1,3-diazaphenothiazines and method
Реферат: The invention comprises compounds of the general formula <FORM:1014881/C2/1> wherein Y is a substituted amino group (i.e. alkylamino, dialkylamino, dialkylaminoalkylamino, 1-pyrrolidinyl, 1-piperidyl, 4-morpholinyl, or 4-alkyl-1-piperazinyl), Z is a halogen atom, or an amino, substituted amino, hydroxy or mercapto group; R1 and R2 is a hydrogen or halogen atom or an alkyl or alkoxy group (where "alkyl" and "alkoxy" have from 1 to 4 carbon atoms) and a process for the preparation of compounds of the above general formula where Y is a hydrogen atom or a hydroxy, amino or substituted amino, and R1, R2 and Z are as defined above by ring closure in dilute acid solution of a compound of the general formula <FORM:1014881/C2/2> where X is an amino or substituted'amino group. Pharmaceutical compositions contain as an active ingredient one of the following 1,3-diazaphenothiazines:- amino - 8 - chloro - 4 -11 - piperidyl-; 2,4 - diamino - 8 - chloro -; 2,4 - diamino - 7,8 - dimethyl -; 8 -chloro - 2 - dimethylamino - 4 - hydroxy-; and 4 - amino - 8 - chloro - 2 - dimethylamino -. The compositions may be in the form of tablets, capsules cachets, ampoules, or suppositories or as powders, granules, solutions, suspensions, in a non-aqueous or emulsified liquid or as an ointment. They have anti-bacterial and tranquillizing activity.
Pyrimidine compounds, methods for their preparing (variants), intermediate substances (variants) and methods for their preparing (variants), method for preparing triazolopyrimidine compounds
Номер патента: RU2295526C2. Автор: Ульф ЛАРССОН,Маттиас МАГНУССОН,Тибор МУСИЛЬ,Андреас ПАЛЬМГРЕН. Владелец: Астразенека Аб. Дата публикации: 2007-03-20.