laser light to cause the sample to be emitted into a space in the form of fine particles. The fine liquid droplets and the fine particles are brought into contact in the space to obtain ionized fine particles.

Подробнее
Номер записи: 36
27-03-2014 дата публикации

Matrix Assisted Laser Desorption Ionisation Mass Spectrometry Imaging (MALDI-MSI)

Номер: US20140084151A1
Автор: Ferguson Leesa Susanne, Francese Simona, Wolstenholme Rosalind
Принадлежит: SHEFFIELD HALLAM UNIVERSITY

A method of preparing a sample for matrix assisted laser desorption ionisation mass spectrometry imaging analysis by a two-step process. Firstly, a MALDI matrix is dusted on to the sample followed by a spray of a suitable solvent onto the dusted sample. The present method has been successfully applied to the detection and mapping of several analyte classes in latent fingermarks. Using the present two-step method, fingermark enhancement, recovery and analysis from different substrate surfaces is now possible enabling visual and chemical information to be obtained simultaneously via remote testing. 1. A method of preparing a matrix assisted laser desorption ionisation mass spectrometry imaging (MALDI-MSI) sample comprising:dusting a sample with a MALDI-MSI matrix powder;removing excess matrix powder from the sample;spraying the dusted sample with a solvent in which both the matrix powder and the sample are soluble.2. The method as claimed in wherein the sample is a fingermark.3. The method as claimed in further comprising lifting the sample from a surface upon which the sample is deposited using an adhesive backed strip claim 2 , pad or tape.4. The method as claimed in wherein the strip claim 3 , pad or tape is crime scene investigation (CSI) tape.5. The method as claimed in wherein the step of spraying the dusted sample comprises spraying the sample adhered to the strip claim 4 , pad or tape with the solvent.6. The method as claimed in further comprising introducing the lifted sample on the strip claim 5 , pad or tape into a MALDI mass spectrometer with imaging capabilities.7. The method as claimed in further comprising obtaining at least one image of the sample by MALDI-MSI.8. The method as claimed in wherein a particle size of the matrix powder is in the range 5 μm to 120 μm.9. The method as claimed in wherein a particle size of the matrix powder is in the range 10 μm to 30 μm.10. The method as claimed in wherein the matrix is an absorber of UV radiation and/or ...

Подробнее
Номер записи: 37
01-01-2015 дата публикации

MALDI MASS SPECTROMETRY OF PEPTIDES

Номер: US20150001386A1
Автор: Hioki Yusaku, KUYAMA Hiroki
Принадлежит:

The present invention provides a mass spectrometry method capable of detecting a smaller amount of peptide. A method for analyzing a peptide by matrix-assisted laser desorption/ionization mass spectrometry, comprising the steps of: dropping, onto a target plate, a peptide solution using, as a solvent, an aqueous solution containing 15 to 50 vol % of acetonitrile, and a matrix solution that uses, as a solvent, an aqueous solution containing 15 to 50 vol % of acetonitrile and that contains 0.05 to 1 mg/mL α-cyano-4-hydroxycinnamic acid, respectively, to prepare a droplet of peptide-matrix mixed solution; removing the solvent from the droplet of peptide-matrix mixed solution to prepare a sample for mass spectrometry as a residue; and irradiating the sample for mass spectrometry with laser to detect the peptide.

Подробнее
Номер записи: 38
01-01-2015 дата публикации

DUAL POLARITY SPARK ION SOURCE

Номер: US20150001387A1
Автор: Boumsellek Said, Ivashin Dmitriy V.
Принадлежит:

Devices and techniques for ion analysis, including ion mobility separation and mass spectrometry, are provided using a dual polarity spark ion source and having the flexibility required to optimize the detection performance for a broad range of illicit substances with different physical and chemical properties. In various embodiments, the volatility and electro-chemical aspects may be addressed by the system described herein by performing real-time detection of compounds detectable in both positive and negative polarities and/or prioritizing spectra acquisition in a given polarity due to the high volatility and therefore short residence of certain target compounds. 1. An ion analysis device , comprising:an ion source, the ion source including a spark ion source; anda controller that controls a switching frequency of voltage changes of electrodes of the ion source in order to push positive and negative ions generated by spark discharge from the ion source.2. The device according to claim 1 , further comprising:an ion mobility device into which the ions are injected from the ion source.3. The device according to claim 2 , wherein the ion mobility device includes at least one of: an ion mobility spectrometry (IMS) device claim 2 , a drift cell or a differential mobility spectrometry (DMS) device.4. The device according to claim 1 , further comprising:a vacuum interface into which the ions are received from the ion source; andan analysis component that receives the ions from the vacuum interface.5. The device according to claim 1 , wherein the controller includes a high voltage switching circuit.6. The device according to claim 1 , wherein the ion source has a point-to-point electrode configuration or a point-to-plane electrode configuration.7. The device according to claim 1 , wherein the controller controls the switching frequency of the ion source according to real time or non-real time analysis.8. The device according to claim 1 , wherein the controller controls the ...

Подробнее
Номер записи: 39
01-01-2015 дата публикации

Electrostatic Spray Ionization Method

Номер: US20150001389A1
Автор: Girault Hubert Hugues, Liu Baohong, Lu Yu, Qiao Liang, Sartor Romain, Tobolkina Elena
Принадлежит:

In an electrostatic spray ionization method for spraying a liquid layer from an insulating plate the plate is arranged between two electrodes A constant high voltage power supply is provided and an electric circuit is used to charge and discharge locally a surface of the liquid layer on the insulating plate by applying the power supply between the electrodes 1. An electrostatic spray ionization method for spraying a liquid layer from an insulating plate , the method comprising arranging the plate between two electrodes , one of the electrodes being placed behind the insulating plate , and the other electrode—the counter-electrode—being placed opposite the liquid layer and separated from it by a gas or air , providing a constant high voltage power supply and using an electric circuit to charge locally a surface of the liquid layer on the insulating plate by applying said power supply between the electrodes and to discharge the surface.2. An electrostatic spray ionization method according to wherein the insulating plate is partially covered by the liquid layer to be sprayed claim 1 , and wherein the other electrode is a counter-electrode provided by a mass spectrometer.3. An electrostatic spray ionization method according to wherein the insulating plate has been patterned to hold the liquid layer as droplets or an array of droplets.4. An electrostatic spray ionization method according to wherein a microwell or an array of microwells have been micromachined in the insulating plate to hold droplets or an array of droplets.5. An electrostatic spray ionization method according to wherein the insulating plate has been microperforated to hold droplets or an array of droplets and the electrode is covered by an insulating layer.6. An electrostatic spray ionization method according to wherein the insulating plate has been partially covered by a porous matrix able to hold the liquid layer.7. An electrostatic spray ionization method according to claim 1 , wherein said one ...

Подробнее
Номер записи: 40
07-01-2016 дата публикации

Photo or chemolabile conjugates for molecules detection

Номер: US20160003836A1
Автор: Jean-Philippe Ebran, Jonathan Stauber, Oleg Melnyk
Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, IMABIOTECH, Universite De Lille 1 Sciences Et Technologies

The present invention relates to the field of the detection of molecules of interest in a sample, preferably by mass spectrometry. The present invention concerns a label compound, a molecule labeled with said compound (a conjugate), a method of detection of a molecule of interest (a target molecule) in a sample involving said conjugate, a kit to implement said method and a process for the preparation of the label.

Подробнее
Номер записи: 41
07-01-2016 дата публикации

PARALLEL ELEMENTAL AND MOLECULAR MASS SPECTROMETRY ANALYSIS WITH LASER ABLATION SAMPLING

Номер: US20160005578A1
Автор: KARST UWE, KOEPPEN CHRISTINA, REIFSCHNEIDER OLGA, Sperling Michael, WEHE CHRISTOPH ALEXANDER
Принадлежит:

An apparatus for mass spectrometry includes a laser ablation sampler comprising a laser ablation chamber and a laser which produces a laser beam. The laser irradiates and ablates a material from a sample placed within the laser ablation chamber so as to generate an ablated sample material. A transfer tube system comprising transfer tubes connect the laser ablation sample with, and provides a parallel and simultaneous transport of the ablated sample material to, each of a soft and a hard ionization source. The soft and hard ionization sources interact with the ablated sample material to respectively generate ion populations having a mass-to-charge ratio distribution. These respective mass-to-charge ratio distributions are respectively transmitted to a molecular mass spectrometer and to an elemental mass spectrometer which provide information on the mass-to-charge ratio distribution. The mass-to-charge ratio distributions are used to characterize a composition of the ablated sample material. 123-. (canceled)24. An apparatus for mass spectrometry , the apparatus comprising:a laser ablation sampler comprising a laser ablation chamber and a laser configured to produce a laser beam, the laser ablation chamber being configured so that the laser can irradiate and ablate a material from a sample placed within the laser ablation chamber so as to generate an ablated sample material;a soft ionization source;a molecular mass spectrometer comprising a molecular mass spectrometer entrance, the molecular mass spectrometer being operatively connected with the soft ionization source;a hard ionization source;an elemental mass spectrometer comprising an elemental mass spectrometer entrance, the elemental mass spectrometer being operatively connected with the hard ionization source;a transfer tube system comprising connecting tubes configured to connect the laser ablation sampler with, and to provide a parallel and simultaneous transport of the ablated sample material to, each of the ...

Подробнее
Номер записи: 42
13-01-2022 дата публикации

PULSATILE FLOW ATMOSPHERIC REAL TIME IONIZATION

Номер: US20220013347A1
Автор: MUSSELMAN BRIAN D, Oro Scott
Принадлежит: IONSENSE INC.

In an embodiment of the present ambient ionization experiment, the abundance of background chemicals relative to ions of interest is decreased by pulsing the carrier gas used to generate the excited species directed at the sample. The excited species are stepwise directed at the sample reducing the overall abundance of background chemicals introduced into the ionizing region. In an embodiment of the present ambient ionization experiment, the combination of stepping the sample in front of the excited species and pulsing the carrier gas used to generate the excited species increases the sensitivity of detection. 115-. (canceled)16. An ionizer for pulsed atmospheric ionization of a sample comprising:a first atmospheric pressure chamber comprising:an inlet for a carrier gas;a first electrode;a counter-electrode; andan outlet port;a power supply configured to energize the first electrode and the counter-electrode to provide a current between the first and counter-electrodes to generate a discharge; anda pulse generator configured to pulse the carrier gas into the first atmospheric pressure chamber to generate two or more pulses of carrier gas forming ions of the sample.17. The ionizer of claim 16 , where two or more pulses of carrier gas are each for a duration of time t.18. The ionizer of claim 17 , where the two or more pulses of carrier gas are separated by a time t.19. The ionizer of claim 17 , where interaction of the two or more pulses of carrier gas with the discharge during tgenerates one or more ionizing species.20. The ionizer of claim 19 , where a gaseous contact between the one or more ionizing species and the two or more pulses of carrier gas directs the one or more ionizing species formed at atmosphere through the outlet port at the sample.21. The ionizer of claim 20 , where the one or more ionizing species comprise ions claim 20 , electrons claim 20 , hot atoms claim 20 , hot molecules claim 20 , radicals and metastable neutral excited state species.22. ...

Подробнее
Номер записи: 43
07-01-2021 дата публикации

APPARATUS AND METHOD FOR ENHANCING SIGNAL INTENSITY OF RADIO FREQUENCY GLOW DISCHARGE MASS SPECTROMETRY

Номер: US20210005442A1
Автор: QIAN Rong, Zhou Lei, ZHU Yueqin, ZHUO Shangjun
Принадлежит:

Regarding the problem of low signal intensity during material analysis using existing radio frequency glow discharge mass spectrometry, an apparatus and method for enhancing signal intensity of radio frequency glow discharge mass spectrometry are provided, so as to enhance the signal intensity during inorganic material analysis using a radio frequency glow discharge mass spectrometer. The apparatus comprises a sample introduction cell having a sample introduction rod and having a sample fixed thereon, and an array magnet enhancement portion having a housing shell and magnets arranged in an array. The array magnet enhancement portion is fixed between the sample introduction rod in the sample introduction cell and the sample and is tightly attached to the sample. 1. An apparatus for enhancing signal intensity of radio frequency glow discharge mass spectrometry , comprising:a sample introduction cell having a sample introduction rod and having a sample fixed thereon; andan array magnets enhancement portion having a housing shell and magnets arranged in array, whereinthe array magnets enhancement portion is fixed between the sample introduction rod and the sample in the sample introduction cell, and is tightly attached to the sample.2. The apparatus for enhancing signal intensity of radio frequency glow discharge mass spectrometry according to claim 1 , whereinthe magnets arranged in an array are placed in the housing shell, and direction of magnetic induction of each magnet is parallel to the sample.3. A method for enhancing signal intensity of radio frequency glow discharge mass spectrometry claim 1 , using an apparatus comprises a sample introduction cell having a sample introduction rod and having a sample fixed thereon claim 1 , and an array magnets enhancement portion having a housing shell and magnets arranged in an array claim 1 , the method comprising the following steps:installing and fixing the array magnets enhancement portion between the sample introduction ...

