Procedure for the synthesis of replaced flavanoids. (Machine-translation by Google Translate, not legally binding)
Реферат: Procedure for the synthesis of substituted flavanoids, of formula I **(See formula)** in which R1 and R2 signify OH, alkoxy with a total of 11 carbon atoms (optionally substituted tetrahydropyranyl- (2) -oxy, acyloxy with carbon atoms, NO2. NH2, amino with a total of 1 to 8 carbon atoms, acylamino with 2 to 6 carbon atoms, R3 means alkyl with 4 to 6 atoms of R4 means = O; H, OH; H, H or H, NH2, R5 means hydrogen or R1 and R2 and R5 also mean, together, methylenedioxyethylenedioxy or propylenedioxy, and of the acid addition salts and quaternary ammonium derivatives of these compounds, characterized in that a compound (optionally produced in situ) of the formula II is treated with cyclizing agents. **(See formula)** in which Ar means **(See formula)** X means -CR3 = CH- or -CHR3-CHX1-, X1 means OH, Hal or amino, Hal means chlorine, bromine or iodine, R1 to R5 have the meaning set out above and hydroxyphone groups may also exist in protected form, or a compound of formula III **(See formula)** in which Z means -CHR3-CHAr-, X2 means COOH, COHal, CH2OH or CH2Hal and Ar, R1, R2, R3, R5 and Hal have the meaning already stated, or because a compound of formula IV is treated with reducing agents **(See formula)** in which And means **(See formula)** R4, means O or H, OH, A stands for an anion of a strong acid, Ar and R1 to R5 have the meaning already stated and hydroxyphenolic groups may also exist in protected form, and optionally, in a compound of formula I, protected hydroxy and/or amino groups are released, by treatment with hydrolyzing or hydrogenating agents, or alkylated or added free hydroxy and/or amino groups, by treatment with alkylation or acylation agents or reducing nitro groups to amino groups, or convert a keto group at position 4, by consecutive oxidation and reduction, to an amino group, or converting a carboxylic acid or carboxylic acid alkyl ester group, by treatment with aminating agents, to a carbonamido group, and/or eventually converting the compounds of formula 1, by rubbing with acids or with alkylating agents, respectively, into their acid addition salts or their quaternary ammonium compounds, respectively, physiologically compatible. (Machine-translation by Google Translate, not legally binding)
Process for the solid phase synthesis of aldehydesketones oximes amines and hydroxamic acid compoun ds
Номер патента: OA11063A. Автор: Joseph M Salvino,Richard F Labaudiniere,George C Morton,Helen J Mason. Владелец: Rhone Poulenc Rorer Pharma. Дата публикации: 2002-03-12.