NEW DERIVATIVES OF 1H, 3H PIRROLO [1,2-C] TIAZOLO, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
Номер патента: ES2016375B3
Опубликовано: 01-11-1990
Автор(ы): Claude James, Daniel Lave, Jean-Louis Fabre
Принадлежит: Rhone Poulenc Sante SA
Опубликовано: 01-11-1990
Автор(ы): Claude James, Daniel Lave, Jean-Louis Fabre
Принадлежит: Rhone Poulenc Sante SA
Реферат: A compound of the general formula I: <IMAGE> (I) in which Ar is a pyridyl, quinolinyl, isoquinolinyl, naphthyridinyl, pyrimidyl, quinazolinyl, thiazolyl, benzothiazolyl, imidazolyl, benzimidazolyl, oxazolyl, benzoxazolyl, thienyl, benzothienyl or naphthyl group; optionally substituted with one or more halogen or alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, alkylsulphinyl, alkylsulphonyl, sulphamido, alkylsulphamido, dialkylsulphamido, alkylcarbonyl, benzoyl, alkyloxycarbonyl, carboxy, phenoxycarbonyl, alkylcabonyloxy, benzoyloxy, alkylcarbonylamino, benzamido, phenyl, benzyl, phenoxy or phenylthio group, provided that (i) when Ar is a pyridyl group, the pyridyl group must be substituted, (ii) an alkyl moiety contains 1 to 4 straight- or branched chain carbon atoms; (iii) a phenyl moiety may be unsubstituted or substituted with one or more halogen or alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, phenyl or benzyl group in separate enantiomeric form or mixtures thereof, or a pharmaceutically acceptable salt thereof is useful in the treatment of all pathological conditions in which PAF-acether may be implicated directly or indirectly.
Derivatives of 1h, 3h-pyrrolo [1,2-c] thiazole, their preparation and pharmaceutical compositions containing them
Номер патента: CA1294967C. Автор: Claude James,Jean-Louis Fabre,Daniel Lave. Владелец: Rhone Poulenc Sante SA. Дата публикации: 1992-01-28.