Подробнее
Номер записи: 44
03-01-2019 дата публикации

IONIZATION MASS SPECTROMETRY METHOD AND MASS SPECTROMETRY DEVICE USING SAME

Номер: US20190006163A1
Автор: HEO Sung Woo, LEE Hyoung Jun, OH Ji-Seon, YIM Yong-Hyeon
Принадлежит:

A mass spectrometry device includes a sample seating part including an ultrasonic vibrator having a through hole through which liquid particles formed by the ultrasonic vibrator from an adsorbent material including a sample and a solvent are discharged, the adsorbent material being seated on the ultrasonic vibrator; a reaction part in which plasma or an ionization medium generated by plasma come into contact with the liquid particles discharged from the through hole to form an ionized material; an introduction part discharging and introducing the ionized material to a detection part; and the detection part analyzing the ionized material discharged from the introduction part. The mass spectrometry device and the mass spectrometry method can detect the components of various samples by converting a sample into liquid particles using ultrasonic waves and applying plasma and can detect samples in various fields without regard to locations. 1. A mass spectrometry device comprising:a sample seating part including an ultrasonic vibrator having a through hole through which liquid particles formed by the ultrasonic vibrator from an adsorbent material including a sample and a solvent are discharged, the adsorbent material being seated on the ultrasonic vibrator;a reaction part in which plasma or an ionization medium generated by plasma come into contact with the liquid particles discharged from the through hole to form an ionized material;an introduction part discharging and introducing the ionized material to a detection part; andthe detection part analyzing the ionized material discharged from the introduction part.2. The mass spectrometry device of claim 1 , whereinthe liquid particles are formed from the adsorbent material by vibration of the ultrasonic vibrator and introduced to the reaction part through the through hole.3. The mass spectrometry device of claim 1 , whereina diameter of the through hole is 0.1 to 2 mm.4. The mass spectrometry device of claim 1 , further ...

Подробнее
Номер записи: 45
03-01-2019 дата публикации

System for Minimizing Electrical Discharge During ESI Operation

Номер: US20190006165A1
Автор: Corr John J., Covey Thomas R., Kovarik Peter
Принадлежит: DH Technologies Development Pte. Ltd.

Methods and systems are provided for reducing the occurrence of unwanted electrical discharge when operating an electrospray ion source to generate ions for mass spectrometric analysis. In accordance with various aspects of the applicant's teachings, the methods and systems described herein can provide for controlling the ion emission current so as to limit the onset of avalanche of electrical discharge between the electrospray electrode and the counter electrode under ionization conditions that typically tend to increase the likelihood of such discharge (arcing), while nonetheless providing for maximal ionization efficiency. In various aspects, emission currents between the electrospray electrode and the counter electrode through which the ions are transmitted to a downstream mass analyzer can be maintained at elevated levels, below 10 μA, for example, without the electric potential between the electrospray electrode and the counter electrode initiating the electrical discharge avalanche that results from the dielectric break-down of the air gap therebetween, which can cause sputtering and effect the long-term operation of the ESI source. 1. An electrospray ion source assembly for generating ions for analysis by a mass spectrometer , comprising:an ion source housing defining an ionization chamber, the ionization chamber configured to be disposed in fluid communication with a sampling orifice of a mass spectrometer system, the sampling orifice formed in a counter electrode;at least one heater for heating the ionization chamber;an electrospray electrode defining an axial bore therethrough for transmitting a liquid sample received from a sample source at an inlet end of the electrospray electrode to an outlet end for discharging the liquid sample from the electrospray electrode into the ionization chamber;a power source configured to provide an electrical voltage to an electrical circuit containing the electrospray electrode and the counter electrode so as to generate ...

Подробнее
Номер записи: 46
03-01-2019 дата публикации

APPARATUS AND METHOD FOR GENERATING CHEMICAL SIGNATURES USING DIFFERENTIAL DESORPTION

Номер: US20190006166A1
Автор: Musselman Brian D.
Принадлежит: IONSENSE INC.

The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes. 1. A method of analyzing a sample , the method comprising the steps:contacting a sorbent coated screen with a sample, where the sorbent coated screen is of sufficient size to permit multiple exposure of the sorbent coated screen to a plurality of different temperature gasses from a desorption ionization source;directing a carrier gas with a first temperature from the desorption ionization source at a first target area on the sorbent coated screen to generate a plurality of first sample ions;directing the carrier gas with a second temperature from the desorption ionization source at a second target area on the sorbent coated screen to generate a plurality of second sample ions;directing one or both the plurality of first sample ions and the plurality of second sample ions into an analysis instrument; andanalyzing one or both the plurality of first sample ions and the plurality of second sample ions, thereby analyzing the sample.2. The method of claim 1 , where the sorbent coated screen comprises one or more materials selected from the group consisting of wire mesh screen claim 1 , paper screen claim 1 , plastic screen claim 1 , fiber screen claim 1 , cloth screen claim 1 , polymer screen claim 1 , silica screen claim 1 , Teflon screen claim 1 , polymer impregnated Teflon screen claim 1 , cellulose screen claim 1 , and hydrophobic support material coated and impregnated mesh screen.3. The method of claim 1 , where the sorbent coated screen comprises a sorbent coating of one or more materials selected from the group consisting of C-18 claim 1 ...

Подробнее
Номер записи: 47
03-01-2019 дата публикации

TIME-OF-FLIGHT MASS SPECTROMETER

Номер: US20190006168A1
Автор: Mizutani Shiro
Принадлежит: SHIMADZU CORPORATION

An acceleration voltage generator () generates a high-voltage pulse to be applied to a push-out electrode (), by operating a switch section () to turn on and off a high direct-current voltage generated by a high-voltage power supply (). A drive pulse signal is supplied from a controller () to the switch section () through a primary-side drive section (), transformer (), and secondary-side drive section (). The measurement period of a repeated measurement is changed according to a target m/z range. A primary-voltage controller () controls a primary-side power supply () to change a primary-side voltage according to the measurement period, thereby adjusting the voltage to be applied between the two ends of a primary winding of the transformer () by the primary-side drive section (). The pulse signal fed to the switch section () overshoots due to LC resonance. Due to this overshoot, the voltage at the point in time where the pulse signal begins to rise varies depending on the measurement period. Such a variation of the voltage at the point in time where the pulse signal begins to rise causes a discrepancy in the timing at which the rising slope crosses the threshold voltage of MOSFET. However, this discrepancy can be corrected by adjusting the primary-side voltage. As a result, high mass accuracy can be achieved irrespective of the measurement period. 1. A time-of-flight mass spectrometer which repeats a measurement covering a predetermined time-of-flight range with a predetermined period , the time-of-flight mass spectrometer comprising:a) an ion ejector for ejecting ions to be analyzed into a flight space by imparting acceleration energy to the ions by an effect of an electric field created by a voltage applied to an electrode;b) a high-voltage pulse generator for applying, to the electrode of the ion ejector, a high-voltage pulse for ejecting ions, the high-voltage pulse generator including: a direct-current power supply for generating a high direct-current voltage; ...

Подробнее
Номер записи: 48
08-01-2015 дата публикации

Pulsed Mass Calibration in Time-of-Flight Mass Spectrometry

Номер: US20150008310A1
Автор: Christian Tanner, Edward B. Ledford, Jr., Marc Gonin, Martin Tanner
Принадлежит: Zoex Corp

A method is provided for calibrating mass-to-charge ratio measurements obtained from a time-of-flight mass spectrometer used as a detector for a chromatographic system. The method can include introducing a calibrant material into the time-of-flight mass spectrometer after a sample is introduced to the chromatographic system, but before the analysis of the sample is complete, such that calibrant material and sample material are not present at the ion source of the mass spectrometer, contemporaneously, and back-flushing residual or leaking calibrant through a back-flush line and away from the mass spectrometer.

Подробнее
Номер записи: 49
08-01-2015 дата публикации

GENERATION OF REAGENT IONS FOR ION-ION REACTIONS

Номер: US20150008312A1
Автор: Campbell John Lawrence, LEBLANC Yves
Принадлежит:

An apparatus, system and method of providing that allow for the generation of reagent ions within an inner region of a mass spectrometer for use in ion-ion reactions such as PTRs and ETD using a reagent ion generator. The location where these reagent ions are generated can be as close as possible to the point of action, or the reaction zone where the reagent ion and analyte ions will interact via ion-ion reactions to cause, e.g., PTRs and/or ETD. 1. A mass spectrometer system , comprising:a first chamber, a hollow conduit extending from a proximal end to a distal end, wherein said proximal end is adapted for introducing reagent molecules from a source into said conduit and said distal end is disposed inside said first chamber, and', 'an electrically conducting wire disposed at least partially within said hollow conduit and extending from a proximal portion to a distal tip portion, wherein said distal tip portion is positioned in proximity to said distal end of the conduit, and', 'a voltage source adapted for electrically coupling to a portion of the wire for applying a voltage to said wire sufficient for causing an electric discharge in proximity of said distal tip portion of the wire., 'a reagent ion generator coupled to said first chamber, said ion generator comprising2. The mass spectrometer system of claim 1 , wherein said voltage source is adapted to apply a voltage between about −5000 and about +5000 volts to the conducting wire.3. The mass spectrometer system of claim 1 , wherein said wire is covered by an electrically insulating material over a length portion thereof other than said distal tip portion.4. The mass spectrometer system of claim 1 , wherein said reagent molecules comprise any of a perfluorocarbon or an aromatic molecule.5. The mass spectrometer system of claim 1 , wherein said reagent molecules form positive ions when exposed to a discharge and/or corona from the exposed tip of the conducting wire.6. The mass spectrometer system of claim 1 , ...

Подробнее
Номер записи: 50
08-01-2015 дата публикации

IONIZATION WITH FEMTOSECOND LASERS AT ELEVATED PRESSURE

Номер: US20150008313A1
Автор: Corkum Paul, Loboda Alexandre V., Rayner David
Принадлежит:

The present disclosure generally provides ionization methods and devices for use in mass spectrometry. In some embodiments, the ionization methods and devices employ short laser pulses (e.g., pulses having pulsewidths in a range of about 2 fs to about 1 ps) at a high intensity (e.g., an intensity in a range of about 1 TW/cmto about 1000 TW/cm) to ionize an analyte an ambient pressure greater than about 10Torr (e.g., an ambient pressure in a range of about 1 atmosphere to about 100 atmospheres). 1. In a mass spectrometer , a method for ionizing a sample , comprising:{'sup': −5', '5', '2', '2, 'irradiating a sample at an ambient pressure in a range of about 10Torr to about 10Torr with one or more radiation pulses having a pulsewidth in a range of about 2 fs to about 1 ps at a pulse power density in a range of about 1 TW/cmto about 1000 TW/cmto cause ionization of at least a portion of the sample.'}2. The method of claim 1 , wherein said radiation pulses have a pulsewidth in a range of about 30 fs to about 500 fs.3. The method of claim 1 , wherein said radiation pulses have a pulsewidth in a range of about 50 fs to about 100 fs.4. The method of claim 1 , further comprising introducing the sample into an ionization chamber and focusing said radiation pulses onto a focal volume in said chamber to cause said ionization of the sample.5. The method of claim 1 , wherein said radiation pulses cause non-resonant ionization of one or more constituents of said sample.6. The method of claim 1 , wherein said radiation pulses have a central wavelength in a range of about 200 nm to about 100 microns.7. The method of claim 1 , wherein said radiation pulses have a central wavelength in a range of about 600 nm to about 10 microns.8. The method of claim 1 , wherein said radiation pulses have a central wavelength in a range of about 800 nm to about 3 microns.9. The method of claim 1 , wherein said radiation pulses are applied to the sample at a repetition rate in a range of about 1 Hz to ...

Подробнее
Номер записи: 51
08-01-2015 дата публикации

DYNAMIC MULTIPOLE KINGDON ION TRAP

Номер: US20150008316A1
Автор: Guna Mircea
Принадлежит: DH Technologies Development Pte. Ltd.

An ion trap is disclosed comprising a plurality of elongate electrodes aligned with one another and with a central longitudinal axis along respective longitudinal axes and that are spaced apart from one another and disposed about a central longitudinal axis to form a quadrupole. The ion trap further comprises an elongate electrode that is aligned with and disposed along the central longitudinal axis, and circuitry coupled to the outer electrodes is suitable for driving the central and outer electrodes to selectively trap of ions within a region defined between the central electrode and the outer. 1. An ion trap , comprising:a. a plurality of elongate electrodes (“outer electrodes”), each having a longitudinal axis that is aligned with a central longitudinal axis, the plurality of elongate electrodes being spaced apart from one another and disposed about that central longitudinal axis to form a quadrupole;b. an elongate electrode (“central electrode”) that is aligned with and disposed along the central longitudinal axis; andc. circuitry coupled to the outer electrodes suitable for driving the central electrode and the plurality of outer electrodes so as to selectively trap ions within a region defined between the central electrode and the outer electrodes.2. The ion trap of claim 1 , wherein the circuitry can selectively trap such ions by applying(i) to the outer electrodes at least one of a DC potential and an RF-varying potential such that each pair of outer electrodes disposed opposite one another vis-a-vis the central longitudinal axis is at an RF-varying potential to each other pair of outer electrodes disposed opposite one another vis-a-vis that axis, and/or(ii) to the central electrode at least one of a DC voltage and an RF-varying voltage.3. The ion trap of claim 2 , comprising at least one of an ion inlet and an ion outlet.4. The ion trap of claim 3 , wherein at least one of the ion inlet and the ion outlet are grid lenses.5. The ion trap of claim 4 , ...

Подробнее
Номер записи: 52
08-01-2015 дата публикации

METHOD AND APPARATUS FOR IMPROVED SENSITIIVITY IN A MASS SPECTROMETER

Номер: US20150008320A1
Автор: Loboda Alexandre V.
Принадлежит:

An ion source and an ion guide chamber are provided. The ion guide chamber having a gas flow, the gas flow having a longitudinal velocity and a transverse velocity. The ion guide chamber having an exit aperture and at least one ion guide. The at least one ion guide having an entrance end and an exit end with an exit cross-section wherein the exit cross-section is sized to be smaller in area than the entrance cross-section. The at least one ion guide having a plurality of elongated electrodes wherein a gap between the elongated electrodes and the shape of the elongated electrodes in the vicinity of the gap are essentially the same along the length of the at least one ion guide for confining the ions in the vicinity of the gap by a combination of the transverse velocity of the gas and the RF voltage. 1. A mass spectrometer comprising:an ion source for generating a beam of ions;an ion guide chamber for receiving the ions from the ion source, the ion source chamber having a gas flow wherein the ions are entrained in the gas flow, the gas flow having a longitudinal velocity and a transverse velocity; the ion guide chamber further comprising an exit aperture for passing the ions from the ion guide chamber;at least one ion guide located in the ion guide chamber, the at least one ion guide having an entrance end and a predetermined entrance cross-section defining an internal volume;the at least one ion guide having an exit end and an exit cross-section wherein the exit cross-section is sized to be smaller in area than the entrance cross-section;a power supply for providing an RF voltage to the at least one ion guide; andthe at least one ion guide comprising at least one multipole ion guide having a plurality of elongated electrodes wherein a gap between the elongated electrodes and the shape of the elongated electrodes in the vicinity of the gap are essentially the same along the length of the at least one ion guide for confining the ions in the vicinity of the gap by a ...

Подробнее
Номер записи: 53
14-01-2016 дата публикации

Mass spectrometry method using matrix

Номер: US20160011205A1
Автор: Shunsuke Izumi, Yuko Fukuyama
Принадлежит: Shimadzu Corp

The present invention provides amass spectrometry method using a matrix that is capable of easily and efficiently improving ionization efficiency in mass spectrometry without modifying a molecule to be analyzed, and a matrix for mass spectrometry. A mass spectrometry method using, as a matrix, a 2,4,6-trihydroxyalkylphenone represented by the following general formula (I): where R is an alkyl group having 4 to 12 carbon atoms. The mass spectrometry method as described above, wherein an analysis object is a hydrophobic compound, particularly, a hydrophobic peptide.

Подробнее
Номер записи: 54
10-01-2019 дата публикации

LIQUID SAMPLE INTRODUCTION SYSTEM FOR ION SOURCE AND ANALYSIS SYSTEM

Номер: US20190011406A1
Автор: MAEDA Kazuma
Принадлежит: SHIMADZU CORPORATION

A liquid sample introduction system for an ion source which ionizes a liquid sample by supplying the liquid sample to an ionization probe in an ion source and blowing an atomization-promoting gas at the liquid sample exiting from the tip of the ionization probe, the system including: a hermetically closable liquid sample container for holding a liquid sample; a liquid-supply-gas passage having one end connected to a point in a passage for an atomization-promoting gas leading to the ion source, and the other end connected to a space above a liquid level in the liquid sample container; a sample supply passage having one end connected to a space below the liquid level in the liquid sample container and the other end connected to the ionization probe; and a passage-switching unit in the sample supply passage for switching the sample supply passage between the communicating state and the closed state. 2. The liquid sample introduction system for an ion source according to claim 1 , further comprising a liquid-supply-gas pressure regulator for regulating a pressure of the gas flowing through the liquid-supply-gas passage.3. (canceled)4. The liquid sample introduction system for an ion source according to claim 1 , wherein one of the plurality of sub-ports is connected to an exit port of a liquid chromatograph.5. An analyzing system claim 1 , comprising:an ion analyzer for ionizing a target liquid sample after ionizing the liquid sample in an ionization chamber;{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the liquid sample introduction system for an ion source according to for ionizing a reference liquid sample in the ionization chamber; and'}a control unit for operating the liquid sample introduction system for an ion source so as to supply the reference liquid sample to the ionization probe during an execution of an analysis of an ion generated from the target liquid sample.6. The analyzing system according to claim 5 , wherein the control unit operates the liquid ...

Подробнее
Номер записи: 55
12-01-2017 дата публикации

MASS SPECTROMETER

Номер: US20170011897A1
Автор: YAMAGUCHI Shinichi
Принадлежит: SHIMADZU CORPORATION

The mass spectrometer () provides an ionization chamber () therein with: a probe () having a sample to be measured flow path () for spraying a sample to be measured; and a standard sample flow path () for spraying a standard sample used for the calibration of the mass-to-charge ratio of the mass spectrum into the ionization chamber. The standard sample is intermittently introduced into the ionization chamber via a pulse valve (). Thus, mixing of the sample to be measured and the standard sample can be prevented, while the timing according to which the standard sample is introduced can be appropriately controlled. It also becomes possible to acquire an accurate mass spectrum for each sample to be measured even in the case where a number of types of samples to be measured are introduced into the ionization chamber one after another over a short period of time. 1. A mass spectrometer , comprising an ionization chamber where a sample is ionized , and a mass spectrometry unit into which ions are introduced from the ionization chamber , whereinsaid ionization chamber has a housing that provides a space inside the housing,a probe having a sample to be measured flow path in order to spray a sample to be measured into the inside of said ionization chamber is attached to said housing, and an ion introducing tube is created in said housing so that the inside of said ionization chamber and the inside of the mass spectrometry unit communicate,a mass spectrum value that is gained by measuring a sample to be measured is calibrated using a mass spectrum value that is gained by measuring a standard sample, andthe mass spectrometer is characterized by further comprising a standard sample flow path that sprays a standard sample into the inside of said ionization chamber, and a pulse valve that is arranged in the standard sample flow path so as to introduce a standard sample intermittently.2. The mass spectrometer according to claim 1 , characterized in that said standard sample flow ...

Подробнее
Номер записи: 56
11-01-2018 дата публикации

Method of Charge Reduction of Electron Transfer Dissociation Product Ions

Номер: US20180012743A1
Автор: Brown Jeffery Mark, Chakraborty Asish B., Chen Weibin, Gebler John Charles
Принадлежит:

A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine. 1. A mass spectrometer comprising:a cell arranged and adapted to fragment ions and generate first ions, wherein said first ions comprise product or fragment ions resulting from the fragmentation of parent or analyte ions, and said product or fragment ions comprise a majority of b-type product or fragment ions and/or y-type product or fragment ions; anda first device arranged and adapted to react said first ions with one or more reagent gases or vapours in order to reduce the charge state of said first ions, wherein said first device comprises a first ion guide comprising a plurality of electrodes.2. A mass spectrometer as claimed in claim 1 , wherein said one or more reagent gases or vapours comprises one or more neutral claim 1 , non-ionic or uncharged reagent gases or vapours.3. A mass spectrometer as claimed in claim 1 , wherein said first ions comprise product or fragment ions resulting from the fragmentation of parent or analyte ions by Collision Induced Dissociation.4. A mass spectrometer as claimed in claim 1 , wherein said first ions comprise product or fragment ions resulting from the fragmentation of parent or analyte ions by Surface Induced Dissociation.5. A mass spectrometer as claimed in claim 1 , wherein said first device comprises a Proton Transfer Reaction device.6. A mass spectrometer as claimed in claim 1 , wherein claim 1 , in use claim 1 , protons are transferred from at least some of said first ions to said one or more reagent gases or vapours.7. A mass spectrometer as claimed in claim 1 , wherein claim 1 , in use claim 1 , protons are transferred from at least some of said first ions which comprise one or more multiply charged analyte ...

Подробнее
Номер записи: 57
11-01-2018 дата публикации

MASS SPECTROMETRY USING LASERSPRAY IONIZATION

Номер: US20180012745A1
Автор: Trimpin Sarah
Принадлежит:

Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 Daltons. The analysis can be solvent-based or solvent-free. Solvent-free analysis following LSI allows for improved spatial resolution beneficial in surface and/or tissue imaging. 1. A method for producing multiply-charged ions for analysis of a material comprising , a. applying the material and a matrix to a surface as a material/matrix analyte;b. ablating the material/matrix analyte at or near atmospheric pressure with a laser; andc. passing the laser-ablated material/matrix analyte through a heated region before the material/matrix analyte enters the high vacuum area of a mass spectrometer.2. The method of claim 1 , wherein the matrix is composed of small molecules that absorb energy at the laser's wavelength.3. The method of claim 2 , wherein the small molecules are selected from the group consisting of a dihydroxybenzoic acid claim 2 , 2 claim 2 ,5-dihydroxybenzoic acid (2 claim 2 ,5-DHB); a dihydroxyacetophenones claim 2 , 2 claim 2 ,5-dihydroxyacetophenone (2 claim 2 ,5-DHAP) claim 2 , 2 claim 2 ,6-dihydroxyacetophenone (2 claim 2 ,6-DHAP) claim 2 , 2 claim 2 ,4 claim 2 ,6-trihydroxy acetophenone (2 claim 2 ,4 claim 2 ,6-THAP) claim 2 , a-cyano-4-hydroxycinnamic acid (CHCA) claim 2 , 2-aminobenzyl alcohol (2-ABA) and combinations thereof.4. The method of claim 1 , wherein the laser has an output in the ultraviolet region.5. The method of claim 1 , wherein the laser is a nitrogen laser (337 nm) or a frequency tripled Nd/YAG laser (355 nm).6. The method of claim 1 , wherein the heated region is a heated tube.7. The method of claim 6 , wherein the tube is constructed of heat-tolerant material that does not emit vapors detrimental to the mass spectrometer vacuum system.8. The method of claim 7 , wherein the ...

Подробнее
Номер записи: 58
10-01-2019 дата публикации

APPARATUS AND METHOD FOR CHEMICAL PHASE SAMPLING ANALYSIS

Номер: US20190013190A1
Автор: Musselman Brian D.
Принадлежит: IONSENSE INC.

In various embodiments of the invention, a sorbent coated mesh or grid introduced into contact with a sample can be monitored at appropriate temperatures, positions and time intervals to determine species present in the sample. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present on the sorbent coated mesh or grid which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules from the sample whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the sample. 1. A system for analyzing a sample comprising: a first tine with a first major axis adapted for insertion into a container;', 'a first sorbent material applied to a first area of the first tine; and', 'a second sorbent material applied to a second area of the first tine, where the first sorbent material is adapted to collect a first sample molecule present in the sample, where the second sorbent material is adapted to collect a second sample molecule present in the sample;, 'a sample collection device comprisinga mesh in proximity with the first tine;a power source electrically connected to the mesh adapted to deliver at least a first current to the mesh;an ionization source directing ionizing species at the first area to generate a plurality of ions of the sample; anda spectrometer adapted to analyze the plurality of ions of the sample.2. The system of claim 1 , further comprising a holder to position the first tine relative to the mesh claim 1 , where the holder is adapted to adjust at least the first area in registration with the mesh.3. The system of claim 1 , where a distance between the first area and the mesh is between:{'sup': '−5', 'a lower limit of approximately 10m; and'}{'sup': '−2', 'an upper limit of approximately 10m.'}4. The system of claim 1 , where a ...

Подробнее
Номер записи: 59
10-01-2019 дата публикации

ICP MASS SPECTROMETER

Номер: US20190013192A1
Автор: Nakano Tomohito
Принадлежит: SHIMADZU CORPORATION

Provided is an ICP mass spectrometer which is able to effectively discharge residual water by limiting the consumption of Ar gas and a fluctuation in supply pressure of an Ar gas source at the time of an Ar gas purge for a coolant system. The ICP mass spectrometer is provided with: a device body part ; a coolant system that supplies a coolant from a water source to to-be-cooled structure parts including a high-freqency power supply , a high-frequency coil , and a sample introduction part , which need to be cooled; and an Ar gas supply system . Intermediate valves V, V are disposed on the downstream side of a main valve V, a purge gas channel having a purge valve V, and a meeting point G of the purge gas channel . The to-be-cooled structure parts are connected to a cooling-use pipe on the downstream side of the intermediate valves V, V. A valve control part in configured to perform intermittent purge control of repeating accumulation and discharge of the Ar gas on the upstream side of the intermediate valves V, V by intermediately opening and closing the intermediate valves V, V where the Ar gas is being sent. 1. An ICP mass analysis device characterized in that it comprises:a device main body unit which supplies Ar gas for plasma generation and sample gas, via a gas flow rate control unit which controls gas flow rate, to a reaction tube of a plasma torch, ionizes the sample gas by applying a high frequency voltage from a high frequency power supply to a high frequency coil of said plasma torch, and draws in generated sample ions through a sample introduction unit to a mass analyzer to perform mass analysis;a cooling water system in which water cooling piping is connected as a flow passage to cooled structures which require cooling, including said high frequency power supply, said high frequency coil and said sample introduction unit, and which supplies cooling water from a water source to said cooled structures; andan Ar gas supply system in which gas piping is ...

Подробнее
Номер записи: 60
10-01-2019 дата публикации

ION EXCITATION METHOD IN LINEAR ION TRAP

Номер: US20190013194A1
Автор: CHEN Yinjuan, DANG Qiankun, DING Chuanfan, Xie Xiaodong, XU Fuxing
Принадлежит:

The present invention relates to the technical field of mass analysis instruments. Disclosed is an ion excitation method in a linear ion trap. The method comprises: in a linear ion trap, and at an ion collision-induced dissociation stage, simultaneously applying an auxiliary excitation signal in radial X and Y directions thereof; increasing the kinetic energy of ions in the two directions, thereby increasing collisions with a center gas to cause dissociation; and converting the kinetic energy to internal energy to achieve tandem mass spectrometry analysis. The kinetic energy in the X and Y directions of the ion is increased, and compared to a conventional dissociation method in which ions are primarily excited in one direction, more kinetic energy is converted to internal energy, thus improving dissociation efficiency, shortening reaction time, and addressing a low mass cutoff effect in the ion trap. 1. A method of ion excitation for dissociation in linear ion traps , comprising: Applying two dipolar or monopole AC excitation signals to x and y pairs of electrodes in linear ion traps to cause ions to undergo excitation simultaneously in the radial x and y directions2. The method of claim 1 , wherein the excitation AC signal only contain a single frequency.3. The method of claim 1 , wherein the excitation AC signal is the sum of multiple frequency components.4. The method of claim 1 , wherein the waveforms applying to the x electrodes and y electrodes can be the same type. In this case claim 1 , the frequency claim 1 , amplitude claim 1 , phase difference of the two AC signals can be the same or different. the phase difference varies from 0 to 360 degrees claim 1 , but does not include 90 degrees.5. The method of claim 1 , wherein the types of the two AC waveforms applying to the two pairs of electrodes are completely different.6. The method of claim 1 , wherein the mass spectrometer can be quadrupoles claim 1 , linear ion trap with the hyperbolic electrodes claim 1 ...

Подробнее
Номер записи: 61
14-01-2021 дата публикации

Mass Spectrometer

Номер: US20210013017A1
Автор: Jung Gerhard, Schwieters Johannes
Принадлежит:

An isotope ratio mass spectrometer has an ion source, a static field mass filter, a reaction cell to induce a mass shift reaction, and a sector field mass analyser for spatially separating ions from the reaction cell according to their m/z. A detector platform detects a plurality of different ion species separated by the sector field mass analyser. The static field mass filter has a first Wien filter that deflects ions away from a longitudinal symmetry axis of the spectrometer in accordance with the ions' m/z, and a second Wien filter that deflects ions back towards the longitudinal symmetry axis in accordance with the ions' m/z. An inverting lens is positioned along the longitudinal axis between the Wien filters to invert the direction of deflection of the ions from the first Wien filter. The static field mass filter provides high transmission and improved spectrometer sensitivity. The first and second Wien filters permit simple tuning. 1. A static field mass filter for a mass spectrometer comprising:an entrance aperture configured to receive an ion beam from an ion source;an exit aperture configured to eject ions, the static field mass filter defining a longitudinal symmetry axis between the entrance and exit apertures;a first Wien filter configured to deflect ions away from the longitudinal symmetry axis in accordance with their m/z;a second Wien filter configured to deflect the ions back towards the longitudinal symmetry axis in accordance with their m/z; andan inverting lens positioned along the longitudinal symmetry axis between the first and second Wien filters, to invert the direction of deflection of the ions from the first Wien filter.2. A mass spectrometer comprising the static field mass filter of claim 1 , an ion source arranged upstream of the static field mass filter and configured to direct ions into the entrance aperture thereof claim 1 , and a mass analyser arranged downstream of the static field mass filter claim 1 , configured to mass analyse ...

Подробнее
Номер записи: 62
09-01-2020 дата публикации

Novel differential electrochemical mass spectrometry (DEMS) cell

Номер: US20200013600A1
Автор: Bell Alexis T., Clark Ezra L.
Принадлежит: The Regents of the University of California

The present invention provides for a differential electrochemical mass spectrometry (DEMS) cell comprising a working electrode chamber configured such that an electrolyte enters the working electrode chamber through a channel running through the working electrode. 17-. (canceled)8. A differential electrochemical mass spectrometry (DEMS) cell , comprising:a body, the body defining an anolyte chamber, a catholyte chamber, and a collection chamber;an ion-conducting membrane separating the anolyte chamber and the catholyte chamber;a counter electrode disposed in the anolyte chamber;a working electrode disposed in the catholyte chamber, the working electrode being a washer-shaped electrode and channel defined in a center of the working electrode, the channel functioning as an inlet for catholyte to the catholyte chamber; anda pervaporation membrane, a first surface of the pervaporation membrane defining a portion of the collection chamber, and the collection chamber being in fluid communication with the catholyte chamber.9. The DEMS cell of claim 8 , wherein the catholyte chamber has a cylindrical shape claim 8 , wherein a plurality of down channels are defined in the body between the catholyte chamber and the collection chamber claim 8 , and wherein an inlet for catholyte for each of the plurality of down channels is defined in the cathode chamber along a diameter of the catholyte chamber.10. The DEMS cell of claim 9 , wherein the plurality of down channels defined in the body between the catholyte chamber and the collection chamber consists of four down channels claim 9 , and wherein the inlet for each of the four down channels is positioned symmetrically about the diameter of the catholyte chamber.11. The DEMS cell of claim 9 , wherein the catholyte is operable to flow into the catholyte chamber through the channel claim 9 , to flow outwards from the center of the working electrode to the inlets of the plurality of down channels claim 9 , and to flow into collection ...

Подробнее
Номер записи: 63
09-01-2020 дата публикации

LOW CROSS-TALK FAST SAMPLE DELIVERY SYSTEM BASED UPON ACOUSTIC DROPLET EJECTION

Номер: US20200013605A1
Автор: Morris Michael Raymond, Pringle Steven Derek, Richardson Keith, Sinclair Ian
Принадлежит: MICROMASS UK LIMITED

An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid. 127-. (canceled)28. An ion source for a mass spectrometer comprising:a transducer arranged and adapted to focus acoustic energy onto a surface of a sample fluid without said transducer directly contacting said sample fluid, wherein said transducer is arranged and adapted to eject one or more droplets from said sample fluid in a substantially controlled manner, and wherein said one or more droplets comprise a majority of un-ionised droplets; andan ionisation device arranged and adapted to ionise a volume of liquid comprising said one or more droplets ejected from said sample fluid by said transducer.29. An ion source as claimed in claim 28 , wherein said ionisation device is arranged and adapted to emit a stream of charged particles.30. An ion source as claimed in claim 29 , wherein said stream of charged particles emitted by said ionisation device comprise charged droplets and/or ions.31. An ion source as claimed in claim 28 , wherein said ionisation device comprises an Electrospray ion source claim 28 , an Atmospheric Pressure Chemical Ionisation (“APCI”) ion source claim 28 , an Impactor ion source wherein a sample is ionised upon impacting a target claim 28 , a Laser ion source claim 28 , an ultra-violet (“UV”) photoionisation device or an infra-red (“IR”) photoionisation device.32281. An ion source as claimed in claim claim 28 , wherein said ionisation device comprises an Electrospray ion source arranged and adapted to ionise said volume of liquid.33. An ion source as claimed in claim 28 , wherein said ionisation device is arranged and adapted to act as a source of secondary ionisation for said volume of liquid comprising said one or more droplets ejected from said sample fluid by said transducer.34. An ion source as claimed in claim 28 , wherein said transducer is ...

Подробнее
Номер записи: 64
09-01-2020 дата публикации

MASS SPECTROMETRY DEVICE AND MASS SPECTROMETRY METHOD

Номер: US20200013608A1
Автор: KOTANI Masahiro, NAITO Yasuhide, OHMURA Takayuki
Принадлежит: HAMAMATSU PHOTONICS K.K.

A mass spectrometry device according to one aspect of the invention includes: a sample stage on which a sample is placed and on which a sample support having a substrate, in which a plurality of through-holes passing from one surface thereof to the other surface thereof are provided, and a conductive layer, which covers at least a portion of the one surface which is not provided with the through-holes, is placed such that the other surface faces the sample; a laser beam application unit that controls application of a laser beam such that the laser beam is applied to an imaging target region on the one surface; and a detector that detects the sample ionized by the application of the laser beam in a state where a positional relation of the sample in the imaging target region is maintained. 18-. (canceled)9. A mass spectrometry device comprising:a sample stage on which a thin film-like sample subjected to imaging mass spectrometry is placed and on which a sample support having a substrate, in which a plurality of through-holes passing from one surface thereof to the other surface thereof are provided, and a conductive layer, which is formed of a conductive material and covers at least a portion of the one surface which is not provided with the through-holes, is placed such that the other surface faces the sample;a laser beam application unit configured to control application of a laser beam such that the laser beam is applied to an imaging target region on the one surface, the imaging target region being a portion or all of an effective region of the sample support which functions as a region for moving the sample from the other surface to the one surface due to a capillary phenomenon, and being a region that overlaps the sample when viewed in a thickness direction of the substrate; anda detection unit configured to detect the sample ionized by the application of the laser beam in a state where a positional relation of the sample in the imaging target region is ...

Подробнее
Номер записи: 65
16-01-2020 дата публикации

Reconfigurable Sequentially-Packed Ion (Spion) Transfer Device and System

Номер: US20200015717A1
Автор: TAGHIOSKOUI Mazdak
Принадлежит:

A method of analysis using mass spectrometry or ion mobility spectrometry that includes producing ions from a sample in a proximity of the sample, transferring the produced ions from the sample to a distance with a flexible or re-configurable ion guide, the flexible or re-configurable ion guide being connected to RF voltages, and separating the produced ions with a mass to charge or mobility analyzer located at the distance to provide spectrometric results; and detecting the separated ions with at least one detector. 1. A method for analyzing a sample using mass spectrometry or ion mobility spectrometry , the method comprising:producing gas-phase ions and neutrals from the sample in a proximity of the sample;transferring the produced ions from the sample to a distance via a flexible or re-configurable ion transfer device, the flexible or re-configurable ion transfer device employing RF voltages to transfer the ions;separating the produced ions with a mass spectrometer or a mobility analyzer located at the distance to provide spectrometric results; anddetecting the separated ions with at least one detector.2. The method according to claim 1 , wherein the sample is a biological sample of a human subject or a non-human animal subject claim 1 , or a specimen derived from said human or non-human animal subject.3. The method according to claim 2 , wherein the biological sample is in vivo tissue.4. The method according to claim 2 , further comprising:determining presence, type, grade, stage, or a combination thereof of a disease in one of more regions of the sample that is a biological sample based on the spectrometric results.5. The method according to claim 4 , wherein the determining is performed based on determining one or more biomarkers for the disease in the biological sample.6. The method according to claim 4 , wherein the disease is one or more cancers claim 4 , cancer tumors claim 4 , or tumor margins.7. The method according to claim 1 , further comprising: ...

Подробнее
Номер записи: 66
19-01-2017 дата публикации

METHOD OF TARGETED MASS SPECTROMETRIC ANALYSIS

Номер: US20170016863A1
Автор: Verenchikov Anatoly N.
Принадлежит: LECO Corporation

A method of targeted mass spectrometric analysis is provided for analyzing trace compounds at sub-ppb level compared to sample matrix. Sample is chromatographically separated at standard conditions to employ a map of target mass (M) versus retention time (RT). Small mass ions under M(RT) are rejected by RF field, and remaining ions are accumulated for pulsed injection into a multi-reflecting TOF MS, either directly from EI source, or from linear RF trap or via a heated RF only quadrupole with axial ion trapping. In combination with EI source the method provides sub femtogram sensitivity at matrices loads in microgram range. 1. A method of targeted mass spectrometric analysis for a sample comprising:establishing standard conditions for chromatographic separation, such that masses M of target compounds are mapped as a function of retention times RT;injecting and chromatographically separating the sample;ionizing the sample;removing low mass ions smaller than M(RT) by radio-frequency field;ion accumulating and pulsed ejecting via an electron beam or radiofrequency quadrupole or trap; andmass analyzing in multi-reflecting time-of-flight mass spectrometer MR-TOF MS.2. The method of claim 1 , further comprising:synchronized orthogonal pulsed acceleration.3. The method of claim 1 , wherein said step of chromatographic separation is arranged at large volume injections above about 1 uL of solvent.4. The method of claim 1 , wherein said step of chromatographic separation is arranged at Helium flow from at or substantially between 0.5 mL/min to 2 mL/min.5. The method of claim 1 , wherein said step of chromatographic separation is arranged at Helium flow from 2 mL/min to 20 mL/min and wherein the method further comprises:splitting the eluent in a differentially pumped stage prior to ionizing the sample.6. The method of claim 1 , wherein said step of ionization comprises one step selected from the group consisting of: (i) electron impact ionization (EI); (ii) chemical ionization ...

Подробнее
Номер записи: 67
21-01-2016 дата публикации

Method for monitoring level of paraben in cosmetics

Номер: US20160020077A1
Автор: Chi-Yu Lu, Yi-Hsuan Lee
Принадлежит: KAOHSIUNG MEDICAL UNIVERSITY

The invention discloses a method for monitoring level of paraben comprising: dissolving a sample in a solvent and obtaining a supernatant containing paraben by ultrasonic vibration and high speed centrifugation; performing a derivatization reaction between a derivatization reagent and paraben by adding the derivatization reagent into the supernatant to obtain a derivatization solution containing a tagged paraben; extracting the derivatization solution by an extractant to obtain an extract containing the tagged paraben; and ionizating the tagged paraben by a laser beam and analyzing mass-to-charge ratio of the tagged paraben by an analyzer to determine molecular weight thereof.

Подробнее
Номер записи: 68
21-01-2016 дата публикации

Charging Plate for Enhancing Multiply Charged Ions by Laser Desorption

Номер: US20160020079A1
Автор: Brown Jeffery Mark
Принадлежит:

A sample plate for an ion source is disclosed comprising a plurality of ionisation regions, each ionisation region comprising a first electrode and a second separate electrode separated by an insulator

Подробнее
Номер записи: 69
21-01-2016 дата публикации

SAMPLE PLATE FOR MALDI-TOF MASS SPECTROMETER AND METHOD OF MANUFACTURING THE SAMPLE PLATE AND MASS SPECTROMETRY METHOD USING THE SAMPLE PLATE

Номер: US20160020080A1
Автор: Kim Jo II, Pyun Jaechul
Принадлежит:

The present invention relates to a sample plate to be used for a MALDI-TOF (Matrix Assisted Laser Desorption Ionization Time of Flight) mass spectrometer, and more particularly, to a sample plate for a MALDI-TOF mass spectrometer, which is particularly useful for molecular weight measurement of a high-volatile material, a method of manufacturing the sample plate and a mass spectrometry method using the sample plate. Object of the present invention to provide a method capable of performing a mass spectrometry for a high-volatile material by using a MALDI-TOF mass spectrometer so as to overcome the limits of the gas chromatography method of the related art. According to the present invention, there is provided a sample plate including a target plate, an organic matrix formed on one surface of the target plate, a parylene thin film formed on the target plate having the organic matrix formed thereon and formed to cover the entire organic matrix, and a sample fixing layer formed on the parylene thin film. The sample fixing layer is made of at least one material selected from a group consisting of graphene and carbon nano tube (CNT).

Подробнее
Номер записи: 70
21-01-2016 дата публикации

Method to Perform Beam-Type Collision-Activated Dissociation in the Pre-Existing Ion Injection Pathway of a Mass Spectrometer

Номер: US20160020081A1
Автор: COON Joshua J., MCALISTER Graeme C.
Принадлежит: WISCONSIN ALUMNI RESEARCH FOUNDATION

Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dissociation methods. The methods can be practiced using a wide range of mass spectrometer configurations and allows MSexperiments to be performed on very basic mass spectrometers, even those without secondary mass analyzers and/or collision cells. Following injection and selection of a particular ion type or population, that population can be fragmented via beam-type collision-activated dissociation (CAD), as well as other dissociation methods, using the pre-existing ion injection pathway or inlet of a mass spectrometer. For CAD applications, this is achieved by transmitting the ions back along the ion injection pathway with a high degree of kinetic energy. As the ions pass into the higher pressure regions located in or near the atmospheric pressure inlet, the ions are fragmented and then trapped. Following fragmentation and trapping, the ions can either be re-injected into the primary ion selection device or sent on to a secondary mass analyzer.

Подробнее
Номер записи: 71
19-01-2017 дата публикации

PROCESS AND APPARATUS FOR MEASURING AN ORGANIC SOLID SAMPLE BY GLOW DISCHARGE SPECTROMETRY

Номер: US20170018417A1
Автор: CHAPON Patrick, LEGENDRE Sebastien, TEMPEZ Agnes
Принадлежит: HORIBA JOBIN YVON SAS

A system and a process for measuring, by glow discharge spectrometry, the elemental and/or molecular chemical composition of an organic solid sample (). The sample () is positioned so as to seal a glow discharge plasma reactor (), a gaseous mixture including at least one inert gas and gaseous oxygen is injected into the reactor (), the concentration of gaseous oxygen being between 0.1% and 15% by weight of the gaseous mixture, an electric discharge of radiofrequency type is applied to the electrodes of the plasma reactor () in order to generate a glow discharge plasma, and the solid sample () is exposed to the plasma so as to etch an erosion crater in the solid sample (); at least one signal representative of an ionized species of negative charge is selected and measured using a mass spectrometer (). 112-. (canceled)13. A method of measurement by glow discharge spectrometry of the elementary and/or molecular chemical composition of a solid sample including at least one organic or polymer layer , which comprises the following steps:arranging the sample so as to close a vacuum chamber of a glow discharge plasma reactor,injecting in the vacuum chamber a gaseous mixture comprising at least one rare gas and gaseous oxygen, the concentration in gaseous oxygen being comprised between 0.1 and 15 mass % of the gaseous mixture, an electric discharge adapted to generate a glow discharge plasma is applied to the electrodes of the reactor, so as to expose the solid sample to said plasma;selecting and measuring, by means of a mass spectrometer, at least one signal representative of an ionized species of negative charge.14. The method of measurement by glow discharge spectrometry according to claim 13 , wherein the at least one rare gas is chosen among argon claim 13 , neon claim 13 , krypton claim 13 , helium or a mixture of said rare gases.15. The method of measurement by glow discharge spectrometry according to claim 13 , wherein the solid sample includes a stack of organic or ...

Подробнее
Номер записи: 72
17-04-2014 дата публикации

METHOD AND APPARATUS FOR ANALYSIS AND ION SOURCE

Номер: US20140103205A1
Автор: Parr Victor Carl, Pollard Alex
Принадлежит: Scientific Analysis Instruments Limited

An ion source is formed by a chamber . A capillary tube forms an inlet to the chamber. A heater is associated with the capillary tube to heat air drawn into the chamber. An electrode is provided in the chamber and maintained at a voltage in the range 100 to 500 volts. In use the source is connected to an analyser such as a mass spectrometer . The capillary tube is open to the atmosphere. Pressure in the chamber is reduced, and pressure in the analyser is further reduced. An electrical potential is applied to the electrode to create a discharge within the chamber. Ionisation of air molecules within the chamber leads to ionisation of any sample molecules present in the chamber. Ions are swept into the analyser for analysis. 1. A method of ionising a sample for analysis including the steps of drawing atmospheric air containing the sample into a chamber in which the pressure is less than atmospheric pressure , heating the air and creating an electrical discharge by applying a DC electrical potential in the range 100-500 volts to an electrode in the chamber thereby to bring air molecules in the chamber into an excited state and permitting the excited state molecules to react with the sample to generate sample ions.2. A method as claimed in wherein the pressure in the chamber is less than 2 torr.3. A method as claimed in wherein the pressure in the chamber is about 1 torr.4. A method as claimed in wherein atmospheric air is drawn into the chamber through a capillary tube.5. A method as claimed in wherein the electrical potential is in the range 200-400 volts.6. A method as claimed in comprising the step of sweeping ions generated in the chamber into an analyser.7. A method as claimed in wherein the ions pass through a pressure step into the analyser claim 6 , into a region where the pressure is lower than that in the chamber.8. A method as claimed in wherein the pressure in the analyser is equal to or less than 10torr.9. A method as claimed in wherein the pressure in the ...

Подробнее
Номер записи: 73
03-02-2022 дата публикации

MASS SPECTROMETRY

Номер: US20220037141A1
Автор: SUHARA Hiroyuki, SUZUKI Kazumi, UEMATSU Katsuyuki
Принадлежит: RICOH COMPANY, LTD.

Provided is mass spectrometry including applying a laser beam to a matrix dot disposed on a surface of a measurement sample. One of: a laser spot appearing in the measurement sample when the laser beam is applied to the matrix dot; and the matrix dot, is completely enclosed in the other. 2. The mass spectrometry according to claim 1 ,wherein condition (A) is satisfied in which the laser spot appearing in the measurement sample when the laser beam is applied to the matrix dot is completely enclosed in the matrix dot.3. The mass spectrometry according to claim 2 ,wherein condition (A1): Md>Ld and condition (A2): ML<½ (Md-Ld) are satisfied, where:Md denotes a diameter of the matrix dot;Ld denotes a diameter of the laser spot; andML denotes a distance between a center Mc of the matrix dot and a center Lc of the laser spot.4. The mass spectrometry according to claim 2 , wherein the matrix dots and the laser spots of the laser beam applied are regularly arranged and an arrangement of the laser spots is in synchronization with an arrangement of the matrix dots.5. The mass spectrometry according to claim 2 , wherein the matrix dots disposed on the surface of the measurement sample are two or more kinds claim 2 , andtwo or more kinds of the matrix dots are disposed at mutually different positions on the surface of the measurement sample.6. The mass spectrometry according to claim 2 , wherein the laser beam used for forming the matrix dot is an optical vortex laser beam.7. The mass spectrometry according to claim 2 , wherein the laser beam used for forming the matrix dot is a uniformly heating irradiation laser beam.8. The mass spectrometry according to claim 2 , wherein the mass spectrometry is MALDI mass spectrometry.9. The mass spectrometry according to claim 1 ,wherein condition (B) is satisfied in which the matrix dot is completely enclosed in the laser spot appearing in the measurement sample when the laser beam is applied to the matrix dot.10. The mass spectrometry ...

Подробнее
Номер записи: 74
03-02-2022 дата публикации

Desorption ion source with dopant-gas assisted ionization

Номер: US20220037142A1
Автор: Christoph Hauke Manfred BOOKMEYER, Jens Soltwisch, Klaus Dreisewerd
Принадлежит: Bruker Daltonics GmbH and Co KG, WESTFAELISCHE WILHELMS UNIVERSITAET MUENSTER

Disclosed is a device to generate ions from a deposited sample, comprising: A chamber which is arranged and designed to keep the deposited sample in a conditioned environment comprising a dopant gas, A desorption device which is arranged and designed to desorb the deposited sample in the chamber using an energy burst, An ionization device which, for the purpose of ionization, is arranged and designed to irradiate the desorbed sample in the chamber using coherent electromagnetic waves or expose it to an electric discharge, a plasma, or light of an arc discharge lamp with broadband emission spectrum, which are chosen such that the dopant gas is receptive to them, and An extraction device which is arranged and designed to extract ions from the desorbed sample and transfer them into an analyzer. Disclosed is also a method which is preferably conducted on such a device.

Подробнее
Номер записи: 75
18-01-2018 дата публикации

ION TRANSFER TUBE FLOW AND PUMPING SYSTEM LOAD

Номер: US20180019111A1
Автор: MAZE Joshua T., McCAULEY Edward B., Quarmby Scott T.
Принадлежит:

A mass spectrometer system can include an ion source, a vacuum chamber; a mass analyzer within the vacuum chamber, a transfer tube between the ion source and the vacuum chamber, a transfer tube heater, and a vacuum pump. The mass spectrometer system can be configured to reduce the pump speed of the vacuum pump in response to receiving a transfer tube swap instruction; lower the temperature of the transfer tube to below a first threshold; operating the vacuum pump at the reduced pump speed while the transfer tube is replaced with a second transfer tube; heating the second transfer tube to a temperature above a pump down temperature; and increasing the pump speed of the vacuum pump after the temperature of the second transfer tube exceeds a second threshold. 1. A mass spectrometer system comprising:an ion source, the ion source configured to produce ions from a sample;a vacuum chamber;a mass analyzer within the vacuum chamber, the mass analyzer configured to determine mass-to-charge ratios for ions from the sample;a first transfer tube between the ion source and the vacuum chamber, the transfer tube configured to allow passage of the ions from the ion source to the vacuum chamber;a transfer tube heater configured to heat the transfer tube to and maintain the transfer tube at an operating temperature;a vacuum pump configured to maintain the vacuum chamber at a low pressure; controlling the transfer tube heater to maintain the first transfer tube at the operating temperature and the vacuum pump to maintain the vacuum chamber at an operating pressure;', 'reducing the pump speed of the vacuum pump in response to receiving a transfer tube swap instruction;', 'lowering the temperature of the first transfer tube to below a first threshold;', 'operating the vacuum pump at the reduced pump speed while the first transfer tube is replaced with a second transfer tube to maintain the vacuum chamber at a pressure between atmospheric pressure and the operating pressure;', 'heating a ...

Подробнее
Номер записи: 76
22-01-2015 дата публикации

Interfacing Capillary Electrophoresis to a Mass Spectrometer via an Impactor Spray Ionization Source

Номер: US20150021469A1
Автор: Bajic Stevan
Принадлежит: MICROMASS UK LIMITED

A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a Capillary Electrophoresis (“CE”) separation device. The mass spectrometer further comprises a nebuliser and a target. Eluent emitted by the separation device is nebulised, in use, by the nebuliser wherein a stream of analyte droplets are directed to impact upon the target so as to ionise the analyte to form a plurality of analyte ions. 1. A mass spectrometer comprising:a separation device arranged and adapted to emit an eluent over a period of time, wherein said separation device comprises either: (i) a Capillary Electrophoresis (“CE”) separation device; (ii) a Capillary Electrochromatography (“CEC”) separation device; (iii) a substantially rigid ceramic-based multilayer microfluidic substrate (“ceramic tile”) separation device; or (iv) a supercritical fluid chromatography separation device;a nebuliser and;a target;wherein said eluent emitted by said separation device is nebulised, in use, by said nebuliser wherein a stream of analyte droplets are directed to impact upon said target so as to ionise said analyte to form a plurality of analyte ions; andwherein said mass spectrometer further comprises a control system, wherein said control system is arranged and adapted either: (i) to switch the polarity of said target during a single experimental run; or (ii) to repeatedly switch the polarity of said target during a single experimental run.2. A mass spectrometer as claimed in claim 1 , wherein said separation device comprises a Capillary Electrophoresis (“CE”) separation device wherein an inlet end of said Capillary Electrophoresis separation device is maintained at a first potential and an outlet end of said Capillary Electrophoresis separation device is maintained at a second potential.3. A mass spectrometer as claimed in claim 1 , wherein said separation device comprises or is coupled to a first ...

Подробнее
Номер записи: 77
22-01-2015 дата публикации

Collision Cell for Tandem Mass Spectrometry

Номер: US20150021472A1
Автор: MAKAROV Alexander Alekseevich
Принадлежит:

A method and apparatus for tandem mass spectrometry is disclosed. Precursor ions are fragmented and the fragments are accumulated in parallel, by converting an incoming stream of ions from an ion source () into a time separated sequence of multiple precursor ions which are then assigned to their own particular channel of a multi compartment collision cell (). In this manner, precursor ion species, being allocated to their own dedicated fragmentation cell chambers () within the fragmentation cell (), can then be captured and fragmented by that dedicated fragmentation chamber at optimum energy and/or fragmentation conditions. 1. A method of tandem mass spectrometry comprising:generating ions to be analysed, from an ion source;separating the generated ions into a sequence of precursor ions separated in time in accordance with their mass to charge ratio;{'sub': i', 'i, 'sup': 'th', 'directing ions of a mass to charge ratio Mat a time tinto an ione of a plurality of N spatially separated fragmentation cell chamber arranged in parallel with one another in a fragmentation cell;'}{'sup': 'th', 'fragmenting ions in the ichamber;'}{'sub': j', 'j, 'sup': 'th', 'directing ions of a mass to charge ratio Mat a time t, into a jone of the plurality of N spatially separated parallel fragmentation cell chambers;'}{'sup': 'th', 'fragmenting ions in the jchamber;'}ejecting fragment ions and any remaining precursor ions from each of the fragmentation cell chambers to a mass analyser; andanalysing ions from each chamber in the mass analyser.2. The method of claim 1 , wherein ions of at least two different masses M claim 1 , Mare fragmented and stored in respective ones of the spatially separated fragmentation cell chambers at partially overlapping times.3. The method of claim 1 , wherein the step of ejecting fragment ions and remaining precursor ions comprises:{'sub': 'N', 'sup': 'th', '(a) in a first cycle ejecting ions containing and/or fragmented from precursors of mass Mfrom an None ...

Подробнее
Номер записи: 78
17-01-2019 дата публикации

SAMPLE MOUNTING PLATE AND METHOD FOR MANUFACTURING THE SAME

Номер: US20190019661A1
Автор: Kuratomi Tomoki, Toriumi Kazuhiro
Принадлежит:

A sample mounting plate which is used for mass spectrometry according to MALDI process and which is provided with at least one sample loading spot for mounting a sample on a substrate, wherein: a hydrophilic surface produced by a first hydrophilic film is formed within the sample loading spot on a surface of the substrate provided with the sample loading spot; a hydrophobic surface produced by a hydrophobic film is formed on the outside of the hydrophilic surface; and a boundary part, in which a hydrophilic member or a second hydrophilic film having a higher hydrophilicity than the first hydrophilic film is exposed, is formed at the boundary between the hydrophilic surface and the hydrophobic surface. 1. A sample mounting plate used for mass spectrometry by MALDI process and comprising one or more sample mounting spots for mounting a sample thereon , on a substrate , whereina hydrophilic surface of a first hydrophilic film is formed in the sample mounting spots on a face of the substrate where the sample mounting spots are provided, a hydrophobic surface of a hydrophilic film is formed outside the hydrophilic surface, and a boundary part of a second hydrophilic film or a hydrophilic member, which has higher hydrophilicity than that of the first hydrophilic film, is formed at a boundary between the hydrophilic surface and the hydrophobic surface.2. The sample mounting plate according to claim 1 , wherein the first hydrophilic film is a metal film.3. The sample mounting plate according to claim 1 , wherein the first hydrophilic film is an optical multilayer film.4. The sample mounting plate according to claim 1 , wherein the second hydrophilic film or hydrophilic member is the substrate.5. The sample mounting plate according to claim 1 , wherein the second hydrophilic film or hydrophilic member is a film formed between the substrate and the first hydrophilic film.6. The sample mounting plate according to claim 5 , wherein the second hydrophilic film or hydrophilic ...

Подробнее
Номер записи: 79
17-01-2019 дата публикации

ORTHOGONAL ACCELERATION TIME-OF-FLIGHT MASS SPECTROMETRY

Номер: US20190019664A1
Автор: FURUHASHI Osamu, Okumura Daisuke, OSHIRO Tomoyuki
Принадлежит: SHIMADZU CORPORATION

A multipole ion guide () including a plurality of rod electrodes arranged at an angle to the central axis (C) is placed within a collision cell () located in the previous stage of an orthogonal accelerator (). Radio-frequency voltages with opposite phases are applied to the rod electrodes of the ion guide () so that any two rod electrodes neighboring each other in the circumferential direction have opposite phases of the voltage. A depth gradient of the pseudopotential is thereby formed from the entrance end toward the exit end within the space surrounded by the rod electrodes, and ions are accelerated by this gradient. During an ion-accumulating process, a direct voltage having the same polarity as the ions is applied to the exit lens electrode () to form a potential barrier for accumulating ions. Among the ions repelled by the potential barrier, ions having smaller m/z return closer to the entrance end. Therefore, when the potential barrier is removed and ions are discharged, ions having smaller m/z are discharged at later points in time than those having larger m/z. Therefore, a wide m/z range of ions can be simultaneously accelerated and ejected by an orthogonal accelerator (). 1. An orthogonal acceleration time-of-flight mass spectrometer including an orthogonal accelerator for accelerating and ejecting ions in a direction orthogonal to an axis of incidence of ions originating from a sample and a separating-detecting section for separating and detecting the ejected ions according to their times of flight which depend on mass-to-charge ratios of the ions , the orthogonal acceleration time-of-flight mass spectrometer comprising: a1) an ion guide including a plurality of rod electrodes arranged in such a manner as to surround a central axis, for converging ions within a space surrounded by the rod electrodes by an effect of a radio-frequency electric field, and for accelerating the ions in a direction along the central axis by a gradient of the magnitude or depth ...

Подробнее
Номер записи: 80
16-01-2020 дата публикации

SYSTEMS AND METHODS FOR CONDUCTING REACTIONS AND SCREENING FOR REACTION PRODUCTS

Номер: US20200020516A1
Автор: Cooks Robert Graham
Принадлежит:

The invention generally relates to systems and methods for conducting reactions and screening for reaction products. 1. A system for conducting reactions and screening for reaction products , the system comprising:a sampling probe configured to produce a liquid droplet spray discharge;a substrate configured to hold reagents for a reaction; anda mass spectrometer, wherein the system is configured such that the sampling probe produces the liquid droplet spray discharge toward the substrate at an angle that the liquid droplet spray discharge impacts the substrate in order to desorb the reagents from the substrate and reflects the liquid droplet spray discharge from the substrate to an inlet of the mass spectrometer, which inlet is positioned a distance from the substrate such that the reagents desorbed into the liquid droplet spray discharge have sufficient time to react and form a reaction product prior to the liquid droplet spray discharge reaching the inlet of the mass spectrometer.2. The system according to claim 1 , wherein the sampling probe is a desorption electrospray ionization probe and the liquid droplet spray discharge is a desorption electrospray ionization active discharge.3. The system according to claim 1 , wherein the sampling probe comprises a gas source and a voltage source.4. The system according to claim 1 , wherein the mass spectrometer is a bench-top mass spectrometer or a miniature mass spectrometer.5. The system according to claim 1 , wherein a rate of the reaction among the reagents in the liquid droplet spray discharge is accelerated as compared to a rate of the reaction among the reagents in a bulk liquid.6. The system according to claim 1 , wherein the substrate comprises a plurality of discrete locations claim 1 , one or more of which discrete locations include reagents for a reaction.7. The system according to claim 6 , wherein the substrate is a movable substrate.8. The system according to claim 7 , wherein the movable substrate is ...

Подробнее
Номер записи: 81
21-01-2021 дата публикации

Integrated electrospray ion source

Номер: US20210020423A1
Автор: Bradley B. Schneider, John J. Corr, Peter Kovarik, Thomas R. Covey
Принадлежит: DH TECHNOLOGIES DEVELOPMENT PTE LTD

In one aspect, an ion source for use in a mass spectrometry system is disclosed, which comprises a housing, a first and a second ion probe coupled to said housing, and a first and a second emitter configured for coupling, respectively, to said first and second ion probes. The first ion probe is configured for receiving a sample at a flow rate in nanoflow regime and the second ion probe is configured for receiving a sample at a flow rate above the nanoflow regime. Each of the ion probes includes a discharge end (herein also referred to as the discharge tip) for ionizing at least one constituent of the received sample. In some embodiment, each ion probe receives the sample from a liquid chromatography (LC) column. Further, the ion probes can be interchangeably disposed within the housing.

Подробнее
Номер записи: 82
25-01-2018 дата публикации

Method for multiplexed sample analysis by photoionizing secondary sputtered neutrals

Номер: US20180024111A1
Автор: Robert M. ANGELO
Принадлежит: Leland Stanford Junior University

Disclosed herein is a method of generating a high resolution image of a cellular sample, the method including i) labeling a cellular sample with at least one mass tag, thereby producing a labeled sample in which a biological feature of interest is associated with the at least one mass tag, ii) scanning the sample with a continuous or near-continuous primary ion beam to generate sputtered secondary ions and sputtered neutral species, iii) photoionizing the sputtered neutrals to generate ionized neutral species, wherein the sputtered neutrals are photoionized at a site that is proximal to their source on the sample, iv) detecting the ionized neutral species by mass spectrometry, thereby obtaining spatially addressed measurements of the abundance of the at least one mass tag across an area of the sample, and v) producing an image of the sample using the measurements. A system for performing the method is also provided.

Подробнее
Номер записи: 83
26-01-2017 дата публикации

Electrospray Ionization Source and LC-MS Interface

Номер: US20170025262A1
Автор: HE Muyi, Hu Lili, XU WEI, ZHANG Zezhen
Принадлежит:

The present invention provides an electrospray ionization source, which includes: a capillary, including a spray tip; a first electrode which provides the spray tip with a spray voltage; and a second electrode. The electrical potential difference between the first electrode and the second electrode forms a separation electric field, which allows the electric field separation and electrospray ionization of the sample to be accomplished simultaneously, thereby improving the sensitivity of detection. 1. An electrospray ionization source comprising:a capillary comprising a spray tip;a first electrode providing the spray tip of the capillary with a spray voltage; anda second electrode, wherein the electrical potential difference between the first electrode and the second electrode forms a separation electric field.2. The electrospray ionization source according to claim 1 , wherein said first electrode and second electrode each has a front end claim 1 , and wherein the distance of the front end of said second electrode from the spray tip of said capillary is greater than the distance of the front end of said first electrode from the spray tip of said capillary.3. The electrospray ionization source according to claim 1 , wherein said first and second electrodes are each independently selected from the group consisting of a linear electrode claim 1 , an L-shaped electrode claim 1 , an annular electrode claim 1 , and a cylindrical sleeve-shaped electrode.4. The electrospray ionization source according to claim 1 , wherein said first and second electrodes are each independently selected from the group consisting of a metal electrode claim 1 , a nonmetal electrode claim 1 , and a composite material electrode.5. The electrospray ionization source according to claim 1 , wherein either or both said first electrode and the second electrodes have an outer surface with an insulating coating.6. The electrospray ionization source according to claim 1 , wherein each of said first and ...

Подробнее
Номер записи: 84
26-01-2017 дата публикации

INTEGRATED SAMPLE PROCESSING FOR ELECTROSPRAY IONIZATION DEVICES

Номер: US20170025263A1
Автор: Batz Nicholas George, Mellors John Scott, Ramsey John Michael
Принадлежит:

Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one ESI emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one ESI emitter thereby preferentially directing analyte molecules out of the at least one ESI emitter. The methods, systems and devices are particularly suitable for use with a mass spectrometer. 1. (canceled)2. A method of separating a target and a non-target component of a sample , the method comprising:providing the sample in an electrolyte solution in a first fluidic channel, the first fluidic channel comprising first and second opposed ends, and connected in proximity to the second end to a second fluidic channel also comprising the electrolyte solution;{'sub': '1', 'applying a first electrical potential difference between two points in the first fluidic channel to cause electroosmotic flow of the electrolyte solution in the first fluidic channel at a rate of magnitude Rtoward the first end; and'}{'sub': 2', '1, 'applying a second electrical potential difference between two points in the second fluidic channel to cause electroosmotic flow of the electrolyte solution in the second fluidic channel at a rate of magnitude R>Rtoward the second end,'}wherein applying the first electrical potential difference causes the target component of the sample to migrate toward the second end, thereby separating the target and non-target components.3. The method of claim 2 , wherein Ris at least 20% larger than R.4. The method of claim 2 , wherein the target component comprises a protein.5. The ...

Подробнее
Номер записи: 85
26-01-2017 дата публикации

Device for mass spectrometry

Номер: US20170025264A1
Автор: Jiruse Jaroslav, SEDLACEK Libor
Принадлежит: TESCAN Brno, s.r.o.

A device for mass spectrometry in continuous operation can be equipped with a focused electron beam source or laser radiation source. It can further include a vacuum chamber, a stage for placing the specimen, and an ion beam column with a plasma source for producing a primary ion beam and a secondary ion mass spectrometer for secondary ion analysis. The ion beam column is connected to an inert gas source and to a reactive gas source and is modified for simultaneous introduction of at least two gases from the inert gas source and reactive gas source. The secondary ion mass spectrometer is of an orthogonal Time-of-Flight type to ensure the function with the ion beam column in continuous operation. 1. Device for mass spectrometry including a vacuum chamber , stage for placing a specimen , ion beam column with a plasma source for producing primary ion beam and a secondary ion mass spectrometer for analyzing secondary ions , wherein the ion beam column is connected to the inert gas source and the reactive gas source , wherein at least two gasses are continuously introduced from the inert gas source and the reactive gas source , and that the secondary ion mass spectrometer is of an orthogonal Time-Of-Flight type to ensure the function with the ion beam column in continuous operation.2. Device for mass spectrometry according to claim 1 , wherein the plasma source is of an Electron Cyclotrone Resonance type.3. Device for mass spectrometry according to claim 1 , wherein the ion beam column produces a focused ion beam.4. Device for mass spectrometry according to claim 1 , wherein the reactive gas source is an oxygen source.5. Device for mass spectrometry according to claim 1 , wherein the inert gas source is xenon source.6. Device for mass spectrometry according to claim 1 , wherein the inert gas source is argon source.7. Device for mass spectrometry according to claim 1 , wherein the inert gas source is helium source.8. Device for mass spectrometry according to claim 1 , ...

Подробнее
Номер записи: 86
28-01-2016 дата публикации

Automated Tuning for MALDI Ion Imaging

Номер: US20160027625A1
Автор: Brown Jeffery Mark, MURRAY Paul
Принадлежит:

A method of ion imaging is disclosed comprising testing a first portion of a sample by automatically varying one or more parameters of a laser or other ionisation device and manually or automatically determining from the first portion one or more optimum or preferred parameters of the laser or other ionisation device. A second portion of the sample is then analysed using the one or more optimum or preferred parameters. 1. A method of ion imaging comprising:testing a first portion of a sample by automatically varying one or more parameters of an ionisation device;manually or automatically determining from the first portion one or more optimum or preferred parameters of said ionisation device; and then analysing a second portion of said sample using said one or more optimum or preferred parameters;wherein said first portion comprises a test portion or sacrificial region of said sample, and said second portion comprises a remaining portion of said sample.2. (canceled)3. A method as claimed in claim 1 , wherein the step of testing said first portion of said sample comprises obtaining data from an array of pixels across said first portion.4. A method as claimed in claim 3 , further comprising manually or automatically determining which pixel corresponds with the greatest claim 3 , optimal or preferred intensity of ions of interest.5. A method as claimed in claim 4 , further comprising manually or automatically determining one or more parameters of said laser or other ionisation device which result in the greatest claim 4 , optimal or preferred intensity of ions of interest.6. A method as claimed in claim 1 , wherein said ionisation device comprises a laser claim 1 , and the step of automatically varying said one or more parameters comprises automatically varying the number of laser shots per pixel.7. A method as claimed in claim 1 , wherein said ionisation device comprises a laser claim 1 , and the step of automatically varying said one or more parameters comprises ...

Подробнее
Номер записи: 87
28-01-2016 дата публикации

Filament for mass spectrometric electron impact ion source

Номер: US20160027630A1
Автор: Felician Muntean, Maurizio Splendore, Roy P. Moeller
Принадлежит: Bruker Daltonics Inc

The invention provides a cathode system for an Electron Ionization (EI) source comprising a filament and current supply posts, the current supply posts dividing the filament into segments and each current supply post supplying or returning the current for at least two segments of the filament. Each filament segment is connected, for instance by spot welding, to the supply posts delivering the heating current. The filament segments may be arranged in a row, or substantially parallel to each other. Filament segments arranged in a row may form a closed loop, for instance, a ring. Other embodiments encompass the filament shape of a helical coil.

Подробнее
Номер записи: 88
28-01-2016 дата публикации

MEASUREMENT DEVICE, MEASUREMENT APPARATUS, AND METHOD

Номер: US20160027631A1
Автор: NAYA Masayuki, SHIOTA Megumi, SUEMATSU Makoto, YAMAZOE Shogo
Принадлежит: FUJIFILM Corporation

A metal film of a measurement device including a transparent dielectric substrate is irradiated with first light from a transparent dielectric substrate side, an optical electric field enhanced by an optical electric field enhancing effect of a localized plasmon induced to a surface of the metal film by the irradiation is generated, light emitted from the transparent dielectric substrate side is detected, a specimen installed on a surface of a metal fine concavo-convex structure layer and a matrix agent are irradiated with second light from a side opposite to the side of the irradiation with the first light in a state where a voltage is applied to the metal fine concavo-convex structure layer through a voltage application electrode, an analysis target substance for mass spectrometry in the specimen is desorbed from the surface by the irradiation, and the desorbed analysis target substance is detected. 1. A measurement device comprising:a transparent dielectric substrate that is constituted of a dielectric having a transparent fine concavo-convex structure in a surface thereof; anda metal fine concavo-convex structure layer that is configured by forming a metal film on a surface of the fine concavo-convex structure,wherein the metal fine concavo-convex structure layer allows electrical conduction within the metal fine concavo-convex structure layer, andwherein a voltage application electrode for applying a voltage to the metal fine concavo-convex structure layer is provided.2. The measurement device according to claim 1 , wherein a surface resistivity of the metal fine concavo-convex structure layer is equal to or less than 10Ω/cm.3. The measurement device according to claim 1 , wherein the fine concavo-convex structure is formed of boehmite.4. The measurement device according to claim 1 , wherein the metal film is formed of at least one metal selected from a group consisting of Au claim 1 , Ag claim 1 , Cu claim 1 , Al claim 1 , Pt claim 1 , and an alloy containing ...

Подробнее
Номер записи: 89
28-01-2016 дата публикации

Collision Cell Multipole

Номер: US20160027633A1
Автор: Jung Gerhard, ROTTMANN Lothar
Принадлежит:

Mass spectrometer collision/reaction cell multipole and method. The multipole may have first and second portions and an intermediate portion therebetween, the first and second portions operating at first and second q values lower than a third q value at the intermediate portion. A low-mass cut-off of the multipole may be controlled by varying a q value from a first to at least a second value. The multipole may have multipole electrodes disposed about a central axis and having a respective first portion, second portion, and intermediate portion therebetween which is radially closer to the central axis. This offers relatively high acceptance and ion transmission, while providing low-mass cut-off for removing undesired/interfering ions and helping reduce background count. 1. A collision cell multipole , the multipole comprising a plurality of multipole electrodes disposed about a central axis , at least some of the multipole electrodes having a respective first portion , second portion , and intermediate portion therebetween , wherein the intermediate portion is radially closer to the central axis than its respective first portion and second portion.2. The collision cell multipole of claim 1 , wherein the at least some of the multipole electrodes comprise one or more respective pairs of radially opposing electrodes in the multipole.3. The collision cell multipole of claim 1 , wherein the first portion comprises a respective first end and the second portion comprises a respective second end claim 1 , the intermediate portion comprising a respective central portion of the electrode.4. The collision cell multipole of claim 3 , wherein the central portion is radially closest to the central axis.5. The collision cell multipole of claim 3 , wherein the first and second ends are radially furthest from the central axis.6. The collision cell multipole of claim 1 , wherein the first and second portions are a radial distance of 4.5 mm from the central axis.7. The collision cell ...

Подробнее
Номер записи: 90
24-01-2019 дата публикации

DETERMINATION OF ORGANIC SILICON IN HYDROCARBONACEOUS STREAMS

Номер: US20190025220A1
Автор: Al-Sabawi Mustafa, Mitchell Lindsay A.
Принадлежит:

Systems and methods are provided for determining the organic silicon content of petroleum fractions, such as refinery fractions. This can be achieved in part based on performing solvent-enhanced selective filtration on a hydrocarbonaceous sample to substantially remove inorganic silicon from the sample while retaining at least a substantial portion of the organic silicon in the sample. After the solvent-enhanced selective filtration, the organic silicon content of the filtered sample can be determined. The ability to determine the organic silicon content of a sample can be used to identify crude fractions and/or refinery fractions that may cause contamination problems within a refinery while reducing or minimizing the occurrence of false positive tests that could result from detection of inorganic silicon. 1. A method for determining the silicon content of a hydrocarbonaceous sample , comprising:mixing a hydrocarbonaceous sample with an aromatic solvent to form a mixture, the mixture comprising about 20 wt % to about 80 wt % of an aromatic solvent relative to a weight of the mixture;performing a solids removal process on the mixture suitable for removing particles having a particle size of about 1.0 μm or larger to form a reduced solids mixture; andcharacterizing the silicon content of the hydrocarbonaceous sample using a detection method comprising inductively coupled plasma.2. The method of claim 1 , wherein characterizing the silicon content of the hydrocarbonaceous sample comprises:separating a first fraction comprising a majority of the aromatic solvent and a second fraction comprising a majority of the silicon content from the reduced solids mixture; andcharacterizing the silicon content of the second fraction.3. The method of claim 2 , wherein separating a first fraction comprising a majority of the aromatic solvent from the reduced solids mixture comprises performing a separation based on distillation claim 2 , evaporation claim 2 , or a combination thereof. ...

Подробнее
Номер записи: 91
24-01-2019 дата публикации

PEPTIDE SEQUENCING DIRECTLY FROM SOLID SURFACES

Номер: US20190025324A1
Автор: Zhao Zhan-Gong
Принадлежит:

Method and system for sequence analysis directly on a solid surface that is both high speed and high throughput are described herein, utilizing equipment available in most protein analysis facilities. For example, surface bound peptides, selectively labeled at their N-termini with a positive charge-bearing group, are subjected to controlled degradation in ammonia gas, resulting in a concatenated set of charged peptide fragments that differ by a single amino acid. The fragments are taken up in a small volume of matrix solution and analyzed by matrix assisted laser desorption/ionization (MALDI) mass spectrometry. The peptide sequences can be read directly from the resulting spectra. 1. A method for sequencing a peptide , comprising:derivatizing the peptide containing N peptide bonds;cleaving the derivatized peptide into a set of peptide fragments, wherein the set of peptide fragments are generated by cleaving at each of the N peptide bonds;sequencing the set of peptide fragments to yield a peptide sequence of said peptide.2. The method of claim 1 , wherein the peptide is coupled to a solid surface.3. The method of claim 2 , wherein the peptide is synthesized in situ on the solid surface.4. The method of claim 2 , wherein the peptide is obtained from protein digestion and attached to the solid surface.5. The method of claim 2 , wherein the solid surface is a resin bead.6. The method of claim 2 , wherein the solid surface is a peptide microarray claim 2 , wherein the microarray comprises a glass or on a silicon wafer.7. The method of claim 1 , wherein the set of peptide fragments comprises various lengths.8. The method of claim 1 , wherein the derivatizing step comprises attaching a positive charge-bearing group to a N-terminus of a peptide.9. The method of claim 8 , wherein the positive charge-bearing group is N-Tris(2 claim 8 ,4 claim 8 ,6-trimethoxypheyl)phosphonium acetic acid (TMPP).10. The method of claim 8 , wherein the positive charge-bearing group is ...

Подробнее
Номер записи: 92
29-01-2015 дата публикации

Device for supplying voltage to the cathode of a mass spectrometer

Номер: US20150028743A1
Автор: Norbert Rolff
Принадлежит: Inficon GmbH Deutschland

A simplified device for voltage supply of the cathode of a mass spectrometer comprises a push-pull transformer, wherein, apart from the normal rectifier diodes ( 7, 9 ), a controlled rectifier ( 8, 10 ) is provided. The gate of the first transistor ( 8 ) is connected to the second output ( 30 ), and the gate of the second transistor ( 10 ) is connected to the first output ( 32 ) of the transformer. A voltage supply device, consisting of at least one voltage multiplier, is connected via capacitors ( 13, 14, 15 ) to the output of the transformer and feeds, amongst others, the emission current measurement device.

Подробнее
Номер записи: 93
23-01-2020 дата публикации

Device and system for selective ionization and analyte detection and method of using the same

Номер: US20200025715A1
Автор: Blandina Valenzuela, Eric Freeburg, Robert Ewing
Принадлежит: Battelle Memorial Institute Inc

Disclosed herein are embodiments of a system for selectively ionizing samples that may comprise a plurality of different analytes that are not normally detectable using the same ionization technique. The disclosed system comprises a unique split flow tube that can be coupled with a plurality of ionization sources to facilitate using different ionization techniques for the same sample. Also disclosed herein are embodiments of a method for determining the presence of analytes in a sample, wherein the number and type of detectable analytes that can be identified is increased and sensitivity and selectivity are not sacrificed.

Подробнее
Номер записи: 94
10-02-2022 дата публикации

GAS ANALYZER APPARATUS

Номер: US20220044919A1
Автор: Murthy Prakash Sreedhar, TAKAHASHI Naoki
Принадлежит: ATONARP INC.

There is provided a gas analyzer apparatus including: a sample chamber which is equipped with a dielectric wall structure and into which only sample gas to be measured is introduced; a plasma generation mechanism that generates plasma inside the sample chamber, which has been depressurized, using an electric field and/or a magnetic field applied through the dielectric wall structure; and an analyzer unit that analyzes the sample gas via the generated plasma. By doing so, it is possible to provide a gas analyzer apparatus capable of accurately analyzing sample gases, even those including corrosive gas, over a long period of time. 1. A gas analyzer apparatus comprising:a sample chamber which is equipped with a dielectric wall structure and into which only a sample gas to be measured is introduced;a plasma generation mechanism that generates plasma in the sample chamber that has been depressurized, using an electric field and/or a magnetic field applied through the dielectric wall structure; andan analyzer unit that analyzes the sample gas via the generated plasma.2. The gas analyzer apparatus according to claim 1 ,further comprising a gas input unit configured to introduce only the sample gas from a process into the sample chamber.3. The gas analyzer apparatus according to claim 1 ,wherein the dielectric wall structure includes at least one of quartz, aluminum oxide, and silicon nitride.4. The gas analyzer apparatus according to claim 1 ,wherein the plasma generation mechanism includes a mechanism for generating plasma using at least one of inductively coupled plasma, dielectric barrier discharge, and electron cyclotron resonance.5. The gas analyzer apparatus according to claim 1 ,wherein the sample chamber has a total length of 1 to 100 mm and a diameter of 1 to 100 mm.6. The gas analyzer apparatus according to claim 1 ,wherein the analyzer unit includes:a filter unit that filters ionized gas present in the plasma; anda detector unit that detects filtered ions.7. The ...

Подробнее
Номер записи: 95
10-02-2022 дата публикации

METHODS AND SYSTEMS FOR DETECTING AEROSOL PARTICLES

Номер: US20220044921A1
Автор: Arce Gonzalo, Berkout Vadym, Cornish Tim, Ecelberger Scott, Kliegman Ross, McLoughlin Michael, Regan Kyle
Принадлежит: Zeteo Tech, Inc.

Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles. A continuous timing laser tightly coupled with a pulse ionization laser is used to index aerosol particles, measure particle properties, and trigger the ionization laser to fire when each particle enters the beam of the trigger laser. Ionized fragments and optionally photons produced when each particle is struck by the ionization laser are analyzed using one or more detectors including a TOF-MS detector and an optical detector. Individual single particle spectra are aligned and denoised prior to averaging. 1. A system to identify the composition of aerosolized particles , the system comprising:an aerosol beam generator to generate a beam of single particles;a continuous timing laser generator to generate a timing laser to index each particle in the beam;a pulse ionization laser generator triggered by the timing laser and configured to generate at least one of an IR laser pulse and a UV laser pulse to strike each indexed particle when it reaches an ionization region of the ionization laser to produce at least one of ionized fragments of each indexed particle and photons associated with each indexed particle;a guide tube having an outlet end and disposed between the aerosol beam generator and the ionization region to urge particles to flow near about the longitudinal axis of the guide tube; and,at least one detector to analyze at least one of ionized fragments and photons associated with each particle and generate unique spectral data associated with each indexed particle.2. The system of wherein the size of the ionization region is between about 100 μm and 150 μm.3. The system of wherein the nominal inside diameter of the guide tube is about twice the size of the ionization region.4. The system of wherein the nominal length of the guide tube is between about 1 in. and about 5 in.5. The system of wherein the nominal length of the ...

Подробнее
Номер записи: 96
24-01-2019 дата публикации

Sample mounting plate and method for manufacturing the same

Номер: US20190027352A1
Автор: Kazuhiro Toriumi, Mitsunori Miyamoto, Satoru Fukumoto
Принадлежит: Citizen Fine Device Co Ltd, Citizen Watch Co Ltd

A sample loading plate that includes at least one sample mounting spot that mount a sample thereon is provided with a substrate having a conductive surface and an insulating film that is laminated on the conductive surface of the substrate and that has at least an insulating surface, the insulating film being sparsely formed so that the conductive surface of the substrate is partially exposed at least in the sample mounting spot. Thus, a voltage applied to the sample loading plate can effectively place the sample in an electric field. As a result of which, in a mass spectrometric analysis of the sample, there is no charge up of the sample and appropriate ionization becomes possible.

Подробнее
Номер записи: 97
23-01-2020 дата публикации

Planar ion sources for spectrometers

Номер: US20200027711A1
Автор: Benjamin D. Gardner, Gary Eiceman, Hsien-chi W. Niu
Принадлежит: Hamilton Sundstrand Corp

An apparatus for separating and analyzing ions includes a detector, a planar ion drift tube coupled to the detector and having a width, and a planar ion source. The planar ion source is coupled to the ion drift tube on an end of the ion drift tube opposite the detector and has a span greater than or equal to the width of the ion drift tube to ionize an analyte gas and fragment the analyte gas ions prior to admittance to the ion drift tube. Chemical detectors and methods of chemical detection are also described.

Подробнее
Номер записи: 98
01-02-2018 дата публикации

ELECTROSTATIC ATOMIZING DEVICE

Номер: US20180029053A1
Автор: AONO Tetsunori, IMAHORI Osamu, Ishigami Youhei, Nakada Takayuki, Omori Takafumi, YAMAGUCHI Tomohiro
Принадлежит:

An electrostatic atomizing device of the present disclosure includes a discharge electrode, a counter electrode, a liquid supplying unit, a current path, a voltage applicator, and a limiting resistor. The limiting resistor is disposed on a first current path or a second current path included in the current path. The first current path electrically connects the voltage applicator and the counter electrode, and the second current path electrically connects the voltage applicator and the discharge electrode. This makes it possible to increase an amount of generated radicals while keeping an increase of ozone small. In addition, an electric current peak of an instantaneous electric current can be kept small. 1. An electrostatic atomizing device comprising:a discharge electrode;a counter electrode that is located so as to face the discharge electrode;a liquid supplying unit that supplies a liquid for electrostatic atomization to the discharge electrode;a current path that electrically connects the discharge electrode and the counter electrode;a voltage applicator that is disposed on the current path, applies a voltage across the discharge electrode and the counter electrode, and thus intermittently generates a discharge path due to dielectric breakdown so that the discharge electrode and the counter electrode are connected to each other; anda limiting resistor that is disposed on the current path;whereinthe limiting resistor is disposed on a first current path or a second current path included in the current path, the first current path electrically connecting the voltage applicator and the counter electrode, and the second current path electrically connecting the voltage applicator and the discharge electrode.2. The electrostatic atomizing device according to claim 1 , whereinthe limiting resistor is disposed on the first current path, anda length of a wire between the counter electrode and the limiting resistor on the first current path is set to 30 mm or less.3. The ...

Подробнее
Номер записи: 99
28-01-2021 дата публикации

ORGANIC SILICA THIN FILM, METHOD FOR PRODUCING THE SAME, LASER DESORPTION/IONIZATION MASS SPECTROMETRIC SUBSTRATE USING THE SAME, AND LASER DESORPTION/IONIZATION MASS SPECTROMETRIC METHOD

Номер: US20210028000A1
Автор: GOTO Yasutomo, INAGAKI Shinji, MIZOSHITA Norihiro, SASAKI Yuri
Принадлежит: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO

An organic silica thin film including: organic silica having a light absorbable organic group in a skeleton, wherein the organic group has a local maximum absorption wavelength in a wavelength range of 200 to 1200 nm, a content ratio of silicon and the organic group which constitute the organic silica is in a range of 0.05 to 0.50 based on a ratio of a mass of the silicon to a mass of the organic group ([mass of the silicon]/[mass of the organic group]), the thin film has a textured structure, and an axis direction of the textured structure is a direction substantially perpendicular to a surface opposite to a surface of the organic silica thin film having the textured structure formed therein. 1. An organic silica thin film comprising:organic silica having a light absorbable organic group in a skeleton, whereinthe organic group has a local maximum absorption wavelength in a wavelength range of 200 to 1200 nm,a content ratio of silicon and the organic group which constitute the organic silica is in a range of 0.05 to 0.50 based on a ratio of a mass of the silicon to a mass of the organic group ([mass of the silicon]/[mass of the organic group]),the thin film has a textured structure, andan axis direction of the textured structure is a direction substantially perpendicular to a surface opposite of the organic silica thin film to a surface thereof having the textured structure formed therein.2. The organic silica thin film according to claim 1 , whereinthe organic group has a local maximum absorption wavelength in a wavelength range of 200 to 600 nm.3. The organic silica thin film according to claim 1 , whereinthe organic silica thin film is a porous film having a textured structure in which dent parts are formed of column-shaped pores or a thin film having a textured structure formed of a pillar array in which bump parts are formed of column-shaped bodies and the column-shaped bodies are arranged.4. A method for producing an organic silica thin film claim 1 , ...

Подробнее
Номер записи: 100